Biochemistry and Molecular Biology

Research Output

2008

Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis

Ahrens, R., Waddell, A., Seidu, L., Blanchard, C., Carey, R., Forbes, E., Lampinen, M., Wilson, T., Cohen, E., Stringer, K., Ballard, E., Munitz, A., Xu, H., Lee, N., Lee, J. J., Rothenberg, M. E., Denson, L. & Hogan, S. P., Nov 15 2008, In : Journal of Immunology. 181, 10, p. 7390-7399 10 p.

Research output: Contribution to journalArticle

Open Access
104 Scopus citations

Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy

Wehling-henricks, M., Sokolow, S., Lee, J. J., Myung, K. H., Villalta, S. A. & Tidball, J. G., Aug 1 2008, In : Human molecular genetics. 17, 15, p. 2280-2292 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Monitoring the state of cholecystokinin receptor oligomerization after ligand binding using decay of time-resolved fluorescence anisotropy

Harikumar, K. G. & Miller, L. J., Nov 2008, Neural Signaling Opportunities for Novel Diagnostic Approaches and Therapies. Blackwell Publishing Inc., p. 21-27 7 p. (Annals of the New York Academy of Sciences; vol. 1144).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

MUC1 mucin is a negative regulator of toll-like receptor signaling

Ueno, K., Koga, T., Kato, K., Golenbock, D. T., Gendler, S. J., Kai, H. & Kim, K. C., Mar 1 2008, In : American journal of respiratory cell and molecular biology. 38, 3, p. 263-268 6 p.

Research output: Contribution to journalArticle

111 Scopus citations

Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor

Harikumar, K. G., Morfis, M. M., Sexton, P. M. & Miller, L. J., Nov 1 2008, In : Journal of Molecular Neuroscience. 36, 1-3, p. 279-285 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Phosphorylation of MUC1 by met modulates interaction with p53 and MMP1 expression

Singh, P. K., Behrens, M. E., Eggers, J. P., Cerny, R. L., Bailey, J. M., Shanmugam, K., Gendler, S. J., Bennett, E. P. & Hollingsworth, M. A., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 26985-26995 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase

Ulrich, M., Petre, A., Youhnovski, N., Prömm, F., Schirle, M., Schumm, M., Pero, R. S., Doyle, A., Checkel, J., Kita, H., Thiyagarajan, N., Acharya, K. R., Schmid-Grendelmeier, P., Simon, H. U., Schwarz, H., Tsutsui, M., Shimokawa, H., Bellon, G., Lee, J. J., Przybylski, M. & 1 others, Döring, G., Oct 17 2008, In : Journal of Biological Chemistry. 283, 42, p. 28629-28640 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Predicting small ligand binding sites in proteins using backbone structure

Bordner, A. J., Dec 1 2008, In : Bioinformatics. 24, 24, p. 2865-2871 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo

Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J., Felts, S. J. & Pease, L. R., Sep 1 2008, In : Journal of Immunology. 181, 5, p. 3137-3147 11 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator

Chang, X. B., Mengos, A., Hou, Y. X., Cui, L., Jensen, T. J., Aleksandrov, A., Riordan, J. R. & Gentzsch, M., Sep 1 2008, In : Journal of cell science. 121, 17, p. 2814-2823 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Spontaneous vulvar papillomas in a colony of mice used for pancreatic cancer research

Gades, N. M., Ohashi, A., Mills, L. D., Rowley, M. A., Predmore, K. S., Marler, R. J. & Couch, F. J., Jun 1 2008, In : Comparative medicine. 58, 3, p. 271-275 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Structure and function of the cell surface (tethered) mucins

Hattrup, C. L. & Gendler, S. J., Jun 2 2008, In : Annual Review of Physiology. 70, p. 431-457 27 p.

Research output: Contribution to journalReview article

429 Scopus citations

The gastric mucus layers: Constituents and regulation of accumulation

Phillipson, M., Johansson, M. E. V., Henriksnäs, J., Petersson, J., Gendler, S. J., Sandler, S., Persson, A. E. G., Hansson, G. C. & Holm, L., Oct 1 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 4, p. G806-G812

Research output: Contribution to journalArticle

73 Scopus citations
6 Scopus citations

Use of multidimensional fluorescence resonance energy transfer to establish the orientation of cholecystokinin docked at the type A cholecystokinin receptor

Harikumar, K. G., Gao, F., Pinon, D. I. & Miller, L. J., Sep 9 2008, In : Biochemistry. 47, 36, p. 9574-9581 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2007

(R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1

Perrotton, T., Trompier, D., Chang, X. B., Di Pietro, A. & Baubichon-Cortay, H., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31542-31548 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1

Chang, X. B., Mar 1 2007, In : Cancer and Metastasis Reviews. 26, 1, p. 15-37 23 p.

Research output: Contribution to journalReview article

45 Scopus citations

An organizational laser safety program at Mayo Clinic in Arizona

Wesselius, L., Frederiksen, S., Walton, H., Pasquariello, T., Didehban, R., Fleeger, R., Friedman, L. & Harikumar, K., Dec 1 2007, International Laser Safety Conference: The World's Leading Conference on Laser Safety, ILSC 2007. p. 218-220 3 p. (International Laser Safety Conference: The World's Leading Conference on Laser Safety, ILSC 2007).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Biochemical and cell biological mechanisms of cholecystokinin receptor regulation

Miller, L. J., Dong, M., Harikumar, K. G. & Lisenbee, C. S., Jun 1 2007, In : Current Topics in Medicinal Chemistry. 7, 12, p. 1166-1172 7 p.

Research output: Contribution to journalReview article

7 Scopus citations

Characterization of the MUC1.Tg/MIN transgenic mouse as a model for studying antigen-specific immunotherapy of adenomas

Akporiaye, E. T., Bradley-Dunlop, D., Gendler, S. J., Mukherjee, P., Madsen, C. S., Hahn, T., Besselsen, D. G., Dial, S. M., Cui, H. & Trevor, K., Sep 28 2007, In : Vaccine. 25, 39-40, p. 6965-6974 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma

Ochkur, S. I., Jacobsen, E. A., Protheroe, C. A., Biechele, T. L., Pero, R. S., McGarry, M. P., Wang, H., O'Neill, K. R., Colbert, D. C., Colby, T. V., Shen, H., Blackburn, M. R., Irvin, C. C., Lee, J. J. & Lee, N. A., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 7879-7889 11 p.

Research output: Contribution to journalArticle

Open Access
116 Scopus citations

Domain Interdependence in the Biosynthetic Assembly of CFTR

Cui, L., Aleksandrov, L., Chang, X. B., Hou, Y. X., He, L., Hegedus, T., Gentzsch, M., Aleksandrov, A., Balch, W. E. & Riordan, J. R., Jan 26 2007, In : Journal of Molecular Biology. 365, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

153 Scopus citations

Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): Role in the inflammatory response within tumors

Lotfi, R., Lee, J. J. & Lotze, M. T., Jan 1 2007, In : Journal of Immunotherapy. 30, 1, p. 16-28 13 p.

Research output: Contribution to journalReview article

122 Scopus citations

Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation?

Jacobsen, E. A., Taranova, A. G., Lee, N. A. & Lee, J. J., Jun 1 2007, In : Journal of Allergy and Clinical Immunology. 119, 6, p. 1313-1320 8 p.

Research output: Contribution to journalArticle

152 Scopus citations

Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice

Padigel, U. M., Hess, J. A., Lee, J. J., Lok, J. B., Nolan, T. J., Schad, G. A. & Abraham, D., Dec 15 2007, In : Journal of Infectious Diseases. 196, 12, p. 1844-1851 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Eosinophils and asthma

Jacobsen, E. A., Ochkur, S. I., Lee, N. A. & Lee, J. J., Apr 1 2007, In : Current Allergy and Asthma Reports. 7, 1, p. 18-26 9 p.

Research output: Contribution to journalReview article

55 Scopus citations

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J. & Lötvall, J. O., Jun 1 2007, In : Nature Cell Biology. 9, 6, p. 654-659 6 p.

Research output: Contribution to journalArticle

6057 Scopus citations

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues

Harikumar, K. G., Lam, P. C. H., Dong, M., Sexton, P. M., Abagyan, R. & Miller, L. J., Nov 9 2007, In : Journal of Biological Chemistry. 282, 45, p. 32834-32843 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation

Pero, R. S., Borchers, M. T., Spicher, K., Ochkur, S. I., Sikora, L., Rao, S. P., Abdala-Valencia, H., O'Neill, K. R., Shen, H., McGarry, M. P., Lee, N. A., Cook-Mills, J. M., Sriramarao, P., Simon, M. I., Birnbaumer, L. & Lee, J. J., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4371-4376 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
8 Scopus citations

Identification of an alternative Gαq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes

Shi, G., Partida-Sánchez, S., Misra, R. S., Tighe, M., Borchers, M. T., Lee, J. J., Simon, M. I. & Lund, F. E., Oct 29 2007, In : Journal of Experimental Medicine. 204, 11, p. 2705-2718 14 p.

Research output: Contribution to journalArticle

61 Scopus citations

Intraocular use of rituximab

Kitzmann, A. S., Pulido, J. S., Mohney, B. G., Baratz, K. H., Grube, T., Marler, R. J., Donaldson, M. J., O'Neill, B. P., Johnston, P. B., Johnson, K. M., Dixon, L. E., Salomao, D. R. & Cameron, J. D., Dec 2007, In : Eye. 21, 12, p. 1524-1527 4 p.

Research output: Contribution to journalArticle

68 Scopus citations
4 Scopus citations

Misassembled mutant ΔF508 CFTR in the distal secretory pathway alters cellular lipid trafficking

Gentzsch, M., Choudhury, A., Chang, X. B., Pagano, R. E. & Riordan, J. R., Feb 1 2007, In : Journal of cell science. 120, 3, p. 447-455 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

McAuley, J. L., Linden, S. K., Chin, W. P., King, R. M., Pennington, H. L., Gendler, S. J., Florin, T. H., Hill, G. R., Korolik, V. & McGuckin, M. A., Aug 1 2007, In : Journal of Clinical Investigation. 117, 8, p. 2313-2324 12 p.

Research output: Contribution to journalArticle

243 Scopus citations

MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model

Mukherjee, P., Pathangey, L. B., Bradley, J. B., Tinder, T. L., Basu, G. D., Akporiaye, E. T. & Gendler, S. J., Feb 19 2007, In : Vaccine. 25, 9, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

Multidrug resistance protein 1 is not associated to detergent-resistant membranes

Cerf, E., Gasper, R., Rychnovsky, S., Chang, X. B., Buyse, F. & Ruysschaert, J. M., Apr 20 2007, In : Biochemical and Biophysical Research Communications. 355, 4, p. 1025-1030 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Platelet-derived growth factor receptor β-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells

Singh, P. K., Wen, Y., Swanson, B. J., Shanmugam, K., Kazlauskas, A., Cerny, R. L., Gendler, S. J. & Hollingsworth, M. A., Jun 1 2007, In : Cancer research. 67, 11, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

88 Scopus citations

Protein docking using surface matching and supervised machine learning

Bordner, A. J. & Gorin, A. A., Aug 1 2007, In : Proteins: Structure, Function and Genetics. 68, 2, p. 488-502 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Signaling through Gαi2 protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice

Padigel, U. M., Stein, L., Redding, K., Lee, J. J., Nolan, T. J., Schad, G. A., Birnbaumer, L. & Abraham, D., Apr 1 2007, In : Journal of Leukocyte Biology. 81, 4, p. 1120-1126 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor

Miller, L. J., Dong, M., Harikumar, K. G. & Gao, F., Aug 2007, In : Biochemical Society Transactions. 35, 4, p. 709-712 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Submucosal endoscopy with mucosal flap safety valve

Sumiyama, K., Gostout, C. J., Rajan, E., Bakken, T. A., Knipschield, M. A. & Marler, R. J., Apr 1 2007, In : Gastrointestinal endoscopy. 65, 4, p. 688-694 7 p.

Research output: Contribution to journalArticle

154 Scopus citations

Summary of the first international gastrointestinal eosinophil research symposium

Liacouras, C. A., Bonis, P., Putnam, P. E., Straumann, A., Ruchelli, E., Gupta, S. K., Lee, J. J., Hogan, S. P., Wershil, B. K., Rothenberg, M. E., Ackerman, S. J., Gomes, I., Murch, S., Mishra, A. & Furuta, G. T., Sep 1 2007, In : Journal of pediatric gastroenterology and nutrition. 45, 3, p. 370-391 22 p.

Research output: Contribution to journalArticle

32 Scopus citations

Transmembrane segment IV contributes a functionally important interface for oligomerization of the class II G protein-coupled secretin receptor

Harikumar, K. G., Pinon, D. I. & Miller, L. J., Oct 19 2007, In : Journal of Biological Chemistry. 282, 42, p. 30363-30372 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

When is a mouse basophil not a basophil?

Lee, J. J. & McGarry, M. P., Feb 1 2007, In : Blood. 109, 3, p. 859-861 3 p.

Research output: Contribution to journalReview article

43 Scopus citations
2006

Ab initio prediction of peptide-MHC binding geometry for diverse class I MHC allotypes

Bordner, A. J. & Abagyan, R., May 15 2006, In : Proteins: Structure, Function and Genetics. 63, 3, p. 512-526 15 p.

Research output: Contribution to journalArticle

63 Scopus citations

Absence of Histologic Retinal Toxicity of Intravitreal Bevacizumab in a Rabbit Model

Bakri, S. J., Cameron, J. D., McCannel, C. A., Pulido, J. S. & Marler, R. J., Jul 1 2006, In : American journal of ophthalmology. 142, 1, p. 162-164 3 p.

Research output: Contribution to journalArticle

97 Scopus citations

Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Jun 2006, In : Human gene therapy. 17, 6, p. 661-668 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Bringing molecular biology to bear on adhesion prevention: Postsurgical adhesion reduction using intraperitoneal inoculation of hyaluronic acid-inducing adenoviral vector in a murine model

Hammer, R. A., Morse, A. N., Cornella, J. L., Keller, R. S., Hentz, J., McDonald, J. A. & Loftus, J. C., Mar 1 2006, In : Journal of Gynecologic Surgery. 22, 1, p. 7-18 12 p.

Research output: Contribution to journalArticle

CD69 expression on airway eosinophils and airway inflammation in a murine model of asthma

Wang, H. Y., Shen, H. H., Lee, J. J. & Lee, N. A., Dec 5 2006, In : Chinese medical journal. 119, 23, p. 1983-1990 8 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations