Richard M Weinshilboum, MD

  • 28270 Citations
  • 85 Scopus h-Index
1968 …2020

Research output per year

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Research Output

1987

The therapeutic revolution

Weinshilboum, R. M., Nov 1987, In : Clinical pharmacology and therapeutics. 42, 5, p. 481-484 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

Lennard, L., Van Loon, J. A., Lilleyman, J. S. & Weinshilboum, R. M., Jan 1987, In : Clinical pharmacology and therapeutics. 41, 1, p. 18-25 8 p.

Research output: Contribution to journalArticle

295 Scopus citations
1986

Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population

Boerwinkle, E., Turner, S. T., Weinshilboum, R., Johnson, M., Richelson, E. & Sing, C. F., Jan 1 1986, In : Genetic epidemiology. 3, 5, p. 365-378 14 p.

Research output: Contribution to journalArticle

67 Scopus citations

Human Monoamine Oxidase: Lack of Brain and Platelet Correlation

Young, W. F., Laws, E. R., Sharbrough, F. W. & Weinshilboum, R. M., Jun 1986, In : Archives of General Psychiatry. 43, 6, p. 604-609 6 p.

Research output: Contribution to journalArticle

96 Scopus citations

Mouse liver thiol methyltransferase. Assay conditions, biochemical properties, and strain variation

Otterness, D. M., Keith, R. A., Kerremans, A. L. & Weinshilboum, R. M., 1986, In : Drug Metabolism and Disposition. 14, 6, p. 680-688 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Phenol sulfotransferase in humans: Properties, regulation, and function

Weinshilboum, R. M., Jan 1 1986, In : Federation Proceedings. 45, 8, p. 2223-2228 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

Sulfate conjugation of neurotransmitters and drugs. Introduction

Weinshilboum, R. M., Jan 1 1986, In : Federation Proceedings. 45, 8, p. 2220-2222 3 p.

Research output: Contribution to journalArticle

18 Scopus citations

Thiopurine Methyltransferase: Structure-Activity Relationships for Benzoic Acid Inhibitors and Thiophenol Substrates

Ames, M. M., Selassie, C. D., Woodson, L. C., Van Loon, J. A., Hansch, C. & Weinshilboum, R. M., Jan 1 1986, In : Journal of Medicinal Chemistry. 29, 3, p. 354-358 5 p.

Research output: Contribution to journalArticle

52 Scopus citations
1985

Cephalosporin-induced hypoprothrombinemia: Possible role for thiol methylation of 1-methyltetrazole-5-thiol and 2-methyl-1,3,4-thiadiazole-5-thiol

Kerremans, A. L., Lipsky, J. J., van Loon, J., Gallego, M. O. & Weinshilboum, R. M., Dec 1 1985, In : Journal of Pharmacology and Experimental Therapeutics. 235, 2, p. 382-388 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Human erythrocyte histamine N-methyltransferase: radiochemical microassay and biochemical properties

Van Loon, J. A., Pazmiño, P. A. & Weinshilboum, R. M., Jul 15 1985, In : Clinica Chimica Acta. 149, 2-3, p. 237-251 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Human jejunal phenol sulfotransferase (PST): Partial purification of the 'TL' form

Sundaram, R. & Weinshilboum, R., Jan 1 1985, In : Federation Proceedings. 44, 5, p. No. 8238

Research output: Contribution to journalArticle

5 Scopus citations

Human Phenol Sulfotransferase: Correlation of Brain and Platelet Activities

Young, W. F., Laws, E. R., Sharbrough, F. W. & Weinshilboum, R. M., Apr 1985, In : Journal of neurochemistry. 44, 4, p. 1131-1137 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase

Keith, R. A., Otterness, D. M., Kerremans, A. L. & Weinshilboum, R. M., 1985, In : Drug Metabolism and Disposition. 13, 6, p. 669-676 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Sulfate and methyldopa metabolism: Metabolite patterns and platelet phenol sulfotransferase activity

Campbell, N. R. C., Sundaram, R. S., Werness, P. G., Van Loon, J. & Weinshilboum, R. M., Mar 1985, In : Clinical pharmacology and therapeutics. 37, 3, p. 308-315 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Thiopurine methyltransferase: Mouse kidney and liver assay conditions, biochemical properties and strain variation

Otterness, D. M., Keith, R. A. & Weinshilboum, R. M., 1985, In : Federation Proceedings. 44, 5, p. No. 8229

Research output: Contribution to journalArticle

Thiopurine methyltransferase: mouse kidney and liver assay conditions, biochemical properties and strain variation

Otterness, D. M., Keith, R. A. & Weinshilboum, R. M., Nov 1 1985, In : Biochemical Pharmacology. 34, 21, p. 3823-3830 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
1984
3 Scopus citations
5 Scopus citations

Human Brain Phenol Sulfotransferase: Biochemical Properties and Regional Localization

Young, W. F., Okazaki, H., Laws, E. R. & Weinshilboum, R. M., Sep 1984, In : Journal of neurochemistry. 43, 3, p. 706-715 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Human erythrocyte membrane thiol methyltransferase. S-methylation of captopril, N-acetylcysteine, and 7α-thio-spirolactone

Keith, R. A., Jardine, I., Kerremans, A. & Weinshilboum, R. M., 1984, In : Drug Metabolism and Disposition. 12, 6, p. 717-724 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Human liver phenol sulfotransferase (PST): Partial purification of the 'TS' form

Campbell, N. R. C. & Weinshilboum, R. M., Jan 1 1984, In : Federation Proceedings. 43, 3, p. no. 320

Research output: Contribution to journalArticle

4 Scopus citations

Human pharmacogenetics: Introduction.

Weinshilboum, R. M., May 15 1984, In : Federation Proceedings. 43, 8, p. 2295-2297 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Human pharmacogenetics of methyl conjugation

Weinshilboum, R. M., Jan 1 1984, In : Federation Proceedings. 43, 8, p. 2303-2307 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Human platelet phenol sulfotransferase: Familial variation in thermal stability of the TS form

Van Loon, J. & Weinshilboum, R. M., Dec 1 1984, In : Biochemical Genetics. 22, 11-12, p. 997-1014 18 p.

Research output: Contribution to journalArticle

53 Scopus citations
1 Scopus citations

Immunochemical studies on the evolution of butyrylcholinesterase in higher primates

Mintz, K., Brimijoin, S. & Weinshilboum, R., Jan 1 1984, In : Federation Proceedings. 43, 3, p. no. 1534

Research output: Contribution to journalArticle

Linkage relationships between a major gene for catechol-O-methyltransferase activity and 25 polymorphic marker systems

Wilson, A. F., Elston, R. C., Siervogel, R. M., Weinshilboum, R. & Ward, L. J., Dec 1 1984, In : American journal of medical genetics. 19, 3, p. 525-532 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Major gene model for the inheritance of catechol-o-methyltransferase activity in five large families

Siervogel, R. M., Weinshilboum, R., Wilson, A. F. & Elston, R. C., Jan 1 1984, In : American journal of medical genetics. 19, 2, p. 315-323 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: Correlation with methyldopa metabolism

Campbell, N. R. C., Dunnette, J. H., Mwaluko, G., Van Loon, J. & Weinshilboum, R. M., Jan 1984, In : Clinical pharmacology and therapeutics. 35, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Thiol methyltransferase (TMT) activity in human renal cortex microsomes

Kerremans, A. L., Christensen, H. & Weinshilboum, R. M., Jan 1 1984, In : Federation Proceedings. 43, 3, p. no. 324

Research output: Contribution to journalArticle

2 Scopus citations
1983

Aging and aldosterone

Hegstad, R., Brown, R. D., Jiang, N. S., Kao, P., Weinshilboum, R. M., Strong, C. & Wisgerhof, M., Mar 1983, In : The American Journal of Medicine. 74, 3, p. 442-448 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

Biochemical genetics of cathecholamines in humans

Weinshilboum, R. M., Jan 1 1983, In : Mayo Clinic proceedings. 58, 5, p. 319-330 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Correlation of low and high affinity thiol methyltransferase and phenol methyltransferase activities in human erythrocyte membranes

Keith, R. A., Abraham, R. T., Pazmiño, P. & Weinshilboum, R. M., Jul 15 1983, In : Clinica Chimica Acta. 131, 3, p. 257-272 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

Human kidney thiopurine methyltransferase purification and biochemical properties

Woodson, L. C. & Weinshilboum, R. M., Mar 1 1983, In : Biochemical Pharmacology. 32, 5, p. 819-826 8 p.

Research output: Contribution to journalArticle

118 Scopus citations

Pharmacogenetics of methyl conjugation.

Weinshilboum, R. M., Dec 1 1983, In : Progress in clinical and biological research. 135, p. 167-181 15 p.

Research output: Contribution to journalReview article

6 Scopus citations
3 Scopus citations

Sulphate conjugation of p‐hydroxytriamterene by platelet phenol sulphotransferase: assay conditions and correlation with metabolism in man.

Reiter, C., Werness, PG., Van Loon, J., Smith, LH. & Weinshilboum, RM., Feb 1983, In : British Journal of Clinical Pharmacology. 15, 2, p. 211-220 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Thermolabile and thermostable human platelet phenol sulfotransferase - Substrate specificity and physical separation

Reiter, C., Mwaluko, G., Dunnette, J., Van Loon, J. & Weinshilboum, R., Sep 1 1983, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 324, 2, p. 140-147 8 p.

Research output: Contribution to journalArticle

107 Scopus citations

Thiol methylation pharmacogenetics: Heritability of human erythrocyte thiol methyltransferase activity

Keith, R. A., Loon, J. V., Wussow, L. F. & Weinshilboum, R. M., Oct 1983, In : Clinical pharmacology and therapeutics. 34, 4, p. 521-528 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives

Woodson, L. C., Ames, M. M., Selassie, C. D., Hansch, C. & Weinshilboum, R. M., Dec 1 1983, In : Molecular pharmacology. 24, 3, p. 471-478 8 p.

Research output: Contribution to journalArticle

95 Scopus citations
1982
89 Scopus citations
17 Scopus citations

Family studies of plasma dopamine β-hydroxylase thermal stability

Dunnette, J. & Weinshilboum, R., Jan 1 1982, In : American journal of human genetics. 34, 1, p. 84-99 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Human kidney thiopurine methyltransferase (TPMT): Purification and characterization

Woodson, L. C. & Weinshilboum, R. M., Jan 1 1982, In : Federation Proceedings. 41, 5, p. No. 7062

Research output: Contribution to journalArticle

Human lymphocyte thiopurine methyltransferase pharmacogenetics

Weinshilboum, R. & Van Loon, J., Jan 1 1982, In : Clinical pharmacology and therapeutics. 31, 2, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human platelet phenol sulfotransferase (PST): Substrate specificity of thermolabile and thermostable forms

Reiter, C., Mwaluko, G. & Weinshilboum, R., Jan 1 1982, In : Federation Proceedings. 41, 5, p. No. 7060

Research output: Contribution to journalArticle

3 Scopus citations

Methyldopa and metabolites: Substrates for the thermolabile form of human platelet phenol sulfotransferase

Mwaluko, G. & Weinshilboum, R., Jan 1 1982, In : Clinical pharmacology and therapeutics. 31, 2, p. 252-253 2 p.

Research output: Contribution to journalArticle

Pharmacogenetics of human thiopurine methyltransferase: Kidney-erythrocyte correlation and immunotitration studies

Woodson, L. C., Dunnette, J. H. & Weinshilboum, R. M., Jan 1 1982, In : Journal of Pharmacology and Experimental Therapeutics. 222, 1, p. 174-181 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

Platelet phenol sulfotransferase (PST) activity: Correlation with sulfate conjugation of acetaminophen in man

Reiter, C. & Weinshilboum, R., Jan 1 1982, In : Clinical Research. 30, 4, p. 764A

Research output: Contribution to journalArticle

2 Scopus citations