Biochemistry and Molecular Biology

Research Output

2003

Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA

Chappe, V., Hinkson, D. A., Zhu, T., Chang, X. B., Riordan, J. R. & Hanrahan, J. W., Apr 1 2003, In : Journal of Physiology. 548, 1, p. 39-52 14 p.

Research output: Contribution to journalReview article

62 Scopus citations

Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells

Xia, J., Tanaka, Y., Koido, S., Liu, C., Mukherjee, P., Gendler, S. J. & Gong, J., Feb 15 2003, In : Journal of Immunology. 170, 4, p. 1980-1986 7 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations

The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins

Gentzsch, M., Cui, L., Mengos, A., Chang, X. B., Chen, J. H. & Riordan, J. R., Feb 21 2003, In : Journal of Biological Chemistry. 278, 8, p. 6440-6449 10 p.

Research output: Contribution to journalArticle

108 Scopus citations
2002

Accurate transferable model for water, n-octanol, and n-hexadecane solvation free energies

Bordner, A. J., Cavasotto, C. N. & Abagyan, R. A., Oct 24 2002, In : Journal of Physical Chemistry B. 106, 42, p. 11009-11015 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes

Valencik, M. L., Keller, R. S., Loftus, J. C. & McDonald, J. A., Aug 2002, In : Journal of Cardiac Failure. 8, 4, p. 262-272 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Applications of fluorescence in the characterization of the ligand-binding domain and activation of the cholecystokinin receptor

Harikumar, K. G. & Miller, L. J., Dec 1 2002, In : Pharmacology and Toxicology. 91, 6, p. 286-289 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

A tale of two controversies. Defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species

Brennan, M. L., Wu, W., Fu, X., Shen, Z., Song, W., Frost, H., Vadseth, C., Narine, L., Lenkiewicz, E., Borchers, M. T., Lusis, A. J., Lee, J. J., Lee, N. A., Abu-Soud, H. M., Ischiropoulos, H. & Hazen, S. L., May 17 2002, In : Journal of Biological Chemistry. 277, 20, p. 17415-17427 13 p.

Research output: Contribution to journalArticle

430 Scopus citations

ATP binding to the first nucleotide-binding domain of multidrug resistance protein MRP1 increases binding and hydrolysis of ATP and trapping of ADP at the second domain

Hou, Y. X., Cui, L., Riordan, J. R. & Chang, X. B., Feb 15 2002, In : Journal of Biological Chemistry. 277, 7, p. 5110-5119 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Cardiac myocyte-specific excision of the β1 integrin gene results in myocardial fibrosis and cardiac failure

Shai, S. Y., Harpf, A. E., Babbitt, C. J., Jordan, M. C., Fishbein, M. C., Chen, J., Omura, M., Leil, T. A., Becker, K. D., Jiang, M., Smith, D. J., Cherry, S. R., Loftus, J. C. & Ross, R. S., Mar 8 2002, In : Circulation research. 90, 4, p. 458-464 7 p.

Research output: Contribution to journalArticle

217 Scopus citations

CD4+ T cell-dependent airway mucus production occurs in response to IL-5 expression in lung

Paul Justice, J., Crosby, J., Borchers, M. T., Tomkinson, A., Lee, J. J. & Lee, N. A., Jun 29 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 5 26-5, p. L1066-L1074

Research output: Contribution to journalArticle

40 Scopus citations

CFTR is a monomer: Biochemical and functional evidence

Chen, J. H., Chang, X. B., Aleksandrov, A. A. & Riordan, J. R., Jul 1 2002, In : Journal of Membrane Biology. 188, 1, p. 55-71 17 p.

Research output: Contribution to journalArticle

33 Scopus citations

Dendritic cell-tumor cell fusion and staphylococcal enterotoxin B treatment in a pancreatic tumor model

McConnell, E. J., Pathangey, L. B., Madsen, C. S., Gendler, S. J. & Mukherjee, P., Jan 1 2002, In : Journal of Surgical Research. 107, 2, p. 196-202 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Early phase bronchoconstriction in the mouse requires allergen-specific IgG

Crosby, J. R., Cieslewicz, G., Borchers, M., Hines, E., Carrigan, P., Lee, J. J. & Lee, N. A., Apr 15 2002, In : Journal of Immunology. 168, 8, p. 4050-4054 5 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Ectopic expression of IL-5 identifies an additional CD4+ T cell mechanism of airway eosinophil recruitment

Crosby, J. R., Shen, H. H., Borchers, M. T., Justice, J. P., Ansay, T., Lee, J. J. & Lee, N. A., Jun 29 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 1 26-1, p. L99-L108

Research output: Contribution to journalArticle

16 Scopus citations

Environment and mobility of a series of fluorescent reporters at the amino terminus of structurally related peptide agonists and antagonists bound to the cholecystokinin receptor

Harikumar, K. G., Pinon, D. I., Wessels, W. S., Prendergast, F. G. & Miller, L. J., May 24 2002, In : Journal of Biological Chemistry. 277, 21, p. 18552-18560 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

ErbB-β-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas

Schroeder, J. A., Adriance, M. C., McConnell, E. J., Thompson, M. C., Pockaj, B. & Gendler, S. J., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22692-22698 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Gq signaling is required for allergen-induced pulmonary eosinophilia

Borchers, M. T., Justice, P. J., Ansay, T., Mancino, V., McGarry, M. P., Crosby, J., Simon, M. I., Lee, N. A. & Lee, J. J., Apr 1 2002, In : Journal of Immunology. 168, 7, p. 3543-3549 7 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucα1-2 glycosyltransferase

Thomsson, K. A., Hinojosa-Kurtzberg, M., Axelsson, K. A., Domino, S. E., Lowe, J. B., Gendler, S. J. & Hansson, G. C., Nov 1 2002, In : Biochemical Journal. 367, 3, p. 609-616 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration

Borchers, M. T., Ansay, T., DeSalle, R., Daugherty, B. L., Shen, H., Metzger, M., Lee, N. A. & Lee, J. J., Jun 1 2002, In : Journal of Leukocyte Biology. 71, 6, p. 1033-1041 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

In vitro selection of fibronectin gain-of-function mutations

Tani, P. H., Loftus, J. C. & Bowditch, R. D., Jul 1 2002, In : Biochemical Journal. 365, 1, p. 287-294 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Many αIIbβ3 autoepitopes in chronic immune thrombocytopenic purpura are localized to αIIb between amino acids L1 and Q459

Mcmillan, R., Wang, L., Lopez-Dee, J., Jiu, S. & Loftus, J. C., Sep 25 2002, In : British journal of haematology. 118, 4, p. 1132-1136 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells

Wykes, M., MacDonald, K. P. A., Tran, M., Quin, R. J., Xing, P. X., Gendler, S. J., Hart, D. N. J. & McGuckin, M. A., Oct 1 2002, In : Journal of Leukocyte Biology. 72, 4, p. 692-701 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Muscle development and lineage-specific expression of CiMDF, the MyoD-family gene of Ciona intestinalis

Meedel, T. H., Lee, J. J. & Whittaker, J. R., Jan 15 2002, In : Developmental Biology. 241, 2, p. 238-246 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pulmonary pathologies in pallid mice result from nonhematopoietic defects

McGarry, M. P., Borchers, M., Novak, E. K., Lee, N. A., Ohtake, P. J., Lee, J. J. & Swank, R. T., Jan 1 2002, In : Experimental and Molecular Pathology. 72, 3, p. 213-220 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ragweed-induced expression of GATA-3, IL-4, and IL-5 by eosinophils in the lungs of allergic C57BL/6J mice

Paul Justice, J., Borchers, M. T., Lee, J. J., Rowan, W. H., Shibata, Y. & Van Scott, M. R., Jun 29 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 282, 2 26-2, p. L302-L309

Research output: Contribution to journalArticle

35 Scopus citations

Solubilization of high affinity G-protein-coupled serotonin1A receptors from bovine hippocampus using pre-micellar CHAPS at low concentration

Chattopadhyay, A., Harikumar, K. G. & Kalipatnapu, S., Jul 1 2002, In : Molecular Membrane Biology. 19, 3, p. 211-220 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

TH2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages

Cormier, S. A., Yuan, S., Crosby, J. R., Protheroe, C. A., Dimina, D. M., Hines, E. M., Lee, N. A. & Lee, J. J., Dec 1 2002, In : American journal of respiratory cell and molecular biology. 27, 6, p. 678-687 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

The first nucleotide binding domain of cystic fibrosis transmembrane conductance regulator is a site of stable nucleotide interaction, whereas the second is a site of rapid turnover

Aleksandrov, L., Aleksandrov, A. A., Chang, X. B. & Riordan, J. R., May 3 2002, In : Journal of Biological Chemistry. 277, 18, p. 15419-15425 7 p.

Research output: Contribution to journalArticle

152 Scopus citations
2001

Autoantibodies to αIIbβ3 in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on αIIb

McMillan, R., Lopez-Dee, J. & Loftus, J. C., Apr 1 2001, In : Blood. 97, 7, p. 2171-2172 2 p.

Research output: Contribution to journalArticle

22 Scopus citations

Blockade of CD49d inhibits allergic airway pathologies independent of effects on leukocyte recruitment

Borchers, M. T., Crosby, J., Farmer, S., Sypek, J., Ansay, T., Lee, N. A. & Lee, J. J., Apr 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 280, 4 24-4, p. L813-L821

Research output: Contribution to journalArticle

47 Scopus citations

Calogero-Moser models. V - Supersymmetry and quantum Lax pair -

Bordner, A. J., Manton, N. S. & Sasaki, R., Mar 2001, In : Progress of Theoretical Physics. 103, 3, p. 463-487 25 p.

Research output: Contribution to journalArticle

50 Scopus citations

Differential Interactions of Nucleotides at the Two Nucleotide Binding Domains of the Cystic Fibrosis Transmembrane Conductance Regulator

Aleksandrov, L., Mengos, A., Chang, X. B., Aleksandrov, A. & Riordan, J. R., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 12918-12923 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance

Keller, R. S., Shai, S. Y., Babbitt, C. J., Pham, C. G., Solaro, R. J., Valencik, M. L., Loftus, J. C. & Ross, R. S., Jan 1 2001, In : American Journal of Pathology. 158, 3, p. 1079-1090 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Early life of cystic fibrosis transmembrane conductance regulator (CFTR) in the cell

Riordan, J. R., Gentzsch, M., Hammerle, M., Chen, J. H., Mengos, A., Jensen, T. & Chang, X. B., Jan 1 2001, In : Kidney international. 60, 2, 1 p.

Research output: Contribution to journalArticle

Expression of IL-5 alters bone metabolism and induces ossification of the spleen in transgenic mice

Macias, M. P., Fitzpatrick, L. A., Brenneise, I., McGarry, M. P., Lee, J. J. & Lee, N. A., Jan 1 2001, In : Journal of Clinical Investigation. 107, 8, p. 949-959 11 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation

Denzler, K. L., Borchers, M. T., Crosby, J. R., Cieslewicz, G., Hines, E. M., Justice, J. P., Cormier, S. A., Lindenberger, K. A., Song, W., Wu, W., Hazen, S. L., Gleich, G. J., Lee, J. J. & Lee, N. A., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1672-1682 11 p.

Research output: Contribution to journalArticle

Open Access
101 Scopus citations

Influence of organ site and tumor cell type on MUC1-specific tumor immunity

Morikane, K., Tempero, R. M., Sivinski, C. L., Kitajima, S., Gendler, S. J. & Hollingsworth, M. A., Jan 1 2001, In : International Immunology. 13, 2, p. 233-240 8 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

Hauck, C. R., Sieg, D. J., Hsia, D. A., Loftus, J. C., Gaarde, W. A., Monia, B. P. & Schlaepfer, D. D., Oct 1 2001, In : Cancer research. 61, 19, p. 7079-7090 12 p.

Research output: Contribution to journalArticle

238 Scopus citations

Intrinsic AHR in IL-5 transgenic mice is dependent on C4+ cells and CD49d-mediated signaling

Borchers, M. T., Crosby, J., Justice, P., Farmer, S., Hines, E., Lee, J. J. & Lee, N. A., 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 3 25-3, p. L653-L659

Research output: Contribution to journalArticle

17 Scopus citations

Letter for Joyce

Gendler, S. J., Nov 1 2001, In : Glycoconjugate Journal. 18, 11-12, p. 839-840 2 p.

Research output: Contribution to journalLetter

Modulation of antagonist binding to serotonin1A receptors from bovine hippocampus by metal ions

Harikumar, K. G. & Chattopadhyay, A., Dec 1 2001, In : Cellular and molecular neurobiology. 21, 5, p. 453-464 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mouse eosinophil-associated ribonucleases: A unique subfamily expressed during hematopoiesis

Cormier, S. A., Larson, K. A., Yuan, S., Mitchell, T. L., Lindenberger, K., Carrigan, P., Lee, N. A. & Lee, J. J., May 22 2001, In : Mammalian Genome. 12, 5, p. 352-361 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

MUC1, The renaissance molecule

Gendler, S. J., Jul 1 2001, In : Journal of mammary gland biology and neoplasia. 6, 3, p. 339-353 15 p.

Research output: Contribution to journalReview article

407 Scopus citations

MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment

Mukherjee, P., Ginardi, A. R., Madsen, C. S., Tinder, T. L., Jacobs, F., Parker, J., Agrawal, B., Longenecker, B. M. & Gendler, S. J., Nov 1 2001, In : Glycoconjugate Journal. 18, 11-12, p. 931-942 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

MUC1-specific cytotoxic T lymphocytes eradicate tumors when adoptively transferred in vivo

Mukherjee, P., Ginardi, A. R., Tinder, T. L., Sterner, C. J. & Gendler, S. J., Mar 1 2001, In : Clinical Cancer Research. 7, 11 SUPPL., p. 848s-855s

Research output: Contribution to journalArticle

45 Scopus citations

Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation

Cui, L., Hou, Y. X., Riordan, J. R. & Chang, X. B., Aug 1 2001, In : Archives of Biochemistry and Biophysics. 392, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells

Manciu, L., Chang, X. B., Riordan, J. R., Buyse, F. & Ruysschaert, J. M., Mar 23 2001, In : FEBS Letters. 493, 1, p. 31-35 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pulmonary T cells and eosinophils: Coconspirators or independent triggers of allergic respiratory pathology?

Lee, N. A., Gelfand, E. W. & Lee, J. J., Jan 1 2001, In : Journal of Allergy and Clinical Immunology. 107, 6, p. 945-957 13 p.

Research output: Contribution to journalArticle

111 Scopus citations

Spontaneous adenocarcinoma mouse models for immunotherapy

Gendler, S. J. & Mukherjee, P., Jan 1 2001, In : Trends in Molecular Medicine. 7, 10, p. 471-475 5 p.

Research output: Contribution to journalReview article

21 Scopus citations

Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung

Takeda, K., Haczku, A., Lee, J. J., Irvin, C. G. & Gelfand, E. W., Jan 1 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 2 25-2, p. L394-L402

Research output: Contribution to journalArticle

117 Scopus citations