Biochemistry and Molecular Biology

Research Output 1993 2019

1999
173 Citations (Scopus)

The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration

Cieslewicz, G., Tomkinson, A., Adler, A., Duez, C., Schwarze, J., Takeda, K., Larson, K. A., Lee, J. J., Irvin, C. G. & Gelfand, E. W., Aug 1999, In : Journal of Clinical Investigation. 104, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

Interleukin-5
Eosinophils
Cromolyn Sodium
Ovalbumin
Lung
5 Citations (Scopus)

The macroimportance of the pulmonary immune microenvironment

Lee, N. A. & Lee, J. J., 1999, In : American Journal of Respiratory Cell and Molecular Biology. 21, 3, p. 298-302 5 p.

Research output: Contribution to journalArticle

Immunization
Animals
Cytokines
Antigens
1998
292 Citations (Scopus)

Abnormal heart rate regulation in GIRK4 knockout mice

Wickman, K., Nemec, J., Gendler, S. J. & Clapham, D. E., Jan 1998, In : Neuron. 20, 1, p. 103-114 12 p.

Research output: Contribution to journalArticle

Knockout Mice
Heart Rate
Telemetry
Vagus Nerve
Potassium Channels
10 Citations (Scopus)

A microsatellite within the MUC1 locus at 1q21 is altered in the neoplastic cells of breast cancer patients

Waltz, M. R., Pandelidis, S. M., Pratt, W., Barnes, D., Swallow, D. M., Gendler, S. J. & Cohen, E. P., Jan 1 1998, In : Cancer Genetics and Cytogenetics. 100, 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Breast Neoplasms
varespladib methyl
BRCA1 Gene
Minisatellite Repeats
56 Citations (Scopus)

CD4+ lymphocytes provide MUC1-specific tumor immunity in vivo that is undetectable in vitro and is absent in MUC1 transgenic mice

Tempero, R. M., VanLith, M. L., Morikane, K., Rowse, G. J., Gendler, S. J. & Hollingsworth, M. A., Nov 15 1998, In : Journal of Immunology. 161, 10, p. 5500-5506 7 p.

Research output: Contribution to journalArticle

Transgenic Mice
Immunity
Lymphocytes
Neoplasms
Adoptive Transfer
64 Citations (Scopus)

Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucus

Parmley, R. R. & Gendler, S. J., Nov 15 1998, In : Journal of Clinical Investigation. 102, 10, p. 1798-1806 9 p.

Research output: Contribution to journalArticle

Mucus
Cystic Fibrosis
Mucins
RNA
Gastrointestinal Tract
57 Citations (Scopus)

Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel

Mathews, C. J., Tabcharani, J. A., Chang, X-B. D., Jensen, T. J., Riordan, J. R. & Hanrahan, J. W., Apr 15 1998, In : Journal of Physiology. 508, 2, p. 365-377 13 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Chloride Channels
Cyclic AMP-Dependent Protein Kinases
Adenylyl Imidodiphosphate
Nucleotides

Eosinophilic Polymyositis in a Mouse

Krugner-Higby, L. A., Gendron, A., Garland, T., Carter, P. A., Swallow, J. G. & Lee, J. J., 1998, In : Contemporary Topics in Laboratory Animal Science. 37, 6, p. 94-97 4 p.

Research output: Contribution to journalArticle

polymyositis
Polymyositis
lesions (animal)
mice
back (body region)
21 Citations (Scopus)

Estrogen receptor does not directly regulate the murine Muc-1 promoter

Zhou, X., DeSouza, M. M., Julian, J., Gendler, S. J. & Carson, D. D., Aug 25 1998, In : Molecular and Cellular Endocrinology. 143, 1-2, p. 65-78 14 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Response Elements
Genes
Estrogens
Epithelial Cells
46 Citations (Scopus)

Genetic modulation of neu proto-oncogene-induced mammary tumorigenesis

Rowse, G. J., Ritland, S. R. & Gendler, S. J., Jun 15 1998, In : Cancer Research. 58, 12, p. 2675-2679 5 p.

Research output: Contribution to journalArticle

Proto-Oncogenes
Carcinogenesis
Breast
Neoplasms
Mouse mammary tumor virus

In vitro kinetic analysis of cellular anti-MUC1 immune responses in MUC1 transgenic mice

VanLith, M. L., Tempero, R. M., Gendler, S. J. & Hollingsworth, M. A., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Transgenic Mice
Tumors
immune response
genetically modified organisms
kinetics
5 Citations (Scopus)

Mimic 1 of MUC1

Finn, O. J. & Gendler, S. J., 1998, In : Nature Biotechnology. 16, 3, p. 236-237 2 p.

Research output: Contribution to journalArticle

Mice (computer peripherals)
Epitopes
Neoplasm Antigens
Mucins
Peptides
15 Citations (Scopus)

Mouse Mucin 1 (MUC1) defined by monoclonal antibodies

Xing, P. X., Lees, C., Lodding, J., Prenzoska, J., Poulos, G., Sandrin, M., Gendler, S. J. & Mckenzie, I. F. C., Jun 10 1998, In : International Journal of Cancer. 76, 6, p. 875-883 9 p.

Research output: Contribution to journalArticle

Mucin-1
Monoclonal Antibodies
Mucins
Antibodies
Lymphocytes
281 Citations (Scopus)

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

Loo, M. A., Jensen, T. J., Cui, L., Hou, Y. X., Chang, X-B. D. & Riordan, J. R., Dec 1 1998, In : EMBO Journal. 17, 23, p. 6879-6887 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Endoplasmic Reticulum
Degradation
Calnexin
Association reactions
2 Citations (Scopus)

Recovery of an oligonucleotide using silver ions immobilized onto paramagnetic particles

Ramírez-Vick, J. E., Garcia, A. A. & Lee, J., Aug 1998, In : Preparative Biochemistry and Biotechnology. 28, 3, p. 243-260 18 p.

Research output: Contribution to journalArticle

Fluorescein
Silver
Oligonucleotides
Ions
Recovery
213 Citations (Scopus)

Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells

Gong, J., Chen, D., Kashiwaba, M., Li, Y., Chen, L., Takeuchi, H., Ou, H., Rowse, G. J., Gendler, S. J. & Kufe, D., May 26 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 11, p. 6279-6283 5 p.

Research output: Contribution to journalArticle

Dendritic Cells
Transgenic Mice
Immunization
Carcinoma
Antigens
35 Citations (Scopus)

Stimulation of ATPase activity of purified multidrug resistance- associated protein by nucleoside diphosphates

Chang, X-B. D., Hou, Y. X. & Riordan, J. R., Sep 11 1998, In : Journal of Biological Chemistry. 273, 37, p. 23844-23848 5 p.

Research output: Contribution to journalArticle

Multidrug Resistance-Associated Proteins
Diphosphates
Nucleosides
Adenosine Triphosphatases
Hydrolysis
81 Citations (Scopus)

The biological role of mucins in cellular interactions and immune regulation: Prospects for cancer immunotherapy

Agrawal, B., Gendler, S. J. & Longenecker, B. M., Sep 1 1998, In : Molecular Medicine Today. 4, 9, p. 397-403 7 p.

Research output: Contribution to journalArticle

Mucins
Immunotherapy
T-Lymphocytes
Neoplasms
Cytotoxic T-Lymphocytes

Tolerance and immunity to MUC1 in a human MUC1 transgenic murine model

Tempero, R. M., Morikane, K., Vanlith, M. L., Gendler, S. J. & Hollingsworth, M. A., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Tumors
Immunity
immunity
animal models
genetically modified organisms
168 Citations (Scopus)

Tolerance and immunity to MUC1 in a human MUC1 transgenic murine model

Rowse, G. J., Tempero, R. M., VanLith, M. L., Hollingsworth, M. A. & Gendler, S. J., Jan 15 1998, In : Cancer Research. 58, 2, p. 315-321 7 p.

Research output: Contribution to journalArticle

Transgenic Mice
Immunity
Neoplasms
Immunotherapy
Immunoglobulin Class Switching
150 Citations (Scopus)

β Integrins participate in the hypertrophic response of rat ventricular myocytes

Ross, R. S., Pham, C., Shai, S. Y., Goldhaber, J. I., Fenczik, C., Glembotski, C. C., Ginsberg, M. H. & Loftus, J. C., Jun 15 1998, In : Circulation Research. 82, 11, p. 1160-1172 13 p.

Research output: Contribution to journalArticle

Integrins
Muscle Cells
Atrial Natriuretic Factor
Atrial Myosins
Extracellular Matrix Proteins
1997
Mucins
Genes
Mucus
Cysteine
Membranes
15 Citations (Scopus)

Asthma: Does IL-5 Have a More Provocative Role?

Lee, N. A. & Lee, J. J., 1997, In : American Journal of Respiratory Cell and Molecular Biology. 16, 5, p. 497-500 4 p.

Research output: Contribution to journalArticle

Animal Disease Models
Interleukin-5
Ovalbumin
Bronchi
Eosinophils
128 Citations (Scopus)

ATPase activity of purified multidrug resistance-associated protein

Chang, X-B. D., Hou, Y. X. & Riordan, J. R., Dec 5 1997, In : Journal of Biological Chemistry. 272, 49, p. 30962-30968 7 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Multidrug Resistance-Associated Proteins
Adenosine Triphosphatases
Purification
Membranes
177 Citations (Scopus)

Expression of IL-5 in Thymocytes/T Cells Leads to the Development of a Massive Eosinophilia, Extramedullary Eosinophilopoiesis, and Unique Histopathologies

Lee, N. A., McGarry, M. P., Larson, K. A., Horton, M. A., Kristensen, A. B. & Lee, J. J., Feb 1 1997, In : Journal of Immunology. 158, 3, p. 1332-1344 13 p.

Research output: Contribution to journalArticle

Interleukin-5
Eosinophilia
Thymocytes
T-Lymphocytes
Eosinophils
63 Citations (Scopus)

Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy

Croy, B. A., Ashkar, A. A., Foster, R. A., DiSanto, J. P., Magram, J., Carson, D., Gendler, S. J., Grusby, M. J., Wagner, N., Muller, W. & Guimond, M. J., Nov 15 1997, In : Journal of Reproductive Immunology. 35, 2, p. 111-133 23 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Uterus
Pregnancy
Genes
Decidua
439 Citations (Scopus)

Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D. & Lee, N. A., Jun 16 1997, In : Journal of Experimental Medicine. 185, 12, p. 2143-2156 14 p.

Research output: Contribution to journalArticle

Interleukin-5
Eosinophils
Transgenic Mice
Focal Epithelial Hyperplasia
Asthma
40 Citations (Scopus)

Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice

Ritland, S. R., Rowse, G. J., Chang, Y. & Gendler, S. J., Aug 15 1997, In : Cancer Research. 57, 16, p. 3520-3525 6 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Transgenic Mice
Breast Neoplasms
Neoplasm Metastasis
Lung
102 Citations (Scopus)

New insights into integrin-ligand interaction

Loftus, J. C. & Liddington, R. C., May 15 1997, In : Journal of Clinical Investigation. 99, 10, p. 2302-2306 5 p.

Research output: Contribution to journalArticle

Allosteric Regulation
Macromolecular Substances
Biological Models
Structural Models
Cell Adhesion Molecules
29 Citations (Scopus)

New insights into integrin-ligand interaction

Loftus, J. C. & Liddington, R. C., 1997, In : Journal of Clinical Investigation. 100, 11 SUPPL.

Research output: Contribution to journalArticle

Biological Models
Protein Conformation
Vascular Endothelium
Molecular Structure
Tertiary Protein Structure
18 Citations (Scopus)

Partial structure, chromosome localization, and expression of the mouse Girk4 gene

Wickman, K., Seldin, M. F., Gendler, S. J. & Clapham, D. E., Mar 15 1997, In : Genomics. 40, 3, p. 395-401 7 p.

Research output: Contribution to journalArticle

Chromosome Structures
Genes
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 9
Messenger RNA
5 Citations (Scopus)

Partial structure, chromosome localization, and expression of the mouse Icln gene

Wickman, K., Seldin, M. F., James, M. R., Gendler, S. J. & Clapham, D. E., Mar 15 1997, In : Genomics. 40, 3, p. 402-408 7 p.

Research output: Contribution to journalArticle

Chromosome Structures
Chloride Channels
Genes
Pseudogenes
Chromosomes, Human, Pair 7
155 Citations (Scopus)

Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions

Linsdell, P., Tabcharani, J. A., Rommens, J. M., Hou, Y. X., Chang, X-B. D., Tsui, L. C., Riordan, J. R. & Hanrahan, J. W., Oct 1997, In : Journal of General Physiology. 110, 4, p. 355-364 10 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Chloride Channels
Anions
Permeability
formic acid
716 Citations (Scopus)

The mouse Fused locus encodes axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M. & Costantini, F., Jul 11 1997, In : Cell. 90, 1, p. 181-192 12 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
GTP-Binding Protein Regulators
Messenger RNA
Embryonic Structures
RGS Proteins
2 Citations (Scopus)

The murine eosinophil major basic protein gene (Prg2) maps to Chromosome 2

Denzler, K. L., Levin, W. J., Quiram, P. A., Lee, N. A. & Lee, J. J., May 1997, In : Mammalian Genome. 8, 5, p. 382-383 2 p.

Research output: Contribution to journalArticle

Eosinophil Granule Proteins
Eosinophil Major Basic Protein
Muridae
Genetic Crosses
Chromosomes, Human, Pair 2
8 Citations (Scopus)

The murine eosinophil peroxidase gene (Epx) maps to Chromosome 11

Denzler, K. L., Levin, W. J., Lee, J. J. & Lee, N. A., May 1997, In : Mammalian Genome. 8, 5, p. 381-382 2 p.

Research output: Contribution to journalArticle

Eosinophil Peroxidase
Muridae
Genetic Crosses
Species Specificity
Peroxidases
61 Citations (Scopus)

The single MyoD family gene of Ciona intestinalis encodes two differentially expressed proteins: Implications for the evolution of chordate muscle gene regulation

Meedel, T. H., Farmer, S. C. & Lee, J. J., May 1997, In : Development. 124, 9, p. 1711-1721 11 p.

Research output: Contribution to journalArticle

MyoD Protein
Ciona intestinalis
Chordata
Urochordata
Muscles
1996
44 Citations (Scopus)

cAMP- and Ca2+-independent activation of cystic fibrosis transmembrane conductance regulator channels by phenylimidazothiazole drugs

Becq, F., Verrier, B., Chang, X-B. D., Riordan, J. R. & Hanrahan, J. W., 1996, In : Journal of Biological Chemistry. 271, 27, p. 16171-16179 9 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Chemical activation
Levamisole
Cyclic AMP-Dependent Protein Kinases
Pharmaceutical Preparations
2 Citations (Scopus)

Chromosomal mapping of three mucin genes in the rat

Klinga-Levan, K., Gum, J. R., Gendler, S. J., Kim, Y. & Hansson, G. C., 1996, In : Mammalian Genome. 7, 3, p. 248-250 3 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Cloning of the murine eosinophil peroxidase gene (mEPO): Characterization of a conserved subgroup of mammalian hematopoietic peroxidases

Horton, M. A., Larson, K. A., Lee, J. J. & Lee, N. A., Aug 1996, In : Journal of Leukocyte Biology. 60, 2, p. 285-294 10 p.

Research output: Contribution to journalArticle

Eosinophil Peroxidase
Peroxidases
Organism Cloning
Genes
Eosinophil Granule Proteins
22 Citations (Scopus)

Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2 mucin

Karlsson, N. G., Johansson, M. E., Asker, N., Karlsson, H., Gendler, S. J., Carlstedt, I. & Hansson, G. C., 1996, In : Glycoconjugate Journal. 13, 5, p. 823-831 9 p.

Research output: Contribution to journalArticle

Glycopeptides
Mucins
Rats
Oligosaccharides
Small Intestine
25 Citations (Scopus)

Regulation of the CFTR chloride channel from humans and sharks

Hanrahan, J. W., Mathews, C. J., Grygorczyk, R., Tabcharani, J. A., Grzelczak, Z., Chang, X-B. D. & Riordan, J. R., Jul 1 1996, In : Journal of Experimental Zoology. 275, 4, p. 283-291 9 p.

Research output: Contribution to journalArticle

chloride channels
cystic fibrosis
sharks
phosphorylation
hydrolysis
45 Citations (Scopus)

Synthesis and intracellular trafficking of Muc-1 and mucins by polarized mouse uterine epithelial cells

Pimental, R. A., Julian, J., Gendler, S. J. & Carson, D. D., 1996, In : Journal of Biological Chemistry. 271, 45, p. 28128-28137 10 p.

Research output: Contribution to journalArticle

Mucin-1
Mucins
Epithelial Cells
Golgi Apparatus
Endocrinology
53 Citations (Scopus)

The epithelial mucin MUC1 contains at least two discrete signals specifying membrane localization in cells

Pemberton, L. F., Rughetti, A., Taylor-Papadimitriou, J. & Gendler, S. J., Jan 26 1996, In : Journal of Biological Chemistry. 271, 4, p. 2332-2340 9 p.

Research output: Contribution to journalArticle

Mucins
Membranes
Mucin-1
Mutant Proteins
Fusion reactions
3 Citations (Scopus)

Thymocyte Cell Fate Alteration by High Levels of CD8α Is Independent of CD8-lck Association

Smith, D. H., Lee, N. A. & Lacy, E., Aug 1 1996, In : Journal of Immunology. 157, 3, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

Thymocytes
Protein-Tyrosine Kinases
Transgenic Mice
T-Lymphocytes
Peptides
65 Citations (Scopus)

Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily

Larson, K. A., Olson, E. V., Madden, B. J., Gleich, G. J., Lee, N. A. & Lee, J. J., Oct 29 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 22, p. 12370-12375 6 p.

Research output: Contribution to journalArticle

Ribonucleases
Eosinophils
Primates
Eosinophil Cationic Protein
Genes
1995
57 Citations (Scopus)

Analysis of mammalian MUC1 genes reveals potential functionally important domains

Spicer, A. P., Duhig, T., Chilton, B. S. & Gendler, S. J., Dec 1995, In : Mammalian Genome. 6, 12, p. 885-888 4 p.

Research output: Contribution to journalArticle

Nucleic Acid Sequence Homology
Molecular Sequence Data
Hylobates
Amino Acid Sequence Homology
Mucin-1
70 Citations (Scopus)

cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation

Seibert, F. S., Tabcharani, J. A., Chang, X-B. D., Dulhanty, A. M., Mathews, C., Hanrahan, J. W. & Riordan, J. R., 1995, In : Journal of Biological Chemistry. 270, 5, p. 2158-2162 5 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Chemical activation
Protein Kinases
209 Citations (Scopus)

Delayed mammary tumor progression in Muc-1 null mice

Spicer, A. P., Rowse, G. J., Lidner, T. K. & Gendler, S. J., Dec 15 1995, In : Journal of Biological Chemistry. 270, 50, p. 30093-30101 9 p.

Research output: Contribution to journalArticle

Tumors
Breast Neoplasms
Viral Tumor Antigens
Membrane Glycoproteins
Mucins
804 Citations (Scopus)

Epithelial mucin genes

Gendler, S. J. & Spicer, A. P., 1995, In : Annual Review of Physiology. 57, p. 607-634 28 p.

Research output: Contribution to journalArticle

Mucins
Genes
Physiological Phenomena
Lubrication
Glycosylation