Biochemistry and Molecular Biology

Research Output

2004

Allergen-induced traffic of bone marrow eosinophils, neutrophils and lymphocytes to airways

Johansson, A. K., Sergejeva, S., Sjöstrand, M., Lee, J. J. & Lötvall, J., Nov 1 2004, In : European Journal of Immunology. 34, 11, p. 3135-3145 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer

Basu, G. D., Pathangey, L. B., Tinder, T. L., LaGioia, M., Gendler, S. J. & Mukherjee, P., Nov 1 2004, In : Molecular Cancer Research. 2, 11, p. 632-642 11 p.

Research output: Contribution to journalArticle

129 Scopus citations

Defining a link with asthma in mice congenitally deficient in eosinophils

Lee, J. J., Dimina, D., Macias, M. M. P., Ochkur, S. I., McGarry, M. P., O'Neill, K. R., Protheroe, C., Pero, R., Nguyen, T., Cormier, S. A., Lenkiewicz, E., Colbert, D., Rinaldi, L., Ackerman, S. J., Irvin, C. G. & Lee, N. A., Sep 17 2004, In : Science. 305, 5691, p. 1773-1776 4 p.

Research output: Contribution to journalArticle

552 Scopus citations

Designer Glycopeptides for Cytotoxic T Cell-based Elimination of Carcinomas

Xu, Y., Gendler, S. J. & Franco, A., Mar 1 2004, In : Journal of Experimental Medicine. 199, 5, p. 707-716 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Downregulation of Muc1 in MMTV-c-Neu tumors

Adriance, M. C. & Gendler, S. J., Jan 22 2004, In : Oncogene. 23, 3, p. 697-705 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of raloxifene hydrochloride on endometrial cancer cells in vitro

Hibner, M., Magrina, J. F., Lefler, S. R., Cornella, J. L., Pizarro, A. R. & Loftus, J. C., Jun 1 2004, In : Gynecologic oncology. 93, 3, p. 642-646 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endocytic trafficking routes of wild type and ΔF508 cystic fibrosis transmembrane conductance regulator

Gentzsch, M., Chang, X. B., Cui, L., Wu, Y., Ozols, V. V., Choudhury, A., Pagano, R. E. & Riordan, J. R., Jun 1 2004, In : Molecular biology of the cell. 15, 6, p. 2684-2696 13 p.

Research output: Contribution to journalArticle

169 Scopus citations

Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen

Clark, K., Simson, L., Newcombe, N., Koskinen, A. M. L., Mattes, J., Lee, N. A., Lee, J. J., Dent, L. A., Matthaei, K. I. & Foster, P. S., Jun 1 2004, In : Journal of Leukocyte Biology. 75, 6, p. 1001-1009 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Fluorescent modified phosphatidylcholine floppase activity of reconstituted multidrug resistance-associated protein MRP1

Huang, Z., Chang, X., Riordan, J. R. & Huang, Y., Jan 28 2004, In : Biochimica et Biophysica Acta - Biomembranes. 1660, 1-2, p. 155-163 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: Role for tethered mucins as barriers to lumenal infection

Stonebraker, J. R., Wagner, D., Lefensty, R. W., Burns, K., Gendler, S. J., Bergelson, J. M., Boucher, R. C., O'Neal, W. K. & Pickles, R. J., Dec 1 2004, In : Journal of virology. 78, 24, p. 13755-13768 14 p.

Research output: Contribution to journalArticle

59 Scopus citations

G-protein-dependent cell surface dynamics of the human serotonin 1A receptor tagged to yellow fluorescent protein

Pucadyil, T. J., Kalipatnapu, S., Harikumar, K. G., Rangaraj, N., Karnik, S. S. & Chattopadhyay, A., Dec 21 2004, In : Biochemistry. 43, 50, p. 15852-15862 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Immunoglobulin E and Eosinophil-Dependent Protective Immunity to Larval Onchocerca volvulus in Mice Immunized with Irradiated Larvae

Abraham, D., Leon, O., Schnyder-Candrian, S., Wang, C. C., Galioto, A. M., Kerepesi, L. A., Lee, J. J. & Lustigman, S., Feb 1 2004, In : Infection and Immunity. 72, 2, p. 810-817 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Immunopathogenesis of Experimental Ulcerative Colitis is Mediated by Eosinophil Peroxidase

Forbes, E., Murase, T., Yang, M., Matthaei, K. I., Lee, J. J., Lee, N. A., Foster, P. S. & Hogan, S. P., May 1 2004, In : Journal of Immunology. 172, 9, p. 5664-5675 12 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/- mice

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Sep 1 2004, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 287, 3 50-3, p. G547-G554

Research output: Contribution to journalArticle

20 Scopus citations

Large-scale prediction of protein geometry and stability changes for arbitrary single point mutations

Bordner, A. J. & Abagyan, R. A., Nov 1 2004, In : Proteins: Structure, Function and Genetics. 57, 2, p. 400-413 14 p.

Research output: Contribution to journalArticle

87 Scopus citations

Ligand binding characteristics of the human serotonin 1A receptor heterologously expressed in CHO cells

Kalipatnapu, S., Pucadyil, T. J., Harikumar, K. G. & Chattopadhyay, A., Apr 1 2004, In : Bioscience reports. 24, 2, p. 101-115 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

Measurement of Intermolecular Distances for the Natural Agonist Peptide Docked at the Cholecystokinin Receptor Expressed in Situ Using Fluorescence Resonance Energy Transfer

Harikumar, K. G., Pinon, D. I., Wessels, W. S., Dawson, E. S., Lybrand, T. P., Prendergast, F. G. & Miller, L. J., Jan 1 2004, In : Molecular pharmacology. 65, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

MUC1 can interact with adenomatous polyposis coli in breast cancer

Hattrup, C. L., Fernandez-Rodriguez, J., Schroeder, J. A., Hansson, G. C. & Gendler, S. J., Apr 2 2004, In : Biochemical and Biophysical Research Communications. 316, 2, p. 364-369 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation

Schroeder, J. A., Al Masri, A., Adriance, M. C., Tessier, J. C., Kotlarczyk, K. L., Thompson, M. C. & Gendler, S. J., Jul 29 2004, In : Oncogene. 23, 34, p. 5739-5747 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: The possible role of TGFβ2

Choudhury, A., Moniaux, N., Ulrich, A. B., Schmied, B. M., Standop, J., Pour, P. M., Gendler, S. J., Hollingsworth, M. A., Aubert, J. P. & Batra, S. K., Feb 9 2004, In : British journal of cancer. 90, 3, p. 657-664 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1

Zhao, Q. & Chang, X. B., Nov 19 2004, In : Journal of Biological Chemistry. 279, 47, p. 48505-48512 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Peroxisome proliferator-activated receptor γ controls Muc1 transcription in trophoblasts

Shalom-Barak, T., Nicholas, J. M., Wang, Y., Zhang, X., Ong, E. S., Young, T. H., Gendler, S. J., Evans, R. M. & Barak, Y., Dec 1 2004, In : Molecular and cellular biology. 24, 24, p. 10661-10669 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient skeletal muscle

Wehling-Henricks, M., Lee, J. J. & Tidball, J. G., Sep 1 2004, In : Neuromuscular Disorders. 14, 8-9, p. 483-490 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer

Pockaj, B. A., Basu, G. D., Pathangey, L. B., Gray, R. J., Hernandez, J. L., Gendler, S. J. & Mukherjee, P., Dec 1 2004, In : Annals of surgical oncology. 11, 3, p. 328-339 12 p.

Research output: Contribution to journalArticle

140 Scopus citations

Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator

Chappe, V., Hinkson, D. A., Howell, L. D., Evagelidis, A., Liao, J., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Jan 1 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 1, p. 390-395 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Mar 1 2004, In : Journal of Lipid Research. 45, 3, p. 438-447 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model

Mukherjee, P., Tinder, T. L., Pathangey, L. B., Chen, L. & Gendler, S. J., Jan 1 2004, In : Breast Disease. 20, p. 53-63 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Verapamil and its derivative trigger apoptosis through glutathione extrusion by multidrug resistance protein MRP1

Trompier, D., Chang, X. B., Barattin, R., Du Moulinet D'Hardemare, A., Di Pietro, A. & Baubichon-Cortay, H., Jul 15 2004, In : Cancer research. 64, 14, p. 4950-4956 7 p.

Research output: Contribution to journalArticle

97 Scopus citations
2003

Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology

Justice, J. P., Borchers, M. T., Crosby, J. R., Hines, E. M., Shen, H. H., Ochkur, S. I., McGarry, M. P., Lee, N. A. & Lee, J. J., Jan 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 1 28-1, p. L169-L178

Research output: Contribution to journalArticle

89 Scopus citations

A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse

Shen, H. H. H., Ochkur, S. I., McGarry, M. P., Crosby, J. R., Hines, E. M., Borchers, M. T., Wang, H., Biechelle, T. L., O'Neill, K. R., Ansay, T. L., Colbert, D. C., Cormier, S. A., Justice, J. P., Lee, N. A. & Lee, J. J., Mar 15 2003, In : Journal of Immunology. 170, 6, p. 3296-3305 10 p.

Research output: Contribution to journalArticle

Open Access
139 Scopus citations

A mutation in the integrin αIIb subunit that selectively inhibits αIIbβ3 receptor function

Perkins, K. B. & Loftus, J. C., Nov 2003, In : Thrombosis and Haemostasis. 90, 5, p. 853-862 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP·Vi trapping at the second domain

Hou, Y. X., Riordan, J. R. & Chang, X. B., Feb 7 2003, In : Journal of Biological Chemistry. 278, 6, p. 3599-3605 7 p.

Research output: Contribution to journalArticle

31 Scopus citations
42 Scopus citations
59 Scopus citations

Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models

Hao, M., Comier, S., Wang, M., Lee, J. J. & Nel, A., Nov 2003, In : Journal of Allergy and Clinical Immunology. 112, 5, p. 905-914 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation

Lipinski, C. A., Tran, N. L., Bay, C., Kloss, J., McDonough, W. S., Beaudry, C., Berens, M. E. & Loftus, J. C., Mar 1 2003, In : Molecular Cancer Research. 1, 5, p. 323-332 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Direct derivation of van der Waals force field parameters from quantum mechanical interaction energies

Bordner, A. J., Cavasotto, C. N. & Abagyan, R. A., Sep 4 2003, In : Journal of Physical Chemistry B. 107, 35, p. 9601-9609 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Heterodimerization of Type A and B Cholecystokinin Receptors Enhance Signaling and Promote Cell Growth

Cheng, Z. J., Harikumar, K. G., Holicky, E. L. & Miller, L. J., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52972-52979 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Immunotherapy of spontaneous mammary carcinoma with fusions of dendritic cells and mucin 1-positive carcinoma cells

Chen, D., Xia, J., Tanaka, Y., Chen, H., Koido, S., Wernet, O., Mukherjee, P., Gendler, S. J., Kufe, D. & Gong, J., Jun 1 2003, In : Immunology. 109, 2, p. 300-307 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione

Manciu, L., Chang, X. B., Buyse, F., Hou, Y. X., Gustot, A., Riordani, J. R. & Ruysschaert, J. M., Jan 31 2003, In : Journal of Biological Chemistry. 278, 5, p. 3347-3356 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Kinetics of cellular responses to intraperitoneal Brugia pahangi infections in normal and immunodeficient mice

Ramalingam, T., Rajan, B., Lee, J. & Rajan, T. V., Aug 1 2003, In : Infection and Immunity. 71, 8, p. 4361-4367 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Methacholine-induced airway hyperresponsiveness is dependent on Gαq signaling

Borchers, M. T., Biechele, T., Justice, J. P., Ansay, T., Cormier, S., Mancino, V., Wilkie, T. M., Simon, M. I., Lee, N. A. & Lee, J. J., Jul 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 1 29-1, p. L114-L120

Research output: Contribution to journalArticle

18 Scopus citations

Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: Identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G)

Aizawa, H., Zimmermann, N., Carrigan, P. E., Lee, J. J., Rothenberg, M. E. & Bochner, B. S., Nov 1 2003, In : Genomics. 82, 5, p. 521-530 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

MUC1 alters β-catenin-dependent tumor formation and promotes cellular invasion

Schroeder, J. A., Adriance, M. C., Thompson, M. C., Camenisch, T. D. & Gendler, S. J., Mar 6 2003, In : Oncogene. 22, 9, p. 1324-1332 9 p.

Research output: Contribution to journalArticle

135 Scopus citations

Mucin 1-specific immunotherapy in a mouse model of spontaneous breast cancer

Mukherjee, P., Madsen, C. S., Ginardi, A. R., Tinder, T. L., Jacobs, F., Parker, J., Agrawal, B., Longenecker, B. M. & Gendler, S. J., Jan 1 2003, In : Journal of Immunotherapy. 26, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

74 Scopus citations

Multiple flavonoid-binding sites within multidrug resistance protein MRP1

Trompier, D., Baubichon-Cortay, H., Chang, X. B., Maitrejean, M., Barron, D., Riordan, J. R. & Di Pietro, A., Oct 1 2003, In : Cellular and Molecular Life Sciences. 60, 10, p. 2164-2177 14 p.

Research output: Contribution to journalArticle

63 Scopus citations

Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice

Hinojosa-Kurtzberg, A. M., Johansson, M. E. V., Madsen, C. S., Hansson, G. C. & Gendler, S. J., May 1 2003, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 284, 5 47-5, p. G853-G862

Research output: Contribution to journalArticle

23 Scopus citations

Patterns of MUC1 tissue expression defined by an Anti-MUC1 cytoplasmic tail monoclonal antibody in breast cancer

Croce, M. V., Isla-Larrain, M. T., Rua, C. E., Rabassa, M. E., Gendler, S. J. & Segal-Eiras, A., Jun 1 2003, In : Journal of Histochemistry and Cytochemistry. 51, 6, p. 781-788 8 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA

Chappe, V., Hinkson, D. A., Zhu, T., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Apr 1 2003, In : Journal of Physiology. 548, 1, p. 39-52 14 p.

Research output: Contribution to journalReview article

62 Scopus citations

Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells

Xia, J., Tanaka, Y., Koido, S., Liu, C., Mukherjee, P., Gendler, S. J. & Gong, J., Feb 15 2003, In : Journal of Immunology. 170, 4, p. 1980-1986 7 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations