Richard M Weinshilboum, MD

  • 28270 Citations
  • 85 Scopus h-Index
1968 …2020

Research output per year

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Research Output

2012

Multivariate models to detect genomic signatures for a class of drugs: Application to thiopurines pharmacogenomics

Fridley, B. L., Jenkins, G. D., Batzler, A., Wang, L., Ji, Y., Li, F. & Weinshilboum, R. M., Apr 1 2012, In : Pharmacogenomics Journal. 12, 2, p. 105-110 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacogenomics

Wang, L. M. & Weinshilboum, R. M., Oct 31 2012, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Third Edition. Wolters Kluwer (UK) Ltd., p. 199-219 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pharmacogenomics and patient care: One size does not fit all

Giacomini, K. M., Yee, S. W., Ratain, M. J., Weinshilboum, R. M., Kamatani, N. & Nakamura, Y., Sep 26 2012, In : Science translational medicine. 4, 153, 153ps18.

Research output: Contribution to journalReview article

27 Scopus citations

PharmGKB summary: Very important pharmacogene information for GSTT1

Thorn, C. F., Ji, Y., Weinshilboum, R. M., Altman, R. B. & Klein, T. E., Aug 1 2012, In : Pharmacogenetics and genomics. 22, 8, p. 646-651 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Serine hydroxymethyltransferase 1 and 2: Gene sequence variation and functional genomic characterization

Hebbring, S. J., Chai, Y., Ji, Y., Abo, R. P., Jenkins, G. D., Fridley, B., Zhang, J., Eckloff, B. W., Wieben, E. D. & Weinshilboum, R. M., Mar 1 2012, In : Journal of neurochemistry. 120, 6, p. 881-890 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Using the gene ontology to scan multilevel gene sets for associations in genome wide association studies

Schaid, D. J., Sinnwell, J. P., Jenkins, G. D., McDonnell, S. K., Ingle, J. N., Kubo, M., Goss, P. E., Costantino, J. P., Wickerham, D. L. & Weinshilboum, R. M., Jan 1 2012, In : Genetic epidemiology. 36, 1, p. 3-16 14 p.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Acetaminophen-NAPQI hepatotoxicity: A cell line model system genome-wide association study

Moyer, A. M., Fridley, B. L., Jenkins, G. D., Batzler, A. J., Pelleymounter, L. L., Kalari, K. R., Ji, Y., Chai, Y., Nordgren, K. K. S. & Weinshilboum, R. M., 2011, In : Toxicological Sciences. 120, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Betaine-homocysteine methyltransferase: Human liver genotype-phenotype correlation

Feng, Q., Kalari, K., Fridley, B. L., Jenkins, G., Ji, Y., Abo, R., Hebbring, S., Zhang, J., Nye, M. D., Leeder, J. S. & Weinshilboum, R. M., Feb 1 2011, In : Molecular genetics and metabolism. 102, 2, p. 126-133 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

CYP2C19 variation and citalopram response

Mrazek, D. A., Biernacka, J. M., O'Kane, D. J., Black, J. L., Cunningham, J. M., Drews, M. S., Snyder, K. A., Stevens, S. R., Rush, A. J. & Weinshilboum, R. M., Jan 1 2011, In : Pharmacogenetics and genomics. 21, 1, p. 1-9 9 p.

Research output: Contribution to journalReview article

86 Scopus citations

Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: Results from the NSABP P1 and P2 clinical trials

Goetz, M. P., Schaid, D. J., Wickerham, D. L., Safgren, S., Mushiroda, T., Kubo, M., Batzler, A., Costantino, J. P., Vogel, V. G., Paik, S., Carlson, E. E., Flockhart, D. A., Wolmark, N., Nakamura, Y., Weinshilboum, R. M., Ingle, J. N. & Ames, M. M., Nov 1 2011, In : Clinical Cancer Research. 17, 21, p. 6944-6951 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Gene set analysis of purine and pyrimidine antimetabolites cancer therapies

Fridley, B. L., Batzler, A., Li, L., Li, F., Matimba, A., Jenkins, G. D., Ji, Y., Wang, L. & Weinshilboum, R. M., Nov 1 2011, In : Pharmacogenetics and genomics. 21, 11, p. 701-712 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Genomics and drug response

Wang, L., McLeod, H. L. & Weinshilboum, R. M., Mar 24 2011, In : New England Journal of Medicine. 364, 12, p. 1144-1153 10 p.

Research output: Contribution to journalReview article

429 Scopus citations

Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: Pharmacometabolomics-informed pharmacogenomics

Ji, Y., Hebbring, S., Zhu, H., Jenkins, G. D., Biernacka, J., Snyder, K., Drews, M., Fiehn, O., Zeng, Z., Schaid, D., Mrazek, D. A., Kaddurah-Daouk, R. & Weinshilboum, R. M., Jan 1 2011, In : Clinical pharmacology and therapeutics. 89, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

Methionine adenosyltransferase 2A/2B and methylation: Gene sequence variation and functional genomics

Nordgren, K. K. S., Peng, Y., Pelleymounter, L. L., Moon, I., Abo, R., Feng, Q., Eckloff, B., Yee, V. C., Wieben, E. & Weinshilboum, R. M., Nov 1 2011, In : Drug Metabolism and Disposition. 39, 11, p. 2135-2147 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mycophenolic acid response biomarkers: A cell line model system-based genome-wide screen

Wu, T. Y., Fridley, B. L., Jenkins, G. D., Batzler, A., Wang, L. & Weinshilboum, R. M., Aug 2011, In : International Immunopharmacology. 11, 8, p. 1057-1064 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen

Moyer, A. M., Suman, V. J., Weinshilboum, R. M., Avula, R., Black, J. L., Safgren, S. L., Kuffel, M. J., Ames, M. M., Ingle, J. N. & Goetz, M. P., Nov 1 2011, In : Pharmacogenomics. 12, 11, p. 1535-1543 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

The impact of pharmacogenomics on the management of cardiac disease

Pereira, N. L. & Weinshilboum, R. M., Oct 1 2011, In : Clinical pharmacology and therapeutics. 90, 4, p. 493-495 3 p.

Research output: Contribution to journalReview article

13 Scopus citations
2010

Cancer pharmacogenomics and pharmacoepidemiology: Setting a research agenda to accelerate translation

Freedman, A. N., Sansbury, L. B., Figg, W. D., Potosky, A. L., Weiss Smith, S. R., Khoury, M. J., Nelson, S. A., Weinshilboum, R. M., Ratain, M. J., McLeod, H. L., Epstein, R. S., Ginsburg, G. S., Schilsky, R. L., Liu, G., Flockhart, D. A., Ulrich, C. M., Davis, R. L., Lesko, L. J., Zineh, I., Randhawa, G. & 8 others, Ambrosone, C. B., Relling, M. V., Rothman, N., Xie, H., Spitz, M. R., Ballard-Barbash, R., Doroshow, J. H. & Minasian, L. M., Nov 2010, In : Journal of the National Cancer Institute. 102, 22, p. 1698-1705 8 p.

Research output: Contribution to journalComment/debate

38 Scopus citations

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system

Hartman, W. R., Pelleymounter, L. L., Moon, I., Kalari, K., Liu, M., Wu, T. Y., Escande, C., Nin, V., Chini, E. N. & Weinshilboum, R. M., Jul 1 2010, In : Leukemia and Lymphoma. 51, 7, p. 1315-1325 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Coprescription of tamoxifen and medications that inhibit CYP2D6

Sideras, K., Ingle, J. N., Ames, M. M., Loprinzi, C. L., Mrazek, D. P., Black, J. L., Weinshilboum, R. M., Hawse, J. R., Spelsberg, T. C. & Goetz, M. P., Jun 1 2010, In : Journal of Clinical Oncology. 28, 16, p. 2768-2776 9 p.

Research output: Contribution to journalReview article

100 Scopus citations

Copy number variation and cytidine analogue cytotoxicity: A genome-wide association approach

Kalari, K. R., Hebbring, S. J., Chai, H. S., Li, L., Kocher, J. P. A., Wang, L. & Weinshilboum, R. M., Jun 4 2010, In : BMC genomics. 11, 1, 357.

Research output: Contribution to journalArticle

19 Scopus citations

Ecto-5′-nucleotidase and thiopurine cellular circulation: Association with cytotoxicity

Li, F., Fridley, B. L., Matimba, A., Kalari, K. R., Pelleymounter, L., Moon, I., Ji, Y., Jenkins, G. D., Batzler, A., Wang, L. & Weinshilboum, R. M., Dec 2010, In : Drug Metabolism and Disposition. 38, 12, p. 2329-2338 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors

Wang, L., Ellsworth, K. A., Moon, I., Pelleymounter, L. L., Eckloff, B. W., Martin, Y. N., Fridley, B. L., Jenkins, G. D., Batzler, A., Suman, V. J., Ravi, S., Dixon, J. M., Miller, W. R., Wieben, E. D., Buzdar, A., Weinshilboum, R. M. & Ingle, J. N., Jan 1 2010, In : Cancer research. 70, 1, p. 319-328 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors

Ingle, J. N., Schaid, D. J., Goss, P. E., Liu, M., Mushiroda, T., Chapman, J. A. W., Kubo, M., Jenkins, G. D., Batzler, A., Shepherd, L., Pater, J., Wang, L., Ellis, M. J., Stearns, V., Rohrer, D. C., Goetz, M. P., Pritchard, K. I., Flockhart, D. A., Nakamura, Y. & Weinshilboum, R. M., Nov 1 2010, In : Journal of Clinical Oncology. 28, 31, p. 4674-4682 9 p.

Research output: Contribution to journalArticle

152 Scopus citations
34 Scopus citations
16 Scopus citations

Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: Gene sequence variation and functional genomics

Wu, T. Y., Peng, Y., Pelleymounter, L. L., Moon, I., Eckloff, B. W., Wieben, E. D., Yee, V. C. & Weinshilboum, R. M., Dec 1 2010, In : British Journal of Pharmacology. 161, 7, p. 1584-1598 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report

Erzurum, S., Rounds, S. I., Stevens, T., Aldred, M., Aliotta, J., Archer, S. L., Asosingh, K., Balaban, R., Bauer, N., Bhattacharya, J., Bogaard, H., Choudhary, G., Dorn, G. W., Dweik, R., Fagan, K., Fallon, M., Finkel, T., Geraci, M., Gladwin, M. T., Hassoun, P. M. & 23 others, Humbert, M., Kaminski, N., Kawut, S. M., Loscalzo, J., McDonald, D., McMurtry, I. F., Newman, J., Nicolls, M., Rabinovitch, M., Shizuru, J., Oka, M., Polgar, P., Rodman, D., Schumacker, P., Stenmark, K., Tuder, R., Voelkel, N., Sullivan, E., Weinshilboum, R., Yoder, M. C., Zhao, Y., Gail, D. & Moore, T. M., Dec 15 2010, In : American journal of respiratory and critical care medicine. 182, 12, p. 1554-1562 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Thiopurine pathway

Zaza, G., Cheok, M., Krynetskaia, N., Thorn, C., Stocco, G., Hebert, J. M., McLeod, H., Weinshilboum, R. M., Relling, M. V., Evans, W. E., Klein, T. E. & Altman, R. B., Sep 1 2010, In : Pharmacogenetics and genomics. 20, 9, p. 573-574 2 p.

Research output: Contribution to journalShort survey

53 Scopus citations

Thiopurine S-methyltransferase pharmacogenetics: Functional characterization of a novel rapidly degraded variant allozyme

Feng, Q., Vannaprasaht, S., Peng, Y., Angsuthum, S., Avihingsanon, Y., Yee, V. C., Tassaneeyakul, W. & Weinshilboum, R. M., Apr 1 2010, In : Biochemical Pharmacology. 79, 7, p. 1053-1061 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Thiopurine S-Methyltransferase Pharmacogenomics: Protein Misfolding, Aggregation, and Degradation

Li, F. & Weinshilboum, R. M., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 453-468 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer

Ingle, J. N., Buzdar, A. U., Schaid, D. J., Goetz, M. P., Batzler, A., Robson, M. E., Northfelt, D. W., Olson, J. E., Perez, E. A., Desta, Z., Weintraub, R. A., Williard, C. V., Flockhart, D. A. & Weinshilboum, R. M., Apr 15 2010, In : Cancer research. 70, 8, p. 3278-3286 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Very important pharmacogene summary: Thiopurine S-methyltransferase

Wang, L., Pelleymounter, L., Weinshilboum, R., Johnson, J. A., Hebert, J. M., Altman, R. B. & Klein, T. E., Jun 1 2010, In : Pharmacogenetics and genomics. 20, 6, p. 401-405 5 p.

Research output: Contribution to journalReview article

28 Scopus citations
2009

Antiestrogen pathway (aromatase inhibitor)

Desta, Z., Nguyen, A., Flockhart, D., Skaar, T., Fletcher, R., Weinshilboum, R., Berlin, D. S., Klein, T. E. & Altman, R. B., Jul 1 2009, In : Pharmacogenetics and genomics. 19, 7, p. 554-555 2 p.

Research output: Contribution to journalShort survey

6 Scopus citations

Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen

Schroth, W., Goetz, M. P., Hamann, U., Fasching, P. A., Schmidt, M., Winter, S., Fritz, P., Simon, W., Suman, V. J., Ames, M. M., Safgren, S. L., Kuffel, M. J., Ulmer, H. U., Boländer, J., Strick, R., Beckmann, M. W., Koelbl, H., Weinshilboum, R. M., Ingle, J. N., Eichelbaum, M. & 2 others, Schwab, M. & Brauch, H., Oct 19 2009, In : JAMA - Journal of the American Medical Association. 302, 13, p. 1429-1436 8 p.

Research output: Contribution to journalArticle

421 Scopus citations

Cardiovascular pharmacogenomics and individualized drug therapy

Pereira, N. L. & Weinshilboum, R. M., Oct 2009, In : Nature Reviews Cardiology. 6, 10, p. 632-638 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Catechol O-methyltransferase pharmacogenomics: Human liver genotype-phenotype correlation and proximal promoter studies

Zhang, J., Ji, Y., Moon, I., Pelleymounter, L. L., Ezequel Salavaggione, O., Wu, Y., Jenkins, G. D., Batzler, A. J., Schaid, D. J. & Weinshilboum, R. M., Aug 1 2009, In : Pharmacogenetics and genomics. 19, 8, p. 577-587 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cytosolic 5′-nucleotidase III (NT5C3): Gene sequence variation and functional genomics

Aksoy, P., Zhu, M. J., Kalari, K. R., Moon, I., Pelleymounter, L. L., Eckloff, B. W., Wieben, E. D., Yee, V. C., Weinshilboum, R. M. & Wang, L., Aug 1 2009, In : Pharmacogenetics and genomics. 19, 8, p. 567-576 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Endocrine therapy in 2009: Consideration of the tumor and the host

Goetz, M. P., Ames, M. M., Weinshilboum, R. M. & Ingle, J. N., Feb 1 2009, In : Oncology. 23, 2, p. 150-151+154

Research output: Contribution to journalReview article

Gemcitabine and arabinosylcytosin pharmacogenomics: Genome-wide association and drug response biomarkers

Li, L., Fridley, B. L., Kalari, K., Jenkins, G., Batzler, A., Weinshilboum, R. M. & Wang, L., Nov 9 2009, In : PloS one. 4, 11, e7765.

Research output: Contribution to journalArticle

62 Scopus citations

Human S-adenosylhomocysteine hydrolase: Common gene sequence variation and functional genomic characterization

Feng, Q., Keshtgarpour, M., Pelleymounter, L. L., Moon, I., Kalari, K. R., Eckloff, B. W., Wieben, E. D. & Weinshilboum, R. M., Sep 1 2009, In : Journal of neurochemistry. 110, 6, p. 1806-1817 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: Results from the NOPHO ALL-92 study

Schmiegelow, K., Al-Modhwahi, I., Andersen, M. K., Behrendtz, M., Forestier, E., Hasle, H., Heyman, M., Kristinsson, J., Nersting, J., Nygaard, R., Svendsen, A. L., Vettenranta, K. & Weinshilboum, R., Nov 19 2009, In : Blood. 113, 24, p. 6077-6084 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

Response: Could mutations in the hypoxanthine-guanine phosphoribosyl transferase gene induced by thiopurine therapy promote the development of second malignant neoplasms?

Schmiegelow, K., Al-Modhawi, I., Andersen, M. K., Berendtz, M., Forestier, E., Hasle, H., Heyman, M., Kristinsson, J., Nersting, J., Nygaard, R., Svendsen, A. L., Vettenranta, K. & Weinshilboum, R., Nov 18 2009, In : Blood. 113, 24, p. 6258-6259 2 p.

Research output: Contribution to journalLetter

SLC6A4 variation and citalopram response

Mrazek, D. A., Rush, A. J., Biernacka, J. M., O'Kane, D. J., Cunningham, J. M., Wieben, E. D., Schaid, D. J., Drews, M. S., Courson, V. L., Snyder, K. A., Black, J. L. & Weinshilboum, R. M., Apr 5 2009, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 150, 3, p. 341-351 11 p.

Research output: Contribution to journalArticle

127 Scopus citations

Sulfotransferase gene copy number variation: Pharmacogenetics and function

Hebbring, S. J., Moyer, A. M. & Weinshilboum, R. M., Mar 1 2009, In : Cytogenetic and Genome Research. 123, 1-4, p. 205-210 6 p.

Research output: Contribution to journalReview article

24 Scopus citations

Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: Results from the NOPHO ALL-92 study

Schmiegelow, K., Forestier, E., Kristinsson, J., Söderhäll, S., Vettenranta, K., Weinshilboum, R. & Wesenberg, F., Jan 1 2009, In : Leukemia. 23, 3, p. 557-564 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Very important pharmacogene summary: Sulfotransferase 1A1

Hildebrandt, M., Adjei, A., Weinshilboum, R., Johnson, J. A., Berlin, D. S., Klein, T. E. & Altman, R. B., Jun 1 2009, In : Pharmacogenetics and genomics. 19, 6, p. 404-406 3 p.

Research output: Contribution to journalReview article

13 Scopus citations
2008

Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms

Ji, Y., Olson, J., Zhang, J., Hildebrandt, M., Wang, L., Ingle, J., Fredericksen, Z., Sellers, T., Miller, W., Dixon, J. M., Brauch, H., Eichelbaum, M., Justenhoven, C., Hamann, U., Ko, Y., Brüning, T., Chang-Claude, J., Wang-Gohrke, S., Schaid, D. & Weinshilboum, R., Jul 15 2008, In : Cancer research. 68, 14, p. 5997-6005 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: Combining inherited and tumor gene markers for prediction of tamoxifen resistance

Goetz, M. P., Suman, V. J., Couch, F. J., Ames, M. M., Rae, J. M., Erlander, M. G., Ma, X. J., Sgroi, D. C., Reynolds, C. A., Lingle, W. L., Weinshilboum, R. M., Flockhart, D. A., Desta, Z., Perez, E. A. & Ingle, J. N., Sep 15 2008, In : Clinical Cancer Research. 14, 18, p. 5864-5868 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Effect of resveratrol on 17β-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1

Furimsky, A. M., Green, C. E., Hunt Sharp, L. E., Catz, P., Adjei, A. A., Parman, T., Kapetanovic, I. M., Weinshilboum, R. M. & Iyer, L. V., Jan 2008, In : Drug Metabolism and Disposition. 36, 1, p. 129-136 8 p.

Research output: Contribution to journalArticle

20 Scopus citations