Biochemistry and Molecular Biology

Research Output

2006

Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-κB and correlate with poor patient outcome

Tran, N., McDonough, W. S., Savitch, B. A., Fortin, S. P., Winkles, J. A., Symons, M., Nakada, M., Cunliffe, H. E., Hostetter, G., Hoelzinger, D. B., Rennert, J. L., Michaelson, J. S., Burkly, L. C., Lipinski, C. A., Loftus, J. C., Mariani, L. & Berens, M. E., Oct 1 2006, In : Cancer Research. 66, 19, p. 9535-9542 8 p.

Research output: Contribution to journalArticle

138 Scopus citations

Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression

Malmberg, E. K., Noaksson, K. A., Phillipson, M., Johansson, M. E. V., Hinojosa-Kurtzberg, M., Holm, L., Gendler, S. J. & Hansson, G. C., 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 2

Research output: Contribution to journalArticle

40 Scopus citations

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

Specht, S., Saeftel, M., Arndt, M., Endl, E., Dubben, B., Lee, N. A., Lee, J. J. & Hoerauf, A., Sep 2006, In : Infection and Immunity. 74, 9, p. 5236-5243 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

MUC1 alters oncogenic events and transcription in human breast cancer cells

Hattrup, C. L. & Gendler, S. J., Jul 17 2006, In : Breast Cancer Research. 8, 4, R37.

Research output: Contribution to journalArticle

64 Scopus citations

MUC1 cytoplasmic tail detection using CT33 polyclonal and CT2 monoclonal antibodies in breast and colorectal tissue

Croce, M. V., Isla-Larrain, M., Remes-Lenicov, F., Colussi, A. G., Lacunza, E., Kim, K. C., Gendler, S. J. & Segal-Eiras, A., Jul 2006, In : Histology and Histopathology. 21, 7-9, p. 849-855 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Novel approach to inhibit asthma-mediated lung inflammation using Anti-CD147 intervention

Gwinn, W. M., Damsker, J. M., Falahati, R., Okwumabua, I., Kelly-Welch, A., Keegan, A. D., Vanpouille, C., Lee, J. J., Dent, L. A., Leitenberg, D., Bukrinsky, M. I. & Constant, S. L., Oct 1 2006, In : Journal of Immunology. 177, 7, p. 4870-4879 10 p.

Research output: Contribution to journalArticle

95 Scopus citations

Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response

Cormier, S. A., Taranova, A. G., Bedient, C., Nguyen, T., Protheroe, C., Pero, R., Dimina, D., Ochkur, S. I., O'Neill, K., Colbert, D., Lombari, T. R., Constant, S., McGarry, M. P., Lee, J. J. & Lee, N. A., Jun 2006, In : Journal of Leukocyte Biology. 79, 6, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

121 Scopus citations

Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation

Chan, R. C. F., Wang, M., Li, N., Yanagawa, Y., Onoé, K., Lee, J. J. & Nel, A. E., Aug 2006, In : Journal of Allergy and Clinical Immunology. 118, 2, p. 455-465 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis

Rådinger, M., Sergejeva, S., Johansson, A. K., Malmhäll, C., Bossios, A., Sjöstrand, M., Lee, J. J. & Lötvall, J., Jan 6 2006, In : Respiratory Research. 7, 83.

Research output: Contribution to journalArticle

9 Scopus citations

Replacement of the positively charged Walker A lysine residue with a hydrophobic leucine residue and conformational alterations caused by this mutation in MRP1 impair ATP binding and hydrolysis

Buyse, F., Hou, Y. X., Vigano, C., Zhao, Q., Ruysschaert, J. M. & Chang, X-B. D., Jul 1 2006, In : Biochemical Journal. 397, 1, p. 121-130 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval Strongyloides stercoralis in mice

Galioto, A. M., Hess, J. A., Nolan, T. J., Schad, G. A., Lee, J. J. & Abraham, D., Oct 2006, In : Infection and Immunity. 74, 10, p. 5730-5738 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Sodium iodide symporter-mediated radioiodide imaging and therapy of ovarian tumor xenografts in mice

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Jan 2006, In : Gene Therapy. 13, 1, p. 60-66 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J. E., Thompson, J. R., Chen, J. & Mer, G., Dec 29 2006, In : Cell. 127, 7, p. 1361-1373 13 p.

Research output: Contribution to journalArticle

646 Scopus citations

Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function

Harikumar, K. G., Dong, M., Cheng, Z., Pinon, D. I., Lybrand, T. P. & Miller, L. J., Dec 12 2006, In : Biochemistry. 45, 49, p. 14706-14716 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tyrosines in the MUC1 cytoplasmic tail modulate transcription via the extracellular signal-regulated kinase 1/2 and nuclear factor-κB pathways

Thompson, E. J., Shanmugam, K., Hattrup, C. L., Kotlarczyk, K. L., Gutierrez, A., Bradley, J. M., Mukherjee, P. & Gendler, S. J., Jul 2006, In : Molecular Cancer Research. 4, 7, p. 489-497 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
19 Scopus citations
2005

A downer Nubian goat with coughing

Gades, N. M., Okerman, R., Twernbold, D., Thompson, K., Bjertness, L. & Marler, R. J., Sep 2005, In : Lab Animal. 34, 8, p. 24-25 2 p.

Research output: Contribution to journalArticle

Analysis of the cellular and molecular mechanisms of trophic action of a misspliced form of the type B cholecystokinin receptor present in colon and pancreatic cancer

Cheng, Z. J., Harikumar, K. G., Ding, W. Q., Holicky, E. L. & Miller, L. J., May 10 2005, In : Cancer Letters. 222, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

A preclinical large animal model of adenovirus-mediated expression of the sodium-iodide symporter for radioiodide imaging and therapy of locally recurrent prostate cancer

Dwyer, R. M., Schatz, S. M., Bergert, E. R., Myers, R. M., Harvey, M. E., Classic, K. L., Blanco, M. C., Frisk, C. S., Marler, R. J., Davis, B. J., O'Connor, M. K., Russell, S. J. & Morris, J. C., Nov 2005, In : Molecular Therapy. 12, 5, p. 835-841 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Decreased size and survival of weanling mice in litters of IL-5 -/- mice are a consequence of the IL-5 deficiency in nursing dams

Colbert, D. C., McGarry, M. P., O'Neill, K., Lee, N. A. & Lee, J. J., May 2005, In : Contemporary Topics in Laboratory Animal Science. 44, 3, p. 53-55 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor

Harikumar, K. G., Puri, V., Singh, R. D., Hanada, K., Pagano, R. E. & Miller, L. J., Jan 21 2005, In : Journal of Biological Chemistry. 280, 3, p. 2176-2185 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopy

Harikumar, K. G., Clain, J., Pinon, D. I., Bong, M. & Miller, L. J., Jan 14 2005, In : Journal of Biological Chemistry. 280, 2, p. 1044-1050 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Eosinophil degranulation: An evolutionary vestige or a universally destructive effector function?

Lee, J. J. & Lee, N. A., Aug 2005, In : Clinical and Experimental Allergy. 35, 8, p. 986-994 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection

Ramalingam, T., Porte, P., Lee, J. & Rajan, T. V., Dec 2005, In : Infection and Immunity. 73, 12, p. 8442-8443 2 p.

Research output: Contribution to journalArticle

20 Scopus citations

Eosinophils alter colonic epithelial barrier function: Role for major basic protein

Furuta, G. T., Nieuwenhuis, E. E. S., Karhausen, J., Gleich, G., Blumberg, R. S., Lee, J. J. & Ackerman, S. J., Nov 2005, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 289, 5 52-5

Research output: Contribution to journalArticle

98 Scopus citations

Fluorescence resonance energy transfer analysis of the antagonist- and partial agonist-occupied states of the cholecystokinin receptor

Harikumar, K. G. & Miller, L. J., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 18631-18635 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Feb 15 2005, In : Clinical Cancer Research. 11, 4, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells.

Basu, G. D., Pathangey, L. B., Tinder, T. L., Gendler, S. J. & Mukherjee, P., 2005, In : Breast cancer research : BCR. 7, 4

Research output: Contribution to journalArticle

115 Scopus citations

MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells

Mukherjee, P., Tinder, T. L., Basu, G. D. & Gendler, S. J., Jan 2005, In : Journal of Leukocyte Biology. 77, 1, p. 90-99 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis

Al Masri, A. & Gendler, S. J., Sep 1 2005, In : Oncogene. 24, 38, p. 5799-5808 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nucleotide dissociation from NBD1 promotes solute transport by MRP1

Yang, R., McBride, A., Hou, Y. X., Goldberg, A. & Chang, X-B. D., Mar 1 2005, In : Biochimica et Biophysica Acta - Biomembranes. 1668, 2, p. 248-261 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression

Lindsay, T. H., Jonas, B. M., Sevcik, M. A., Kubota, K., Halvorson, K. G., Ghilardi, J. R., Kuskowski, M. A., Stelow, E. B., Mukherjee, P., Gendler, S. J., Wong, G. Y. & Mantyh, P. W., Dec 15 2005, In : Pain. 119, 1-3, p. 233-246 14 p.

Research output: Contribution to journalArticle

71 Scopus citations

Targeted measles virus vector displaying echistatin infects endothelial cells via αvβ3 and leads to tumor regression

Hallak, L. K., Merchan, J. R., Storgard, C. M., Loftus, J. C. & Russell, S. J., Jun 15 2005, In : Cancer Research. 65, 12, p. 5292-5300 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

The tyrosine kinase Pyk2 promotes migration and invasion of glioma cells

Lipinski, C. A., Tran, N., Menashi, E., Rohl, C., Kloss, J., Bay, R. C., Berens, M. E. & Loftus, J. C., May 2005, In : Neoplasia. 7, 5, p. 435-445 11 p.

Research output: Contribution to journalArticle

100 Scopus citations

Tumor-associated carbohydrate antigens: A possible avenue for cancer prevention

Xu, Y., Sette, A., Sidney, J., Gendler, S. J. & Franco, A., Aug 2005, In : Immunology and Cell Biology. 83, 4, p. 440-448 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Validation of a mouse adhesion reduction model using Seprafilm®

Morse, A. N., Hammer, R. A., Cornella, J. L. & Loftus, J. C., Dec 2005, In : Journal of Gynecologic Surgery. 21, 4, p. 147-153 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2004

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Young, H. W. J., Molina, J. G., Dimina, D., Zhong, H., Jacobson, M., Chan, L. N. L., Chan, T. S., Lee, J. J. & Blackburn, M. R., Jul 15 2004, In : Journal of Immunology. 173, 2, p. 1380-1389 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

Allergen-induced traffic of bone marrow eosinophils, neutrophils and lymphocytes to airways

Johansson, A. K., Sergejeva, S., Sjöstrand, M., Lee, J. J. & Lötvall, J., Nov 2004, In : European Journal of Immunology. 34, 11, p. 3135-3145 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer

Basu, G. D., Pathangey, L. B., Tinder, T. L., LaGioia, M., Gendler, S. J. & Mukherjee, P., Nov 2004, In : Molecular Cancer Research. 2, 11, p. 632-642 11 p.

Research output: Contribution to journalArticle

128 Scopus citations

Defining a link with asthma in mice congenitally deficient in eosinophils

Lee, J. J., Dimina, D., Macias, M. P., Ochkur, S. I., McGarry, M. P., O'Neill, K. R., Protheroe, C., Pero, R., Nguyen, T., Cormier, S. A., Lenkiewicz, E., Colbert, D., Rinaldi, L., Ackerman, S. J., Irvin, C. G. & Lee, N. A., Sep 17 2004, In : Science. 305, 5691, p. 1773-1776 4 p.

Research output: Contribution to journalArticle

547 Scopus citations

Designer Glycopeptides for Cytotoxic T Cell-based Elimination of Carcinomas

Xu, Y., Gendler, S. J. & Franco, A., Mar 1 2004, In : Journal of Experimental Medicine. 199, 5, p. 707-716 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Downregulation of Muc1 in MMTV-c-Neu tumors

Adriance, M. C. & Gendler, S. J., Jan 22 2004, In : Oncogene. 23, 3, p. 697-705 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of raloxifene hydrochloride on endometrial cancer cells in vitro

Hibner, M., Magrina, J. F., Lefler, S. R., Cornella, J. L., Pizarro, A. R. & Loftus, J. C., Jun 2004, In : Gynecologic Oncology. 93, 3, p. 642-646 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endocytic trafficking routes of wild type and ΔF508 cystic fibrosis transmembrane conductance regulator

Gentzsch, M., Chang, X-B. D., Cui, L., Wu, Y., Ozols, V. V., Choudhury, A., Pagano, R. E. & Riordan, J. R., Jun 2004, In : Molecular Biology of the Cell. 15, 6, p. 2684-2696 13 p.

Research output: Contribution to journalArticle

166 Scopus citations

Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen

Clark, K., Simson, L., Newcombe, N., Koskinen, A. M. L., Mattes, J., Lee, N. A., Lee, J. J., Dent, L. A., Matthaei, K. I. & Foster, P. S., Jun 2004, In : Journal of Leukocyte Biology. 75, 6, p. 1001-1009 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Fluorescent modified phosphatidylcholine floppase activity of reconstituted multidrug resistance-associated protein MRP1

Huang, Z., Chang, X-B. D., Riordan, J. R. & Huang, Y., Jan 28 2004, In : Biochimica et Biophysica Acta - Biomembranes. 1660, 1, p. 155-163 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: Role for tethered mucins as barriers to lumenal infection

Stonebraker, J. R., Wagner, D., Lefensty, R. W., Burns, K., Gendler, S. J., Bergelson, J. M., Boucher, R. C., O'Neal, W. K. & Pickles, R. J., Dec 2004, In : Journal of Virology. 78, 24, p. 13755-13768 14 p.

Research output: Contribution to journalArticle

58 Scopus citations

G-protein-dependent cell surface dynamics of the human serotonin 1A receptor tagged to yellow fluorescent protein

Pucadyil, T. J., Kalipatnapu, S., Harikumar, K. G., Rangaraj, N., Karnik, S. S. & Chattopadhyay, A., Dec 21 2004, In : Biochemistry. 43, 50, p. 15852-15862 11 p.

Research output: Contribution to journalArticle

57 Scopus citations

Immunoglobulin E and Eosinophil-Dependent Protective Immunity to Larval Onchocerca volvulus in Mice Immunized with Irradiated Larvae

Abraham, D., Leon, O., Schnyder-Candrian, S., Wang, C. C., Galioto, A. M., Kerepesi, L. A., Lee, J. J. & Lustigman, S., Feb 2004, In : Infection and Immunity. 72, 2, p. 810-817 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Immunopathogenesis of Experimental Ulcerative Colitis is Mediated by Eosinophil Peroxidase

Forbes, E., Murase, T., Yang, M., Matthaei, K. I., Lee, J. J., Lee, N. A., Foster, P. S. & Hogan, S. P., May 1 2004, In : Journal of Immunology. 172, 9, p. 5664-5675 12 p.

Research output: Contribution to journalArticle

126 Scopus citations