• 38865 Citations
  • 100 Scopus h-Index
1976 …2021
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Research Output 1980 2019

2007
6 Citations (Scopus)

Are the endocrine society's clinical practice guidelines on androgen therapy in women misguided? A commentary-response

Wierman, M., Basson, R., Davis, S., Khosla, S., Miller, K., Rosner, W. & Santoro, N., Nov 2007, In : Journal of Sexual Medicine. 4, 6, p. 1782-1783 2 p.

Research output: Contribution to journalArticle

Practice Guidelines
Androgens
Therapeutics
1162 Citations (Scopus)

Bisphosphonate-associated osteonecrosis of the jaw: Report of a Task Force of the American Society for Bone and Mineral Research

Khosla, S., Burr, D., Cauley, J., Dempster, D. W., Ebeling, P. R., Felsenberg, D., Gagel, R. F., Gilsanz, V., Guise, T., Koka, S., McCauley, L. K., McGowan, J., McKee, M. D., Mohla, S., Pendrys, D. G., Raisz, L. G., Ruggiero, S. L., Shafer, D. M., Shum, L., Silverman, S. L. & 4 others, Van Poznak, C. H., Watts, N., Woo, S. B. & Shane, E., Oct 2007, In : Journal of Bone and Mineral Research. 22, 10, p. 1479-1491 13 p.

Research output: Contribution to journalArticle

Bisphosphonate-Associated Osteonecrosis of the Jaw
Osteonecrosis
Advisory Committees
Jaw
Diphosphonates
105 Citations (Scopus)

Characterization of circulating osteoblast lineage cells in humans

Eghbali-Fatourechi, G. Z., Mödder, U. I. L., Charatcharoenwitthaya, N., Sanyal, A., Undale, A. H., Clowes, J. A., Tarara, J. E. & Khosla, S., May 2007, In : Bone. 40, 5, p. 1370-1377 8 p.

Research output: Contribution to journalArticle

Osteoblasts
Osteocalcin
Population
Alkaline Phosphatase
Bone Remodeling
145 Citations (Scopus)

Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women

Melton, L. J., Riggs, B. L., Van Lenthe, G. H., Achenbach, S. J., Müller, R., Bouxsein, M. L., Amin, S., Atkinson, E. J. & Khosla, S., Sep 2007, In : Journal of Bone and Mineral Research. 22, 9, p. 1442-1448 7 p.

Research output: Contribution to journalArticle

Forearm
Bone and Bones
Colles' Fracture
Osteoporotic Fractures
ROC Curve
1 Citation (Scopus)

Corrigendum to "Characterization of circulating osteoblast lineage cells in humans" [Bone 40 (2007) 1370-1377] (DOI: 10.1016/j.bone.2006.12.064)

Eghbali-Fatourechi, G. Z., Mödder, U. I. L., Charatcharoenwitthaya, N., Sanyal, A., Undale, A. H., Clowes, J. A., Tarara, J. E. & Khosla, S., Oct 2007, In : Bone. 41, 4, p. 741 1 p.

Research output: Contribution to journalArticle

Osteoblasts
Bone and Bones
corrigendum
68 Citations (Scopus)

Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men

Basu, R., Dalla Man, C., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C. & Rizza, R. A., Aug 2007, In : Diabetes Care. 30, 8, p. 1972-1978 7 p.

Research output: Contribution to journalArticle

Testosterone
Insulin
Glucose
Liver
C-Peptide
145 Citations (Scopus)

Effect of blockade of TNF-α and interleukin-1 action on bone resorption in early postmenopausal women

Charatcharoenwitthaya, N., Khosla, S., Atkinson, E. J., McCready, L. K. & Riggs, B. L., May 2007, In : Journal of Bone and Mineral Research. 22, 5, p. 724-729 6 p.

Research output: Contribution to journalArticle

Bone Resorption
Interleukin-1
Interleukin 1 Receptor Antagonist Protein
Estrogens
Serum
22 Citations (Scopus)

Effects of loss of classical estrogen response element signaling on bone in male mice

Syed, F. A., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Krust, A., Chambon, P., Jameson, J. L. & Khosla, S., Apr 2007, In : Endocrinology. 148, 4, p. 1902-1910 9 p.

Research output: Contribution to journalArticle

Response Elements
Estrogen Receptors
Estrogens
Bone and Bones
Bone Density
9 Citations (Scopus)

Effects of testosterone and estradiol on cutaneous vasodilation during local warming in older men

Sokolnicki, L. A., Khosla, S. & Charkoudian, N., Nov 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 293, 5

Research output: Contribution to journalArticle

Vasodilation
Testosterone
Estradiol
Skin
Vasodilator Agents
1 Citation (Scopus)

Erratum: Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women (Diabetes (2007) 56, (753-766))

Basu, R., Man, C. D., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C. & Rizza, R. A., May 2007, In : Diabetes. 56, 5, p. 1486 1 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Insulin
Glucose
Therapeutics
2 Citations (Scopus)

Estrogen therapy and coronary-artery calcification [3]

Hofbauer, L. C., Khosla, S. & Schoppet, M., Sep 20 2007, In : New England Journal of Medicine. 357, 12, p. 1253-1254 2 p.

Research output: Contribution to journalArticle

Calcinosis
Osteoprotegerin
Postmenopausal Osteoporosis
Estrogen Replacement Therapy
Coronary Disease
55 Citations (Scopus)

High serum IGFBP-2 is predictive of increased bone turnover in aging men and women

Amin, S., Riggs, B. L., Melton, L. J., Achenbach, S. J., Atkinson, E. J. & Khosla, S., Jun 2007, In : Journal of Bone and Mineral Research. 22, 6, p. 799-807 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Bone Remodeling
Bone Resorption
Serum
Insulin-Like Growth Factor Binding Proteins
1 Citation (Scopus)

High-trauma fractures and bone mineral density

Khosla, S., Nov 28 2007, In : Journal of the American Medical Association. 298, 20, p. 2418-2419 2 p.

Research output: Contribution to journalArticle

Bone Fractures
Bone Density
Accidents
Wounds and Injuries
1 Citation (Scopus)
Parabiosis
Cell Lineage
Osteoclasts
Collagen Type I
Green Fluorescent Proteins
64 Citations (Scopus)

Osteopenia

Khosla, S. & Melton, L. J., May 31 2007, In : New England Journal of Medicine. 356, 22, p. 2293-2300 8 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Weights and Measures
Femur Neck
Hip Fractures
Wine
117 Citations (Scopus)

Remodeling and vascular spaces in bone

Eriksen, E. F., Eghbali-Fatourechi, G. Z. & Khosla, S., Jan 2007, In : Journal of Bone and Mineral Research. 22, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone and Bones
Intercellular Signaling Peptides and Proteins
Bone Marrow
Confined Spaces
137 Citations (Scopus)

Structural determinants of vertebral fracture risk

Mellon, L. J., Riggs, B. L., Keaveny, T. M., Achenbach, S. J., Hoffmann, P. F., Camp, J. J., Rouleau, P. A., Bouxsein, M. L., Amin, S., Atkinson, E. J., Robb, R. A. & Khosla, S., Dec 2007, In : Journal of Bone and Mineral Research. 22, 12, p. 1885-1892 8 p.

Research output: Contribution to journalArticle

Spine
Bone Density
Bone and Bones
Compressive Strength
Logistic Models
44 Citations (Scopus)

Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women

Basu, R., Man, C. D., Campioni, M., Basu, A., Nair, K. S., Jensen, M. D., Khosla, S., Klee, G., Toffolo, G., Cobelli, C. & Rizza, R. A., Mar 2007, In : Diabetes. 56, 3, p. 753-766 14 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Insulin
Glucose
Placebos
Glucose Tolerance Test
2006
2 Citations (Scopus)

{A figure is presented} Long-term fracture risk among women with proven endometriosis

Melton, L. J., Leibson, C. L., Good, A. E., Achenbach, S. J., Oberg, A. L. & Khosla, S., Dec 2006, In : Fertility and Sterility. 86, 6, p. 1576-1583 8 p.

Research output: Contribution to journalArticle

Endometriosis
Confidence Intervals
Selective Estrogen Receptor Modulators
Tamoxifen
Forearm
111 Citations (Scopus)

Age- and sex-specific differences in the factor of risk for vertebral fracture: A population-based study using QCT

Bouxsein, M. L., Melton, L. J., Riggs, B. L., Muller, J., Atkinson, E. J., Oberg, A. L., Robb, R. A., Camp, J. J., Rouleau, P. A., McCollough, C. H. & Khosla, S., Sep 2006, In : Journal of Bone and Mineral Research. 21, 9, p. 1475-1482 8 p.

Research output: Contribution to journalArticle

Sex Characteristics
Population
Compressive Strength
Body Height
Body Weight
76 Citations (Scopus)

Bone fragility in men - Where are we?

Seeman, E., Bianchi, G., Khosla, S., Kanis, J. A. & Orwoll, E., Nov 2006, In : Osteoporosis International. 17, 11, p. 1577-1583 7 p.

Research output: Contribution to journalArticle

Bone and Bones
Epidemiology
Osteoporosis
Bone Density
Hip Fractures
83 Citations (Scopus)

Bone turnover across the menopause transition: Correlations with inhibins and follicle-stimulating hormone

Perrien, D. S., Achenbach, S. J., Bledsoe, S. E., Walser, B., Suva, L. J., Khosla, S. & Gaddy, D., May 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 5, p. 1848-1854 7 p.

Research output: Contribution to journalArticle

Inhibins
Bone Remodeling
Follicle Stimulating Hormone
Menopause
Bone
69 Citations (Scopus)

Circulating cells with osteogenic potential

Khosla, S. & Eghbali-Fatourechi, G. Z., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 489-497 9 p.

Research output: Contribution to journalArticle

Bone
Blood
Osteoblasts
Plastics
Flow cytometry
241 Citations (Scopus)

Clinical practice guideline: Androgen therapy in women: An Endocrine Society clinical practice guideline

Wierman, M. E., Basson, R., Davis, S. R., Khosla, S., Miller, K. K., Rosner, W. & Santoro, N., Oct 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 10, p. 3697-3710 14 p.

Research output: Contribution to journalArticle

Practice Guidelines
Androgens
Advisory Committees
Testosterone
Guidelines
417 Citations (Scopus)

DHEA in elderly women and DHEA or testosterone in elderly men

Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., Cobelli, C., Toffolo, G., Man, C. D., Tindall, D. J., Melton, L. J., Smith, G. E., Khosla, S. & Jensen, M. D., Oct 19 2006, In : New England Journal of Medicine. 355, 16, p. 1647-1659 13 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Testosterone
Placebos
Body Composition
Bone Density
38 Citations (Scopus)

Does reduced skeletal loading account for age-related bone loss?

Melton, L. J., Riggs, B. L., Achenbach, S. J., Amin, S., Camp, J. J., Rouleau, P. A., Robb, R. A., Oberg, A. L. & Khosla, S., Dec 2006, In : Journal of Bone and Mineral Research. 21, 12, p. 1847-1855 9 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone and Bones
Femur Neck
Skeletal Muscle
Exercise
Teriparatide
Hormone Replacement Therapy
Bone Density
34 Citations (Scopus)
Sex Hormone-Binding Globulin
Steroids
381 Citations (Scopus)

Effects of sex and age on bone microstructure at the ultradistal radius: A population-based noninvasive in vivo assessment

Khosla, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., McDaniel, L. J., Holets, M., Peterson, J. M. & Melton, L. J., Jan 2006, In : Journal of Bone and Mineral Research. 21, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

Bone and Bones
Population
Wrist
Immunity
Three-Dimensional Imaging
1 Citation (Scopus)

Estrogen receptor beta: the antimechanostat?

Khosla, S., Modder, U. I., Moedder, U. I. & Syed, F. A., Feb 1 2006, In : Bone. 38, 2

Research output: Contribution to journalArticle

Cellular Mechanotransduction
Estrogen Receptor beta
Periosteum
Estrogen Receptor alpha
Osteogenesis
19 Citations (Scopus)

Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: Roles of AF1 and enhancer elements

Monroe, D. G., Secreto, F. J., Hawse, J. R., Subramaniam, M., Khosla, S. & Spelsberg, T. C., Sep 29 2006, In : Journal of Biological Chemistry. 281, 39, p. 28596-28604 9 p.

Research output: Contribution to journalArticle

Retinoblastoma-Binding Protein 1
Estrogen Receptors
Transcriptional Activation
Protein Isoforms
Genes
81 Citations (Scopus)

Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men

Khosla, S., Melton, L. J., Achenbach, S. J., Oberg, A. L. & Riggs, B. L., Mar 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 3, p. 885-891 7 p.

Research output: Contribution to journalArticle

Bone
Microstructure
Bone Remodeling
Insulin-Like Growth Factor I
Bone and Bones
246 Citations (Scopus)

Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993-2001: An update on the changing epidemiology of the disease

Wermers, R. A., Khosla, S., Atkinson, E. J., Achenbach, S. J., Oberg, A. L., Grant, C. S. & Melton, L. J., Jan 2006, In : Journal of Bone and Mineral Research. 21, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

Primary Hyperparathyroidism
Epidemiology
Incidence
Parathyroidectomy
Calcium
2 Citations (Scopus)

Letter to the editor [2]

Khosla, S., Moedder, U. I. & Syed, F. A., Feb 2006, In : Bone. 38, 2, p. 289 1 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., Oberg, A. L., Rouleau, P. A., McCollough, C. H., Khosla, S. & Bouxsein, M. L., Feb 2006, In : Journal of Bone and Mineral Research. 21, 2, p. 315-323 9 p.

Research output: Contribution to journalArticle

Hip Fractures
Wrist
Bone and Bones
Femur Neck
Population
2 Citations (Scopus)

Sex Steroid Effects on Bone Metabolism

Monroe, D. G., Spelsberg, T. C. & Khosla, S., 2006, Dynamics of Bone and Cartilage Metabolism. Elsevier Inc., p. 327-343 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Steroids
Bone and Bones
Estrogens
Androgens
Skeleton
15 Citations (Scopus)

Systemic assessments utilizing saliva: Part 2 - Osteoporosis and use of saliva to measure bone turnover

Koka, S., Forde, M. D. & Khosla, S., Jan 2006, In : International Journal of Prosthodontics. 19, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

Bone Remodeling
Saliva
Osteoporosis
1 Citation (Scopus)

The classical estrogen receptor transcriptional pathway: Implications in human osteoblasts

Monroe, D. G., Secreto, F. J., Khosla, S. & Spelsberg, T. C., 2006, In : Clinical Reviews in Bone and Mineral Metabolism. 4, 2, p. 129-140 12 p.

Research output: Contribution to journalArticle

Osteoblasts
Estrogen Receptors
Protein Isoforms
Selective Estrogen Receptor Modulators
Osteoclasts
2005
6 Citations (Scopus)
Bone Remodeling
Insulin-Like Growth Factor I
Gonadotropin-Releasing Hormone
Estradiol
Bone
10 Citations (Scopus)

Bone marrow stromal cells express two distinct splice variants of ER-α that are regulated by estrogen

Sanyal, A., Riggs, B. L., Spelsberg, T. C. & Khosla, S., Jan 1 2005, In : Journal of Cellular Biochemistry. 94, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Estrogen Receptors
Bone
Estrogens
Exons
17 Citations (Scopus)

Circulating osteoblast-lineage cells [4] (multiple letters)

Sata, M., Tanaka, K., Nagai, R., Eghbali-Fatourechi, G. Z. & Khosla, S., Aug 18 2005, In : New England Journal of Medicine. 353, 7, p. 737-738 2 p.

Research output: Contribution to journalArticle

Calcinosis
Bone Remodeling
Cell Lineage
Stromal Cells
Osteoblasts
286 Citations (Scopus)

Circulating osteoblast-lineage cells in humans

Eghbali-Fatourechi, G. Z., Lamsam, J., Fraser, D., Nagel, D., Riggs, B. L. & Khosla, S., May 12 2005, In : New England Journal of Medicine. 352, 19, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

Osteoblasts
Osteogenesis
Osteocalcin
Bone and Bones
Growth
87 Citations (Scopus)
Bone Density
Odds Ratio
Confidence Intervals
Femur Neck
Pelvic Bones
108 Citations (Scopus)

Estrogen receptor α and β heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2Os osteosarcoma cells

Monroe, D. G., Secreto, F. J., Subramaniam, M., Getz, B. J., Khosla, S. & Spelsberg, T. C., Jun 2005, In : Molecular Endocrinology. 19, 6, p. 1555-1568 14 p.

Research output: Contribution to journalArticle

Osteosarcoma
Tamoxifen
Estrogen Receptors
Estrogens
Gene Expression
25 Citations (Scopus)

Evaluation of a prediction model for long-term fracture risk

Melton, L. J., Atkinson, E. J., Khosla, S., Oberg, A. L. & Lawrence Riggs, B., Apr 2005, In : Journal of Bone and Mineral Research. 20, 4, p. 551-556 6 p.

Research output: Contribution to journalArticle

Osteoporosis
Femur Neck
Incidence
Aptitude
Statistical Models
4 Citations (Scopus)

Magic bullets to kill nasty osteoclasts

Khosla, S., Aug 2005, In : Endocrinology. 146, 8, p. 3233-3234 2 p.

Research output: Contribution to journalArticle

Receptor Activator of Nuclear Factor-kappa B
RANK Ligand
Osteoprotegerin
Biological Models
Magic
273 Citations (Scopus)

Mechanisms of sex steroid effects on bone

Syed, F. & Khosla, S., Mar 18 2005, In : Biochemical and Biophysical Research Communications. 328, 3, p. 688-696 9 p.

Research output: Contribution to journalArticle

Bone
Bone Remodeling
Steroids
Bone and Bones
Osteoblasts
33 Citations (Scopus)

Osteoporosis assessment by whole body region vs. site-specific DXA

Melton, L. J., Looker, A. C., Shepherd, J. A., O'Connor, M. K., Achenbach, S. J., Riggs, B. L. & Khosla, S., Dec 2005, In : Osteoporosis International. 16, 12, p. 1558-1564 7 p.

Research output: Contribution to journalArticle

Body Regions
Osteoporosis
Spine
Whole Body Imaging
Femur Neck
177 Citations (Scopus)

Pathophysiology of age-related bone loss and osteoporosis

Khosla, S. & Riggs, B. L., Dec 2005, In : Endocrinology and Metabolism Clinics of North America. 34, 4, p. 1015-1030 16 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone
Bone and Bones
Sarcopenia
Secondary Hyperparathyroidism
67 Citations (Scopus)

Potential role of pancreatic and enteric hormones in regulating bone turnover

Clowes, J. A., Khosla, S. & Eastell, R., Sep 2005, In : Journal of Bone and Mineral Research. 20, 9, p. 1497-1506 10 p.

Research output: Contribution to journalArticle

Pancreatic Hormones
Gastrointestinal Hormones
Bone Remodeling
Bone and Bones
Food