• 38865 Citations
  • 100 Scopus h-Index
1976 …2021
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Research Output 1980 2019

2 Citations (Scopus)

{A figure is presented} Long-term fracture risk among women with proven endometriosis

Melton, L. J., Leibson, C. L., Good, A. E., Achenbach, S. J., Oberg, A. L. & Khosla, S., Dec 2006, In : Fertility and Sterility. 86, 6, p. 1576-1583 8 p.

Research output: Contribution to journalArticle

Endometriosis
Confidence Intervals
Selective Estrogen Receptor Modulators
Tamoxifen
Forearm
32 Citations (Scopus)

Abdominal aortic calcification, BMD, and bone microstructure: A population-based study

Chow, J. T., Khosla, S., Melton, L. J., Atkinson, E. J., Camp, J. J. & Kearns, A. E., Oct 2008, In : Journal of Bone and Mineral Research. 23, 10, p. 1601-1612 12 p.

Research output: Contribution to journalArticle

Social Adjustment
Bone and Bones
Population
Vascular Calcification
Femur Neck
2 Citations (Scopus)

Ability of circulating human hematopoietic lineage negative cells to support hematopoiesis

Peris, P., Roforth, M. M., Nicks, K. M., Fraser, D., Fujita, K., Jilka, R. L., Khosla, S. & McGregor, U., Jan 1 2015, In : Journal of Cellular Biochemistry. 116, 1, p. 58-66 9 p.

Research output: Contribution to journalArticle

Thymidine Kinase
Hematopoiesis
Ganciclovir
Osteoblasts
Bone
71 Citations (Scopus)

Abnormalities of parathyroid hormone secretion in elderly women that are reversible by short term therapy with 1,25-dihydroxyvitamin D3

Ledger, G. A., Burritt, M. F., Kao, P. C., O'Fallon, W. M., Riggs, B. L. & Khosla, S., Jul 1994, In : Journal of Clinical Endocrinology and Metabolism. 79, 1, p. 211-216 6 p.

Research output: Contribution to journalArticle

Calcitriol
Parathyroid Hormone
Aging of materials
Edetic Acid
Bone
107 Citations (Scopus)

A bone structural basis for fracture risk in diabetes

Melton, L. J., Riggs, B. L., Leibson, C. L., Achenbach, S. J., Camp, J. J., Bouxsein, M. L., Atkinson, E. J., Robb, R. A. & Khosla, S., Dec 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 12, p. 4804-4809 6 p.

Research output: Contribution to journalArticle

Medical problems
Bone
Bone and Bones
Bone Density
Pelvic Bones
110 Citations (Scopus)

A Crisis in the Treatment of Osteoporosis

Khosla, S. & Shane, E., Aug 1 2016, In : Journal of Bone and Mineral Research. 31, 8, p. 1485-1487 3 p.

Research output: Contribution to journalEditorial

Osteoporosis

ACTH and indomethacin-induced antidiuresis in low salt Brattleboro strain rats: Induction and escape

Khosla, S., Kinter, L. B., Zusman, R. & Beeuwkes, R., 1982, In : Annals of the New York Academy of Sciences. Vol. 394, p. 265-269 5 p.

Research output: Contribution to journalArticle

Brattleboro Rats
Vasopressins
Indomethacin
Adrenocorticotropic Hormone
Rats
53 Citations (Scopus)

Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward

Khosla, S., Cauley, J. A., Compston, J., Kiel, D. P., Rosen, C., Saag, K. G. & Shane, E., Mar 1 2017, In : Journal of Bone and Mineral Research. 32, 3, p. 424-430 7 p.

Research output: Contribution to journalArticle

Osteoporosis
Femur
Photon Absorptiometry
Therapeutics
Bone Density Conservation Agents
29 Citations (Scopus)

A defect in renal calcium conservation may contribute to the pathogenesis of postmenopausal osteoporosis

Heshmati, H. M., Khosla, S., Burritt, M. F., O'fallon, W. M. & Riggs, B. L., 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 6, p. 1916-1920 5 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Conservation
Calcium
Kidney
Defects
24 Citations (Scopus)

A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women

Amin, S., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Dekutoski, M. B., Kirmani, S., Fischer, P. R. & Khosla, S., 2013, In : Journal of Bone and Mineral Research. 28, 8, p. 1751-1759 9 p.

Research output: Contribution to journalArticle

Forearm
Incidence
Medical Record Linkage
Bone and Bones
Wrist
11 Citations (Scopus)

A DNA binding mutation in estrogen receptor-α Leads to suppression of Wnt signaling via β-catenin destabilization in osteoblasts

Mödder, U. I., Rudnik, V., Liu, G., Khosla, S. & Monroe, D. G., Jul 2012, In : Journal of Cellular Biochemistry. 113, 7, p. 2248-2255 8 p.

Research output: Contribution to journalArticle

Catenins
Osteoblasts
Estrogen Receptors
Mutation
DNA
17 Citations (Scopus)

Adrenal crisis in the setting of high-dose ketoconazole therapy

Khosla, S., Wolfson, J. S., Demerjian, Z. & Godine, J. E., 1989, In : Archives of Internal Medicine. 149, 4, p. 802-804 3 p.

Research output: Contribution to journalArticle

Ketoconazole
Adrenal Insufficiency
Hypothyroidism
Acanthamoeba Keratitis
Therapeutics

Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel

Sampson, U. K. A., McGlynn, E. A., Perlin, J. B., Frisse, M. E., Arnold, S. B., Benz, E. J., Brennan, T., Briss, P., Beeuwkes Buntin, M. J., Khosla, S., King, R. G., Kuntz, R., Leider, H., Ling, S. M., Macrae, J., Murray, R., Thrailkill, E., Wager, C., Witchey, D. & Jacobson, H. R., Jan 1 2018, (Accepted/In press) In : Global Heart.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Delivery of Health Care
Health Services
Public-Private Sector Partnerships
Government Agencies
15 Citations (Scopus)

A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors

Nagel, D. E., Khosla, S., Sanyal, A., Rosen, D. M., Kumagai, Y. & Riggs, B. L., 2004, In : Journal of Cellular Biochemistry. 93, 6, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

Anabolic Agents
Osteocalcin
Osteoblasts
Cyclooxygenase 2
Gene expression
111 Citations (Scopus)

Age- and sex-specific differences in the factor of risk for vertebral fracture: A population-based study using QCT

Bouxsein, M. L., Melton, L. J., Riggs, B. L., Muller, J., Atkinson, E. J., Oberg, A. L., Robb, R. A., Camp, J. J., Rouleau, P. A., McCollough, C. H. & Khosla, S., Sep 2006, In : Journal of Bone and Mineral Research. 21, 9, p. 1475-1482 8 p.

Research output: Contribution to journalArticle

Sex Characteristics
Population
Compressive Strength
Body Height
Body Weight
106 Citations (Scopus)

Age-dependence of femoral strength in white women and men

Keaveny, T. M., Kopperdahl, D. L., Melton, L. J., Hoffmann, P. F., Amin, S., Riggs, B. L. & Khosla, S., May 2010, In : Journal of Bone and Mineral Research. 25, 5, p. 994-1001 8 p.

Research output: Contribution to journalArticle

Thigh
Bone Density
Femur Neck
Osteoporosis
Bone and Bones
20 Citations (Scopus)

Age-dependent renal cortical microvascular loss in female mice

Urbieta-Caceres, V. H., Syed, F. A., Lin, J., Zhu, X. Y., Jordan, K. L., Bell, C. C., Bentley, M. D., Lerman, A., Khosla, S. & Lerman, L. O., Apr 15 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 8

Research output: Contribution to journalArticle

Kidney
Estrogens
Microvessels
Oxidative Stress
Angiogenesis Inducing Agents
4 Citations (Scopus)

Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study

Lee, T. H., Setty, P. T., Parthasarathy, G., Bailey, K. R., Wood-Wentz, C. M., Fletcher, J. G., Takahashi, N. M., Khosla, S., Moynagh, M. R., Zinsmeister, A. R. & Bharucha, A. E., Sep 1 2018, In : Mayo Clinic Proceedings. 93, 9, p. 1256-1265 10 p.

Research output: Contribution to journalArticle

Diverticulitis
Obesity
Incidence
Body Mass Index
Population
Osteoporotic Fractures
National Institutes of Health (U.S.)
Osteoporosis
Drug Therapy
Research
114 Citations (Scopus)

Androgen effects on bone metabolism: Recent progress and controversies

Hofbauer, L. C. & Khosla, S., Apr 1999, In : European Journal of Endocrinology. 140, 4, p. 271-286 16 p.

Research output: Contribution to journalArticle

Androgens
Bone and Bones
Androgen Receptors
Androgen Receptor Antagonists
Insulin-Like Growth Factor Binding Proteins
11 Citations (Scopus)

Androgens, estrogens, and bone turnover in men (multiple letters)

Khosla, S., Riggs, B. L., Leder, B. Z. & Finkelstein, J. S., May 1 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 5, p. 2352-2353 2 p.

Research output: Contribution to journalArticle

Bone Remodeling
Androgens
Bone
Estrogens
112 Citations (Scopus)

Androgens and bone

Clarke, B. & Khosla, S., Mar 2009, In : Steroids. 74, 3, p. 296-305 10 p.

Research output: Contribution to journalArticle

Androgens
Testosterone
Bone
Bone and Bones
Estradiol
322 Citations (Scopus)

A population-based assessment of rates of bone loss at multiple skeletal sites: Evidence for substantial trabecular bone loss in young adult women and men

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., McDaniel, L., Amin, S., Rouleau, P. A. & Khosla, S., Feb 2008, In : Journal of Bone and Mineral Research. 23, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

Young Adult
Bone and Bones
Population
Tibia
Perimenopause
60 Citations (Scopus)

A potentially deleterious role of IGFBP-2 on bone density in aging men and women

Amin, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Melton, L. J. & Khosla, S., Jul 2004, In : Journal of Bone and Mineral Research. 19, 7, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Bone Density
Insulin-Like Growth Factor Binding Proteins
Somatomedins
Insulin-Like Growth Factor I
37 Citations (Scopus)

Applications of a new handheld reference point indentation instrument measuring bone material strength

Randall, C., Bridges, D., Guerri, R., Nogues, X., Puig, L., Torres, E., Mellibovsky, L., Hoffseth, K., Stalbaum, T., Srikanth, A., Weaver, J. C., Rosen, S., Barnard, H., Brimer, D., Proctor, A., Candy, J., Saldana, C., Chandrasekar, S., Lescun, T., Nielson, C. M. & 9 others, Orwoll, E., Herthel, D., Kopeikin, H., Yang, H. T. Y., Farr, J., McCready, L., Khosla, S., Diez-Perez, A. & Hansma, P. K., Sep 24 2013, In : Journal of Medical Devices, Transactions of the ASME. 7, 4, 041005.

Research output: Contribution to journalArticle

Indentation
Bone
Bone and Bones
Horses
Clinical Trials
3 Citations (Scopus)

A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy

ASPREE Investigator Group, May 21 2015, (Accepted/In press) In : Injury Prevention.

Research output: Contribution to journalArticle

Aspirin
Randomized Controlled Trials
Placebos
Hip Fractures
Primary Prevention
6 Citations (Scopus)
Bone Remodeling
Insulin-Like Growth Factor I
Gonadotropin-Releasing Hormone
Estradiol
Bone
6 Citations (Scopus)

Are the endocrine society's clinical practice guidelines on androgen therapy in women misguided? A commentary-response

Wierman, M., Basson, R., Davis, S., Khosla, S., Miller, K., Rosner, W. & Santoro, N., Nov 2007, In : Journal of Sexual Medicine. 4, 6, p. 1782-1783 2 p.

Research output: Contribution to journalArticle

Practice Guidelines
Androgens
Therapeutics
25 Citations (Scopus)

Aromatase inhibitor-associated bone fractures: A case-cohort GWAS and functional genomics

Liu, M., Goss, P. E., Ingle, J. N., Kubo, M., Furukawa, Y., Batzler, A., Jenkins, G. D., Carlson, E. E., Nakamura, Y., Schaid, D. J., Chapman, J. A. W., Shepherd, L. E., Ellis, M. J., Khosla, S., Wang, L. M. & Weinshilboum, R. M., Oct 1 2014, In : Molecular Endocrinology. 28, 10, p. 1740-1751 12 p.

Research output: Contribution to journalArticle

Aromatase Inhibitors
Genome-Wide Association Study
Bone Fractures
Genomics
Single Nucleotide Polymorphism
83 Citations (Scopus)

Assessing forearm fracture risk in postmenopausal women

Melton, L. J., Christen, D., Riggs, B. L., Achenbach, S. J., Müller, R., Van Lenthe, G. H., Amin, S., Atkinson, E. J. & Khosla, S., Jul 2010, In : Osteoporosis International. 21, 7, p. 1161-1169 9 p.

Research output: Contribution to journalArticle

Forearm
Bone Density
Odds Ratio
Confidence Intervals
Femur Neck
25 Citations (Scopus)

Assessing fracture risk using gradient boosting machine (GBM) models

Atkinson, E. J., Therneau, T. M., Melton, L. J., Camp, J. J., Achenbach, S. J., Amin, S. & Khosla, S., Jun 2012, In : Journal of Bone and Mineral Research. 27, 6, p. 1397-1404 8 p.

Research output: Contribution to journalArticle

Area Under Curve
Forearm
Bone Density
Tomography
Bone and Bones
1 Citation (Scopus)

Assessing the true impact of recurrent fractures on fracture risk

Clarke, B. & Khosla, S., 2009, In : Journal of Bone and Mineral Research. 24, 9, p. 1512-1514 3 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Bone Fractures
Photon Absorptiometry
Bone Density
Recurrence
71 Citations (Scopus)

Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology

Locklin, R. M., Riggs, B. L., Hicok, K. C., Horton, H. F., Byrne, M. C. & Khosla, S., 2001, In : Journal of Bone and Mineral Research. 16, 12, p. 2192-2204 13 p.

Research output: Contribution to journalArticle

Stromal Cells
Bone Marrow
Bone Morphogenetic Protein 2
Technology
Genes
68 Citations (Scopus)

Association of hip strength estimates by finite-element analysis with fractures in women and men

Amin, S., Kopperdhal, D. L., Melton, L. J., Achenbach, S. J., Therneau, T. M., Riggs, B. L., Keaveny, T. M. & Khosla, S., Jul 2011, In : Journal of Bone and Mineral Research. 26, 7, p. 1593-1600 8 p.

Research output: Contribution to journalArticle

Finite Element Analysis
Hip
Osteoporotic Fractures
Tomography
Femur
27 Citations (Scopus)

A system for the analysis of whole-bone strength from helical CT images

Camp, J. J., Karwoski, R. A., Stacy, M. C., Atkinson, E. J., Khosla, S., Melton, L. J., Riggs, B. L. & Robb, R. A., 2004, Proceedings of SPIE - The International Society for Optical Engineering. Amini, A. A. & Mandura, A. (eds.). Vol. 5369. p. 74-88 15 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

bones
Bone
osteoporosis
Minerals
minerals
832 Citations (Scopus)
Postmenopausal Osteoporosis
Osteoporosis
Estrogens
Bone and Bones
Calcium
6 Citations (Scopus)

Autoimmune hemolytic anemia with both cold and warm autoantibodies.

Nusbaum, N. J. & Khosla, S., Sep 6 1985, In : Journal of the American Medical Association. 254, 9, p. 1175-1176 2 p.

Research output: Contribution to journalArticle

Autoimmune Hemolytic Anemia
Agglutinins
Autoantibodies
Temperature
144 Citations (Scopus)

Benefits and risks of bisphosphonate therapy for osteoporosis

Khosla, S., Bilezikian, J. P., Dempster, D. W., Lewiecki, E. M., Miller, P. D., Neer, R. M., Recker, R. R., Shane, E., Shoback, D. & Potts, J. T., Jul 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 7, p. 2272-2282 11 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoporosis
Osteonecrosis
Jaw
Femur

Benefits and risks of bisphosphonate therapy for osteoporosis: Editorial comment

Khosla, S., Bilezikian, J. P., Dempster, D. W., Lewiecki, E. M., Miller, P. D., Neer, R. M., Recker, R. R., Shane, E., Shoback, D. & Potts, J. T., Jan 2013, In : Obstetrical and Gynecological Survey. 68, 1, p. 37-39 3 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoporosis
Therapeutics
52 Citations (Scopus)

Beta-lactamase inactivation by mechanism-based reagents.

Fisher, J., Belasco, J. G., Charnas, R. L., Khosla, S. & Knowles, J. R., May 16 1980, In : Philosophical transactions of the Royal Society of London. Series B: Biological sciences. 289, 1036, p. 309-319 11 p.

Research output: Contribution to journalArticle

beta-lactamase
beta-Lactamases
inactivation
enzyme
Sulfones
10 Citations (Scopus)

Better tools for assessing osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., Dec 3 2012, In : Journal of Clinical Investigation. 122, 12, p. 4323-4324 2 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone Fractures
Photon Absorptiometry
Skeleton
Spine
122 Citations (Scopus)

Bisphosphonate associated osteonecrosis of the jaw

Khan, A. A., Sándor, G. K. B., Dore, E., Morrison, A. D., Alsahli, M., Amin, F., Peters, E., Hanley, D. A., Chaudry, S. R., Lentle, B., Dempster, D. W., Glorieux, F. H., Neville, A. J., Talwar, R. M., Clokie, C. M., Al Mardini, M., Paul, T., Khosla, S., Josse, R. G., Sutherland, S. & 10 others, Lam, D. K., Carmichael, R. P., Blanas, N., Kendler, D., Petak, S., Ste-Marie, L. G., Brown, J., Evans, A. W., Rios, L. & Compston, J. E., Mar 2009, In : Journal of Rheumatology. 36, 3, p. 478-490 13 p.

Research output: Contribution to journalArticle

Bisphosphonate-Associated Osteonecrosis of the Jaw
Diphosphonates
Jaw
Osteoporosis
Osteonecrosis
1162 Citations (Scopus)

Bisphosphonate-associated osteonecrosis of the jaw: Report of a Task Force of the American Society for Bone and Mineral Research

Khosla, S., Burr, D., Cauley, J., Dempster, D. W., Ebeling, P. R., Felsenberg, D., Gagel, R. F., Gilsanz, V., Guise, T., Koka, S., McCauley, L. K., McGowan, J., McKee, M. D., Mohla, S., Pendrys, D. G., Raisz, L. G., Ruggiero, S. L., Shafer, D. M., Shum, L., Silverman, S. L. & 4 others, Van Poznak, C. H., Watts, N., Woo, S. B. & Shane, E., Oct 2007, In : Journal of Bone and Mineral Research. 22, 10, p. 1479-1491 13 p.

Research output: Contribution to journalArticle

Bisphosphonate-Associated Osteonecrosis of the Jaw
Osteonecrosis
Advisory Committees
Jaw
Diphosphonates
600 Citations (Scopus)

Bisphosphonates: Mechanism of action and role in clinical practice

Drake, M. M., Clarke, B. & Khosla, S., 2008, In : Mayo Clinic Proceedings. 83, 9, p. 1032-1045 14 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoclasts
Osteitis Deformans
Bone and Bones
Osteogenesis Imperfecta
5 Citations (Scopus)

Bisphosphonates and the upper gastrointestinal tract: Skeletal gain without visceral pain?

Tremaine, W. J. & Khosla, S., Oct 1 2002, In : Mayo Clinic Proceedings. 77, 10, p. 1029-1030 2 p.

Research output: Contribution to journalArticle

Visceral Pain
Upper Gastrointestinal Tract
Diphosphonates
20 Citations (Scopus)

Body composition during childhood and adolescence: Relations to bone strength and microstructure

Farr, J., Amin, S., LeBrasseur, N. K., Atkinson, E. J., Achenbach, S. J., McCready, L. K., Melton, L. J. & Khosla, S., Dec 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 12, p. 4641-4648 8 p.

Research output: Contribution to journalArticle

Body Composition
Bone
Bone and Bones
Microstructure
Fats
69 Citations (Scopus)

Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: A nested substudy of the MAP.3 randomised controlled trial

Cheung, A. M., Tile, L., Cardew, S., Pruthi, S., Robbins, J., Tomlinson, G., Kapral, M. K., Khosla, S., Majumdar, S., Erlandson, M., Scher, J., Hu, H., Demaras, A., Lickley, L., Bordeleau, L., Elser, C., Ingle, J., Richardson, H. & Goss, P. E., Mar 2012, In : The Lancet Oncology. 13, 3, p. 275-284 10 p.

Research output: Contribution to journalArticle

exemestane
Primary Prevention
Bone Density
Randomized Controlled Trials
Breast Neoplasms
10 Citations (Scopus)

Bone diseases: Romosozumab-on track or derailed?

Khosla, S., Dec 1 2017, In : Nature Reviews Endocrinology. 13, 12, p. 697-698 2 p.

Research output: Contribution to journalShort survey

Bone Diseases
AMG 785
76 Citations (Scopus)

Bone fragility in men - Where are we?

Seeman, E., Bianchi, G., Khosla, S., Kanis, J. A. & Orwoll, E., Nov 2006, In : Osteoporosis International. 17, 11, p. 1577-1583 7 p.

Research output: Contribution to journalArticle

Bone and Bones
Epidemiology
Osteoporosis
Bone Density
Hip Fractures
24 Citations (Scopus)

Bone growth and turnover in progesterone receptor knockout mice

Rickard, D. J., Iwaniec, U. T., Evans, G., Hefferan, T. E., Hunter, J. C., Waters, K. M., Lydon, J. P., O'Malley, B. W., Khosla, S., Spelsberg, T. C. & Turner, R. T., May 2008, In : Endocrinology. 149, 5, p. 2383-2390 8 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone Development
Progesterone Receptors
Knockout Mice
Tibia