• 38762 Citations
  • 100 Scopus h-Index
1976 …2021
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Research Output 1980 2019

2005
58 Citations (Scopus)

Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women

Khosla, S., Riggs, B. L., Robb, R. A., Camp, J. J., Achenbach, S. J., Oberg, A. L., Rouleau, P. A. & Melton, L. J., Sep 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 9, p. 5096-5103 8 p.

Research output: Contribution to journalArticle

Bone Density
Bone
Steroids
Minerals
Bone and Bones
59 Citations (Scopus)

Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways

Syed, F. A., Mödder, U. I. L., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L. & Khosla, S., Nov 2005, In : Journal of Bone and Mineral Research. 20, 11, p. 1992-2001 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Response Elements
Ovariectomy
Estrogen Replacement Therapy
228 Citations (Scopus)

The role of the immune system in the pathophysiology of osteoporosis

Clowes, J. A., Riggs, B. L. & Khosla, S., Dec 2005, In : Immunological Reviews. 208, p. 207-227 21 p.

Research output: Contribution to journalArticle

Osteoporosis
Immune System
RANK Ligand
Osteoprotegerin
Bone and Bones
2004
15 Citations (Scopus)

A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors

Nagel, D. E., Khosla, S., Sanyal, A., Rosen, D. M., Kumagai, Y. & Riggs, B. L., 2004, In : Journal of Cellular Biochemistry. 93, 6, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

Anabolic Agents
Osteocalcin
Osteoblasts
Cyclooxygenase 2
Gene expression
60 Citations (Scopus)

A potentially deleterious role of IGFBP-2 on bone density in aging men and women

Amin, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Melton, L. J. & Khosla, S., Jul 2004, In : Journal of Bone and Mineral Research. 19, 7, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Bone Density
Insulin-Like Growth Factor Binding Proteins
Somatomedins
Insulin-Like Growth Factor I
27 Citations (Scopus)

A system for the analysis of whole-bone strength from helical CT images

Camp, J. J., Karwoski, R. A., Stacy, M. C., Atkinson, E. J., Khosla, S., Melton, L. J., Riggs, B. L. & Robb, R. A., 2004, Proceedings of SPIE - The International Society for Optical Engineering. Amini, A. A. & Mandura, A. (eds.). Vol. 5369. p. 74-88 15 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

bones
Bone
osteoporosis
Minerals
minerals
52 Citations (Scopus)

Dose-response of estrogen on bone versus the uterus in ovariectomized mice

Mödder, U. I. L., Riggs, B. L., Spelsberg, T. C., Fraser, D. G., Atkinson, E. J., Arnold, R. & Khosla, S., Oct 2004, In : European Journal of Endocrinology. 151, 4, p. 503-510 8 p.

Research output: Contribution to journalArticle

Uterus
Estrogens
Bone and Bones
Inbred C57BL Mouse
Ovariectomy
57 Citations (Scopus)

Effects of Loss of Steroid Receptor Coactivator-1 on the Skeletal Response to Estrogen in Mice

Mödder, U. I. L., Sanyal, A., Kearns, A. E., Sibonga, J. D., Nishihara, E., Xu, J., O'Malley, B. W., Ritman, E. L., Riggs, B. L., Spelsberg, T. C. & Khosla, S., Feb 2004, In : Endocrinology. 145, 2, p. 913-921 9 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 1
Estrogens
Knockout Mice
Bone and Bones
Nuclear Receptor Coactivators
113 Citations (Scopus)

Fracture risk in monoclonal gammopathy of undetermined significance

Melton, L. J., Rajkumar, S. V., Khosla, S., Achenbach, S. J., Oberg, A. L. & Kyle, R. A., Jan 2004, In : Journal of Bone and Mineral Research. 19, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Incidence
Bone Remodeling
Multiple Myeloma
Cohort Studies
20 Citations (Scopus)

Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts

Doran, P. M., Turner, R. T., Chen, D., Facteau, S. M., Ludvigson, J. M., Khosla, S., Riggs, B. L. & Russell, S. J., Apr 2004, In : Experimental Hematology. 32, 4, p. 351-359 9 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Bone Diseases
Heterografts
Genes
Neoplasms
29 Citations (Scopus)

Osteoporosis in men - Consensus is premature

Seeman, E., Bianchi, G., Adami, S., Kanis, J., Khosla, S. & Orwoll, E., Aug 2004, In : Calcified Tissue International. 75, 2, p. 120-122 3 p.

Research output: Contribution to journalArticle

Bone Development
Bone Fractures
Puberty
Sex Characteristics
Italy
556 Citations (Scopus)

Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Peterson, J. M., Rouleau, P. A., McCollough, C. H., Bouxsein, M. L. & Khosla, S., Dec 2004, In : Journal of Bone and Mineral Research. 19, 12, p. 1945-1954 10 p.

Research output: Contribution to journalArticle

Sex Characteristics
Bone Density
Bone and Bones
Population
Bone Remodeling
9 Citations (Scopus)

Potential Anabolic Effects of Androgens on Bone

Kearns, A. E. & Khosla, S., 2004, In : Mayo Clinic Proceedings. 79, 4 SUPPL.

Research output: Contribution to journalArticle

Anabolic Agents
Androgens
Estrogens
Menopause
Bone and Bones
55 Citations (Scopus)

Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men

Khosla, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Mavilia, C., Del Monte, F., Melton, L. J. & Brandi, M. L., Apr 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 4, p. 1808-1816 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Bone Density
Minerals
Bone
Genotype
28 Citations (Scopus)

Role of hormonal changes in the pathogenesis of osteoporosis in men

Khosla, S., Aug 2004, In : Calcified Tissue International. 75, 2, p. 110-113 4 p.

Research output: Contribution to journalArticle

Osteoporosis
Steroids
Insulin-Like Growth Factor I
Bone and Bones
Bone Resorption

The Role of Androgens and Estrogens in the Male Skeleton

Khosla, S. & Bilezikian, J. P., 2004, Principles of Gender-Specific Medicine. Elsevier Inc., Vol. 2. p. 1021-1032 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Skeleton
Androgens
Estrogens
Steroids
Bone
2003
11 Citations (Scopus)

Androgens, estrogens, and bone turnover in men (multiple letters)

Khosla, S., Riggs, B. L., Leder, B. Z. & Finkelstein, J. S., May 1 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 5, p. 2352-2353 2 p.

Research output: Contribution to journalArticle

Bone Remodeling
Androgens
Bone
Estrogens
172 Citations (Scopus)

Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells

Shui, C., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Feb 1 2003, In : Journal of Bone and Mineral Research. 18, 2, p. 213-221 9 p.

Research output: Contribution to journalArticle

Osteoblasts
Mesenchymal Stromal Cells
Messenger RNA
Core Binding Factor Alpha 1 Subunit
Rodentia
14 Citations (Scopus)

Effect of estrogen replacement therapy on parathyroid hormone secretion in elderly postmenopausal women

Vincent, A., Riggs, B. L., Atkinson, E. J., Oberg, A. L. & Khosla, S., Mar 2003, In : Menopause. 10, 2, p. 165-171 7 p.

Research output: Contribution to journalArticle

Estrogen Replacement Therapy
Parathyroid Hormone
Estrogens
Calcium
Kidney
10 Citations (Scopus)
Selective Estrogen Receptor Modulators
Androgen Receptors
Estrogen Receptors
Estrogens
Ligands
121 Citations (Scopus)

Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERα or ERβ

Monroe, D. G., Getz, B. J., Johnsen, S., Riggs, B. L., Khosla, S. & Spelsberg, T. C., Oct 1 2003, In : Journal of Cellular Biochemistry. 90, 2, p. 315-326 12 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Gene expression
Estrogen Receptors
Protein Isoforms
Genes
60 Citations (Scopus)

Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency

Riggs, B. L., Khosla, S., Atkinson, E. J., Dunstan, C. R. & Melton, L. J., Sep 2003, In : Osteoporosis International. 14, 9, p. 728-733 6 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Bone and Bones
Bone Remodeling
Steroids
89 Citations (Scopus)

Fracture Risk After Bilateral Oophorectomy in Elderly Women

Melton, L. J., Khosla, S., Malkasian, G. D., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., May 1 2003, In : Journal of Bone and Mineral Research. 18, 5, p. 900-905 6 p.

Research output: Contribution to journalArticle

Ovariectomy
Osteoporotic Fractures
Estrogens
Menopause
Ovary
129 Citations (Scopus)

Fracture risk following bilateral orchiectomy

Melton, L. J., Alothman, K. I., Khosla, S., Achenbach, S. J., Oberg, A. L. & Zincke, H., May 1 2003, In : Journal of Urology. 169, 5, p. 1747-1750 4 p.

Research output: Contribution to journalArticle

Orchiectomy
Spontaneous Fractures
Incidence
Osteoporosis
Prostatic Neoplasms
303 Citations (Scopus)

Incidence of Childhood Distal Forearm Fractures over 30 Years: A Population-Based Study

Khosla, S., Melton, L. J., Dekutoski, M. B., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., Sep 17 2003, In : Journal of the American Medical Association. 290, 11, p. 1479-1485 7 p.

Research output: Contribution to journalArticle

Forearm
Confidence Intervals
Incidence
Population
Exercise
3 Citations (Scopus)

Increasing Rates of Forearm Fractures in Children [4] (multiple letters)

Swiontkowski, M. F., Khosla, S., Melton, L. J. & Dekutoski, M. B., Dec 24 2003, In : Journal of the American Medical Association. 290, 24, p. 3193 1 p.

Research output: Contribution to journalArticle

Ulna Fractures
Radius Fractures
Forearm
Incidence
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor II
12 Citations (Scopus)

Measurement of gene expression following cryogenic μ-CT scanning of human iliac crest biopsies

Maran, A., Khosla, S., Riggs, B. L., Zhang, M., Ritman, E. L. & Turner, R. T., Mar 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

Biopsy
Gene Expression
Bone and Bones
Transforming Growth Factors
Bone Matrix
161 Citations (Scopus)

Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone

Locklin, R. M., Khosla, S., Turner, R. T. & Riggs, B. L., May 1 2003, In : Journal of Cellular Biochemistry. 89, 1, p. 180-190 11 p.

Research output: Contribution to journalArticle

RANK Ligand
Parathyroid Hormone
Osteoprotegerin
Bone
Insulin-Like Growth Factor I
44 Citations (Scopus)

Mutual antagonism of estrogen receptors α and β and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines

Monroe, D. G., Johnsen, S., Subramaniam, M., Getz, B. J., Khosla, S., Riggs, B. L. & Spelsberg, T. C., Mar 1 2003, In : Journal of Endocrinology. 176, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

Steroid Receptors
Estrogen Receptors
Protein Isoforms
Estrogens
Cell Line
59 Citations (Scopus)

Parathyroid hormone plus alendronate - A combination that does not add up

Khosla, S., Sep 25 2003, In : New England Journal of Medicine. 349, 13, p. 1277-1279 3 p.

Research output: Contribution to journalArticle

Alendronate
Lumbar Vertebrae
Bone Remodeling
Femur Neck
Combination Drug Therapy
95 Citations (Scopus)

Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors α and β

Rickard, D. J., Monroe, D. G., Ruesink, T. J., Khosla, S., Riggs, B. L. & Spelsberg, T. C., Jun 1 2003, In : Journal of Cellular Biochemistry. 89, 3, p. 633-646 14 p.

Research output: Contribution to journalArticle

Phytoestrogens
Genistein
Estrogen Receptors
Estrogens
Gene expression
39 Citations (Scopus)
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor II
Osteoblasts
Extracellular Matrix
Insulin-Like Growth Factor I
20 Citations (Scopus)

Role of parathyroid hormone in mediating age-related changes in bone resorption in men

Kennel, K. A., Riggs, B. L., Achenbach, S. J., Oberg, A. L. & Khosla, S., Aug 2003, In : Osteoporosis International. 14, 8, p. 631-636 6 p.

Research output: Contribution to journalArticle

Bone Resorption
Parathyroid Hormone
Intravenous Infusions
Urine
Calcium
535 Citations (Scopus)

Role of RANK ligand in mediating increased bone resorption in early postmenopausal women

Eghbali-Fatourechi, G., Khosla, S., Sanyal, A., Boyle, W. J., Lacey, D. L. & Riggs, B. L., Apr 2003, In : Journal of Clinical Investigation. 111, 8, p. 1221-1230 10 p.

Research output: Contribution to journalArticle

RANK Ligand
Bone Resorption
Fluorescein-5-isothiocyanate
Estrogens
Stromal Cells
29 Citations (Scopus)

Surrogates for Fracture Endpoints in Clinical Trials

Khosla, S., Jun 1 2003, In : Journal of Bone and Mineral Research. 18, 6, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

Postmenopause
Postmenopausal Osteoporosis
Bone Fractures
Bone Density
Meta-Analysis
32 Citations (Scopus)

The role of estrogens in men and androgens in women

Khosla, S. & Bilezikian, J. P., Feb 2003, In : Endocrinology and Metabolism Clinics of North America. 32, 1, p. 195-218 24 p.

Research output: Contribution to journalArticle

Androgens
Bone
Estrogens
Steroids
Osteogenesis
2002
5 Citations (Scopus)

Bisphosphonates and the upper gastrointestinal tract: Skeletal gain without visceral pain?

Tremaine, W. J. & Khosla, S., Oct 1 2002, In : Mayo Clinic Proceedings. 77, 10, p. 1029-1030 2 p.

Research output: Contribution to journalArticle

Visceral Pain
Upper Gastrointestinal Tract
Diphosphonates
246 Citations (Scopus)

Clinical review 144: Estrogen and the male skeleton

Khosla, S., Joseph Melton, L. & Lawrence Riggs, B., 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 4, p. 1443-1450 8 p.

Research output: Contribution to journalArticle

Skeleton
Bone
Estrogens
Aromatase
Bone Remodeling
162 Citations (Scopus)

Correlates of osteoprotegerin levels in women and men

Khosla, S., Arrighi, H. M., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Dunstan, C. & Riggs, B. L., 2002, In : Osteoporosis International. 13, 5, p. 394-399 6 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Bone Remodeling
Bone Density
Bone and Bones
Serum
53 Citations (Scopus)

Editorial: Leptin - Central or peripheral to the regulation of bone metabolism?

Khosla, S., Nov 1 2002, In : Endocrinology. 143, 11, p. 4161-4164 4 p.

Research output: Contribution to journalArticle

Food Deprivation
Physiologic Calcification
Bone Development
Leptin
Body Composition
150 Citations (Scopus)

Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men

Khosla, S., Atkinson, E. J., Dunstan, C. R. & O'Fallon, W. M., 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 4, p. 1550-1554 5 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Testosterone
Estrogens
Cytokines
Bone Resorption
39 Citations (Scopus)

Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts

Rickard, D. J., Waters, K. M., Ruesink, T. J., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Riggs, B. L. & Spelsberg, T. C., 2002, In : Journal of Bone and Mineral Research. 17, 4, p. 580-592 13 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Osteoblasts
Estrogen Receptors
Protein Isoforms
Estrogens
68 Citations (Scopus)

Fracture risk in primary hyperparathyroidism

Khosla, S. & Melton, L. J., Nov 1 2002, In : Journal of Bone and Mineral Research. 17, SUPPL. 2

Research output: Contribution to journalArticle

Primary Hyperparathyroidism
Hip Fractures
Forearm
Parathyroid Hormone
Population
17 Citations (Scopus)

Oestrogen, bones and men: When testosterone just isn't enough

Khosla, S., 2002, In : Clinical Endocrinology. 56, 3, p. 291-293 3 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone Resorption
Estrogen Receptors
Testosterone
Estrogens
50 Citations (Scopus)

Osteopenia in adults with a history of juvenile rheumatoid arthritis. A population based study

French, A. R., Mason, T., Nelson, A. M., Crowson, C., O'Fallon, W. M., Khosla, S. & Gabriel, S. E., 2002, In : Journal of Rheumatology. 29, 5, p. 1065-1070 6 p.

Research output: Contribution to journalArticle

Juvenile Arthritis
Metabolic Bone Diseases
Bone Density
Population
Spine
59 Citations (Scopus)

Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells

Hofbauer, L. C., Hicok, K. C., Chen, D. & Khosla, S., Aug 2002, In : European Journal of Endocrinology. 147, 2, p. 269-273 5 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Androgens
Dihydrotestosterone
Androgen Receptors
Messenger RNA
162 Citations (Scopus)

Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women

Heshmati, H. M., Khosla, S., Robins, S. P., O'Fallon, M. W., Melton, L. J. & Riggs, L., 2002, In : Journal of Bone and Mineral Research. 17, 1, p. 172-178 7 p.

Research output: Contribution to journalArticle

letrozole
Bone Remodeling
Bone Resorption
Estrogens
Serum
33 Citations (Scopus)

Secondary osteoporosis and the risk of distal forearm fractures in men and women

Melton, L. J., Achenbach, S. J., O'fallon, W. M. & Khosla, S., 2002, In : Bone. 31, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

Forearm
Osteoporosis
Odds Ratio
Confidence Intervals
Osteoporotic Fractures
1224 Citations (Scopus)

Sex steroids and the construction and conservation of the adult skeleton

Riggs, B. L., Khosla, S. & Melton, L. J., Jan 1 2002, In : Endocrine Reviews. 23, 3, p. 279-302 24 p.

Research output: Contribution to journalReview article

Skeleton
Steroids
Bone and Bones
Osteoporosis
Osteoblasts