• 38865 Citations
  • 100 Scopus h-Index
1976 …2021
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Research Output 1980 2019

2011
68 Citations (Scopus)

Association of hip strength estimates by finite-element analysis with fractures in women and men

Amin, S., Kopperdhal, D. L., Melton, L. J., Achenbach, S. J., Therneau, T. M., Riggs, B. L., Keaveny, T. M. & Khosla, S., Jul 2011, In : Journal of Bone and Mineral Research. 26, 7, p. 1593-1600 8 p.

Research output: Contribution to journalArticle

Finite Element Analysis
Hip
Osteoporotic Fractures
Tomography
Femur
42 Citations (Scopus)

Bone microstructural changes revealed by high-resolution peripheral quantitative computed tomography imaging and elevated DKK1 and MIP-1α levels in patients with MGUS

Ng, A. C., Khosla, S., Charatcharoenwitthaya, N., Kumar, S. K., Achenbach, S. J., Holets, M. F., McCready, L. K., Melton, L. J., Kyle, R. A., Rajkumar, S. V. & Drake, M. M., Dec 15 2011, In : Blood. 118, 25, p. 6529-6534 6 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Tomography
Bone
Bone Density
Imaging techniques

Corrigendum to "Circulating osteogenic cells: Characterization and relationship to rates of bone loss in postmenopausal women" [Bone 47 (2010) 83-92]

Undale, A., Srinivasan, B., Drake, M. M., McCready, L., Atkinson, E., Peterson, J., Riggs, B. L., Amin, S., Modder, U. I. & Khosla, S., Mar 1 2011, In : Bone. 48, 3, p. 671 1 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Bone and Bones
corrigendum

Corrigendum to "Letter to the Editor" [Bone 38 (2006) 289]

Khosla, S., Modder, U. I. & Syed, F. A., Mar 1 2011, In : Bone. 48, 3, p. 670 1 p.

Research output: Contribution to journalArticle

Bone and Bones
corrigendum
4 Citations (Scopus)

Determinants of forearm strength in postmenopausal women

Melton, L. J., Riggs, B. L., Müller, R., Achenbach, S. J., Christen, D., Atkinson, E. J., Amin, S. & Khosla, S., Dec 2011, In : Osteoporosis International. 22, 12, p. 3047-3054 8 p.

Research output: Contribution to journalArticle

Forearm
Bone and Bones
Bone Density
Steroids
Tomography
19 Citations (Scopus)

Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone

Syed, F. A., Fraser, D. G., Monroe, D. G. & Khosla, S., Aug 2011, In : Bone. 49, 2, p. 208-216 9 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Bone and Bones
Response Elements
Estrogens
54 Citations (Scopus)

Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women

Mödder, U. I., Roforth, M. M., Hoey, K., McCready, L. K., Peterson, J. M., Monroe, D. G., Oursler, M. J. & Khosla, S., Aug 2011, In : Bone. 49, 2, p. 202-207 6 p.

Research output: Contribution to journalArticle

Estrogens
Cytokines
Bone Marrow
Bone and Bones
Adiponectin
29 Citations (Scopus)

Effects of intermittent parathyroid hormone treatment on osteoprogenitor cells in postmenopausal women

Drake, M. M., Srinivasan, B., Mödder, U. I., Ng, A. C., Undale, A. H., Roforth, M. M., Peterson, J. M., McCready, L. K., Riggs, B. L. & Khosla, S., Sep 2011, In : Bone. 49, 3, p. 349-355 7 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Therapeutics
Vascular Endothelial Growth Factor C
Osteoblasts
Bone Marrow Cells
36 Citations (Scopus)

Effects of physiological variations in circulating insulin levels on bone turnover in humans

Basu, R., Peterson, J., Rizza, R. & Khosla, S., May 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 5, p. 1450-1455 6 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone
Insulin
Osteocalcin
Osteoprotegerin

Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women

Drake, M. M., McCready, L. K., Hoey, K. A., Atkinson, E. J. & Khosla, S., May 2011, In : Obstetrical and Gynecological Survey. 66, 5, p. 289-290 2 p.

Research output: Contribution to journalArticle

Follicle Stimulating Hormone
Bone Resorption
84 Citations (Scopus)

Emerging therapeutic opportunities for skeletal restoration

Kawai, M., Mödder, U. I., Khosla, S. & Rosen, C. J., Feb 2011, In : Nature Reviews Drug Discovery. 10, 2, p. 141-156 16 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone Density
Pharmaceutical Preparations
Teriparatide
Selective Estrogen Receptor Modulators
15 Citations (Scopus)

Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover

Abdallah, B. M., Bay-Jensen, A. C., Srinivasan, B., Tabassi, N. C., Garnero, P., Delaissé, J. M., Khosla, S. & Kassem, M., Oct 2011, In : Journal of Bone and Mineral Research. 26, 10, p. 2548-2551 4 p.

Research output: Contribution to journalArticle

Bone Remodeling
Estrogens
Antigens
Osteocalcin
Bone and Bones
18 Citations (Scopus)

Forum on aging and skeletal health: Summary of the proceedings of an ASBMR workshop

Khosla, S., Bellido, T. M., Drezner, M. K., Gordon, C. M., Harris, T. B., Kiel, D. P., Kream, B. E., Leboff, M. S., Lian, J. B., Peterson, C. A., Rosen, C. J., Williams, J. P., Winer, K. K. & Sherman, S. S., Nov 2011, In : Journal of Bone and Mineral Research. 26, 11, p. 2565-2578 14 p.

Research output: Contribution to journalArticle

Osteoporosis
Education
Bone and Bones
Osteoporotic Fractures
Health
28 Citations (Scopus)

Fracture risk in men with prostate cancer: A population-based study

Melton, L. J., Lieber, M. M., Atkinson, E. J., Achenbach, S. J., Zincke, H., Therneau, T. M. & Khosla, S., Aug 2011, In : Journal of Bone and Mineral Research. 26, 8, p. 1808-1815 8 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Androgens
Population
Spontaneous Fractures
Therapeutics
1 Citation (Scopus)

Getting to the bare bones of fertility

Khosla, S. & Rosen, C., 2011, In : Nature Medicine. 17, 5, p. 550-551 2 p.

Research output: Contribution to journalArticle

Fertility
Bone
Bone and Bones
Osteocalcin
Skeleton
6 Citations (Scopus)

Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations

Cummins, N. W., Klicpera, A., Sainski, A. M., Bren, G. D., Khosla, S., Westendorf, J. J. & Badley, A. D., Sep 12 2011, In : PLoS One. 6, 9, e24876.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus env Gene Products
osteoblasts
Osteoblasts
Human immunodeficiency virus
apoptosis
19 Citations (Scopus)

Induction of fracture repair by mesenchymal cells derived from human embryonic stem cells or bone marrow

Undale, A., Fraser, D., Hefferan, T., Kopher, R. A., Herrick, J., Evans, G. L., Li, X., Kakar, S., Hayes, M., Atkinson, E., Yaszemski, M. J., Kaufman, D. S., Westendorf, J. J. & Khosla, S., Dec 2011, In : Journal of Orthopaedic Research. 29, 12, p. 1804-1811 8 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone Marrow
Fracture Healing
Control Groups
Human Embryonic Stem Cells
15 Citations (Scopus)

Is nitroglycerin a novel and inexpensive treatment for osteoporosis?

Khosla, S., Feb 23 2011, In : JAMA - Journal of the American Medical Association. 305, 8, p. 826-827 2 p.

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Postmenopause
Nitric Oxide Donors
Bone Fractures
Nitroglycerin
68 Citations (Scopus)

Is vitamin D a determinant of muscle mass and strength?

Marantes, I., Achenbach, S. J., Atkinson, E. J., Khosla, S., Melton, L. J. & Amin, S., Dec 2011, In : Journal of Bone and Mineral Research. 26, 12, p. 2860-2871 12 p.

Research output: Contribution to journalArticle

Muscle Strength
Parathyroid Hormone
Vitamin D
Knee
Linear Models
30 Citations (Scopus)

Nonoxidative free fatty acid disposal is greater in young women than men

Koutsari, C., Basu, R., Rizza, R. A., Nair, K. S., Khosla, S. & Jensen, M. D., Feb 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 2, p. 541-547 7 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Insulin Resistance
Insulin
Fatty Acids
Oxidation
1029 Citations (Scopus)

Osteoporosis: Now and the future

Rachner, T. D., Khosla, S. & Hofbauer, L. C., Apr 9 2011, In : The Lancet. 377, 9773, p. 1276-1287 12 p.

Research output: Contribution to journalArticle

Osteoporosis
Osteoclasts
Bone and Bones
Osteogenesis
Cathepsin K
19 Citations (Scopus)

Osteoporosis Update From the 2010 Santa Fe Bone Symposium

Lewiecki, E. M., Bilezikian, J. P., Khosla, S., Marcus, R., McClung, M. R., Miller, P. D., Watts, N. B. & Maricic, M., Jan 2011, In : Journal of Clinical Densitometry. 14, 1, p. 1-21 21 p.

Research output: Contribution to journalArticle

Osteoporosis
Metabolic Bone Diseases
Bone and Bones
Biomedical Technology Assessment
Fracture Healing
146 Citations (Scopus)

Regulation of circulating sclerostin levels by sex steroids in women and in men

Mödder, U. I., Clowes, J. A., Hoey, K., Peterson, J. M., McCready, L., Oursler, M. J., Riggs, B. L. & Khosla, S., Jan 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

Steroids
Bone Resorption
Bone Remodeling
Collagen Type I
Serum
237 Citations (Scopus)

Relation of age, gender, and bone mass to circulating sclerostin levels in women and men

Mödder, U. I., Hoey, K. A., Amin, S., McCready, L. K., Achenbach, S. J., Riggs, B. L., Melton, L. J. & Khosla, S., Feb 2011, In : Journal of Bone and Mineral Research. 26, 2, p. 373-379 7 p.

Research output: Contribution to journalArticle

Interpersonal Relations
Bone and Bones
Serum
Estrogens
Osteogenesis
54 Citations (Scopus)

Relationship of testosterone and osteocalcin levels during growth

Kirmani, S., Atkinson, E. J., Melton, L. J., Riggs, B. L., Amin, S. & Khosla, S., Sep 2011, In : Journal of Bone and Mineral Research. 26, 9, p. 2212-2216 5 p.

Research output: Contribution to journalArticle

Osteocalcin
Testosterone
Bone and Bones
Growth
Testis
130 Citations (Scopus)

Robust QCT/FEA models of proximal femur stiffness and fracture load during a sideways fall on the hip

Dragomir Daescu, M. D., Op Den Buijs, J., McEligot, S., Dai, Y., Entwistle, R. C., Salas, C., Melton, L. J., Bennet, K. E., Khosla, S. & Amin, S., Feb 2011, In : Annals of Biomedical Engineering. 39, 2, p. 742-755 14 p.

Research output: Contribution to journalArticle

Tomography
Loads (forces)
Stiffness
Finite element method
Bone
18 Citations (Scopus)

The bone and beyond: A shift in calcium

Khosla, S., Apr 2011, In : Nature Medicine. 17, 4, p. 430-431 2 p.

Research output: Contribution to journalArticle

Bone
Aging of materials
Calcium
59 Citations (Scopus)

The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors

Nelson, E. R., DuSell, C. D., Wang, X., Howe, M. K., Evans, G., Michalek, R. D., Umetani, M., Rathmell, J. C., Khosla, S., Gesty-Palmer, D. & McDonnell, D. P., Dec 2011, In : Endocrinology. 152, 12, p. 4691-4705 15 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Homeostasis
Osteoblasts
Cholesterol
179 Citations (Scopus)

The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: Is a revision needed?

Khosla, S., Melton, L. J. & Riggs, B. L., Mar 2011, In : Journal of Bone and Mineral Research. 26, 3, p. 441-451 11 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Bone and Bones
Postmenopausal Osteoporosis
Age Factors
86 Citations (Scopus)

Towards a diagnostic and therapeutic consensus in male osteoporosis

Kanis, J. A., Bianchi, G., Bilezikian, J. P., Kaufman, J. M., Khosla, S., Orwoll, E. & Seeman, E., Nov 2011, In : Osteoporosis International. 22, 11, p. 2789-2798 10 p.

Research output: Contribution to journalArticle

Osteoporosis
Therapeutics
Education
1 Citation (Scopus)

Trabecular bone deficits among Vietnamese immigrants

Melton, L. J., Marquez, M. A., McCready, L. K., Achenbach, S. J., Riggs, B. L., Amin, S. & Khosla, S., May 2011, In : Osteoporosis International. 22, 5, p. 1627-1631 5 p.

Research output: Contribution to journalArticle

Bone Density
Spine
Estrogens
Bone and Bones
Cancellous Bone
7 Citations (Scopus)

What do we tell our patients about calcium and vitamin D supplementation?

Khosla, S., Jan 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 1, p. 69-71 3 p.

Research output: Contribution to journalArticle

Vitamin D
Calcium
39 Citations (Scopus)

Wnt10b activates the wnt, notch, and NFIκB pathways in u2os osteosarcoma cells

Mödder, U. I., Oursler, M. J., Khosla, S. & Monroe, D. G., May 2011, In : Journal of Cellular Biochemistry. 112, 5, p. 1392-1402 11 p.

Research output: Contribution to journalArticle

Osteosarcoma
Genes
Wnt Signaling Pathway
Chemical activation
Microarrays
2010
106 Citations (Scopus)

Age-dependence of femoral strength in white women and men

Keaveny, T. M., Kopperdahl, D. L., Melton, L. J., Hoffmann, P. F., Amin, S., Riggs, B. L. & Khosla, S., May 2010, In : Journal of Bone and Mineral Research. 25, 5, p. 994-1001 8 p.

Research output: Contribution to journalArticle

Thigh
Bone Density
Femur Neck
Osteoporosis
Bone and Bones
83 Citations (Scopus)

Assessing forearm fracture risk in postmenopausal women

Melton, L. J., Christen, D., Riggs, B. L., Achenbach, S. J., Müller, R., Van Lenthe, G. H., Amin, S., Atkinson, E. J. & Khosla, S., Jul 2010, In : Osteoporosis International. 21, 7, p. 1161-1169 9 p.

Research output: Contribution to journalArticle

Forearm
Bone Density
Odds Ratio
Confidence Intervals
Femur Neck
27 Citations (Scopus)

Circulating osteogenic cells: Characterization and relationship to rates of bone loss in postmenopausal women

Undale, A., Srinivasan, B., Drake, M. M., McCready, L., Atkinson, E., Peterson, J., Riggs, B. L., Amin, S., Moedder, U. I. & Khosla, S., Jul 2010, In : Bone. 47, 1, p. 83-92 10 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Alkaline Phosphatase
Bone Marrow
Bone Marrow Cells
Messenger RNA
63 Citations (Scopus)

Concise review: Insights from normal bone remodeling and stem cell-based therapies for bone repair

Khosla, S., Westendorf, J. J. & Mödder, U. I., Dec 2010, In : Stem Cells. 28, 12, p. 2124-2128 5 p.

Research output: Contribution to journalArticle

Bone Remodeling
Cell- and Tissue-Based Therapy
Stem Cells
Fracture Healing
Bone and Bones
51 Citations (Scopus)

Coronary endothelial dysfunction in humans is associated with coronary retention of osteogenic endothelial progenitor cells

Gössl, M., Mödder, U. I., Gulati, R., Rihal, C., Prasad, A., Loeffler, D., Lerman, L. O., Khosla, S. & Lerman, A., Dec 2010, In : European Heart Journal. 31, 23, p. 2909-2914 6 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Coronary Circulation
Interleukin-8
erucylphosphocholine
Endothelial Progenitor Cells
33 Citations (Scopus)

Effects of chronic estrogen treatment on modulating age-related bone loss in female mice

Syed, F. A., Mödder, U. I., Roforth, M., Hensen, I., Fraser, D. G., Peterson, J. M., Oursler, M. J. & Khosla, S., Nov 2010, In : Journal of Bone and Mineral Research. 25, 11, p. 2438-2446 9 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Spine
Differentiation Antigens
Gene Expression
8 Citations (Scopus)

Effects of estrogen and testosterone on resting energy expenditure in older men

Santosa, S., Khosla, S., McCready, L. K. & Jensen, M. D., Dec 2010, In : Obesity. 18, 12, p. 2392-2394 3 p.

Research output: Contribution to journalArticle

Energy Metabolism
Testosterone
Estrogens
Steroids
Leuprolide
189 Citations (Scopus)

Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women

Drake, M. M., Srinivasan, B., Mödder, U. I., Peterson, J. M., McCready, L. K., Riggs, B. L., Dwyer, D., Stolina, M., Kostenuik, P. & Khosla, S., Nov 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 11, p. 5056-5062 7 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Plasmas
Bone
Bone Marrow
Therapeutics
62 Citations (Scopus)

Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women

Drake, M. M., McCready, L. K., Hoey, K. A., Atkinson, E. J. & Khosla, S., Nov 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 11, p. 5063-5068 6 p.

Research output: Contribution to journalArticle

Follicle Stimulating Hormone
Bone Resorption
Bone
Acid Phosphatase
Gonadotropin-Releasing Hormone
401 Citations (Scopus)

Fat tissue, aging, and cellular senescence

Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D. & Kirkland, J. L., Oct 2010, In : Aging Cell. 9, 5, p. 667-684 18 p.

Research output: Contribution to journalArticle

Cell Aging
Adipocytes
Fats
Phenotype
Adipogenesis
90 Citations (Scopus)

Female reproductive system and bone

Clarke, B. & Khosla, S., Nov 2010, In : Archives of Biochemistry and Biophysics. 503, 1, p. 118-128 11 p.

Research output: Contribution to journalArticle

Bone
Osteoporosis
Bone and Bones
Menopause
Steroids
40 Citations (Scopus)

Human embryonic stem cell-derived CD34+ cells function as MSC progenitor cells

Kopher, R. A., Penchev, V. R., Islam, M. S., Hill, K. L., Khosla, S. & Kaufman, D. S., Oct 2010, In : Bone. 47, 4, p. 718-728 11 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Stem Cells
Human Embryonic Stem Cells
Pluripotent Stem Cells
Endothelial Cells
5 Citations (Scopus)

Modulators of androgen and estrogen receptor activity

Clarke, B. & Khosla, S., 2010, In : Critical Reviews in Eukaryotic Gene Expression. 20, 4, p. 275-294 20 p.

Research output: Contribution to journalArticle

Androgen Receptors
Selective Estrogen Receptor Modulators
Estrogens
Estrogen Receptors
Clinical Trials
124 Citations (Scopus)

Physiology of Bone Loss

Clarke, B. & Khosla, S., May 2010, In : Radiologic Clinics of North America. 48, 3, p. 483-495 13 p.

Research output: Contribution to journalArticle

Bone and Bones
Osteoporosis
Estrogens
Sarcopenia
Postmenopausal Osteoporosis
1 Citation (Scopus)

Placebo-controlled fracture trials in osteoporosis - Comment on the article by Stein and Ray

Rosen, C. J. & Khosla, S., Sep 30 2010, In : New England Journal of Medicine. 363, 14

Research output: Contribution to journalArticle

Osteoporosis
Placebos
16 Citations (Scopus)

Placebo-controlled trials in osteoporosis - Proceeding with caution

Rosen, C. J. & Khosla, S., Sep 30 2010, In : New England Journal of Medicine. 363, 14, p. 1365-1367 3 p.

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Postmenopausal Osteoporosis
Bone Fractures
Osteoporosis
Placebos
64 Citations (Scopus)

Relation of serum serotonin levels to bone density and structural parameters in women

Mödder, U. I., Achenbach, S. J., Amin, S., Riggs, B. L., Melton, L. J. & Khosla, S., Feb 2010, In : Journal of Bone and Mineral Research. 25, 2, p. 415-422 8 p.

Research output: Contribution to journalArticle

Bone Density
Serotonin
Serum
Femur Neck
Bone and Bones