Biochemistry and Molecular Biology

Research Output

2009

Lack of muc1-regulated β-catenin stability results in aberrant expansion of cd11b +gr1 + Myeloid-derived suppressor cells from the bone marrow

Poh, T. W., Bradley, J. M., Mukherjee, P. & Gendler, S. J., Apr 15 2009, In : Cancer research. 69, 8, p. 3554-3562 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor

Harikumar, K. G., Simms, J., Christopoulos, G., Sexton, P. M. & Miller, L. J., Dec 15 2009, In : Biochemistry. 48, 49, p. 11773-11785 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Molecular basis of metastasis [8]

Lee, J. J. & Lotze, M. T., Apr 16 2009, In : New England Journal of Medicine. 360, 16, 1 p.

Research output: Contribution to journalLetter

9 Scopus citations

Mouse eosinophils possess potent antibacterial properties in vivo

Linch, S. N., Kelly, A. M., Danielson, E. T., Pero, R., Lee, J. J. & Gold, J. A., Nov 2009, In : Infection and Immunity. 77, 11, p. 4976-4982 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Pathology in practice

Gades, N. M. & Marier, R. J., Jun 15 2009, In : Journal of the American Veterinary Medical Association. 234, 12, p. 1535-1537 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Predicting protein-protein binding sites in membrane proteins

Bordner, A. J., Sep 24 2009, In : BMC bioinformatics. 10, p. 312 1 p., 312.

Research output: Contribution to journalArticle

22 Scopus citations

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and Type 2 cholecystokinin receptors

Akgün, E., Körner, M., Gao, F., Harikumar, K. G., Waser, B., Reubi, J. C., Portoghese, P. S. & Miller, L. J., Apr 9 2009, In : Journal of Medicinal Chemistry. 52, 7, p. 2138-2147 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene

Jaskelioff, M., Song, W., Xia, J., Liu, C., Kramer, J., Koido, S., Gendler, S. J., Calderwood, S. K. & Gong, J., Dec 1 2009, In : Oncogene. 28, 48, p. 4225-4236 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

The Pyk2 FERM domain as a target to inhibit glioma migration

Loftus, J. C., Yang, Z., Tran, N. L., Kloss, J., Viso, C., Berens, M. E. & Lipinski, C. A., Jun 2009, In : Molecular cancer therapeutics. 8, 6, p. 1505-1514 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function

Fortin, S. P., Ennis, M. J., Savitch, B. A., Carpentieri, D., McDonough, W. S., Winkles, J. A., Loftus, J. C., Kingsley, C., Hostetter, G. & Tran, N. L., Nov 2009, In : Molecular Cancer Research. 7, 11, p. 1871-1881 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Use of fluorescence indicators in receptor ligands.

Harikumar, K. G. & Miller, L. J., 2009, In : Methods in molecular biology (Clifton, N.J.). 552, p. 279-291 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2010

Airway eosinophilia in remission and progression of asthma: Accumulation with a fast decline of FEV1

Broekema, M., Volbeda, F., Timens, W., Dijkstra, A., Lee, N. A., Lee, J. J., Lodewijk, M. E., Postma, D. S., Hylkema, M. N. & Ten Hacken, N. H. T., Sep 1 2010, In : Respiratory Medicine. 104, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Altered eosinophil profile in mice with ST6Gal-1 deficiency: An additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation

Nasirikenari, M., Chandrasekaran, E. V., Matta, K. L., Segal, B. H., Bogner, P. N., Lugade, A. A., Thanavala, Y., Lee, J. J. & Lau, J. T. Y., Mar 2010, In : Journal of Leukocyte Biology. 87, 3, p. 457-466 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model

Pinkhasov, J., Alvarez, M. L., Pathangey, L. B., Tinder, T. L., Mason, H. S., Walmsley, A. M., Gendler, S. J. & Mukherjee, P., Dec 2010, In : Cancer Immunology, Immunotherapy. 59, 12, p. 1801-1811 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation

Pioszak, A. A., Harikumar, K. G., Parker, N. R., Miller, L. J. & Xu, H. E., Apr 16 2010, In : Journal of Biological Chemistry. 285, 16, p. 12435-12444 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints

Dong, M., Pinon, D. I., Bordner, A. J. & Miller, L. J., Oct 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6040-6044 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Eosinophils in health and disease: The LIAR hypothesis

Lee, J. J., Jacobsen, E. A., McGarry, M. P., Schleimer, R. P. & Lee, N. A., Apr 2010, In : Clinical and Experimental Allergy. 40, 4, p. 563-575 13 p.

Research output: Contribution to journalComment/debate

166 Scopus citations

Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization

Harikumar, K. G., Ball, A. M., Sexton, P. M. & Miller, L. J., Sep 2010, In : Regulatory Peptides. 164, 2-3, p. 113-119 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-a

Conover, C. A., Bale, L. K., Mader, J. R., Mason, M. A., Keenan, K. P. & Marler, R. J., Jun 2010, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 65 A, 6, p. 590-599 10 p.

Research output: Contribution to journalArticle

60 Scopus citations

Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization

Harikumar, K. G., Akgün, E., Portoghese, P. S. & Miller, L. J., Apr 8 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2836-2842 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Molecular mechanism of ATP-dependent solute transport by multidrug resistance-associated protein 1.

Chang, X. B., 2010, In : Methods in molecular biology (Clifton, N.J.). 596, p. 223-249 27 p.

Research output: Contribution to journalReview article

25 Scopus citations

MultiRTA: A simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes

Bordner, A. J. & Mittelmann, H. D., Sep 24 2010, In : BMC bioinformatics. 11, 482.

Research output: Contribution to journalArticle

31 Scopus citations

Murine lung eosinophil activation and chemokine production in allergic airway inflammation

Rose, C. E., Lannigan, J. A., Kim, P., Lee, J. J., Fu, S. M. & Sung, S. S. J., 2010, In : Cellular and Molecular Immunology. 7, 5, p. 361-374 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Novel model of TH2-polarized chronic ileitis: The SAMPl mouse

McNamee, E. N., Wermers, J. D., Masterson, J. C., Collins, C. B., Matthew, D. P., Lebsack, B. A., Fillon, S., Robinson, Z. D., Grenawalt, J., Lee, J. J., Jedlicka, P., Furuta, G. T. & Rivera-Nieves, J., 2010, In : Inflammatory bowel diseases. 16, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Orientation-dependent backbone-only residue pair scoring functions for fixed backbone protein design

Bordner, A. J., Apr 16 2010, In : BMC bioinformatics. 11, 192.

Research output: Contribution to journalArticle

5 Scopus citations

Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model

Bordner, A. J. & Mittelmann, H. D., Jan 20 2010, In : BMC bioinformatics. 11, 41.

Research output: Contribution to journalArticle

23 Scopus citations

Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides

Dong, M., Narang, P., Pinon, D. I., Bordner, A. J. & Miller, L. J., Jun 2010, In : Peptides. 31, 6, p. 1094-1098 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo (The Journal of Immunology (2008) 181, (3137-3147))

Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J., Felts, S. J. & Pease, L. R., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6556 1 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled Receptors

Harikumar, K. G., Dong, M. & Miller, L. J., Jul 15 2010, GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions. John Wiley and Sons, p. 138-164 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2

Meurice, N., Wang, L., Lipinski, C. A., Yang, Z., Hulme, C. & Loftus, J. C., 2010, In : Journal of Medicinal Chemistry. 53, 2, p. 669-677 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Targeting Pyk2 for therapeutic intervention

Lipinski, C. A. & Loftus, J. C., Jan 2010, In : Expert opinion on therapeutic targets. 14, 1, p. 95-108 14 p.

Research output: Contribution to journalReview article

72 Scopus citations

Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes

Bordner, A. J., 2010, In : PloS one. 5, 12, e14383.

Research output: Contribution to journalArticle

17 Scopus citations

TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling

Paulino, V. M., Yang, Z., Kloss, J., Ennis, M. J., Armstrong, B. A., Loftus, J. C. & Tran, N. L., Nov 2010, In : Molecular Cancer Research. 8, 11, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2011

CCR3 blockade attenuates eosinophilic ileitis and associated remodeling

Masterson, J. C., McNamee, E. N., Jedlicka, P., Fillon, S., Ruybal, J., Hosford, L., Rivera-Nieves, J., Lee, J. J. & Furuta, G. T., Nov 2011, In : American Journal of Pathology. 179, 5, p. 2302-2314 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

Zhu, Y. X., Braggio, E., Shi, C. X., Bruins, L. A., Schmidt, J. E., Van Wier, S., Chang, X. B., Bjorklund, C. C., Fonseca, R., Bergsagel, P. L., Orlowski, R. Z. & Stewart, A. K., Nov 3 2011, In : Blood. 118, 18, p. 4771-4779 9 p.

Research output: Contribution to journalArticle

378 Scopus citations

Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal

Kinlough, C. L., Poland, P. A., Gendler, S. J., Mattila, P. E., Mo, D., Weisz, O. A. & Hughey, R. P., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39072-39081 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Efficient molecular mechanics simulations of the folding, orientation, and assembly of peptides in lipid bilayers using an implicit atomic solvation model

Bordner, A. J., Zorman, B. & Abagyan, R., Oct 2011, In : Journal of Computer-Aided Molecular Design. 25, 10, p. 895-911 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Eosinophilic oesophagitis in adults - A rising epidemic

Pasha, S. F., Crowell, M. D., Alexander, J. A., Harris, L. A., Achem, S. R., Farrugia, G., Lee, J. J., Thompson, D. M., Jung, K. W., Kita, H., Ravi, K., Namasivayam, V., Kim, H. J., Fleischer, D. E., Sharma, V. K. & Romero, Y., Feb 2011, In : European Gastroenterology and Hepatology Review. 7, 1, p. 14-20 7 p.

Research output: Contribution to journalReview article

1 Scopus citations

Eosinophils

Lee, N. A., Dahl, M. V., Jacobsen, E. A. & Ochkur, S. I., Jul 27 2011, Inflammation and Allergy Drug Design. Wiley-Blackwell, p. 107-121 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension

Weng, M., Baron, D. M., Bloch, K. D., Luster, A. D., Lee, J. J. & Medoff, B. D., Dec 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 6, p. L927-L936

Research output: Contribution to journalArticle

21 Scopus citations

Eosinophils are required for the maintenance of plasma cells in the bone marrow

Chu, V. T., Fröhlich, A., Steinhauser, G., Scheel, T., Roch, T., Fillatreau, S., Lee, J. J., Löhning, M. & Berek, C., Feb 1 2011, In : Nature immunology. 12, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

310 Scopus citations

Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, E. L., Simpson, E. L., Fredrikson, L. J., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., 2011, In : PloS one. 6, 7, e22029.

Research output: Contribution to journalArticle

48 Scopus citations

Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation

Jacobsen, E. A., Zellner, K. R., Colbert, D., Lee, N. A. & Lee, J. J., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 6059-6068 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Fluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor

Harikumar, K. G., Cawston, E. E. & Miller, L. J., Aug 1 2011, In : Assay and Drug Development Technologies. 9, 4, p. 394-402 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor

Yang, R., Hou, Y. X., Campbell, C. A., Palaniyandi, K., Zhao, Q., Bordner, A. J. & Chang, X. B., Jul 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 7, p. 1790-1796 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury

Willetts, L., Parker, K., Wesselius, L. J., Protheroe, C. A., Jaben, E., Graziano, P., Moqbel, R., Leslie, K. O., Lee, N. A. & Lee, J. J., Aug 26 2011, In : Respiratory Research. 12, 116.

Research output: Contribution to journalArticle

19 Scopus citations

Importance and regulation of the colonic mucus barrier in a mouse model of colitis

Petersson, J., Schreiber, O., Hansson, G. C., Gendler, S. J., Velcich, A., Lundberg, J. O., Roos, S., Holm, L. & Phillipson, M., Feb 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 2, p. G327-G333

Research output: Contribution to journalArticle

184 Scopus citations

Importance of each residue within secretin for receptor binding and biological activity

Dong, M., Le, A., Te, J. A., Pinon, D. I., Bordner, A. J. & Miller, L. J., Apr 12 2011, In : Biochemistry. 50, 14, p. 2983-2993 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
6 Scopus citations

Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist

Dong, M., Te, J. A., Xu, X., Wang, J., Pinon, D. I., Storjohann, L., Bordner, A. J. & Miller, L. J., Sep 27 2011, In : Biochemistry. 50, 38, p. 8181-8192 12 p.

Research output: Contribution to journalArticle

16 Scopus citations