• 39856 Citations
  • 101 Scopus h-Index
1976 …2021

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Article
2020

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Weivoda, M. M., Chew, C. K., Monroe, D. G., Farr, J. N., Atkinson, E. J., Geske, J. R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A. J., McCready, L. K., Rizza, R. A., Matveyenko, A., Kassem, M., Andersen, T. L., Vella, A., Drake, M. T., Clarke, B. L., Oursler, M. J. & Khosla, S., Dec 1 2020, In : Nature communications. 11, 1, 87.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis

Aquino-Martinez, R., Rowsey, J. L., Fraser, D. G., Eckhardt, B. A., Khosla, S., Farr, J. N. & Monroe, D. G., Mar 2020, In : Bone. 132, 115220.

Research output: Contribution to journalArticle

Posterior single-stepping thresholds are prospectively related to falls in older women

Crenshaw, J. R., Bernhardt, K. A., Atkinson, E. J., Achenbach, S. J., Khosla, S., Amin, S. & Kaufman, K. R., Jan 1 2020, (Accepted/In press) In : Aging Clinical and Experimental Research.

Research output: Contribution to journalArticle

Unsupervised machine learning for the discovery of latent disease clusters and patient subgroups using electronic health records

Wang, Y., Zhao, Y., Therneau, T. M., Atkinson, E. J., Tafti, A. P., Zhang, N., Amin, S., Limper, A. H., Khosla, S. & Liu, H., Feb 2020, In : Journal of Biomedical Informatics. 102, 103364.

Research output: Contribution to journalArticle

2019
1 Scopus citations

Cellular senescence in bone

Farr, J. & Khosla, S., Apr 1 2019, In : Bone. 121, p. 121-133 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Circulating Osteogenic Progenitor Cells in Mild, Moderate, and Severe Aortic Valve Stenosis

Al-Hijji, M., Narula, N., Go, J. L., Khosla, S., Sarano, M. E., Loeffler, D., Lennon, R., Lerman, L. O. & Lerman, A., Apr 1 2019, In : Mayo Clinic proceedings. 94, 4, p. 652-659 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study

Samelson, E. J., Broe, K. E., Xu, H., Yang, L., Boyd, S., Biver, E., Szulc, P., Adachi, J., Amin, S., Atkinson, E., Berger, C., Burt, L., Chapurlat, R., Chevalley, T., Ferrari, S., Goltzman, D., Hanley, D. A., Hannan, M. T., Khosla, S., Liu, C. T. & 13 others, Lorentzon, M., Mellstrom, D., Merle, B., Nethander, M., Rizzoli, R., Sornay-Rendu, E., Van Rietbergen, B., Sundh, D., Wong, A. K. O., Ohlsson, C., Demissie, S., Kiel, D. P. & Bouxsein, M. L., Jan 1 2019, In : The Lancet Diabetes and Endocrinology. 7, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Farr, J. N., Rowsey, J. L., Eckhardt, B. A., Thicke, B. S., Fraser, D. G., Tchkonia, T., Kirkland, J. L., Monroe, D. G. & Khosla, S., Jan 1 2019, In : Journal of Bone and Mineral Research. 34, 8, p. 1407-1418 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Virtual supersampling as post-processing step preserves the trabecular bone morphometry in human peripheral quantitative computed tomography scans

Schulte, F. A., Christen, P., Badilatti, S. D., Parkinson, I., Khosla, S., Goldhahn, J. & Müller, R., Feb 1 2019, In : PloS one. 14, 2, e0212280.

Research output: Contribution to journalArticle

Open Access
2018

Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel

Sampson, U. K. A., McGlynn, E. A., Perlin, J. B., Frisse, M. E., Arnold, S. B., Benz, E. J., Brennan, T., Briss, P., Beeuwkes Buntin, M. J., Khosla, S., King, R. G., Kuntz, R., Leider, H., Ling, S. M., Macrae, J., Murray, R., Thrailkill, E., Wager, C., Witchey, D. & Jacobson, H. R., Jan 1 2018, (Accepted/In press) In : Global Heart.

Research output: Contribution to journalArticle

Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study

Lee, T. H., Setty, P. T., Parthasarathy, G., Bailey, K. R., Wood-Wentz, C. M., Fletcher, J. G., Takahashi, N. M., Khosla, S., Moynagh, M. R., Zinsmeister, A. R. & Bharucha, A. E., Sep 1 2018, In : Mayo Clinic Proceedings. 93, 9, p. 1256-1265 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Evaluation of cross-sectional and longitudinal changes in volumetric bone mineral density in postmenopausal women using single- versus dual-energy quantitative computed tomography

Sfeir, J. G., Drake, M. M., Atkinson, E. J., Achenbach, S. J., Camp, J. J., Tweed, A. J., McCready, L. K., Yu, L., Adkins, M. C., Amin, S. & Khosla, S., Jul 1 2018, In : Bone. 112, p. 145-152 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Factors associated with proximal femur fracture determined in a large cadaveric cohort

Dragomir Daescu, M. D., Rossman, T. L., Rezaei, A., Carlson, K. D., Kallmes, D. F., Skinner, J. A., Khosla, S. & Amin, S., Nov 1 2018, In : Bone. 116, p. 196-202 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes

Rianon, N. J., Smith, S. M., Lee, M. J., Pervin, H., Musgrave, P., Watt, G. P., Nader, S., Khosla, S., Ambrose, C. G., McCormick, J. B. & Fisher-Hoch, S. P., Jan 1 2018, In : Journal of Osteoporosis. 2018, 7153021.

Research output: Contribution to journalArticle

1 Scopus citations
26 Scopus citations

miR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss

Aquino-Martinez, R., Farr, J., Weivoda, M., Negley, B. A., Onken, J. L., Thicke, B. S., Fulcer, M. M., Fraser, D. G., van Wijnen, A. J., Khosla, S. & Monroe, D. G., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

8 Scopus citations

Net ankle quasi-stiffness is influenced by walking speed but not age for older adult women

Collins, J. D., Arch, E. S., Crenshaw, J. R., Bernhardt, K. A., Khosla, S., Amin, S. & Kaufman, K. R., May 1 2018, In : Gait and Posture. 62, p. 311-316 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans: The Fracture, Osteoporosis, and CT Utilization Study (FOCUS)

Adams, A. L., Fischer, H., Kopperdahl, D. L., Lee, D. C., Black, D. M., Bouxsein, M. L., Fatemi, S., Khosla, S., Orwoll, E. S., Siris, E. S. & Keaveny, T. M., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

15 Scopus citations

Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice

Farr, J., Weivoda, M., Nicks, K. M., Fraser, D. G., Negley, B. A., Onken, J. L., Thicke, B. S., Ruan, M., Liu, H., Forrest, D., Hawse, J. R., Khosla, S. & Monroe, D. G., Apr 1 2018, In : Journal of Bone and Mineral Research. 33, 4, p. 720-731 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Proceedings of the 2018 Santa Fe Bone Symposium: Advances in the Management of Osteoporosis

Lewiecki, E. M., Bilezikian, J. P., Giangregorio, L., Greenspan, S. L., Khosla, S., Kostenuik, P., Krohn, K., McClung, M. R., Miller, P. D. & Pacifici, R., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Densitometry.

Research output: Contribution to journalArticle

1 Scopus citations

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J., Weigand, B. M., Palmer, A. K., Weivoda, M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

215 Scopus citations

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

Jankowski, C. M., Wolfe, P., Schmiege, S. J., Nair, K. S., Khosla, S., Jensen, M. D., von Muhlen, D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R., Weiss, E. P., Villareal, D. T. & Kohrt, W. M., Jan 1 2018, (Accepted/In press) In : Clinical Endocrinology.

Research output: Contribution to journalArticle

1 Scopus citations

Sympathetic β1-adrenergic signaling contributes to regulation of human bone metabolism

Khosla, S., Drake, M. M., Volkman, T. L., Thicke, B. S., Achenbach, S. J., Atkinson, E. J., Joyner, M. J., Rosen, C. J., Monroe, D. G. & Farr, J., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4832-4842 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The relationships between compensatory stepping thresholds and measures of gait, standing postural control, strength, and balance confidence in older women

Crenshaw, J. R., Bernhardt, K. A., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Sep 1 2018, In : Gait and Posture. 65, p. 74-80 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

The trabecular effect: A population-based longitudinal study on age and sex differences in bone mineral density and vertebral load bearing capacity

Oppenheimer-Velez, M. L., Giambini, H., Rezaei, A., Camp, J. J., Khosla, S. & Lu, L., Jun 1 2018, In : Clinical Biomechanics. 55, p. 73-78 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression

Bauer, D. C., Black, D. M., Bouxsein, M. L., Lui, L. Y., Cauley, J. A., de Papp, A. E., Grauer, A., Khosla, S., Mcculloch, C. E. & Eastell, R., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

12 Scopus citations

Validation of a novel, rapid, high precision sclerostin assay not confounded by sclerostin fragments

Drake, M. M., Fenske, J. S., Blocki, F. A., Zierold, C., Appelman-Dijkstra, N., Papapoulos, S. & Khosla, S., Jun 1 2018, In : Bone. 111, p. 36-43 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward

Khosla, S., Cauley, J. A., Compston, J., Kiel, D. P., Rosen, C., Saag, K. G. & Shane, E., Mar 1 2017, In : Journal of Bone and Mineral Research. 32, 3, p. 424-430 7 p.

Research output: Contribution to journalArticle

65 Scopus citations

Circulating osteogenic endothelial progenitor cell counts: new biomarker for the severity of coronary artery disease

Yang, S. W., Hennessy, R. R., Khosla, S., Lennon, R., Loeffler, D., Sun, T., Liu, Z., Park, K. H., Wang, F. L., Lerman, L. O. & Lerman, A., Jan 15 2017, In : International Journal of Cardiology. 227, p. 833-839 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Clinical, cellular, microscopic, and ultrastructural studies of a case of fibrogenesis imperfecta ossium

Barron, M. L., Rybchyn, M. S., Ramesh, S., Mason, R. S., Fiona Bonar, S., Stalley, P., Khosla, S., Hudson, B., Arthur, C., Kim, E., Clifton-Bligh, R. J. & Clifton-Bligh, P. B., Mar 14 2017, In : Bone Research. 5, 16057.

Research output: Contribution to journalArticle

2 Scopus citations

Fracture Incidence and Characteristics in Young Adults Aged 18 to 49 Years: A Population-Based Study

Farr, J., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Khosla, S. & Amin, S., Dec 1 2017, In : Journal of Bone and Mineral Research. 32, 12, p. 2347-2354 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Jafari, A., Qanie, D., Andersen, T. L., Zhang, Y., Chen, L., Postert, B., Parsons, S., Ditzel, N., Khosla, S., Johansen, H. T., Kjærsgaard-Andersen, P., Delaisse, J. M., Abdallah, B. M., Hesselson, D., Solberg, R. & Kassem, M., Feb 14 2017, In : Stem Cell Reports. 8, 2, p. 373-386 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

New hope for symptom management during natural and iatrogenic menopause transitions

Woodruff, T. K. & Khosla, S., Aug 1 2017, In : Biology of Reproduction. 97, 2, p. 177-178 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

Osteoporosis treatment: Recent developments and ongoing challenges

Khosla, S. & Hofbauer, L. C., 2017, (Accepted/In press) In : The Lancet Diabetes and Endocrinology.

Research output: Contribution to journalArticle

112 Scopus citations

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

169 Scopus citations

The circumstances, orientations, and impact locations of falls in community-dwelling older women

Crenshaw, J. R., Bernhardt, K. A., Achenbach, S. J., Atkinson, E. J., Khosla, S., Kaufman, K. R. & Amin, S., Nov 1 2017, In : Archives of Gerontology and Geriatrics. 73, p. 240-247 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions

Bonaretti, S., Majumdar, S., Lang, T. F., Khosla, S. & Burghardt, A. J., Apr 8 2017, (Accepted/In press) In : Osteoporosis International. p. 1-14 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the United States: supplementary presentation

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Sep 21 2017, (Accepted/In press) In : Osteoporosis International. p. 1-2 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Comprehensive assessment of osteoporosis and bone fragility with ct colonography

Fidler, J. L., Murthy, N. S., Khosla, S., Clarke, B., Bruining, D. H., Kopperdahl, D. L., Lee, D. C. & Keaveny, T. M., Jan 1 2016, In : Radiology. 278, 1, p. 172-180 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Determinants of bone strength and quality in diabetes mellitus in humans

Farr, J. & Khosla, S., Jan 1 2016, In : Bone. 82, p. 28-34 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

Hormonal and systemic regulation of sclerostin

Drake, M. M. & Khosla, S., Jul 28 2016, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

23 Scopus citations

Identification of Senescent Cells in the Bone Microenvironment

Farr, J., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M., Drake, M. M., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L. F., Pignolo, R., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Microarchitecture and Peripheral BMD are Impaired in Postmenopausal White Women with Fracture Independently of Total Hip T-Score: An International Multicenter Study

Boutroy, S., Khosla, S., Sornay-Rendu, E., Zanchetta, M. B., McMahon, D. J., Zhang, C. A., Chapurlat, R. D., Zanchetta, J., Stein, E. M., Bogado, C., Majumdar, S., Burghardt, A. J. & Shane, E., Jun 1 2016, In : Journal of Bone and Mineral Research. 31, 6, p. 1158-1166 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training

Bonaretti, S., Vilayphiou, N., Chan, C. M., Yu, A., Nishiyama, K., Liu, D., Boutroy, S., Ghasem-Zadeh, A., Boyd, S. K., Chapurlat, R., McKay, H., Shane, E., Bouxsein, M. L., Black, D. M., Majumdar, S., Orwoll, E. S., Lang, T. F., Khosla, S. & Burghardt, A. J., Jul 30 2016, (Accepted/In press) In : Osteoporosis International. p. 1-13 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

Schafer, M. J., Atkinson, E. J., Vanderboom, P. M., Kotajarvi, B., White, T. A., Moore, M. M., Bruce, C. J., Greason, K. L., Suri, R. M., Khosla, S., Miller, J. D., Bergen, H. R. B. III. & LeBrasseur, N. K., Jun 14 2016, In : Cell Metabolism. 23, 6, p. 1207-1215 9 p.

Research output: Contribution to journalArticle

82 Scopus citations

Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features

Carballido-Gamio, J., Bonaretti, S., Kazakia, G. J., Khosla, S., Majumdar, S., Lang, T. F. & Burghardt, A. J., Nov 9 2016, (Accepted/In press) In : Annals of Biomedical Engineering. p. 1-14 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Technical note: Recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation

Diez-Perez, A., Bouxsein, M. L., Eriksen, E. F., Khosla, S., Nyman, J. S., Papapoulos, S. & Tang, S. Y., Dec 1 2016, In : Bone Reports. 5, p. 181-185 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA

Wright, N. C., Saag, K. G., Dawson-Hughes, B., Khosla, S. & Siris, E. S., Dec 13 2016, (Accepted/In press) In : Osteoporosis International. p. 1-8 8 p.

Research output: Contribution to journalArticle

30 Scopus citations