Biochemistry and Molecular Biology

Research Output 1993 2018

Filter
Article
2018
4 Citations (Scopus)

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

Ding, Z., Roos, A., Kloss, J., Dhruv, H., Peng, S., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Feb 1 2018, In : Molecular Cancer Research. 16, 2, p. 322-332 11 p.

Research output: Contribution to journalArticle

Glioblastoma
temozolomide
Neoplasms
Epidermal Growth Factor
Survival
6 Citations (Scopus)

Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

O'Sullivan, J. A., Wei, Y., Carroll, D. J., Moreno-Vinasco, L., Cao, Y., Zhang, F., Lee, J. J., Zhu, Z. & Bochner, B. S., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Eosinophils
Mast Cells
CXCR3 Receptors
Death Domain Receptors
4 Citations (Scopus)

EGFRvIII–Stat5 signaling enhances glioblastoma cell migration and survival

Roos, A., Dhruv, H. D., Peng, S., Inge, L. J., Tuncali, S., Pineda, M., Millard, N., Mayo, Z., Eschbacher, J. M., Loftus, J. C., Winkles, J. A. & Tran, N., Jul 1 2018, In : Molecular Cancer Research. 16, 7, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Movement
Cell Survival
Neoplasms
Pimozide
1 Citation (Scopus)

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis

Zhang, C., Yi, W., Li, F., Du, X., Wang, H., Wu, P., Peng, C., Luo, M., Hua, W., Wong, C. C. L., Lee, J. J., Li, W., Chen, Z., Ying, S., Ju, Z. & Shen, H., Mar 1 2018, In : Cell Research. 28, 3, p. 323-335 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Eosinophils
Homeostasis
Ovalbumin
Eosinophilia
16 Citations (Scopus)

Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid

Lin, L., Hwang, B. J., Culton, D. A., Li, N., Burette, S., Koller, B. H., Messingham, K. A., Fairley, J. A., Lee, J. J., Hall, R. P., An, L., Diaz, L. A. & Liu, Z., May 1 2018, In : Journal of Investigative Dermatology. 138, 5, p. 1032-1043 12 p.

Research output: Contribution to journalArticle

Bullous Pemphigoid
Skin Diseases
Eosinophils
Autoimmune Diseases
Skin
2 Citations (Scopus)

Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease

Wright, B., Nguyen, N., Shim, K. P., Masterson, J. C., Jacobsen, E., Ochkur, S. I., Lee, J. J. & Furuta, G. T., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Eosinophilic Esophagitis
Gastroesophageal Reflux
1 Citation (Scopus)

Inhibiting focal adhesion kinase (FAK) blocks IL-4 induced VCAM-1 expression and eosinophil recruitment in vitro and in vivo

Aulakh, G. K., Petri, B., Wojcik, K. M., Colarusso, P., Lee, J. J. & Patel, K. D., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Vascular Cell Adhesion Molecule-1
Eosinophils
Interleukin-4
Emigration and Immigration
14 Citations (Scopus)

Methylprednisolone acetate induces, and ?7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

Patton, J. B., Bonne-Année, S., Deckman, J., Hess, J. A., Torigian, A., Nolan, T. J., Wang, Z., Kliewer, S. A., Durham, A. C., Lee, J. J., Eberhard, M. L., Mangelsdorf, D. J., Lok, J. B. & Abraham, D., Jan 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 1, p. 204-209 6 p.

Research output: Contribution to journalArticle

Strongyloides stercoralis
Larva
Glucocorticoids
methylprednisolone acetate
dafachronic acid
3 Citations (Scopus)

Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications

Lugogo, N., Francisco, D., Addison, K. J., Manne, A., Pederson, W., Ingram, J. L., Green, C. L., Suratt, B. T., Lee, J. J., Sunday, M. E., Kraft, M. & Ledford, J. G., Mar 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 3, p. 918-926.e3

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Asthma
Eosinophils
Eosinophilia
Allergens

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival

Ding, Z., Dhruv, H., Kwiatkowska-Piwowarczyk, A., Ruggieri, R., Kloss, J., Symons, M., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Oct 1 2018, In : Neoplasia (United States). 20, 10, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Glioblastoma
Cell Survival
Glioma
Cell Movement
15 Citations (Scopus)

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

Abdala-Valencia, H., Coden, M. E., Chiarella, S. E., Jacobsen, E., Bochner, B. S., Lee, J. J. & Berdnikovs, S., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

Eosinophils
Homeostasis
Hematopoiesis
Thromboplastin
Phenotype
1 Citation (Scopus)

Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice

Willetts, L., Felix, L. C., Jacobsen, E., Puttagunta, L., Condjella, R. M., Zellner, K. R., Ochkur, S. I., Kim, J. D., Luo, H., Lee, N. A., Lee, J. J., Moqbel, R. & Lacy, P., Dec 1 2018, In : Communications Biology. 1, 1, 83.

Research output: Contribution to journalArticle

Open Access
R-SNARE Proteins
eosinophils
Eosinophils
membrane proteins
inflammation
2017
2 Citations (Scopus)

Chemotherapy can induce weight normalization of morbidly obese mice despite undiminished ingestion of high fat diet

Myers, C. E., Hoelzinger, D. B., Truong, T. N., Chew, L. A., Myles, A., Chaudhuri, L., Egan, J. B., Liu, J. D., Gendler, S. J. & Cohen, P. A., 2017, In : Oncotarget. 8, 3, p. 5426-5438 13 p.

Research output: Contribution to journalArticle

Obese Mice
High Fat Diet
Methotrexate
Weight Loss
Eating
7 Citations (Scopus)

Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1

Elgilani, F., Mao, S. A., Glorioso, J. M., Yin, M., Iankov, I. D., Singh, A., Amiot, B., Rinaldo, P., Marler, R. J., Ehman, R. L., Grompe, M., Lillegard, J. B., Hickey, R. & Nyberg, S., Jan 1 2017, In : American Journal of Pathology. 187, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Tyrosinemias
Swine
Animal Models
Phenotype
Fibrosis
3 Citations (Scopus)

Coexpressed class B G protein-coupled secretin and GLP-1 receptors self-and cross-associate: Impact on pancreatic islets

Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., Jun 1 2017, In : Endocrinology. 158, 6, p. 1685-1700 16 p.

Research output: Contribution to journalArticle

Secretin
Peptide Receptors
Islets of Langerhans
GTP-Binding Proteins
Calcium
1 Citation (Scopus)

CRISPR/Cas9-Mediated Three Nucleotide Insertion Corrects a Deletion Mutation in MRP1/ABCC1 and Restores Its Proper Folding and Function

Xu, Q., Hou, Y. X. & Chang, X-B. D., Jun 1 2017, In : Molecular Therapy - Nucleic Acids. 7, p. 429-438 10 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Sequence Deletion
Nucleotides
Genetic Recombination
Guide RNA
11 Citations (Scopus)

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

Yan, Y., Xu, T. H., Harikumar, K. G., Miller, L. J., Melcher, K. & Xu, H. E., Sep 22 2017, In : Journal of Biological Chemistry. 292, 38, p. 15826-15837 12 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Dimerization
Amyloid beta-Protein Precursor
Assays
Membranes
21 Citations (Scopus)

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

Uderhardt, S., Ackermann, J. A., Fillep, T., Hammond, V. J., Willeit, J., Santer, P., Mayr, M., Biburger, M., Miller, M., Zellner, K. R., Stark, K., Zarbock, A., Rossaint, J., Schubert, I., Mielenz, D., Dietel, B., Raaz-Schrauder, D., Ay, C., Gremmel, T., Thaler, J. & 14 others, Heim, C., Herrmann, M., Collins, P. W., Schabbauer, G., Mackman, N., Voehringer, D., Nadler, J. L., Lee, J. J., Massberg, S., Rauh, M., Kiechl, S., Schett, G., O'Donnell, V. B. & Krönke, G., Jul 1 2017, In : Journal of Experimental Medicine. 214, 7, p. 2121-2138 18 p.

Research output: Contribution to journalArticle

Hemostasis
Eosinophils
Thrombosis
Lipids
Phosphatidylethanolamines
30 Citations (Scopus)

Eosinophils promote antiviral immunity in mice infected with influenza A virus

Samarasinghe, A. E., Melo, R. C. N., Duan, S., Le Messurier, K. S., Liedmann, S., Surman, S. L., Lee, J. J., Hurwitz, J. L., Thomas, P. G. & McCullers, J. A., Apr 15 2017, In : Journal of Immunology. 198, 8, p. 3214-3226 13 p.

Research output: Contribution to journalArticle

Influenza A virus
Eosinophils
Antiviral Agents
Immunity
Virus Diseases
3 Citations (Scopus)

Frontline science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation

Ochkur, S. I., Doyle, A. D., Jacobsen, E., LeSuer, W. E., Li, W., Protheroe, C. A., Zellner, K. R., Colbert, D., Shen, H. H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., Sep 1 2017, In : Journal of Leukocyte Biology. 102, 3, p. 589-599 11 p.

Research output: Contribution to journalArticle

Eosinophil Major Basic Protein
Eosinophil Peroxidase
Airway Remodeling
Knockout Mice
Eosinophils
10 Citations (Scopus)

Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells

Roos, A., Dhruv, H. D., Mathews, I. T., Inge, L. J., Tuncali, S., Hartman, L. K., Chow, D., Millard, N., Yin, H. H., Kloss, J., Loftus, J. C., Winkles, J. A., Berens, M. E. & Tran, N., 2017, In : Oncotarget. 8, 7, p. 12234-12246 13 p.

Research output: Contribution to journalArticle

Aurintricarboxylic Acid
Glioblastoma
Glioma
temozolomide
Cell Survival
8 Citations (Scopus)

Lung pathologies in a chronic inflammation mouse model are independent of eosinophil degranulation

Jacobsen, E., Ochkur, S. I., Doyle, A. D., LeSuer, W. E., Li, W., Protheroe, C. A., Colbert, D., Zellner, K. R., Shen, H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., May 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1321-1332 12 p.

Research output: Contribution to journalArticle

Eosinophils
Pathology
Inflammation
Lung
Eosinophil Peroxidase
3 Citations (Scopus)

Mouse monoclonal antibodies generated from full length human cereblon: Detection of cereblon protein in patients with multiple myeloma

Chang, X-B. D., Xu, Q., Hou, Y., Li, C., Xu, Y. & Stewart, A. K., Sep 17 2017, In : International Journal of Molecular Sciences. 18, 9, 1999.

Research output: Contribution to journalArticle

Epitopes
Proteasome Inhibitors
Monoclonal antibodies
antibodies
Multiple Myeloma
47 Citations (Scopus)

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Baxter, L. C., Gaw, N., Ranjbar, S., Plasencia, J., Dueck, A., Peng, S., Smith, K. A., Nakaji, P., Karis, J. P., Quarles, C. C., Wu, T., Loftus, J. C., Jenkins, R. B., Sicotte, H., Kollmeyer, T. M., O'Neill, B. P., Elmquist, W. & 7 others, Hoxworth, J. M., Frakes, D., Sarkaria, J. N., Swanson, K., Tran, N., Li, J. & Mitchell, J. R., 2017, In : Neuro-Oncology. 19, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Glioblastoma
erbB-1 Genes
Neoplasms
Biopsy
22 Citations (Scopus)

SiglecF+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice

Percopo, C. M., Brenner, T. A., Ma, M., Kraemer, L. S., Hakeem, R. M. A., Lee, J. J. & Rosenberg, H. F., Jan 1 2017, In : Journal of Leukocyte Biology. 101, 1, p. 321-328 8 p.

Research output: Contribution to journalArticle

Eosinophils
Allergens
Lung
Cytokines
Population
1 Citation (Scopus)

Skeletal and uterotrophic effects of endoxifen in female rats

Gingery, A., Iwaniec, U. T., Subramaniam, M., Turner, R. T., Pitel, K. S., McGovern, R. M., Reid, J. M., Marler, R. J., Ingle, J. N., Goetz, M. P. & Hawse, J. R., Oct 1 2017, In : Endocrinology. 158, 10, p. 3354-3368 15 p.

Research output: Contribution to journalArticle

Tamoxifen
Uterus
Bone and Bones
Epithelial Cells
Breast Neoplasms
10 Citations (Scopus)

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

Ward, R. J., Pediani, J. D., Harikumar, K. G., Miller, L. J. & Milligan, G., Jun 1 2017, In : Biochemical Journal. 474, 11, p. 1879-1895 17 p.

Research output: Contribution to journalArticle

Secretin
Dimerization
Cell membranes
GTP-Binding Proteins
Receptor-Interacting Protein Serine-Threonine Kinases
16 Citations (Scopus)

Sputum autoantibodies in patients with severe eosinophilic asthma

Mukherjee, M., Bulir, D. C., Radford, K., Kjarsgaard, M., Huang, C. M., Jacobsen, E., Ochkur, S. I., Catuneanu, A., Lamothe-Kipnes, H., Mahony, J., Lee, J. J., Lacy, P. & Nair, P. K., Jan 1 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Sputum
Autoantibodies
Asthma
Eosinophils
Eosinophil Peroxidase
5 Citations (Scopus)

Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens

Pathangey, L. B., McCurry, D. B., Gendler, S. J., Dominguez, A. L., Gorman, J. E., Pathangey, G., Mihalik, L. A., Dang, Y., Disis, M. L. & Cohen, P. A., 2017, In : Oncotarget. 8, 7, p. 10785-10808 24 p.

Research output: Contribution to journalArticle

Interleukin-7
Neoplasm Antigens
Innate Immunity
Blood Cells
T-Lymphocytes
1 Citation (Scopus)

Synthesis and Immunological Evaluation of a Multicomponent Cancer Vaccine Candidate Containing a Long MUC1 Glycopeptide

Supekar, N. T., Lakshminarayanan, V., Capicciotti, C. J., Sirohiwal, A., Madsen, C. S., Wolfert, M. A., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 1 2017, (Accepted/In press) In : ChemBioChem.

Research output: Contribution to journalArticle

Cancer Vaccines
Glycopeptides
T-cells
Epitopes
Tumors
19 Citations (Scopus)

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

DeBruine, Z. J., Ke, J., Harikumar, K. G., Gu, X., Borowsky, P., Williams, B. O., Xu, W., Miller, L. J., Xu, H. E. & Melcher, K., 2017, In : Genes and Development. 31, 9, p. 916-926 11 p.

Research output: Contribution to journalArticle

Dimerization
Cysteine
Frizzled Receptors
Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-5
2016
4 Citations (Scopus)

Aberrant glycosylation of anchor-optimized MUC1 peptides can enhance antigen binding affinity and reverse tolerance to cytotoxic T lymphocytes

Pathangey, L. B., Lakshminarayanan, V., Suman, V. J., Pockaj, B. A., Mukherjee, P. & Gendler, S. J., Sep 1 2016, In : Biomolecules. 6, 3, 31.

Research output: Contribution to journalArticle

Glycosylation
T-cells
Cytotoxic T-Lymphocytes
Anchors
Antigens
6 Citations (Scopus)

A flow cytometry-based assay for procoagulant platelet polyphosphate

Labberton, L., Long, A. T., Gendler, S. J., Snozek, C. L., Stavrou, E. X., Nickel, K. F., Maas, C., Blankenberg, S., Hernandez, J. S. & Renné, T., 2016, (Accepted/In press) In : Cytometry Part B - Clinical Cytometry.

Research output: Contribution to journalArticle

Polyphosphates
Flow Cytometry
Blood Platelets
Thrombin Receptors
Purinergic P2 Receptors
19 Citations (Scopus)

Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1

Hickey, R., Mao, S. A., Glorioso, J., Elgilani, F., Amiot, B., Chen, H., Rinaldo, P., Marler, R. J., Jiang, H., DeGrado, T. R., Suksanpaisan, L., O'Connor, M. K., Freeman, B. L., Ibrahim, S. C., Peng, K-W., Harding, C. O., Ho, C. S., Grompe, M., Ikeda, Y. H., Lillegard, J. B. & 2 others, Russell, S. J. & Nyberg, S., Jul 27 2016, In : Science Translational Medicine. 8, 349, 349ra99.

Research output: Contribution to journalArticle

Tyrosinemias
Genetic Therapy
Swine
Hepatocytes
Liver
10 Citations (Scopus)

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Tolllike receptor agonists

Manrique, S. Z., Dominguez, A. L., Mirza, N., Spencer, C. D., Bradley, J. M., Finke, J. H., Lee, J. J., Pease, L. R., Gendler, S. J. & Cohen, P. A., 2016, In : Oncotarget. 7, 28, p. 42919-42942 24 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Immunity
Toll-Like Receptors
Neoplasms
T-Lymphocytes
10 Citations (Scopus)

Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2

Xia, L. X., Hua, W., Jin, Y., Tian, B. P., Qiu, Z. W., Zhang, C., Che, L. Q., Zhou, H. B., Wu, Y. F., Huang, H. Q., Lan, F., Ke, Y. H., Lee, J. J., Li, W., Ying, S. M., Chen, Z. H. & Shen, H. H., Apr 7 2016, In : Cell Death and Disease. 7, e2175.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Eosinophils
Bone Marrow
Respiratory Hypersensitivity
Inflammation
12 Citations (Scopus)

Eosinophil peroxidase catalyzed protein carbamylation participates in asthma

Wang, Z., DiDonato, J. A., Buffa, J., Comhair, S. A., Aronica, M. A., Dweik, R. A., Lee, N. A., Lee, J. J., Thomassen, M. J., Kavuru, M., Erzurum, S. C. & Hazen, S. L., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 22118-22135 18 p.

Research output: Contribution to journalArticle

Eosinophil Peroxidase
Asthma
Proteins
Eosinophils
Post Translational Protein Processing
9 Citations (Scopus)

EUS-guided portal injection chemotherapy for treatment of hepatic metastases: Feasibility in the acute porcine model

Faigel, D. O., Lake, D. F., Landreth, T. L., Kelman, C. C. & Marler, R. J., Feb 1 2016, In : Gastrointestinal Endoscopy. 83, 2, p. 444-446 3 p.

Research output: Contribution to journalArticle

irinotecan
Swine
Neoplasm Metastasis
Drug Therapy
Injections
17 Citations (Scopus)

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

Xu, Q., Hou, Y. X., Langlais, P. R., Erickson, P., Zhu, J., Shi, C. X., Luo, M., Zhu, Y., Xu, Y., Mandarino, L. J., Stewart, A. K. & Chang, X-B. D., May 3 2016, In : BMC Cancer. 16, 1, 297.

Research output: Contribution to journalArticle

Multiple Myeloma
Cell Survival
Carrier Proteins
Growth
MicroRNAs
23 Citations (Scopus)

Human and mouse eosinophils have antiviral activity against parainfluenza virus

Drake, M. G., Bivins-Smith, E. R., Proskocil, B. J., Nie, Z., Scott, G. D., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., Sep 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 3, p. 387-394 8 p.

Research output: Contribution to journalArticle

Paramyxoviridae Infections
Viruses
Eosinophils
Antiviral Agents
Nitric Oxide
26 Citations (Scopus)

IL-33 drives eosinophil infiltration and pathogenic type 2 helper T-cell immune responses leading to chronic experimental ileitis

De Salvo, C., Wang, X. M., Pastorelli, L., Mattioli, B., Omenetti, S., Buela, K. A., Chowdhry, S., Garg, R. R., Goodman, W. A., Rodriguez-Palacios, A., Smith, D. E., Abbott, D. W., Cominelli, F., Bamias, G., Xin, W., Lee, J. J., Vecchi, M. & Pizarro, T. T., Apr 1 2016, In : American Journal of Pathology. 186, 4, p. 885-898 14 p.

Research output: Contribution to journalArticle

Ileitis
Th2 Cells
Eosinophils
Inflammatory Bowel Diseases
Inflammation
8 Citations (Scopus)

Induction of airway allergic inflammation by hypothiocyanite via epithelial cells

Suzuki, S., Ogawa, M., Ohta, S., Nunomura, S., Nanri, Y., Shiraishi, H., Mitamura, Y., Yoshihara, T., Lee, J. J. & Izuhara, K., Dec 30 2016, In : Journal of Biological Chemistry. 291, 53, p. 27219-27227 9 p.

Research output: Contribution to journalArticle

Epithelial Cells
Inflammation
Cyclic AMP-Dependent Protein Kinases
Peroxidases
Peroxidase
13 Citations (Scopus)

Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury

Al-Bataineh, M. M., Kinlough, C. L., Poland, P. A., Pastor-Soler, N. M., Sutton, T. A., Mang, H. E., Bastacky, S. I., Gendler, S. J., Madsen, C. S., Singh, S., Monga, S. P. & Hughey, R. P., Mar 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 6, p. F569-F579

Research output: Contribution to journalArticle

Catenins
Reperfusion Injury
Hypoxia-Inducible Factor 1
Kidney
Knockout Mice
19 Citations (Scopus)

MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice

Lakshminarayanan, V., Supekar, N. T., Wei, J., McCurry, D. B., Dueck, A., Kosiorek, H. E., Trivedi, P. P., Bradley, J. M., Madsen, C. S., Pathangey, L. B., Hoelzinger, D. B., Wolfert, M. A., Boons, G. J., Cohen, P. A. & Gendler, S. J., Jan 1 2016, In : PLoS One. 11, 1, e0145920.

Research output: Contribution to journalArticle

Transgenic Mice
Tumors
Vaccines
genetically modified organisms
peptides
7 Citations (Scopus)

Potential sites of CFTR activation by tyrosine kinases

Billet, A., Jia, Y., Jensen, T. J., Hou, Y. X., Chang, X-B. D., Riordan, J. R. & Hanrahan, J. W., 2016, In : Channels (Austin, Tex.). 10, 3, p. 247-251 5 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Tyrosine
Phosphorylation
Chemical activation
Chloride Channels
6 Citations (Scopus)

Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway

Dhruv, H. D., Roos, A., Tomboc, P. J., Tuncali, S., Chavez, A., Mathews, I., Berens, M. E., Loftus, J. C. & Tran, N., Feb 1 2016, In : Journal of Neuro-Oncology. 126, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Survival
temozolomide
Glioma
Alzheimer Disease
9 Citations (Scopus)

SGEF is regulated via TWEAK/Fn14/NF-κB signaling and promotes survival by modulation of the DNA repair response to temozolomide

Fortin Ensign, S. P., Roos, A., Mathews, I. T., Dhruv, H. D., Tuncali, S., Sarkaria, J. N., Symons, M. H., Loftus, J. C., Berens, M. E. & Tran, N., Mar 1 2016, In : Molecular Cancer Research. 14, 3, p. 302-312 11 p.

Research output: Contribution to journalArticle

temozolomide
DNA Repair
Glioblastoma
Glioma
Therapeutics

Signaling modification by GPCR heteromer and its implication on X-linked nephrogenic diabetes insipidus

Ng, H. K. H., Harikumar, K. G., Miller, L. J. & Chow, B. K. C., Sep 1 2016, In : PLoS One. 11, 9, e0163086.

Research output: Contribution to journalArticle

diabetes insipidus
Nephrogenic Diabetes Insipidus
Medical problems
secretin
Secretin
4 Citations (Scopus)

Structure and function of Cross-class complexes of G Protein-Coupled secretin and angiotensin 1a receptors

Harikumar, K. G., Augustine, M. L., Lee, L. T. O., Chow, B. K. C. & Miller, L. J., Aug 12 2016, In : Journal of Biological Chemistry. 291, 33, p. 17332-17344 13 p.

Research output: Contribution to journalArticle

Angiotensin Receptors
Secretin
Angiotensins
GTP-Binding Proteins
Calcium
3 Citations (Scopus)

Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis

Mcnamee, E. N., Biette, K. A., Hammer, J., Harris, R., Miyazawa, H., Lee, J. J., Furuta, G. T. & Masterson, J. C., 2016, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Eosinophilic Esophagitis
Granulocyte-Macrophage Colony-Stimulating Factor
Eosinophils
Eosinophilia
Granulocyte-Macrophage Colony-Stimulating Factor Receptors