Biochemistry and Molecular Biology

Research Output 1993 2019

2008
36 Citations (Scopus)

Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase

Ulrich, M., Petre, A., Youhnovski, N., Prömm, F., Schirle, M., Schumm, M., Pero, R. S., Doyle, A., Checkel, J., Kita, H., Thiyagarajan, N., Acharya, K. R., Schmid-Grendelmeier, P., Simon, H. U., Schwarz, H., Tsutsui, M., Shimokawa, H., Bellon, G., Lee, J. J., Przybylski, M. & 1 others, Döring, G., Oct 17 2008, In : Journal of Biological Chemistry. 283, 42, p. 28629-28640 12 p.

Research output: Contribution to journalArticle

Eosinophil Peroxidase
Nitration
Eosinophils
Tyrosine
Eosinophil-Derived Neurotoxin
37 Citations (Scopus)

Predicting small ligand binding sites in proteins using backbone structure

Bordner, A. J., Dec 2008, In : Bioinformatics. 24, 24, p. 2865-2871 7 p.

Research output: Contribution to journalArticle

Binding sites
Backbone
Binding Sites
Ligands
Proteins
98 Citations (Scopus)

Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo

Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J., Felts, S. J. & Pease, L. R., Sep 1 2008, In : Journal of Immunology. 181, 5, p. 3137-3147 11 p.

Research output: Contribution to journalArticle

Interleukin-17
Regulatory T-Lymphocytes
Dendritic Cells
T-Lymphocytes
Antigens
52 Citations (Scopus)

Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator

Chang, X-B. D., Mengos, A., Hou, Y. X., Cui, L., Jensen, T. J., Aleksandrov, A., Riordan, J. R. & Gentzsch, M., Sep 1 2008, In : Journal of Cell Science. 121, 17, p. 2814-2823 10 p.

Research output: Contribution to journalArticle

Oligosaccharides
Glycosylation
Cystic Fibrosis
Chloride Channels
Membranes
8 Citations (Scopus)

Spontaneous vulvar papillomas in a colony of mice used for pancreatic cancer research

Gades, N. M., Ohashi, A., Mills, L. D., Rowley, M. A., Predmore, K. S., Marler, R. J. & Couch, F. J., Jun 2008, In : Comparative Medicine. 58, 3, p. 271-275 5 p.

Research output: Contribution to journalArticle

pancreatic neoplasms
papilloma
Papilloma
Pancreatic Neoplasms
Bacteriology
413 Citations (Scopus)

Structure and function of the cell surface (tethered) mucins

Hattrup, C. L. & Gendler, S. J., 2008, In : Annual Review of Physiology. 70, p. 431-457 27 p.

Research output: Contribution to journalArticle

Mucins
Respiratory System
Lung Diseases
Glycoproteins
Epithelium
73 Citations (Scopus)

The gastric mucus layers: Constituents and regulation of accumulation

Phillipson, M., Johansson, M. E. V., Henriksnäs, J., Petersson, J., Gendler, S. J., Sandler, S., Persson, A. E. G., Hansson, G. C. & Holm, L., Oct 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 4

Research output: Contribution to journalArticle

Mucus
Stomach
Nitric Oxide Synthase Type II
Gastric Mucosa
Mucins
6 Citations (Scopus)
P-Glycoproteins
Protein folding
Protein Folding
Hydroxyl Radical
Adenosine Triphosphate
8 Citations (Scopus)

Use of multidimensional fluorescence resonance energy transfer to establish the orientation of cholecystokinin docked at the type A cholecystokinin receptor

Harikumar, K. G., Gao, F., Pinon, D. I. & Miller, L. J., Sep 9 2008, In : Biochemistry. 47, 36, p. 9574-9581 8 p.

Research output: Contribution to journalArticle

Cholecystokinin A Receptor
Fluorescence Resonance Energy Transfer
Cholecystokinin
Ligands
Cholecystokinin Receptors
2007
46 Citations (Scopus)

(R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1

Perrotton, T., Trompier, D., Chang, X-B. D., Di Pietro, A. & Baubichon-Cortay, H., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31542-31548 7 p.

Research output: Contribution to journalArticle

Verapamil
Isomers
Enantiomers
Cricetinae
Glutathione
44 Citations (Scopus)

A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1

Chang, X-B. D., Mar 2007, In : Cancer and Metastasis Reviews. 26, 1, p. 15-37 23 p.

Research output: Contribution to journalArticle

Multidrug Resistance-Associated Proteins
Multiple Drug Resistance
Adenosine Triphosphate
Pharmaceutical Preparations
Neoplasms

An organizational laser safety program at Mayo Clinic in Arizona

Wesselius, L., Frederiksen, S., Walton, H., Pasquariello, T., Didehban, R., Fleeger, R., Friedman, L. & Harikumar, K., 2007, International Laser Safety Conference: The World's Leading Conference on Laser Safety, ILSC 2007. p. 218-220 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Laser safety
Launching
Marketing
Feedback
Radiation
7 Citations (Scopus)

Biochemical and cell biological mechanisms of cholecystokinin receptor regulation

Miller, L. J., Dong, M., Harikumar, K. G. & Lisenbee, C. S., Jun 2007, In : Current Topics in Medicinal Chemistry. 7, 12, p. 1166-1172 7 p.

Research output: Contribution to journalArticle

Cholecystokinin Receptors
Cell membranes
Clathrin
Phosphorylation
Cell Membrane
11 Citations (Scopus)

Characterization of the MUC1.Tg/MIN transgenic mouse as a model for studying antigen-specific immunotherapy of adenomas

Akporiaye, E. T., Bradley-Dunlop, D., Gendler, S. J., Mukherjee, P., Madsen, C. S., Hahn, T., Besselsen, D. G., Dial, S. M., Cui, H. & Trevor, K., Sep 28 2007, In : Vaccine. 25, 39-40, p. 6965-6974 10 p.

Research output: Contribution to journalArticle

adenoma
immunotherapy
Adenoma
Immunotherapy
Transgenic Mice
112 Citations (Scopus)

Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma

Ochkur, S. I., Jacobsen, E., Protheroe, C. A., Biechele, T. L., Pero, R. S., McGarry, M. P., Wang, H., O'Neill, K. R., Colbert, D. C., Colby, T. V., Shen, H., Blackburn, M. R., Irvin, C. C., Lee, J. J. & Lee, N. A., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 7879-7889 11 p.

Research output: Contribution to journalArticle

Chemokine CCL24
Interleukin-5
Eosinophils
Asthma
Pathology
153 Citations (Scopus)

Domain Interdependence in the Biosynthetic Assembly of CFTR

Cui, L., Aleksandrov, L., Chang, X-B. D., Hou, Y. X., He, L., Hegedus, T., Gentzsch, M., Aleksandrov, A., Balch, W. E. & Riordan, J. R., Jan 26 2007, In : Journal of Molecular Biology. 365, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Cystic Fibrosis Transmembrane Conductance Regulator
Nucleotides
Quality Control
Mutation
118 Citations (Scopus)

Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): Role in the inflammatory response within tumors

Lotfi, R., Lee, J. J. & Lotze, M. T., Jan 2007, In : Journal of Immunotherapy. 30, 1, p. 16-28 13 p.

Research output: Contribution to journalArticle

Granulocytes
Neoplasms
Eosinophils
Eosinophilia
Alarmins
150 Citations (Scopus)

Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation?

Jacobsen, E., Taranova, A. G., Lee, N. A. & Lee, J. J., Jun 2007, In : Journal of Allergy and Clinical Immunology. 119, 6, p. 1313-1320 8 p.

Research output: Contribution to journalArticle

Eosinophils
Helminths
Caricatures
Graft Rejection
Adaptive Immunity
67 Citations (Scopus)

Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice

Padigel, U. M., Hess, J. A., Lee, J. J., Lok, J. B., Nolan, T. J., Schad, G. A. & Abraham, D., Dec 15 2007, In : Journal of Infectious Diseases. 196, 12, p. 1844-1851 8 p.

Research output: Contribution to journalArticle

Strongyloides stercoralis
Antigen-Presenting Cells
Eosinophils
Immunity
Antigens
55 Citations (Scopus)

Eosinophils and asthma

Jacobsen, E., Ochkur, S. I., Lee, N. A. & Lee, J. J., Apr 2007, In : Current Allergy and Asthma Reports. 7, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

Eosinophils
Asthma
Lung
Cell Communication
Reactive Oxygen Species
5662 Citations (Scopus)

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J. & Lötvall, J. O., Jun 2007, In : Nature Cell Biology. 9, 6, p. 654-659 6 p.

Research output: Contribution to journalArticle

Exosomes
MicroRNAs
RNA
Mast Cells
Messenger RNA
25 Citations (Scopus)

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues

Harikumar, K. G., Lam, P. C. H., Dong, M., Sexton, P. M., Abagyan, R. & Miller, L. J., Nov 9 2007, In : Journal of Biological Chemistry. 282, 45, p. 32834-32843 10 p.

Research output: Contribution to journalArticle

Fluorescence Resonance Energy Transfer
Secretin
G-Protein-Coupled Receptors
Nuclear magnetic resonance
Ligands
46 Citations (Scopus)

i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation

Pero, R. S., Borchers, M. T., Spicher, K., Ochkur, S. I., Sikora, L., Rao, S. P., Abdala-Valencia, H., O'Neill, K. R., Shen, H., McGarry, M. P., Lee, N. A., Cook-Mills, J. M., Sriramarao, P., Simon, M. I., Birnbaumer, L. & Lee, J. J., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4371-4376 6 p.

Research output: Contribution to journalArticle

Endothelium
Leukocytes
Vascular Endothelium
Endothelial Cells
Transendothelial and Transepithelial Migration
8 Citations (Scopus)
P-Glycoproteins
Solute transport
Hydrogen
Hydrogen bonds
Nucleotides
60 Citations (Scopus)

Identification of an alternative Gαq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes

Shi, G., Partida-Sánchez, S., Misra, R. S., Tighe, M., Borchers, M. T., Lee, J. J., Simon, M. I. & Lund, F. E., Oct 29 2007, In : Journal of Experimental Medicine. 204, 11, p. 2705-2718 14 p.

Research output: Contribution to journalArticle

Chemokine Receptors
Granulocytes
Dendritic Cells
Signal Transduction
Neutrophils
67 Citations (Scopus)

Intraocular use of rituximab

Kitzmann, A. S., Pulido, J. S., Mohney, B. G., Baratz, K., Grube, T., Marler, R. J., Donaldson, M. J., O'Neill, B. P., Johnston, P. B., Johnson, K. M., Dixon, L. E., Salomao, D. R. & Cameron, J. D., Dec 2007, In : Eye. 21, 12, p. 1524-1527 4 p.

Research output: Contribution to journalArticle

Rabbits
Injections
Intraocular Lymphoma
Rituximab
Light
4 Citations (Scopus)
Fluorescence Resonance Energy Transfer
Secretin
G-Protein-Coupled Receptors
Molecular Structure
Proteins
47 Citations (Scopus)

Misassembled mutant ΔF508 CFTR in the distal secretory pathway alters cellular lipid trafficking

Gentzsch, M., Choudhury, A., Chang, X-B. D., Pagano, R. E. & Riordan, J. R., Feb 1 2007, In : Journal of Cell Science. 120, 3, p. 447-455 9 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Secretory Pathway
Cholesterol
Lipids
Endoplasmic Reticulum
233 Citations (Scopus)

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

McAuley, J. L., Linden, S. K., Chin, W. P., King, R. M., Pennington, H. L., Gendler, S. J., Florin, T. H., Hill, G. R., Korolik, V. & McGuckin, M. A., Aug 1 2007, In : Journal of Clinical Investigation. 117, 8, p. 2313-2324 12 p.

Research output: Contribution to journalArticle

Mucin-1
Mucins
Campylobacter jejuni
Infection
Radiation Chimera
52 Citations (Scopus)

MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model

Mukherjee, P., Pathangey, L. B., Bradley, J. B., Tinder, T. L., Basu, G. D., Akporiaye, E. T. & Gendler, S. J., Feb 19 2007, In : Vaccine. 25, 9, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

colorectal neoplasms
Colonic Neoplasms
Vaccines
vaccines
therapeutics
10 Citations (Scopus)

Multidrug resistance protein 1 is not associated to detergent-resistant membranes

Cerf, E., Gasper, R., Rychnovsky, S., Chang, X-B. D., Buyse, F. & Ruysschaert, J. M., Apr 20 2007, In : Biochemical and Biophysical Research Communications. 355, 4, p. 1025-1030 6 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Detergents
Cholesterol
Membranes
Adenosine Triphosphate
85 Citations (Scopus)

Platelet-derived growth factor receptor β-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells

Singh, P. K., Wen, Y., Swanson, B. J., Shanmugam, K., Kazlauskas, A., Cerny, R. L., Gendler, S. J. & Hollingsworth, M. A., Jun 1 2007, In : Cancer Research. 67, 11, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Adenocarcinoma
Phosphorylation
Tail
Tyrosine
16 Citations (Scopus)

Signaling through Gαi2 protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice

Padigel, U. M., Stein, L., Redding, K., Lee, J. J., Nolan, T. J., Schad, G. A., Birnbaumer, L. & Abraham, D., Apr 2007, In : Journal of Leukocyte Biology. 81, 4, p. 1120-1126 7 p.

Research output: Contribution to journalArticle

Strongyloides stercoralis
Neutrophil Infiltration
Antibodies
Proteins
Larva
24 Citations (Scopus)

Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor

Miller, L. J., Dong, M., Harikumar, K. G. & Gao, F., Aug 2007, In : Biochemical Society Transactions. 35, 4, p. 709-712 4 p.

Research output: Contribution to journalArticle

Secretin
G-Protein-Coupled Receptors
GTP-Binding Proteins
Chemical activation
Ligands
152 Citations (Scopus)

Submucosal endoscopy with mucosal flap safety valve

Sumiyama, K., Gostout, C. J., Rajan, E., Bakken, T. A., Knipschield, M. A. & Marler, R. J., Apr 2007, In : Gastrointestinal Endoscopy. 65, 4, p. 688-694 7 p.

Research output: Contribution to journalArticle

Endoscopy
Stomach
Peritoneal Cavity
Safety
Swine
31 Citations (Scopus)

Summary of the first international gastrointestinal eosinophil research symposium

Liacouras, C. A., Bonis, P., Putnam, P. E., Straumann, A., Ruchelli, E., Gupta, S. K., Lee, J. J., Hogan, S. P., Wershil, B. K., Rothenberg, M. E., Ackerman, S. J., Gomes, I., Murch, S., Mishra, A. & Furuta, G. T., Sep 2007, In : Journal of Pediatric Gastroenterology and Nutrition. 45, 3, p. 370-391 22 p.

Research output: Contribution to journalArticle

eosinophils
Eosinophils
eosinophilia
endpoints
Research
72 Citations (Scopus)

Transmembrane segment IV contributes a functionally important interface for oligomerization of the class II G protein-coupled secretin receptor

Harikumar, K. G., Pinon, D. I. & Miller, L. J., Oct 19 2007, In : Journal of Biological Chemistry. 282, 42, p. 30363-30372 10 p.

Research output: Contribution to journalArticle

Oligomerization
G-Protein-Coupled Receptors
GTP-Binding Proteins
Secretin
Energy Transfer
43 Citations (Scopus)

When is a mouse basophil not a basophil?

Lee, J. J. & McGarry, M. P., Feb 1 2007, In : Blood. 109, 3, p. 859-861 3 p.

Research output: Contribution to journalArticle

Basophils
Flow cytometry
Publications
Flow Cytometry
Leukocytes
2006
97 Citations (Scopus)

Absence of Histologic Retinal Toxicity of Intravitreal Bevacizumab in a Rabbit Model

Bakri, S. J., Cameron, J. D., McCannel, C. A., Pulido, J. S. & Marler, R. J., Jul 2006, In : American Journal of Ophthalmology. 142, 1, p. 162-164 3 p.

Research output: Contribution to journalArticle

Rabbits
Microscopy
Optic Nerve
Light
Autolysis
53 Citations (Scopus)

Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors

Dwyer, R. M., Bergert, E. R., O'Connor, M. K., Gendler, S. J. & Morris, J. C., Jun 2006, In : Human Gene Therapy. 17, 6, p. 661-668 8 p.

Research output: Contribution to journalArticle

Adenoviridae
Iodides
Mucin-1
Pancreatic Neoplasms
Neoplasms

Bringing molecular biology to bear on adhesion prevention: Postsurgical adhesion reduction using intraperitoneal inoculation of hyaluronic acid-inducing adenoviral vector in a murine model

Hammer, R. A., Morse, A. N., Cornella, J. L., Keller, R. S., Hentz, J., McDonald, J. A. & Loftus, J. C., Mar 2006, In : Journal of Gynecologic Surgery. 22, 1, p. 7-18 12 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Molecular Biology
Adenoviridae
Nonparametric Statistics
Genetic Therapy
7 Citations (Scopus)

CD69 expression on airway eosinophils and airway inflammation in a murine model of asthma

Wang, H. Y., Shen, H. H., Lee, J. J. & Lee, N. A., Dec 5 2006, In : Chinese Medical Journal. 119, 23, p. 1983-1990 8 p.

Research output: Contribution to journalArticle

Eosinophils
Asthma
Inflammation
Interleukin-5
Mucus
54 Citations (Scopus)

Constitutive formation of oligomeric complexes between family B G protein-coupled vasoactive intestinal polypeptide and secretin receptors

Harikumar, K. G., Morfis, M. M., Lisenbee, C. S., Sexton, P. M. & Miller, L. J., Jan 2006, In : Molecular Pharmacology. 69, 1, p. 363-373 11 p.

Research output: Contribution to journalArticle

Vasoactive Intestinal Peptide
GTP-Binding Proteins
Receptors, Vasoactive Intestinal Peptide, Type II
Receptors, Vasoactive Intestinal Polypeptide, Type I
Energy Transfer
20 Citations (Scopus)

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

Lipinski, C. A., Tran, N., Dooley, A., Pang, Y-P., Rohl, C., Kloss, J., Yang, Z., McDonough, W., Craig, D., Berens, M. E. & Loftus, J. C., Oct 27 2006, In : Biochemical and Biophysical Research Communications. 349, 3, p. 939-947 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Glioma
Cell Movement
Mutagenesis
Chemotherapy
96 Citations (Scopus)

Cutting edge: Enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice

Lu, W., Hisatsune, A., Koga, T., Kato, K., Kuwahara, I., Lillehoj, E. P., Chen, W., Cross, A. S., Gendler, S. J., Gewirtz, A. T. & Kim, K. C., Apr 1 2006, In : Journal of Immunology. 176, 7, p. 3890-3894 5 p.

Research output: Contribution to journalArticle

Flagellin
Knockout Mice
Pseudomonas aeruginosa
Lung
Interleukin-8
112 Citations (Scopus)

Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis

Padigel, U. M., Lee, J. J., Nolan, T. J., Schad, G. A. & Abraham, D., Jun 2006, In : Infection and Immunity. 74, 6, p. 3232-3238 7 p.

Research output: Contribution to journalArticle

Strongyloides stercoralis
Antigen-Presenting Cells
Eosinophils
Antigens
T-Lymphocytes
24 Citations (Scopus)

Evidence That Gallbladder Epithelial Mucin Enhances Cholesterol Cholelithogenesis in MUC1 Transgenic Mice

Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Jul 2006, In : Gastroenterology. 131, 1, p. 210-222 13 p.

Research output: Contribution to journalArticle

Mucin-1
Mucins
Gallbladder
Transgenic Mice
Cholesterol
47 Citations (Scopus)

F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive

Hegedus, T., Aleksandrov, A., Cui, L., Gentzsch, M., Chang, X-B. D. & Riordan, J. R., May 2006, In : Biochimica et Biophysica Acta - Biomembranes. 1758, 5, p. 565-572 8 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Endoplasmic Reticulum
Quality Control
Quality control
Chloride Channels
3 Citations (Scopus)

Fluorescence characteristics of hydrophobic partial agonist probes of the cholecystokinin receptor

Harikumar, K. G., Pinon, D. I. & Miller, L. J., Apr 2006, In : Bioscience Reports. 26, 2, p. 89-100 12 p.

Research output: Contribution to journalArticle

Cholecystokinin Receptors
Fluorescence
Potassium Iodide
Cholecystokinin
Anisotropy
19 Citations (Scopus)
Cholecystokinin A Receptor
Cholecystokinin B Receptor
Cholecystokinin
Chemical activation
Conformations