Biochemistry and Molecular Biology

Research Output 1993 2018

Article
46 Citations (Scopus)

(R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1

Perrotton, T., Trompier, D., Chang, X-B. D., Di Pietro, A. & Baubichon-Cortay, H., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31542-31548 7 p.

Research output: Contribution to journalArticle

Verapamil
Isomers
Enantiomers
Cricetinae
Glutathione
111 Citations (Scopus)

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Young, H. W. J., Molina, J. G., Dimina, D., Zhong, H., Jacobson, M., Chan, L. N. L., Chan, T. S., Lee, J. J. & Blackburn, M. R., Jul 15 2004, In : Journal of Immunology. 173, 2, p. 1380-1389 10 p.

Research output: Contribution to journalArticle

Adenosine A3 Receptors
Mucus
Eosinophils
Adenosine
Inflammation
37 Citations (Scopus)

A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis

Morschl, E., Molina, J. G., Volmer, J. B., Mohsenin, A., Pero, R. S., Hong, J. S., Kheradmand, F., Lee, J. J. & Blackburn, M. R., Dec 1 2008, In : American Journal of Respiratory Cell and Molecular Biology. 39, 6, p. 697-705 9 p.

Research output: Contribution to journalArticle

Adenosine A3 Receptors
Purinergic P1 Receptors
Pulmonary Fibrosis
Pneumonia
Bleomycin
4 Citations (Scopus)

Aberrant glycosylation of anchor-optimized MUC1 peptides can enhance antigen binding affinity and reverse tolerance to cytotoxic T lymphocytes

Pathangey, L. B., Lakshminarayanan, V., Suman, V. J., Pockaj, B. A., Mukherjee, P. & Gendler, S. J., Sep 1 2016, In : Biomolecules. 6, 3, 31.

Research output: Contribution to journalArticle

Glycosylation
T-cells
Cytotoxic T-Lymphocytes
Anchors
Antigens
89 Citations (Scopus)

Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology

Justice, J. P., Borchers, M. T., Crosby, J. R., Hines, E. M., Shen, H. H., Ochkur, S. I., McGarry, M. P., Lee, N. A. & Lee, J. J., Jan 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 1 28-1

Research output: Contribution to journalArticle

Eosinophils
Allergens
Ovalbumin
Pathology
Lung
289 Citations (Scopus)

Abnormal heart rate regulation in GIRK4 knockout mice

Wickman, K., Nemec, J., Gendler, S. J. & Clapham, D. E., Jan 1998, In : Neuron. 20, 1, p. 103-114 12 p.

Research output: Contribution to journalArticle

Knockout Mice
Heart Rate
Telemetry
Vagus Nerve
Potassium Channels
97 Citations (Scopus)

Absence of Histologic Retinal Toxicity of Intravitreal Bevacizumab in a Rabbit Model

Bakri, S. J., Cameron, J. D., McCannel, C. A., Pulido, J. S. & Marler, R. J., Jul 2006, In : American Journal of Ophthalmology. 142, 1, p. 162-164 3 p.

Research output: Contribution to journalArticle

Rabbits
Microscopy
Optic Nerve
Light
Autolysis
42 Citations (Scopus)

Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model

Bakri, S. J., Pulido, J. S., Mukherjee, P., Marler, R. J. & Mukhopadhyay, D., Jan 2008, In : Retina. 28, 1, p. 147-149 3 p.

Research output: Contribution to journalArticle

Rabbits
Retinal Pigment Epithelium
Optic Nerve
Ganglia
Retina
133 Citations (Scopus)

A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse

Shen, H. H., Ochkur, S. I., McGarry, M. P., Crosby, J. R., Hines, E. M., Borchers, M. T., Wang, H., Biechelle, T. L., O'Neill, K. R., Ansay, T. L., Colbert, D. C., Cormier, S. A., Justice, J. P., Lee, N. A. & Lee, J. J., Mar 15 2003, In : Journal of Immunology. 170, 6, p. 3296-3305 10 p.

Research output: Contribution to journalArticle

Eosinophils
Pathology
Lung
Interleukin-5
Pulmonary Eosinophilia
42 Citations (Scopus)

Activated mouse eosinophils protect against lethal respiratory virus infection

Percopo, C. M., Dyer, K. D., Ochkur, S. I., Luo, J. L., Fischer, E. R., Lee, J. J., Lee, N. A., Domachowske, J. B. & Rosenberg, H. F., Jan 30 2014, In : Blood. 123, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

Virus Diseases
Murine pneumonia virus
Viruses
Eosinophils
Respiratory Tract Infections
19 Citations (Scopus)

Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation

Mielke, C., Lefort, N., McLean, C. G., Cordova, J. M., Langlais, P. R., Bordner, A. J., Te, J. A., Ozkan, S. B., Willis, W. T. & Mandarino, L. J., Jun 17 2014, In : Biochemistry. 53, 23, p. 3817-3829 13 p.

Research output: Contribution to journalArticle

ATP Translocases Mitochondrial ADP
Acetylation
Oxidative Phosphorylation
Adenosine Diphosphate
Muscle
23 Citations (Scopus)

Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice

Klein, I. K., Ritland, S. R., Burgart, L. J., Ziesmer, S. C., Roche, P. C., Gendler, S. J. & Karnes, W. E., Apr 15 2000, In : Cancer Research. 60, 8, p. 2077-2080 4 p.

Research output: Contribution to journalArticle

Adenoma
Protein Kinase C
Isoenzymes
Nuclear Proteins
Epithelium
135 Citations (Scopus)

Adenomatous polyps are drivenbymicrobe-instigated focal inflammation and are controlled by IL-10-producing T cells

Dennis, K. L., Wang, Y., Blatner, N. R., Wang, S., Saadalla, A., Trudeau, E., Roers, A., Weaver, C. T., Lee, J. J., Gilbert, J. A., Chang, E. B. & Khazaie, K., Oct 1 2013, In : Cancer Research. 73, 19, p. 5905-5913 9 p.

Research output: Contribution to journalArticle

Adenomatous Polyps
Interleukin-10
Inflammation
T-Lymphocytes
Polyps
52 Citations (Scopus)

Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Jun 2006, In : Human Gene Therapy. 17, 6, p. 661-668 8 p.

Research output: Contribution to journalArticle

Adenoviridae
Iodides
Mucin-1
Pancreatic Neoplasms
Neoplasms

A downer Nubian goat with coughing

Gades, N. M., Okerman, R., Twernbold, D., Thompson, K., Bjertness, L. & Marler, R. J., Sep 2005, In : Lab Animal. 34, 8, p. 24-25 2 p.

Research output: Contribution to journalArticle

Strongylida Infections
Parasitic Lung Diseases
Metastrongyloidea
Goat Diseases
Lentivirus Infections
6 Citations (Scopus)

A flow cytometry-based assay for procoagulant platelet polyphosphate

Labberton, L., Long, A. T., Gendler, S. J., Snozek, C. L., Stavrou, E. X., Nickel, K. F., Maas, C., Blankenberg, S., Hernandez, J. S. & Renné, T., 2016, (Accepted/In press) In : Cytometry Part B - Clinical Cytometry.

Research output: Contribution to journalArticle

Polyphosphates
Flow Cytometry
Blood Platelets
Thrombin Receptors
Purinergic P2 Receptors
39 Citations (Scopus)

Airway eosinophilia in remission and progression of asthma: Accumulation with a fast decline of FEV1

Broekema, M., Volbeda, F., Timens, W., Dijkstra, A., Lee, N. A., Lee, J. J., Lodewijk, M. E., Postma, D. S., Hylkema, M. N. & Ten Hacken, N. H. T., Sep 2010, In : Respiratory Medicine. 104, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

Eosinophilia
Sputum
Airway Remodeling
Asthma
Eosinophils
18 Citations (Scopus)

A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes

Valencik, M. L., Keller, R. S., Loftus, J. C. & McDonald, J. A., Aug 2002, In : Journal of Cardiac Failure. 8, 4, p. 262-272 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Integrins
Phenotype
Transgenes
Maintenance
19 Citations (Scopus)

Allergen-induced traffic of bone marrow eosinophils, neutrophils and lymphocytes to airways

Johansson, A. K., Sergejeva, S., Sjöstrand, M., Lee, J. J. & Lötvall, J., Nov 2004, In : European Journal of Immunology. 34, 11, p. 3135-3145 11 p.

Research output: Contribution to journalArticle

Eosinophils
Allergens
Neutrophils
Bone Marrow
Lymphocytes
172 Citations (Scopus)

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

Jacobsen, E., Ochkur, S. I., Pero, R. S., Taranova, A. G., Protheroe, C. A., Colbert, D. C., Lee, N. A. & Lee, J. J., Mar 17 2008, In : Journal of Experimental Medicine. 205, 3, p. 699-710 12 p.

Research output: Contribution to journalArticle

Eosinophils
Pneumonia
T-Lymphocytes
Ovalbumin
Lung
36 Citations (Scopus)

Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung

Taranova, A. G., Maldonado, D., Vachon, C. M., Jacobsen, E., Abdala-Valencia, H., McGarry, M. P., Ochkur, S. I., Protheroe, C. A., Doyle, A., Grant, C. S., Cook-Mills, J., Birnbaumer, L., Lee, N. A. & Lee, J. J., Oct 15 2008, In : Cancer Research. 68, 20, p. 8582-8589 8 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Pneumonia
Lung
Allergens
Neoplasm Metastasis
130 Citations (Scopus)

Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1

Hou, Y. X., Cui, L., Riordan, J. R. & Chang, X-B. D., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20280-20287 8 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Nucleotides
Adenosine Triphosphate
Adenine Nucleotides
Adenosine Diphosphate
22 Citations (Scopus)

Altered eosinophil profile in mice with ST6Gal-1 deficiency: An additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation

Nasirikenari, M., Chandrasekaran, E. V., Matta, K. L., Segal, B. H., Bogner, P. N., Lugade, A. A., Thanavala, Y., Lee, J. J. & Lau, J. T. Y., Mar 2010, In : Journal of Leukocyte Biology. 87, 3, p. 457-466 10 p.

Research output: Contribution to journalArticle

Eosinophils
Inflammation
beta-D-galactoside alpha 2-6-sialyltransferase
Pulmonary Eosinophilia
Sialyltransferases
10 Citations (Scopus)

A microsatellite within the MUC1 locus at 1q21 is altered in the neoplastic cells of breast cancer patients

Waltz, M. R., Pandelidis, S. M., Pratt, W., Barnes, D., Swallow, D. M., Gendler, S. J. & Cohen, E. P., Jan 1 1998, In : Cancer Genetics and Cytogenetics. 100, 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Breast Neoplasms
varespladib methyl
BRCA1 Gene
Minisatellite Repeats
44 Citations (Scopus)

A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1

Chang, X-B. D., Mar 2007, In : Cancer and Metastasis Reviews. 26, 1, p. 15-37 23 p.

Research output: Contribution to journalArticle

Multidrug Resistance-Associated Proteins
Multiple Drug Resistance
Adenosine Triphosphate
Pharmaceutical Preparations
Neoplasms
2 Citations (Scopus)

A mutation in the integrin αIIb subunit that selectively inhibits αIIbβ3 receptor function

Perkins, K. B. & Loftus, J. C., Nov 2003, In : Thrombosis and Haemostasis. 90, 5, p. 853-862 10 p.

Research output: Contribution to journalArticle

Integrins
Ligands
Mutation
Blood Platelets
Fibrinogen Receptors
29 Citations (Scopus)

A mutation in the α subunit of the platelet integrin α(IIb)β3 identifies a novel region important for ligand binding

Tozer, E. C., Baker, E. K., Ginsberg, M. H. & Loftus, J. C., Feb 1 1999, In : Blood. 93, 3, p. 918-924 7 p.

Research output: Contribution to journalArticle

Platelets
Integrins
Blood Platelets
Ligands
Mutation
12 Citations (Scopus)

Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model

Pinkhasov, J., Alvarez, M. L., Pathangey, L. B., Tinder, T. L., Mason, H. S., Walmsley, A. M., Gendler, S. J. & Mukherjee, P., Dec 2010, In : Cancer Immunology, Immunotherapy. 59, 12, p. 1801-1811 11 p.

Research output: Contribution to journalArticle

Mucin-1
Cholera Toxin
Proteins
Oligodeoxyribonucleotides
Autoantigens
57 Citations (Scopus)

Analysis of mammalian MUC1 genes reveals potential functionally important domains

Spicer, A. P., Duhig, T., Chilton, B. S. & Gendler, S. J., Dec 1995, In : Mammalian Genome. 6, 12, p. 885-888 4 p.

Research output: Contribution to journalArticle

Nucleic Acid Sequence Homology
Molecular Sequence Data
Hylobates
Amino Acid Sequence Homology
Mucin-1
12 Citations (Scopus)

Analysis of the cellular and molecular mechanisms of trophic action of a misspliced form of the type B cholecystokinin receptor present in colon and pancreatic cancer

Cheng, Z. J., Harikumar, K. G., Ding, W. Q., Holicky, E. L. & Miller, L. J., May 10 2005, In : Cancer Letters. 222, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

Cholecystokinin B Receptor
Pancreatic Neoplasms
Colonic Neoplasms
Cholecystokinin A Receptor
Calcium
13 Citations (Scopus)

An essential role for Rab27a GTPase in eosinophil exocytosis

Kim, J. D., Willetts, L., Ochkur, S., Srivastava, N., Hamburg, R., Shayeganpour, A., Seabra, M. C., Lee, J. J., Moqbel, R. & Lacy, P., Dec 2013, In : Journal of Leukocyte Biology. 94, 6, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Exocytosis
Eosinophils
Fluorescent Antibody Technique
rab GTP-Binding Proteins
7 Citations (Scopus)

A new formulation of protein evolutionary models that account for structural constraints

Bordner, A. J. & Mittelmann, H. D., 2014, In : Molecular Biology and Evolution. 31, 3, p. 736-749 14 p.

Research output: Contribution to journalArticle

Structural Models
protein
Amino Acids
Proteins
proteins
9 Citations (Scopus)

A novel CFTR disease-associated mutation causes addition of an extra N-linked oligosaccharide

Hämmerle, M. M., Aleksandrov, A. A., Chang, X-B. D. & Riordan, J. R., 2000, In : Glycoconjugate Journal. 17, 11, p. 807-813 7 p.

Research output: Contribution to journalArticle

Oligosaccharides
Membranes
Mutation
Consensus Sequence
Calnexin
131 Citations (Scopus)

A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis

Protheroe, C., Woodruff, S. A., de Petris, G., Mukkada, V., Ochkur, S. I., Janarthanan, S., Lewis, J. C., Pasha, S. F., Lunsford, T., Harris, L., Sharma, V. K., McGarry, M. P., Lee, N. A., Furuta, G. T. & Lee, J. J., Jul 2009, In : Clinical Gastroenterology and Hepatology. 7, 7

Research output: Contribution to journalArticle

Eosinophilic Esophagitis
Eosinophilia
Biopsy
Gastroesophageal Reflux
Eosinophil Peroxidase
4 Citations (Scopus)

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

Ding, Z., Roos, A., Kloss, J., Dhruv, H., Peng, S., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Feb 1 2018, In : Molecular Cancer Research. 16, 2, p. 322-332 11 p.

Research output: Contribution to journalArticle

Glioblastoma
temozolomide
Neoplasms
Epidermal Growth Factor
Survival
2 Citations (Scopus)
Fluorescence Resonance Energy Transfer
Fluorescence
Ligands
Secretin
Energy Transfer
4 Citations (Scopus)

Applications of fluorescence in the characterization of the ligand-binding domain and activation of the cholecystokinin receptor

Harikumar, K. G. & Miller, L. J., Dec 1 2002, In : Pharmacology and Toxicology. 91, 6, p. 286-289 4 p.

Research output: Contribution to journalArticle

Cholecystokinin Receptors
Fluorescence
Chemical activation
Ligands
Guanine Nucleotides
49 Citations (Scopus)

A preclinical large animal model of adenovirus-mediated expression of the sodium-iodide symporter for radioiodide imaging and therapy of locally recurrent prostate cancer

Dwyer, R. M., Schatz, S. M., Bergert, E. R., Myers, R. M., Harvey, M. E., Classic, K. L., Blanco, M. C., Frisk, C. S., Marler, R. J., Davis, B. J., O'Connor, M. K., Russell, S. J. & Morris, J. C., Nov 2005, In : Molecular Therapy. 12, 5, p. 835-841 7 p.

Research output: Contribution to journalArticle

Adenoviridae
Prostatic Neoplasms
Animal Models
Prostate
Iodides
Mucins
Genes
Mucus
Cysteine
Membranes
17 Citations (Scopus)

A sensitive high throughput ELISA for human eosinophil peroxidase: A specific assay to quantify eosinophil degranulation from patient-derived sources

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Condjella, R. M., Bersoux, S., Helmers, R. A., Moqbel, R., Lacy, P., Kelly, E. A., Jarjour, N. N., Kern, R., Peters, A., Schleimer, R. P., Furuta, G. T., Nair, P., Lee, J. J. & Lee, N. A., Oct 31 2012, In : Journal of Immunological Methods. 384, 1-2, p. 10-20 11 p.

Research output: Contribution to journalArticle

Eosinophil Peroxidase
Eosinophils
Enzyme-Linked Immunosorbent Assay
Ribonucleases
Nasal Lavage

Assembly and glycosylation of gel forming mucins: Implications for cystic fibrosis

Hansson, G. C., Axelsson, M. A. B., Asker, N., Johansson, M. E. V., Steel, D. M., Thomsson, K. A., Lindgren, K. A. S., Axelsson, K. A., Hinojosa-Kutzberg, M., Gendler, S. J., Nilsson, T. & Karlsson, N. G., Sep 1999, In : Pediatric Pulmonology. 28, SUPPL. 19, p. 142-143 2 p.

Research output: Contribution to journalArticle

Mucins
Glycosylation
Cystic Fibrosis
Gels
14 Citations (Scopus)
Molecular crystals
Noble Gases
lattice energy
Discrete Fourier transforms
crystal lattices
15 Citations (Scopus)

Asthma: Does IL-5 Have a More Provocative Role?

Lee, N. A. & Lee, J. J., 1997, In : American Journal of Respiratory Cell and Molecular Biology. 16, 5, p. 497-500 4 p.

Research output: Contribution to journalArticle

Animal Disease Models
Interleukin-5
Ovalbumin
Bronchi
Eosinophils
424 Citations (Scopus)

A tale of two controversies. Defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species

Brennan, M. L., Wu, W., Fu, X., Shen, Z., Song, W., Frost, H., Vadseth, C., Narine, L., Lenkiewicz, E., Borchers, M. T., Lusis, A. J., Lee, J. J., Lee, N. A., Abu-Soud, H. M., Ischiropoulos, H. & Hazen, S. L., May 17 2002, In : Journal of Biological Chemistry. 277, 20, p. 17415-17427 13 p.

Research output: Contribution to journalArticle

Eosinophil Peroxidase
Reactive Nitrogen Species
Peroxidases
Peroxidase
Oxidation
128 Citations (Scopus)

ATPase activity of purified multidrug resistance-associated protein

Chang, X-B. D., Hou, Y. X. & Riordan, J. R., Dec 5 1997, In : Journal of Biological Chemistry. 272, 49, p. 30962-30968 7 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Multidrug Resistance-Associated Proteins
Adenosine Triphosphatases
Purification
Membranes
31 Citations (Scopus)

ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP·Vi trapping at the second domain

Hou, Y. X., Riordan, J. R. & Chang, X-B. D., Feb 7 2003, In : Journal of Biological Chemistry. 278, 6, p. 3599-3605 7 p.

Research output: Contribution to journalArticle

Multidrug Resistance-Associated Proteins
Hydrolysis
Nucleotides
Adenosine Triphosphate
Adenosine Diphosphate
41 Citations (Scopus)
Multidrug Resistance-Associated Proteins
Leukotriene C4
Hydrolysis
Nucleotides
Adenosine Triphosphate
52 Citations (Scopus)

ATP binding to the first nucleotide-binding domain of multidrug resistance protein MRP1 increases binding and hydrolysis of ATP and trapping of ADP at the second domain

Hou, Y. X., Cui, L., Riordan, J. R. & Chang, X-B. D., Feb 15 2002, In : Journal of Biological Chemistry. 277, 7, p. 5110-5119 10 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Adenosine Diphosphate
Hydrolysis
Nucleotides
Adenosine Triphosphate
11 Citations (Scopus)

A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment

Desai, A. J., Harikumar, K. G. & Miller, L. J., Jun 27 2014, In : Journal of Biological Chemistry. 289, 26, p. 18314-18326 13 p.

Research output: Contribution to journalArticle

Cholecystokinin A Receptor
Cholecystokinin Receptors
Cholecystokinin
Cholesterol
Ligands
67 Citations (Scopus)

Bacterial conjunctivitis in Muc1 null mice

Kardon, R., Price, R. E., Julian, J., Lagow, E., Tseng, S. C. G., Gendler, S. J. & Carson, D. D., 1999, In : Investigative Ophthalmology and Visual Science. 40, 7, p. 1328-1335 8 p.

Research output: Contribution to journalArticle

Bacterial Conjunctivitis
Harderian Gland
Keratin-14
Wild Animals
Antibodies