• 40955 Citations
  • 103 Scopus h-Index
1980 …2020

Research output per year

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Research Output

2006

Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: Roles of AF1 and enhancer elements

Monroe, D. G., Secreto, F. J., Hawse, J. R., Subramaniam, M., Khosla, S. & Spelsberg, T. C., Sep 29 2006, In : Journal of Biological Chemistry. 281, 39, p. 28596-28604 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men

Khosla, S., Melton, L. J., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., Mar 1 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 3, p. 885-891 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993-2001: An update on the changing epidemiology of the disease

Wermers, R. A., Khosla, S., Atkinson, E. J., Achenbach, S. J., Oberg, A. L., Grant, C. S. & Melton, L. J., Jan 1 2006, In : Journal of Bone and Mineral Research. 21, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

257 Scopus citations

Letter to the editor [2]

Khosla, S., Moedder, U. I. & Syed, F. A., Feb 1 2006, In : Bone. 38, 2, 1 p.

Research output: Contribution to journalLetter

2 Scopus citations

Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Oberg, A. L., Rouleau, P. A., McCollough, C. H., Khosla, S. & Bouxsein, M. L., Feb 1 2006, In : Journal of Bone and Mineral Research. 21, 2, p. 315-323 9 p.

Research output: Contribution to journalArticle

83 Scopus citations

Sex Steroid Effects on Bone Metabolism

Monroe, D. G., Spelsberg, T. C. & Khosla, S., Dec 1 2006, Dynamics of Bone and Cartilage Metabolism. Elsevier Inc., p. 327-343 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Systemic assessments utilizing saliva: Part 2 - Osteoporosis and use of saliva to measure bone turnover

Koka, S., Forde, M. D. & Khosla, S., Jan 1 2006, In : International Journal of Prosthodontics. 19, 1, p. 53-60 8 p.

Research output: Contribution to journalReview article

16 Scopus citations

The classical estrogen receptor transcriptional pathway: Implications in human osteoblasts

Monroe, D. G., Secreto, F. J., Khosla, S. & Spelsberg, T. C., May 31 2006, In : Clinical Reviews in Bone and Mineral Metabolism. 4, 2, p. 129-140 12 p.

Research output: Contribution to journalReview article

1 Scopus citations
2005
6 Scopus citations

Bone marrow stromal cells express two distinct splice variants of ER-α that are regulated by estrogen

Sanyal, A., Riggs, B. L., Spelsberg, T. C. & Khosla, S., Jan 1 2005, In : Journal of cellular biochemistry. 94, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Circulating osteoblast-lineage cells [4] (multiple letters)

Sata, M., Tanaka, K., Nagai, R., Eghbali-Fatourechi, G. Z. & Khosla, S., Aug 18 2005, In : New England Journal of Medicine. 353, 7, p. 737-738 2 p.

Research output: Contribution to journalLetter

18 Scopus citations

Circulating osteoblast-lineage cells in humans

Eghbali-Fatourechi, G. Z., Lamsam, J., Fraser, D., Nagel, D., Riggs, B. L. & Khosla, S., May 12 2005, In : New England Journal of Medicine. 352, 19, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

292 Scopus citations
88 Scopus citations

Estrogen receptor α and β heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2Os osteosarcoma cells

Monroe, D. G., Secreto, F. J., Subramaniam, M., Getz, B. J., Khosla, S. & Spelsberg, T. C., Jun 1 2005, In : Molecular Endocrinology. 19, 6, p. 1555-1568 14 p.

Research output: Contribution to journalArticle

110 Scopus citations

Evaluation of a prediction model for long-term fracture risk

Melton, L. J., Atkinson, E. J., Khosla, S., Oberg, A. L. & Lawrence Riggs, B., Apr 1 2005, In : Journal of Bone and Mineral Research. 20, 4, p. 551-556 6 p.

Research output: Contribution to journalReview article

25 Scopus citations

Magic bullets to kill nasty osteoclasts

Khosla, S., Aug 1 2005, In : Endocrinology. 146, 8, p. 3233-3234 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations

Mechanisms of sex steroid effects on bone

Syed, F. & Khosla, S., Mar 18 2005, In : Biochemical and Biophysical Research Communications. 328, 3, p. 688-696 9 p.

Research output: Contribution to journalReview article

276 Scopus citations

Osteoporosis assessment by whole body region vs. site-specific DXA

Melton, L. J., Looker, A. C., Shepherd, J. A., O'Connor, M. K., Achenbach, S. J., Riggs, B. L. & Khosla, S., Dec 1 2005, In : Osteoporosis International. 16, 12, p. 1558-1564 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Pathophysiology of age-related bone loss and osteoporosis

Khosla, S. & Riggs, B. L., Dec 1 2005, In : Endocrinology and Metabolism Clinics of North America. 34, 4, p. 1015-1030 16 p.

Research output: Contribution to journalReview article

189 Scopus citations

Potential role of pancreatic and enteric hormones in regulating bone turnover

Clowes, J. A., Khosla, S. & Eastell, R., Sep 1 2005, In : Journal of Bone and Mineral Research. 20, 9, p. 1497-1506 10 p.

Research output: Contribution to journalReview article

69 Scopus citations

Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men

Khosla, S., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Oberg, A. L., Rouleau, P. A. & Riggs, B. L., May 1 2005, In : Journal of Bone and Mineral Research. 20, 5, p. 730-740 11 p.

Research output: Contribution to journalArticle

103 Scopus citations

Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women

Khosla, S., Riggs, B. L., Robb, R. A., Camp, J. J., Achenbach, S. J., Oberg, A. L., Rouleau, P. A. & Melton, L. J., Sep 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 9, p. 5096-5103 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways

Syed, F. A., Mödder, U. I. L., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L. & Khosla, S., Nov 1 2005, In : Journal of Bone and Mineral Research. 20, 11, p. 1992-2001 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

The role of the immune system in the pathophysiology of osteoporosis

Clowes, J. A., Riggs, B. L. & Khosla, S., Dec 1 2005, In : Immunological Reviews. 208, p. 207-227 21 p.

Research output: Contribution to journalReview article

238 Scopus citations
2004

A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors

Nagel, D. E., Khosla, S., Sanyal, A., Rosen, D. M., Kumagai, Y. & Riggs, B. L., Dec 1 2004, In : Journal of cellular biochemistry. 93, 6, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

A potentially deleterious role of IGFBP-2 on bone density in aging men and women

Amin, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Melton, L. J. & Khosla, S., Jul 1 2004, In : Journal of Bone and Mineral Research. 19, 7, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

A system for the analysis of whole-bone strength from helical CT images

Camp, J. J., Karwoski, R. A., Stacy, M. C., Atkinson, E. J., Khosla, S., Melton, L. J., Riggs, B. L. & Robb, R. A., Jul 5 2004, In : Proceedings of SPIE - The International Society for Optical Engineering. 5369, p. 74-88 15 p.

Research output: Contribution to journalConference article

27 Scopus citations

Dose-response of estrogen on bone versus the uterus in ovariectomized mice

Mödder, U. I. L., Riggs, B. L., Spelsberg, T. C., Fraser, D. G., Atkinson, E. J., Arnold, R. & Khosla, S., Oct 1 2004, In : European journal of endocrinology. 151, 4, p. 503-510 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Effects of Loss of Steroid Receptor Coactivator-1 on the Skeletal Response to Estrogen in Mice

Mödder, U. I. L., Sanyal, A., Kearns, A. E., Sibonga, J. D., Nishihara, E., Xu, J., O'Malley, B. W., Ritman, E. L., Riggs, B. L., Spelsberg, T. C. & Khosla, S., Feb 1 2004, In : Endocrinology. 145, 2, p. 913-921 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Fracture risk in monoclonal gammopathy of undetermined significance

Melton, L. J., Rajkumar, S. V., Khosla, S., Achenbach, S. J., Oberg, A. L. & Kyle, R. A., Jan 1 2004, In : Journal of Bone and Mineral Research. 19, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

120 Scopus citations

Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts

Doran, P. M., Turner, R. T., Chen, D., Facteau, S. M., Ludvigson, J. M., Khosla, S., Riggs, B. L. & Russell, S. J., Apr 1 2004, In : Experimental Hematology. 32, 4, p. 351-359 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Osteoporosis in men - Consensus is premature

Seeman, E., Bianchi, G., Adami, S., Kanis, J., Khosla, S. & Orwoll, E., Aug 1 2004, In : Calcified Tissue International. 75, 2, p. 120-122 3 p.

Research output: Contribution to journalArticle

31 Scopus citations

Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Peterson, J. M., Rouleau, P. A., McCollough, C. H., Bouxsein, M. L. & Khosla, S., Dec 1 2004, In : Journal of Bone and Mineral Research. 19, 12, p. 1945-1954 10 p.

Research output: Contribution to journalArticle

588 Scopus citations

Potential Anabolic Effects of Androgens on Bone

Kearns, A. E. & Khosla, S., Apr 2004, In : Mayo Clinic proceedings. 79, 4 SUPPL., p. S14-S18

Research output: Contribution to journalReview article

9 Scopus citations

Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men

Khosla, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Mavilia, C., Del Monte, F., Melton, L. J. & Brandi, M. L., Apr 1 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 4, p. 1808-1816 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Role of hormonal changes in the pathogenesis of osteoporosis in men

Khosla, S., Aug 1 2004, In : Calcified Tissue International. 75, 2, p. 110-113 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

The Role of Androgens and Estrogens in the Male Skeleton

Khosla, S. & Bilezikian, J. P., Dec 1 2004, Principles of Gender-Specific Medicine. Elsevier Inc., Vol. 2. p. 1021-1032 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2003

Androgens, estrogens, and bone turnover in men (multiple letters)

Khosla, S., Riggs, B. L., Leder, B. Z. & Finkelstein, J. S., May 1 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 5, p. 2352-2353 2 p.

Research output: Contribution to journalLetter

11 Scopus citations

Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells

Shui, C., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Feb 1 2003, In : Journal of Bone and Mineral Research. 18, 2, p. 213-221 9 p.

Research output: Contribution to journalArticle

180 Scopus citations

Effect of estrogen replacement therapy on parathyroid hormone secretion in elderly postmenopausal women

Vincent, A., Riggs, B. L., Atkinson, E. J., Oberg, A. L. & Khosla, S., Mar 1 2003, In : Menopause. 10, 2, p. 165-171 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
10 Scopus citations

Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERα or ERβ

Monroe, D. G., Getz, B. J., Johnsen, S. A., Riggs, B. L., Khosla, S. & Spelsberg, T. C., Oct 1 2003, In : Journal of cellular biochemistry. 90, 2, p. 315-326 12 p.

Research output: Contribution to journalArticle

122 Scopus citations

Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency

Riggs, B. L., Khosla, S., Atkinson, E. J., Dunstan, C. R. & Melton, L. J., Sep 1 2003, In : Osteoporosis International. 14, 9, p. 728-733 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

Fracture Risk After Bilateral Oophorectomy in Elderly Women

Melton, L. J., Khosla, S., Malkasian, G. D., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., May 1 2003, In : Journal of Bone and Mineral Research. 18, 5, p. 900-905 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Fracture risk following bilateral orchiectomy

Melton, L. J., Alothman, K. I., Khosla, S., Achenbach, S. J., Oberg, A. L. & Zincke, H., May 1 2003, In : Journal of Urology. 169, 5, p. 1747-1750 4 p.

Research output: Contribution to journalArticle

130 Scopus citations

Incidence of Childhood Distal Forearm Fractures over 30 Years: A Population-Based Study

Khosla, S., Melton, L. J., Dekutoski, M. B., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., Sep 17 2003, In : Journal of the American Medical Association. 290, 11, p. 1479-1485 7 p.

Research output: Contribution to journalArticle

312 Scopus citations

Increasing Rates of Forearm Fractures in Children [4] (multiple letters)

Swiontkowski, M. F., Khosla, S., Melton, L. J. & Dekutoski, M. B., Dec 24 2003, In : Journal of the American Medical Association. 290, 24, 1 p.

Research output: Contribution to journalLetter

3 Scopus citations

Measurement of gene expression following cryogenic μ-CT scanning of human iliac crest biopsies

Maran, A., Khosla, S., Riggs, B. L., Zhang, M., Ritman, E. L. & Turner, R. T., Mar 1 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone

Locklin, R. M., Khosla, S., Turner, R. T. & Riggs, B. L., May 1 2003, In : Journal of cellular biochemistry. 89, 1, p. 180-190 11 p.

Research output: Contribution to journalArticle

165 Scopus citations