Biochemistry and Molecular Biology

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2005

Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis

Al Masri, A. & Gendler, S. J., Sep 1 2005, In : Oncogene. 24, 38, p. 5799-5808 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nucleotide dissociation from NBD1 promotes solute transport by MRP1

Yang, R., McBride, A., Hou, Y. X., Goldberg, A. & Chang, X. B., Mar 1 2005, In : Biochimica et Biophysica Acta - Biomembranes. 1668, 2, p. 248-261 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression

Lindsay, T. H., Jonas, B. M., Sevcik, M. A., Kubota, K., Halvorson, K. G., Ghilardi, J. R., Kuskowski, M. A., Stelow, E. B., Mukherjee, P., Gendler, S. J., Wong, G. Y. & Mantyh, P. W., Dec 15 2005, In : Pain. 119, 1-3, p. 233-246 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

REVCOM: A robust Bayesian method for evolutionary rate estimation

Bordner, A. J. & Abagyan, R., May 15 2005, In : Bioinformatics. 21, 10, p. 2315-2321 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of cholesterol in ligand binding and G-protein coupling of serotonin1A receptors solubilized from bovine hippocampus

Chattopadhyay, A., Jafurulla, M., Kalipatnapu, S., Pucadyil, T. J. & Harikumar, K. G., Feb 25 2005, In : Biochemical and Biophysical Research Communications. 327, 4, p. 1036-1041 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Statistical analysis and prediction of protein-protein interfaces

Bordner, A. J. & Abagyan, R., Aug 15 2005, In : Proteins: Structure, Function and Genetics. 60, 3, p. 353-366 14 p.

Research output: Contribution to journalArticle

134 Scopus citations

Targeted measles virus vector displaying echistatin infects endothelial cells via αvβ3 and leads to tumor regression

Hallak, L. K., Merchan, J. R., Storgard, C. M., Loftus, J. C. & Russell, S. J., Jun 15 2005, In : Cancer research. 65, 12, p. 5292-5300 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

The tyrosine kinase Pyk2 promotes migration and invasion of glioma cells

Lipinski, C. A., Tran, N. L., Menashi, E., Rohl, C., Kloss, J., Bay, R. C., Berens, M. E. & Loftus, J. C., May 2005, In : Neoplasia. 7, 5, p. 435-445 11 p.

Research output: Contribution to journalArticle

102 Scopus citations

Tumor-associated carbohydrate antigens: A possible avenue for cancer prevention

Xu, Y., Sette, A., Sidney, J., Gendler, S. J. & Franco, A., Aug 1 2005, In : Immunology and Cell Biology. 83, 4, p. 440-448 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Validation of a mouse adhesion reduction model using Seprafilm®

Morse, A. N., Hammer, R. A., Cornella, J. L. & Loftus, J. C., Dec 2005, In : Journal of Gynecologic Surgery. 21, 4, p. 147-153 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2004

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Young, H. W. J., Molina, J. G., Dimina, D., Zhong, H., Jacobson, M., Chan, L. N. L., Chan, T. S., Lee, J. J. & Blackburn, M. R., Jul 15 2004, In : Journal of Immunology. 173, 2, p. 1380-1389 10 p.

Research output: Contribution to journalArticle

Open Access
111 Scopus citations

Allergen-induced traffic of bone marrow eosinophils, neutrophils and lymphocytes to airways

Johansson, A. K., Sergejeva, S., Sjöstrand, M., Lee, J. J. & Lötvall, J., Nov 1 2004, In : European Journal of Immunology. 34, 11, p. 3135-3145 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer

Basu, G. D., Pathangey, L. B., Tinder, T. L., LaGioia, M., Gendler, S. J. & Mukherjee, P., Nov 1 2004, In : Molecular Cancer Research. 2, 11, p. 632-642 11 p.

Research output: Contribution to journalArticle

130 Scopus citations

Defining a link with asthma in mice congenitally deficient in eosinophils

Lee, J. J., Dimina, D., Macias, M. M. P., Ochkur, S. I., McGarry, M. P., O'Neill, K. R., Protheroe, C., Pero, R., Nguyen, T., Cormier, S. A., Lenkiewicz, E., Colbert, D., Rinaldi, L., Ackerman, S. J., Irvin, C. G. & Lee, N. A., Sep 17 2004, In : Science. 305, 5691, p. 1773-1776 4 p.

Research output: Contribution to journalArticle

555 Scopus citations

Designer Glycopeptides for Cytotoxic T Cell-based Elimination of Carcinomas

Xu, Y., Gendler, S. J. & Franco, A., Mar 1 2004, In : Journal of Experimental Medicine. 199, 5, p. 707-716 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Downregulation of Muc1 in MMTV-c-Neu tumors

Adriance, M. C. & Gendler, S. J., Jan 22 2004, In : Oncogene. 23, 3, p. 697-705 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of raloxifene hydrochloride on endometrial cancer cells in vitro

Hibner, M., Magrina, J. F., Lefler, S. R., Cornella, J. L., Pizarro, A. R. & Loftus, J. C., Jun 1 2004, In : Gynecologic oncology. 93, 3, p. 642-646 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endocytic trafficking routes of wild type and ΔF508 cystic fibrosis transmembrane conductance regulator

Gentzsch, M., Chang, X. B., Cui, L., Wu, Y., Ozols, V. V., Choudhury, A., Pagano, R. E. & Riordan, J. R., Jun 2004, In : Molecular biology of the cell. 15, 6, p. 2684-2696 13 p.

Research output: Contribution to journalArticle

169 Scopus citations

Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen

Clark, K., Simson, L., Newcombe, N., Koskinen, A. M. L., Mattes, J., Lee, N. A., Lee, J. J., Dent, L. A., Matthaei, K. I. & Foster, P. S., Jun 2004, In : Journal of Leukocyte Biology. 75, 6, p. 1001-1009 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Fluorescent modified phosphatidylcholine floppase activity of reconstituted multidrug resistance-associated protein MRP1

Huang, Z., Chang, X., Riordan, J. R. & Huang, Y., Jan 28 2004, In : Biochimica et Biophysica Acta - Biomembranes. 1660, 1-2, p. 155-163 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: Role for tethered mucins as barriers to lumenal infection

Stonebraker, J. R., Wagner, D., Lefensty, R. W., Burns, K., Gendler, S. J., Bergelson, J. M., Boucher, R. C., O'Neal, W. K. & Pickles, R. J., Dec 2004, In : Journal of virology. 78, 24, p. 13755-13768 14 p.

Research output: Contribution to journalArticle

59 Scopus citations

G-protein-dependent cell surface dynamics of the human serotonin 1A receptor tagged to yellow fluorescent protein

Pucadyil, T. J., Kalipatnapu, S., Harikumar, K. G., Rangaraj, N., Karnik, S. S. & Chattopadhyay, A., Dec 21 2004, In : Biochemistry. 43, 50, p. 15852-15862 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Immunoglobulin E and Eosinophil-Dependent Protective Immunity to Larval Onchocerca volvulus in Mice Immunized with Irradiated Larvae

Abraham, D., Leon, O., Schnyder-Candrian, S., Wang, C. C., Galioto, A. M., Kerepesi, L. A., Lee, J. J. & Lustigman, S., Feb 2004, In : Infection and Immunity. 72, 2, p. 810-817 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Immunopathogenesis of Experimental Ulcerative Colitis is Mediated by Eosinophil Peroxidase

Forbes, E., Murase, T., Yang, M., Matthaei, K. I., Lee, J. J., Lee, N. A., Foster, P. S. & Hogan, S. P., May 1 2004, In : Journal of Immunology. 172, 9, p. 5664-5675 12 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/- mice

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Sep 1 2004, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 287, 3 50-3, p. G547-G554

Research output: Contribution to journalArticle

20 Scopus citations

Large-scale prediction of protein geometry and stability changes for arbitrary single point mutations

Bordner, A. J. & Abagyan, R. A., Nov 1 2004, In : Proteins: Structure, Function and Genetics. 57, 2, p. 400-413 14 p.

Research output: Contribution to journalArticle

87 Scopus citations

Ligand binding characteristics of the human serotonin 1A receptor heterologously expressed in CHO cells

Kalipatnapu, S., Pucadyil, T. J., Harikumar, K. G. & Chattopadhyay, A., Apr 1 2004, In : Bioscience reports. 24, 2, p. 101-115 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

Measurement of Intermolecular Distances for the Natural Agonist Peptide Docked at the Cholecystokinin Receptor Expressed in Situ Using Fluorescence Resonance Energy Transfer

Harikumar, K. G., Pinon, D. I., Wessels, W. S., Dawson, E. S., Lybrand, T. P., Prendergast, F. G. & Miller, L. J., Jan 1 2004, In : Molecular pharmacology. 65, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

MUC1 can interact with adenomatous polyposis coli in breast cancer

Hattrup, C. L., Fernandez-Rodriguez, J., Schroeder, J. A., Hansson, G. C. & Gendler, S. J., Apr 2 2004, In : Biochemical and Biophysical Research Communications. 316, 2, p. 364-369 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation

Schroeder, J. A., Al Masri, A., Adriance, M. C., Tessier, J. C., Kotlarczyk, K. L., Thompson, M. C. & Gendler, S. J., Jul 29 2004, In : Oncogene. 23, 34, p. 5739-5747 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: The possible role of TGFβ2

Choudhury, A., Moniaux, N., Ulrich, A. B., Schmied, B. M., Standop, J., Pour, P. M., Gendler, S. J., Hollingsworth, M. A., Aubert, J. P. & Batra, S. K., Feb 9 2004, In : British journal of cancer. 90, 3, p. 657-664 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1

Zhao, Q. & Chang, X. B., Nov 19 2004, In : Journal of Biological Chemistry. 279, 47, p. 48505-48512 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Peroxisome proliferator-activated receptor γ controls Muc1 transcription in trophoblasts

Shalom-Barak, T., Nicholas, J. M., Wang, Y., Zhang, X., Ong, E. S., Young, T. H., Gendler, S. J., Evans, R. M. & Barak, Y., Dec 1 2004, In : Molecular and cellular biology. 24, 24, p. 10661-10669 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient skeletal muscle

Wehling-Henricks, M., Lee, J. J. & Tidball, J. G., Sep 1 2004, In : Neuromuscular Disorders. 14, 8-9, p. 483-490 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer

Pockaj, B. A., Basu, G. D., Pathangey, L. B., Gray, R. J., Hernandez, J. L., Gendler, S. J. & Mukherjee, P., Dec 1 2004, In : Annals of surgical oncology. 11, 3, p. 328-339 12 p.

Research output: Contribution to journalArticle

140 Scopus citations

Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator

Chappe, V., Hinkson, D. A., Howell, L. D., Evagelidis, A., Liao, J., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Jan 1 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 1, p. 390-395 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Mar 1 2004, In : Journal of Lipid Research. 45, 3, p. 438-447 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model

Mukherjee, P., Tinder, T. L., Pathangey, L. B., Chen, L. & Gendler, S. J., Jan 1 2004, In : Breast Disease. 20, p. 53-63 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Verapamil and its derivative trigger apoptosis through glutathione extrusion by multidrug resistance protein MRP1

Trompier, D., Chang, X. B., Barattin, R., Du Moulinet D'Hardemare, A., Di Pietro, A. & Baubichon-Cortay, H., Jul 15 2004, In : Cancer research. 64, 14, p. 4950-4956 7 p.

Research output: Contribution to journalArticle

97 Scopus citations
2003

Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology

Justice, J. P., Borchers, M. T., Crosby, J. R., Hines, E. M., Shen, H. H., Ochkur, S. I., McGarry, M. P., Lee, N. A. & Lee, J. J., Jan 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 1 28-1, p. L169-L178

Research output: Contribution to journalArticle

89 Scopus citations

A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse

Shen, H. H. H., Ochkur, S. I., McGarry, M. P., Crosby, J. R., Hines, E. M., Borchers, M. T., Wang, H., Biechelle, T. L., O'Neill, K. R., Ansay, T. L., Colbert, D. C., Cormier, S. A., Justice, J. P., Lee, N. A. & Lee, J. J., Mar 15 2003, In : Journal of Immunology. 170, 6, p. 3296-3305 10 p.

Research output: Contribution to journalArticle

Open Access
139 Scopus citations

A mutation in the integrin αIIb subunit that selectively inhibits αIIbβ3 receptor function

Perkins, K. B. & Loftus, J. C., Nov 2003, In : Thrombosis and Haemostasis. 90, 5, p. 853-862 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP·Vi trapping at the second domain

Hou, Y. X., Riordan, J. R. & Chang, X. B., Feb 7 2003, In : Journal of Biological Chemistry. 278, 6, p. 3599-3605 7 p.

Research output: Contribution to journalArticle

31 Scopus citations
42 Scopus citations
59 Scopus citations

Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models

Hao, M., Comier, S., Wang, M., Lee, J. J. & Nel, A., Nov 2003, In : Journal of Allergy and Clinical Immunology. 112, 5, p. 905-914 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation

Lipinski, C. A., Tran, N. L., Bay, C., Kloss, J., McDonough, W. S., Beaudry, C., Berens, M. E. & Loftus, J. C., Mar 1 2003, In : Molecular Cancer Research. 1, 5, p. 323-332 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Heterodimerization of Type A and B Cholecystokinin Receptors Enhance Signaling and Promote Cell Growth

Cheng, Z. J., Harikumar, K. G., Holicky, E. L. & Miller, L. J., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52972-52979 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells

Chen, D., Xia, J., Tanaka, Y., Chen, H., Koido, S., Wernet, O., Mukherjee, P., Gendler, S. J., Kufe, D. & Gong, J., Jun 1 2003, In : Immunology. 109, 2, p. 300-307 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione

Manciu, L., Chang, X. B., Buyse, F., Hou, Y. X., Gustot, A., Riordani, J. R. & Ruysschaert, J. M., Jan 31 2003, In : Journal of Biological Chemistry. 278, 5, p. 3347-3356 10 p.

Research output: Contribution to journalArticle

53 Scopus citations