• 38586 Citations
  • 100 Scopus h-Index
1976 …2021
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1980 2019

2019
Osteoporotic Fractures
National Institutes of Health (U.S.)
Osteoporosis
Drug Therapy
Research
4 Citations (Scopus)

Cellular senescence in bone

Farr, J. & Khosla, S., Apr 1 2019, In : Bone. 121, p. 121-133 13 p.

Research output: Contribution to journalArticle

Cell Aging
Bone and Bones
Osteoporosis
Phenotype
Chronic Disease
2 Citations (Scopus)

Circulating Osteogenic Progenitor Cells in Mild, Moderate, and Severe Aortic Valve Stenosis

Al-Hijji, M., Narula, N., Go, J. L., Khosla, S., Sarano, M. E., Loeffler, D., Lennon, R., Lerman, L. O. & Lerman, A., Apr 1 2019, In : Mayo Clinic proceedings. 94, 4, p. 652-659 8 p.

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Stem Cells
Phenotype
Vascular Endothelial Growth Factor Receptor-2
Aortic Valve
13 Citations (Scopus)

Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study

Samelson, E. J., Broe, K. E., Xu, H., Yang, L., Boyd, S., Biver, E., Szulc, P., Adachi, J., Amin, S., Atkinson, E., Berger, C., Burt, L., Chapurlat, R., Chevalley, T., Ferrari, S., Goltzman, D., Hanley, D. A., Hannan, M. T., Khosla, S., Liu, C. T. & 13 others, Lorentzon, M., Mellstrom, D., Merle, B., Nethander, M., Rizzoli, R., Sornay-Rendu, E., Van Rietbergen, B., Sundh, D., Wong, A. K. O., Ohlsson, C., Demissie, S., Kiel, D. P. & Bouxsein, M. L., Jan 1 2019, In : The Lancet Diabetes and Endocrinology. 7, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

Bone Density
Prospective Studies
Bone and Bones
Femur Neck
Tibia
Open Access
Wnt Signaling Pathway
Osteoclasts
Minerals
Bone and Bones
Research
1 Citation (Scopus)

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Farr, J. N., Rowsey, J. L., Eckhardt, B. A., Thicke, B. S., Fraser, D. G., Tchkonia, T., Kirkland, J. L., Monroe, D. G. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 8, p. 1407-1418 12 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Young Adult
Estrogens
Bone and Bones
1 Citation (Scopus)

Is It Time to Stop (or Pause) Vertebral Augmentation?

Clarke, B. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Personalising osteoporosis treatment for patients at high risk of fracture

Khosla, S., Oct 1 2019, In : The Lancet Diabetes and Endocrinology. 7, 10, p. 739-741 3 p.

Research output: Contribution to journalComment/debate

Osteoporosis
Therapeutics
1 Citation (Scopus)

Translation to Practice: Accelerating the Cycle of Innovation to Impact

Anderson, J. R., Chung, T. D. Y., Clark, L., Weis, J. A., Danielsen, A. J., Khosla, S., Gores, G. J. & Badley, A. D., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journalReview article

Biological Factors
Practice Guidelines
Physicians
Equipment and Supplies
Pharmaceutical Preparations

Virtual supersampling as post-processing step preserves the trabecular bone morphometry in human peripheral quantitative computed tomography scans

Schulte, F. A., Christen, P., Badilatti, S. D., Parkinson, I., Khosla, S., Goldhahn, J. & Müller, R., Feb 1 2019, In : PloS one. 14, 2, e0212280.

Research output: Contribution to journalArticle

Open Access
morphometry
computed tomography
Tomography
preserves
Bone
2018

Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel

Sampson, U. K. A., McGlynn, E. A., Perlin, J. B., Frisse, M. E., Arnold, S. B., Benz, E. J., Brennan, T., Briss, P., Beeuwkes Buntin, M. J., Khosla, S., King, R. G., Kuntz, R., Leider, H., Ling, S. M., Macrae, J., Murray, R., Thrailkill, E., Wager, C., Witchey, D. & Jacobson, H. R., Jan 1 2018, (Accepted/In press) In : Global Heart.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Delivery of Health Care
Health Services
Public-Private Sector Partnerships
Government Agencies
2 Citations (Scopus)

Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study

Lee, T. H., Setty, P. T., Parthasarathy, G., Bailey, K. R., Wood-Wentz, C. M., Fletcher, J. G., Takahashi, N. M., Khosla, S., Moynagh, M. R., Zinsmeister, A. R. & Bharucha, A. E., Sep 1 2018, In : Mayo Clinic Proceedings. 93, 9, p. 1256-1265 10 p.

Research output: Contribution to journalArticle

Diverticulitis
Obesity
Incidence
Body Mass Index
Population
4 Citations (Scopus)

Evaluation of cross-sectional and longitudinal changes in volumetric bone mineral density in postmenopausal women using single- versus dual-energy quantitative computed tomography

Sfeir, J. G., Drake, M. M., Atkinson, E. J., Achenbach, S. J., Camp, J. J., Tweed, A. J., McCready, L. K., Yu, L., Adkins, M. C., Amin, S. & Khosla, S., Jul 1 2018, In : Bone. 112, p. 145-152 8 p.

Research output: Contribution to journalArticle

Bone Density
Bone Marrow
Tomography
Fats
Bone and Bones
4 Citations (Scopus)

Factors associated with proximal femur fracture determined in a large cadaveric cohort

Dragomir Daescu, M. D., Rossman, T. L., Rezaei, A., Carlson, K. D., Kallmes, D. F., Skinner, J. A., Khosla, S. & Amin, S., Nov 1 2018, In : Bone. 116, p. 196-202 7 p.

Research output: Contribution to journalArticle

Hip Fractures
Femur
Bone Density
Thigh
Neck

Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes

Rianon, N. J., Smith, S. M., Lee, M. J., Pervin, H., Musgrave, P., Watt, G. P., Nader, S., Khosla, S., Ambrose, C. G., McCormick, J. B. & Fisher-Hoch, S. P., Jan 1 2018, In : Journal of Osteoporosis. 2018, 7153021.

Research output: Contribution to journalArticle

Bone Remodeling
Type 2 Diabetes Mellitus
Osteocalcin
Hispanic Americans
Serum
18 Citations (Scopus)
Cell Aging
Osteoporosis
Bone
Aging of materials
Bone and Bones
3 Citations (Scopus)

miR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss

Aquino-Martinez, R., Farr, J., Weivoda, M., Negley, B. A., Onken, J. L., Thicke, B. S., Fulcer, M. M., Fraser, D. G., van Wijnen, A. J., Khosla, S. & Monroe, D. G., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Osteoblasts
Osteoporosis
Bone and Bones
MicroRNAs
Retinoic Acid Receptors
4 Citations (Scopus)

Net ankle quasi-stiffness is influenced by walking speed but not age for older adult women

Collins, J. D., Arch, E. S., Crenshaw, J. R., Bernhardt, K. A., Khosla, S., Amin, S. & Kaufman, K. R., May 1 2018, In : Gait and Posture. 62, p. 311-316 6 p.

Research output: Contribution to journalArticle

Ankle
Foot Orthoses
Gait
Independent Living
Walking Speed
10 Citations (Scopus)

Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans: The Fracture, Osteoporosis, and CT Utilization Study (FOCUS)

Adams, A. L., Fischer, H., Kopperdahl, D. L., Lee, D. C., Black, D. M., Bouxsein, M. L., Fatemi, S., Khosla, S., Orwoll, E. S., Siris, E. S. & Keaveny, T. M., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Photon Absorptiometry
Hip Fractures
Osteoporosis
Pelvic Bones
Tomography
4 Citations (Scopus)

Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice

Farr, J., Weivoda, M., Nicks, K. M., Fraser, D. G., Negley, B. A., Onken, J. L., Thicke, B. S., Ruan, M., Liu, H., Forrest, D., Hawse, J. R., Khosla, S. & Monroe, D. G., Apr 1 2018, In : Journal of Bone and Mineral Research. 33, 4, p. 720-731 12 p.

Research output: Contribution to journalArticle

Transcription Factors
Osteogenesis
TCF Transcription Factors
Osteoprotegerin
Bone and Bones
1 Citation (Scopus)

Proceedings of the 2018 Santa Fe Bone Symposium: Advances in the Management of Osteoporosis

Lewiecki, E. M., Bilezikian, J. P., Giangregorio, L., Greenspan, S. L., Khosla, S., Kostenuik, P., Krohn, K., McClung, M. R., Miller, P. D. & Pacifici, R., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Densitometry.

Research output: Contribution to journalArticle

Osteoporosis
Bone and Bones
Parathyroid Hormone
Practice Guidelines
Health
18 Citations (Scopus)

Regulation of bone metabolism by sex steroids

Khosla, S. & Monroe, D. G., Jan 1 2018, In : Cold Spring Harbor perspectives in medicine. 8, 1, a031211.

Research output: Contribution to journalReview article

Metabolism
Bone
Estrogens
Steroids
Bone and Bones
152 Citations (Scopus)

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J., Weigand, B. M., Palmer, A. K., Weivoda, M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Health
Tissue
Cell Aging
Quercetin
Pathology
1 Citation (Scopus)

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

Jankowski, C. M., Wolfe, P., Schmiege, S. J., Nair, K. S., Khosla, S., Jensen, M. D., von Muhlen, D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R., Weiss, E. P., Villareal, D. T. & Kohrt, W. M., Jan 1 2018, (Accepted/In press) In : Clinical Endocrinology.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Body Composition
Bone Density
Clinical Trials
Fats
1 Citation (Scopus)

Sex steroids and the pathogenesis of osteoporosis

Drake, M. M. & Khosla, S., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 412-418 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteoblasts
Osteoporosis
Steroids
Bone
Estrogens
7 Citations (Scopus)

Sympathetic β1-adrenergic signaling contributes to regulation of human bone metabolism

Khosla, S., Drake, M. M., Volkman, T. L., Thicke, B. S., Achenbach, S. J., Atkinson, E. J., Joyner, M. J., Rosen, C. J., Monroe, D. G. & Farr, J., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4832-4842 11 p.

Research output: Contribution to journalArticle

Adrenergic Agents
Nebivolol
Bone and Bones
Propranolol
Atenolol
4 Citations (Scopus)

The relationships between compensatory stepping thresholds and measures of gait, standing postural control, strength, and balance confidence in older women

Crenshaw, J. R., Bernhardt, K. A., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Sep 1 2018, In : Gait and Posture. 65, p. 74-80 7 p.

Research output: Contribution to journalArticle

Gait
Independent Living
Body Size
Biomechanical Phenomena
Maintenance

The trabecular effect: A population-based longitudinal study on age and sex differences in bone mineral density and vertebral load bearing capacity

Oppenheimer-Velez, M. L., Giambini, H., Rezaei, A., Camp, J. J., Khosla, S. & Lu, L., Jun 1 2018, In : Clinical Biomechanics. 55, p. 73-78 6 p.

Research output: Contribution to journalArticle

Weight-Bearing
Sex Characteristics
Bone Density
Longitudinal Studies
Population
10 Citations (Scopus)

Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression

Bauer, D. C., Black, D. M., Bouxsein, M. L., Lui, L. Y., Cauley, J. A., de Papp, A. E., Grauer, A., Khosla, S., Mcculloch, C. E. & Eastell, R., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Fracture Fixation
Bone Remodeling
Bone Fractures
Risk Reduction Behavior
Clinical Trials
1 Citation (Scopus)

Validation of a novel, rapid, high precision sclerostin assay not confounded by sclerostin fragments

Drake, M. M., Fenske, J. S., Blocki, F. A., Zierold, C., Appelman-Dijkstra, N., Papapoulos, S. & Khosla, S., Jun 1 2018, In : Bone. 111, p. 36-43 8 p.

Research output: Contribution to journalArticle

Serum
Teriparatide
Luminescent Measurements
Bone and Bones
Osteocytes
2017
50 Citations (Scopus)

Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward

Khosla, S., Cauley, J. A., Compston, J., Kiel, D. P., Rosen, C., Saag, K. G. & Shane, E., Mar 1 2017, In : Journal of Bone and Mineral Research. 32, 3, p. 424-430 7 p.

Research output: Contribution to journalArticle

Osteoporosis
Femur
Photon Absorptiometry
Therapeutics
Bone Density Conservation Agents
9 Citations (Scopus)

Bone diseases: Romosozumab-on track or derailed?

Khosla, S., Dec 1 2017, In : Nature Reviews Endocrinology. 13, 12, p. 697-698 2 p.

Research output: Contribution to journalShort survey

Bone Diseases
AMG 785
35 Citations (Scopus)

Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned

Drake, M. M., Clarke, B., Oursler, M. J. & Khosla, S., Aug 1 2017, In : Endocrine Reviews. 38, 4, p. 325-350 26 p.

Research output: Contribution to journalReview article

Cathepsin K
Osteoporosis
Osteoclasts
Cathepsins
Bone Density
9 Citations (Scopus)

Circulating osteogenic endothelial progenitor cell counts: new biomarker for the severity of coronary artery disease

Yang, S. W., Hennessy, R. R., Khosla, S., Lennon, R., Loeffler, D., Sun, T., Liu, Z., Park, K. H., Wang, F. L., Lerman, L. O. & Lerman, A., Jan 15 2017, In : International Journal of Cardiology. 227, p. 833-839 7 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Cell Count
Biomarkers
Coronary Stenosis
Cause of Death
1 Citation (Scopus)

Clinical, cellular, microscopic, and ultrastructural studies of a case of fibrogenesis imperfecta ossium

Barron, M. L., Rybchyn, M. S., Ramesh, S., Mason, R. S., Fiona Bonar, S., Stalley, P., Khosla, S., Hudson, B., Arthur, C., Kim, E., Clifton-Bligh, R. J. & Clifton-Bligh, P. B., Mar 14 2017, In : Bone Research. 5, 16057.

Research output: Contribution to journalArticle

Osteoblasts
Bone and Bones
Up-Regulation
Osteosclerosis
Aquaporin 1
4 Citations (Scopus)

Fracture Incidence and Characteristics in Young Adults Aged 18 to 49 Years: A Population-Based Study

Farr, J., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Khosla, S. & Amin, S., Dec 1 2017, In : Journal of Bone and Mineral Research. 32, 12, p. 2347-2354 8 p.

Research output: Contribution to journalArticle

Young Adult
Incidence
Wounds and Injuries
Population
Pediatrics
21 Citations (Scopus)

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Jafari, A., Qanie, D., Andersen, T. L., Zhang, Y., Chen, L., Postert, B., Parsons, S., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaisse, J. M., Abdallah, B. M., Hesselson, D., Solberg, R. & Kassem, M., Feb 14 2017, In : Stem Cell Reports. 8, 2, p. 373-386 14 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Postmenopausal Osteoporosis
Mesenchymal Stromal Cells
Bone
Osteoblasts
4 Citations (Scopus)

New hope for symptom management during natural and iatrogenic menopause transitions

Woodruff, T. K. & Khosla, S., Aug 1 2017, In : Biology of Reproduction. 97, 2, p. 177-178 2 p.

Research output: Contribution to journalArticle

Menopause
Bone and Bones
Gonadal Hormones
Peptide Hormones
Estrogens
77 Citations (Scopus)

Osteoporosis treatment: Recent developments and ongoing challenges

Khosla, S. & Hofbauer, L. C., 2017, (Accepted/In press) In : The Lancet Diabetes and Endocrinology.

Research output: Contribution to journalArticle

Osteoporosis
Diphosphonates
Pharmaceutical Preparations
Estrogens
Teriparatide

Response to Stoecker et al

Khosla, S. & Shane, E., Jun 1 2017, In : Journal of Bone and Mineral Research. 32, 6, p. 1388 1 p.

Research output: Contribution to journalLetter

128 Citations (Scopus)

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Bone
Bone and Bones
Caspase 8
9 Citations (Scopus)

The circumstances, orientations, and impact locations of falls in community-dwelling older women

Crenshaw, J. R., Bernhardt, K. A., Achenbach, S. J., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Nov 1 2017, In : Archives of Gerontology and Geriatrics. 73, p. 240-247 8 p.

Research output: Contribution to journalArticle

Independent Living
Wrist
Pelvis
Hip
Accidental Falls
9 Citations (Scopus)

The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions

Bonaretti, S., Majumdar, S., Lang, T. F., Khosla, S. & Burghardt, A. J., Apr 8 2017, (Accepted/In press) In : Osteoporosis International. p. 1-14 14 p.

Research output: Contribution to journalArticle

Tomography
Bone and Bones
Extremities
Tibia
Anatomic Landmarks
4 Citations (Scopus)

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the United States: supplementary presentation

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Sep 21 2017, (Accepted/In press) In : Osteoporosis International. p. 1-2 2 p.

Research output: Contribution to journalArticle

Insurance Pools
Osteoporosis
Bone and Bones
Humerus
Hip Fractures
2016
108 Citations (Scopus)

A Crisis in the Treatment of Osteoporosis

Khosla, S. & Shane, E., Aug 1 2016, In : Journal of Bone and Mineral Research. 31, 8, p. 1485-1487 3 p.

Research output: Contribution to journalEditorial

Osteoporosis

Bone quality in type 2 diabetes mellitus

Farr, J. & Khosla, S., Jan 1 2016, Diabetic Bone Disease: Basic and Translational Research and Clinical Applications. Springer International Publishing, p. 211-224 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Type 2 Diabetes Mellitus
Bone and Bones
Osteogenesis
Advanced Glycosylation End Products
Premature Mortality
25 Citations (Scopus)

Comprehensive assessment of osteoporosis and bone fragility with ct colonography

Fidler, J. L., Murthy, N. S., Khosla, S., Clarke, B., Bruining, D. H., Kopperdahl, D. L., Lee, D. C. & Keaveny, T. M., Jan 1 2016, In : Radiology. 278, 1, p. 172-180 9 p.

Research output: Contribution to journalArticle

Osteoporosis
X-Rays
Bone and Bones
Computed Tomographic Colonography
Confidence Intervals
60 Citations (Scopus)

Determinants of bone strength and quality in diabetes mellitus in humans

Farr, J. & Khosla, S., Jan 1 2016, In : Bone. 82, p. 28-34 7 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Diabetes Mellitus
Bone and Bones
Porosity
Bone Remodeling
18 Citations (Scopus)

Hormonal and systemic regulation of sclerostin

Drake, M. M. & Khosla, S., Jul 28 2016, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

Catenins
Hindlimb Suspension
Bone and Bones
Osteocytes
Wnt Signaling Pathway
64 Citations (Scopus)

Identification of Senescent Cells in the Bone Microenvironment

Farr, J., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M., Drake, M. M., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L. F., Pignolo, R., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

Osteocytes
Bone and Bones
Phenotype
Satellite DNA
Cell Aging