Richard M Weinshilboum, MD

  • 27439 Citations
  • 84 Scopus h-Index
1968 …2020
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Research Output 1968 2020

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Article
2020

Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes

The Mood Disorders Precision Medicine Consortium (MDPMC), Mar 1 2020, In : Journal of Affective Disorders. 264, p. 90-97 8 p.

Research output: Contribution to journalArticle

Open Access
Metabolomics
Phenotype
Citalopram
Major Depressive Disorder
acylcarnitine
2019
docetaxel
Estrogen Receptors
Single Nucleotide Polymorphism
Estrogens
Breast Neoplasms
2 Citations (Scopus)

Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A. C., Nelson, T. J., Hall-Flavin, D., Heard, K. J., Fredlender, C., Deng, Y., Elkins, J., Dani, K., Le, A. T., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Serotonergic Neurons
Neurons
Induced Pluripotent Stem Cells

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. M. & 1 others, Weinshilboum, R. M., Jan 1 2019, In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Open Access
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Breast Neoplasms
3 Citations (Scopus)

Clopidogrel Pharmacogenetics

Pereira, N. L., Rihal, C., So, D. Y. F., Rosenberg, Y., Lennon, R. J., Mathew, V., Goodman, S. G., Weinshilboum, R. M., Wang, L. M., Baudhuin, L. M., Lerman, A., Hasan, A., Iturriaga, E., Fu, Y. P., Geller, N., Bailey, K. R. & Farkouh, M. E., Apr 1 2019, In : Circulation. Cardiovascular interventions. 12, 4, p. e007811

Research output: Contribution to journalArticle

clopidogrel
Pharmacogenetics
Percutaneous Coronary Intervention
Alleles
Drug Labeling
1 Citation (Scopus)
Technetium Tc 99m Sestamibi
Molecular Imaging
Breast
Breast Neoplasms
Drug Therapy

Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer

Ingle, J. N., Kalari, K. R., Momozawa, Y., Kubo, M., Furukawa, Y., Shepherd, L. E., Ellis, M. J., Goss, P. E., Barman, P., Carlson, E. E., Sinnwell, J. P., Tang, X., Goetz, M. P., Chen, B. E., Cairns, J., Weinshilboum, R. M. & Wang, L. M., Oct 1 2019, In : Pharmacogenetics and genomics. 29, 8, p. 183-191 9 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Breast Neoplasms

Dual Roles for the TSPYL Family in Mediating Serotonin Transport and the Metabolism of Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder

Qin, S., Eugene, A. R., Liu, D., Zhang, L., Neavin, D., Biernacka, J. M., Yu, J., Weinshilboum, R. M. & Wang, L., Jan 1 2019, (Accepted/In press) In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Open Access
Major Depressive Disorder
Serotonin Uptake Inhibitors
Citalopram
Testis
Serotonin

Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer

Ruddy, K. J., Schaid, D. J., Partridge, A. H., Larson, N. B., Batzler, A., Häberle, L., Dittrich, R., Widschwendter, P., Fink, V., Bauer, E., Schwitulla, J., Rübner, M., Ekici, A. B., Aivazova-Fuchs, V., Stewart, E. A., Beckmann, M. W., Ginsburg, E., Wang, L., Weinshilboum, R. M., Couch, F. J. & 4 others, Janni, W., Rack, B., Vachon, C. & Fasching, P. A., Jan 1 2019, (Accepted/In press) In : Fertility and Sterility.

Research output: Contribution to journalArticle

Amenorrhea
Breast Neoplasms
Drug Therapy
Menstruation
Phosphopantothenoyl-cysteine decarboxylase
Open Access
Ketamine
Microglia
Transducers
Interferons
Transcriptional Activation
1 Citation (Scopus)

Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients

Bhattacharyya, S., Ahmed, A. T., Arnold, M., Liu, D., Luo, C., Zhu, H., Mahmoudiandehkordi, S., Neavin, D., Louie, G., Dunlop, B. W., Frye, M. A., Wang, L., Weinshilboum, R. M., Krishnan, R. R., Rush, A. J. & Kaddurah-Daouk, R., Dec 1 2019, In : Translational psychiatry. 9, 1, 173.

Research output: Contribution to journalArticle

Open Access
Citalopram
Metabolomics
Outpatients
Depression
Pharmaceutical Preparations
2 Citations (Scopus)

Pharmacogenomic next-generation DNA sequencing: Lessons from the identification and functional characterization of variants of unknown significance in CYP2C9 and CYP2C19

Devarajan, S., Moon, I., Ho, M. F., Larson, N., Neavin, D. R., Moyer, A., Black, J. L., Bielinski, S. J., Scherer, S. E., Wang, L. M., Weinshilboum, R. M. & Reid, J. M., Apr 1 2019, In : Drug Metabolism and Disposition. 47, 4, p. 425-435 11 p.

Research output: Contribution to journalArticle

Pharmacogenetics
DNA Sequence Analysis
Cytochrome P-450 Enzyme System
Oxidoreductases
Proteins
5 Citations (Scopus)

Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine-Learning Approach With Multi-trial Replication

Athreya, A. P., Neavin, D., Carrillo-Roa, T., Skime, M., Biernacka, J., Frye, M. A., Rush, A. J., Wang, L., Binder, E. B., Iyer, R. K., Weinshilboum, R. M. & Bobo, W. V., Jan 1 2019, In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Pharmacogenetics
Serotonin Uptake Inhibitors
Antidepressive Agents
Major Depressive Disorder
Citalopram
3 Citations (Scopus)
Citalopram
Major Depressive Disorder
Cytochrome P-450 CYP2D6
Treatment Failure
Pharmacokinetics

Pilot Study of Metabolomic Clusters as State Markers of Major Depression and Outcomes to CBT Treatment

Bhattacharyya, S., Dunlop, B. W., Mahmoudiandehkordi, S., Ahmed, A. T., Louie, G., Frye, M. A., Weinshilboum, R. M., Krishnan, R. R., Rush, A. J., Mayberg, H. S., Craighead, W. E. & Kaddurah-Daouk, R., Sep 12 2019, In : Frontiers in Neuroscience. 13, 926.

Research output: Contribution to journalArticle

Open Access
Metabolomics
Cognitive Therapy
Major Depressive Disorder
Depression
Therapeutics
4 Citations (Scopus)

Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons

Vadodaria, K. C., Ji, Y., Skime, M., Paquola, A., Nelson, T. J., Hall-Flavin, D., Fredlender, C., Heard, K. J., Deng, Y., Le, A. T., Dave, S., Fung, L., Li, X., Marchetto, M. C., Weinshilboum, R. M. & Gage, F. H., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Serotonin
Neurons
Synaptic Transmission
Open Access
Aryl Hydrocarbon Receptors
Quantitative Trait Loci
Single Nucleotide Polymorphism
Binding Sites
Ligands
1 Citation (Scopus)

Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene

Bodkin, J. A., Coleman, M. J., Godfrey, L. J., Carvalho, C. M. B., Morgan, C. J., Suckow, R. F., Anderson, T., Öngür, D., Kaufman, M. J., Lewandowski, K. E., Siegel, A. J., Waldstreicher, E., Grochowski, C. M., Javitt, D. C., Rujescu, D., Hebbring, S., Weinshilboum, R., Rodriguez, S. B., Kirchhoff, C., Visscher, T. & 11 others, Vuckovic, A., Fialkowski, A., McCarthy, S., Malhotra, D., Sebat, J., Goff, D. C., Hudson, J. I., Lupski, J. R., Coyle, J. T., Rudolph, U. & Levy, D. L., Oct 1 2019, In : Biological psychiatry. 86, 7, p. 523-535 13 p.

Research output: Contribution to journalArticle

Glycine Dehydrogenase (Decarboxylating)
N-Methyl-D-Aspartate Receptors
Psychotic Disorders
Glycine
Cycloserine
2 Citations (Scopus)

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Jan 1 2019, (Accepted/In press) In : Journal of Neural Transmission.

Research output: Contribution to journalArticle

Serotonin Uptake Inhibitors
Coronary Artery Disease
Obesity
Depression
Genes
2 Citations (Scopus)

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Cairns, J., Ingle, J. N., Kalari, K. R., Shepherd, L. E., Kubo, M., Goetz, M. P., Weinshilboum, R. M. & Wang, L. M., Apr 3 2019, In : Breast Cancer Research. 21, 1, 47.

Research output: Contribution to journalArticle

Open Access
Early Growth Response Protein 1
Lemur
Long Noncoding RNA
Aromatase Inhibitors
Protein-Tyrosine Kinases
2018
12 Citations (Scopus)

A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate-prednisone

Wang, L., Dehm, S. M., Hillman, D. W., Sicotte, H., Tan, W., Gormley, M., Bhargava, V., Jimenez, R. E., Xie, F., Yin, P., Qin, S., Quevedo, F., Costello, B., Pitot, H. C., Ho, T. H., Bryce, A. H., Ye, Z., Li, Y., Eiken, P., Vedell, P. T. & 16 others, Barman, P., McMenomy, B. P., Atwell, T. D., Carlson, R. E., Ellingson, M., Eckloff, B. W., Qin, R., Ou, F., Hart, S., Huang, H., Jen, J., Wieben, E. D., Kalari, K. R., Weinshilboum, R. M., Wang, L. & Kohli, M., Feb 1 2018, In : Annals of Oncology. 29, 2, p. 352-360 9 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Prednisone
Prostatic Neoplasms
Cell Cycle
Cell Proliferation
6 Citations (Scopus)

Association of the polygenic scores for personality traits and response to selective serotonin reuptake inhibitors in patients with major depressive disorder

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Mar 6 2018, In : Frontiers in Psychiatry. 9, MAR, 65.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Personality
Genome-Wide Association Study
Meta-Analysis
4 Citations (Scopus)

Augmentation of physician assessments with multi-omics enhances predictability of drug response: A case study of major depressive disorder

Athreya, A., Iyer, R., Neavin, D., Wang, L. M., Weinshilboum, R. M., Kaddurah-Daouk, R., Rush, J., Frye, M. A. & Bobo, W. V., Aug 1 2018, In : IEEE Computational Intelligence Magazine. 13, 3, p. 20-31 12 p., 8416980.

Research output: Contribution to journalArticle

Predictability
Augmentation
Disorder
Drugs
Metabolites
3 Citations (Scopus)

Benefits of and Barriers to Pharmacogenomics-Guided Treatment for Major Depressive Disorder

Ahmed, A. T., Weinshilboum, R. M. & Frye, M. A., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Pharmacogenetics
Major Depressive Disorder
Antidepressive Agents
Drug-Related Side Effects and Adverse Reactions
Therapeutics
11 Citations (Scopus)

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: Metabolomics-informed genomics

Liu, D., Ray, B., Neavin, D. R., Zhang, J., Athreya, A. P., Biernacka, J. M., Bobo, W. V., Hall-Flavin, D. K., Skime, M. K., Zhu, H., Jenkins, G. D., Batzler, A., Kalari, K. R., Boakye-Agyeman, F., Matson, W. R., Bhasin, S. S., Mushiroda, T., Nakamura, Y., Kubo, M., Iyer, R. K. & 4 others, Wang, L. M., Frye, M. A., Kaddurah-Daouk, R. & Weinshilboum, R. M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 56.

Research output: Contribution to journalArticle

beta-Defensins
Kynurenine
Aryl Hydrocarbon Receptors
Metabolomics
Major Depressive Disorder
23 Citations (Scopus)

BRCA1/2 Mutations and bevacizumab in the neoadjuvant treatment of breast cancer: Response and prognosis results in patients with triple-negative breast cancer From the geparquinto study

Fasching, P. A., Loibl, S., Hu, C., Hart, S., Shimelis, H., Moore, R., Schem, C., Tesch, H., Untch, M., Hilfrich, J., Rezai, M., Gerber, B., Costa, S. D., Blohmer, J. U., Fehm, T., Huober, J., Liedtke, C., Weinshilboum, R. M., Wang, L. M., Ingle, J. N. & 7 others, Müller, V., Nekljudova, V., Weber, K. E., Rack, B., Rübner, M., Von Minckwitz, G. & Couch, F. J., Aug 1 2018, In : Journal of Clinical Oncology. 36, 22, p. 2281-2287 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Neoadjuvant Therapy
Breast Neoplasms
Mutation
Disease-Free Survival
15 Citations (Scopus)

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A. III., McLaughlin, S. A., Moreno Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R. M., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

decitabine
Triple Negative Breast Neoplasms
Methyltransferases
DNA
Biomarkers
6 Citations (Scopus)

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies

Fabbri, C., Tansey, K. E., Perlis, R. H., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Breen, G., Curtis, C., Lee, S. H., Newhouse, S., Patel, H., O'Donovan, M., Lewis, G., Jenkins, G., Weinshilboum, R. M., Farmer, A. & 7 others, Aitchison, K. J., Craig, I., McGuffin, P., Schruers, K., Biernacka, J. M., Uher, R. & Lewis, C. M., Aug 1 2018, In : European Neuropsychopharmacology. 28, 8, p. 945-954 10 p.

Research output: Contribution to journalArticle

Citalopram
Genome-Wide Association Study
Cytochromes
Antidepressive Agents
Meta-Analysis
11 Citations (Scopus)

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

on behalf of the MATURA, and PAMERA & Consortia, May 25 2018, (Accepted/In press) In : Pharmacogenomics Journal. p. 1-11 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Methotrexate
Rheumatoid Arthritis
Joints
Genome

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab

Ingle, J. N., Kalari, K. R., Wickerham, D. L., Von Minckwitz, G., Fasching, P. A., Furukawa, Y., Mushiroda, T., Goetz, M. P., Barman, P., Carlson, E. E., Rastogi, P., Costantino, J. P., Cairns, J., Paik, S., Bear, H. D., Kubo, M., Wang, L. M., Wolmark, N. & Weinshilboum, R. M., Jan 1 2018, In : Pharmacogenetics and Genomics. 28, 6, p. 147-152 6 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Single Nucleotide Polymorphism
Drug Therapy
Disease-Free Survival
Genome
7 Citations (Scopus)

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

Ho, M. F., Correia, C., Ingle, J. N., Kaddurah-Daouk, R., Wang, L. M., Kaufmann, S. H. & Weinshilboum, R. M., Jun 1 2018, In : Biochemical Pharmacology. 152, p. 279-292 14 p.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA Receptors
Glutamate Receptors
Ketamine
Metabolites
3 Citations (Scopus)

Machine Learning helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer

Athreya, A. P., Gaglio, A. J., Cairns, J., Kalari, K. R., Weinshilboum, R. M., Wang, L. M., Kalbarczyk, Z. T. & Iyer, R. K., Jun 29 2018, (Accepted/In press) In : IEEE Transactions on Nanobioscience.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Learning systems
Genes
Metformin
Pharmaceutical Preparations
2 Citations (Scopus)

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

The Mood Disorders Precision Medicine Consortium (MDPMC), Oct 1 2018, In : Journal of Affective Disorders. 238, p. 1-7 7 p.

Research output: Contribution to journalArticle

Mood Disorders
Depression
Phenotype
Research
Anxiety
10 Citations (Scopus)

New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR∗D studies: Rare variant analysis and high-density imputation

Fabbri, C., Tansey, K. E., Perlis, R. H., Hauser, J., Henigsberg, N., Maier, W., Mors, O., Placentino, A., Rietschel, M., Souery, D., Breen, G., Curtis, C., Sang-Hyuk, L., Newhouse, S., Patel, H., Guipponi, M., Perroud, N., Bondolfi, G., O'Donovan, M., Lewis, G. & 8 others, Biernacka, J. M., Weinshilboum, R. M., Farmer, A., Aitchison, K. J., Craig, I., McGuffin, P., Uher, R. & Lewis, C. M., May 22 2018, In : Pharmacogenomics Journal. 18, 3, p. 413-421 9 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Antidepressive Agents
Gene Ontology
Exome
Single Nucleotide Polymorphism
3 Citations (Scopus)

Pathway-based analysis of genome-wide association data identified SNPs in HMMR as biomarker for chemotherapy- induced neutropenia in breast cancer patients

Bidadi, B., Liu, D., Kalari, K. R., Rubner, M., Hein, A., Beckmann, M. W., Rack, B., Janni, W., Fasching, P. A., Weinshilboum, R. M. & Wang, L. M., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 158.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Neutropenia
Single Nucleotide Polymorphism
Biomarkers
Breast Neoplasms
7 Citations (Scopus)

Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: Meta-analysis of three treatment cohorts

Ward, J., Graham, N., Strawbridge, R. J., Ferguson, A., Jenkins, G., Chen, W., Hodgson, K., Frye, M. A., Weinshilboum, R. M., Uher, R., Lewis, C. M., Biernacka, J. M. & Smith, D. J., Sep 1 2018, In : PLoS One. 13, 9, e0203896.

Research output: Contribution to journalArticle

antidepressants
Major Depressive Disorder
meta-analysis
Antidepressive Agents
Meta-Analysis
26 Citations (Scopus)

Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects

Volpi, S., Bult, C. J., Chisholm, R. L., Deverka, P. A., Ginsburg, G. S., Jacob, H. J., Kasapi, M., McLeod, H. L., Roden, D. M., Williams, M. S., Green, E. D., Rodriguez, L. L., Aronson, S., Cavallari, L. H., Denny, J. C., Dressler, L. G., Johnson, J. A., Klein, T. E., Leeder, J. S., Piquette-Miller, M. & 12 others, Perera, M., Rasmussen-Torvik, L. J., Rehm, H. L., Ritchie, M. D., Skaar, T. C., Wagle, N., Weinshilboum, R. M., Weitzel, K. W., Wildin, R., Wilson, J., Manolio, T. A. & Relling, M. V., May 1 2018, In : Clinical Pharmacology and Therapeutics. 103, 5, p. 778-786 9 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Research
Pharmaceutical Preparations
Precision Medicine
Drug-Related Side Effects and Adverse Reactions
2 Citations (Scopus)
Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Response Elements
Xenobiotics
Single Nucleotide Polymorphism
2 Citations (Scopus)

SLCO1B1 genetic variation and hormone therapy in menopausal women

Moyer, A., De Andrade, M., Faubion, S. S., Kapoor, E., Dudenkov, T., Weinshilboum, R. M. & Miller, V. M., Aug 1 2018, In : Menopause (New York, N.Y.). 25, 8, p. 877-882 6 p.

Research output: Contribution to journalArticle

Hormones
Sweat
Estrogens
Genotype
Therapeutics
1 Citation (Scopus)

TCL1A, a novel transcription factor and a coregulator of nuclear factor kB p65: Single nucleotide polymorphism and estrogen dependences

Ho, M. F., Lummertz da Rocha, E., Zhang, C., Ingle, J. N., Goss, P. E., Shepherd, L. E., Kubo, M., Wang, L. M., Li, H. & Weinshilboum, R. M., Jun 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 700-710 11 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
Single Nucleotide Polymorphism
Estrogens
Transcription Factors
RNA Sequence Analysis
2017
10 Citations (Scopus)

A comprehensive analysis of breast cancer microbiota and host gene expression

Thompson, K. J., Ingle, J. N., Tang, X., Chia, N. D., Jeraldo, P. R., Walther-Antonio, M., Kandimalla, K. K., Johnson, S., Yao, J. Z., Harrington, S. C., Suman, V. J., Wang, L. M., Weinshilboum, R. M., Boughey, J. C., Kocher, J-P., Nelson, H., Goetz, M. P. & Kalari, K. R., Nov 1 2017, In : PLoS One. 12, 11, e0188873.

Research output: Contribution to journalArticle

Microbiota
Gene expression
breast neoplasms
Tumors
Breast Neoplasms
10 Citations (Scopus)

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

Qin, S., Ingle, J. N., Liu, M., Yu, J., Wickerham, D. L., Kubo, M., Weinshilboum, R. M. & Wang, L. M., Aug 18 2017, In : Breast Cancer Research. 19, 1, 95.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Estrogen Receptor alpha
Calmodulin
Single Nucleotide Polymorphism
Estrogens
2 Citations (Scopus)

Clinical validation of genetic variants associated with in vitro chemotherapy-related lymphoblastoid cell toxicity

Fasching, P. A., Häberle, L., Rack, B., Li, L., Hein, A., Ekici, A. B., Reis, A., Lux, M. P., Cunningham, J. M., Ruebner, M., Jenkins, G., Fridley, B., Schneeweiss, A., Tesch, H., Lichtenegger, W., Fehm, T., Heinrich, G., Rezai, M., Beckmann, M. W., Janni, W. & 2 others, Weinshilboum, R. M. & Wang, L. M., 2017, In : Oncotarget. 8, 44, p. 78133-78143 11 p.

Research output: Contribution to journalArticle

docetaxel
gemcitabine
Single Nucleotide Polymorphism
Drug Therapy
Epirubicin
13 Citations (Scopus)

Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

Yu, J., Qin, B., Moyer, A., Sinnwell, J. P., Thompson, K. J., Copland, J. A. III., Marlow, L. A., Miller, J. L., Yin, P., Gao, B., Minter-Dykhouse, K., Tang, X., McLaughlin, S. A., Moreno Aspitia, A., Schweitzer, A., Lu, Y., Hubbard, J., Northfelt, D. W., Gray, R. J., Hunt, K. & 10 others, Conners, A. L., Suman, V. J., Kalari, K. R., Ingle, J. N., Lou, Z., Visscher, D. W., Weinshilboum, R. M., Boughey, J. C., Goetz, M. P. & Wang, L. M., Dec 6 2017, In : Breast cancer research : BCR. 19, 1, 1 p.

Research output: Contribution to journalArticle

Heterografts
Breast Neoplasms
Biopsy
Drug Therapy
Neoplasms
2 Citations (Scopus)

Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: Applications of a proteomic informed genomic approach

Nassan, M., Jia, Y. F., Jenkins, G., Colby, C., Feeder, S., Choi, D. S., Veldic, M. D., McElroy, S. L., Bond, D. J., Weinshilboum, R. M., Biernacka, J. M. & Frye, M. A., Dec 1 2017, In : Journal of Psychiatric Research. 95, p. 208-212 5 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Proteomics
Quantitative Trait Loci
Alleles
Proteins
31 Citations (Scopus)

Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine

Giacomini, K. M., Yee, S. W., Mushiroda, T., Weinshilboum, R. M., Ratain, M. J. & Kubo, M., Jan 1 2017, In : Nature reviews. Drug discovery. 16, 1, p. 1 1 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pharmacogenetics
Genetic Predisposition to Disease
Drug-Related Side Effects and Adverse Reactions
Medicine
4 Citations (Scopus)

Model-based unsupervised learning informs metformininduced cell-migration inhibition through an AMPK-independent mechanism in breast cancer

Athreya, A. P., Kalari, K. R., Cairns, J., Gaglio, A. J., Wills, Q. F., Niu, N., Weinshilboum, R. M., Iyer, R. K. & Wang, L. M., 2017, In : Oncotarget. 8, 16, p. 27199-27215 17 p.

Research output: Contribution to journalArticle

Cell Migration Inhibition
AMP-Activated Protein Kinases
Metformin
Learning
Breast Neoplasms
26 Citations (Scopus)

Multidisciplinary model to implement pharmacogenomics at the point of care

Caraballo, P., Hodge, L. S., Bielinski, S. J., Stewart, A. K., Farrugia, G., Schultz, C. G., Rohrer-Vitek, C. R., Olson, J. E., St. Sauver, J., Roger, V. L., Parkulo, M. A., Kullo, I. J., Nicholson, W. T., Elliott, M. A., Black, J. L. & Weinshilboum, R. M., Apr 1 2017, In : Genetics in Medicine. 19, 4, p. 421-429 9 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Clinical Decision Support Systems
Pharmacogenetics
Drug Interactions
Clinical Governance
3 Citations (Scopus)

Pharmacogenomic Discovery to Function and Mechanism: Breast Cancer as a Case Study

Wang, L. M., Ingle, J. & Weinshilboum, R. M., Jan 1 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pharmacogenetics
Breast Neoplasms
Clinical Pharmacology
Research
17 Citations (Scopus)

Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies

Tamm, R., Mägi, R., Tremmel, R., Winter, S., Mihailov, E., Smid, A., Möricke, A., Klein, K., Schrappe, M., Stanulla, M., Houlston, R., Weinshilboum, R. M., Mlinarič Raščan, I., Metspalu, A., Milani, L., Schwab, M. & Schaeffeler, E., 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

thiopurine methyltransferase
Genome-Wide Association Study
Meta-Analysis
Phenotype
6-Mercaptopurine