• 41833 Citations
  • 104 Scopus h-Index
1980 …2020

Research output per year

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Article
2007

Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men

Basu, R., Dalla Man, C., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C. & Rizza, R. A., Aug 2007, In : Diabetes care. 30, 8, p. 1972-1978 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Effect of blockade of TNF-α and interleukin-1 action on bone resorption in early postmenopausal women

Charatcharoenwitthaya, N., Khosla, S., Atkinson, E. J., McCready, L. K. & Riggs, B. L., May 2007, In : Journal of Bone and Mineral Research. 22, 5, p. 724-729 6 p.

Research output: Contribution to journalArticle

157 Scopus citations

Effects of loss of classical estrogen response element signaling on bone in male mice

Syed, F. A., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L. & Khosla, S., Apr 2007, In : Endocrinology. 148, 4, p. 1902-1910 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Effects of testosterone and estradiol on cutaneous vasodilation during local warming in older men

Sokolnicki, L. A., Khosla, S. & Charkoudian, N., Nov 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 293, 5, p. E1426-E1429

Research output: Contribution to journalArticle

10 Scopus citations

High serum IGFBP-2 is predictive of increased bone turnover in aging men and women

Amin, S., Riggs, B. L., Melton, L. J., Achenbach, S. J., Atkinson, E. J. & Khosla, S., Jun 2007, In : Journal of Bone and Mineral Research. 22, 6, p. 799-807 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Osteopenia

Khosla, S. & Melton, L. J., May 31 2007, In : New England Journal of Medicine. 356, 22, p. 2293-2300 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Structural determinants of vertebral fracture risk

Mellon, L. J., Riggs, B. L., Keaveny, T. M., Achenbach, S. J., Hoffmann, P. F., Camp, J. J., Rouleau, P. A., Bouxsein, M. L., Amin, S., Atkinson, E. J., Robb, R. A. & Khosla, S., Dec 1 2007, In : Journal of Bone and Mineral Research. 22, 12, p. 1885-1892 8 p.

Research output: Contribution to journalArticle

147 Scopus citations

Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women

Basu, R., Man, C. D., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C. & Rizza, R. A., Mar 2007, In : Diabetes. 56, 3, p. 753-766 14 p.

Research output: Contribution to journalArticle

44 Scopus citations
2006

{A figure is presented} Long-term fracture risk among women with proven endometriosis

Melton, L. J., Leibson, C. L., Good, A. E., Achenbach, S. J., Oberg, A. L. & Khosla, S., Dec 1 2006, In : Fertility and Sterility. 86, 6, p. 1576-1583 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Age- and sex-specific differences in the factor of risk for vertebral fracture: A population-based study using QCT

Bouxsein, M. L., Melton, L. J., Riggs, B. L., Muller, J., Atkinson, E. J., Oberg, A. L., Robb, R. A., Camp, J. J., Rouleau, P. A., McCollough, C. H. & Khosla, S., Sep 2006, In : Journal of Bone and Mineral Research. 21, 9, p. 1475-1482 8 p.

Research output: Contribution to journalArticle

118 Scopus citations

Bone turnover across the menopause transition: Correlations with inhibins and follicle-stimulating hormone

Perrien, D. S., Achenbach, S. J., Bledsoe, S. E., Walser, B., Suva, L. J., Khosla, S. & Gaddy, D., May 1 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 5, p. 1848-1854 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

Circulating cells with osteogenic potential

Khosla, S. & Eghbali-Fatourechi, G. Z., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 489-497 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Clinical practice guideline: Androgen therapy in women: An Endocrine Society clinical practice guideline

Wierman, M. E., Basson, R., Davis, S. R., Khosla, S., Miller, K. K., Rosner, W. & Santoro, N., Oct 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 10, p. 3697-3710 14 p.

Research output: Contribution to journalArticle

243 Scopus citations

DHEA in elderly women and DHEA or testosterone in elderly men

Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., Cobelli, C., Toffolo, G., Man, C. D., Tindall, D. J., Melton, L. J., Smith, G. E., Khosla, S. & Jensen, M. D., Oct 19 2006, In : New England Journal of Medicine. 355, 16, p. 1647-1659 13 p.

Research output: Contribution to journalArticle

431 Scopus citations

Does reduced skeletal loading account for age-related bone loss?

Melton, L. J., Riggs, B. L., Achenbach, S. J., Amin, S., Camp, J. J., Rouleau, P. A., Robb, R. A., Oberg, A. L. & Khosla, S., Dec 2006, In : Journal of Bone and Mineral Research. 21, 12, p. 1847-1855 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Effects of sex and age on bone microstructure at the ultradistal radius: A population-based noninvasive in vivo assessment

Khosla, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., McDaniel, L. J., Holets, M., Peterson, J. M. & Melton, L. J., Jan 2006, In : Journal of Bone and Mineral Research. 21, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

401 Scopus citations

Estrogen receptor beta: the antimechanostat?

Khosla, S., Modder, U. I., Moedder, U. I. & Syed, F. A., Feb 1 2006, In : Bone. 38, 2

Research output: Contribution to journalArticle

1 Scopus citations

Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: Roles of AF1 and enhancer elements

Monroe, D. G., Secreto, F. J., Hawse, J. R., Subramaniam, M., Khosla, S. & Spelsberg, T. C., Sep 29 2006, In : Journal of Biological Chemistry. 281, 39, p. 28596-28604 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men

Khosla, S., Melton, L. J., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., Mar 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 3, p. 885-891 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993-2001: An update on the changing epidemiology of the disease

Wermers, R. A., Khosla, S., Atkinson, E. J., Achenbach, S. J., Oberg, A. L., Grant, C. S. & Melton, L. J., Jan 1 2006, In : Journal of Bone and Mineral Research. 21, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

261 Scopus citations

Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Oberg, A. L., Rouleau, P. A., McCollough, C. H., Khosla, S. & Bouxsein, M. L., Feb 2006, In : Journal of Bone and Mineral Research. 21, 2, p. 315-323 9 p.

Research output: Contribution to journalArticle

85 Scopus citations
2005
6 Scopus citations

Bone marrow stromal cells express two distinct splice variants of ER-α that are regulated by estrogen

Sanyal, A., Riggs, B. L., Spelsberg, T. C. & Khosla, S., Jan 1 2005, In : Journal of cellular biochemistry. 94, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Circulating osteoblast-lineage cells in humans

Eghbali-Fatourechi, G. Z., Lamsam, J., Fraser, D., Nagel, D., Riggs, B. L. & Khosla, S., May 12 2005, In : New England Journal of Medicine. 352, 19, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

298 Scopus citations
88 Scopus citations

Estrogen receptor α and β heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2Os osteosarcoma cells

Monroe, D. G., Secreto, F. J., Subramaniam, M., Getz, B. J., Khosla, S. & Spelsberg, T. C., Jun 1 2005, In : Molecular Endocrinology. 19, 6, p. 1555-1568 14 p.

Research output: Contribution to journalArticle

111 Scopus citations

Osteoporosis assessment by whole body region vs. site-specific DXA

Melton, L. J., Looker, A. C., Shepherd, J. A., O'Connor, M. K., Achenbach, S. J., Riggs, B. L. & Khosla, S., Dec 1 2005, In : Osteoporosis International. 16, 12, p. 1558-1564 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men

Khosla, S., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Oberg, A. L., Rouleau, P. A. & Riggs, B. L., May 2005, In : Journal of Bone and Mineral Research. 20, 5, p. 730-740 11 p.

Research output: Contribution to journalArticle

104 Scopus citations

Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women

Khosla, S., Riggs, B. L., Robb, R. A., Camp, J. J., Achenbach, S. J., Oberg, A. L., Rouleau, P. A. & Melton, L. J., Sep 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 9, p. 5096-5103 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways

Syed, F. A., Mödder, U. I. L., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L. & Khosla, S., Nov 2005, In : Journal of Bone and Mineral Research. 20, 11, p. 1992-2001 10 p.

Research output: Contribution to journalArticle

63 Scopus citations
2004

A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors

Nagel, D. E., Khosla, S., Sanyal, A., Rosen, D. M., Kumagai, Y. & Riggs, B. L., Dec 1 2004, In : Journal of cellular biochemistry. 93, 6, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

A potentially deleterious role of IGFBP-2 on bone density in aging men and women

Amin, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Melton, L. J. & Khosla, S., Jul 1 2004, In : Journal of Bone and Mineral Research. 19, 7, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Dose-response of estrogen on bone versus the uterus in ovariectomized mice

Mödder, U. I. L., Riggs, B. L., Spelsberg, T. C., Fraser, D. G., Atkinson, E. J., Arnold, R. & Khosla, S., Oct 1 2004, In : European journal of endocrinology. 151, 4, p. 503-510 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Effects of Loss of Steroid Receptor Coactivator-1 on the Skeletal Response to Estrogen in Mice

Mödder, U. I. L., Sanyal, A., Kearns, A. E., Sibonga, J. D., Nishihara, E., Xu, J., O'Malley, B. W., Ritman, E. L., Riggs, B. L., Spelsberg, T. C. & Khosla, S., Feb 1 2004, In : Endocrinology. 145, 2, p. 913-921 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Fracture risk in monoclonal gammopathy of undetermined significance

Melton, L. J., Rajkumar, S. V., Khosla, S., Achenbach, S. J., Oberg, A. L. & Kyle, R. A., Jan 1 2004, In : Journal of Bone and Mineral Research. 19, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

121 Scopus citations

Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts

Doran, P. M., Turner, R. T., Chen, D., Facteau, S. M., Ludvigson, J. M., Khosla, S., Riggs, B. L. & Russell, S. J., Apr 1 2004, In : Experimental Hematology. 32, 4, p. 351-359 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Osteoporosis in men - Consensus is premature

Seeman, E., Bianchi, G., Adami, S., Kanis, J., Khosla, S. & Orwoll, E., Aug 1 2004, In : Calcified Tissue International. 75, 2, p. 120-122 3 p.

Research output: Contribution to journalArticle

31 Scopus citations

Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Peterson, J. M., Rouleau, P. A., McCollough, C. H., Bouxsein, M. L. & Khosla, S., Dec 2004, In : Journal of Bone and Mineral Research. 19, 12, p. 1945-1954 10 p.

Research output: Contribution to journalArticle

596 Scopus citations

Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men

Khosla, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Mavilia, C., Del Monte, F., Melton, L. J. & Brandi, M. L., Apr 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 4, p. 1808-1816 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Role of hormonal changes in the pathogenesis of osteoporosis in men

Khosla, S., Aug 1 2004, In : Calcified Tissue International. 75, 2, p. 110-113 4 p.

Research output: Contribution to journalArticle

28 Scopus citations
2003

Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells

Shui, C., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Feb 1 2003, In : Journal of Bone and Mineral Research. 18, 2, p. 213-221 9 p.

Research output: Contribution to journalArticle

183 Scopus citations

Effect of estrogen replacement therapy on parathyroid hormone secretion in elderly postmenopausal women

Vincent, A., Riggs, B. L., Atkinson, E. J., Oberg, A. L. & Khosla, S., Mar 2003, In : Menopause. 10, 2, p. 165-171 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERα or ERβ

Monroe, D. G., Getz, B. J., Johnsen, S. A., Riggs, B. L., Khosla, S. & Spelsberg, T. C., Oct 1 2003, In : Journal of cellular biochemistry. 90, 2, p. 315-326 12 p.

Research output: Contribution to journalArticle

122 Scopus citations

Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency

Riggs, B. L., Khosla, S., Atkinson, E. J., Dunstan, C. R. & Melton, L. J., Sep 1 2003, In : Osteoporosis International. 14, 9, p. 728-733 6 p.

Research output: Contribution to journalArticle

61 Scopus citations

Fracture Risk After Bilateral Oophorectomy in Elderly Women

Melton, L. J., Khosla, S., Malkasian, G. D., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., May 1 2003, In : Journal of Bone and Mineral Research. 18, 5, p. 900-905 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Fracture risk following bilateral orchiectomy

Melton, L. J., Alothman, K. I., Khosla, S., Achenbach, S. J., Oberg, A. L. & Zincke, H., May 1 2003, In : Journal of Urology. 169, 5, p. 1747-1750 4 p.

Research output: Contribution to journalArticle

131 Scopus citations

Incidence of Childhood Distal Forearm Fractures over 30 Years: A Population-Based Study

Khosla, S., Melton, L. J., Dekutoski, M. B., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., Sep 17 2003, In : Journal of the American Medical Association. 290, 11, p. 1479-1485 7 p.

Research output: Contribution to journalArticle

316 Scopus citations

Measurement of gene expression following cryogenic μ-CT scanning of human iliac crest biopsies

Maran, A., Khosla, S., Riggs, B. L., Zhang, M., Ritman, E. L. & Turner, R. T., Mar 1 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone

Locklin, R. M., Khosla, S., Turner, R. T. & Riggs, B. L., May 1 2003, In : Journal of cellular biochemistry. 89, 1, p. 180-190 11 p.

Research output: Contribution to journalArticle

167 Scopus citations

Mutual antagonism of estrogen receptors α and β and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines

Monroe, D. G., Johnsen, S. A., Subramaniam, M., Getz, B. J., Khosla, S., Riggs, B. L. & Spelsberg, T. C., Mar 1 2003, In : Journal of Endocrinology. 176, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

45 Scopus citations