Richard M Weinshilboum, MD

  • 26832 Citations
  • 84 Scopus h-Index
1968 …2020
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Research Output 1968 2019

2019
docetaxel
Estrogen Receptors
Single Nucleotide Polymorphism
Estrogens
Breast Neoplasms
2 Citations (Scopus)

Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A. C., Nelson, T. J., Hall-Flavin, D., Heard, K. J., Fredlender, C., Deng, Y., Elkins, J., Dani, K., Le, A. T., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Serotonergic Neurons
Neurons
Induced Pluripotent Stem Cells

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. M. & 1 others, Weinshilboum, R. M., Jan 1 2019, In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Open Access
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Breast Neoplasms
1 Citation (Scopus)

Catechol O-Methyltransferase Pharmacogenomics: Challenges and Opportunities

Ho, M. F. & Weinshilboum, R. M., Jan 1 2019, In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalComment/debate

Catechol O-Methyltransferase
Pharmacogenetics
2 Citations (Scopus)

Clopidogrel Pharmacogenetics

Pereira, N. L., Rihal, C. S., So, D. Y. F., Rosenberg, Y., Lennon, R. J., Mathew, V., Goodman, S. G., Weinshilboum, R. M., Wang, L. M., Baudhuin, L. M., Lerman, A., Hasan, A., Iturriaga, E., Fu, Y. P., Geller, N., Bailey, K. R. & Farkouh, M. E., Apr 1 2019, In : Circulation. Cardiovascular interventions. 12, 4, p. e007811

Research output: Contribution to journalArticle

clopidogrel
Pharmacogenetics
Percutaneous Coronary Intervention
Alleles
Drug Labeling

Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer

Ruddy, K. J., Schaid, D. J., Partridge, A. H., Larson, N., Batzler, A., Häberle, L., Dittrich, R., Widschwendter, P., Fink, V., Bauer, E., Schwitulla, J., Rübner, M., Ekici, A. B., Aivazova-Fuchs, V., Stewart, E. A., Beckmann, M. W., Ginsburg, E., Wang, L. M., Weinshilboum, R. M., Couch, F. J. & 4 others, Janni, W., Rack, B., Vachon, C. M. & Fasching, P. A., Jan 1 2019, (Accepted/In press) In : Fertility and Sterility.

Research output: Contribution to journalArticle

Amenorrhea
Breast Neoplasms
Drug Therapy
Menstruation
Phosphopantothenoyl-cysteine decarboxylase

Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients

Bhattacharyya, S., Ahmed, A. T., Arnold, M., Liu, D., Luo, C., Zhu, H., Mahmoudiandehkordi, S., Neavin, D., Louie, G., Dunlop, B. W., Frye, M. A., Wang, L., Weinshilboum, R. M., Krishnan, R. R., Rush, A. J. & Kaddurah-Daouk, R., Dec 1 2019, In : Translational psychiatry. 9, 1, 173.

Research output: Contribution to journalArticle

Open Access
Citalopram
Metabolomics
Outpatients
Depression
Pharmaceutical Preparations

Pharmacogenomic next-generation DNA sequencing: Lessons from the identification and functional characterization of variants of unknown significance in CYP2C9 and CYP2C19

Devarajan, S., Moon, I., Ho, M. F., Larson, N., Neavin, D. R., Moyer, A. M., Black, J. L., Bielinski, S. J., Scherer, S. E., Wang, L. M., Weinshilboum, R. M. & Reid, J. M., Apr 1 2019, In : Drug Metabolism and Disposition. 47, 4, p. 425-435 11 p.

Research output: Contribution to journalArticle

Pharmacogenetics
DNA Sequence Analysis
Cytochrome P-450 Enzyme System
Oxidoreductases
Proteins

Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine-Learning Approach With Multi-trial Replication

Athreya, A. P., Neavin, D., Carrillo-Roa, T., Skime, M., Biernacka, J. M., Frye, M. A., Rush, A. J., Wang, L., Binder, E. B., Iyer, R. K., Weinshilboum, R. M. & Bobo, W. V., Jan 1 2019, In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Pharmacogenetics
Serotonin Uptake Inhibitors
Antidepressive Agents
Major Depressive Disorder
Citalopram
3 Citations (Scopus)
Citalopram
Major Depressive Disorder
Cytochrome P-450 CYP2D6
Treatment Failure
Pharmacokinetics
1 Citation (Scopus)

Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A., Nelson, T. J., Hall-Flavin, D., Fredlender, C., Heard, K. J., Deng, Y., Le, A. T., Dave, S., Fung, L., Li, X., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Serotonin
Neurons
Synaptic Transmission

Studying treatment resistance in depression using patient derived neurons in vitro

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A., Nelson, T. J., Hall-Flavin, D., Fredlender, C., Heard, K. J., Deng, Y., Le, A. T., Dave, S., Fung, L., Li, X., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jun 1 2019, In : Molecular Psychiatry. 24, 6, 1 p.

Research output: Contribution to journalComment/debate

Neurons
Therapeutics
In Vitro Techniques
2 Citations (Scopus)

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Jan 1 2019, (Accepted/In press) In : Journal of Neural Transmission.

Research output: Contribution to journalArticle

Serotonin Uptake Inhibitors
Coronary Artery Disease
Obesity
Depression
Genes

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Cairns, J., Ingle, J. N., Kalari, K. R., Shepherd, L. E., Kubo, M., Goetz, M. P., Weinshilboum, R. M. & Wang, L. M., Apr 3 2019, In : Breast Cancer Research. 21, 1, 47.

Research output: Contribution to journalArticle

Open Access
Early Growth Response Protein 1
Lemur
Long Noncoding RNA
Aromatase Inhibitors
Protein-Tyrosine Kinases
2018
10 Citations (Scopus)

A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate-prednisone

Wang, L., Dehm, S. M., Hillman, D. W., Sicotte, H., Tan, W., Gormley, M., Bhargava, V., Jimenez, R. E., Xie, F., Yin, P., Qin, S., Quevedo, F., Costello, B., Pitot, H. C., Ho, T. H., Bryce, A. H., Ye, Z., Li, Y., Eiken, P., Vedell, P. T. & 16 others, Barman, P., McMenomy, B. P., Atwell, T. D., Carlson, R. E., Ellingson, M., Eckloff, B. W., Qin, R., Ou, F., Hart, S., Huang, H., Jen, J., Wieben, E. D., Kalari, K. R., Weinshilboum, R. M., Wang, L. & Kohli, M., Feb 1 2018, In : Annals of Oncology. 29, 2, p. 352-360 9 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Prednisone
Prostatic Neoplasms
Cell Cycle
Cell Proliferation
2 Citations (Scopus)

Association of the polygenic scores for personality traits and response to selective serotonin reuptake inhibitors in patients with major depressive disorder

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Mar 6 2018, In : Frontiers in Psychiatry. 9, MAR, 65.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Personality
Genome-Wide Association Study
Meta-Analysis
3 Citations (Scopus)

Augmentation of physician assessments with multi-omics enhances predictability of drug response: A case study of major depressive disorder

Athreya, A., Iyer, R., Neavin, D., Wang, L. M., Weinshilboum, R. M., Kaddurah-Daouk, R., Rush, J., Frye, M. A. & Bobo, W. V., Aug 1 2018, In : IEEE Computational Intelligence Magazine. 13, 3, p. 20-31 12 p., 8416980.

Research output: Contribution to journalArticle

Predictability
Augmentation
Disorder
Drugs
Metabolites
2 Citations (Scopus)

Benefits of and Barriers to Pharmacogenomics-Guided Treatment for Major Depressive Disorder

Ahmed, A. T., Weinshilboum, R. M. & Frye, M. A., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Pharmacogenetics
Major Depressive Disorder
Antidepressive Agents
Drug-Related Side Effects and Adverse Reactions
Therapeutics
10 Citations (Scopus)

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: Metabolomics-informed genomics

Liu, D., Ray, B., Neavin, D. R., Zhang, J., Athreya, A. P., Biernacka, J. M., Bobo, W. V., Hall-Flavin, D. K., Skime, M. K., Zhu, H., Jenkins, G. D., Batzler, A., Kalari, K. R., Boakye-Agyeman, F., Matson, W. R., Bhasin, S. S., Mushiroda, T., Nakamura, Y., Kubo, M., Iyer, R. K. & 4 others, Wang, L. M., Frye, M. A., Kaddurah-Daouk, R. & Weinshilboum, R. M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 56.

Research output: Contribution to journalArticle

beta-Defensins
Kynurenine
Aryl Hydrocarbon Receptors
Metabolomics
Major Depressive Disorder
19 Citations (Scopus)

BRCA1/2 Mutations and bevacizumab in the neoadjuvant treatment of breast cancer: Response and prognosis results in patients with triple-negative breast cancer From the geparquinto study

Fasching, P. A., Loibl, S., Hu, C., Hart, S., Shimelis, H., Moore, R., Schem, C., Tesch, H., Untch, M., Hilfrich, J., Rezai, M., Gerber, B., Costa, S. D., Blohmer, J. U., Fehm, T., Huober, J., Liedtke, C., Weinshilboum, R. M., Wang, L. M., Ingle, J. N. & 7 others, Müller, V., Nekljudova, V., Weber, K. E., Rack, B., Rübner, M., Von Minckwitz, G. & Couch, F. J., Aug 1 2018, In : Journal of Clinical Oncology. 36, 22, p. 2281-2287 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Neoadjuvant Therapy
Breast Neoplasms
Mutation
Disease-Free Survival
1 Citation (Scopus)

Considerations for automated machine learning in clinical metabolic profiling: Altered homocysteine plasma concentration associated with metformin exposure

Orlenko, A., Moore, J. H., Orzechowski, P., Olson, R. S., Cairns, J., Caraballo, P., Weinshilboum, R. M., Wang, L. M. & Breitenstein, M. K., Jan 1 2018, PACIFIC SYMPOSIUM ON BIOCOMPUTING 2018. 212669 ed. World Scientific Publishing Co. Pte Ltd, p. 460-471 12 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Learning systems
Plasmas
Metabolites
Feature extraction
Vitamins
7 Citations (Scopus)

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A. M., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A. III., McLaughlin, S. A., Moreno Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R. M., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

decitabine
Triple Negative Breast Neoplasms
Methyltransferases
DNA
Biomarkers
3 Citations (Scopus)

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies

Fabbri, C., Tansey, K. E., Perlis, R. H., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Breen, G., Curtis, C., Lee, S. H., Newhouse, S., Patel, H., O'Donovan, M., Lewis, G., Jenkins, G., Weinshilboum, R. M., Farmer, A. & 7 others, Aitchison, K. J., Craig, I., McGuffin, P., Schruers, K., Biernacka, J. M., Uher, R. & Lewis, C. M., Aug 1 2018, In : European Neuropsychopharmacology. 28, 8, p. 945-954 10 p.

Research output: Contribution to journalArticle

Citalopram
Genome-Wide Association Study
Cytochromes
Antidepressive Agents
Meta-Analysis
5 Citations (Scopus)

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

on behalf of the MATURA, and PAMERA & Consortia, May 25 2018, (Accepted/In press) In : Pharmacogenomics Journal. p. 1-11 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Methotrexate
Rheumatoid Arthritis
Joints
Genome

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab

Ingle, J. N., Kalari, K. R., Wickerham, D. L., Von Minckwitz, G., Fasching, P. A., Furukawa, Y., Mushiroda, T., Goetz, M. P., Barman, P., Carlson, E. E., Rastogi, P., Costantino, J. P., Cairns, J., Paik, S., Bear, H. D., Kubo, M., Wang, L. M., Wolmark, N. & Weinshilboum, R. M., Jan 1 2018, In : Pharmacogenetics and Genomics. 28, 6, p. 147-152 6 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Single Nucleotide Polymorphism
Drug Therapy
Disease-Free Survival
Genome
6 Citations (Scopus)

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

Ho, M. F., Correia, C., Ingle, J. N., Kaddurah-Daouk, R., Wang, L. M., Kaufmann, S. H. & Weinshilboum, R. M., Jun 1 2018, In : Biochemical Pharmacology. 152, p. 279-292 14 p.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA Receptors
Glutamate Receptors
Ketamine
Metabolites
1 Citation (Scopus)

Machine Learning helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer

Athreya, A. P., Gaglio, A. J., Cairns, J., Kalari, K. R., Weinshilboum, R. M., Wang, L. M., Kalbarczyk, Z. T. & Iyer, R. K., Jun 29 2018, (Accepted/In press) In : IEEE Transactions on Nanobioscience.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Learning systems
Genes
Metformin
Pharmaceutical Preparations
1 Citation (Scopus)

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

The Mood Disorders Precision Medicine Consortium (MDPMC), Oct 1 2018, In : Journal of Affective Disorders. 238, p. 1-7 7 p.

Research output: Contribution to journalArticle

Mood Disorders
Depression
Phenotype
Research
Anxiety
9 Citations (Scopus)

New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR∗D studies: Rare variant analysis and high-density imputation

Fabbri, C., Tansey, K. E., Perlis, R. H., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Breen, G., Curtis, C., Sang-Hyuk, L., Newhouse, S., Patel, H., Guipponi, M., Perroud, N., Bondolfi, G., O'Donovan, M., Lewis, G. & 8 others, Biernacka, J. M., Weinshilboum, R. M., Farmer, A., Aitchison, K. J., Craig, I., McGuffin, P., Uher, R. & Lewis, C. M., May 22 2018, In : Pharmacogenomics Journal. 18, 3, p. 413-421 9 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Antidepressive Agents
Gene Ontology
Exome
Single Nucleotide Polymorphism
2 Citations (Scopus)

Pathway-based analysis of genome-wide association data identified SNPs in HMMR as biomarker for chemotherapy- induced neutropenia in breast cancer patients

Bidadi, B., Liu, D., Kalari, K. R., Rubner, M., Hein, A., Beckmann, M. W., Rack, B., Janni, W., Fasching, P. A., Weinshilboum, R. M. & Wang, L. M., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 158.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Neutropenia
Single Nucleotide Polymorphism
Biomarkers
Breast Neoplasms
5 Citations (Scopus)

Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: Meta-analysis of three treatment cohorts

Ward, J., Graham, N., Strawbridge, R. J., Ferguson, A., Jenkins, G., Chen, W., Hodgson, K., Frye, M. A., Weinshilboum, R. M., Uher, R., Lewis, C. M., Biernacka, J. M. & Smith, D. J., Sep 1 2018, In : PLoS One. 13, 9, e0203896.

Research output: Contribution to journalArticle

antidepressants
Major Depressive Disorder
meta-analysis
Antidepressive Agents
Meta-Analysis
14 Citations (Scopus)

Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects

Volpi, S., Bult, C. J., Chisholm, R. L., Deverka, P. A., Ginsburg, G. S., Jacob, H. J., Kasapi, M., McLeod, H. L., Roden, D. M., Williams, M. S., Green, E. D., Rodriguez, L. L., Aronson, S., Cavallari, L. H., Denny, J. C., Dressler, L. G., Johnson, J. A., Klein, T. E., Leeder, J. S., Piquette-Miller, M. & 12 others, Perera, M., Rasmussen-Torvik, L. J., Rehm, H. L., Ritchie, M. D., Skaar, T. C., Wagle, N., Weinshilboum, R. M., Weitzel, K. W., Wildin, R., Wilson, J., Manolio, T. A. & Relling, M. V., May 1 2018, In : Clinical Pharmacology and Therapeutics. 103, 5, p. 778-786 9 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Research
Pharmaceutical Preparations
Precision Medicine
Drug-Related Side Effects and Adverse Reactions
2 Citations (Scopus)
Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Response Elements
Xenobiotics
Single Nucleotide Polymorphism
1 Citation (Scopus)

SLCO1B1 genetic variation and hormone therapy in menopausal women

Moyer, A. M., De Andrade, M., Faubion, S. S., Kapoor, E., Dudenkov, T., Weinshilboum, R. M. & Miller, V. M., Aug 1 2018, In : Menopause (New York, N.Y.). 25, 8, p. 877-882 6 p.

Research output: Contribution to journalArticle

Hormones
Sweat
Estrogens
Genotype
Therapeutics
1 Citation (Scopus)

TCL1A, a novel transcription factor and a coregulator of nuclear factor kB p65: Single nucleotide polymorphism and estrogen dependences

Ho, M. F., Lummertz da Rocha, E., Zhang, C., Ingle, J. N., Goss, P. E., Shepherd, L. E., Kubo, M., Wang, L. M., Li, H. & Weinshilboum, R. M., Jun 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 700-710 11 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
Single Nucleotide Polymorphism
Estrogens
Transcription Factors
RNA Sequence Analysis
2 Citations (Scopus)

The role of the aryl hydrocarbon receptor (AHR) in immune and inflammatory diseases

Neavin, D. R., Liu, D., Ray, B. & Weinshilboum, R. M., Dec 1 2018, In : International Journal of Molecular Sciences. 19, 12, 3851.

Research output: Contribution to journalReview article

Aryl Hydrocarbon Receptors
Immune System Diseases
hydrocarbons
Hydrocarbons
Nucleotides
2017
8 Citations (Scopus)

A comprehensive analysis of breast cancer microbiota and host gene expression

Thompson, K. J., Ingle, J. N., Tang, X., Chia, N. D., Jeraldo, P. R., Walther-Antonio, M., Kandimalla, K. K., Johnson, S., Yao, J. Z., Harrington, S. C., Suman, V. J., Wang, L. M., Weinshilboum, R. M., Boughey, J. C., Kocher, J-P., Nelson, H., Goetz, M. P. & Kalari, K. R., Nov 1 2017, In : PLoS One. 12, 11, e0188873.

Research output: Contribution to journalArticle

Microbiota
Gene expression
breast neoplasms
Tumors
Breast Neoplasms
8 Citations (Scopus)

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

Qin, S., Ingle, J. N., Liu, M., Yu, J., Wickerham, D. L., Kubo, M., Weinshilboum, R. M. & Wang, L. M., Aug 18 2017, In : Breast Cancer Research. 19, 1, 95.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Estrogen Receptor alpha
Calmodulin
Single Nucleotide Polymorphism
Estrogens
2 Citations (Scopus)

Clinical validation of genetic variants associated with in vitro chemotherapy-related lymphoblastoid cell toxicity

Fasching, P. A., Häberle, L., Rack, B., Li, L., Hein, A., Ekici, A. B., Reis, A., Lux, M. P., Cunningham, J. M., Ruebner, M., Jenkins, G., Fridley, B., Schneeweiss, A., Tesch, H., Lichtenegger, W., Fehm, T., Heinrich, G., Rezai, M., Beckmann, M. W., Janni, W. & 2 others, Weinshilboum, R. M. & Wang, L. M., 2017, In : Oncotarget. 8, 44, p. 78133-78143 11 p.

Research output: Contribution to journalArticle

docetaxel
gemcitabine
Single Nucleotide Polymorphism
Drug Therapy
Epirubicin
1 Citation (Scopus)

Data-driven longitudinal modeling and prediction of symptom dynamics in major depressive disorder: Integrating factor graphs and learning methods

Athreya, A. P., Banerjee, S. S., Neavin, D., Kaddurah-Daouk, R., Rush, A. J., Frye, M. A., Wang, L. M., Weinshilboum, R. M., Bobo, W. V. & Iyer, R. K., Oct 4 2017, 2017 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2017. Institute of Electrical and Electronics Engineers Inc., 8058559

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Integrating Factor
Factor Graph
Major Depressive Disorder
Data-driven
Antidepressive Agents
16 Citations (Scopus)
Clinical Decision Support Systems
Electronic Health Records
Pharmacogenetics
Precision Medicine
Cognition
10 Citations (Scopus)

Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

Yu, J., Qin, B., Moyer, A. M., Sinnwell, J. P., Thompson, K. J., Copland, J. A. III., Marlow, L. A., Miller, J. L., Yin, P., Gao, B., Minter-Dykhouse, K., Tang, X., McLaughlin, S. A., Moreno Aspitia, A., Schweitzer, A., Lu, Y., Hubbard, J., Northfelt, D. W., Gray, R. J., Hunt, K. & 10 others, Conners, A. L., Suman, V. J., Kalari, K. R., Ingle, J. N., Lou, Z., Visscher, D. W., Weinshilboum, R. M., Boughey, J. C., Goetz, M. P. & Wang, L. M., Dec 6 2017, In : Breast cancer research : BCR. 19, 1, 1 p.

Research output: Contribution to journalArticle

Heterografts
Breast Neoplasms
Biopsy
Drug Therapy
Neoplasms
2 Citations (Scopus)

Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: Applications of a proteomic informed genomic approach

Nassan, M., Jia, Y. F., Jenkins, G., Colby, C., Feeder, S., Choi, D. S., Veldic, M. D., McElroy, S. L., Bond, D. J., Weinshilboum, R. M., Biernacka, J. M. & Frye, M. A., Dec 1 2017, In : Journal of Psychiatric Research. 95, p. 208-212 5 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Proteomics
Quantitative Trait Loci
Alleles
Proteins
27 Citations (Scopus)

Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine

Giacomini, K. M., Yee, S. W., Mushiroda, T., Weinshilboum, R. M., Ratain, M. J. & Kubo, M., Jan 1 2017, In : Nature reviews. Drug discovery. 16, 1, p. 1 1 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pharmacogenetics
Genetic Predisposition to Disease
Drug-Related Side Effects and Adverse Reactions
Medicine
2 Citations (Scopus)

Life-iNet: A structured network-based knowledge exploration and analytics system for life sciences

Ren, X., Shen, J., Qu, M., Wang, X., Wu, Z., Zhu, Q., Jiang, M., Tao, F., Sinha, S., Liem, D., Ping, P., Weinshilboum, R. M. & Han, J., Jan 1 2017, ACL 2017 - 55th Annual Meeting of the Association for Computational Linguistics, Proceedings of System Demonstrations. Association for Computational Linguistics (ACL), p. 55-60 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

life sciences
Search engines
search engine
Tar
functionality
4 Citations (Scopus)

Model-based unsupervised learning informs metformininduced cell-migration inhibition through an AMPK-independent mechanism in breast cancer

Athreya, A. P., Kalari, K. R., Cairns, J., Gaglio, A. J., Wills, Q. F., Niu, N., Weinshilboum, R. M., Iyer, R. K. & Wang, L. M., 2017, In : Oncotarget. 8, 16, p. 27199-27215 17 p.

Research output: Contribution to journalArticle

Cell Migration Inhibition
AMP-Activated Protein Kinases
Metformin
Learning
Breast Neoplasms
24 Citations (Scopus)

Multidisciplinary model to implement pharmacogenomics at the point of care

Caraballo, P., Hodge, L. S., Bielinski, S. J., Stewart, A. K., Farrugia, G., Schultz, C. G., Rohrer-Vitek, C. R., Olson, J. E., St. Sauver, J., Roger, V. L., Parkulo, M. A., Kullo, I. J., Nicholson, W. T., Elliott, M. A., Black, J. L. & Weinshilboum, R. M., Apr 1 2017, In : Genetics in Medicine. 19, 4, p. 421-429 9 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Clinical Decision Support Systems
Pharmacogenetics
Drug Interactions
Clinical Governance
3 Citations (Scopus)

Pharmacogenomic Discovery to Function and Mechanism: Breast Cancer as a Case Study

Wang, L. M., Ingle, J. & Weinshilboum, R. M., Jan 1 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pharmacogenetics
Breast Neoplasms
Clinical Pharmacology
Research
15 Citations (Scopus)

Pharmacogenomics: Precision Medicine and Drug Response

Weinshilboum, R. M. & Wang, L. M., Nov 1 2017, In : Mayo Clinic Proceedings. 92, 11, p. 1711-1722 12 p.

Research output: Contribution to journalReview article

Precision Medicine
Pharmacogenetics
Pharmaceutical Preparations
Electronic Health Records
Human Genome
15 Citations (Scopus)

Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies

Tamm, R., Mägi, R., Tremmel, R., Winter, S., Mihailov, E., Smid, A., Möricke, A., Klein, K., Schrappe, M., Stanulla, M., Houlston, R., Weinshilboum, R. M., Mlinarič Raščan, I., Metspalu, A., Milani, L., Schwab, M. & Schaeffeler, E., 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

thiopurine methyltransferase
Genome-Wide Association Study
Meta-Analysis
Phenotype
6-Mercaptopurine