Biochemistry and Molecular Biology

Research Output

2012

Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor

Miller, L. J., Dong, M. & Harikumar, K. G., May 1 2012, In : British Journal of Pharmacology. 166, 1, p. 18-26 9 p.

Research output: Contribution to journalReview article

11 Scopus citations

Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity

Cawston, E. E., Harikumar, K. G. & Miller, L. J., Feb 1 2012, In : American Journal of Physiology - Cell Physiology. 302, 3, p. C615-C627

Research output: Contribution to journalArticle

2 Scopus citations

MiRNA expression profiling in migrating Glioblastoma cells: Regulation of cell migration and invasion by miR-23b via targeting of Pyk2

Loftus, J. C., Ross, J. T. D., Paquette, K. M., Paulino, V. M., Nasser, S., Yang, Z., Kloss, J., Kim, S., Berens, M. E. & Tran, N. L., Jun 22 2012, In : PloS one. 7, 6, e39818.

Research output: Contribution to journalArticle

49 Scopus citations

Modulation of β-catenin signaling by glucagon receptor activation

Ke, J., Zhang, C., Harikumar, K. G., Zylstra-Diegel, C. R., Wang, L., Mowry, L. E., Miller, L. J., Williams, B. O. & Xu, H. E., Mar 16 2012, In : PloS one. 7, 3, e33676.

Research output: Contribution to journalArticle

13 Scopus citations

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor

Cawston, E. E., Lam, P. C. H., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., Akgün, E., Portoghese, P. S., Orry, A., Abagyan, R., Sexton, P. M. & Miller, L. J., May 25 2012, In : Journal of Biological Chemistry. 287, 22, p. 18618-18635 18 p.

Research output: Contribution to journalArticle

14 Scopus citations

MUC1 regulates PDGFA expression during pancreatic cancer progression

Sahraei, M., Roy, L. D., Curry, J. M., Teresa, T. L., Nath, S., Besmer, D., Kidiyoor, A., Dalia, R., Gendler, S. J. & Mukherjee, P., Nov 22 2012, In : Oncogene. 31, 47, p. 4935-4945 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Myeloid-derived suppressor cells adhere to physiologic STAT3-vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape

Cohen, P. A., Ko, J. S., Storkus, W. J., Spencer, C. D., Bradley, J. M., Gorman, J. E., McCurry, D. B., Zorro-Manrique, S., Dominguez, A. L., Pathangey, L. B., Rayman, P. A., Rini, B. I., Gendler, S. J. & Finke, J. H., Aug 1 2012, In : Immunological Investigations. 41, 6-7, p. 680-710 31 p.

Research output: Contribution to journalArticle

29 Scopus citations

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53

Cui, G., Park, S., Badeaux, A. I., Kim, D., Lee, J., Thompson, J. R., Yan, F., Kaneko, S., Yuan, Z., Botuyan, M. V., Bedford, M. T., Cheng, J. Q. & Mer, G., Sep 1 2012, In : Nature Structural and Molecular Biology. 19, 9, p. 916-924 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Placental protein 13 and decidual zones of necrosis: An immunologic diversion that may be linked to preeclampsia

Kliman, H. J., Sammar, M., Grimpel, Y. I., Lynch, S. K., Milano, K. M., Pick, E., Bejar, J., Arad, A., Lee, J. J., Meiri, H. & Gonen, R., Jan 1 2012, In : Reproductive Sciences. 19, 1, p. 16-30 15 p.

Research output: Contribution to journalArticle

46 Scopus citations
3 Scopus citations

Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice

Qin, X. J., Zhang, G. S., Zhang, X., Qiu, Z. W., Wang, P. L., Li, Y. W., Li, W., Xie, Q. M., Ke, Y. H., Lee, J. J. & Shen, H. H., Dec 1 2012, In : Allergy: European Journal of Allergy and Clinical Immunology. 67, 12, p. 1547-1556 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

The construction of transgenic and gene knockout/knockin mouse models of human disease

Doyle, A., McGarry, M. P., Lee, N. A. & Lee, J. J., Apr 1 2012, In : Transgenic Research. 21, 2, p. 327-349 23 p.

Research output: Contribution to journalReview article

89 Scopus citations

The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: Assessment of eosinophil degranulation ex vivo and in models of human disease

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Moqbel, R., Lacy, P., Lee, J. J. & Lee, N. A., Jan 31 2012, In : Journal of Immunological Methods. 375, 1-2, p. 138-147 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

The expanding role(s) of eosinophils in health and disease

Jacobsen, E. A., Helmers, R. A., Lee, J. J. & Lee, N. A., Nov 8 2012, In : Blood. 120, 19, p. 3882-3890 9 p.

Research output: Contribution to journalReview article

103 Scopus citations

Workshop report from the national institutes of health taskforce on the research needs of eosinophil-associated diseases (TREAD)

Bochner, B. S., Book, W., Busse, W. W., Butterfield, J., Furuta, G. T., Gleich, G. J., Klion, A. D., Lee, J. J., Leiferman, K. M., Minnicozzi, M., Moqbel, R., Rothenberg, M. E., Schwartz, L. B., Simon, H. U., Wechsler, M. E. & Weller, P. F., Sep 1 2012, In : Journal of Allergy and Clinical Immunology. 130, 3, p. 587-596 10 p.

Research output: Contribution to journalArticle

36 Scopus citations
2011

CCR3 blockade attenuates eosinophilic ileitis and associated remodeling

Masterson, J. C., McNamee, E. N., Jedlicka, P., Fillon, S., Ruybal, J., Hosford, L., Rivera-Nieves, J., Lee, J. J. & Furuta, G. T., Nov 1 2011, In : American Journal of Pathology. 179, 5, p. 2302-2314 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

Zhu, Y. X., Braggio, E., Shi, C. X., Bruins, L. A., Schmidt, J. E., Van Wier, S., Chang, X. B., Bjorklund, C. C., Fonseca, R., Bergsagel, P. L., Orlowski, R. Z. & Stewart, A. K., Nov 3 2011, In : Blood. 118, 18, p. 4771-4779 9 p.

Research output: Contribution to journalArticle

367 Scopus citations

Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal

Kinlough, C. L., Poland, P. A., Gendler, S. J., Mattila, P. E., Mo, D., Weisz, O. A. & Hughey, R. P., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39072-39081 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Efficient molecular mechanics simulations of the folding, orientation, and assembly of peptides in lipid bilayers using an implicit atomic solvation model

Bordner, A. J., Zorman, B. & Abagyan, R., Oct 1 2011, In : Journal of Computer-Aided Molecular Design. 25, 10, p. 895-911 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Eosinophilic oesophagitis in adults - A rising epidemic

Pasha, S. F., Crowell, M. D., Alexander, J. A., Harris, L. A., Achem, S. R., Farrugia, G., Lee, J. J., Thompson, D. M., Jung, K. W., Kita, H., Ravi, K., Namasivayam, V., Kim, H. J., Fleischer, D. E., Sharma, V. K. & Romero, Y., Feb 2011, In : European Gastroenterology and Hepatology Review. 7, 1, p. 14-20 7 p.

Research output: Contribution to journalReview article

1 Scopus citations

Eosinophils

Lee, N. A., Dahl, M. V., Jacobsen, E. A. & Ochkur, S. I., Jul 27 2011, Inflammation and Allergy Drug Design. Wiley-Blackwell, p. 107-121 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension

Weng, M., Baron, D. M., Bloch, K. D., Luster, A. D., Lee, J. J. & Medoff, B. D., Dec 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 6, p. L927-L936

Research output: Contribution to journalArticle

21 Scopus citations

Eosinophils are required for the maintenance of plasma cells in the bone marrow

Chu, V. T., Fröhlich, A., Steinhauser, G., Scheel, T., Roch, T., Fillatreau, S., Lee, J. J., Löhning, M. & Berek, C., Feb 1 2011, In : Nature immunology. 12, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

300 Scopus citations

Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, E. L., Simpson, E. L., Fredrikson, L. J., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., Jul 27 2011, In : PloS one. 6, 7, e22029.

Research output: Contribution to journalArticle

48 Scopus citations

Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation

Jacobsen, E. A., Zellner, K. R., Colbert, D., Lee, N. A. & Lee, J. J., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 6059-6068 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Fluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor

Harikumar, K. G., Cawston, E. E. & Miller, L. J., Aug 1 2011, In : Assay and Drug Development Technologies. 9, 4, p. 394-402 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor

Yang, R., Hou, Y. X., Campbell, C. A., Palaniyandi, K., Zhao, Q., Bordner, A. J. & Chang, X. B., Jul 1 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 7, p. 1790-1796 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury

Willetts, L., Parker, K., Wesselius, L. J., Protheroe, C. A., Jaben, E., Graziano, P., Moqbel, R., Leslie, K. O., Lee, N. A. & Lee, J. J., Aug 26 2011, In : Respiratory Research. 12, 116.

Research output: Contribution to journalArticle

18 Scopus citations

Importance and regulation of the colonic mucus barrier in a mouse model of colitis

Petersson, J., Schreiber, O., Hansson, G. C., Gendler, S. J., Velcich, A., Lundberg, J. O., Roos, S., Holm, L. & Phillipson, M., Feb 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 2, p. G327-G333

Research output: Contribution to journalArticle

178 Scopus citations

Importance of each residue within secretin for receptor binding and biological activity

Dong, M., Le, A., Te, J. A., Pinon, D. I., Bordner, A. J. & Miller, L. J., Apr 12 2011, In : Biochemistry. 50, 14, p. 2983-2993 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
6 Scopus citations

Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist

Dong, M., Te, J. A., Xu, X., Wang, J., Pinon, D. I., Storjohann, L., Bordner, A. J. & Miller, L. J., Sep 27 2011, In : Biochemistry. 50, 38, p. 8181-8192 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Local proliferation and mobilization of CCR3+ CD34+ eosinophil-lineage-committed cells in the lung

Rådinger, M., Bossios, A., Sjöstrand, M., Lu, Y., Malmhäll, C., Dahlborn, A. K., Lee, J. J. & Lötvall, J., Jan 1 2011, In : Immunology. 132, 1, p. 144-154 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice

O'Connell, A. E., Hess, J. A., Santiago, G. A., Nolan, T. J., Lok, J. B., Lee, J. J. & Abraham, D., Jul 1 2011, In : Infection and Immunity. 79, 7, p. 2770-2778 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

MUC1 enhances invasiveness of pancreatic cancer cells by inducing epithelial to mesenchymal transition

Roy, L. D., Sahraei, M., Subramani, D. B., Besmer, D., Nath, S., Tinder, T. L., Bajaj, E., Shanmugam, K., Lee, Y. Y., Hwang, S. I. L., Gendler, S. J. & Mukherjee, P., Mar 24 2011, In : Oncogene. 30, 12, p. 1449-1459 11 p.

Research output: Contribution to journalArticle

156 Scopus citations

Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis

Besmer, D. M., Curry, J. M., Roy, L. D., Tinder, T. L., Sahraei, M., Schettini, J., Hwang, S. I., Lee, Y. Y., Gendler, S. J. & Mukherjee, P., Jul 1 2011, In : Cancer research. 71, 13, p. 4432-4442 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice

Pinkhasov, J., Alvarez, M. L., Rigano, M. M., Piensook, K., Larios, D., Pabst, M., Grass, J., Mukherjee, P., Gendler, S. J., Walmsley, A. M. & Mason, H. S., Dec 1 2011, In : Plant Biotechnology Journal. 9, 9, p. 991-1001 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma

Nair, P., Ochkur, S. I., Protheroe, C., Simms, E., Lee, N. A. & Lee, J. J., Mar 1 2011, In : Allergy, Asthma and Clinical Immunology. 7, 1, 4.

Research output: Contribution to journalArticle

8 Scopus citations

The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation

Riggs, D., Yang, Z., Kloss, J. & Loftus, J. C., Jan 1 2011, In : Cellular Signalling. 23, 1, p. 288-296 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Update on clinical and immunological features of eosinophilic gastrointestinal diseases

Masterson, J. C., Furuta, G. T. & Lee, J. J., Oct 1 2011, In : Current Opinion in Gastroenterology. 27, 6, p. 515-522 8 p.

Research output: Contribution to journalReview article

29 Scopus citations

What is the functional role of the thalidomide binding protein cereblon?

Chang, X. B. & Keith Stewart, A., Dec 1 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 3, p. 287-294 8 p.

Research output: Contribution to journalReview article

43 Scopus citations
2010

Airway eosinophilia in remission and progression of asthma: Accumulation with a fast decline of FEV1

Broekema, M., Volbeda, F., Timens, W., Dijkstra, A., Lee, N. A., Lee, J. J., Lodewijk, M. E., Postma, D. S., Hylkema, M. N. & Ten Hacken, N. H. T., Sep 1 2010, In : Respiratory Medicine. 104, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Altered eosinophil profile in mice with ST6Gal-1 deficiency: An additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation

Nasirikenari, M., Chandrasekaran, E. V., Matta, K. L., Segal, B. H., Bogner, P. N., Lugade, A. A., Thanavala, Y., Lee, J. J. & Lau, J. T. Y., Mar 1 2010, In : Journal of Leukocyte Biology. 87, 3, p. 457-466 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model

Pinkhasov, J., Alvarez, M. L., Pathangey, L. B., Tinder, T. L., Mason, H. S., Walmsley, A. M., Gendler, S. J. & Mukherjee, P., Dec 1 2010, In : Cancer Immunology, Immunotherapy. 59, 12, p. 1801-1811 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation

Pioszak, A. A., Harikumar, K. G., Parker, N. R., Miller, L. J. & Xu, H. E., Apr 16 2010, In : Journal of Biological Chemistry. 285, 16, p. 12435-12444 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints

Dong, M., Pinon, D. I., Bordner, A. J. & Miller, L. J., Oct 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6040-6044 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Eosinophils in health and disease: The LIAR hypothesis

Lee, J. J., Jacobsen, E. A., McGarry, M. P., Schleimer, R. P. & Lee, N. A., Apr 1 2010, In : Clinical and Experimental Allergy. 40, 4, p. 563-575 13 p.

Research output: Contribution to journalComment/debate

156 Scopus citations

Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization

Harikumar, K. G., Ball, A. M., Sexton, P. M. & Miller, L. J., Sep 1 2010, In : Regulatory Peptides. 164, 2-3, p. 113-119 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-a

Conover, C. A., Bale, L. K., Mader, J. R., Mason, M. A., Keenan, K. P. & Marler, R. J., Jun 1 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 6, p. 590-599 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization

Harikumar, K. G., Akgün, E., Portoghese, P. S. & Miller, L. J., Apr 8 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2836-2842 7 p.

Research output: Contribution to journalArticle

14 Scopus citations