Biochemistry and Molecular Biology

Research Output

2016

Signaling modification by GPCR heteromer and its implication on X-linked nephrogenic diabetes insipidus

Ng, H. K. H., Harikumar, K. G., Miller, L. J. & Chow, B. K. C., Sep 1 2016, In : PLoS One. 11, 9, e0163086.

Research output: Contribution to journalArticle

Structure and function of Cross-class complexes of G Protein-Coupled secretin and angiotensin 1a receptors

Harikumar, K. G., Augustine, M. L., Lee, L. T. O., Chow, B. K. C. & Miller, L. J., Aug 12 2016, In : Journal of Biological Chemistry. 291, 33, p. 17332-17344 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis

Mcnamee, E. N., Biette, K. A., Hammer, J., Harris, R., Miyazawa, H., Lee, J. J., Furuta, G. T. & Masterson, J. C., 2016, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

3 Scopus citations

The potential for repositioning antithyroid agents as antiasthma drugs

Suzuki, S., Ogawa, M., Ohta, S., Arima, K., Nunomura, S., Nanri, Y., Mitamura, Y., Yoshihara, T., Nakamura, Y., Yamauchi, K., Chibana, K., Ishii, Y., Lee, J. J., Aratani, Y., Kakuta, S., Kubo, S., Iwakura, Y., Yoshida, H. & Izuhara, K., 2016, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

3 Scopus citations

Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa Women’s Health Study

Prizment, A. E., Vierkant, R. A., Smyrk, T. C., Tillmans, L. S., Lee, J. J., Sriramarao, P., Nelson, H. H., Lynch, C. F., Thibodeau, S. N., Church, T. R., Cerhan, J. R., Anderson, K. E. & Limburg, P. J., Feb 26 2016, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Development of an endometrial ablation model in New Zealand White rabbits

AlHilli, M. M., Brost, B. C., Marler, R. J., Mariani, A., Hopkins, M. R. & Famuyide, A. O., Aug 1 2015, In : The Journal of reproductive medicine. 60, 4, p. 315-323 9 p.

Research output: Contribution to journalArticle

Differential activation of airway eosinophils induces IL-13-mediated allergic Th2 pulmonary responses in mice

Jacobsen, E., Doyle, A. D., Colbert, D. C., Zellner, K. R., Protheroe, C. A., Lesuer, W. E., Lee, N. A. & Lee, J. J., Sep 1 2015, In : Allergy: European Journal of Allergy and Clinical Immunology. 70, 9, p. 1148-1159 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease

Su, Y. C., Townsend, D., Herrero, L. J., Zaid, A., Rolph, M. S., Gahan, M. E., Nelson, M. A., Rudd, P. A., Matthaei, K. I., Foster, P. S., Dent, L., Tripp, R. A., Lee, J., Simson, L. & Mahalingam, S., Jan 1 2015, In : Journal of virology. 89, 3, p. 1564-1578 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant

Yamada, K. J., Barker, T., Dyer, K. D., Rice, T. A., Percopo, C. M., Garcia-Crespo, K. E., Cho, S., Lee, J. J., Druey, K. M. & Rosenberg, H. F., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 8863-8875 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice

Lee, J. J., Protheroe, C. A., Luo, H., Ochkur, S. I., Scott, G. D., Zellner, K. R., Raish, R. J., Dahl, M. V., Vega, M. L., Conley, O., Condjella, R. M., Kloeber, J. A., Neely, J. L., Patel, Y. S., Maizer, P., Mazzolini, A., Fryer, A. D., Jacoby, N. W., Jacoby, D. B. & Lee, N. A., Feb 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 477-487.e1

Research output: Contribution to journalArticle

15 Scopus citations

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis

Masterson, J. C., McNamee, E. N., Fillon, S. A., Hosford, L., Harris, R., Fernando, S. D., Jedlicka, P., Iwamoto, R., Jacobsen, E., Protheroe, C., Eltzschig, H. K., Colgan, S. P., Arita, M., Lee, J. J. & Furuta, G. T., Aug 1 2015, In : Gut. 64, 8, p. 1236-1247 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis

Masterson, J. C., Capocelli, K. E., Hosford, L., Biette, K., McNamee, E. N., De Zoeten, E. F., Harris, R., Fernando, S. D., Jedlicka, P., Protheroe, C., Lee, J. J. & Furuta, G. T., Jul 20 2015, In : Inflammatory Bowel Diseases. 21, 10, p. 2429-2440 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury

Huang, L., Beiting, D. P., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Lee, N. A., Lee, J. J. & Appleton, J. A., 2015, In : PLoS Pathogens. 11, 12, e1005347.

Research output: Contribution to journalArticle

22 Scopus citations

Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge

Takeda, K., Shiraishi, Y., Ashino, S., Han, J., Jia, Y., Wang, M., Lee, N. A., Lee, J. J. & Gelfand, E. W., Feb 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 451-460.e5

Research output: Contribution to journalArticle

15 Scopus citations

Eosinophils mediate protective immunity against secondary nematode infection

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Luber, K. L., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2015, In : Journal of Immunology. 194, 1, p. 283-290 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Erratum: Mast cells are required for full expression of allergen/SEB-induced skin inflammation (Journal of Investigative Dermatology (2013) 133 (2695-2705) DOI: 10.1038/jid.2013.250)

Ando, T., Matsumoto, K., Namiranian, S., Yamashita, H., Glatthorn, H., Kimura, M., Dolan, B. R., Lee, J. J., Galli, S. J., Kawakami, Y., Jamora, C. & Kawakami, T., Mar 12 2015, In : Journal of Investigative Dermatology. 135, 3, 1 p.

Research output: Contribution to journalComment/debate

Exogenous interleukin-17a inhibits eosinophil differentiation and alleviates allergic airway inflammation

Tian, B. P., Hua, W., Xia, L. X., Jin, Y., Lan, F., Lee, J. J., Lee, N. A., Li, W., Ying, S. M., Chen, Z. H. & Shen, H. H., Apr 1 2015, In : American Journal of Respiratory Cell and Molecular Biology. 52, 4, p. 459-470 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
7 Scopus citations

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Thompson, P., Lakshminarayanan, V., Supekar, N. T., Bradley, J. M., Cohen, P. A., Wolfert, M. A., Gendler, S. J. & Boons, G. J., May 28 2015, In : Chemical Communications. 51, 50, p. 10214-10217 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Low-Dose Gamma Irradiation of Decellularized Heart Valves Results in Tissue Injury In Vitro and In Vivo

Helder, M. R. K., Hennessy, R. S., Spoon, D. B., Tefft, B. J., Witt, T. A., Marler, R. J., Pislaru, S. V., Simari, R. D., Stulak, J. M. & Lerman, A., 2015, (Accepted/In press) In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

9 Scopus citations

Muc1 is protective during kidney ischemia - Reperfusion injury

Pastor-Soler, N. M., Sutton, T. A., Mang, H. E., Kinlough, C. L., Gendler, S. J., Madsen, C. S., Bastacky, S. I., Ho, J., Al-Bataineh, M. M., Hallows, K. R., Singh, S., Monga, S. P., Kobayashi, H., Haase, V. H. & Hughey, R. P., Jun 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 12, p. F1452-F1462

Research output: Contribution to journalArticle

19 Scopus citations

Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Gaw, N., Dueck, A., Smith, K. A., Nakaji, P., Plasencia, J., Ranjbar, S., Price, S. J., Tran, N., Loftus, J. C., Jenkins, R. B., O'Neill, B. P., Elmquist, W., Baxter, L. C., Gao, F., Frakes, D., Karis, J. P., Zwart, C. & 5 others, Swanson, K., Sarkaria, J. N., Wu, T., Mitchell, J. R. & Li, J., Nov 1 2015, In : PLoS One. 10, 11, e0141506.

Research output: Contribution to journalArticle

49 Scopus citations

Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia

Rank, M. A., Ochkur, S. I., Lewis, J. C., Teaford, H. G., Wesselius, L. J., Helmers, R. A., Lee, N. A., Nair, P. & Lee, J. J., 2015, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

20 Scopus citations

Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease

Martin, L. J., Franciosi, J. P., Collins, M. H., Abonia, J. P., Lee, J. J., Hommel, K. A., Varni, J. W., Grotjan, J. T., Eby, M., He, H., Marsolo, K., Putnam, P. E., Garza, J. M., Kaul, A., Wen, T. & Rothenberg, M. E., Jun 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 6, p. 1519-1528e8

Research output: Contribution to journalArticle

51 Scopus citations

Pregnancy-associated plasma protein-A deficiency improves survival of mice on a high fat diet

Conover, C. A., Bale, L. K. & Marler, R. J., Oct 1 2015, In : Experimental Gerontology. 70, p. 131-134 4 p., 9677.

Research output: Contribution to journalArticle

4 Scopus citations

Recellularization of decellularized lung scaffolds is enhanced by dynamic suspension culture

Crabbé, A., Liu, Y., Sarker, S. F., Bonenfant, N. R., Barrila, J., Borg, Z. D., Lee, J. J., Weiss, D. J. & Nickerson, C. A., May 11 2015, In : PLoS One. 10, 5, e0126846.

Research output: Contribution to journalArticle

31 Scopus citations
2014

Activated mouse eosinophils protect against lethal respiratory virus infection

Percopo, C. M., Dyer, K. D., Ochkur, S. I., Luo, J. L., Fischer, E. R., Lee, J. J., Lee, N. A., Domachowske, J. B. & Rosenberg, H. F., Jan 30 2014, In : Blood. 123, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation

Mielke, C., Lefort, N., McLean, C. G., Cordova, J. M., Langlais, P. R., Bordner, A. J., Te, J. A., Ozkan, S. B., Willis, W. T. & Mandarino, L. J., Jun 17 2014, In : Biochemistry. 53, 23, p. 3817-3829 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Androgen receptor-positive triple negative breast cancer: A unique breast cancer subtype

McGhan, L. J., McCullough, A. E., Protheroe, C. A., Dueck, A. C., Lee, J. J., Nunez-Nateras, R., Castle, E. P., Gray, R. J., Wasif, N., Goetz, M. P., Hawse, J. R., Henry, T. J., Barrett, M. T., Cunliffe, H. E. & Pockaj, B. A., Feb 1 2014, In : Annals of surgical oncology. 21, 2, p. 361-367 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

A new formulation of protein evolutionary models that account for structural constraints

Bordner, A. J. & Mittelmann, H. D., Mar 2014, In : Molecular biology and evolution. 31, 3, p. 736-749 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment

Desai, A. J., Harikumar, K. G. & Miller, L. J., Jun 27 2014, In : Journal of Biological Chemistry. 289, 26, p. 18314-18326 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Changing roles of eosinophils in health and disease

Furuta, G. T., Atkins, F. D., Lee, N. A. & Lee, J. J., Jul 2014, In : Annals of Allergy, Asthma and Immunology. 113, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

51 Scopus citations

Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis

Schoepfer, A. M., Straumann, A., Panczak, R., Coslovsky, M., Kuehni, C. E., Maurer, E., Haas, N. A., Romero, Y., Hirano, I., Alexander, J. A., Gonsalves, N., Furuta, G. T., Dellon, E. S., Leung, J., Collins, M. H., Bussmann, C., Netzer, P., Gupta, S. K., Aceves, S. S., Chehade, M. & 46 others, Moawad, F. J., Enders, F. T., Yost, K. J., Taft, T. H., Kern, E., Zwahlen, M., Safroneeva, E., Achem, S. R., Arora, A. S., Alpan, O., Armstrong, D., Attwood, S. E., Butterfield, J. H., Crowell, M. D., De Petris, G., DeVault, K. R., Drouin, E., Enav, B., Fleischer, D. E., Foxx-Orenstein, A., Francis, D. L., Guyatt, G. H., Harris, L. A., Kagalwalla, A. F., Katzka, D. A., Kita, H., Krishna, M., Lee, J. J., Lewis, J. C., Lim, K., Locke, G. R., Murray, J. A., Nguyen, C. C., Orbelo, D. M., Pasha, S. F., Ramirez, F. C., Sheikh, J., Smyrk, T. C., Spergel, J. M., Umar, S. B., Weiler, C. R., Wo, J. M., Woosley, J. T., Wu, T. T., Yan, P. & Yang, G. Y., Dec 1 2014, In : Gastroenterology. 147, 6, p. 1255-1266.e21

Research output: Contribution to journalArticle

106 Scopus citations

Differential expression of microRNAs as predictors of glioblastoma phenotypes

Bradley, B. S., Loftus, J. C., Mielke, C. J. & Dinu, V., Jan 18 2014, In : BMC bioinformatics. 15, 1, 21.

Research output: Contribution to journalArticle

6 Scopus citations

Endoscopic band ligation for closure of GI perforations in a porcine animal model (with video)

Law, R., Deters, J. L., Miller, C. A., Marler, R. J. & Baron, T. H., Oct 1 2014, In : Gastrointestinal endoscopy. 80, 4, p. 717-722 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice

Jacobsen, E. A., LeSuer, W. E., Willetts, L., Zellner, K. R., Mazzolini, K., Antonios, N., Beck, B., Protheroe, C., Ochkur, S. I., Colbert, D., Lacy, P., Moqbel, R., Appleton, J., Lee, N. A. & Lee, J. J., Mar 1 2014, In : Allergy: European Journal of Allergy and Clinical Immunology. 69, 3, p. 315-327 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Eosinophil-derived IL-10 supports chronic nematode infection

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Lee, N. A., Lee, J. J. & Appleton, J. A., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4178-4187 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae

Cadman, E. T., Thysse, K. A., Bearder, S., Cheung, A. Y. N., Johnston, A. C., Lee, J. J. & Lawrence, R. A., Mar 2014, In : PLoS pathogens. 10, 3, e1003988.

Research output: Contribution to journalArticle

35 Scopus citations

Eosinophil shape change and secretion

Willetts, L., Ochkur, S. I., Jacobsen, E. A., Lee, J. J. & Lacy, P., 2014, Eosinophils: Methods and Protocols. Humana Press Inc., p. 111-128 18 p. (Methods in Molecular Biology; vol. 1178).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Eosinophils regulate peripheral B cell numbers in both mice and humans

Wong, T. W., Doyle, A. D., Lee, J. J. & Jelinek, D. F., Apr 15 2014, In : Journal of Immunology. 192, 8, p. 3548-3558 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease

Hickey, R. D., Mao, S. A., Glorioso, J., Lillegard, J. B., Fisher, J. E., Amiot, B., Rinaldo, P., Harding, C. O., Marler, R., Finegold, M. J., Grompe, M. & Nyberg, S. L., Jul 2014, In : Stem Cell Research. 13, 1, p. 144-153 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

Zhu, Y. X., Braggio, E., Shi, C. X., Kortuem, K. M., Bruins, L. A., Schmidt, J. E., Chang, X. B., Langlais, P., Luo, M., Jedlowski, P., LaPlant, B., Laumann, K., Fonseca, R., Bergsagel, P. L., Mikhael, J., Lacy, M., Champion, M. D. & Stewart, A. K., Jul 24 2014, In : Blood. 124, 4, p. 536-545 10 p.

Research output: Contribution to journalArticle

97 Scopus citations

Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUC1 tripartite vaccines modified by a TLR2 or TLR9 agonist

Abdel-Aal, A. B. M., Lakshminarayanan, V., Thompson, P., Supekar, N., Bradley, J. M., Wolfert, M. A., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jul 7 2014, In : ChemBioChem. 15, 10, p. 1508-1513 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression

Mills, L. D., Zhang, L., Marler, R., Svingen, P., Fernandez-Barrena, M. G., Dave, M., Bamlet, W., McWilliams, R. R., Petersen, G. M., Faubion, W. & Fernandez-Zapico, M. E., Jun 6 2014, In : Journal of Biological Chemistry. 289, 23, p. 16516-16525 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid t-cell sensitization and rejection of progressive tumor challenges

Hoelzinger, D. B., Dominguez, A. L., Cohen, P. A. & Gendler, S. J., Dec 1 2014, In : Cancer research. 74, 23, p. 6845-6855 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis

Masterson, J. C., McNamee, E. N., Hosford, L., Capocelli, K. E., Ruybal, J., Fillon, S. A., Doyle, A. D., Eltzschig, H. K., Rustgi, A. K., Protheroe, C. A., Lee, N. A., Lee, J. J. & Furuta, G. T., Jan 1 2014, In : Gut. 63, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma

Chang, X., Zhu, Y., Shi, C. & Stewart, A. K., Mar 1 2014, In : Acta Biochimica et Biophysica Sinica. 46, 3, p. 240-253 14 p.

Research output: Contribution to journalReview article

36 Scopus citations

Predicting response to bacillus Calmette-Guérin (BCG) in patients with carcinoma in situ of the bladder

Nunez-Nateras, R., Castle, E. P., Protheroe, C. A., Stanton, M. L., Ocal, T. I., Ferrigni, E. N., Ochkur, S. I., Jacobsen, E. A., Hou, Y. X., Andrews, P. E., Colby, T. V., Lee, N. A. & Lee, J. J., Jan 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 1, p. 45.e23-45.e30

Research output: Contribution to journalArticle

29 Scopus citations

Re-defining the unique roles for eosinophils in allergic respiratory inflammation

Jacobsen, E. A., Lee, N. A. & Lee, J. J., Sep 2014, In : Clinical and Experimental Allergy. 44, 9, p. 1119-1136 18 p.

Research output: Contribution to journalReview article

43 Scopus citations

Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β

Ogawa, H., Ledford, J. G., Mukherjee, S., Aono, Y., Nishioka, Y., Lee, J. J., Izumi, K. & Hollingsworth, J. W., Nov 29 2014, In : Respiratory Research. 15, 1, 143.

Research output: Contribution to journalArticle

7 Scopus citations