• 38865 Citations
  • 100 Scopus h-Index
1976 …2021
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Research Output 1980 2019

2002
1225 Citations (Scopus)

Sex steroids and the construction and conservation of the adult skeleton

Riggs, B. L., Khosla, S. & Melton, L. J., Jan 1 2002, In : Endocrine Reviews. 23, 3, p. 279-302 24 p.

Research output: Contribution to journalReview article

Skeleton
Steroids
Bone and Bones
Osteoporosis
Osteoblasts

Sex steroids and the construction and conservation of the adult skeleton

Riggs, B. L., Khosla, S. & Melton, L. J., 2002, In : Endocrine Reviews. 23, 3, p. 279-302 24 p.

Research output: Contribution to journalArticle

Skeleton
Steroids
Bone and Bones
Osteoporosis
Osteoblasts
56 Citations (Scopus)

Subcutaneous administration of insulin-like growth (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

Conover, C. A., Johnstone, E. W., Turner, R. T., Evans, G. L., John Ballard, F., Doran, P. M. & Khosla, S., Jun 2002, In : Growth Hormone and IGF Research. 12, 3, p. 178-183 6 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor II
Osteogenesis
Bone Density
Osteoporosis
49 Citations (Scopus)
RANK Ligand
Transforming Growth Factors
Osteoclasts
Sirolimus
Immunosuppressive Agents
26 Citations (Scopus)
Osteosclerosis
Hepatitis C
Hypoglycemia
Tumors
Insulin-Like Growth Factor Binding Protein 2
2001
71 Citations (Scopus)

Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology

Locklin, R. M., Riggs, B. L., Hicok, K. C., Horton, H. F., Byrne, M. C. & Khosla, S., 2001, In : Journal of Bone and Mineral Research. 16, 12, p. 2192-2204 13 p.

Research output: Contribution to journalArticle

Stromal Cells
Bone Marrow
Bone Morphogenetic Protein 2
Technology
Genes
177 Citations (Scopus)

Effects of immunosuppressants on receptor activator of NF-κB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells

Hofbauer, L. C., Shui, C., Riggs, B. L., Dunstan, C. R., Spelsberg, T. C., O'Brien, T. & Khosla, S., 2001, In : Biochemical and Biophysical Research Communications. 280, 1, p. 334-339 6 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoprotegerin
Immunosuppressive Agents
Smooth Muscle Myocytes
Muscle
92 Citations (Scopus)

Effects of raloxifene, a selective estrogen receptor modulator, on bone turnover markers and serum sex steroid and lipid levels in elderly men

Doran, P. M., Riggs, B. L., Atkinson, E. J. & Khosla, S., 2001, In : Journal of Bone and Mineral Research. 16, 11, p. 2118-2125 8 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Bone Remodeling
Biomarkers
Steroids
Lipids
70 Citations (Scopus)

Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

Waters, K. M., Rickard, D. J., Lawrence Riggs, B., Khosla, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Moore, J. & Spelsberg, T. C., 2001, In : Journal of Cellular Biochemistry. 83, 3, p. 448-462 15 p.

Research output: Contribution to journalArticle

Osteoblasts
Estrogen Receptors
Tamoxifen
Protein Isoforms
Estrogens
61 Citations (Scopus)

Estrogens and bone health in men

Khosla, S., Melton, L. J. & Riggs, B. L., 2001, In : Calcified Tissue International. 69, 4, p. 189-192 4 p.

Research output: Contribution to journalArticle

Men's Health
Estrogens
Bone and Bones
Testosterone
Bone Density
246 Citations (Scopus)

Leptin reduces ovariectomy-induced bone loss in rats

Burguera, B., Hofbauer, L. C., Thomas, T., Gori, F., Evans, G. L., Khosla, S., Riggs, B. L. & Turner, R. T., 2001, In : Endocrinology. 142, 8, p. 3546-3553 8 p.

Research output: Contribution to journalArticle

Ovariectomy
Leptin
Bone and Bones
RANK Ligand
Fat Body
1022 Citations (Scopus)

Minireview: The OPG/RANKL/RANK system

Khosla, S., 2001, In : Endocrinology. 142, 12, p. 5050-5055 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Stromal Cells
Osteogenesis
Bone and Bones
Osteopetrosis
66 Citations (Scopus)
Estrogen Replacement Therapy
Coagulation
Estrogens
Prospective Studies
C-Reactive Protein
80 Citations (Scopus)

Regulation of osteoclastogenesis and RANK expression by TGF-β1

Yan, T., Riggs, B. L., Boyle, W. J. & Khosla, S., 2001, In : Journal of Cellular Biochemistry. 83, 2, p. 320-325 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Osteogenesis
Receptor Activator of Nuclear Factor-kappa B
Macrophage Colony-Stimulating Factor
Osteoclasts
388 Citations (Scopus)

Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men

Khosla, S., Melton, L. J., Atkinson, E. J. & O'Fallon, W. M., 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 8, p. 3555-3561 7 p.

Research output: Contribution to journalArticle

Bone Density
Bone
Steroids
Serum
Estradiol
237 Citations (Scopus)

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., 2001, In : Bone. 29, 2, p. 114-120 7 p.

Research output: Contribution to journalArticle

Leptin
Bone Density
Estrogens
Fats
Insulin
2000
93 Citations (Scopus)

Cross-sectional versus longitudinal evaluation of bone loss in men and women

Melton, L. J., Khosla, S., Atkinson, E. J., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., 2000, In : Osteoporosis International. 11, 7, p. 592-599 8 p.

Research output: Contribution to journalArticle

Bone and Bones
Bone Density
Hormone Replacement Therapy
Photon Absorptiometry
Forearm
38 Citations (Scopus)

Cytokine-specific induction of the TGF-β inducible early gene (TIEG): Regulation by specific members of the TGF-β family

Hefferan, T. E., Subramaniam, M., Khosla, S., Riggs, B. L. & Spelsberg, T. C., 2000, In : Journal of Cellular Biochemistry. 78, 3, p. 380-390 11 p.

Research output: Contribution to journalArticle

Gene expression
Genes
Cytokines
Bone Morphogenetic Protein 6
Activins
85 Citations (Scopus)

Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men

Melton, L. J., Khosla, S., Achenbach, S. J., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., 2000, In : Osteoporosis International. 11, 11, p. 977-983 7 p.

Research output: Contribution to journalArticle

Body Size
Bone Density
Osteoporosis
Bone and Bones
Spine
354 Citations (Scopus)

Epidemiology of sarcopenia

Melton, L. J., Khosla, S., Crowson, C., O'Connor, M. K., O'Fallon, W. M. & Riggs, B. L., Jun 2000, In : Journal of the American Geriatrics Society. 48, 6, p. 625-630 6 p.

Research output: Contribution to journalArticle

Sarcopenia
Epidemiology
Muscles
Paraphilic Disorders
Photon Absorptiometry
65 Citations (Scopus)

Epidemiology of sarcopenia

Melton, J. L., Khosla, S. & Lawrence Riggs, B., 2000, In : Mayo Clinic Proceedings. 75, SUPPL.

Research output: Contribution to journalArticle

Sarcopenia
Epidemiology
Morbidity
60 Citations (Scopus)

Etidronate for osteoporosis in primary biliary cirrhosis: A randomized trial

Lindor, K. D., Jorgensen, R. A., Tiegs, R. D., Khosla, S. & Dickson, E. R., 2000, In : Journal of Hepatology. 33, 6, p. 878-882 5 p.

Research output: Contribution to journalArticle

Etidronic Acid
Biliary Liver Cirrhosis
Osteoporosis
Bone Density
Spine
14 Citations (Scopus)

Fractures following thyroidectomy in women: A population-based cohort study

Melton, L. J., Ardila, E., Crowson, C., O'Fallon, W. M. & Khosla, S., 2000, In : Bone. 27, 5, p. 695-700 6 p.

Research output: Contribution to journalArticle

Thyroidectomy
Cohort Studies
Population
Hyperthyroidism
Confidence Intervals

Primary osteoporosis in men: role of sex steroid deficiency.

Riggs, B. L., Khosla, S. & Melton, L. J., Jan 2000, In : Mayo Clinic Proceedings. 75 Suppl

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Steroids
Bone and Bones
Causality
19 Citations (Scopus)

Primary osteoporosis in men: role of sex steroid deficiency

Lawrence Riggs, B., Khosla, S. & Joseph Melton, L., 2000, In : Mayo Clinic Proceedings. 75, SUPPL.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Steroids
Bone and Bones
Causality
105 Citations (Scopus)

Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: Evidence for age-related intestinal resistance to 1,25(OH)2D action

Pattanaungkul, S., Riggs, B. L., Yergey, A. L., Vieira, N. E., O'Fallon, W. M. & Khosla, S., 2000, In : Journal of Clinical Endocrinology and Metabolism. 85, 11, p. 4023-4027 5 p.

Research output: Contribution to journalArticle

Intestinal Absorption
Calcium
Nutrition
Diet
Calcium Isotopes
135 Citations (Scopus)

Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women

Thomas, T., Burguera, B., Melton, L. J., Atkinson, E. J., O'Fallon, W. M., Riggs, B. L. & Khosla, S., 2000, In : Metabolism: Clinical and Experimental. 49, 10, p. 1278-1284 7 p.

Research output: Contribution to journalArticle

Leptin
Body Composition
Steroids
Insulin
Serum
546 Citations (Scopus)

Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men

Falahati-Nini, A., Riggs, B. L., Atkinson, E. J., O'Fallon, W. M., Eastell, R. & Khosla, S., 2000, In : Journal of Clinical Investigation. 106, 12, p. 1553-1560 8 p.

Research output: Contribution to journalArticle

Bone Resorption
Osteogenesis
Testosterone
Estrogens
Bone Remodeling
85 Citations (Scopus)

Relative influence of physical activity, muscle mass and strength on bone density

Proctor, D. N., Melton, L. J., Khosla, S., Crowson, C., O'Connor, M. K. & Riggs, B. L., 2000, In : Osteoporosis International. 11, 11, p. 944-952 9 p.

Research output: Contribution to journalArticle

Muscle Strength
Bone Density
Exercise
Hand Strength
Muscles
4 Citations (Scopus)

The effects of androgens on osteoblast function in vitro

Khosla, S., 2000, In : Mayo Clinic Proceedings. 75, SUPPL.

Research output: Contribution to journalArticle

Osteoblasts
Androgens
Bone and Bones
Estrogens
Transformed Cell Line
236 Citations (Scopus)

The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated

Gori, F., Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Khosla, S. & Lawrence Riggs, B., 2000, In : Endocrinology. 141, 12, p. 4768-4776 9 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoclasts
Osteoblasts
Osteoprotegerin
Bone Remodeling
934 Citations (Scopus)

The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption

Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Boyle, W. J. & Riggs, B. L., 2000, In : Journal of Bone and Mineral Research. 15, 1, p. 2-12 11 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoprotegerin
Bone Resorption
Osteoclasts
Cytokines
1999
114 Citations (Scopus)

Androgen effects on bone metabolism: Recent progress and controversies

Hofbauer, L. C. & Khosla, S., Apr 1999, In : European Journal of Endocrinology. 140, 4, p. 271-286 16 p.

Research output: Contribution to journalArticle

Androgens
Bone and Bones
Androgen Receptors
Androgen Receptor Antagonists
Insulin-Like Growth Factor Binding Proteins
70 Citations (Scopus)

Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line

Gori, F., Hofbauer, L. C., Conover, C. A. & Khosla, S., 1999, In : Endocrinology. 140, 12, p. 5579-5586 8 p.

Research output: Contribution to journalArticle

Somatomedins
Androgens
Insulin-Like Growth Factor I
Cell Line
Insulin-Like Growth Factor Binding Proteins
532 Citations (Scopus)

Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells

Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Spelsberg, T. C. & Riggs, B. L., 1999, In : Endocrinology. 140, 9, p. 4367-4370 4 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Estrogens
Estrogen Receptors
Gene Expression
Proteins
30 Citations (Scopus)

Fracture risk after surgery for peptic ulcer disease: A population-based cohort study

Melton, L. J., Crowson, C., Khosla, S. & O'Fallon, W. M., Jul 1999, In : Bone. 25, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

Peptic Ulcer
Cohort Studies
Population
Incidence
Forearm
7 Citations (Scopus)

Immunoradiometric assay for intact human osteocalcin(I-49) without cross-reactivity to breakdown products

Colford, J. W., Lueddecke, B. A., Salvati, M., Hanna, D., Sailer, D., Khosla, S., Riggs, B. L. & Langman, C. B., 1999, In : Clinical Chemistry. 45, 4, p. 526-531 6 p.

Research output: Contribution to journalArticle

Immunoradiometric Assay
Osteocalcin
Assays
Plasmas
Edetic Acid
490 Citations (Scopus)

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

Hofbauer, L. C., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L. & Khosla, S., Sep 1999, In : Bone. 25, 3, p. 255-259 5 p.

Research output: Contribution to journalArticle

RANK Ligand
Interleukin-1
Interleukin-6
Tumor Necrosis Factor-alpha
Gene Expression
594 Citations (Scopus)

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B. & Riggs, B. L., 1999, In : Endocrinology. 140, 4, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

Stromal Cells
Leptin
Osteoblasts
Adipocytes
Bone Marrow

Osteology: further debate.

Kleerekoper, M., Deftos, L., Khosla, S., Marcus, R., Matrici, M., McClung, M., Rosen, C. & Shane, E., Jun 1999, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14, 6, p. 1017 1 p.

Research output: Contribution to journalArticle

Osteology
Metabolic Bone Diseases
32 Citations (Scopus)

Osteoporosis: Gender differences and similarities

Khosla, S., Melton, L. J. & Riggs, B. L., 1999, In : Lupus. 8, 5, p. 393-396 4 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Bone and Bones
Postmenopausal Osteoporosis
Bone Resorption
270 Citations (Scopus)

Primary hyperparathyroidism and the risk of fracture: A population-based study

Khosla, S., Melton, L. J., Wermers, R. A., Crowson, C., O'Fallon, W. M. & Riggs, B. L., 1999, In : Journal of Bone and Mineral Research. 14, 10, p. 1700-1707 8 p.

Research output: Contribution to journalArticle

Primary Hyperparathyroidism
Confidence Intervals
Incidence
Population
Osteitis Fibrosa Cystica
74 Citations (Scopus)

Response of bipotential human marrow stromal cells to insulin-like growth factors: Effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes

Thomas, T., Gori, F., Spelsberg, T. C., Khosla, S., Riggs, B. L. & Conover, C. A., 1999, In : Endocrinology. 140, 11, p. 5036-5044 9 p.

Research output: Contribution to journalArticle

Somatomedins
Stromal Cells
Osteoblasts
Adipocytes
Carrier Proteins
34 Citations (Scopus)

Secondary osteoporosis and the risk of vertebral deformities in women

Melton, L. J., Atkinson, E. J., Khosla, S., O'Fallon, W. M. & Riggs, B. L., Jan 1999, In : Bone. 24, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Osteoporosis
Hip Fractures
Forearm
Anticoagulants
Weights and Measures
569 Citations (Scopus)

Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: Potential paracrine mechanisms of glucocorticoid-induced osteoporosis

Hofbauer, L. C., Gori, F., Riggs, B. L., Lacey, D. L., Dunstan, C. R., Spelsberg, T. C. & Khosla, S., 1999, In : Endocrinology. 140, 10, p. 4382-4389 8 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoprotegerin
Glucocorticoids
Osteoporosis
Dexamethasone
200 Citations (Scopus)

The actions and interactions of sex steroids and growth factors/cytokines on the skeleton

Spelsberg, T. C., Subramaniam, M., Riggs, B. L. & Khosla, S., 1999, In : Molecular Endocrinology. 13, 6, p. 819-828 10 p.

Research output: Contribution to journalArticle

Growth Substances
Sex Factors
Osteoprotegerin
Estrogen Receptor beta
Estrogen Receptor alpha
59 Citations (Scopus)
Androgens
Interleukin-6
Cell Line
Androgen Receptors
Androgen Receptor Antagonists
38 Citations (Scopus)

The assembly of the adult skeleton during growth and maturation: Implications for senile osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., 1999, In : Journal of Clinical Investigation. 104, 6, p. 671-672 2 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Bone Development
Puberty
Skeleton
Bone Density
1998
29 Citations (Scopus)

A defect in renal calcium conservation may contribute to the pathogenesis of postmenopausal osteoporosis

Heshmati, H. M., Khosla, S., Burritt, M. F., O'fallon, W. M. & Riggs, B. L., 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 6, p. 1916-1920 5 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Conservation
Calcium
Kidney
Defects
832 Citations (Scopus)
Postmenopausal Osteoporosis
Osteoporosis
Estrogens
Bone and Bones
Calcium