• 39968 Citations
  • 102 Scopus h-Index
1976 …2021

Research output per year

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Research Output

2014

Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings

Egorov, V., Tatarinov, A., Sarvazyan, N., Wood, R., Magidenko, L., Amin, S., Khosla, S., Ruh, R. J., Ruh, J. M. & Sarvazyan, A., Jul 2014, In : Ultrasonics. 54, 5, p. 1170-1177 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Parathyroid Hormone in the Pathophysiology of Osteoporosis

Khosla, S., Sep 5 2014, The Parathyroids: Basic and Clinical Concepts: Third Edition. Elsevier Inc., p. 827-835 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Seeding Open Innovation Drug Discovery and Translational Collaborations to Leverage Government Funding: A Case Study of Strategic Partnership between Sanford-Burnham and Mayo Clinic

Chung, T. D. Y., Khosla, S., Badley, A. D. & Jackson, M. R., Apr 14 2014, Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships. Wiley Blackwell, p. 451-486 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

The clinical diagnosis of osteoporosis: A position statement from the National Bone Health Alliance Working Group

Siris, E. S., Adler, R., Bilezikian, J., Bolognese, M., Dawson-Hughes, B., Favus, M. J., Harris, S. T., Jan De Beur, S. M., Khosla, S., Lane, N. E., Lindsay, R., Nana, A. D., Orwoll, E. S., Saag, K., Silverman, S. & Watts, N. B., Jan 1 2014, In : Osteoporosis International. 25, 5, p. 1439-1443 5 p.

Research output: Contribution to journalArticle

193 Scopus citations

Trends in fracture incidence: A population-based study over 20 years

Amin, S., Achenbach, S. J., Atkinson, E. J., Khosla, S. & Melton, L. J., Mar 1 2014, In : Journal of Bone and Mineral Research. 29, 3, p. 581-589 9 p.

Research output: Contribution to journalArticle

97 Scopus citations

Validation of a CT-derived method for osteoporosis screening in IBD patients undergoing contrast-enhanced CT enterography

Weber, N. K., Fidler, J. L., Keaveny, T. M., Clarke, B. L., Khosla, S., Fletcher, J. G., Lee, D. C., Pardi, D. S., Loftus, E. V., Kane, S. V., Barlow, J. M., Murthy, N. S., Becker, B. D. & Bruining, D. H., Mar 2014, In : American Journal of Gastroenterology. 109, 3, p. 401-408 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women

Amin, S., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Dekutoski, M. B., Kirmani, S., Fischer, P. R. & Khosla, S., Aug 13 2013, In : Journal of Bone and Mineral Research. 28, 8, p. 1751-1759 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Applications of a new handheld reference point indentation instrument measuring bone material strength

Randall, C., Bridges, D., Guerri, R., Nogues, X., Puig, L., Torres, E., Mellibovsky, L., Hoffseth, K., Stalbaum, T., Srikanth, A., Weaver, J. C., Rosen, S., Barnard, H., Brimer, D., Proctor, A., Candy, J., Saldana, C., Chandrasekar, S., Lescun, T., Nielson, C. M. & 9 others, Orwoll, E., Herthel, D., Kopeikin, H., Yang, H. T. Y., Farr, J. N., McCready, L., Khosla, S., Diez-Perez, A. & Hansma, P. K., Sep 24 2013, In : Journal of Medical Devices, Transactions of the ASME. 7, 4, 041005.

Research output: Contribution to journalArticle

38 Scopus citations

Benefits and risks of bisphosphonate therapy for osteoporosis: Editorial comment

Khosla, S., Bilezikian, J. P., Dempster, D. W., Lewiecki, E. M., Miller, P. D., Neer, R. M., Recker, R. R., Shane, E., Shoback, D. & Potts, J. T., Jan 1 2013, In : Obstetrical and Gynecological Survey. 68, 1, p. 37-39 3 p.

Research output: Contribution to journalComment/debate

Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes

Klingberg, E., Lorentzon, M., Göthlin, J., Mellström, D., Geijer, M., Ohlsson, C., Atkinson, E. J., Khosla, S., Carlsten, H. & Forsblad-d'Elia, H., Nov 5 2013, In : Arthritis Research and Therapy. 15, 6, R179.

Research output: Contribution to journalArticle

46 Scopus citations

Effects of bisphosphonate treatment on circulating osteogenic endothelial progenitor cells in postmenopausal women

Peris, P., Atkinson, E. J., Gössl, M., Kane, T. L., McCready, L. K., Lerman, A., Khosla, S. & McGregor, U. I., Jan 2013, In : Mayo Clinic proceedings. 88, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
24 Scopus citations

Estrogen Deficiency, Postmenopausal Osteoporosis, and Age-Related Bone Loss

Khosla, S. & Pacifici, R., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1113-1136 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Identification of Rorβ targets in cultured osteoblasts and in human bone

Roforth, M. M., Khosla, S. & Monroe, D. G., Nov 1 2013, In : Biochemical and Biophysical Research Communications. 440, 4, p. 768-773 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Improved fracture risk assessment based on nonlinear micro-finite element simulations from HRpQCT images at the distal radius

Christen, D., Melton, L. J., Zwahlen, A., Amin, S., Khosla, S. & Müller, R., Dec 1 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2601-2608 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Longitudinal changes in lumbar bone mineral density distribution may increase the risk of wedge fractures

Giambini, H., Khosla, S., Nassr, A., Zhao, C. & An, K. N., Jan 1 2013, In : Clinical Biomechanics. 28, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography

Burghardt, A. J., Pialat, J. B., Kazakia, G. J., Boutroy, S., Engelke, K., Patsch, J. M., Valentinitsch, A., Liu, D., Szabo, E., Bogado, C. E., Zanchetta, M. B., McKay, H. A., Shane, E., Boyd, S. K., Bouxsein, M. L., Chapurlat, R., Khosla, S. & Majumdar, S., Mar 1 2013, In : Journal of Bone and Mineral Research. 28, 3, p. 524-536 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

Osteonecrosis of the Jaw and Atypical Femoral Fractures

Shane, E., Khosla, S. & Burr, D., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1873-1908 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Pathogenesis of age-related bone loss in humans

Khosla, S., Oct 1 2013, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 68, 10, p. 1226-1235 10 p.

Research output: Contribution to journalArticle

102 Scopus citations

Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells

Flammer, A. J., Martin, E. A., Gössl, M., Widmer, R. J., Lennon, R. J., Sexton, J. A., Loeffler, D., Khosla, S., Lerman, L. O. & Lerman, A., Feb 1 2013, In : European Journal of Nutrition. 52, 1, p. 289-296 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Proximal femoral density distribution and structure in relation to age and hip fracture risk in women

Carballido-Gamio, J., Harnish, R., Saeed, I., Streeper, T., Sigurdsson, S., Amin, S., Atkinson, E. J., Therneau, T. M., Siggeirsdottir, K., Cheng, X., Melton, L. J., Keyak, J., Gudnason, V., Khosla, S., Harris, T. B. & Lang, T. F., Mar 1 2013, In : Journal of Bone and Mineral Research. 28, 3, p. 537-546 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Relationship of adiposity to bone volumetric density and microstructure in men and women across the adult lifespan

Ng, A. C., Melton, L. J., Atkinson, E. J., Achenbach, S. J., Holets, M. F., Peterson, J. M., Khosla, S. & Drake, M. T., Mar 11 2013, In : Bone. 55, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Aug 1 2013, In : Journal of cellular biochemistry. 114, 8, p. 1901-1907 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Structural patterns of the proximal femur in relation to age and hip fracture risk in women

Carballido-Gamio, J., Harnish, R., Saeed, I., Streeper, T., Sigurdsson, S., Amin, S., Atkinson, E. J., Therneau, T. M., Siggeirsdottir, K., Cheng, X., Melton, L. J., Keyak, J. H., Gudnason, V., Khosla, S., Harris, T. B. & Lang, T. F., Nov 1 2013, In : Bone. 57, 1, p. 290-299 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Oct 1 2013, In : Endocrinology. 154, 10, p. 3745-3752 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

The Role of Sex Steroids in the Pathogenesis of Osteoporosis

Drake, M. M. & Khosla, S., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 367-375 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Three-dimensional structural analysis of the proximal femur in an age-stratified sample of women

Nicks, K. M., Amin, S., Melton, L. J., Atkinson, E. J., McCready, L. K., Riggs, B. L., Engelke, K. & Khosla, S., Mar 14 2013, In : Bone. 55, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

Ota, K., Quint, P., Weivoda, M. M., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Nov 1 2013, In : Bone. 57, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

A DNA binding mutation in estrogen receptor-α Leads to suppression of Wnt signaling via β-catenin destabilization in osteoblasts

Mödder, U. I., Rudnik, V., Liu, G., Khosla, S. & Monroe, D. G., Jul 1 2012, In : Journal of cellular biochemistry. 113, 7, p. 2248-2255 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Age-dependent renal cortical microvascular loss in female mice

Urbieta-Caceres, V. H., Syed, F. A., Lin, J., Zhu, X. Y., Jordan, K. L., Bell, C. C., Bentley, M. D., Lerman, A., Khosla, S. & Lerman, L. O., Apr 15 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 8, p. E979-E986

Research output: Contribution to journalArticle

20 Scopus citations

Assessing fracture risk using gradient boosting machine (GBM) models

Atkinson, E. J., Therneau, T. M., Melton, L. J., Camp, J. J., Achenbach, S. J., Amin, S. & Khosla, S., Jun 1 2012, In : Journal of Bone and Mineral Research. 27, 6, p. 1397-1404 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Benefits and risks of bisphosphonate therapy for osteoporosis

Khosla, S., Bilezikian, J. P., Dempster, D. W., Lewiecki, E. M., Miller, P. D., Neer, R. M., Recker, R. R., Shane, E., Shoback, D. & Potts, J. T., Jul 1 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 7, p. 2272-2282 11 p.

Research output: Contribution to journalReview article

152 Scopus citations

Better tools for assessing osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., Dec 3 2012, In : Journal of Clinical Investigation. 122, 12, p. 4323-4324 2 p.

Research output: Contribution to journalShort survey

10 Scopus citations

Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: A nested substudy of the MAP.3 randomised controlled trial

Cheung, A. M., Tile, L., Cardew, S., Pruthi, S., Robbins, J., Tomlinson, G., Kapral, M. K., Khosla, S., Majumdar, S., Erlandson, M., Scher, J., Hu, H., Demaras, A., Lickley, L., Bordeleau, L., Elser, C., Ingle, J., Richardson, H. & Goss, P. E., Mar 1 2012, In : The Lancet Oncology. 13, 3, p. 275-284 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Characterization of mesenchymal progenitor cells isolated from human bone marrow by negative selection

Mödder, U. I., Roforth, M. M., Nicks, K. M., Peterson, J. M., McCready, L. K., Monroe, D. G. & Khosla, S., Mar 1 2012, In : Bone. 50, 3, p. 804-810 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Emerging role of circulating calcifying cells in the bone-vascular axis

Fadini, G. P., Rattazzi, M., Matsumoto, T., Asahara, T. & Khosla, S., Jun 5 2012, In : Circulation. 125, 22, p. 2772-2781 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Erratum: Role of circulating osteogenic progenitor cells in calcific aortic stenosis (Journal of the American College of Cardiology (2012) 60 (194553))

Gössl, M., Khosla, S., Zhang, X., Higano, N., Jordan, K. L., Loeffler, D., Enriquez-Sarano, M., Lennon, R. J., McGregor, U., Lerman, L. O. & Lerman, A., Dec 18 2012, In : Journal of the American College of Cardiology. 60, 24, 1 p.

Research output: Contribution to journalComment/debate

Estrogen and the skeleton

Khosla, S., Oursler, M. J. & Monroe, D. G., Nov 1 2012, In : Trends in Endocrinology and Metabolism. 23, 11, p. 576-581 6 p.

Research output: Contribution to journalReview article

234 Scopus citations

Examination of ERα signaling pathways in bone of mutant mouse models reveals the importance of ERE-dependent signaling

Chokalingam, K., Roforth, M. M., Nicks, K. M., McGregor, U., Fraser, D., Khosla, S. & Monroe, D. G., Nov 1 2012, In : Endocrinology. 153, 11, p. 5325-5333 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Examination of nuclear receptor expression in osteoblasts reveals rorβ as an important regulator of osteogenesis

Roforth, M. M., Liu, G., Khosla, S. & Monroe, D. G., Apr 1 2012, In : Journal of Bone and Mineral Research. 27, 4, p. 891-901 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Fracture risk in women with breast cancer: A population-based study

Melton, L. J., Hartmann, L. C., Achenbach, S. J., Atkinson, E. J., Therneau, T. M. & Khosla, S., May 1 2012, In : Journal of Bone and Mineral Research. 27, 5, p. 1196-1205 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity

Bush, N. C., Basu, R., Rizza, R. A., Nair, K. S., Khosla, S. & Jensen, M. D., Nov 1 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 11, p. 4130-4138 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Male Osteoporosis

Drake, M. T. & Khosla, S., Sep 1 2012, In : Endocrinology and Metabolism Clinics of North America. 41, 3, p. 629-641 13 p.

Research output: Contribution to journalReview article

44 Scopus citations

Odanacatib: Location and timing are everything

Khosla, S., Mar 1 2012, In : Journal of Bone and Mineral Research. 27, 3, p. 506-508 3 p.

Research output: Contribution to journalComment/debate

21 Scopus citations

Osteocalcin positive CD133+/CD34-/KDR+ progenitor cells as an independent marker for unstable atherosclerosis

Flammer, A. J., Gössl, M., Widmer, R. J., Reriani, M., Lennon, R., Loeffler, D., Shonyo, S., Simari, R. D., Lerman, L. O., Khosla, S. & Lerman, A., Dec 1 2012, In : European heart journal. 33, 23, p. 2963-2969 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers

Flammer, A. J., Gössl, M., Li, J., Matsuo, Y., Reriani, M., Loeffler, D., Simari, R. D., Lerman, L. O., Khosla, S. & Lerman, A., Dec 1 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 12, p. 4761-4768 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Potential extensions of the US FRAX algorithm

Melton, L. J., Atkinson, E. J., Achenbach, S. J., Kanis, J. A., Therneau, T. M., Johansson, H., Khosla, S. & Amin, S., Jan 1 2012, In : Journal of Osteoporosis. 2012, 528790.

Research output: Contribution to journalArticle

12 Scopus citations

Relationship of age to bone microstructure independent of areal bone mineral density

Nicks, K. M., Amin, S., Atkinson, E. J., Riggs, B. L., Melton, L. J. & Khosla, S., Mar 1 2012, In : Journal of Bone and Mineral Research. 27, 3, p. 637-644 8 p.

Research output: Contribution to journalArticle

73 Scopus citations

Relationship of femoral neck areal bone mineral density to volumetric bone mineral density, bone size, and femoral strength in men and women

Srinivasan, B., Kopperdahl, D. L., Amin, S., Atkinson, E. J., Camp, J., Robb, R. A., Riggs, B. L., Orwoll, E. S., Melton, L. J., Keaveny, T. M. & Khosla, S., Jan 1 2012, In : Osteoporosis International. 23, 1, p. 155-162 8 p.

Research output: Contribution to journalArticle

28 Scopus citations