Biochemistry and Molecular Biology

Research Output

2014

Re-defining the unique roles for eosinophils in allergic respiratory inflammation

Jacobsen, E. A., Lee, N. A. & Lee, J. J., Sep 2014, In : Clinical and Experimental Allergy. 44, 9, p. 1119-1136 18 p.

Research output: Contribution to journalReview article

43 Scopus citations

Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β

Ogawa, H., Ledford, J. G., Mukherjee, S., Aono, Y., Nishioka, Y., Lee, J. J., Izumi, K. & Hollingsworth, J. W., Nov 29 2014, In : Respiratory Research. 15, 1, 143.

Research output: Contribution to journalArticle

7 Scopus citations

Sustained inflammation and differential expression of interferons type I and III in PVM-infected interferon-gamma (IFNγ) gene-deleted mice

Glineur, S. F., Bowen, A. B., Percopo, C. M., Garcia-Crespo, K. E., Dyer, K. D., Ochkur, S. I., Lee, N. A., Lee, J. J., Domachowske, J. B. & Rosenberg, H. F., Nov 2014, In : Virology. 468-470, p. 140-149 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma

Kusne, Y., Carrera-Silva, E. A., Perry, A. S., Rushing, E. J., Mandell, E. K., Dietrich, J. D., Errasti, A. E., Gibbs, D., Berens, M. E., Loftus, J. C., Hulme, C., Yang, W., Lu, Z., Aldape, K., Sanai, N., Rothlin, C. V. & Ghosh, S., Aug 12 2014, In : Science Signaling. 7, 338, ra75.

Research output: Contribution to journalArticle

31 Scopus citations

T-helper 2 cytokines, transforming growth factor β1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis

Rieder, F., Nonevski, I., Ma, J., Ouyang, Z., West, G., Protheroe, C., Depetris, G., Schirbel, A., Lapinski, J., Goldblum, J., Bonfield, T., Lopez, R., Harnett, K., Lee, J., Hirano, I., Falk, G., Biancani, P. & Fiocchi, C., May 2014, In : Gastroenterology. 146, 5, p. 1266-1277.e9

Research output: Contribution to journalArticle

67 Scopus citations

Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex

Lee, L. T. O., Ng, S. Y. L., Chu, J. Y. S., Sekar, R., Harikumar, K. G., Miller, L. J. & Chow, B. K. C., Jun 2014, In : FASEB Journal. 28, 6, p. 2632-2644 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

Adenomatous polyps are drivenbymicrobe-instigated focal inflammation and are controlled by IL-10-producing T cells

Dennis, K. L., Wang, Y., Blatner, N. R., Wang, S., Saadalla, A., Trudeau, E., Roers, A., Weaver, C. T., Lee, J. J., Gilbert, J. A., Chang, E. B. & Khazaie, K., Oct 1 2013, In : Cancer research. 73, 19, p. 5905-5913 9 p.

Research output: Contribution to journalArticle

153 Scopus citations

An essential role for Rab27a GTPase in eosinophil exocytosis

Kim, J. D., Willetts, L., Ochkur, S., Srivastava, N., Hamburg, R., Shayeganpour, A., Seabra, M. C., Lee, J. J., Moqbel, R. & Lacy, P., Dec 1 2013, In : Journal of Leukocyte Biology. 94, 6, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Animal Models of Human Pathology

Lee, J. J., Blanchard, C., Masterson, J. C., Furuta, G. T., Waddell, A., Hogan, S. P., Yamada, Y., Cancelas, J. A., Rothenberg, M. E. & (Wole) Odemuyiwa, S. O., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 537-575 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Comparison of three staining methods to identify eosinophils in formalin-fixed canine skin

Gomes, P., Torres, S. M. F., Plager, D. A., Jessen, C. R. & Lee, J. J., Jun 1 2013, In : Veterinary Dermatology. 24, 3, p. 323-e72

Research output: Contribution to journalArticle

14 Scopus citations

Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation

Ochkur, S. I., Protheroe, C. A., Li, W., Colbert, D. C., Zellner, K. R., Shen, H. H., Luster, A. D., Irvin, C. G., Lee, J. J. & Lee, N. A., Dec 1 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Downregulation of hematopoietic MUC1 during Experimental colitis increases tumor-promoting myeloid-derived suppressor cells

Poh, T. W., Madsen, C. S., Gorman, J. E., Marler, R. J., Leighton, J. A., Cohen, P. A. & Gendler, S. J., Sep 15 2013, In : Clinical Cancer Research. 19, 18, p. 5039-5052 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effect of proton pump inhibitor on esophageal eosinophilia

Schroeder, S., Capocelli, K. E., Masterson, J. C., Harris, R., Protheroe, C., Lee, J. J. & Furuta, G. T., Feb 1 2013, In : Journal of pediatric gastroenterology and nutrition. 56, 2, p. 166-172 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Emerging Concepts

Lee, J. J., Ptaschinski, C., Plank, M., Mattes, J., Foster, P. S., Balla, K. M., Traver, D., Ilarraza, R., Orihara, K., Arizmendi, N., Moqbel, R., Odemuyiwa, S. O., Smith, D. E. & Comeau, M. R., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 607-641 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophil Cell-Cell Communication

Prussin, C., Scott, G. D., Fryer, A. D., Schroeder, S., Masterson, J. C., Fillon, S., Furuta, G. T., Akuthota, P., Xenakis, J. J., Wang, H., Weller, P. F., Jacobsen, E. A., Teplinsky, A., Elishmereni, M., Katz, H. R., Levi-Schaffer, F., Chu, V. T., Berek, C., Sexton, D. W., Walsh, G. M. & 5 others, (Wole) Odemuyiwa, S. O., Tulic, M. K., Cravetchi, V. O., Lee, J. J. & Moqbel, R., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 329-390 62 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophilopoiesis

Maltby, S., McNagny, K. M., Ackerman, S. J., Du, J., Mori, Y., Iwasaki, H., Akashi, K., Takatsu, K., Rådinger, M., Bossios, A., Lötvall, J. & Lee, N. A., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 73-119 47 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia

Nair, P., Ochkur, S. I., Protheroe, C., Radford, K., Efthimiadis, A., Lee, N. A. & Lee, J. J., Sep 1 2013, In : Allergy: European Journal of Allergy and Clinical Immunology. 68, 9, p. 1177-1184 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Eosinophils in Health and Disease

Lee, J. & Rosenberg, H., 2013, Elsevier Inc.

Research output: Book/ReportBook

20 Scopus citations

Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Shim, K. G., Nguyen, D. T. C., Protheroe, C., Colbert, D., Kloeber, J., Neely, J., Shim, K. P., Dyer, K. D., Rosenberg, H. F., Lee, J. J. & Lee, N. A., Aug 1 2013, In : Blood. 122, 5, p. 781-790 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., Willetts, L., Shim, K., Neely, J., Kloeber, J., LeSuer, W. E., Pero, R. S., Lacy, P., Moqbel, R., Lee, N. A. & Lee, J. J., Jul 1 2013, In : Journal of Leukocyte Biology. 94, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation

Mills, L. D., Zhang, Y., Marler, R. J., Herreros-Villanueva, M., Zhang, L., Almada, L. L., Couch, F., Wetmore, C., Di Magliano, M. P. & Fernandez-Zapico, M. E., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11786-11794 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Mast cells are required for full expression of allergen/SEB-Induced skin inflammation

Ando, T., Matsumoto, K., Namiranian, S., Yamashita, H., Glatthorn, H., Kimura, M., Dolan, B. R., Lee, J. J., Galli, S. J., Kawakami, Y., Jamora, C. & Kawakami, T., Dec 2013, In : Journal of Investigative Dermatology. 133, 12, p. 2695-2705 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Membrane cholesterol affects stimulus-activity coupling in type 1, but not type 2, CCK receptors: Use of cell lines with elevated cholesterol

Harikumar, K. G., Potter, R. M., Patil, A., Echeveste, V. & Miller, L. J., Mar 1 2013, In : Lipids. 48, 3, p. 231-244 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy

Mader, J. R., Resch, Z. T., McLean, G. R., Mikkelsen, J. H., Oxvig, C., Marler, R. J. & Conover, C. A., Sep 20 2013, In : Journal of Endocrinology. 219, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Modification of the tumor microenvironment as a novel target of renal cell carcinoma therapeutics

Finke, J. H., Rayman, P. A., Ko, J. S., Bradley, J. M., Gendler, S. J. & Cohen, P. A., Jul 1 2013, In : Cancer Journal (United States). 19, 4, p. 353-364 12 p.

Research output: Contribution to journalReview article

31 Scopus citations

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor

Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B. R., Abagyan, R., Christopoulos, A., Sexton, P. M. & Miller, L. J., Jul 19 2013, In : Journal of Biological Chemistry. 288, 29, p. 21082-21095 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Reciprocal Activation of Transcription Factors Underlies the Dichotomy between Proliferation and Invasion of Glioma Cells

Dhruv, H. D., McDonough Winslow, W. S., Armstrong, B., Tuncali, S., Eschbacher, J., Kislin, K., Loftus, J. C., Tran, N. L. & Berens, M. E., Aug 15 2013, In : PloS one. 8, 8, e72134.

Research output: Contribution to journalArticle

30 Scopus citations

Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis

Dhruv, H., Loftus, J. C., Narang, P., Petit, J. L., Fameree, M., Burton, J., Tchegho, G., Chow, D., Yin, H., Al-Abed, Y., Berens, M. E., Tran, N. L. & Meurice, N., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32261-32276 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

Ke, J., Harikumar, K. G., Erice, C., Chen, C., Gu, X., Wang, L., Parker, N., Cheng, Z., Xu, W., Williams, B. O., Melcher, K., Miller, L. J. & Eric Xu, H., Nov 1 2013, In : Genes and Development. 27, 21, p. 2305-2319 15 p.

Research output: Contribution to journalArticle

47 Scopus citations

Structure-based prediction of major histocompatibility complex (MHC) epitopes

Bordner, A. J., Sep 20 2013, Immunoproteomics: Methods and Protocols. Fulton, K. & Twine, S. (eds.). p. 323-343 21 p. (Methods in Molecular Biology; vol. 1061).

Research output: Chapter in Book/Report/Conference proceedingChapter

Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model

Ghosh, S. K., Uchida, M., Yoo, B., Ross, A. W., Gendler, S. J., Gong, J., Moore, A. & Medarova, Z., Apr 15 2013, In : International Journal of Cancer. 132, 8, p. 1860-1867 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

The consequences of not having eosinophils

Gleich, G. J., Klion, A. D., Lee, J. J. & Weller, P. F., Jul 1 2013, In : Allergy: European Journal of Allergy and Clinical Immunology. 68, 7, p. 829-835 7 p.

Research output: Contribution to journalReview article

66 Scopus citations

The oesophageal string test: A novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis

Furuta, G. T., Kagalwalla, A. F., Lee, J. J., Alumkal, P., Maybruck, B. T., Fillon, S., Masterson, J. C., Ochkur, S., Protheroe, C., Moore, W., Pan, Z., Amsden, K., Robinson, Z., Capocelli, K., Mukkada, V., Atkins, D., Fleischer, D., Hosford, L., Kwatia, M. A., Schroeder, S. & 4 others, Kelly, C., Lovell, M., Melin-Aldana, H. & Ackerman, S. J., Oct 1 2013, In : Gut. 62, 10, p. 1395-1405 11 p.

Research output: Contribution to journalArticle

137 Scopus citations
21 Scopus citations

TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance

Loftus, J. C., Dhruv, H., Tuncali, S., Kloss, J., Yang, Z., Schumacher, C. A., Cao, B., Williams, B. O., Eschbacher, J. M., Ross, J. T. D. & Tran, N. L., Aug 1 2013, In : Molecular Cancer Research. 11, 8, p. 865-874 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2012

A sensitive high throughput ELISA for human eosinophil peroxidase: A specific assay to quantify eosinophil degranulation from patient-derived sources

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Condjella, R. M., Bersoux, S., Helmers, R. A., Moqbel, R., Lacy, P., Kelly, E. A., Jarjour, N. N., Kern, R., Peters, A., Schleimer, R. P., Furuta, G. T., Nair, P., Lee, J. J. & Lee, N. A., Oct 31 2012, In : Journal of Immunological Methods. 384, 1-2, p. 10-20 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
14 Scopus citations

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Fortin, S. P., Ennis, M. J., Schumacher, C. A., Zylstra-Diegel, C. R., Williams, B. O., Ross, J. T. D., Winkles, J. A., Loftus, J. C., Symons, M. H. & Tran, N. L., Jul 1 2012, In : Molecular Cancer Research. 10, 7, p. 958-968 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Detection of Progressive Myocardial Tissue Injury by Ultrasonic Integrated Backscatter Immediately After Coronary Reperfusion

Katayama, M., Jiamsripong, P., McMahon, E. M., Lombari, T. R., Bukatina, A. E., Wu, Q., Marler, R. J. & Belohlavek, M., Sep 1 2012, In : Ultrasound in Medicine and Biology. 38, 9, p. 1662-1669 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

Potter, R. M., Harikumar, K. G., Wu, S. V. & Miller, L. J., Jan 1 2012, In : Journal of Lipid Research. 53, 1, p. 137-148 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion

Whitsett, T. G., Cheng, E., Inge, L., Asrani, K., Jameson, N. M., Hostetter, G., Weiss, G. J., Kingsley, C. B., Loftus, J. C., Bremner, R., Tran, N. L. & Winkles, J. A., Jul 1 2012, In : American Journal of Pathology. 181, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

Kagalwalla, A. F., Akhtar, N., Woodruff, S. A., Rea, B. A., Masterson, J. C., Mukkada, V., Parashette, K. R., Du, J., Fillon, S., Protheroe, C. A., Lee, J. J., Amsden, K., Melin-Aldana, H., Capocelli, K. E., Furuta, G. T. & Ackerman, S. J., May 2012, In : Journal of Allergy and Clinical Immunology. 129, 5, p. 1387-1396.e6

Research output: Contribution to journalArticle

123 Scopus citations

Eosinophils preserve parasitic nematode larvae by regulating local immunity

Gebreselassie, N. G., Moorhead, A. R., Fabre, V., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2012, In : Journal of Immunology. 188, 1, p. 417-425 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance

Hiddinga, H. J., Sakagashira, S., Ishigame, M., Madde, P., Sanke, T., Nanjo, K., Kudva, Y. C., Lee, J. J., van Deursen, J. & Eberhardt, N. L., Apr 1 2012, In : Journal of Diabetes Investigation. 3, 2, p. 138-147 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Force fields for homology modeling

Bordner, A. J., Mar 16 2012, Homology Modeling: Methods and Protocols. Orry, A. & Abagyan, R. (eds.). p. 83-106 24 p. (Methods in Molecular Biology; vol. 857).

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, K. G., Wootten, D., Pinon, D. I., Koole, C., Ball, A. M., Furness, S. G. B., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. & Sexton, P. M., Nov 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 45, p. 18607-18612 6 p.

Research output: Contribution to journalArticle

41 Scopus citations
13 Scopus citations

Human versus mouse eosinophils: "That which we call an eosinophil, by any other name would stain as red"

Lee, J. J., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Condjella, R. M., Doyle, A. D., Luo, H., Zellner, K. R., Protheroe, C. A., Willetts, L., Lesuer, W. E., Colbert, D. C., Helmers, R. A., Lacy, P., Moqbel, R. & Lee, N. A., Sep 2012, In : Journal of Allergy and Clinical Immunology. 130, 3, p. 572-584 13 p.

Research output: Contribution to journalReview article

96 Scopus citations

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

Lakshminarayanan, V., Thompson, P., Wolfert, M. A., Buskas, T., Bradley, J. M., Pathangey, L. B., Madsen, C. S., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 261-266 6 p.

Research output: Contribution to journalArticle

199 Scopus citations

Interleukin 5 is protective during sepsis in an eosinophil-independent manner

Linch, S. N., Danielson, E. T., Kelly, A. M., Tamakawa, R. A., Lee, J. J. & Gold, J. A., Aug 1 2012, In : American journal of respiratory and critical care medicine. 186, 3, p. 246-254 9 p.

Research output: Contribution to journalArticle

38 Scopus citations