Biochemistry and Molecular Biology

Research Output

2006

Computational challenges for modeling and simulating biomacromolecular assemblies

Uberbacher, E., LoCascio, P., Passovets, S., Ghattyvenkatakrishna, P., Agarwal, P., Arnold, N., Bordner, A. & Gorin, A., Oct 1 2006, In : Journal of Physics: Conference Series. 46, 1, p. 311-315 5 p., 043.

Research output: Contribution to journalArticle

1 Scopus citations

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

Lipinski, C. A., Tran, N. L., Dooley, A., Pang, Y. P., Rohl, C., Kloss, J., Yang, Z., McDonough, W., Craig, D., Berens, M. E. & Loftus, J. C., Oct 27 2006, In : Biochemical and Biophysical Research Communications. 349, 3, p. 939-947 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Cutting edge: Enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice

Lu, W., Hisatsune, A., Koga, T., Kato, K., Kuwahara, I., Lillehoj, E. P., Chen, W., Cross, A. S., Gendler, S. J., Gewirtz, A. T. & Kim, K. C., Apr 1 2006, In : Journal of Immunology. 176, 7, p. 3890-3894 5 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis

Padigel, U. M., Lee, J. J., Nolan, T. J., Schad, G. A. & Abraham, D., Jun 1 2006, In : Infection and Immunity. 74, 6, p. 3232-3238 7 p.

Research output: Contribution to journalArticle

116 Scopus citations

Evidence That Gallbladder Epithelial Mucin Enhances Cholesterol Cholelithogenesis in MUC1 Transgenic Mice

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Jul 2006, In : Gastroenterology. 131, 1, p. 210-222 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive

Hegedus, T., Aleksandrov, A., Cui, L., Gentzsch, M., Chang, X. B. & Riordan, J. R., May 1 2006, In : Biochimica et Biophysica Acta - Biomembranes. 1758, 5, p. 565-572 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Fluorescence characteristics of hydrophobic partial agonist probes of the cholecystokinin receptor

Harikumar, K. G., Pinon, D. I. & Miller, L. J., Apr 1 2006, In : Bioscience reports. 26, 2, p. 89-100 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
19 Scopus citations

Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-κB and correlate with poor patient outcome

Tran, N. L., McDonough, W. S., Savitch, B. A., Fortin, S. P., Winkles, J. A., Symons, M., Nakada, M., Cunliffe, H. E., Hostetter, G., Hoelzinger, D. B., Rennert, J. L., Michaelson, J. S., Burkly, L. C., Lipinski, C. A., Loftus, J. C., Mariani, L. & Berens, M. E., Oct 1 2006, In : Cancer research. 66, 19, p. 9535-9542 8 p.

Research output: Contribution to journalArticle

138 Scopus citations

Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression

Malmberg, E. K., Noaksson, K. A., Phillipson, M., Johansson, M. E. V., Hinojosa-Kurtzberg, M., Holm, L., Gendler, S. J. & Hansson, G. C., Jul 14 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 2, p. G203-G210

Research output: Contribution to journalArticle

40 Scopus citations

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

Specht, S., Saeftel, M., Arndt, M., Endl, E., Dubben, B., Lee, N. A., Lee, J. J. & Hoerauf, A., Sep 1 2006, In : Infection and Immunity. 74, 9, p. 5236-5243 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

MUC1 alters oncogenic events and transcription in human breast cancer cells

Hattrup, C. L. & Gendler, S. J., Jul 17 2006, In : Breast Cancer Research. 8, 4, R37.

Research output: Contribution to journalArticle

65 Scopus citations

MUC1 cytoplasmic tail detection using CT33 polyclonal and CT2 monoclonal antibodies in breast and colorectal tissue

Croce, M. V., Isla-Larrain, M., Remes-Lenicov, F., Colussi, A. G., Lacunza, E., Kim, K. C., Gendler, S. J. & Segal-Eiras, A., Jul 1 2006, In : Histology and Histopathology. 21, 7-9, p. 849-855 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention

Gwinn, W. M., Damsker, J. M., Falahati, R., Okwumabua, I., Kelly-Welch, A., Keegan, A. D., Vanpouille, C., Lee, J. J., Dent, L. A., Leitenberg, D., Bukrinsky, M. I. & Constant, S. L., Oct 1 2006, In : Journal of Immunology. 177, 7, p. 4870-4879 10 p.

Research output: Contribution to journalArticle

Open Access
96 Scopus citations

Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response

Cormier, S. A., Taranova, A. G., Bedient, C., Nguyen, T., Protheroe, C., Pero, R., Dimina, D., Ochkur, S. I., O'Neill, K., Colbert, D., Lombari, T. R., Constant, S., McGarry, M. P., Lee, J. J. & Lee, N. A., Jun 1 2006, In : Journal of Leukocyte Biology. 79, 6, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

122 Scopus citations

Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation

Chan, R. C. F., Wang, M., Li, N., Yanagawa, Y., Onoé, K., Lee, J. J. & Nel, A. E., Aug 1 2006, In : Journal of Allergy and Clinical Immunology. 118, 2, p. 455-465 11 p.

Research output: Contribution to journalArticle

89 Scopus citations

Regulation of mucin genes in chronic inflammatory airway diseases

Voynow, J. A., Gendler, S. J. & Rose, M. C., Jun 1 2006, In : American journal of respiratory cell and molecular biology. 34, 6, p. 661-665 5 p.

Research output: Contribution to journalReview article

148 Scopus citations

Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis

Rådinger, M., Sergejeva, S., Johansson, A. K., Malmhäll, C., Bossios, A., Sjöstrand, M., Lee, J. J. & Lötvall, J., Jan 6 2006, In : Respiratory Research. 7, 83.

Research output: Contribution to journalArticle

9 Scopus citations

Replacement of the positively charged Walker A lysine residue with a hydrophobic leucine residue and conformational alterations caused by this mutation in MRP1 impair ATP binding and hydrolysis

Buyse, F., Hou, Y. X., Vigano, C., Zhao, Q., Ruysschaert, J. M. & Chang, X. B., Jul 1 2006, In : Biochemical Journal. 397, 1, p. 121-130 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval Strongyloides stercoralis in mice

Galioto, A. M., Hess, J. A., Nolan, T. J., Schad, G. A., Lee, J. J. & Abraham, D., Oct 1 2006, In : Infection and Immunity. 74, 10, p. 5730-5738 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Schistosoma mansoni infection in eosinophil lineage-ablated mice

Swartz, J. M., Dyer, K. D., Cheever, A. W., Ramalingam, T., Pesnicak, L., Domachowske, J. B., Lee, J. J., Lee, N. A., Foster, P. S., Wynn, T. A. & Rosenberg, H. F., Oct 1 2006, In : Blood. 108, 7, p. 2420-2427 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

Sodium iodide symporter-mediated radioiodide imaging and therapy of ovarian tumor xenografts in mice

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Jan 2006, In : Gene Therapy. 13, 1, p. 60-66 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J. E., Thompson, J. R., Chen, J. & Mer, G., Dec 29 2006, In : Cell. 127, 7, p. 1361-1373 13 p.

Research output: Contribution to journalArticle

658 Scopus citations

Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function

Harikumar, K. G., Dong, M., Cheng, Z., Pinon, D. I., Lybrand, T. P. & Miller, L. J., Dec 12 2006, In : Biochemistry. 45, 49, p. 14706-14716 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tyrosines in the MUC1 cytoplasmic tail modulate transcription via the extracellular signal-regulated kinase 1/2 and nuclear factor-κB pathways

Thompson, E. J., Shanmugam, K., Hattrup, C. L., Kotlarczyk, K. L., Gutierrez, A., Bradley, J. M., Mukherjee, P. & Gendler, S. J., Jul 1 2006, In : Molecular Cancer Research. 4, 7, p. 489-497 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
19 Scopus citations
2005

A downer Nubian goat with coughing

Gades, N. M., Okerman, R., Twernbold, D., Thompson, K., Bjertness, L. & Marler, R., Sep 1 2005, In : Lab Animal. 34, 8, p. 24-25 2 p.

Research output: Contribution to journalArticle

Analysis of the cellular and molecular mechanisms of trophic action of a misspliced form of the type B cholecystokinin receptor present in colon and pancreatic cancer

Cheng, Z. J., Harikumar, K. G., Ding, W. Q., Holicky, E. L. & Miller, L. J., May 10 2005, In : Cancer Letters. 222, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

A preclinical large animal model of adenovirus-mediated expression of the sodium-iodide symporter for radioiodide imaging and therapy of locally recurrent prostate cancer

Dwyer, R. M., Schatz, S. M., Bergert, E. R., Myers, R. M., Harvey, M. E., Classic, K. L., Blanco, M. C., Frisk, C. S., Marler, R. J., Davis, B. J., O'Connor, M. K., Russell, S. J. & Morris, J. C., Nov 2005, In : Molecular Therapy. 12, 5, p. 835-841 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Decreased size and survival of weanling mice in litters of IL-5 -/- mice are a consequence of the IL-5 deficiency in nursing dams

Colbert, D. C., McGarry, M. P., O'Neill, K., Lee, N. A. & Lee, J. J., May 1 2005, In : Contemporary Topics in Laboratory Animal Science. 44, 3, p. 53-55 3 p.

Research output: Contribution to journalArticle

13 Scopus citations

Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor

Harikumar, K. G., Puri, V., Singh, R. D., Hanada, K., Pagano, R. E. & Miller, L. J., Jan 21 2005, In : Journal of Biological Chemistry. 280, 3, p. 2176-2185 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopy

Harikumar, K. G., Clain, J., Pinon, D. I., Bong, M. & Miller, L. J., Jan 14 2005, In : Journal of Biological Chemistry. 280, 2, p. 1044-1050 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Eosinophil degranulation: An evolutionary vestige or a universally destructive effector function?

Lee, J. J. & Lee, N. A., Aug 1 2005, In : Clinical and Experimental Allergy. 35, 8, p. 986-994 9 p.

Research output: Contribution to journalReview article

79 Scopus citations

Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection

Ramalingam, T., Porte, P., Lee, J. & Rajan, T. V., Dec 1 2005, In : Infection and Immunity. 73, 12, p. 8442-8443 2 p.

Research output: Contribution to journalArticle

20 Scopus citations

Eosinophils alter colonic epithelial barrier function: Role for major basic protein

Furuta, G. T., Nieuwenhuis, E. E. S., Karhausen, J., Gleich, G., Blumberg, R. S., Lee, J. J. & Ackerman, S. J., Nov 1 2005, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 289, 5 52-5, p. G890-G897

Research output: Contribution to journalArticle

98 Scopus citations

Fluorescence resonance energy transfer analysis of the antagonist- and partial agonist-occupied states of the cholecystokinin receptor

Harikumar, K. G. & Miller, L. J., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 18631-18635 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Feb 15 2005, In : Clinical Cancer Research. 11, 4, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells.

Basu, G. D., Pathangey, L. B., Tinder, T. L., Gendler, S. J. & Mukherjee, P., 2005, In : Breast cancer research : BCR. 7, 4, p. R422-435

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells

Mukherjee, P., Tinder, T. L., Basu, G. D. & Gendler, S. J., Jan 1 2005, In : Journal of Leukocyte Biology. 77, 1, p. 90-99 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis

Al Masri, A. & Gendler, S. J., Sep 1 2005, In : Oncogene. 24, 38, p. 5799-5808 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nucleotide dissociation from NBD1 promotes solute transport by MRP1

Yang, R., McBride, A., Hou, Y. X., Goldberg, A. & Chang, X. B., Mar 1 2005, In : Biochimica et Biophysica Acta - Biomembranes. 1668, 2, p. 248-261 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression

Lindsay, T. H., Jonas, B. M., Sevcik, M. A., Kubota, K., Halvorson, K. G., Ghilardi, J. R., Kuskowski, M. A., Stelow, E. B., Mukherjee, P., Gendler, S. J., Wong, G. Y. & Mantyh, P. W., Dec 15 2005, In : Pain. 119, 1-3, p. 233-246 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

REVCOM: A robust Bayesian method for evolutionary rate estimation

Bordner, A. J. & Abagyan, R., May 15 2005, In : Bioinformatics. 21, 10, p. 2315-2321 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of cholesterol in ligand binding and G-protein coupling of serotonin1A receptors solubilized from bovine hippocampus

Chattopadhyay, A., Jafurulla, M., Kalipatnapu, S., Pucadyil, T. J. & Harikumar, K. G., Feb 25 2005, In : Biochemical and Biophysical Research Communications. 327, 4, p. 1036-1041 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Statistical analysis and prediction of protein-protein interfaces

Bordner, A. J. & Abagyan, R., Aug 15 2005, In : Proteins: Structure, Function and Genetics. 60, 3, p. 353-366 14 p.

Research output: Contribution to journalArticle

134 Scopus citations

Targeted measles virus vector displaying echistatin infects endothelial cells via αvβ3 and leads to tumor regression

Hallak, L. K., Merchan, J. R., Storgard, C. M., Loftus, J. C. & Russell, S. J., Jun 15 2005, In : Cancer research. 65, 12, p. 5292-5300 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

The tyrosine kinase Pyk2 promotes migration and invasion of glioma cells

Lipinski, C. A., Tran, N. L., Menashi, E., Rohl, C., Kloss, J., Bay, R. C., Berens, M. E. & Loftus, J. C., May 2005, In : Neoplasia. 7, 5, p. 435-445 11 p.

Research output: Contribution to journalArticle

102 Scopus citations

Tumor-associated carbohydrate antigens: A possible avenue for cancer prevention

Xu, Y., Sette, A., Sidney, J., Gendler, S. J. & Franco, A., Aug 1 2005, In : Immunology and Cell Biology. 83, 4, p. 440-448 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Validation of a mouse adhesion reduction model using Seprafilm®

Morse, A. N., Hammer, R. A., Cornella, J. L. & Loftus, J. C., Dec 1 2005, In : Journal of Gynecologic Surgery. 21, 4, p. 147-153 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2004

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Young, H. W. J., Molina, J. G., Dimina, D., Zhong, H., Jacobson, M., Chan, L. N. L., Chan, T. S., Lee, J. J. & Blackburn, M. R., Jul 15 2004, In : Journal of Immunology. 173, 2, p. 1380-1389 10 p.

Research output: Contribution to journalArticle

Open Access
111 Scopus citations