Richard M Weinshilboum, MD

  • 28270 Citations
  • 85 Scopus h-Index
1968 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2-methoxyestradiol (2-ME2) sulfation: Possible metabolic pathway

Adjei, A. A., Wood, T. C. & Weinshilboum, R. M., Dec 1 2001, In : Clinical pharmacology and therapeutics. 69, 2, p. P75

Research output: Contribution to journalArticle

2 Scopus citations

3'-Phosphoadenosine-5'-phosphosulfate: Photoaffinity ligand for sulfotransferase enzymes

Otterness, D. M., Powers, S. P., Miller, L. J. & Weinshilboum, R. M., Jan 1 1991, In : Molecular pharmacology. 39, 1, p. 34-41 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2 Scopus citations

Accuracy of electronic medical record medication reconciliation in emergency department patients

Monte, A. A., Anderson, P., Hoppe, J. A., Weinshilboum, R. M., Vasiliou, V. & Heard, K. J., Jul 1 2015, In : Journal of Emergency Medicine. 49, 1, p. 78-84 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
89 Scopus citations

Acetaminophen-NAPQI hepatotoxicity: A cell line model system genome-wide association study

Moyer, A. M., Fridley, B. L., Jenkins, G. D., Batzler, A. J., Pelleymounter, L. L., Kalari, K. R., Ji, Y., Chai, Y., Nordgren, K. K. S. & Weinshilboum, R. M., 2011, In : Toxicological Sciences. 120, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

A comprehensive analysis of breast cancer microbiota and host gene expression

Thompson, K. J., Ingle, J. N., Tang, X., Chia, N., Jeraldo, P. R., Walther-Antonio, M. R., Kandimalla, K. K., Johnson, S., Yao, J. Z., Harrington, S. C., Suman, V. J., Wang, L., Weinshilboum, R. L., Boughey, J. C., Kocher, J. P., Nelson, H., Goetz, M. P. & Kalari, K. R., Nov 2017, In : PloS one. 12, 11, e0188873.

Research output: Contribution to journalArticle

18 Scopus citations

A comprehensive examination of CYP19 variation and breast density

Olson, J. E., Ma, C. X., Pelleymounter, L. L., Schaid, D. J., Pankratz, V. S., Vierkant, R. A., Fredericksen, Z. S., Ingle, J. N., Wu, Y., Couch, F., Sellers, T. A., Weinshilboum, R. M. & Vachon, C. M., Mar 1 2007, In : Cancer Epidemiology Biomarkers and Prevention. 16, 3, p. 623-625 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches

Olson, J. E., Ingle, J. N., Ma, C. X., Pelleymounter, L. L., Schaid, D. J., Pankratz, V. S., Vierkant, R. A., Fredericksen, Z. S., Wu, Y., Couch, F. J., Vachon, C. M., Sellers, T. A. & Weinshilboum, R. M., Apr 1 2007, In : Breast Cancer Research and Treatment. 102, 2, p. 237-247 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Acquired chromosomal anomalies in chronic lymphocytic leukemia patients compared with more than 50,000 quasi-normal participants

Laurie, C. C., Laurie, C. A., Smoley, S. A., Carlson, E. E., Flinn, I., Fridley, B. L., Greisman, H. A., Gribben, J. G., Jelinek, D. F., Nelson, S. C., Paietta, E., Schaid, D., Sun, Z., Tallman, M. S., Weinshilboum, R., Kay, N. E. & Shanafelt, T. D., Jan 2014, In : Cancer Genetics. 207, 1-2, p. 19-30 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes

The Mood Disorders Precision Medicine Consortium (MDPMC), Mar 1 2020, In : Journal of Affective Disorders. 264, p. 90-97 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Aggresome formation and pharmacogenetics: Sulfotransferase 1A3 as a model system

Wang, L., Yee, V. C. & Weinshilboum, R. M., Dec 10 2004, In : Biochemical and Biophysical Research Communications. 325, 2, p. 426-433 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Aging and aldosterone

Hegstad, R., Brown, R. D., Jiang, N. S., Kao, P., Weinshilboum, R. M., Strong, C. & Wisgerhof, M., Mar 1983, In : The American Journal of Medicine. 74, 3, p. 442-448 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

A letter to the members

Weinshilboum, R. M., 1987, In : Clinical Pharmacology and Therapeutics. 41, 4, p. 480 1 p.

Research output: Contribution to journalArticle

17 Scopus citations

Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A. C., Nelson, T. J., Hall-Flavin, D., Heard, K. J., Fredlender, C., Deng, Y., Elkins, J., Dani, K., Le, A. T., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

7 Scopus citations

A message from the Finance Committee chairperson

Weinshilboum, R. M., Oct 1995, In : Clinical pharmacology and therapeutics. 58, 4, 1 p.

Research output: Contribution to journalArticle

A Message from the President—Come to Orlando, March 25–28, 1987

Weinshilboum, R. M., 1987, In : Clinical Pharmacology and Therapeutics. 41, 1, p. 126 1 p.

Research output: Contribution to journalArticle

Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population

Boerwinkle, E., Turner, S. T., Weinshilboum, R., Johnson, M., Richelson, E. & Sing, C. F., Jan 1 1986, In : Genetic epidemiology. 3, 5, p. 365-378 14 p.

Research output: Contribution to journalArticle

67 Scopus citations

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno-Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. & 1 others, Weinshilboum, R. M., Jul 2019, In : Clinical pharmacology and therapeutics. 106, 1, p. 219-227 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Anastrozole has an association between degree of estrogen suppression and outcomes in early breast cancer and is a ligand for estrogen receptor

Ingle, J. N., Cairns, J., Suman, V. J., Shepherd, L. E., Fasching, P. A., Hoskin, T. L., Singh, R. J., Desta, Z., Kalari, K. R., Ellis, M. J., Goss, P. E., Chen, B. E., Volz, B., Barman, P., Carlson, E. E., Haddad, T., Goetz, M. P., Goodnature, B., Cuellar, M. E., Walters, M. A. & 4 others, Correia, C., Kaufmann, S. H., Weinshilboum, R. M. & Wang, L., Jun 15 2020, In : Clinical Cancer Research. 26, 12, p. 2986-2996 11 p.

Research output: Contribution to journalArticle

Open Access

A network-based phenotype mapping approach to identify genes that modulate drug response phenotypes

Cairns, J., Ung, C. Y., Da Rocha, E. L., Zhang, C., Correia, C., Weinshilboum, R. M., Wang, L. M. & Li, H., Nov 14 2016, In : Scientific Reports. 6, 37003.

Research output: Contribution to journalArticle

3 Scopus citations

Antiestrogen pathway (aromatase inhibitor)

Desta, Z., Nguyen, A., Flockhart, D., Skaar, T., Fletcher, R., Weinshilboum, R., Berlin, D. S., Klein, T. E. & Altman, R. B., Jul 1 2009, In : Pharmacogenetics and genomics. 19, 7, p. 554-555 2 p.

Research output: Contribution to journalShort survey

6 Scopus citations

Antihypertensive drugs that alter adrenergic function

Weinshilboum, R. M., Jan 1 1980, In : Mayo Clinic proceedings. 55, 6, p. 390-402 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

A phase I study of cytembena

Frytak, S., Moertel, C. G., Schutt, A. J., Ahmann, D. L., Donadio, J. V. & Weinshilboum, R. M., Mar 1976, In : Cancer. 37, 3, p. 1248-1255 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2

Vachon, C. M., Schaid, D. J., Ingle, J. N., Wickerham, D. L., Kubo, M., Mushiroda, T., Goetz, M. P., Carlson, E. E., Paik, S., Wolmark, N., Nakamura, Y., Wang, L., Weinshilboum, R. & Couch, F. J., Jan 1 2015, In : Breast Cancer Research and Treatment. 149, 2, p. 517-523 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily

Blanchard, R. L., Freimuth, R. R., Buck, J., Weinshilboum, R. M. & Coughtrie, M. W. H., Mar 1 2004, In : Pharmacogenetics. 14, 3, p. 199-211 13 p.

Research output: Contribution to journalArticle

228 Scopus citations

A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate-prednisone

Wang, L., Dehm, S. M., Hillman, D. W., Sicotte, H., Tan, W., Gormley, M., Bhargava, V., Jimenez, R., Xie, F., Yin, P., Qin, S., Quevedo, F., Costello, B. A., Pitot, H. C., Ho, T., Bryce, A. H., Ye, Z., Li, Y., Eiken, P., Vedell, P. T. & 16 others, Barman, P., McMenomy, B. P., Atwell, T. D., Carlson, R. E., Ellingson, M., Eckloff, B. W., Qin, R., Ou, F., Hart, S. N., Huang, H., Jen, J., Wieben, E. D., Kalari, K. R., Weinshilboum, R. M., Wang, L. & Kohli, M., Feb 1 2018, In : Annals of Oncology. 29, 2, p. 352-360 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Are patients willing to incur out-of-pocket costs for pharmacogenomic testing?

Bielinski, S. J., St. Sauver, J., Olson, J. E., Wieland, M. L., Vitek, C. R., Bell, E. J., Mc Gree, M. E., Jacobson, D. J., McCormick, J. B., Takahashi, P. Y., Black, J. L., Caraballo, P., Sharp, R. R., Beebe, T. J., Weinshilboum, R. M., Wang, L. M. & Roger, V. L., Oct 25 2016, (Accepted/In press) In : Pharmacogenomics Journal.

Research output: Contribution to journalArticle

8 Scopus citations

Aromatase inhibitor-associated bone fractures: A case-cohort GWAS and functional genomics

Liu, M., Goss, P. E., Ingle, J. N., Kubo, M., Furukawa, Y., Batzler, A., Jenkins, G. D., Carlson, E. E., Nakamura, Y., Schaid, D. J., Chapman, J. A. W., Shepherd, L. E., Ellis, M. J., Khosla, S., Wang, L. & Weinshilboum, R. M., Oct 1 2014, In : Molecular Endocrinology. 28, 10, p. 1740-1751 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Aromatase inhibitors, estrogens and musculoskeletal pain: Estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression

Liu, M., Wang, L., Bongartz, T., Hawse, J. R., Markovic, S. N., Schaid, D. J., Mushiroda, T., Kubo, M., Nakamura, Y., Kamatani, N., Goss, P. E., Ingle, J. N. & Weinshilboum, R. M., Mar 9 2012, In : Breast Cancer Research. 14, 2, R41.

Research output: Contribution to journalArticle

46 Scopus citations

A sensitive enzymatic assay for dopamine- -hydroxylase.

Molinoff, P. B., Weinshilboum, R. & Axelrod, J., Sep 1 1971, In : Journal of Pharmacology and Experimental Therapeutics. 178, 3, p. 425-431 7 p.

Research output: Contribution to journalArticle

388 Scopus citations

Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen

Schroth, W., Goetz, M. P., Hamann, U., Fasching, P. A., Schmidt, M., Winter, S., Fritz, P., Simon, W., Suman, V. J., Ames, M. M., Safgren, S. L., Kuffel, M. J., Ulmer, H. U., Boländer, J., Strick, R., Beckmann, M. W., Koelbl, H., Weinshilboum, R. M., Ingle, J. N., Eichelbaum, M. & 2 others, Schwab, M. & Brauch, H., Oct 19 2009, In : JAMA - Journal of the American Medical Association. 302, 13, p. 1429-1436 8 p.

Research output: Contribution to journalArticle

421 Scopus citations

Association of the polygenic scores for personality traits and response to selective serotonin reuptake inhibitors in patients with major depressive disorder

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Mar 6 2018, In : Frontiers in Psychiatry. 9, MAR, 65.

Research output: Contribution to journalArticle

8 Scopus citations

Augmentation of physician assessments with multi-omics enhances predictability of drug response: A case study of major depressive disorder

Athreya, A., Iyer, R., Neavin, D., Wang, L. M., Weinshilboum, R. M., Kaddurah-Daouk, R., Rush, J., Frye, M. A. & Bobo, W. V., Aug 1 2018, In : IEEE Computational Intelligence Magazine. 13, 3, p. 20-31 12 p., 8416980.

Research output: Contribution to journalArticle

10 Scopus citations

Author Correction: Regulation of sister chromatid cohesion by nuclear PD-L1 (Cell Research, (2020), 30, 7, (590-601), 10.1038/s41422-020-0315-8)

Yu, J., Qin, B., Moyer, A. M., Nowsheen, S., Tu, X., Dong, H., Boughey, J. C., Goetz, M. P., Weinshilboum, R., Lou, Z. & Wang, L., 2020, (Accepted/In press) In : Cell Research.

Research output: Contribution to journalComment/debate

Open Access

Automated discovery of drug treatment patterns for endocrine therapy of breast cancer within an electronic medical record

Savova, G. K., Olson, J. E., Murphy, S. P., Cafourek, V. L., Couch, F. J., Goetz, M. P., Ingle, J. N., Suman, V. J., Chute, C. G. & Weinshilboum, R. M., Jun 2012, In : Journal of the American Medical Informatics Association. 19, E1, p. e83-e89

Research output: Contribution to journalArticle

19 Scopus citations

Balsalazide and azathioprine or 6-mercaptopurine: Evidence for a potentially serious drug interaction [3]

Lowry, P. W., Szumlanski, C. L., Weinshilboum, R. M. & Sandborn, W. J., 1999, In : Gastroenterology. 116, 6, p. 1505-1506 2 p.

Research output: Contribution to journalLetter

70 Scopus citations

Benefits of and Barriers to Pharmacogenomics-Guided Treatment for Major Depressive Disorder

Ahmed, A. T., Weinshilboum, R. M. & Frye, M. A., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

6 Scopus citations

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: Metabolomics-informed genomics

Liu, D., Ray, B., Neavin, D. R., Zhang, J., Athreya, A. P., Biernacka, J. M., Bobo, W. V., Hall-Flavin, D. K., Skime, M. K., Zhu, H., Jenkins, G. D., Batzler, A., Kalari, K. R., Boakye-Agyeman, F., Matson, W. R., Bhasin, S. S., Mushiroda, T., Nakamura, Y., Kubo, M., Iyer, R. K. & 4 others, Wang, L. M., Frye, M. A., Kaddurah-Daouk, R. & Weinshilboum, R. M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 56.

Research output: Contribution to journalArticle

15 Scopus citations

Betaine-homocysteine methyltransferase: Human liver genotype-phenotype correlation

Feng, Q., Kalari, K., Fridley, B. L., Jenkins, G., Ji, Y., Abo, R., Hebbring, S., Zhang, J., Nye, M. D., Leeder, J. S. & Weinshilboum, R. M., Feb 1 2011, In : Molecular genetics and metabolism. 102, 2, p. 126-133 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Biochemical genetics of cathecholamines in humans

Weinshilboum, R. M., Jan 1 1983, In : Mayo Clinic proceedings. 58, 5, p. 319-330 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Biochemical genetics of human erythrocyte (RBC) thiopurine methyltransferase (TPMT): Correlation of immunoreactive protein with enzyme activity

Woodson, L. C., Dunnette, J. H. & Weinshilboum, R. M., Jan 1 1981, In : Pharmacologist. 23, 3, p. No. 234

Research output: Contribution to journalArticle

1 Scopus citations

BRCA1/2 Mutations and bevacizumab in the neoadjuvant treatment of breast cancer: Response and prognosis results in patients with triple-negative breast cancer From the geparquinto study

Fasching, P. A., Loibl, S., Hu, C., Hart, S. N., Shimelis, H., Moore, R., Schem, C., Tesch, H., Untch, M., Hilfrich, J., Rezai, M., Gerber, B., Costa, S. D., Blohmer, J. U., Fehm, T., Huober, J., Liedtke, C., Weinshilboum, R. M., Wang, L., Ingle, J. N. & 7 others, Müller, V., Nekljudova, V., Weber, K. E., Rack, B., Rübner, M., Von Minckwitz, G. & Couch, F. J., Aug 1 2018, In : Journal of Clinical Oncology. 36, 22, p. 2281-2287 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms

Ji, Y., Olson, J., Zhang, J., Hildebrandt, M., Wang, L., Ingle, J., Fredericksen, Z., Sellers, T., Miller, W., Dixon, J. M., Brauch, H., Eichelbaum, M., Justenhoven, C., Hamann, U., Ko, Y., Brüning, T., Chang-Claude, J., Wang-Gohrke, S., Schaid, D. & Weinshilboum, R., Jul 15 2008, In : Cancer research. 68, 14, p. 5997-6005 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Calcium inhibition of rat liver catechol-O-methyltransferase

Weinshilboum, R. M. & Raymond, F. A., Mar 1 1976, In : Biochemical Pharmacology. 25, 5, p. 573-579 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

Qin, S., Ingle, J. N., Liu, M., Yu, J., Wickerham, D. L., Kubo, M., Weinshilboum, R. M. & Wang, L., Aug 18 2017, In : Breast Cancer Research. 19, 1, 95.

Research output: Contribution to journalArticle

11 Scopus citations

Cancer pharmacogenomics and pharmacoepidemiology: Setting a research agenda to accelerate translation

Freedman, A. N., Sansbury, L. B., Figg, W. D., Potosky, A. L., Weiss Smith, S. R., Khoury, M. J., Nelson, S. A., Weinshilboum, R. M., Ratain, M. J., McLeod, H. L., Epstein, R. S., Ginsburg, G. S., Schilsky, R. L., Liu, G., Flockhart, D. A., Ulrich, C. M., Davis, R. L., Lesko, L. J., Zineh, I., Randhawa, G. & 8 others, Ambrosone, C. B., Relling, M. V., Rothman, N., Xie, H., Spitz, M. R., Ballard-Barbash, R., Doroshow, J. H. & Minasian, L. M., Nov 2010, In : Journal of the National Cancer Institute. 102, 22, p. 1698-1705 8 p.

Research output: Contribution to journalComment/debate

38 Scopus citations

Canine red blood cell thiopurine S-methyltransferase: Companion animal pharmacogenetics

Salavaggione, O. E., Kidd, L., Prondzinski, J. L., Szumlanski, C. L., Pankratz, V. S., Wang, L., Trepanier, L. & Weinshilboum, R. M., Dec 1 2002, In : Pharmacogenetics. 12, 9, p. 713-724 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cardiovascular pharmacogenomics and individualized drug therapy

Pereira, N. L. & Weinshilboum, R. M., Oct 2009, In : Nature Reviews Cardiology. 6, 10, p. 632-638 7 p.

Research output: Contribution to journalArticle

37 Scopus citations