Richard M Weinshilboum, MD

  • 28270 Citations
  • 85 Scopus h-Index
1968 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2003

Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: Gene resequencing and functional genomics

Adjei, A. A., Thomae, B. A., Prondzinski, J. L., Eckloff, B. W., Wieben, E. D. & Weinshilboum, R. M., Aug 2003, In : British Journal of Pharmacology. 139, 8, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Inheritance and drug response

Weinshilboum, R., Feb 6 2003, In : New England Journal of Medicine. 348, 6, p. 529-537 9 p.

Research output: Contribution to journalReview article

853 Scopus citations

Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia

Schmiegelow, K., Björk, O., Glomstein, A., Gustafsson, G., Keiding, N., Kristinsson, J., Mäkipernaa, A., Rosthøj, S., Szumlanski, C., Sørensen, T. M. & Weinshilboum, R., Apr 1 2003, In : Journal of Clinical Oncology. 21, 7, p. 1332-1339 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

L-DOPA biotransformation: Correlations of dosage, erythrocyte catechol O-methyltransferase and platelet SULT1A3 activities with metabolic pathways in Parkinsonian patients

Dousa, M. K., Weinshilboum, R. M., Muenter, M. D., Offord, K. P., Decker, P. A. & Tyce, G. M., Aug 1 2003, In : Journal of Neural Transmission. 110, 8, p. 899-910 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pharmacogenetics [7] (multiple letters)

Padrini, R., Ferrari, M., Carnes, M., Noah, L., Weinshilboum, R. M., Evans, W. E., McLeod, H. L., Goldstein, D. B. & Vallance, P., May 15 2003, In : New England Journal of Medicine. 348, 20, p. 2041-2043 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pharmacogenetics of human 3′-phosphoadenosine 5′-phosphosulfate synthetase 1 (PAPSS1): Gene resequencing, sequence variation, and functional genomics

Xu, Z. H., Thomae, B. A., Eckloff, B. W., Wieben, E. D. & Weinshilboum, R. M., Jun 1 2003, In : Biochemical Pharmacology. 65, 11, p. 1787-1796 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pharmacogenomics and reducing the frequency of adverse drug events

O'Kane, D. J., Weinshilboum, R. M. & Moyer, T. P., Jan 1 2003, In : Pharmacogenomics. 4, 1, p. 1-4 4 p.

Research output: Contribution to journalEditorial

24 Scopus citations

Richard Weinshilboum: Pharmacogenetics: The future is here!

Weinshilboum, R., May 2003, In : Molecular interventions. 3, 3, p. 118-122 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Thiopurine S-methyltransferase pharmacogenetics: Chaperone protein association and allozyme degradation

Wang, L., Sullivan, W., Toft, D. & Weinshilboum, R., Sep 1 2003, In : Pharmacogenetics. 13, 9, p. 555-564 10 p.

Research output: Contribution to journalArticle

73 Scopus citations
2002

Canine red blood cell thiopurine S-methyltransferase: Companion animal pharmacogenetics

Salavaggione, O. E., Kidd, L., Prondzinski, J. L., Szumlanski, C. L., Pankratz, V. S., Wang, L., Trepanier, L. & Weinshilboum, R. M., Dec 1 2002, In : Pharmacogenetics. 12, 9, p. 713-724 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Catecholestrogen sulfation: Possible role in carcinogenesis

Adjei, A. A. & Weinshilboum, R. M., 2002, In : Biochemical and Biophysical Research Communications. 292, 2, p. 402-408 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: Possible relationship to hypoprothrombinemia

Wood, T. C., Johnson, K. L., Naylor, S. & Weinshilboum, R. M., Oct 1 2002, In : Drug Metabolism and Disposition. 30, 10, p. 1123-1128 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
24 Scopus citations
32 Scopus citations

Human sulfotransferase SULT2A1 pharmacogenetics: Genotype-to-phenotype studies

Thomae, B. A., Eckloff, B. W., Freimuth, R. R., Wieben, E. D. & Weinshilboum, R. M., Sep 17 2002, In : Pharmacogenomics Journal. 2, 1, p. 48-56 9 p.

Research output: Contribution to journalArticle

71 Scopus citations

N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis

Ricart, E., Taylor, W. R., Loftus, E. V., O'Kane, D., Weinshilboum, R. M., Tremaine, W. J., Harmsen, W. S., Zinsmeister, A. R. & Sandborn, W. J., Jan 1 2002, In : American Journal of Gastroenterology. 97, 7, p. 1763-1768 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

The genomic revolution and medicine

Weinshilboum, R. M., Jan 1 2002, In : Mayo Clinic proceedings. 77, 8, p. 745-746 2 p.

Research output: Contribution to journalEditorial

Open Access
16 Scopus citations
1 Scopus citations
2001

2-methoxyestradiol (2-ME2) sulfation: Possible metabolic pathway

Adjei, A. A., Wood, T. C. & Weinshilboum, R. M., Dec 1 2001, In : Clinical pharmacology and therapeutics. 69, 2, p. P75

Research output: Contribution to journalArticle

2 Scopus citations

Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol (MTD) in human tissue

Wood, T. C., Johnson, K. L., Naylor, S. & Weinshilboum, R. M., Dec 1 2001, In : Clinical pharmacology and therapeutics. 69, 2, p. P77

Research output: Contribution to journalArticle

Human 3′-phosphoadenosine 5′-phosphosulfate synthetase: Radiochemical enzymatic assay, biochemical properties, and hepatic variation

Xu, Z. H., Wood, T. C., Adjei, A. A. & Weinshilboum, R. M., 2001, In : Drug Metabolism and Disposition. 29, 2, p. 172-178 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Human sulfotransferase (SULT) 2A1 pharmacogenetics: Genotype to phenotype studies

Thomae, B. A., Eckloff, B., Freimuth, R. R., Carlini, E., Wieben, E. & Weinshilboum, R. M., Dec 1 2001, In : Clinical pharmacology and therapeutics. 69, 2, p. P94

Research output: Contribution to journalArticle

1 Scopus citations

Human sulfotransferase SULT1C1 pharmacogenetics: Gene resequencing and functional genomic studies

Freimuth, R. R., Eckloff, B., Wieben, E. D. & Weinshilboum, R. M., Dec 31 2001, In : Pharmacogenetics. 11, 9, p. 747-756 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide

Lowry, P. W., Franklin, C. L., Weaver, A. L., Szumlanski, C. L., Mays, D. C., Loftus, E. V., Tremaine, W. J., Lipsky, J. J., Weinshilboum, R. M. & Sandborn, W. J., 2001, In : Gut. 49, 5, p. 656-664 9 p.

Research output: Contribution to journalArticle

181 Scopus citations

Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization

Wang, L., Yan, L., McGuire, C., Kozak, C. A., Wang, M., Kim, U. J., Siciliano, M. & Weinshilboum, R. M., Jan 1 2001, In : Inflammation Research. 50, 6, p. 300-308 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
4 Scopus citations

Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects

Carlini, E. J., Raftogianis, R. B., Wood, T. C., Jin, F., Zheng, W., Rebbeck, T. R. & Weinshilboum, R. M., Feb 10 2001, In : Pharmacogenetics. 11, 1, p. 57-68 12 p.

Research output: Contribution to journalArticle

108 Scopus citations
16 Scopus citations

Thiopurine pharmacogenetics: Clinical and molecular studies of thiopurine methyltransferase

Weinshilboum, R., Apr 18 2001, In : Drug Metabolism and Disposition. 29, 4 II, p. 601-605 5 p.

Research output: Contribution to journalArticle

217 Scopus citations
2000

Erratum: Olsalazine and 6-mercaptopurine-related bone marrow suppression: A possible drug-drug interaction (Clinical Pharmacology and Therapeutics (1997) 62 (464-475))

Lewis, L. D., Benin, A., Szumlanski, C. L., Otterness, D. M., Lennard, L., Weinshilboum, R. M. & Nierenberg, D. W., Jan 1 2000, In : Clinical pharmacology and therapeutics. 67, 4, 1 p.

Research output: Contribution to journalComment/debate

Estrogen metabolism by conjugation.

Raftogianis, R., Creveling, C., Weinshilboum, R. & Weisz, J., 2000, In : Journal of the National Cancer Institute. Monographs. 27, p. 113-124 12 p.

Research output: Contribution to journalReview article

Open Access
215 Scopus citations

Histamine N-methyltransferase functional polymorphism: Lack of association with schizophrenia

Yan, L., Szumlanski, C. L., Rice, S. R., Sobell, J. L., Lachman, H. M. & Weinshilboum, R. M., Jun 12 2000, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 96, 3, p. 404-406 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Histamine N-methyltransferase pharmacogenetics: Association of a common functional polymorphism with asthma

Yan, L., Galinsky, R. E., Bernstein, J. A., Liggett, S. B. & Weinshilboum, R. M., Jan 1 2000, In : Pharmacogenetics. 10, 3, p. 261-266 6 p.

Research output: Contribution to journalArticle

76 Scopus citations

Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: Gene cloning, characterization and chromosomal localization

Xu, Z. H., Otterness, D. M., Freimuth, R. R., Carlini, E. J., Wood, T. C., Mitchell, S., Moon, E., Kim, U. J., Xu, J. P., Siciliano, M. J. & Weinshilboum, R. M., Feb 16 2000, In : Biochemical and Biophysical Research Communications. 268, 2, p. 437-444 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization

Freimuth, R. R., Raftogianis, R. B., Wood, T. C., Moon, E., Kim, U. J., Xu, J., Siciliano, M. J. & Weinshilboum, R. M., Apr 15 2000, In : Genomics. 65, 2, p. 157-165 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency

McBride, K. L., Gilchrist, G. S., Smithson, W. A., Weinshilboum, R. M. & Szumlanski, C. L., Jan 1 2000, In : American Journal of Pediatric Hematology/Oncology. 22, 5, p. 441-445 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

The relationship between COMT genotype and the clinical effectiveness of tolcapone, a COMT inhibitor, in patients with Parkinson's disease

Chong, D. J., Suchowersky, O., Szumlanski, C., Weinshilboum, R. M., Brant, R. & Campbell, N. R. C., May 1 2000, In : Clinical Neuropharmacology. 23, 3, p. 143-148 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Thiopurine methyltransferase polymorphic tandem repeat: Genotype-phenotype correlation analysis

Yan, L., Zhang, S., Eiff, B., Szumlanski, C. L., Powers, M., O'Brien, J. F. & Weinshilboum, R. M., Sep 11 2000, In : Clinical pharmacology and therapeutics. 68, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

111 Scopus citations
1999

Balsalazide and azathioprine or 6-mercaptopurine: Evidence for a potentially serious drug interaction [3]

Lowry, P. W., Szumlanski, C. L., Weinshilboum, R. M. & Sandborn, W. J., 1999, In : Gastroenterology. 116, 6, p. 1505-1506 2 p.

Research output: Contribution to journalLetter

70 Scopus citations

Endonuclease-mediated long PCR and its application to restriction mapping.

Her, C. & Weinshilboum, R. M., 1999, In : Current issues in molecular biology. 1, 1-2, p. 77-87 11 p.

Research output: Contribution to journalArticle

Histamine N-methyltransferase (HNMT) pharmacogenetics: Association of the C314T genetic polymorphism with allergic asthma

Yan, L., Galinsky, R. E., Liggett, S. B. & Weinshilboum, R. M., Jan 1 1999, In : Clinical pharmacology and therapeutics. 65, 2, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human 3′-phosphoadenosine 5′-phosphosulfate synthetase (PAPS-S) pharmaco-genetics: Gene cloning and chromosomal localization

Otterness, P. M., Mitchell, S., Moon, E., Kim, U. J. & Weinshilboum, R. M., Jan 1 1999, In : Clinical pharmacology and therapeutics. 65, 2, 1 p.

Research output: Contribution to journalArticle

Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization

Thompson, M. A., Moon, E., Kim, U. J., Xu, J., Siciliano, M. J. & Weinshilboum, R. M., Nov 1 1999, In : Genomics. 61, 3, p. 285-297 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Human indolethylamine N-methyl-transferase (INMT) pharmacogenetics: CDNA and gene cloning and chromosomal localization

Thompson, M. A., Moon, E., Kim, U. J. & Weinshilboum, R. M., Jan 1 1999, In : Clinical pharmacology and therapeutics. 65, 2, 1 p.

Research output: Contribution to journalArticle

Human nicotinamide N-methyltransferase pharmacogenetics: Gene sequence analysis and promoter characterization

Yan, L., Otterness, D. M. & Weinshilboum, R. M., Jan 1 1999, In : Pharmacogenetics. 9, 3, p. 307-316 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Human phenol sulfotransferases SULT1A2 and SULT1A1 Genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations

Raftogianis, R. B., Wood, T. C. & Weinshilboum, R. M., Aug 15 1999, In : Biochemical Pharmacology. 58, 4, p. 605-616 12 p.

Research output: Contribution to journalArticle

150 Scopus citations

Methylation pharmacogenetics: Catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase

Weinshilboum, R. M., Otterness, D. M. & Szumlanski, C. L., May 22 1999, In : Annual Review of Pharmacology and Toxicology. 39, p. 19-52 34 p.

Research output: Contribution to journalReview article

434 Scopus citations

Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: Relation to thiopurine metabolism

Thomsen, J. B., Schrøder, H., Kristinsson, J., Madsen, B., Szumlanski, C., Weinshilboum, R., Andersen, J. B. & Schmiegelow, K., Sep 15 1999, In : Cancer. 86, 6, p. 1080-1086 7 p.

Research output: Contribution to journalArticle

145 Scopus citations