Biochemistry and Molecular Biology

2013

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor

Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B. R., Abagyan, R., Christopoulos, A., Sexton, P. M. & Miller, L. J., Jul 19 2013, In: Journal of Biological Chemistry. 288, 29, p. 21082-21095 14 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

New insights into the functional consequences of ephrin A3 mutations in non-small cell lung cancer

Whitsett, T. G., Loftus, J. C., Winkles, J. A. & Tran, N. L., 2013, In: Translational Lung Cancer Research. 2, 1, p. 3-5 3 p.

Research output: Contribution to journal › Editorial › peer-review

1 Scopus citations

Reciprocal Activation of Transcription Factors Underlies the Dichotomy between Proliferation and Invasion of Glioma Cells

Dhruv, H. D., McDonough Winslow, W. S., Armstrong, B., Tuncali, S., Eschbacher, J., Kislin, K., Loftus, J. C., Tran, N. L. & Berens, M. E., Aug 15 2013, In: PloS one. 8, 8, e72134.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis

Dhruv, H., Loftus, J. C., Narang, P., Petit, J. L., Fameree, M., Burton, J., Tchegho, G., Chow, D., Yin, H., Al-Abed, Y., Berens, M. E., Tran, N. L. & Meurice, N., Nov 8 2013, In: Journal of Biological Chemistry. 288, 45, p. 32261-32276 16 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

Ke, J., Harikumar, K. G., Erice, C., Chen, C., Gu, X., Wang, L., Parker, N., Cheng, Z., Xu, W., Williams, B. O., Melcher, K., Miller, L. J. & Eric Xu, H., Nov 1 2013, In: Genes and Development. 27, 21, p. 2305-2319 15 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Structure-based prediction of major histocompatibility complex (MHC) epitopes

Bordner, A. J., 2013, Immunoproteomics: Methods and Protocols. Fulton, K. & Twine, S. (eds.). p. 323-343 21 p. (Methods in Molecular Biology; vol. 1061).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model

Ghosh, S. K., Uchida, M., Yoo, B., Ross, A. W., Gendler, S. J., Gong, J., Moore, A. & Medarova, Z., Apr 15 2013, In: International Journal of Cancer. 132, 8, p. 1860-1867 8 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

The consequences of not having eosinophils

Gleich, G. J., Klion, A. D., Lee, J. J. & Weller, P. F., Jul 2013, In: Allergy: European Journal of Allergy and Clinical Immunology. 68, 7, p. 829-835 7 p.

Research output: Contribution to journal › Review article › peer-review

85 Scopus citations

The oesophageal string test: A novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis

Furuta, G. T., Kagalwalla, A. F., Lee, J. J., Alumkal, P., Maybruck, B. T., Fillon, S., Masterson, J. C., Ochkur, S., Protheroe, C., Moore, W., Pan, Z., Amsden, K., Robinson, Z., Capocelli, K., Mukkada, V., Atkins, D., Fleischer, D., Hosford, L., Kwatia, M. A., Schroeder, S. & 4 others, Kelly, C., Lovell, M., Melin-Aldana, H. & Ackerman, S. J., Oct 2013, In: Gut. 62, 10, p. 1395-1405 11 p.

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2

Ensign, S. P. F., Mathews, I. T., Eschbacher, J. M., Loftus, J. C., Symons, M. H. & Tran, N. L., Jul 26 2013, In: Journal of Biological Chemistry. 288, 30, p. 21887-21897 11 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance

Loftus, J. C., Dhruv, H., Tuncali, S., Kloss, J., Yang, Z., Schumacher, C. A., Cao, B., Williams, B. O., Eschbacher, J. M., Ross, J. T. D. & Tran, N. L., Aug 2013, In: Molecular Cancer Research. 11, 8, p. 865-874 10 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

2012

A sensitive high throughput ELISA for human eosinophil peroxidase: A specific assay to quantify eosinophil degranulation from patient-derived sources

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Condjella, R. M., Bersoux, S., Helmers, R. A., Moqbel, R., Lacy, P., Kelly, E. A., Jarjour, N. N., Kern, R., Peters, A., Schleimer, R. P., Furuta, G. T., Nair, P., Lee, J. J. & Lee, N. A., Oct 31 2012, In: Journal of Immunological Methods. 384, 1-2, p. 10-20 11 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Assessing the accuracy of SAPT(DFT) interaction energies by comparison with experimentally derived noble gas potentials and molecular crystal lattice energies

Bordner, A. J., Dec 7 2012, In: ChemPhysChem. 13, 17, p. 3981-3988 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Fortin, S. P., Ennis, M. J., Schumacher, C. A., Zylstra-Diegel, C. R., Williams, B. O., Ross, J. T. D., Winkles, J. A., Loftus, J. C., Symons, M. H. & Tran, N. L., Jul 2012, In: Molecular Cancer Research. 10, 7, p. 958-968 11 p.

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Detection of Progressive Myocardial Tissue Injury by Ultrasonic Integrated Backscatter Immediately After Coronary Reperfusion

Katayama, M., Jiamsripong, P., McMahon, E. M., Lombari, T. R., Bukatina, A. E., Wu, Q., Marler, R. J. & Belohlavek, M., Sep 2012, In: Ultrasound in Medicine and Biology. 38, 9, p. 1662-1669 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

Potter, R. M., Harikumar, K. G., Wu, S. V. & Miller, L. J., Jan 2012, In: Journal of Lipid Research. 53, 1, p. 137-148 12 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion

Whitsett, T. G., Cheng, E., Inge, L., Asrani, K., Jameson, N. M., Hostetter, G., Weiss, G. J., Kingsley, C. B., Loftus, J. C., Bremner, R., Tran, N. L. & Winkles, J. A., Jul 2012, In: American Journal of Pathology. 181, 1, p. 111-120 10 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

Kagalwalla, A. F., Akhtar, N., Woodruff, S. A., Rea, B. A., Masterson, J. C., Mukkada, V., Parashette, K. R., Du, J., Fillon, S., Protheroe, C. A., Lee, J. J., Amsden, K., Melin-Aldana, H., Capocelli, K. E., Furuta, G. T. & Ackerman, S. J., May 2012, In: Journal of Allergy and Clinical Immunology. 129, 5, p. 1387-1396.e6

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Eosinophils preserve parasitic nematode larvae by regulating local immunity

Gebreselassie, N. G., Moorhead, A. R., Fabre, V., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2012, In: Journal of Immunology. 188, 1, p. 417-425 9 p.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

Hiddinga, H. J., Sakagashira, S., Ishigame, M., Madde, P., Sanke, T., Nanjo, K., Kudva, Y. C., Lee, J. J., van Deursen, J. & Eberhardt, N. L., Apr 2012, In: Journal of Diabetes Investigation. 3, 2, p. 138-147 10 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Force fields for homology modeling

Bordner, A. J., Mar 16 2012, Homology Modeling: Methods and Protocols. Orry, A. & Abagyan, R. (eds.). p. 83-106 24 p. (Methods in Molecular Biology; vol. 857).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, K. G., Wootten, D., Pinon, D. I., Koole, C., Ball, A. M., Furness, S. G. B., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. & Sexton, P. M., Nov 6 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18607-18612 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Human breast cancer stem cells have significantly higher rate of clathrin-independent and caveolin-independent endocytosis than the differentiated breast cancer cells

Palaniyandi, K., Pockaj, B. A., Gendler, S. J. & Chang, X. B., 2012, In: Journal of Cancer Science and Therapy. 4, 7, p. 214-222 9 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Human versus mouse eosinophils: "That which we call an eosinophil, by any other name would stain as red"

Lee, J. J., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Condjella, R. M., Doyle, A. D., Luo, H., Zellner, K. R., Protheroe, C. A., Willetts, L., Lesuer, W. E., Colbert, D. C., Helmers, R. A., Lacy, P., Moqbel, R. & Lee, N. A., Sep 2012, In: Journal of Allergy and Clinical Immunology. 130, 3, p. 572-584 13 p.

Research output: Contribution to journal › Review article › peer-review

113 Scopus citations

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

Lakshminarayanan, V., Thompson, P., Wolfert, M. A., Buskas, T., Bradley, J. M., Pathangey, L. B., Madsen, C. S., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 3 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 261-266 6 p.

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Interleukin 5 is protective during sepsis in an eosinophil-independent manner

Linch, S. N., Danielson, E. T., Kelly, A. M., Tamakawa, R. A., Lee, J. J. & Gold, J. A., Aug 1 2012, In: American journal of respiratory and critical care medicine. 186, 3, p. 246-254 9 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Intratumoral delivery of CpG-conjugated anti-MUC1 antibody enhances NK cell anti-tumor activity

Schettini, J., Kidiyoor, A., Besmer, D. M., Tinder, T. L., Roy, L. D., Lustgarten, J., Gendler, S. J. & Mukherjee, P., Nov 2012, In: Cancer Immunology, Immunotherapy. 61, 11, p. 2055-2065 11 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor

Miller, L. J., Dong, M. & Harikumar, K. G., May 2012, In: British Journal of Pharmacology. 166, 1, p. 18-26 9 p.

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity

Cawston, E. E., Harikumar, K. G. & Miller, L. J., Feb 2012, In: American Journal of Physiology - Cell Physiology. 302, 3, p. C615-C627

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

MiRNA expression profiling in migrating Glioblastoma cells: Regulation of cell migration and invasion by miR-23b via targeting of Pyk2

Loftus, J. C., Ross, J. T. D., Paquette, K. M., Paulino, V. M., Nasser, S., Yang, Z., Kloss, J., Kim, S., Berens, M. E. & Tran, N. L., Jun 22 2012, In: PloS one. 7, 6, e39818.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Modulation of β-catenin signaling by glucagon receptor activation

Ke, J., Zhang, C., Harikumar, K. G., Zylstra-Diegel, C. R., Wang, L., Mowry, L. E., Miller, L. J., Williams, B. O. & Xu, H. E., Mar 16 2012, In: PloS one. 7, 3, e33676.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor

Cawston, E. E., Lam, P. C. H., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., Akgün, E., Portoghese, P. S., Orry, A., Abagyan, R., Sexton, P. M. & Miller, L. J., May 25 2012, In: Journal of Biological Chemistry. 287, 22, p. 18618-18635 18 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

MUC1 regulates PDGFA expression during pancreatic cancer progression

Sahraei, M., Roy, L. D., Curry, J. M., Teresa, T. L., Nath, S., Besmer, D., Kidiyoor, A., Dalia, R., Gendler, S. J. & Mukherjee, P., Nov 22 2012, In: Oncogene. 31, 47, p. 4935-4945 11 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Myeloid-derived suppressor cells adhere to physiologic STAT3-vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape

Cohen, P. A., Ko, J. S., Storkus, W. J., Spencer, C. D., Bradley, J. M., Gorman, J. E., McCurry, D. B., Zorro-Manrique, S., Dominguez, A. L., Pathangey, L. B., Rayman, P. A., Rini, B. I., Gendler, S. J. & Finke, J. H., Aug 2012, In: Immunological Investigations. 41, 6-7, p. 680-710 31 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53

Cui, G., Park, S., Badeaux, A. I., Kim, D., Lee, J., Thompson, J. R., Yan, F., Kaneko, S., Yuan, Z., Botuyan, M. V., Bedford, M. T., Cheng, J. Q. & Mer, G., Sep 2012, In: Nature Structural and Molecular Biology. 19, 9, p. 916-924 9 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Placental protein 13 and decidual zones of necrosis: An immunologic diversion that may be linked to preeclampsia

Kliman, H. J., Sammar, M., Grimpel, Y. I., Lynch, S. K., Milano, K. M., Pick, E., Bejar, J., Arad, A., Lee, J. J., Meiri, H. & Gonen, R., Jan 2012, In: Reproductive Sciences. 19, 1, p. 16-30 15 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Predicting the effects of amino acid replacements in peptide hormones on their binding affinities for class B GPCRs and application to the design of secretin receptor antagonists

Te, J. A., Dong, M., Miller, L. J. & Bordner, A. J., Jul 2012, In: Journal of Computer-Aided Molecular Design. 26, 7, p. 835-845 11 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice

Qin, X. J., Zhang, G. S., Zhang, X., Qiu, Z. W., Wang, P. L., Li, Y. W., Li, W., Xie, Q. M., Ke, Y. H., Lee, J. J. & Shen, H. H., Dec 2012, In: Allergy: European Journal of Allergy and Clinical Immunology. 67, 12, p. 1547-1556 10 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

The construction of transgenic and gene knockout/knockin mouse models of human disease

Doyle, A., McGarry, M. P., Lee, N. A. & Lee, J. J., Apr 2012, In: Transgenic Research. 21, 2, p. 327-349 23 p.

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: Assessment of eosinophil degranulation ex vivo and in models of human disease

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Moqbel, R., Lacy, P., Lee, J. J. & Lee, N. A., Jan 31 2012, In: Journal of Immunological Methods. 375, 1-2, p. 138-147 10 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

The expanding role(s) of eosinophils in health and disease

Jacobsen, E. A., Helmers, R. A., Lee, J. J. & Lee, N. A., Nov 8 2012, In: Blood. 120, 19, p. 3882-3890 9 p.

Research output: Contribution to journal › Review article › peer-review

124 Scopus citations

Workshop report from the national institutes of health taskforce on the research needs of eosinophil-associated diseases (TREAD)

Bochner, B. S., Book, W., Busse, W. W., Butterfield, J., Furuta, G. T., Gleich, G. J., Klion, A. D., Lee, J. J., Leiferman, K. M., Minnicozzi, M., Moqbel, R., Rothenberg, M. E., Schwartz, L. B., Simon, H. U., Wechsler, M. E. & Weller, P. F., Sep 2012, In: Journal of Allergy and Clinical Immunology. 130, 3, p. 587-596 10 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

2011

CCR3 blockade attenuates eosinophilic ileitis and associated remodeling

Masterson, J. C., McNamee, E. N., Jedlicka, P., Fillon, S., Ruybal, J., Hosford, L., Rivera-Nieves, J., Lee, J. J. & Furuta, G. T., Nov 2011, In: American Journal of Pathology. 179, 5, p. 2302-2314 13 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

Zhu, Y. X., Braggio, E., Shi, C. X., Bruins, L. A., Schmidt, J. E., Van Wier, S., Chang, X. B., Bjorklund, C. C., Fonseca, R., Bergsagel, P. L., Orlowski, R. Z. & Stewart, A. K., Nov 3 2011, In: Blood. 118, 18, p. 4771-4779 9 p.

Research output: Contribution to journal › Article › peer-review

411 Scopus citations

Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal

Kinlough, C. L., Poland, P. A., Gendler, S. J., Mattila, P. E., Mo, D., Weisz, O. A. & Hughey, R. P., Nov 11 2011, In: Journal of Biological Chemistry. 286, 45, p. 39072-39081 10 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Efficient molecular mechanics simulations of the folding, orientation, and assembly of peptides in lipid bilayers using an implicit atomic solvation model

Bordner, A. J., Zorman, B. & Abagyan, R., Oct 2011, In: Journal of Computer-Aided Molecular Design. 25, 10, p. 895-911 17 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Eosinophilic oesophagitis in adults - A rising epidemic

Pasha, S. F., Crowell, M. D., Alexander, J. A., Harris, L. A., Achem, S. R., Farrugia, G., Lee, J. J., Thompson, D. M., Jung, K. W., Kita, H., Ravi, K., Namasivayam, V., Kim, H. J., Fleischer, D. E., Sharma, V. K. & Romero, Y., Feb 2011, In: European Gastroenterology and Hepatology Review. 7, 1, p. 14-20 7 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Eosinophils

Lee, N. A., Dahl, M. V., Jacobsen, E. A. & Ochkur, S. I., Jul 27 2011, Inflammation and Allergy Drug Design. Wiley-Blackwell, p. 107-121 15 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension

Weng, M., Baron, D. M., Bloch, K. D., Luster, A. D., Lee, J. J. & Medoff, B. D., Dec 2011, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 6, p. L927-L936

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Eosinophils are required for the maintenance of plasma cells in the bone marrow

Chu, V. T., Fröhlich, A., Steinhauser, G., Scheel, T., Roch, T., Fillatreau, S., Lee, J. J., Löhning, M. & Berek, C., Feb 2011, In: Nature immunology. 12, 2, p. 151-159 9 p.

Research output: Contribution to journal › Article › peer-review

344 Scopus citations

Biochemistry and Molecular Biology

Research output

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