Biochemistry and Molecular Biology

Research Output 1993 2018

2002
38 Citations (Scopus)

Solubilization of high affinity G-protein-coupled serotonin1A receptors from bovine hippocampus using pre-micellar CHAPS at low concentration

Chattopadhyay, A., Harikumar, K. G. & Kalipatnapu, S., Jul 2002, In : Molecular Membrane Biology. 19, 3, p. 211-220 10 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT1A
G-Protein-Coupled Receptors
Hippocampus
GTP-Binding Proteins
Detergents
39 Citations (Scopus)

TH2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages

Cormier, S. A., Yuan, S., Crosby, J. R., Protheroe, C. A., Dimina, D. M., Hines, E. M., Lee, N. A. & Lee, J. J., Dec 1 2002, In : American Journal of Respiratory Cell and Molecular Biology. 27, 6, p. 678-687 10 p.

Research output: Contribution to journalArticle

Eosinophil Cationic Protein
Alveolar Macrophages
Ribonucleases
Pneumonia
Genes
152 Citations (Scopus)

The first nucleotide binding domain of cystic fibrosis transmembrane conductance regulator is a site of stable nucleotide interaction, whereas the second is a site of rapid turnover

Aleksandrov, L., Aleksandrov, A. A., Chang, X-B. D. & Riordan, J. R., May 3 2002, In : Journal of Biological Chemistry. 277, 18, p. 15419-15425 7 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Hydrolysis
Nucleotides
Adenylyl Imidodiphosphate
Adenine Nucleotides
2001
47 Citations (Scopus)

Blockade of CD49d inhibits allergic airway pathologies independent of effects on leukocyte recruitment

Borchers, M. T., Crosby, J., Farmer, S., Sypek, J., Ansay, T., Lee, N. A. & Lee, J. J., Apr 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 280, 4 24-4

Research output: Contribution to journalArticle

Eosinophils
Leukocytes
Lymphocytes
Pathology
Metaplasia
76 Citations (Scopus)

Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance

Keller, R. S., Shai, S. Y., Babbitt, C. J., Pham, C. G., Solaro, R. J., Valencik, M. L., Loftus, J. C. & Ross, R. S., 2001, In : American Journal of Pathology. 158, 3, p. 1079-1090 12 p.

Research output: Contribution to journalArticle

Integrins
Myocardium
Fibrosis
Transgenes
Transgenic Mice

Early life of cystic fibrosis transmembrane conductance regulator (CFTR) in the cell

Riordan, J. R., Gentzsch, M., Hammerle, M., Chen, J. H., Mengos, A., Jensen, T. & Chang, X-B. D., 2001, In : Kidney International. 60, 2, p. 401 1 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
46 Citations (Scopus)

Expression of IL-5 alters bone metabolism and induces ossification of the spleen in transgenic mice

Macias, M. P., Fitzpatrick, L. A., Brenneise, I., McGarry, M. P., Lee, J. J. & Lee, N. A., 2001, In : Journal of Clinical Investigation. 107, 8, p. 949-959 11 p.

Research output: Contribution to journalArticle

Interleukin-5
Osteogenesis
Transgenic Mice
Spleen
Bone and Bones
98 Citations (Scopus)

Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation

Denzler, K. L., Borchers, M. T., Crosby, J. R., Cieslewicz, G., Hines, E. M., Justice, J. P., Cormier, S. A., Lindenberger, K. A., Song, W., Wu, W., Hazen, S. L., Gleich, G. J., Lee, J. J. & Lee, N. A., Aug 1 2001, In : Journal of Immunology. 167, 3, p. 1672-1682 11 p.

Research output: Contribution to journalArticle

Eosinophil Peroxidase
Ovalbumin
Pneumonia
Lung
Asthma
16 Citations (Scopus)

Influence of organ site and tumor cell type on MUC1-specific tumor immunity

Morikane, K., Tempero, R. M., Sivinski, C. L., Kitajima, S., Gendler, S. J. & Hollingsworth, M. A., 2001, In : International Immunology. 13, 2, p. 233-240 8 p.

Research output: Contribution to journalArticle

Immunity
Pancreas
Neoplasms
Adoptive Transfer
Pancreatic Neoplasms
236 Citations (Scopus)

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

Hauck, C. R., Sieg, D. J., Hsia, D. A., Loftus, J. C., Gaarde, W. A., Monia, B. P. & Schlaepfer, D. D., Oct 1 2001, In : Cancer Research. 61, 19, p. 7079-7090 12 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Epidermal Growth Factor
Carcinoma
Cell Movement
Phosphotransferases
17 Citations (Scopus)

Intrinsic AHR in IL-5 transgenic mice is dependent on C4+ cells and CD49d-mediated signaling

Borchers, M. T., Crosby, J., Justice, P., Farmer, S., Hines, E., Lee, J. J. & Lee, N. A., 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 3 25-3

Research output: Contribution to journalArticle

Interleukin-5
Transgenic Mice
Eosinophils
Integrins
B-Lymphocytes

Letter for Joyce

Gendler, S. J., Nov 2001, In : Glycoconjugate Journal. 18, 11-12, p. 839-840 2 p.

Research output: Contribution to journalArticle

20th Century History
Glycosylation
Homeodomain Proteins
Mucin-1
Biochemistry
34 Citations (Scopus)

Mouse eosinophil-associated ribonucleases: A unique subfamily expressed during hematopoiesis

Cormier, S. A., Larson, K. A., Yuan, S., Mitchell, T. L., Lindenberger, K., Carrigan, P., Lee, N. A. & Lee, J. J., 2001, In : Mammalian Genome. 12, 5, p. 352-361 10 p.

Research output: Contribution to journalArticle

Eosinophil Cationic Protein
Pancreatic Ribonuclease
Hematopoiesis
Ribonucleases
Eosinophils
393 Citations (Scopus)

MUC1, The renaissance molecule

Gendler, S. J., Jul 2001, In : Journal of Mammary Gland Biology and Neoplasia. 6, 3, p. 339-353 15 p.

Research output: Contribution to journalArticle

Mucins
Lubrication
Proteins
Human Mammary Glands
Urinary Tract
48 Citations (Scopus)

MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment

Mukherjee, P., Ginardi, A. R., Madsen, C. S., Tinder, T. L., Jacobs, F., Parker, J., Agrawal, B., Longenecker, B. M. & Gendler, S. J., Nov 2001, In : Glycoconjugate Journal. 18, 11-12, p. 931-942 12 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Tumors
Pancreas
Neoplasms
Neoplasm Antigens
45 Citations (Scopus)

MUC1-specific cytotoxic T lymphocytes eradicate tumors when adoptively transferred in vivo

Mukherjee, P., Ginardi, A. R., Tinder, T. L., Sterner, C. J. & Gendler, S. J., Mar 2001, In : Clinical Cancer Research. 7, 11 SUPPL.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Neoplasms
Epitopes
Experimental Melanomas
Tandem Repeat Sequences
24 Citations (Scopus)

Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation

Cui, L., Hou, Y. X., Riordan, J. R. & Chang, X-B. D., Aug 1 2001, In : Archives of Biochemistry and Biophysics. 392, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Nucleotides
Mutation
Hydrolysis
Adenosine Triphosphate
19 Citations (Scopus)

Nucleotide-induced conformational changes in the human multidrug resistance protein MRP1 are related to the capacity of chemotherapeutic drugs to accumulate or not in resistant cells

Manciu, L., Chang, X-B. D., Riordan, J. R., Buyse, F. & Ruysschaert, J. M., Mar 23 2001, In : FEBS Letters. 493, 1, p. 31-35 5 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Daunorubicin
Doxorubicin
Nucleotides
Pharmaceutical Preparations
21 Citations (Scopus)

Spontaneous adenocarcinoma mouse models for immunotherapy

Gendler, S. J. & Mukherjee, P., 2001, In : Trends in Molecular Medicine. 7, 10, p. 471-475 5 p.

Research output: Contribution to journalArticle

Immunotherapy
Adenocarcinoma
Antigen Presentation
Neoplasms
Cancer Vaccines
116 Citations (Scopus)

Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung

Takeda, K., Haczku, A., Lee, J. J., Irvin, C. G. & Gelfand, E. W., 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 2 25-2

Research output: Contribution to journalArticle

Eosinophils
Lung
Inbred C57BL Mouse
Methacholine Chloride
Compliance
142 Citations (Scopus)

Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice

Tomkinson, A., Cieslewicz, G., Duez, C., Larson, K. A., Lee, J. J. & Gelfand, E. W., 2001, In : American Journal of Respiratory and Critical Care Medicine. 163, 3 I, p. 721-730 10 p.

Research output: Contribution to journalArticle

Ovalbumin
Bronchoalveolar Lavage Fluid
Eosinophilia
Interleukin-5
Eosinophils
267 Citations (Scopus)

Transgenic MUC1 Interacts with Epidermal Growth Factor Receptor and Correlates with Mitogen-activated Protein Kinase Activation in the Mouse Mammary Gland

Schroeder, J. A., Thompson, M. C., Gardner, M. M. & Gendler, S. J., Apr 20 2001, In : Journal of Biological Chemistry. 276, 16, p. 13057-13064 8 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Mitogen-Activated Protein Kinases
Immunoprecipitation
Epidermal Growth Factor Receptor
Carcinogenesis
57 Citations (Scopus)

Vaccination with allogeneic dendritic cells fused to carcinoma cells induces antitumor immunity in MUC1 transgenic mice

Tanaka, Y., Koido, S., Chen, D., Gendler, S. J., Kufe, D. & Gong, J., 2001, In : Clinical Immunology. 101, 2, p. 192-200 9 p.

Research output: Contribution to journalArticle

Dendritic Cells
Transgenic Mice
Immunity
Vaccination
Cell Fusion
2000
23 Citations (Scopus)

Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice

Klein, I. K., Ritland, S. R., Burgart, L. J., Ziesmer, S. C., Roche, P. C., Gendler, S. J. & Karnes, W. E., Apr 15 2000, In : Cancer Research. 60, 8, p. 2077-2080 4 p.

Research output: Contribution to journalArticle

Adenoma
Protein Kinase C
Isoenzymes
Nuclear Proteins
Epithelium
130 Citations (Scopus)

Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1

Hou, Y. X., Cui, L., Riordan, J. R. & Chang, X-B. D., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20280-20287 8 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Nucleotides
Adenosine Triphosphate
Adenine Nucleotides
Adenosine Diphosphate
9 Citations (Scopus)

A novel CFTR disease-associated mutation causes addition of an extra N-linked oligosaccharide

Hämmerle, M. M., Aleksandrov, A. A., Chang, X-B. D. & Riordan, J. R., 2000, In : Glycoconjugate Journal. 17, 11, p. 807-813 7 p.

Research output: Contribution to journalArticle

Oligosaccharides
Membranes
Mutation
Consensus Sequence
Calnexin
16 Citations (Scopus)

Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin α(IIb)β3: Further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery

Rahman, S., Flynn, G., Aitken, A., Patel, Y., Hussain, F., Lu, X., Loftus, J. C., French, D., Wijelath, E., Strand, K. & Savidge, G. F., Feb 1 2000, In : Biochemical Journal. 345, 3, p. 701-709 9 p.

Research output: Contribution to journalArticle

Snake Venoms
Integrins
Ligands
Proteins
Venoms
99 Citations (Scopus)

Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma

Denzler, K. L., Farmer, S. C., Crosby, J. R., Borchers, M., Cieslewicz, G., Larson, K. A., Cormier-Regard, S., Lee, N. A. & Lee, J. J., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5509-5517 9 p.

Research output: Contribution to journalArticle

Eosinophil Major Basic Protein
Methacholine Chloride
Respiratory Hypersensitivity
Allergens
Asthma
5 Citations (Scopus)

Immobilization of silver ions onto paramagnetic particles for binding and release of a biotin-labeled oligonucleotide

Ramírez-Vick, J. E., García, A. A. & Lee, J., Feb 16 2000, In : Reactive and Functional Polymers. 43, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

Oligonucleotides
Biotin
Silver
Immobilization
immobilization
16 Citations (Scopus)

Inhibition of epidermal growth factor receptor tyrosine kinase fails to suppress adenoma formation in Apc(Min) mice but induces duodenal injury

Ritland, S. R., Gendler, S. J., Burgart, L. J., Fry, D. W., Nelson, J. M., Bridges, A. J., Andress, L. & Karnes W.E., J., Sep 1 2000, In : Cancer Research. 60, 17, p. 4678-4681 4 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Adenoma
Protein-Tyrosine Kinases
Acrylamide
Wounds and Injuries
980 Citations (Scopus)

Ligand binding to integrins

Plow, E. F., Haas, T. A., Zhang, L., Loftus, J. C. & Smith, J. W., Jul 21 2000, In : Journal of Biological Chemistry. 275, 29, p. 21785-21788 4 p.

Research output: Contribution to journalArticle

Integrins
Animals
Binding Sites
Ligands
182 Citations (Scopus)

Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction

Blackburn, M. R., Volmer, J. B., Thrasher, J. L., Zhong, H., Crosby, J. R., Lee, J. J. & Kellems, R. E., Jul 17 2000, In : Journal of Experimental Medicine. 192, 2, p. 159-170 12 p.

Research output: Contribution to journalArticle

Airway Obstruction
Adenosine Deaminase
Pneumonia
Adenosine
Lung
75 Citations (Scopus)

Mice with spontaneous pancreatic cancer naturally develop MUC-1-specific CTLs that eradicate tumors when adoptively transferred

Mukherjee, P., Ginardi, A. R., Madsen, C. S., Sterner, C. J., Adriance, M. C., Tevethia, M. J. & Gendler, S. J., Sep 15 2000, In : Journal of Immunology. 165, 6, p. 3451-3460 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
Transgenic Mice
Acinar Cell Carcinoma
Immunodominant Epitopes
26 Citations (Scopus)

Multidrug resistance protein MRP1 reconstituted into lipid vesicles: Secondary structure and nucleotide-induced tertiary structure changes

Manciu, L., Chang, X-B. D., Riordan, J. R. & Ruysschaert, J. M., Oct 24 2000, In : Biochemistry. 39, 42, p. 13026-13033 8 p.

Research output: Contribution to journalArticle

P-Glycoproteins
Nucleotides
Lipids
Adenosine Triphosphate
Adenosine Diphosphate

Role of MUC1 in intestinal mucin accumulation in the CF mouse

Gendler, S. J., Hinojosa-Kurtzberg, M., Axelsson, K. A., Thomsson, K. A. & Hansson, G. C., 2000, In : Pediatric Pulmonology. 30, SUPPL. 20, p. 127 1 p.

Research output: Contribution to journalArticle

Mucins
49 Citations (Scopus)

Selection and characterization of MUC1-specific CD8+ T cells from MUC1 transgenic mice immunized with dendritic-carcinoma fusion cells

Gong, J., Apostolopoulos, V., Chen, D., Chen, H., Koido, S., Gendler, S. J., Mckenzie, I. F. & Kufe, D., 2000, In : Immunology. 101, 3, p. 316-324 9 p.

Research output: Contribution to journalArticle

Cell Fusion
Transgenic Mice
Major Histocompatibility Complex
Carcinoma
T-Lymphocytes
103 Citations (Scopus)

Striated muscle-specific β(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway

Pham, C. G., Harpf, A. E., Keller, R. S., Vu, H. T., Shai, S. Y., Loftus, J. C. & Ross, R. S., 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 6 48-6

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Striated Muscle
Cardiac Myocytes
Integrins
Adrenergic Agents
23 Citations (Scopus)

T cell suppression as a mechanism for tolerance to MUC1 antigen in MUC1 transgenic mice

Chen, D., Koido, S., Li, Y., Gendler, S. J. & Gong, J., 2000, In : Breast Cancer Research and Treatment. 60, 2, p. 107-115 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Immunization
T-Lymphocytes
Antigens
Neoplasm Antigens
62 Citations (Scopus)

The non-hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating

Aleksandrov, A. A., Chang, X-B. D., Aleksandrov, L. & Riordan, J. R., 2000, In : Journal of Physiology. 528, 2, p. 259-265 7 p.

Research output: Contribution to journalArticle

Ion Channel Gating
Cystic Fibrosis Transmembrane Conductance Regulator
Hydrolysis
Adenosine Triphosphate
Ligands
1999
29 Citations (Scopus)

A mutation in the α subunit of the platelet integrin α(IIb)β3 identifies a novel region important for ligand binding

Tozer, E. C., Baker, E. K., Ginsberg, M. H. & Loftus, J. C., Feb 1 1999, In : Blood. 93, 3, p. 918-924 7 p.

Research output: Contribution to journalArticle

Platelets
Integrins
Blood Platelets
Ligands
Mutation

Assembly and glycosylation of gel forming mucins: Implications for cystic fibrosis

Hansson, G. C., Axelsson, M. A. B., Asker, N., Johansson, M. E. V., Steel, D. M., Thomsson, K. A., Lindgren, K. A. S., Axelsson, K. A., Hinojosa-Kutzberg, M., Gendler, S. J., Nilsson, T. & Karlsson, N. G., Sep 1999, In : Pediatric Pulmonology. 28, SUPPL. 19, p. 142-143 2 p.

Research output: Contribution to journalArticle

Mucins
Glycosylation
Cystic Fibrosis
Gels
67 Citations (Scopus)

Bacterial conjunctivitis in Muc1 null mice

Kardon, R., Price, R. E., Julian, J., Lagow, E., Tseng, S. C. G., Gendler, S. J. & Carson, D. D., 1999, In : Investigative Ophthalmology and Visual Science. 40, 7, p. 1328-1335 8 p.

Research output: Contribution to journalArticle

Bacterial Conjunctivitis
Harderian Gland
Keratin-14
Wild Animals
Antibodies
92 Citations (Scopus)
Piroxicam
Chemoprevention
Adenoma
Non-Steroidal Anti-Inflammatory Agents
Neoplasms
39 Citations (Scopus)

Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: Lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse

Ritland, S. R., Leighton, J. A., Hirsch, R. E., Morrow, J. D., Weaver, A. L. & Gendler, S. J., Apr 1999, In : Clinical Cancer Research. 5, 4, p. 855-863 9 p.

Research output: Contribution to journalArticle

Adenomatous Polyps
Mesalamine
Chemoprevention
Neoplasms
Anti-Inflammatory Agents
276 Citations (Scopus)

Fundamental signals that regulate eosinophil homing to the gastrointestinal tract

Mishra, A., Hogan, S. P., Lee, J. J., Foster, P. S. & Rothenberg, M. E., Jun 1999, In : Journal of Clinical Investigation. 103, 12, p. 1719-1727 9 p.

Research output: Contribution to journalArticle

Eosinophils
Gastrointestinal Tract
Interleukin-5
Recombinases
Innate Immunity
61 Citations (Scopus)

Influence of phosphorylation by protein kinase A on CFTR at the cell surface and endoplasmic reticulum

Seibert, F. S., Chang, X-B. D., Aleksandrov, A. A., Clarke, D. M., Hanrahan, J. W. & Riordan, J. R., Dec 6 1999, In : Biochimica et Biophysica Acta - Biomembranes. 1461, 2, p. 275-283 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Endoplasmic Reticulum
Phosphoproteins
Chemical activation
19 Citations (Scopus)

Passively transferred anti-MUC1 antibodies cause neither autoimmune disorders nor immunity against transplanted tumors in MUC1 transgenic mice

Tempero, R. M., Rowse, G. J., Gendler, S. J. & Hollingsworth, M. A., Feb 4 1999, In : International Journal of Cancer. 80, 4, p. 595-599 5 p.

Research output: Contribution to journalArticle

Transgenic Mice
Anti-Idiotypic Antibodies
Immunity
Tandem Repeat Sequences
Immunoglobulin G
108 Citations (Scopus)

Removal of multiple arginine-framed trafficking signals overcomes misprocessing of ΔF508 CFTR present in most patients with cystic fibrosis

Chang, X-B. D., Cui, L., Hou, Y. X., Jensen, T. J., Aleksandrov, A. A., Mengos, A. & Riordan, J. R., Jul 1999, In : Molecular Cell. 4, 1, p. 137-142 6 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Endoplasmic Reticulum
Arginine
Quality Control
26 Citations (Scopus)

Soluble P-selectin glycoprotein ligand 1 inhibits ocular inflammation in a murine model of allergy

Strauss, E. C., Larson, K. A., Brenneise, I., Foster, C. S., Larsen, G. R., Lee, N. A. & Lee, J. J., 1999, In : Investigative Ophthalmology and Visual Science. 40, 7, p. 1336-1342 7 p.

Research output: Contribution to journalArticle

Hypersensitivity
Eosinophils
Inflammation
Pollen
Control Groups
173 Citations (Scopus)

The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration

Cieslewicz, G., Tomkinson, A., Adler, A., Duez, C., Schwarze, J., Takeda, K., Larson, K. A., Lee, J. J., Irvin, C. G. & Gelfand, E. W., Aug 1999, In : Journal of Clinical Investigation. 104, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

Interleukin-5
Eosinophils
Cromolyn Sodium
Ovalbumin
Lung