Biochemistry and Molecular Biology

Research Output

Article

(R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1

Perrotton, T., Trompier, D., Chang, X. B., Di Pietro, A. & Baubichon-Cortay, H., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31542-31548 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Young, H. W. J., Molina, J. G., Dimina, D., Zhong, H., Jacobson, M., Chan, L. N. L., Chan, T. S., Lee, J. J. & Blackburn, M. R., Jul 15 2004, In : Journal of Immunology. 173, 2, p. 1380-1389 10 p.

Research output: Contribution to journalArticle

Open Access
111 Scopus citations

A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis

Morschl, E., Molina, J. G., Volmer, J. B., Mohsenin, A., Pero, R. S., Hong, J. S., Kheradmand, F., Lee, J. J. & Blackburn, M. R., Dec 1 2008, In : American journal of respiratory cell and molecular biology. 39, 6, p. 697-705 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Aberrant glycosylation of anchor-optimized MUC1 peptides can enhance antigen binding affinity and reverse tolerance to cytotoxic T lymphocytes

Pathangey, L. B., Lakshminarayanan, V., Suman, V. J., Pockaj, B. A., Mukherjee, P. & Gendler, S. J., Sep 2016, In : Biomolecules. 6, 3, 31.

Research output: Contribution to journalArticle

5 Scopus citations

Ab initio prediction of peptide-MHC binding geometry for diverse class I MHC allotypes

Bordner, A. J. & Abagyan, R., May 15 2006, In : Proteins: Structure, Function and Genetics. 63, 3, p. 512-526 15 p.

Research output: Contribution to journalArticle

63 Scopus citations

Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology

Justice, J. P., Borchers, M. T., Crosby, J. R., Hines, E. M., Shen, H. H., Ochkur, S. I., McGarry, M. P., Lee, N. A. & Lee, J. J., Jan 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 1 28-1, p. L169-L178

Research output: Contribution to journalArticle

89 Scopus citations

Abnormal heart rate regulation in GIRK4 knockout mice

Wickman, K., Nemec, J., Gendler, S. J. & Clapham, D. E., Jan 1998, In : Neuron. 20, 1, p. 103-114 12 p.

Research output: Contribution to journalArticle

297 Scopus citations

Absence of Histologic Retinal Toxicity of Intravitreal Bevacizumab in a Rabbit Model

Bakri, S. J., Cameron, J. D., McCannel, C. A., Pulido, J. S. & Marler, R. J., Jul 1 2006, In : American journal of ophthalmology. 142, 1, p. 162-164 3 p.

Research output: Contribution to journalArticle

98 Scopus citations

Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model

Bakri, S. J., Pulido, J. S., Mukherjee, P., Marler, R. J. & Mukhopadhyay, D., Jan 1 2008, In : Retina. 28, 1, p. 147-149 3 p.

Research output: Contribution to journalArticle

44 Scopus citations

A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse

Shen, H. H. H., Ochkur, S. I., McGarry, M. P., Crosby, J. R., Hines, E. M., Borchers, M. T., Wang, H., Biechelle, T. L., O'Neill, K. R., Ansay, T. L., Colbert, D. C., Cormier, S. A., Justice, J. P., Lee, N. A. & Lee, J. J., Mar 15 2003, In : Journal of Immunology. 170, 6, p. 3296-3305 10 p.

Research output: Contribution to journalArticle

Open Access
139 Scopus citations

Accurate transferable model for water, n-octanol, and n-hexadecane solvation free energies

Bordner, A. J., Cavasotto, C. N. & Abagyan, R. A., Oct 24 2002, In : Journal of Physical Chemistry B. 106, 42, p. 11009-11015 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM‐3 is selectively exposed in a range of primary carcinomas

Girling, A., Bartkova, J., Burchell, J., Gendler, S., Gillett, C. & Taylor‐Papadimitriou, J., Jun 15 1989, In : International Journal of Cancer. 43, 6, p. 1072-1076 5 p.

Research output: Contribution to journalArticle

295 Scopus citations

Activated mouse eosinophils protect against lethal respiratory virus infection

Percopo, C. M., Dyer, K. D., Ochkur, S. I., Luo, J. L., Fischer, E. R., Lee, J. J., Lee, N. A., Domachowske, J. B. & Rosenberg, H. F., Jan 30 2014, In : Blood. 123, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Active proteinase inhibitors associated with human breast cancer cells

Gendler, S. J. & Tokes, Z. A., Jan 1 1985, In : Proceedings of the American Association for Cancer Research. VOL. 26, p. No. 216

Research output: Contribution to journalArticle

Active proteinase inhibitors associated with human breast epithelial cells

Gendler, S. J. & TőKés, Z. A., 1984, In : Journal of cellular biochemistry. 26, 3, p. 157-167 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation

Mielke, C., Lefort, N., McLean, C. G., Cordova, J. M., Langlais, P. R., Bordner, A. J., Te, J. A., Ozkan, S. B., Willis, W. T. & Mandarino, L. J., Jun 17 2014, In : Biochemistry. 53, 23, p. 3817-3829 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice

Klein, I. K., Ritland, S. R., Burgart, L. J., Ziesmer, S. C., Roche, P. C., Gendler, S. J. & Karnes, W. E., Apr 15 2000, In : Cancer research. 60, 8, p. 2077-2080 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Adenomatous polyps are drivenbymicrobe-instigated focal inflammation and are controlled by IL-10-producing T cells

Dennis, K. L., Wang, Y., Blatner, N. R., Wang, S., Saadalla, A., Trudeau, E., Roers, A., Weaver, C. T., Lee, J. J., Gilbert, J. A., Chang, E. B. & Khazaie, K., Oct 1 2013, In : Cancer research. 73, 19, p. 5905-5913 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Jun 2006, In : Human gene therapy. 17, 6, p. 661-668 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

A downer Nubian goat with coughing

Gades, N. M., Okerman, R., Twernbold, D., Thompson, K., Bjertness, L. & Marler, R., Sep 1 2005, In : Lab Animal. 34, 8, p. 24-25 2 p.

Research output: Contribution to journalArticle

Affinity modulation of the αIIbβ3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor

O'Toole, T. E., Loftus, J. C., Du, X., Glass, A. A., Ruggeri, Z. M., Shattil, S. J., Plow, E. F. & Ginsberg, M. H., Nov 1990, In : Molecular biology of the cell. 1, 12, p. 883-893 11 p.

Research output: Contribution to journalArticle

219 Scopus citations

A flow cytometry-based assay for procoagulant platelet polyphosphate

Labberton, L., Long, A. T., Gendler, S. J., Snozek, C. L., Stavrou, E. X., Nickel, K. F., Maas, C., Blankenberg, S., Hernandez, J. S. & Renné, T., 2016, (Accepted/In press) In : Cytometry Part B - Clinical Cytometry.

Research output: Contribution to journalArticle

8 Scopus citations

A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro

Baker, E. K., Tozer, E. C., Pfaff, M., Shattil, S. J., Loftus, J. C. & Ginsberg, M. H., Mar 4 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 5, p. 1973-1978 6 p.

Research output: Contribution to journalArticle

63 Scopus citations

A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats

Gendler, S., Taylor-Papadimitriou, J., Duhig, T., Rothbard, J. & Burchel, J., Jan 1 1988, In : Journal of Biological Chemistry. 263, 26, p. 12820-12823 4 p.

Research output: Contribution to journalArticle

474 Scopus citations

Airway eosinophilia in remission and progression of asthma: Accumulation with a fast decline of FEV1

Broekema, M., Volbeda, F., Timens, W., Dijkstra, A., Lee, N. A., Lee, J. J., Lodewijk, M. E., Postma, D. S., Hylkema, M. N. & Ten Hacken, N. H. T., Sep 1 2010, In : Respiratory Medicine. 104, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes

Valencik, M. L., Keller, R. S., Loftus, J. C. & McDonald, J. A., Aug 2002, In : Journal of Cardiac Failure. 8, 4, p. 262-272 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Allergen-induced traffic of bone marrow eosinophils, neutrophils and lymphocytes to airways

Johansson, A. K., Sergejeva, S., Sjöstrand, M., Lee, J. J. & Lötvall, J., Nov 1 2004, In : European Journal of Immunology. 34, 11, p. 3135-3145 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

Jacobsen, E. A., Ochkur, S. I., Pero, R. S., Taranova, A. G., Protheroe, C. A., Colbert, D. C., Lee, N. A. & Lee, J. J., Mar 17 2008, In : Journal of Experimental Medicine. 205, 3, p. 699-710 12 p.

Research output: Contribution to journalArticle

177 Scopus citations

Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung

Taranova, A. G., Maldonado, D., Vachon, C. M., Jacobsen, E. A., Abdala-Valencia, H., McGarry, M. P., Ochkur, S. I., Protheroe, C. A., Doyle, A., Grant, C. S., Cook-Mills, J., Birnbaumer, L., Lee, N. A. & Lee, J. J., Oct 15 2008, In : Cancer research. 68, 20, p. 8582-8589 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1

Hou, Y. X., Cui, L., Riordan, J. R. & Chang, X. B., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20280-20287 8 p.

Research output: Contribution to journalArticle

131 Scopus citations

Altered eosinophil profile in mice with ST6Gal-1 deficiency: An additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation

Nasirikenari, M., Chandrasekaran, E. V., Matta, K. L., Segal, B. H., Bogner, P. N., Lugade, A. A., Thanavala, Y., Lee, J. J. & Lau, J. T. Y., Mar 1 2010, In : Journal of Leukocyte Biology. 87, 3, p. 457-466 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Alternative proteolytic processing of platelet membrane glycoprotein IIb

Loftus, J. C., Plow, E. F., Jennings, L. K. & Ginsberg, M. H., Jan 1 1988, In : Journal of Biological Chemistry. 263, 23, p. 11025-11028 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

A microsatellite within the MUC1 locus at 1q21 is altered in the neoplastic cells of breast cancer patients

Waltz, M. R., Pandelidis, S. M., Pratt, W., Barnes, D., Swallow, D. M., Gendler, S. J. & Cohen, E. P., Jan 1 1998, In : Cancer Genetics and Cytogenetics. 100, 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

A molecular basis for affinity modulation of Fab ligand binding to integrin α(IIb)β3

Kunicki, T. J., Annis, D. S., Deng, Y. J., Loftus, J. C. & Shattil, S. J., Sep 5 1996, In : Journal of Biological Chemistry. 271, 34, p. 20315-20321 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

A mutation in the integrin αIIb subunit that selectively inhibits αIIbβ3 receptor function

Perkins, K. B. & Loftus, J. C., Nov 2003, In : Thrombosis and Haemostasis. 90, 5, p. 853-862 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

A mutation in the α subunit of the platelet integrin α(IIb)β3 identifies a novel region important for ligand binding

Tozer, E. C., Baker, E. K., Ginsberg, M. H. & Loftus, J. C., Feb 1 1999, In : Blood. 93, 3, p. 918-924 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model

Pinkhasov, J., Alvarez, M. L., Pathangey, L. B., Tinder, T. L., Mason, H. S., Walmsley, A. M., Gendler, S. J. & Mukherjee, P., Dec 1 2010, In : Cancer Immunology, Immunotherapy. 59, 12, p. 1801-1811 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Analysis of mammalian MUC1 genes reveals potential functionally important domains

Spicer, A. P., Duhig, T., Chilton, B. S. & Gendler, S. J., Dec 1 1995, In : Mammalian Genome. 6, 12, p. 885-888 4 p.

Research output: Contribution to journalArticle

57 Scopus citations

Analysis of the cellular and molecular mechanisms of trophic action of a misspliced form of the type B cholecystokinin receptor present in colon and pancreatic cancer

Cheng, Z. J., Harikumar, K. G., Ding, W. Q., Holicky, E. L. & Miller, L. J., May 10 2005, In : Cancer Letters. 222, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Analysis of the tissue-specific promoter of the MUC1 gene

Kovarik, A., Peat, N., Wilson, D., Gendler, S. J. & Taylor-Papadimitriou, J., Jan 1 1993, In : Journal of Biological Chemistry. 268, 13, p. 9917-9926 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

Androgen receptor-positive triple negative breast cancer: A unique breast cancer subtype

McGhan, L. J., McCullough, A. E., Protheroe, C. A., Dueck, A. C., Lee, J. J., Nunez-Nateras, R., Castle, E. P., Gray, R. J., Wasif, N., Goetz, M. P., Hawse, J. R., Henry, T. J., Barrett, M. T., Cunliffe, H. E. & Pockaj, B. A., Feb 1 2014, In : Annals of surgical oncology. 21, 2, p. 361-367 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

An essential role for Rab27a GTPase in eosinophil exocytosis

Kim, J. D., Willetts, L., Ochkur, S., Srivastava, N., Hamburg, R., Shayeganpour, A., Seabra, M. C., Lee, J. J., Moqbel, R. & Lacy, P., Dec 1 2013, In : Journal of Leukocyte Biology. 94, 6, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

A new formulation of protein evolutionary models that account for structural constraints

Bordner, A. J. & Mittelmann, H. D., Mar 2014, In : Molecular biology and evolution. 31, 3, p. 736-749 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

A novel CFTR disease-associated mutation causes addition of an extra N-linked oligosaccharide

Hämmerle, M. M., Aleksandrov, A. A., Chang, X. B. & Riordan, J. R., Jan 1 2000, In : Glycoconjugate Journal. 17, 11, p. 807-813 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis

Protheroe, C., Woodruff, S. A., de Petris, G., Mukkada, V., Ochkur, S. I., Janarthanan, S., Lewis, J. C., Pasha, S., Lunsford, T., Harris, L., Sharma, V. K., McGarry, M. P., Lee, N. A., Furuta, G. T. & Lee, J. J., Jul 2009, In : Clinical Gastroenterology and Hepatology. 7, 7, p. 749-755.e11

Research output: Contribution to journalArticle

138 Scopus citations

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

Ding, Z., Roos, A., Kloss, J., Dhruv, H., Peng, S., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Feb 1 2018, In : Molecular Cancer Research. 16, 2, p. 322-332 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Antibodies to the cytoplasmic domain of the MUC1 mucin show conservation throughout mammals

Pemberton, L., Taylor-Papadimitriou, J. & Gendler, S. J., May 29 1992, In : Biochemical and Biophysical Research Communications. 185, 1, p. 167-175 9 p.

Research output: Contribution to journalArticle

119 Scopus citations

Anti-CD86 (B7.2) Treatment abolishes allergic airway hyperresponsiveness in mice

Haczku, A., Takeda, K., Redai, I., Hamelmann, E., Cieslewicz, G., Joetham, A., Loader, J., Lee, J. J., Irvin, C. & Gelfand, E. W., Jan 1 1999, In : American journal of respiratory and critical care medicine. 159, 5 I, p. 1638-1643 6 p.

Research output: Contribution to journalArticle

94 Scopus citations

Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model airway sensitization

Hamelmann, E., Oshiba, A., Loader, J., Larsen, C. L., Gleich, C., Lee, J. & Gelfand, E. W., Jan 1 1997, In : American journal of respiratory and critical care medicine. 155, 3, p. 819-825 7 p.

Research output: Contribution to journalArticle

242 Scopus citations
2 Scopus citations