Biochemistry and Molecular Biology

Research Output

2019

Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

Harder, B. G., Peng, S., Sereduk, C. P., Sodoma, A. M., Kitange, G. J., Loftus, J. C., Sarkaria, J. N. & Tran, N. L., Nov 14 2019, In : Molecular Medicine. 25, 1, 49.

Research output: Contribution to journalArticle

Open Access
2018

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

Ding, Z., Roos, A., Kloss, J., Dhruv, H., Peng, S., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Feb 1 2018, In : Molecular Cancer Research. 16, 2, p. 322-332 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

O'Sullivan, J. A., Wei, Y., Carroll, D. J., Moreno-Vinasco, L., Cao, Y., Zhang, F., Lee, J. J., Zhu, Z. & Bochner, B. S., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

9 Scopus citations

EGFRvIII–Stat5 signaling enhances glioblastoma cell migration and survival

Roos, A., Dhruv, H. D., Peng, S., Inge, L. J., Tuncali, S., Pineda, M., Millard, N., Mayo, Z., Eschbacher, J. M., Loftus, J. C., Winkles, J. A. & Tran, N., Jul 1 2018, In : Molecular Cancer Research. 16, 7, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis

Zhang, C., Yi, W., Li, F., Du, X., Wang, H., Wu, P., Peng, C., Luo, M., Hua, W., Wong, C. C. L., Lee, J. J., Li, W., Chen, Z., Ying, S., Ju, Z. & Shen, H., Mar 1 2018, In : Cell Research. 28, 3, p. 323-335 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid

Lin, L., Hwang, B. J., Culton, D. A., Li, N., Burette, S., Koller, B. H., Messingham, K. A., Fairley, J. A., Lee, J. J., Hall, R. P., An, L., Diaz, L. A. & Liu, Z., May 1 2018, In : Journal of Investigative Dermatology. 138, 5, p. 1032-1043 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease

Wright, B., Nguyen, N., Shim, K. P., Masterson, J. C., Jacobsen, E., Ochkur, S. I., Lee, J. J. & Furuta, G. T., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibiting focal adhesion kinase (FAK) blocks IL-4 induced VCAM-1 expression and eosinophil recruitment in vitro and in vivo

Aulakh, G. K., Petri, B., Wojcik, K. M., Colarusso, P., Lee, J. J. & Patel, K. D., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

1 Scopus citations

Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

Patton, J. B., Bonne-Année, S., Deckman, J., Hess, J. A., Torigian, A., Nolan, T. J., Wang, Z., Kliewer, S. A., Durham, A. C., Lee, J. J., Eberhard, M. L., Mangelsdorf, D. J., Lok, J. B. & Abraham, D., Jan 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 1, p. 204-209 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications

Lugogo, N., Francisco, D., Addison, K. J., Manne, A., Pederson, W., Ingram, J. L., Green, C. L., Suratt, B. T., Lee, J. J., Sunday, M. E., Kraft, M. & Ledford, J. G., Mar 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 918-926.e3

Research output: Contribution to journalArticle

5 Scopus citations

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival

Ding, Z., Dhruv, H., Kwiatkowska-Piwowarczyk, A., Ruggieri, R., Kloss, J., Symons, M., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Oct 1 2018, In : Neoplasia (United States). 20, 10, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

Abdala-Valencia, H., Coden, M. E., Chiarella, S. E., Jacobsen, E., Bochner, B. S., Lee, J. J. & Berdnikovs, S., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

22 Scopus citations

Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice

Willetts, L., Felix, L. C., Jacobsen, E., Puttagunta, L., Condjella, R. M., Zellner, K. R., Ochkur, S. I., Kim, J. D., Luo, H., Lee, N. A., Lee, J. J., Moqbel, R. & Lacy, P., Dec 1 2018, In : Communications Biology. 1, 1, 83.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2017

Chemotherapy can induce weight normalization of morbidly obese mice despite undiminished ingestion of high fat diet

Myers, C. E., Hoelzinger, D. B., Truong, T. N., Chew, L. A., Myles, A., Chaudhuri, L., Egan, J. B., Liu, J. D., Gendler, S. J. & Cohen, P. A., 2017, In : Oncotarget. 8, 3, p. 5426-5438 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1

Elgilani, F., Mao, S. A., Glorioso, J. M., Yin, M., Iankov, I. D., Singh, A., Amiot, B., Rinaldo, P., Marler, R. J., Ehman, R. L., Grompe, M., Lillegard, J. B., Hickey, R. & Nyberg, S., Jan 1 2017, In : American Journal of Pathology. 187, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Coexpressed class B G protein-coupled secretin and GLP-1 receptors self-and cross-associate: Impact on pancreatic islets

Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., Jun 1 2017, In : Endocrinology. 158, 6, p. 1685-1700 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

CRISPR/Cas9-Mediated Three Nucleotide Insertion Corrects a Deletion Mutation in MRP1/ABCC1 and Restores Its Proper Folding and Function

Xu, Q., Hou, Y. X. & Chang, X-B. D., Jun 1 2017, In : Molecular Therapy - Nucleic Acids. 7, p. 429-438 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

Yan, Y., Xu, T. H., Harikumar, K. G., Miller, L. J., Melcher, K. & Xu, H. E., Sep 22 2017, In : Journal of Biological Chemistry. 292, 38, p. 15826-15837 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

Uderhardt, S., Ackermann, J. A., Fillep, T., Hammond, V. J., Willeit, J., Santer, P., Mayr, M., Biburger, M., Miller, M., Zellner, K. R., Stark, K., Zarbock, A., Rossaint, J., Schubert, I., Mielenz, D., Dietel, B., Raaz-Schrauder, D., Ay, C., Gremmel, T., Thaler, J. & 14 others, Heim, C., Herrmann, M., Collins, P. W., Schabbauer, G., Mackman, N., Voehringer, D., Nadler, J. L., Lee, J. J., Massberg, S., Rauh, M., Kiechl, S., Schett, G., O'Donnell, V. B. & Krönke, G., Jul 1 2017, In : Journal of Experimental Medicine. 214, 7, p. 2121-2138 18 p.

Research output: Contribution to journalArticle

25 Scopus citations

Eosinophils promote antiviral immunity in mice infected with influenza A virus

Samarasinghe, A. E., Melo, R. C. N., Duan, S., Le Messurier, K. S., Liedmann, S., Surman, S. L., Lee, J. J., Hurwitz, J. L., Thomas, P. G. & McCullers, J. A., Apr 15 2017, In : Journal of Immunology. 198, 8, p. 3214-3226 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Frontline science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation

Ochkur, S. I., Doyle, A. D., Jacobsen, E., LeSuer, W. E., Li, W., Protheroe, C. A., Zellner, K. R., Colbert, D., Shen, H. H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., Sep 1 2017, In : Journal of Leukocyte Biology. 102, 3, p. 589-599 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells

Roos, A., Dhruv, H. D., Mathews, I. T., Inge, L. J., Tuncali, S., Hartman, L. K., Chow, D., Millard, N., Yin, H. H., Kloss, J., Loftus, J. C., Winkles, J. A., Berens, M. E. & Tran, N., 2017, In : Oncotarget. 8, 7, p. 12234-12246 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Lung pathologies in a chronic inflammation mouse model are independent of eosinophil degranulation

Jacobsen, E., Ochkur, S. I., Doyle, A. D., LeSuer, W. E., Li, W., Protheroe, C. A., Colbert, D., Zellner, K. R., Shen, H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., May 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1321-1332 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular and microenvironmental determinants of glioma stem-like cell survival and invasion

Roos, A., Ding, Z., Loftus, J. C. & Tran, N., Jun 16 2017, In : Frontiers in Oncology. 7, JUN, 120.

Research output: Contribution to journalReview article

40 Scopus citations

Mouse monoclonal antibodies generated from full length human cereblon: Detection of cereblon protein in patients with multiple myeloma

Chang, X-B. D., Xu, Q., Hou, Y., Li, C., Xu, Y. & Stewart, A. K., Sep 17 2017, In : International Journal of Molecular Sciences. 18, 9, 1999.

Research output: Contribution to journalArticle

3 Scopus citations

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Baxter, L. C., Gaw, N., Ranjbar, S., Plasencia, J., Dueck, A., Peng, S., Smith, K. A., Nakaji, P., Karis, J. P., Quarles, C. C., Wu, T., Loftus, J. C., Jenkins, R. B., Sicotte, H., Kollmeyer, T. M., O'Neill, B. P., Elmquist, W. & 7 others, Hoxworth, J. M., Frakes, D., Sarkaria, J. N., Swanson, K., Tran, N., Li, J. & Mitchell, J. R., 2017, In : Neuro-Oncology. 19, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

60 Scopus citations

SiglecF+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice

Percopo, C. M., Brenner, T. A., Ma, M., Kraemer, L. S., Hakeem, R. M. A., Lee, J. J. & Rosenberg, H. F., Jan 1 2017, In : Journal of Leukocyte Biology. 101, 1, p. 321-328 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Skeletal and uterotrophic effects of endoxifen in female rats

Gingery, A., Iwaniec, U. T., Subramaniam, M., Turner, R. T., Pitel, K. S., McGovern, R. M., Reid, J. M., Marler, R. J., Ingle, J. N., Goetz, M. P. & Hawse, J. R., Oct 1 2017, In : Endocrinology. 158, 10, p. 3354-3368 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

Ward, R. J., Pediani, J. D., Harikumar, K. G., Miller, L. J. & Milligan, G., Jun 1 2017, In : Biochemical Journal. 474, 11, p. 1879-1895 17 p.

Research output: Contribution to journalArticle

12 Scopus citations

Sputum autoantibodies in patients with severe eosinophilic asthma

Mukherjee, M., Bulir, D. C., Radford, K., Kjarsgaard, M., Huang, C. M., Jacobsen, E., Ochkur, S. I., Catuneanu, A., Lamothe-Kipnes, H., Mahony, J., Lee, J. J., Lacy, P. & Nair, P. K., Jan 1 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

20 Scopus citations

Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens

Pathangey, L. B., McCurry, D. B., Gendler, S. J., Dominguez, A. L., Gorman, J. E., Pathangey, G., Mihalik, L. A., Dang, Y., Disis, M. L. & Cohen, P. A., 2017, In : Oncotarget. 8, 7, p. 10785-10808 24 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis and Immunological Evaluation of a Multicomponent Cancer Vaccine Candidate Containing a Long MUC1 Glycopeptide

Supekar, N. T., Lakshminarayanan, V., Capicciotti, C. J., Sirohiwal, A., Madsen, C. S., Wolfert, M. A., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 1 2017, (Accepted/In press) In : ChemBioChem.

Research output: Contribution to journalArticle

2 Scopus citations

Throat-derived eosinophil peroxidase is not a reliable biomarker of pediatric eosinophilic esophagitis

Schroeder, S., Ochkur, S. I., Shim, K. P., Galvin, K. M., Bauer, C. S., Lee, J. J. & Wright, B., Nov 1 2017, In : Journal of Allergy and Clinical Immunology: In Practice. 5, 6, p. 1804-1805 2 p.

Research output: Contribution to journalLetter

3 Scopus citations

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

DeBruine, Z. J., Ke, J., Harikumar, K. G., Gu, X., Borowsky, P., Williams, B. O., Xu, W., Miller, L. J., Xu, H. E. & Melcher, K., 2017, In : Genes and Development. 31, 9, p. 916-926 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2016

Aberrant glycosylation of anchor-optimized MUC1 peptides can enhance antigen binding affinity and reverse tolerance to cytotoxic T lymphocytes

Pathangey, L. B., Lakshminarayanan, V., Suman, V. J., Pockaj, B. A., Mukherjee, P. & Gendler, S. J., Sep 1 2016, In : Biomolecules. 6, 3, 31.

Research output: Contribution to journalArticle

4 Scopus citations

A flow cytometry-based assay for procoagulant platelet polyphosphate

Labberton, L., Long, A. T., Gendler, S. J., Snozek, C. L., Stavrou, E. X., Nickel, K. F., Maas, C., Blankenberg, S., Hernandez, J. S. & Renné, T., 2016, (Accepted/In press) In : Cytometry Part B - Clinical Cytometry.

Research output: Contribution to journalArticle

8 Scopus citations

Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1

Hickey, R., Mao, S. A., Glorioso, J., Elgilani, F., Amiot, B., Chen, H., Rinaldo, P., Marler, R. J., Jiang, H., DeGrado, T. R., Suksanpaisan, L., O'Connor, M. K., Freeman, B. L., Ibrahim, S. C., Peng, K-W., Harding, C. O., Ho, C. S., Grompe, M., Ikeda, Y. H., Lillegard, J. B. & 2 others, Russell, S. J. & Nyberg, S., Jul 27 2016, In : Science Translational Medicine. 8, 349, 349ra99.

Research output: Contribution to journalArticle

22 Scopus citations

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Tolllike receptor agonists

Manrique, S. Z., Dominguez, A. L., Mirza, N., Spencer, C. D., Bradley, J. M., Finke, J. H., Lee, J. J., Pease, L. R., Gendler, S. J. & Cohen, P. A., 2016, In : Oncotarget. 7, 28, p. 42919-42942 24 p.

Research output: Contribution to journalArticle

12 Scopus citations

Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2

Xia, L. X., Hua, W., Jin, Y., Tian, B. P., Qiu, Z. W., Zhang, C., Che, L. Q., Zhou, H. B., Wu, Y. F., Huang, H. Q., Lan, F., Ke, Y. H., Lee, J. J., Li, W., Ying, S. M., Chen, Z. H. & Shen, H. H., Apr 7 2016, In : Cell Death and Disease. 7, e2175.

Research output: Contribution to journalArticle

11 Scopus citations

Eosinophil peroxidase catalyzed protein carbamylation participates in asthma

Wang, Z., DiDonato, J. A., Buffa, J., Comhair, S. A., Aronica, M. A., Dweik, R. A., Lee, N. A., Lee, J. J., Thomassen, M. J., Kavuru, M., Erzurum, S. C. & Hazen, S. L., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 22118-22135 18 p.

Research output: Contribution to journalArticle

13 Scopus citations

EUS-guided portal injection chemotherapy for treatment of hepatic metastases: Feasibility in the acute porcine model

Faigel, D. O., Lake, D. F., Landreth, T. L., Kelman, C. C. & Marler, R. J., Feb 1 2016, In : Gastrointestinal Endoscopy. 83, 2, p. 444-446 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

Xu, Q., Hou, Y. X., Langlais, P. R., Erickson, P., Zhu, J., Shi, C. X., Luo, M., Zhu, Y., Xu, Y., Mandarino, L. J., Stewart, A. K. & Chang, X-B. D., May 3 2016, In : BMC Cancer. 16, 1, 297.

Research output: Contribution to journalArticle

19 Scopus citations

Human and mouse eosinophils have antiviral activity against parainfluenza virus

Drake, M. G., Bivins-Smith, E. R., Proskocil, B. J., Nie, Z., Scott, G. D., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., Sep 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 3, p. 387-394 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

IL-33 drives eosinophil infiltration and pathogenic type 2 helper T-cell immune responses leading to chronic experimental ileitis

De Salvo, C., Wang, X. M., Pastorelli, L., Mattioli, B., Omenetti, S., Buela, K. A., Chowdhry, S., Garg, R. R., Goodman, W. A., Rodriguez-Palacios, A., Smith, D. E., Abbott, D. W., Cominelli, F., Bamias, G., Xin, W., Lee, J. J., Vecchi, M. & Pizarro, T. T., Apr 1 2016, In : American Journal of Pathology. 186, 4, p. 885-898 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Induction of airway allergic inflammation by hypothiocyanite via epithelial cells

Suzuki, S., Ogawa, M., Ohta, S., Nunomura, S., Nanri, Y., Shiraishi, H., Mitamura, Y., Yoshihara, T., Lee, J. J. & Izuhara, K., Dec 30 2016, In : Journal of Biological Chemistry. 291, 53, p. 27219-27227 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury

Al-Bataineh, M. M., Kinlough, C. L., Poland, P. A., Pastor-Soler, N. M., Sutton, T. A., Mang, H. E., Bastacky, S. I., Gendler, S. J., Madsen, C. S., Singh, S., Monga, S. P. & Hughey, R. P., Mar 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 6, p. F569-F579

Research output: Contribution to journalArticle

15 Scopus citations

MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice

Lakshminarayanan, V., Supekar, N. T., Wei, J., McCurry, D. B., Dueck, A., Kosiorek, H. E., Trivedi, P. P., Bradley, J. M., Madsen, C. S., Pathangey, L. B., Hoelzinger, D. B., Wolfert, M. A., Boons, G. J., Cohen, P. A. & Gendler, S. J., Jan 1 2016, In : PLoS One. 11, 1, e0145920.

Research output: Contribution to journalArticle

20 Scopus citations

Potential sites of CFTR activation by tyrosine kinases

Billet, A., Jia, Y., Jensen, T. J., Hou, Y. X., Chang, X-B. D., Riordan, J. R. & Hanrahan, J. W., 2016, In : Channels (Austin, Tex.). 10, 3, p. 247-251 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway

Dhruv, H. D., Roos, A., Tomboc, P. J., Tuncali, S., Chavez, A., Mathews, I., Berens, M. E., Loftus, J. C. & Tran, N., Feb 1 2016, In : Journal of Neuro-Oncology. 126, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

SGEF is regulated via TWEAK/Fn14/NF-κB signaling and promotes survival by modulation of the DNA repair response to temozolomide

Fortin Ensign, S. P., Roos, A., Mathews, I. T., Dhruv, H. D., Tuncali, S., Sarkaria, J. N., Symons, M. H., Loftus, J. C., Berens, M. E. & Tran, N., Mar 1 2016, In : Molecular Cancer Research. 14, 3, p. 302-312 11 p.

Research output: Contribution to journalArticle

9 Scopus citations