• 38820 Citations
  • 100 Scopus h-Index
1976 …2021
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Research Output 1980 2019

2013
24 Citations (Scopus)

A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women

Amin, S., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Dekutoski, M. B., Kirmani, S., Fischer, P. R. & Khosla, S., 2013, In : Journal of Bone and Mineral Research. 28, 8, p. 1751-1759 9 p.

Research output: Contribution to journalArticle

Forearm
Incidence
Medical Record Linkage
Bone and Bones
Wrist
37 Citations (Scopus)

Applications of a new handheld reference point indentation instrument measuring bone material strength

Randall, C., Bridges, D., Guerri, R., Nogues, X., Puig, L., Torres, E., Mellibovsky, L., Hoffseth, K., Stalbaum, T., Srikanth, A., Weaver, J. C., Rosen, S., Barnard, H., Brimer, D., Proctor, A., Candy, J., Saldana, C., Chandrasekar, S., Lescun, T., Nielson, C. M. & 9 others, Orwoll, E., Herthel, D., Kopeikin, H., Yang, H. T. Y., Farr, J., McCready, L., Khosla, S., Diez-Perez, A. & Hansma, P. K., Sep 24 2013, In : Journal of Medical Devices, Transactions of the ASME. 7, 4, 041005.

Research output: Contribution to journalArticle

Indentation
Bone
Bone and Bones
Horses
Clinical Trials

Benefits and risks of bisphosphonate therapy for osteoporosis: Editorial comment

Khosla, S., Bilezikian, J. P., Dempster, D. W., Lewiecki, E. M., Miller, P. D., Neer, R. M., Recker, R. R., Shane, E., Shoback, D. & Potts, J. T., Jan 2013, In : Obstetrical and Gynecological Survey. 68, 1, p. 37-39 3 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoporosis
Therapeutics
45 Citations (Scopus)

Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes

Klingberg, E., Lorentzon, M., Göthlin, J., Mellström, D., Geijer, M., Ohlsson, C., Atkinson, E. J., Khosla, S., Carlsten, H. & Forsblad-d'Elia, H., Nov 5 2013, In : Arthritis Research and Therapy. 15, 6, R179.

Research output: Contribution to journalArticle

Ankylosing Spondylitis
Bone Density
Bone and Bones
Tibia
Spine
23 Citations (Scopus)

Effects of bisphosphonate treatment on circulating osteogenic endothelial progenitor cells in postmenopausal women

Peris, P., Atkinson, E. J., Gössl, M., Kane, T. L., McCready, L. K., Lerman, A., Khosla, S. & McGregor, U. I., Jan 2013, In : Mayo Clinic Proceedings. 88, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

Diphosphonates
Vascular Calcification
Osteocalcin
Osteoblasts
Down-Regulation
24 Citations (Scopus)
Progesterone
Bone
Estrogens
Hormones
Microstructure
10 Citations (Scopus)

Estrogen Deficiency, Postmenopausal Osteoporosis, and Age-Related Bone Loss

Khosla, S. & Pacifici, R., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1113-1136 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Postmenopausal Osteoporosis
Osteoporosis
Estrogens
T-Lymphocytes
RANK Ligand
8 Citations (Scopus)

Identification of Rorβ targets in cultured osteoblasts and in human bone

Roforth, M. M., Khosla, S. & Monroe, D. G., Nov 1 2013, In : Biochemical and Biophysical Research Communications. 440, 4, p. 768-773 6 p.

Research output: Contribution to journalArticle

Osteoblasts
Bone
Genes
Bone and Bones
Extracellular Matrix
27 Citations (Scopus)

Improved fracture risk assessment based on nonlinear micro-finite element simulations from HRpQCT images at the distal radius

Christen, D., Melton, L. J., Zwahlen, A., Amin, S., Khosla, S. & Müller, R., Dec 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2601-2608 8 p.

Research output: Contribution to journalArticle

Odds Ratio
Tomography
Confidence Intervals
Bone and Bones
Forearm
8 Citations (Scopus)

Longitudinal changes in lumbar bone mineral density distribution may increase the risk of wedge fractures

Giambini, H., Khosla, S., Nassr, A., Zhao, C. D. & An, K. N., Jan 2013, In : Clinical Biomechanics. 28, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

Bone Density
Spine
Body Regions
Individuality
Osteoporosis
67 Citations (Scopus)

Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography

Burghardt, A. J., Pialat, J. B., Kazakia, G. J., Boutroy, S., Engelke, K., Patsch, J. M., Valentinitsch, A., Liu, D., Szabo, E., Bogado, C. E., Zanchetta, M. B., McKay, H. A., Shane, E., Boyd, S. K., Bouxsein, M. L., Chapurlat, R., Khosla, S. & Majumdar, S., Mar 2013, In : Journal of Bone and Mineral Research. 28, 3, p. 524-536 13 p.

Research output: Contribution to journalArticle

Porosity
Tomography
Imaging Phantoms
Finite Element Analysis
Bone Density
1 Citation (Scopus)

Osteonecrosis of the Jaw and Atypical Femoral Fractures

Shane, E., Khosla, S. & Burr, D., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1873-1908 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Femoral Fractures
Osteonecrosis
Diphosphonates
Jaw
Osteoporosis
95 Citations (Scopus)

Pathogenesis of age-related bone loss in humans

Khosla, S., Oct 2013, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 68, 10, p. 1226-1235 10 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone and Bones
Estrogens
Rodentia
Interleukin-1
35 Citations (Scopus)

Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells

Flammer, A. J., Martin, E. A., Gössl, M., Widmer, R. J., Lennon, R. J., Sexton, J. A., Loeffler, D., Khosla, S., Lerman, L. O. & Lerman, A., Feb 2013, In : European Journal of Nutrition. 52, 1, p. 289-296 8 p.

Research output: Contribution to journalArticle

Vaccinium macrocarpon
Osteocalcin
Polyphenols
Blood Vessels
Placebos
47 Citations (Scopus)

Proximal femoral density distribution and structure in relation to age and hip fracture risk in women

Carballido-Gamio, J., Harnish, R., Saeed, I., Streeper, T., Sigurdsson, S., Amin, S., Atkinson, E. J., Therneau, T. M., Siggeirsdottir, K., Cheng, X., Melton, L. J., Keyak, J., Gudnason, V., Khosla, S., Harris, T. B. & Lang, T. F., Mar 2013, In : Journal of Bone and Mineral Research. 28, 3, p. 537-546 10 p.

Research output: Contribution to journalArticle

Hip Fractures
Thigh
Hip
Atlases
Weight-Bearing
40 Citations (Scopus)

Relationship of adiposity to bone volumetric density and microstructure in men and women across the adult lifespan

Ng, A. C., Melton, L. J., Atkinson, E. J., Achenbach, S. J., Holets, M. F., Peterson, J. M., Khosla, S. & Drake, M. M., 2013, In : Bone. 55, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

Adiposity
Bone Density
Femur Neck
Spine
Adipose Tissue
33 Citations (Scopus)

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Aug 2013, In : Journal of Cellular Biochemistry. 114, 8, p. 1901-1907 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone
Conditioned Culture Medium
Osteogenesis
Bone Marrow
38 Citations (Scopus)

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Osteogenesis
Cell Movement
Bone
Phosphotransferases
28 Citations (Scopus)

Structural patterns of the proximal femur in relation to age and hip fracture risk in women

Carballido-Gamio, J., Harnish, R., Saeed, I., Streeper, T., Sigurdsson, S., Amin, S., Atkinson, E. J., Therneau, T. M., Siggeirsdottir, K., Cheng, X., Melton, L. J., Keyak, J. H., Gudnason, V., Khosla, S., Harris, T. B. & Lang, T. F., Nov 2013, In : Bone. 57, 1, p. 290-299 10 p.

Research output: Contribution to journalArticle

Hip Fractures
Femur
Bone Density
Femur Neck
Bone and Bones
35 Citations (Scopus)

TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Oct 1 2013, In : Endocrinology. 154, 10, p. 3745-3752 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
Bone Morphogenetic Protein 6
Bone Remodeling
Mitogen-Activated Protein Kinase Kinases
4 Citations (Scopus)

The Role of Sex Steroids in the Pathogenesis of Osteoporosis

Drake, M. M. & Khosla, S., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 367-375 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteoporosis
Bone
Aging of materials
Steroids
Bone and Bones
27 Citations (Scopus)

Three-dimensional structural analysis of the proximal femur in an age-stratified sample of women

Nicks, K. M., Amin, S., Melton, L. J., Atkinson, E. J., McCready, L. K., Riggs, B. L., Engelke, K. & Khosla, S., 2013, In : Bone. 55, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

Bone Density
Femur
Femur Neck
Bone and Bones
Hip Fractures
36 Citations (Scopus)

Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

Ota, K., Quint, P., Weivoda, M., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Nov 2013, In : Bone. 57, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Osteoclasts
Osteoblasts
Transforming Growth Factor beta
Bone Resorption
2012
11 Citations (Scopus)

A DNA binding mutation in estrogen receptor-α Leads to suppression of Wnt signaling via β-catenin destabilization in osteoblasts

Mödder, U. I., Rudnik, V., Liu, G., Khosla, S. & Monroe, D. G., Jul 2012, In : Journal of Cellular Biochemistry. 113, 7, p. 2248-2255 8 p.

Research output: Contribution to journalArticle

Catenins
Osteoblasts
Estrogen Receptors
Mutation
DNA
20 Citations (Scopus)

Age-dependent renal cortical microvascular loss in female mice

Urbieta-Caceres, V. H., Syed, F. A., Lin, J., Zhu, X. Y., Jordan, K. L., Bell, C. C., Bentley, M. D., Lerman, A., Khosla, S. & Lerman, L. O., Apr 15 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 8

Research output: Contribution to journalArticle

Kidney
Estrogens
Microvessels
Oxidative Stress
Angiogenesis Inducing Agents
25 Citations (Scopus)

Assessing fracture risk using gradient boosting machine (GBM) models

Atkinson, E. J., Therneau, T. M., Melton, L. J., Camp, J. J., Achenbach, S. J., Amin, S. & Khosla, S., Jun 2012, In : Journal of Bone and Mineral Research. 27, 6, p. 1397-1404 8 p.

Research output: Contribution to journalArticle

Area Under Curve
Forearm
Bone Density
Tomography
Bone and Bones
144 Citations (Scopus)

Benefits and risks of bisphosphonate therapy for osteoporosis

Khosla, S., Bilezikian, J. P., Dempster, D. W., Lewiecki, E. M., Miller, P. D., Neer, R. M., Recker, R. R., Shane, E., Shoback, D. & Potts, J. T., Jul 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 7, p. 2272-2282 11 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoporosis
Osteonecrosis
Jaw
Femur
10 Citations (Scopus)

Better tools for assessing osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., Dec 3 2012, In : Journal of Clinical Investigation. 122, 12, p. 4323-4324 2 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone Fractures
Photon Absorptiometry
Skeleton
Spine
69 Citations (Scopus)

Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: A nested substudy of the MAP.3 randomised controlled trial

Cheung, A. M., Tile, L., Cardew, S., Pruthi, S., Robbins, J., Tomlinson, G., Kapral, M. K., Khosla, S., Majumdar, S., Erlandson, M., Scher, J., Hu, H., Demaras, A., Lickley, L., Bordeleau, L., Elser, C., Ingle, J., Richardson, H. & Goss, P. E., Mar 2012, In : The Lancet Oncology. 13, 3, p. 275-284 10 p.

Research output: Contribution to journalArticle

exemestane
Primary Prevention
Bone Density
Randomized Controlled Trials
Breast Neoplasms
35 Citations (Scopus)

Characterization of mesenchymal progenitor cells isolated from human bone marrow by negative selection

Mödder, U. I., Roforth, M. M., Nicks, K. M., Peterson, J. M., McCready, L. K., Monroe, D. G. & Khosla, S., Mar 2012, In : Bone. 50, 3, p. 804-810 7 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone Marrow
Osteoblasts
Population
Osteoporosis
55 Citations (Scopus)

Emerging role of circulating calcifying cells in the bone-vascular axis

Fadini, G. P., Rattazzi, M., Matsumoto, T., Asahara, T. & Khosla, S., Jun 5 2012, In : Circulation. 125, 22, p. 2772-2781 10 p.

Research output: Contribution to journalArticle

Vascular Calcification
Calcinosis
Myeloid Cells
Osteoporosis
Blood Vessels

Erratum: Role of circulating osteogenic progenitor cells in calcific aortic stenosis (Journal of the American College of Cardiology (2012) 60 (194553))

Gössl, M., Khosla, S., Zhang, X., Higano, N., Jordan, K. L., Loeffler, D., Sarano, M. E., Lennon, R. J., McGregor, U., Lerman, L. O. & Lerman, A., Dec 18 2012, In : Journal of the American College of Cardiology. 60, 24, p. 2606 1 p.

Research output: Contribution to journalArticle

Stem Cells
Calcification of Aortic Valve
215 Citations (Scopus)

Estrogen and the skeleton

Khosla, S., Oursler, M. J. & Monroe, D. G., Nov 2012, In : Trends in Endocrinology and Metabolism. 23, 11, p. 576-581 6 p.

Research output: Contribution to journalArticle

Skeleton
Estrogens
Bone Resorption
Osteogenesis
Osteocytes
15 Citations (Scopus)

Examination of ERα signaling pathways in bone of mutant mouse models reveals the importance of ERE-dependent signaling

Chokalingam, K., Roforth, M. M., Nicks, K. M., McGregor, U., Fraser, D., Khosla, S. & Monroe, D. G., Nov 1 2012, In : Endocrinology. 153, 11, p. 5325-5333 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Bone and Bones
Genes
Estrogens
Response Elements
20 Citations (Scopus)

Examination of nuclear receptor expression in osteoblasts reveals rorβ as an important regulator of osteogenesis

Roforth, M. M., Liu, G., Khosla, S. & Monroe, D. G., Apr 2012, In : Journal of Bone and Mineral Research. 27, 4, p. 891-901 11 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Osteoblasts
Osteogenesis
Transcription Factors
Bone and Bones
25 Citations (Scopus)

Fracture risk in women with breast cancer: A population-based study

Melton, L. J., Hartmann, L. C., Achenbach, S. J., Atkinson, E. J., Therneau, T. M. & Khosla, S., May 2012, In : Journal of Bone and Mineral Research. 27, 5, p. 1196-1205 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Population
Spontaneous Fractures
Bone Density
Confidence Intervals
10 Citations (Scopus)

Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity

Bush, N. C., Basu, R., Rizza, R. A., Nair, K. S., Khosla, S. & Jensen, M. D., Nov 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 11, p. 4130-4138 9 p.

Research output: Contribution to journalArticle

Adiposity
Nonesterified Fatty Acids
Intra-Abdominal Fat
Palmitates
Insulin Resistance
43 Citations (Scopus)

Male Osteoporosis

Drake, M. M. & Khosla, S., Sep 2012, In : Endocrinology and Metabolism Clinics of North America. 41, 3, p. 629-641 13 p.

Research output: Contribution to journalArticle

Osteoporosis
Hip Fractures
Estradiol
Morbidity
Bone and Bones
18 Citations (Scopus)

Odanacatib: Location and timing are everything

Khosla, S., Mar 2012, In : Journal of Bone and Mineral Research. 27, 3, p. 506-508 3 p.

Research output: Contribution to journalArticle

Biphenyl Compounds
Bone Density Conservation Agents
Lumbar Vertebrae
Organ Size
Bone Remodeling
44 Citations (Scopus)

Osteocalcin positive CD133+/CD34-/KDR+ progenitor cells as an independent marker for unstable atherosclerosis

Flammer, A. J., Gössl, M., Widmer, R. J., Reriani, M., Lennon, R., Loeffler, D., Shonyo, S., Simari, R. D., Lerman, L. O., Khosla, S. & Lerman, A., Dec 2012, In : European Heart Journal. 33, 23, p. 2963-2969 7 p.

Research output: Contribution to journalArticle

Osteocalcin
Atherosclerosis
Stem Cells
Coronary Artery Disease
Cell Count
23 Citations (Scopus)

Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers

Flammer, A. J., Gössl, M., Li, J., Matsuo, Y., Reriani, M., Loeffler, D., Simari, R. D., Lerman, L. O., Khosla, S. & Lerman, A., Dec 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 12, p. 4761-4768 8 p.

Research output: Contribution to journalArticle

Osteocalcin
Endothelial cells
Cell Count
Vascular Calcification
Glycosylated Hemoglobin A
12 Citations (Scopus)

Potential extensions of the US FRAX algorithm

Melton, L. J., Atkinson, E. J., Achenbach, S. J., Kanis, J. A., Therneau, T. M., Johansson, H., Khosla, S. & Amin, S., 2012, In : Journal of Osteoporosis. 2012, 528790.

Research output: Contribution to journalArticle

Osteoporotic Fractures
Confidence Intervals
Bone Remodeling
Femur Neck
Bone Density
73 Citations (Scopus)

Relationship of age to bone microstructure independent of areal bone mineral density

Nicks, K. M., Amin, S., Atkinson, E. J., Riggs, B. L., Melton, L. J. & Khosla, S., Mar 2012, In : Journal of Bone and Mineral Research. 27, 3, p. 637-644 8 p.

Research output: Contribution to journalArticle

Bone Density
Bone and Bones
Bone Fractures
Photon Absorptiometry
Tomography
27 Citations (Scopus)

Relationship of femoral neck areal bone mineral density to volumetric bone mineral density, bone size, and femoral strength in men and women

Srinivasan, B., Kopperdahl, D. L., Amin, S., Atkinson, E. J., Camp, J., Robb, R. A., Riggs, B. L., Orwoll, E. S., Melton, L. J., Keaveny, T. M. & Khosla, S., Jan 2012, In : Osteoporosis International. 23, 1, p. 155-162 8 p.

Research output: Contribution to journalArticle

Femur Neck
Thigh
Bone Density
Bone and Bones
Photon Absorptiometry
32 Citations (Scopus)

Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women

Farr, J., Charkoudian, N., Barnes, J. N., Monroe, D. G., McCready, L. K., Atkinson, E. J., Amin, S., Melton, L. J., Joyner, M. J. & Khosla, S., Nov 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 11, p. 4219-4227 9 p.

Research output: Contribution to journalArticle

Osteopontin
Bone Remodeling
Bone
Plasmas
Microstructure
46 Citations (Scopus)

Role of circulating osteogenic progenitor cells in calcific aortic stenosis

Gössl, M., Khosla, S., Zhang, X., Higano, N., Jordan, K. L., Loeffler, D., Sarano, M. E., Lennon, R. J., Lerman, L. O. & Lerman, A., Nov 6 2012, In : Journal of the American College of Cardiology. 60, 19, p. 1945-1953 9 p.

Research output: Contribution to journalArticle

Osteocalcin
Stem Cells
Aortic Valve
Phenotype
Coronary Artery Disease
50 Citations (Scopus)

Sclerostin levels during growth in children

Kirmani, S., Amin, S., McCready, L. K., Atkinson, E. J., Melton, L. J., Müller, R. & Khosla, S., Mar 2012, In : Osteoporosis International. 23, 3, p. 1123-1130 8 p.

Research output: Contribution to journalArticle

Growth
Serum
Porosity
Puberty
Bone Remodeling
19 Citations (Scopus)
Tomography
Bone and Bones
Biopsy
Incidence
66 Citations (Scopus)
Insulin-Like Growth Factor Binding Protein 2
Skeletal Muscle
Bone and Bones
Serum
Femur Neck
23 Citations (Scopus)

TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction

Kumar, A., Ruan, M., Clifton, K., Syed, F., Khosla, S. & Oursler, M. J., Jan 2012, In : Endocrinology. 153, 1, p. 254-263 10 p.

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Adipogenesis
Adipocytes
Estradiol
Osteoblasts