• 39968 Citations
  • 102 Scopus h-Index
1976 …2021

Research output per year

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Research Output

2002

Fracture risk in primary hyperparathyroidism

Khosla, S. & Melton, L. J., Nov 1 2002, In : Journal of Bone and Mineral Research. 17, SUPPL. 2, p. N103-N107

Research output: Contribution to journalArticle

69 Scopus citations

Oestrogen, bones and men: When testosterone just isn't enough

Khosla, S., Apr 25 2002, In : Clinical Endocrinology. 56, 3, p. 291-293 3 p.

Research output: Contribution to journalComment/debate

17 Scopus citations

Osteopenia in adults with a history of juvenile rheumatoid arthritis. A population based study

French, A. R., Mason, T., Nelson, A. M., Crowson, C. S., O'Fallon, W. M., Khosla, S. & Gabriel, S. E., May 20 2002, In : Journal of Rheumatology. 29, 5, p. 1065-1070 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells

Hofbauer, L. C., Hicok, K. C., Chen, D. & Khosla, S., Aug 2002, In : European journal of endocrinology. 147, 2, p. 269-273 5 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women

Heshmati, H. M., Khosla, S., Robins, S. P., O'Fallon, W. M., Melton, L. J. & Riggs, B. L., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 1, p. 172-178 7 p.

Research output: Contribution to journalArticle

162 Scopus citations

Secondary osteoporosis and the risk of distal forearm fractures in men and women

Melton, L. J., Achenbach, S. J., O'fallon, W. M. & Khosla, S., Jan 1 2002, In : Bone. 31, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Sex steroids and the construction and conservation of the adult skeleton

Riggs, B. L., Khosla, S. & Melton, L. J., Jan 1 2002, In : Endocrine Reviews. 23, 3, p. 279-302 24 p.

Research output: Contribution to journalReview article

1244 Scopus citations

Sex steroids and the construction and conservation of the adult skeleton

Riggs, B. L., Khosla, S. & Melton, L. J., 2002, In : Endocrine Reviews. 23, 3, p. 279-302 24 p.

Research output: Contribution to journalArticle

Subcutaneous administration of insulin-like growth (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

Conover, C. A., Johnstone, E. W., Turner, R. T., Evans, G. L., John Ballard, F., Doran, P. M. & Khosla, S., Jun 2002, In : Growth Hormone and IGF Research. 12, 3, p. 178-183 6 p.

Research output: Contribution to journalArticle

59 Scopus citations
50 Scopus citations
Open Access
27 Scopus citations
2001

Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology

Locklin, R. M., Riggs, B. L., Hicok, K. C., Horton, H. F., Byrne, M. C. & Khosla, S., Jan 1 2001, In : Journal of Bone and Mineral Research. 16, 12, p. 2192-2204 13 p.

Research output: Contribution to journalArticle

71 Scopus citations

Effects of immunosuppressants on receptor activator of NF-κB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells

Hofbauer, L. C., Shui, C., Riggs, B. L., Dunstan, C. R., Spelsberg, T. C., O'Brien, T. & Khosla, S., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 280, 1, p. 334-339 6 p.

Research output: Contribution to journalArticle

179 Scopus citations

Effects of raloxifene, a selective estrogen receptor modulator, on bone turnover markers and serum sex steroid and lipid levels in elderly men

Doran, P. M., Riggs, B. L., Atkinson, E. J. & Khosla, S., Jan 1 2001, In : Journal of Bone and Mineral Research. 16, 11, p. 2118-2125 8 p.

Research output: Contribution to journalArticle

93 Scopus citations

Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

Waters, K. M., Rickard, D. J., Lawrence Riggs, B., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Moore, J. & Spelsberg, T. C., Nov 13 2001, In : Journal of cellular biochemistry. 83, 3, p. 448-462 15 p.

Research output: Contribution to journalArticle

71 Scopus citations

Estrogens and bone health in men

Khosla, S., Melton, L. J. & Riggs, B. L., Nov 17 2001, In : Calcified Tissue International. 69, 4, p. 189-192 4 p.

Research output: Contribution to journalArticle

61 Scopus citations

Leptin reduces ovariectomy-induced bone loss in rats

Burguera, B., Hofbauer, L. C., Thomas, T., Gori, F., Evans, G. L., Khosla, S., Riggs, B. L. & Turner, R. T., Jan 1 2001, In : Endocrinology. 142, 8, p. 3546-3553 8 p.

Research output: Contribution to journalArticle

Open Access
248 Scopus citations

Minireview: The OPG/RANKL/RANK system

Khosla, S., Jan 1 2001, In : Endocrinology. 142, 12, p. 5050-5055 6 p.

Research output: Contribution to journalShort survey

Open Access
1034 Scopus citations
Open Access
66 Scopus citations

Regulation of osteoclastogenesis and RANK expression by TGF-β1

Yan, T., Riggs, B. L., Boyle, W. J. & Khosla, S., Oct 6 2001, In : Journal of cellular biochemistry. 83, 2, p. 320-325 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men

Khosla, S., Melton, L. J., Atkinson, E. J. & O'Fallon, W. M., Jan 1 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 8, p. 3555-3561 7 p.

Research output: Contribution to journalArticle

Open Access
396 Scopus citations

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., Aug 21 2001, In : Bone. 29, 2, p. 114-120 7 p.

Research output: Contribution to journalArticle

240 Scopus citations
2000

Cross-sectional versus longitudinal evaluation of bone loss in men and women

Melton, L. J., Khosla, S., Atkinson, E. J., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., Oct 14 2000, In : Osteoporosis International. 11, 7, p. 592-599 8 p.

Research output: Contribution to journalArticle

95 Scopus citations

Cytokine-specific induction of the TGF-β inducible early gene (TIEG): Regulation by specific members of the TGF-β family

Hefferan, T. E., Subramaniam, M., Khosla, S., Riggs, B. L. & Spelsberg, T. C., Aug 9 2000, In : Journal of cellular biochemistry. 78, 3, p. 380-390 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men

Melton, L. J., Khosla, S., Achenbach, S. J., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., Dec 1 2000, In : Osteoporosis International. 11, 11, p. 977-983 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

Epidemiology of sarcopenia

Melton, L. J., Khosla, S., Crowson, C. S., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., Jun 1 2000, In : Journal of the American Geriatrics Society. 48, 6, p. 625-630 6 p.

Research output: Contribution to journalArticle

361 Scopus citations

Epidemiology of sarcopenia

Melton, J. L., Khosla, S. & Lawrence Riggs, B., Jan 1 2000, In : Mayo Clinic proceedings. 75, SUPPL., p. S10-S13

Research output: Contribution to journalArticle

66 Scopus citations

Etidronate for osteoporosis in primary biliary cirrhosis: A randomized trial

Lindor, K. D., Jorgensen, R. A., Tiegs, R. D., Khosla, S. & Dickson, E. R., Jan 1 2000, In : Journal of hepatology. 33, 6, p. 878-882 5 p.

Research output: Contribution to journalArticle

62 Scopus citations

Fractures following thyroidectomy in women: A population-based cohort study

Melton, L. J., Ardila, E., Crowson, C. S., O'Fallon, W. M. & Khosla, S., Nov 13 2000, In : Bone. 27, 5, p. 695-700 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Primary osteoporosis in men: role of sex steroid deficiency

Lawrence Riggs, B., Khosla, S. & Joseph Melton, L., Jan 1 2000, In : Mayo Clinic proceedings. 75, SUPPL., p. S46-S50

Research output: Contribution to journalArticle

19 Scopus citations

Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: Evidence for age-related intestinal resistance to 1,25(OH)2D action

Pattanaungkul, S., Riggs, B. L., Yergey, A. L., Vieira, N. E., O'Fallon, W. M. & Khosla, S., Dec 1 2000, In : Journal of Clinical Endocrinology and Metabolism. 85, 11, p. 4023-4027 5 p.

Research output: Contribution to journalArticle

107 Scopus citations

Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., Jan 1 2000, In : Metabolism: Clinical and Experimental. 49, 10, p. 1278-1284 7 p.

Research output: Contribution to journalArticle

135 Scopus citations

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men

Falahati-Nini, A., Riggs, B. L., Atkinson, E. J., O'Fallon, W. M., Eastell, R. & Khosla, S., Jan 1 2000, In : Journal of Clinical Investigation. 106, 12, p. 1553-1560 8 p.

Research output: Contribution to journalArticle

Open Access
555 Scopus citations

Relative influence of physical activity, muscle mass and strength on bone density

Proctor, D. N., Melton, L. J., Khosla, S., Crowson, C. S., O'Connor, M. K. & Riggs, B. L., Dec 1 2000, In : Osteoporosis International. 11, 11, p. 944-952 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

The effects of androgens on osteoblast function in vitro

Khosla, S., Jan 1 2000, In : Mayo Clinic proceedings. 75, SUPPL., p. S51-S54

Research output: Contribution to journalArticle

4 Scopus citations

The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated

Gori, F., Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Khosla, S. & Lawrence Riggs, B., Jan 1 2000, In : Endocrinology. 141, 12, p. 4768-4776 9 p.

Research output: Contribution to journalArticle

Open Access
241 Scopus citations

The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption

Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Boyle, W. J. & Riggs, B. L., Jan 1 2000, In : Journal of Bone and Mineral Research. 15, 1, p. 2-12 11 p.

Research output: Contribution to journalReview article

946 Scopus citations
1999

Androgen effects on bone metabolism: Recent progress and controversies

Hofbauer, L. C. & Khosla, S., Apr 1 1999, In : European journal of endocrinology. 140, 4, p. 271-286 16 p.

Research output: Contribution to journalReview article

115 Scopus citations

Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line

Gori, F., Hofbauer, L. C., Conover, C. A. & Khosla, S., Jan 1 1999, In : Endocrinology. 140, 12, p. 5579-5586 8 p.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations

Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells

Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Spelsberg, T. C. & Riggs, B. L., Jan 1 1999, In : Endocrinology. 140, 9, p. 4367-4370 4 p.

Research output: Contribution to journalArticle

Open Access
535 Scopus citations

Fracture risk after surgery for peptic ulcer disease: A population-based cohort study

Melton, L. J., Crowson, C. S., Khosla, S. & O'Fallon, W. M., Jul 1 1999, In : Bone. 25, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Immunoradiometric assay for intact human osteocalcin(I-49) without cross-reactivity to breakdown products

Colford, J. W., Lueddecke, B. A., Salvati, M., Hanna, D., Sailer, D., Khosla, S., Riggs, B. L. & Langman, C. B., Jan 1 1999, In : Clinical chemistry. 45, 4, p. 526-531 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

Hofbauer, L. C., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Sep 1 1999, In : Bone. 25, 3, p. 255-259 5 p.

Research output: Contribution to journalArticle

493 Scopus citations

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B. & Riggs, B. L., Jan 1 1999, In : Endocrinology. 140, 4, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

Open Access
597 Scopus citations

Osteology: further debate.

Kleerekoper, M., Deftos, L., Khosla, S., Marcus, R., Matrici, M., McClung, M., Rosen, C. & Shane, E., Jun 1 1999, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14, 6, 1 p.

Research output: Contribution to journalLetter

Osteoporosis: Gender differences and similarities

Khosla, S., Melton, L. J. & Riggs, B. L., Jan 1 1999, In : Lupus. 8, 5, p. 393-396 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Primary hyperparathyroidism and the risk of fracture: A population-based study

Khosla, S., Melton, L. J., Wermers, R. A., Crowson, C. S., O'Fallon, W. M. & Riggs, B. L., Oct 7 1999, In : Journal of Bone and Mineral Research. 14, 10, p. 1700-1707 8 p.

Research output: Contribution to journalArticle

276 Scopus citations

Response of bipotential human marrow stromal cells to insulin-like growth factors: Effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes

Thomas, T., Gori, F., Spelsberg, T. C., Khosla, S., Riggs, B. L. & Conover, C. A., Jan 1 1999, In : Endocrinology. 140, 11, p. 5036-5044 9 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations

Secondary osteoporosis and the risk of vertebral deformities in women

Melton, L. J., Atkinson, E. J., Khosla, S., O'Fallon, W. M. & Riggs, B. L., Jan 1 1999, In : Bone. 24, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis

Hofbauer, L. C., Gori, F., Riggs, B. L., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C. & Khosla, S., Jan 1 1999, In : Endocrinology. 140, 10, p. 4382-4389 8 p.

Research output: Contribution to journalArticle

Open Access
578 Scopus citations