Biochemistry and Molecular Biology

Research Output

2010

Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization

Harikumar, K. G., Akgün, E., Portoghese, P. S. & Miller, L. J., Apr 8 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2836-2842 7 p.

Research output: Contribution to journal › Article

14 Scopus citations

Molecular mechanism of ATP-dependent solute transport by multidrug resistance-associated protein 1.

Chang, X. B., 2010, In : Methods in molecular biology (Clifton, N.J.). 596, p. 223-249 27 p.

Research output: Contribution to journal › Review article

24 Scopus citations

MultiRTA: A simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes

Bordner, A. J. & Mittelmann, H. D., Sep 24 2010, In : BMC bioinformatics. 11, 482.

Research output: Contribution to journal › Article

31 Scopus citations

Murine lung eosinophil activation and chemokine production in allergic airway inflammation

Rose, C. E., Lannigan, J. A., Kim, P., Lee, J. J., Fu, S. M. & Sung, S. S. J., Dec 1 2010, In : Cellular and Molecular Immunology. 7, 5, p. 361-374 14 p.

Research output: Contribution to journal › Article

40 Scopus citations

Novel model of TH2-polarized chronic ileitis: The SAMPl mouse

McNamee, E. N., Wermers, J. D., Masterson, J. C., Collins, C. B., Matthew, D. P., Lebsack, B. A., Fillon, S., Robinson, Z. D., Grenawalt, J., Lee, J. J., Jedlicka, P., Furuta, G. T. & Rivera-Nieves, J., Apr 16 2010, In : Inflammatory bowel diseases. 16, 5, p. 743-752 10 p.

Research output: Contribution to journal › Article

26 Scopus citations

Orientation-dependent backbone-only residue pair scoring functions for fixed backbone protein design

Bordner, A. J., Apr 16 2010, In : BMC bioinformatics. 11, 192.

Research output: Contribution to journal › Article

5 Scopus citations

Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model

Bordner, A. J. & Mittelmann, H. D., Jan 20 2010, In : BMC bioinformatics. 11, 41.

Research output: Contribution to journal › Article

23 Scopus citations

Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides

Dong, M., Narang, P., Pinon, D. I., Bordner, A. J. & Miller, L. J., Jun 1 2010, In : Peptides. 31, 6, p. 1094-1098 5 p.

Research output: Contribution to journal › Article

3 Scopus citations

Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo (The Journal of Immunology (2008) 181, (3137-3147))

Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J., Felts, S. J. & Pease, L. R., Jun 1 2010, In : Journal of Immunology. 184, 11, 1 p.

Research output: Contribution to journal › Comment/debate

5 Scopus citations

Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled Receptors

Harikumar, K. G., Dong, M. & Miller, L. J., Jul 15 2010, GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions. John Wiley and Sons, p. 138-164 27 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2

Meurice, N., Wang, L., Lipinski, C. A., Yang, Z., Hulme, C. & Loftus, J. C., Mar 1 2010, In : Journal of Medicinal Chemistry. 53, 2, p. 669-677 9 p.

Research output: Contribution to journal › Article

10 Scopus citations

Targeting Pyk2 for therapeutic intervention

Lipinski, C. A. & Loftus, J. C., Jan 1 2010, In : Expert opinion on therapeutic targets. 14, 1, p. 95-108 14 p.

Research output: Contribution to journal › Review article

70 Scopus citations

Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes

Bordner, A. J., Dec 1 2010, In : PloS one. 5, 12, e14383.

Research output: Contribution to journal › Article

17 Scopus citations

TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling

Paulino, V. M., Yang, Z., Kloss, J., Ennis, M. J., Armstrong, B. A., Loftus, J. C. & Tran, N. L., Nov 1 2010, In : Molecular Cancer Research. 8, 11, p. 1558-1567 10 p.

Research output: Contribution to journal › Article

44 Scopus citations
2009

A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis

Protheroe, C., Woodruff, S. A., de Petris, G., Mukkada, V., Ochkur, S. I., Janarthanan, S., Lewis, J. C., Pasha, S., Lunsford, T., Harris, L., Sharma, V. K., McGarry, M. P., Lee, N. A., Furuta, G. T. & Lee, J. J., Jul 2009, In : Clinical Gastroenterology and Hepatology. 7, 7, p. 749-755.e11

Research output: Contribution to journal › Article

138 Scopus citations

Application of fluorescence resonance energy transfer techniques to establish ligand-receptor orientation.

Harikumar, K. G. & Miller, L. J., 2009, In : Methods in molecular biology (Clifton, N.J.). 552, p. 293-304 12 p.

Research output: Contribution to journal › Article

2 Scopus citations

Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes

Menashi, E. B. & Loftus, J. C., Aug 1 2009, In : Cell and Tissue Research. 337, 2, p. 243-255 13 p.

Research output: Contribution to journal › Article

7 Scopus citations

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

Hou, Y. X., Li, C. Z., Palaniyandi, K., Magtibay, P. M., Homolya, L., Sarkadi, B. & Chang, X. B., Oct 14 2009, In : Biochemistry. 48, 38, p. 9122-9131 10 p.

Research output: Contribution to journal › Article

8 Scopus citations

Eosinophil deficiency compromises parasite survival in chronic nematode infection

Fabre, V., Beiting, D. P., Bliss, S. K., Gebreselassie, N. G., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1577-1583 7 p.

Research output: Contribution to journal › Article

Open Access
107 Scopus citations

Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells

Lotfi, R., Herzog, G. I., DeMarco, R. A., Beer-Stolz, D., Lee, J. J., Rubartelli, A., Schrezenmeier, H. & Lotze, M. T., Oct 15 2009, In : Journal of Immunology. 183, 8, p. 5023-5031 9 p.

Research output: Contribution to journal › Article

66 Scopus citations

Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode strongyloides stercoralis

Stein, L. H., Redding, K. M., Lee, J. J., Nolan, T. J., Schad, G. A., Lok, J. B. & Abraham, D., Oct 1 2009, In : Journal of Innate Immunity. 1, 6, p. 618-630 13 p.

Research output: Contribution to journal › Article

24 Scopus citations

Expression of human MUC1 during early pregnancy in the human MUC1 transgenic mouse model

Dharmaraj, N., Gendler, S. J. & Carson, D. D., Dec 1 2009, In : Biology of Reproduction. 81, 6, p. 1182-1188 7 p.

Research output: Contribution to journal › Article

18 Scopus citations

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor

Gao, F., Harikumar, K. G., Dong, M., Lam, P. C. H., Sexton, P. M., Christopoulos, A., Bordner, A., Abagyan, R. & Miller, L. J., Aug 1 2009, In : Molecular pharmacology. 76, 2, p. 264-274 11 p.

Research output: Contribution to journal › Article

43 Scopus citations

Induced association of μ opioid (MOP) and type 2 cholecystokinin (CCK 2) receptors by novel bivalent ligands

Zheng, Y., Akgiin, E., Harikumar, K. G., Hopson, J., Powers, M. D., Lunzer, M. M., Miller, L. J. & Portoghese, P. S., Jan 22 2009, In : Journal of Medicinal Chemistry. 52, 2, p. 247-258 12 p.

Research output: Contribution to journal › Article

46 Scopus citations

Intravitreal alemtuzumab penetrates full-thickness retina in rabbit eyes

Ekdawi, N. S., Pulido, J. S., Itty, S., Marler, R. J., Herman, D. C., Hardwig, P., Mohney, B. G., Valyi-Nagy, T. & Shukla, D., Nov 1 2009, In : Retina. 29, 10, p. 1532-1534 3 p.

Research output: Contribution to journal › Article

2 Scopus citations

Lack of muc1-regulated β-catenin stability results in aberrant expansion of cd11b +gr1 + Myeloid-derived suppressor cells from the bone marrow

Poh, T. W., Bradley, J. M., Mukherjee, P. & Gendler, S. J., Apr 15 2009, In : Cancer research. 69, 8, p. 3554-3562 9 p.

Research output: Contribution to journal › Article

25 Scopus citations

Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor

Harikumar, K. G., Simms, J., Christopoulos, G., Sexton, P. M. & Miller, L. J., Dec 15 2009, In : Biochemistry. 48, 49, p. 11773-11785 13 p.

Research output: Contribution to journal › Article

38 Scopus citations

Molecular basis of metastasis [8]

Lee, J. J. & Lotze, M. T., Apr 16 2009, In : New England Journal of Medicine. 360, 16, 1 p.

Research output: Contribution to journal › Letter

9 Scopus citations

Mouse eosinophils possess potent antibacterial properties in vivo

Linch, S. N., Kelly, A. M., Danielson, E. T., Pero, R., Lee, J. J. & Gold, J. A., Nov 1 2009, In : Infection and Immunity. 77, 11, p. 4976-4982 7 p.

Research output: Contribution to journal › Article

55 Scopus citations

Pathology in practice

Gades, N. M. & Marier, R. J., Jun 15 2009, In : Journal of the American Veterinary Medical Association. 234, 12, p. 1535-1537 3 p.

Research output: Contribution to journal › Article

3 Scopus citations

Predicting protein-protein binding sites in membrane proteins

Bordner, A. J., Sep 24 2009, In : BMC bioinformatics. 10, 1 p., 1471.

Research output: Contribution to journal › Article

22 Scopus citations

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and Type 2 cholecystokinin receptors

Akgün, E., Körner, M., Gao, F., Harikumar, K. G., Waser, B., Reubi, J. C., Portoghese, P. S. & Miller, L. J., Apr 9 2009, In : Journal of Medicinal Chemistry. 52, 7, p. 2138-2147 10 p.

Research output: Contribution to journal › Article

21 Scopus citations

Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene

Jaskelioff, M., Song, W., Xia, J., Liu, C., Kramer, J., Koido, S., Gendler, S. J., Calderwood, S. K. & Gong, J., Dec 1 2009, In : Oncogene. 28, 48, p. 4225-4236 12 p.

Research output: Contribution to journal › Article

16 Scopus citations

The Pyk2 FERM domain as a target to inhibit glioma migration

Loftus, J. C., Yang, Z., Tran, N. L., Kloss, J., Viso, C., Berens, M. E. & Lipinski, C. A., Jun 1 2009, In : Molecular cancer therapeutics. 8, 6, p. 1505-1514 10 p.

Research output: Contribution to journal › Article

24 Scopus citations

Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function

Fortin, S. P., Ennis, M. J., Savitch, B. A., Carpentieri, D., McDonough, W. S., Winkles, J. A., Loftus, J. C., Kingsley, C., Hostetter, G. & Tran, N. L., Nov 1 2009, In : Molecular Cancer Research. 7, 11, p. 1871-1881 11 p.

Research output: Contribution to journal › Article

43 Scopus citations

Use of fluorescence indicators in receptor ligands.

Harikumar, K. G. & Miller, L. J., 2009, In : Methods in molecular biology (Clifton, N.J.). 552, p. 279-291 13 p.

Research output: Contribution to journal › Article

2 Scopus citations
2008

A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis

Morschl, E., Molina, J. G., Volmer, J. B., Mohsenin, A., Pero, R. S., Hong, J. S., Kheradmand, F., Lee, J. J. & Blackburn, M. R., Dec 1 2008, In : American journal of respiratory cell and molecular biology. 39, 6, p. 697-705 9 p.

Research output: Contribution to journal › Article

39 Scopus citations

Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model

Bakri, S. J., Pulido, J. S., Mukherjee, P., Marler, R. J. & Mukhopadhyay, D., Jan 1 2008, In : Retina. 28, 1, p. 147-149 3 p.

Research output: Contribution to journal › Article

44 Scopus citations

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

Jacobsen, E. A., Ochkur, S. I., Pero, R. S., Taranova, A. G., Protheroe, C. A., Colbert, D. C., Lee, N. A. & Lee, J. J., Mar 17 2008, In : Journal of Experimental Medicine. 205, 3, p. 699-710 12 p.

Research output: Contribution to journal › Article

177 Scopus citations

Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung

Taranova, A. G., Maldonado, D., Vachon, C. M., Jacobsen, E. A., Abdala-Valencia, H., McGarry, M. P., Ochkur, S. I., Protheroe, C. A., Doyle, A., Grant, C. S., Cook-Mills, J., Birnbaumer, L., Lee, N. A. & Lee, J. J., Oct 15 2008, In : Cancer research. 68, 20, p. 8582-8589 8 p.

Research output: Contribution to journal › Article

37 Scopus citations

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

Yousefi, S., Gold, J. A., Andina, N., Lee, J. J., Kelly, A. M., Kozlowski, E., Schmid, I., Straumann, A., Reichenbach, J., Gleich, G. J. & Simon, H. U., Sep 1 2008, In : Nature Medicine. 14, 9, p. 949-953 5 p.

Research output: Contribution to journal › Article

510 Scopus citations

Comprehensive inventory of protein complexes in the Protein Data Bank from consistent classification of interfaces

Bordner, A. J. & Gorin, A. A., May 12 2008, In : BMC bioinformatics. 9, 234.

Research output: Contribution to journal › Article

24 Scopus citations

Corrigendum to "Multidrug resistance protein 1 is not associated to detergent-resistant membranes" [Biochem. Biophys. Res. Commun. 355 (2007) 1025-1030] (DOI:10.1016/j.bbrc.2007.02.075)

Cerf, E., Gasper, R., Belani, J. D., Rychnovsky, S., Chang, X. B., Buyse, F. & Ruysschaert, J. M., Feb 8 2008, In : Biochemical and Biophysical Research Communications. 366, 2, 1 p.

Research output: Contribution to journal › Comment/debate

Dimerization in the absence of higher-order oligomerization of the G protein-coupled secretin receptor

Harikumar, K. G., Happs, R. M. & Miller, L. J., Nov 1 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 11, p. 2555-2563 9 p.

Research output: Contribution to journal › Article

35 Scopus citations

Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor

Lee, J., Thompson, J. R., Botuyan, M. V. & Mer, G., Jan 1 2008, In : Nature Structural and Molecular Biology. 15, 1, p. 109-111 3 p.

Research output: Contribution to journal › Article

143 Scopus citations

Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation

Wu, S. V., Harikumar, K. G., Burgess, R. J., Reeve, J. R. & Miller, L. J., Sep 1 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3, p. G641-G647

Research output: Contribution to journal › Article

10 Scopus citations

Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts

Lipinski, C. A., Tran, N. L., Viso, C., Kloss, J., Yang, Z., Berens, M. E. & Loftus, J. C., Jul 24 2008, In : Journal of neuro-oncology. 90, 2, p. 181-189 9 p.

Research output: Contribution to journal › Article

18 Scopus citations

Extensive exploration of conformational space improves Rosetta results for short protein domains.

Li, Y., Bordner, A. J., Tian, Y., Tao, X. & Gorin, A. A., 2008, In : Computational systems bioinformatics / Life Sciences Society. Computational Systems Bioinformatics Conference. 7, p. 203-209 7 p.

Research output: Contribution to journal › Article

5 Scopus citations

Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity

Tiedemann, R. E., Mao, X., Shi, C. X., Yuan, X. Z., Palmer, S. E., Sebag, M., Marler, R., Chesi, M., Fonseca, R., Bergsagel, P. L., Schimmer, A. D. & Stewart, A. K., May 1 2008, In : Journal of Clinical Investigation. 118, 5, p. 1750-1764 15 p.

Research output: Contribution to journal › Article

45 Scopus citations

Interaction between the bound Mg·ATP and the Walker a serine residue in NBD2 of multidrug resistance-associated protein MRP1 plays a crucial role for the ATP-dependent leukotriene C4 transport

Yang, R., Scavetta, R. & Chang, X. B., Aug 12 2008, In : Biochemistry. 47, 32, p. 8456-8464 9 p.

Research output: Contribution to journal › Article

5 Scopus citations