Richard M Weinshilboum, MD

  • 28270 Citations
  • 85 Scopus h-Index
1968 …2020

Research output per year

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Research Output

1998

Human histamine N-methyltransferase pharmacogenetics: Common genetic polymorphisms that alter activity

Preuss, C. V., Wood, T. C., Szumlanski, C. L., Raftogianis, R. B., Otterness, D. M., Girard, B., Scott, M. C. & Weinshilboum, R. M., Apr 1998, In : Molecular pharmacology. 53, 4, p. 708-717 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

Human hydroxysteroid sulfotransferase SULT2B1: Two enzymes encoded by a single chromosome 19 gene

Her, C., Wood, T. C., Eichler, E. E., Mohrenweiser, H. W., Ramagli, L. S., Siciliano, M. J. & Weinshilboum, R. M., Nov 1 1998, In : Genomics. 53, 3, p. 284-295 12 p.

Research output: Contribution to journalArticle

126 Scopus citations

Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity

Otterness, D. M., Szumlanski, C. L., Wood, T. C. & Weinshilboum, R. M., Mar 1 1998, In : Journal of Clinical Investigation. 101, 5, p. 1036-1044 9 p.

Research output: Contribution to journalArticle

Open Access
115 Scopus citations

Mouse nicotinamide N-methyltransferase gene: Molecular cloning, structural characterization, and chromosomal localization

Yan, L., Otterness, D. M., Kozak, C. A. & Weinshilboum, R. M., Jan 1 1998, In : DNA and Cell Biology. 17, 8, p. 659-667 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pharmacokinetics, dose adjustments, and 6-mercaptopurine/ methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency

Brandt Andersen, J., Szumlanski, C., Weinshilboum, R. M. & Schmiegelow, K., Mar 9 1998, In : Acta Paediatrica, International Journal of Paediatrics. 87, 1, p. 108-111 4 p.

Research output: Contribution to journalArticle

87 Scopus citations

Rabbit lung indolethylamine N-methyltransferase: cDNA and gene cloning and characterization

Thompson, M. A. & Weinshilboum, R. M., Dec 18 1998, In : Journal of Biological Chemistry. 273, 51, p. 34502-34510 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
1997

Human erythrocyte protein L-isoaspartyl methyltransferase: Heritability of basal activity and genetic polymorphism for thermal stability

David, C. L., Szumlanski, C. L., DeVry, C. G., Ok Park-Hah, J., Clarke, S., Weinshilboum, R. M. & Aswad, D. W., Oct 15 1997, In : Archives of Biochemistry and Biophysics. 346, 2, p. 277-286 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization

Her, C., Kaur, G. P., Athwal, R. S. & Weinshilboum, R. M., May 1 1997, In : Genomics. 41, 3, p. 467-470 4 p.

Research output: Contribution to journalArticle

96 Scopus citations

Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms

Otterness, D., Szumlanski, C., Lennard, L., Klemetsdal, B., Aarbakke, J., Park-Hah, J. O., Iven, H., Schmiegelow, K., Branum, E., O'Brien, J. & Weinshilboum, R., Jul 1 1997, In : Clinical pharmacology and therapeutics. 62, 1, p. 60-73 14 p.

Research output: Contribution to journalArticle

347 Scopus citations

Mouse liver nicotinamide N-methyltransferase: CDNA cloning expression, and nucleotide sequence polymorphisms

Yan, L., Otterness, D. M., Craddock, T. L. & Weinshilboum, R. M., Nov 15 1997, In : Biochemical Pharmacology. 54, 10, p. 1139-1149 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Olsalazine and 6-mercaptopurine-related bone marrow suppression: A possible drug-drug interaction

Lewis, L. D., Benin, A., Szumlanski, C. L., Otterness, D. M., Lennard, L., Weinshilboum, R. M. & Nierenberg, D. W., Oct 1 1997, In : Clinical pharmacology and therapeutics. 62, 4, p. 464-475 12 p.

Research output: Contribution to journalArticle

148 Scopus citations

Phenol sulfotransferase (PST) molecular pharmacogenetics

Raftogianis, R., Wood, T., Her, C., Van Loon, J. & Weinshilboum, R., Dec 1 1997, In : Clinical pharmacology and therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

Phenol sulfotransferase pharmacogenetics in humans: Association of common SULT1A1 alleles with TS PST phenotype

Raftogianis, R. B., Wood, T. C., Otterness, D. M., Van Loon, J. A. & Weinshilboum, R. M., Oct 9 1997, In : Biochemical and Biophysical Research Communications. 239, 1, p. 298-304 7 p.

Research output: Contribution to journalArticle

252 Scopus citations

Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.

Weinshilboum, R. M., Otterness, D. M., Aksoy, I. A., Wood, T. C., Her, C. & Raftogianis, R. B., Jan 1997, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 11, 1, p. 3-14 12 p.

Research output: Contribution to journalArticle

Sulfotransferase molecular biology: cDNAs and genes

Weinshilboum, R. M., Otterness, D. M., Aksoy, I. A., Wood, T. C., Her, C. & Raftogianis, R. B., Jan 1997, In : FASEB Journal. 11, 1, p. 3-14 12 p.

Research output: Contribution to journalReview article

376 Scopus citations

Thiopurine methyltransferase (TPMT) pharmacogenetics: Polymorphism characterization

Otterness, D., Szumlanski, C., Wood, T., Lennard, L., Klemetsdal, B., Aarbakke, J., Park-Hah, J., Iven, H., Branum, E., O'Brien, J. & Weinshilboum, R., Dec 1 1997, In : Clinical pharmacology and therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

1996
1 Scopus citations

Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders

Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y. M., Szumlanski, C. L. & Weinshilboum, R. M., Jul 19 1996, In : Pharmacogenetics. 6, 3, p. 243-250 8 p.

Research output: Contribution to journalArticle

1443 Scopus citations

Human dehydroepiandrosterone sulfotransferase pharmacogenetics: Quantitative Western analysis and gene sequence polymorphisms

Wood, T. C., Her, C., Aksoy, I., Otterness, D. M. & Weinshilboum, R. M., Dec 1 1996, In : Journal of Steroid Biochemistry and Molecular Biology. 59, 5-6, p. 467-478 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Human histamine n-methyltransferase gene: structural characterization and chromosomal localization

Raftogianis, B. B., Aksoy, S. & Weinshilboum, R. M., Jan 1 1996, In : Journal of Investigative Medicine. 44, 3, p. 253a

Research output: Contribution to journalArticle

Human histamine N-methyltransferase gene: Structural characterization and chromosomal localization

Aksoy, S., Raftogianis, R. & Weinshilboum, R., Feb 15 1996, In : Biochemical and Biophysical Research Communications. 219, 2, p. 548-554 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase Immunochemical characterization of individual variation

Her, C., Szumlanski, C., Aksoy, I. A. & Weinshilboum, R. M., Dec 1 1996, In : Drug Metabolism and Disposition. 24, 12, p. 1328-1335 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Human phenol sulfotransferase pharmacogenetics: STP1 * gene cloning and structural characterization

Raftogianis, R. B., Her, C. & Weinshilboum, R. M., Jan 1 1996, In : Pharmacogenetics. 6, 6, p. 473-487 15 p.

Research output: Contribution to journalArticle

44 Scopus citations

Human phenol sulfotransferase STP2 gene: Molecular cloning, structural characterization, and chromosomal localization

Her, C., Raftogianis, R. & Weinshilboum, R. M., May 1 1996, In : Genomics. 33, 3, p. 409-420 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Human thiopurine methyltransferase pharmacogenetics: Identification of a novel variant allele

Otterness, P. M., Szumlanski, C. L. & Weinshilboum, R. M., Jan 1 1996, In : Journal of Investigative Medicine. 44, 3, p. 248a

Research output: Contribution to journalArticle

7 Scopus citations

Long PCR: Selective suppression by restriction endonuclease digestion

Her, C. & Weinshilboum, R., Nov 1996, In : BioTechniques. 21, 5, p. 764-766 3 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Mouse liver nicotinamide N-methyltransferase pharmacogenetics: Biochemical properties and variation in activity among inbred strains

Scheller, T., Orgacka, H., Szumlanski, C. L. & Weinshilboum, R. M., Apr 2 1996, In : Pharmacogenetics. 6, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Thiopurine methyltransferase pharmacogenetics: Human gene cloning and characterization of a common polymorphism

Szumlanski, C., Otterness, D., Her, C., Lee, D., Brandriff, B., Kelsell, D., Spurr, N., Lennard, L., Wieben, E. & Weinshilboum, R., Jan 1 1996, In : DNA and Cell Biology. 15, 1, p. 17-30 14 p.

Research output: Contribution to journalArticle

278 Scopus citations
1995

A message from the Finance Committee chairperson

Weinshilboum, R. M., Oct 1995, In : Clinical pharmacology and therapeutics. 58, 4, 1 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone sulfotransferase gene (STD): Localization to human chromosome band 19q13.3

Otterness, D. M., Mohrenweiser, H. W., Brandriff, B. F. & Weinshilboum, R. M., Jan 1 1995, In : Cytogenetics and Cell Genetics. 70, 1-2, p. 45-47 3 p.

Research output: Contribution to journalArticle

24 Scopus citations

Human Dehydroepiandrosterone Sulfotransferase Gene: Molecular Cloning and Structural Characterization

Otterness, D. M., Her, C., Aksoy, S., Kimura, S., Wieben, E. D. & Weinshilboum, R. M., Apr 1995, In : DNA and Cell Biology. 14, 4, p. 331-341 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Human estrogen sulfotransferase gene (STE): Cloning, structure, and chromosomal localization

Her, C., Aksoy, I. A., Kimura, S., Brandriff, B. F., Wasmuth, J. J. & Weinshilboum, R. M., Sep 1 1995, In : Genomics. 29, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Human nicotinamide N-methyltransferase gene: Molecular cloning, structural characterization and chromosomal localization

Aksoy, S., Brandriff, B. F., Ward, A., Little, P. F. R. & Weinshilboum, R. M., Oct 1995, In : Genomics. 29, 3, p. 555-561 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
40 Scopus citations

Rapid restriction mapping by use of long PCR

Her, C. & Weinshilboum, R. M., Jan 1 1995, In : BioTechniques. 19, 4, p. 530-532 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Segregation analysis of human red blood cell thiopurine methyltransferase activity

Vuchetich, J. P., Weinshilboum, R. M. & Price, R. A., 1995, In : Genetic epidemiology. 12, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
202 Scopus citations

Thiopurine methyltransferase pharmacogenetics: Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1

Lee, D., Szumlanski, C., Houtman, J., Honchel, R., Rojas, K., Overhauser, J., Wieben, E. D. & Weinshilboum, R. M., Jan 1 1995, In : Drug Metabolism and Disposition. 23, 3, p. 398-405 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Toxicity and metabolism in mice of 2,6-dithiopurine, a potential chemopreventive agent

Qing, W. G., Powell, K. L., Stoica, G., Szumlanski, C. L., Weinshilboum, R. M. & Macleod, M. C., Jan 1 1995, In : Drug Metabolism and Disposition. 23, 8, p. 854-860 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
1994

Human dehydroepiandrosterone sulfotransferase: molecular cloning of cDNA and genomic DNA

Otterness, D. M. & Weinshilboum, R., Jun 1994, In : Chemico-Biological Interactions. 92, 1-3, p. 145-159 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Human histamine N-methyltransferase pharmacogenetics: Cloning and expression of kidney cDNA

Girard, B., Otterness, D. M., Wood, T. C., Honchel, R., Wieben, E. D. & Weinshilboum, R. M., Mar 1 1994, In : Molecular pharmacology. 45, 3, p. 461-468 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Human Liver Estrogen Sulfotransferase: Identification by cDNA Cloning and Expression

Aksoy, I. A., Wood, T. C. & Weinshilboum, R., May 15 1994, In : Biochemical and Biophysical Research Communications. 200, 3, p. 1621-1629 9 p.

Research output: Contribution to journalArticle

131 Scopus citations

Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization

Aksoy, S., Szumlanski, C. L. & Weinshilboum, R. M., Jan 1 1994, In : Journal of Biological Chemistry. 269, 20, p. 14835-14840 6 p.

Research output: Contribution to journalArticle

173 Scopus citations

Human liver thermolabile phenol sulfotransferase: Cdna cloning, expression and characterization

Wood, T. C., Aksoy, I. A., Aksoy, S. & Weinshilboum, R. M., Feb 14 1994, In : Biochemical and Biophysical Research Communications. 198, 3, p. 1119-1127 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

Purine substrates for human thiopurine methyltransferase

Deininger, M., Szumlanski, C. L., Otterness, D. M., Loon, J. V., Ferber, W. & Weinshilboum, R. M., Nov 29 1994, In : Biochemical Pharmacology. 48, 11, p. 2135-2138 4 p.

Research output: Contribution to journalArticle

55 Scopus citations

Sulfation pharmacogenetics in humans

Weinshilboum, R. & Aksoy, I., Jun 1994, In : Chemico-Biological Interactions. 92, 1-3, p. 233-246 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2

Aksoy, I. A., Callen, D. F., Apostolou, S., Her, C. & Weinshilboum, R. M., Sep 1 1994, In : Genomics. 23, 1, p. 275-277 3 p.

Research output: Contribution to journalArticle

27 Scopus citations

The ubiquitous nature of the progesterone receptor binding factor‐1 (RBF‐1) in avian tissues

Landers, J. P., Subramaniam, M., Gosse, B., Weinshilboum, R., Madden, B. J. & Spelsberg, T. C., Jun 1994, In : Journal of cellular biochemistry. 55, 2, p. 241-251 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
1993

Catechol o-methyltransferase pharmacogenetics: Photoaffinity labelling and western blot analysis of human liver samples

Aksoy, S., Klener, J. & Weinshilboum, R. M., Apr 1993, In : Pharmacogenetics. 3, 2, p. 116-122 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Cholesterol sulfation in human liver: Catalysis by dehydroepiandrosterone sulfotransferase

Aksoy, I. A., Otterness, D. M. & Weinshilboum, R. M., Jan 1 1993, In : Drug Metabolism and Disposition. 21, 2, p. 268-276 9 p.

Research output: Contribution to journalArticle

30 Scopus citations