Richard M Weinshilboum, MD

  • 28270 Citations
  • 85 Scopus h-Index
1968 …2020

Research output per year

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Research Output

2008

Gemcitabine pharmacogenomics: Deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics

Kocabas, N. A., Aksoy, P., Pelleymounter, L. L., Moon, I., Ryu, J. S., Gilbert, J. A., Salavaggione, O. E., Eckloff, B. W., Wieben, E. D., Yee, V., Weinshilboum, R. M. & Ames, M. M., Sep 2008, In : Drug Metabolism and Disposition. 36, 9, p. 1951-1959 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Glutathione S-transferase P1: Gene sequence variation and functional genomic studies

Moyer, A. M., Salavaggione, O. E., Wu, T. Y., Moon, I., Eckloff, B. W., Hildebrandt, M. A. T., Schaid, D. J., Wieben, E. D. & Weinshilboum, R. M., Jun 15 2008, In : Cancer research. 68, 12, p. 4791-4801 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: Common gene sequence variation and functional characterization

Li, F., Feng, Q., Lee, C., Wang, S., Pelleymounter, L. L., Moon, I., Eckloff, B. W., Wieben, E. D., Schaid, D. J., Yee, V. & Weinshilboum, R. M., Jul 1 2008, In : Molecular Genetics and Metabolism. 94, 3, p. 326-335 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Human phenylethanolamine N-methyltransferase genetic polymorphisms and exercise-induced epinephrine release

Ji, Y., Snyder, E. M., Fridley, B. L., Salavaggione, O. E., Moon, I., Batzler, A., Yee, V. C., Schaid, D. J., Joyner, M. J., Johnson, B. D. & Weinshilboum, R. M., May 1 2008, In : Physiological Genomics. 33, 3, p. 323-332 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
52 Scopus citations

Metabolomics: A global biochemical approach to drug response and disease

Kaddurah-Daouk, R., Kristal, B. S. & Weinshilboum, R. M., Jun 2 2008, In : Annual Review of Pharmacology and Toxicology. 48, p. 653-683 31 p.

Research output: Contribution to journalReview article

453 Scopus citations

Pharmacogenomics: Candidate gene identification, functional validation and mechanisms

Wang, L. & Weinshilboum, R. M., Oct 15 2008, In : Human molecular genetics. 17, R2, p. R174-R179

Research output: Contribution to journalArticle

49 Scopus citations

Pharmacogenomics of endocrine therapy in breast cancer

Weinshilboum, R., Dec 1 2008, Innovative Endocrinology of Cancer. Berstein, L. & Santen, R. (eds.). p. 220-231 12 p. (Advances in Experimental Medicine and Biology; vol. 630).

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Structural basis of substrate recognition in thiopurine S-methyltransferase

Peng, Y., Feng, Q., Wilk, D., Adjei, A. A., Salavaggione, O. E., Weinshilboum, R. M. & Yee, V. C., Jun 10 2008, In : Biochemistry. 47, 23, p. 6216-6225 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Thiopurine S-methyltransferase pharmacogenetics: Autophagy as a mechanism for variant allozyme degradation

Li, F., Wang, L., Burgess, R. J. & Weinshilboum, R. M., Dec 1 2008, In : Pharmacogenetics and genomics. 18, 12, p. 1083-1094 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
2007

A comprehensive examination of CYP19 variation and breast density

Olson, J. E., Ma, C. X., Pelleymounter, L. L., Schaid, D. J., Pankratz, V. S., Vierkant, R. A., Fredericksen, Z. S., Ingle, J. N., Wu, Y., Couch, F., Sellers, T. A., Weinshilboum, R. M. & Vachon, C. M., Mar 1 2007, In : Cancer Epidemiology Biomarkers and Prevention. 16, 3, p. 623-625 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches

Olson, J. E., Ingle, J. N., Ma, C. X., Pelleymounter, L. L., Schaid, D. J., Pankratz, V. S., Vierkant, R. A., Fredericksen, Z. S., Wu, Y., Couch, F. J., Vachon, C. M., Sellers, T. A. & Weinshilboum, R. M., Apr 1 2007, In : Breast Cancer Research and Treatment. 102, 2, p. 237-247 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Genetic diversity and function in the human cytosolic sulfotransferases

Hildebrandt, M. A. T., Carrington, D. P., Thomae, B. A., Eckloff, B. W., Schaid, D. J., Yee, V. C., Weinshilboum, R. M. & Wieben, E. D., Apr 1 2007, In : Pharmacogenomics Journal. 7, 2, p. 133-143 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Genetic nondiscrimination legislation: A critical prerequisite for pharmacogenomics data sharing

Altman, R. B., Benowitz, N., Gurwitz, D., Lunshol, J., Relling, M., Lamba, J., Wieben, E., Mooney, S., Giacomini, K., Weiss, S., Johnson, J. A., McLeod, H., Flockhart, D., Weinshilboum, R., Shuldiner, A. R., Roden, D., Kraus, R. M. & Ratain, M., May 1 2007, In : Pharmacogenomics. 8, 5, 1 p.

Research output: Contribution to journalComment/debate

8 Scopus citations

Glutathione S-transferase T1 and M1: Gene sequence variation and functional genomics

Moyer, A. M., Salavaggione, O. E., Hebbring, S. J., Moon, I., Hildebrandt, M. A. T., Eckloff, B. W., Schaid, D. J., Wieben, E. D. & Weinshilboum, R. M., Dec 1 2007, In : Clinical Cancer Research. 13, 23, p. 7207-7216 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Human 3β-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics

Wang, L., Salavaggione, E., Pelleymounter, L., Eckloff, B., Wieben, E. & Weinshilboum, R., Oct 1 2007, In : Journal of Steroid Biochemistry and Molecular Biology. 107, 1-2, p. 88-99 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: Gene sequence variation and functional genomics

Ji, Y., Moon, I., Zlatkovic, J., Salavaggione, O. E., Thomae, B. A., Eckloff, B. W., Wieben, E. D., Schaid, D. J. & Weinshilboum, R. M., Aug 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 322, 2, p. 529-540 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Human SULT1A1 gene: Copy number differences and functional implications

Hebbring, S. J., Adjei, A. A., Baer, J. L., Jenkins, G. D., Zhang, J., Cunningham, J. M., Schaid, D. J., Weinshilboum, R. M. & Thibodeau, S. N., Mar 1 2007, In : Human molecular genetics. 16, 5, p. 463-470 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Pemetrexed and oxaliplatin for metastatic colorectal cancer: results of a phase I Mayo Cancer Center Research Consortium trial, MC0248

Alberts, S. R., Kim, G. P., Mahoney, M. R., Gornet, M. K., Rubin, J., Ames, M., Goetz, M. P., Weinshilboum, R. M., Nicol, S. J. & Goldberg, R. M., Jul 2007, In : Clinical colorectal cancer. 6, 8, p. 572-577 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

Goetz, M. P., Knox, S. K., Suman, V. J., Rae, J. M., Safgren, S. L., Ames, M. M., Visscher, D. W., Reynolds, C., Couch, F. J., Lingle, W. L., Weinshilboum, R. M., Fritcher, E. G. B., Nibbe, A. M., Desta, Z., Nguyen, A., Flockhart, D. A., Perez, E. A. & Ingle, J. N., Jan 1 2007, In : Breast Cancer Research and Treatment. 101, 1, p. 113-121 9 p.

Research output: Contribution to journalArticle

478 Scopus citations

The Pharmacogenetics Research Network: From SNP discovery to clinical drug response

Giacomini, K. M., Brett, C. M., Altman, R. B., Benowitz, N. L., Dolan, M. E., Flockhart, D. A., Johnson, J. A., Hayes, D. F., Klein, T., Krauss, R. M., Kroetz, D. L., McLeod, H. L., Nguyen, A. T., Ratain, M. J., Relling, M. V., Reus, V., Roden, D. M., Schaefer, C. A., Shuldiner, A. R., Skaar, T. & 6 others, Tantisira, K., Tyndale, R. F., Wang, L., Weinshilboum, R. M., Weiss, S. T. & Zineh, I., Mar 1 2007, In : Clinical pharmacology and therapeutics. 81, 3, p. 328-345 18 p.

Research output: Contribution to journalReview article

182 Scopus citations
2006

Erratum: Glutathione S-transferase omega 1 and omega 2 pharmacogenomics (Drug Metabolism and Disposition (2006) 34 (1237-1246))

Mukherjee, B., Salavaggione, O. E., Pelleymounter, L. L., Moon, I., Eckloff, B. W., Schaid, D. J., Wieben, E. D. & Weinshilboum, R. M., Aug 31 2006, In : Drug Metabolism and Disposition. 34, 9, 1 p.

Research output: Contribution to journalComment/debate

Gemcitabine pharmacogenomics: Cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomics

Gilbert, J. A., Salavaggione, O. E., Ji, Y., Pelleymounter, L. L., Eckloff, B. W., Wieben, E. D., Ames, M. M. & Weinshilboum, R. M., Mar 15 2006, In : Clinical Cancer Research. 12, 6, p. 1794-1803 10 p.

Research output: Contribution to journalArticle

124 Scopus citations

Glutathione S-transferase omega 1 and omega 2 pharmacogenomics

Mukherjee, B., Salavaggione, O. E., Pelleymounter, L. L., Moon, I., Eckloff, B. W., Schaid, D. J., Wieben, E. D. & Weinshilboum, R. M., Jun 27 2006, In : Drug Metabolism and Disposition. 34, 7, p. 1237-1246 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Human arsenic methyltransferase (AS3MT) pharmacogenetics: Gene resequencing and functional genomics studies

Wood, T. C., Salavagionne, O. E., Mukherjee, B., Wang, L., Klumpp, A. F., Thomae, B. A., Eckloff, B. W., Schaid, D. J., Wieben, E. D. & Weinshilboum, R. M., Mar 17 2006, In : Journal of Biological Chemistry. 281, 11, p. 7364-7373 10 p.

Research output: Contribution to journalArticle

109 Scopus citations

Human methylenetetrahydrofolate reductase pharmacogenomics: Gene resequencing and functional genomics

Martin, Y. N., Salavaggione, O. E., Eckloff, B. W., Wieben, E. D., Schaid, D. J. & Weinshilboum, R. M., Apr 2006, In : Pharmacogenetics and genomics. 16, 4, p. 265-277 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

Methylenetetrahydrofolate reductase haplotype tag single-nucleotide polymorphisms and risk of breast cancer

Martin, Y. N., Olson, J. E., Ingle, J. N., Vierkant, R. A., Fredericksen, Z. S., Pankratz, V. S., Wu, Y., Schaid, D. J., Sellers, T. A. & Weinshilboum, R. M., Nov 1 2006, In : Cancer Epidemiology Biomarkers and Prevention. 15, 11, p. 2322-2324 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pharmacogenetics and pharmacogenomics: Development, science, and translation

Weinshilboum, R. M. & Wang, L., Oct 31 2006, Annual Review of Genomics and Human Genetics. Chakravarti, A. & Green, E. (eds.). p. 223-245 23 p. (Annual Review of Genomics and Human Genetics; vol. 7).

Research output: Chapter in Book/Report/Conference proceedingChapter

134 Scopus citations

Pharmacogenomics: Challenges and opportunities

Roden, D. M., Altman, R. B., Benowitz, N. L., Flockhart, D. A., Giacomini, K. M., Johnson, J. A., Krauss, R. M., McLeod, H. L., Ratain, M. J., Relling, M. V., Ring, H. Z., Shuldiner, A. R., Weinshilboum, R. M. & Weiss, S. T., May 15 2006, In : Annals of internal medicine. 145, 10, p. 749-757 9 p.

Research output: Contribution to journalReview article

189 Scopus citations

Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.

Weinshilboum, R. M., Jan 1 2006, In : Cellular and molecular neurobiology. 26, 4-6, p. 539-561 23 p.

Research output: Contribution to journalReview article

47 Scopus citations

Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: A review

Yang, P., Ebbert, J. O., Sun, Z. & Weinshilboum, R. M., Apr 10 2006, In : Journal of Clinical Oncology. 24, 11, p. 1761-1769 9 p.

Research output: Contribution to journalReview article

94 Scopus citations

Thiopurine S-methyltransferase pharmacogenetics: Insights, challenges and future directions

Wang, L. & Weinshilboum, R., Mar 13 2006, In : Oncogene. 25, 11, p. 1629-1638 10 p.

Research output: Contribution to journalReview article

161 Scopus citations
2005

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

Jin, Y., Desta, Z., Stearns, V., Ward, B., Ho, H., Lee, K. H., Skaar, T., Storniolo, A. M., Li, L., Araba, A., Blanchard, R., Nguyen, A., Ullmer, L., Hayden, J., Lemler, S., Weinshilboum, R. M., Rae, J. M., Hayes, D. F. & Flockhart, D. A., Jan 5 2005, In : Journal of the National Cancer Institute. 97, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

781 Scopus citations

Human aromatase: Gene resequencing and functional genomics

Ma, C. X., Adjei, A. A., Salavaggione, O. E., Coronel, J., Pelleymounter, L., Wang, L., Eckloff, B. W., Schaid, D., Wieben, E. D., Adjei, A. A. & Weinshilboum, R. M., Dec 1 2005, In : Cancer research. 65, 23, p. 11071-11082 12 p.

Research output: Contribution to journalArticle

167 Scopus citations

Human phenylethanolamine N-methyltransferase pharmacogenomics: Gene re-sequencing and functional genomics

Ji, Y., Salavaggione, O. E., Wang, L., Adjei, A. A., Eckloff, B., Wieben, E. D. & Weinshilboum, R. M., Dec 1 2005, In : Journal of neurochemistry. 95, 6, p. 1766-1776 11 p.

Research output: Contribution to journalArticle

34 Scopus citations
78 Scopus citations

Thiopurine S-methyltransferase pharmacogenetics: Variant allele functional and comparative genomics

Salavaggione, O. E., Wang, L., Wiepert, M., Yee, V. C. & Weinshilboum, R. M., Nov 2005, In : Pharmacogenetics and genomics. 15, 11, p. 801-815 15 p.

Research output: Contribution to journalArticle

109 Scopus citations
2004

Aggresome formation and pharmacogenetics: Sulfotransferase 1A3 as a model system

Wang, L., Yee, V. C. & Weinshilboum, R. M., Dec 10 2004, In : Biochemical and Biophysical Research Communications. 325, 2, p. 426-433 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily

Blanchard, R. L., Freimuth, R. R., Buck, J., Weinshilboum, R. M. & Coughtrie, M. W. H., Mar 1 2004, In : Pharmacogenetics. 14, 3, p. 199-211 13 p.

Research output: Contribution to journalArticle

228 Scopus citations

Cat Red Blood Cell Thiopurine S-Methyltransferase: Companion Animal Pharmacogenetics

Salavaggione, O. E., Yang, C., Kidd, L. B., Thomae, B. A., Pankratz, V. S., Trepanier, L. A. & Weinshilboum, R. M., Feb 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 2, p. 617-626 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Childhood leukaemia: A relationship between intracellular 6-mercaptopurine metabolites and neutropenia

Lennard, L., Rees, C. A., Lilleyman, J. S., Maddocks, J. L. & Weinshilboum, R. M., Dec 2004, In : British Journal of Clinical Pharmacology. 58, 7 SPEC. ISS., p. S867-S871

Research output: Contribution to journalComment/debate

12 Scopus citations

Childhood leukaemia: A relationship between intracellular 6-mercaptopurine metabolites and neutropenia

Lennard, L., Rees, C. A., Lilleyman, J. S., Maddocks, J. L. & Weinshilboum, R. M., Dec 2004, In : British Journal of Clinical Pharmacology. 58, 7 SPEC. ISS.

Research output: Contribution to journalArticle

Human catechol O-methyltransferase genetic variation: Gene resequencing and functional characterization of variant allozymes

Shield, A. J., Thomae, B. A., Eckloff, B. W., Wieben, E. D. & Weinshilboum, R. M., Mar 16 2004, In : Molecular Psychiatry. 9, 2, p. 151-160 10 p.

Research output: Contribution to journalArticle

129 Scopus citations

Human cytosolic sulfotransferase database mining: Identification of seven novel genes and pseudogenes

Freimuth, R. R., Wiepert, M., Chute, C. G., Wieben, E. D. & Weinshilboum, R. M., Mar 7 2004, In : Pharmacogenomics Journal. 4, 1, p. 54-65 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

Human SULT1A3 pharmacogenetics: Gene duplication and functional genomic studies

Hildebrandt, M. A. T., Salavaggione, O. E., Martin, Y. N., Flynn, H. C., Jalal, S., Wieben, E. D. & Weinshilboum, R. M., Sep 3 2004, In : Biochemical and Biophysical Research Communications. 321, 4, p. 870-878 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Pharmacogenetics: Inherited variation in amino acid sequence and altered protein quantity

Weinshilboum, R. & Wang, L., Apr 1 2004, In : Clinical pharmacology and therapeutics. 75, 4, p. 253-258 6 p.

Research output: Contribution to journalComment/debate

39 Scopus citations

Pharmacogenomics: Bench to bedside

Weinshilboum, R. & Wang, L., Sep 1 2004, In : Nature Reviews Drug Discovery. 3, 9, p. 739-748 10 p.

Research output: Contribution to journalReview article

217 Scopus citations

Primer on Medical Genomics Part XII: Pharmacogenomics - General Principles with Cancer as a Model

Goetz, M. P., Ames, M. M. & Weinshilboum, R. M., Mar 2004, In : Mayo Clinic proceedings. 79, 3, p. 376-384 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Thiopurine methyltransferase activity in red blood cells of dogs

Kidd, L. B., Salavaggione, O. E., Szumlanski, C. L., Miller, J. L., Weinshilboum, R. M. & Trepanier, L., Mar 1 2004, In : Journal of Veterinary Internal Medicine. 18, 2, p. 214-218 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
2003

Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: Functional genetic polymorphism

Thomae, B. A., Rifki, O. F., Theobald, M. A., Eckloff, B. W., Wieben, E. D. & Weinshilboum, R. M., Nov 1 2003, In : Journal of neurochemistry. 87, 4, p. 809-819 11 p.

Research output: Contribution to journalArticle

49 Scopus citations