• 38820 Citations
  • 100 Scopus h-Index
1976 …2021
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1980 2019

2010
64 Citations (Scopus)

Relation of vertebral deformities to bone density, structure, and strength

Melton, L. J., Riggs, B. L., Keaveny, T. M., Achenbach, S. J., Kopperdahl, D., Camp, J. J., Rouleau, P. A., Amin, S., Atkinson, E. J., Robb, R. A., Therneau, T. M. & Khosla, S., Sep 2010, In : Journal of Bone and Mineral Research. 25, 9, p. 1922-1930 9 p.

Research output: Contribution to journalArticle

Bone Density
Compressive Strength
Finite Element Analysis
Osteoporotic Fractures
Spine
60 Citations (Scopus)

The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis

DuSell, C. D., Nelson, E. R., Wang, X., Abdo, J., Mödder, U. I., Umetani, M., Gesty-Palmer, D., Javitt, N. B., Khosla, S. & McDonnell, D. P., Aug 2010, In : Endocrinology. 151, 8, p. 3675-3685 11 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Homeostasis
Bone and Bones
Estrogens
Cholesterol
119 Citations (Scopus)

Update in male osteoporosis

Khosla, S., Jan 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

Osteoporosis
Bone
Tomography
Estradiol
Teriparatide
112 Citations (Scopus)

Update on estrogens and the skeleton

Khosla, S., Aug 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 8, p. 3569-3577 9 p.

Research output: Contribution to journalArticle

Skeleton
Estrogens
Bone
Bone and Bones
Tissue
2009
112 Citations (Scopus)

Androgens and bone

Clarke, B. & Khosla, S., Mar 2009, In : Steroids. 74, 3, p. 296-305 10 p.

Research output: Contribution to journalArticle

Androgens
Testosterone
Bone
Bone and Bones
Estradiol
1 Citation (Scopus)

Assessing the true impact of recurrent fractures on fracture risk

Clarke, B. & Khosla, S., 2009, In : Journal of Bone and Mineral Research. 24, 9, p. 1512-1514 3 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Bone Fractures
Photon Absorptiometry
Bone Density
Recurrence
122 Citations (Scopus)

Bisphosphonate associated osteonecrosis of the jaw

Khan, A. A., Sándor, G. K. B., Dore, E., Morrison, A. D., Alsahli, M., Amin, F., Peters, E., Hanley, D. A., Chaudry, S. R., Lentle, B., Dempster, D. W., Glorieux, F. H., Neville, A. J., Talwar, R. M., Clokie, C. M., Al Mardini, M., Paul, T., Khosla, S., Josse, R. G., Sutherland, S. & 10 others, Lam, D. K., Carmichael, R. P., Blanas, N., Kendler, D., Petak, S., Ste-Marie, L. G., Brown, J., Evans, A. W., Rios, L. & Compston, J. E., Mar 2009, In : Journal of Rheumatology. 36, 3, p. 478-490 13 p.

Research output: Contribution to journalArticle

Bisphosphonate-Associated Osteonecrosis of the Jaw
Diphosphonates
Jaw
Osteoporosis
Osteonecrosis
173 Citations (Scopus)

Bone structure at the distal radius during adolescent growth

Kirmani, S., Christen, D., Van Lenthe, G. H., Fischer, P. R., Bouxsein, M. L., McCready, L. K., Melton, L. J., Riggs, B. L., Amin, S., Müller, R. & Khosla, S., Jun 2009, In : Journal of Bone and Mineral Research. 24, 6, p. 1033-1042 10 p.

Research output: Contribution to journalArticle

Puberty
Forearm
Bone and Bones
Growth
Age Groups
15 Citations (Scopus)

Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo

Clowes, J. A., Eghbali-Fatourechi, G. Z., McCready, L., Oursler, M. J., Khosla, S. & Riggs, B. L., May 2009, In : Osteoporosis International. 20, 5, p. 761-769 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Receptors, Tumor Necrosis Factor, Type II
Estrogens
Bone Marrow Cells
Bone Marrow
20 Citations (Scopus)

Fatty acid metabolism in the elderly: Effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women

Koutsari, C., Ali, A. H., Nair, K. S., Rizza, R. A., O'Brien, P., Khosla, S. & Jensen, M. D., Sep 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 9, p. 3414-3423 10 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Metabolism
Testosterone
Fatty Acids
Fats
70 Citations (Scopus)
Creatinine
Demography
Muscles
Chronic Renal Insufficiency
Cardiovascular Diseases
62 Citations (Scopus)

Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements

Henderson, G. C., Dhatariya, K., Ford, G. C., Klaus, K. A., Basu, R., Rizza, R. A., Jensen, M. D., Khosla, S., O'Brien, P. & Nair, K. S., Feb 2009, In : FASEB Journal. 23, 2, p. 631-641 11 p.

Research output: Contribution to journalArticle

Muscle Proteins
Androgens
Dehydroepiandrosterone
Energy Metabolism
Muscle
57 Citations (Scopus)

Increasing options for the treatment of osteoporosis

Khosla, S., Aug 20 2009, In : New England Journal of Medicine. 361, 8, p. 818-820 3 p.

Research output: Contribution to journalArticle

Osteoporosis
128 Citations (Scopus)

Mesenchymal stem cells for bone repair and metabolic bone diseases

Undale, A. H., Westendorf, J. J., Yaszemski, M. J. & Khosla, S., 2009, In : Mayo Clinic Proceedings. 84, 10, p. 893-902 10 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Mesenchymal Stromal Cells
Cell- and Tissue-Based Therapy
Bone and Bones
Hypophosphatasia
28 Citations (Scopus)

New selective estrogen and androgen receptor modulators

Clarke, B. & Khosla, S., Jul 2009, In : Current Opinion in Rheumatology. 21, 4, p. 374-379 6 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Androgen Receptors
Clinical Trials
Estrogen Receptors
Tamoxifen
4 Citations (Scopus)

Role of Sex Steroids in the Pathogenesis of Osteoporosis

Drake, M. M. & Khosla, S., Dec 23 2009, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition. John Wiley & Sons, Inc., p. 208-213 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Menopause
Osteoporosis
Testosterone
Estrogens
Steroids
22 Citations (Scopus)

Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2

Mödder, U. I., Monroe, D. G., Fraser, D. G., Spelsberg, T. C., Rosen, C. J., Géhin, M., Chambon, P., O'Malley, B. W. & Khosla, S., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 18767-18777 11 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 2
Peroxisome Proliferator-Activated Receptors
Bone
Knockout Mice
Adipocytes
42 Citations (Scopus)

Targeting bone remodeling for the treatment of osteoporosis: summary of the proceedings of an ASBMR workshop

Bilezikian, J. P., Matsumoto, T., Bellido, T., Khosla, S., Martin, J., Recker, R. R., Heaney, R., Seeman, E., Papapoulos, S. & Goldring, S. R., Mar 2009, In : Journal of Bone and Mineral Research. 24, 3, p. 373-385 13 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone Resorption
Osteogenesis
Osteoporosis
Education
3 Citations (Scopus)

Testosterone: More is not always better

Khosla, S., Dec 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 12, p. 4665-4667 3 p.

Research output: Contribution to journalArticle

Testosterone
2008
32 Citations (Scopus)

Abdominal aortic calcification, BMD, and bone microstructure: A population-based study

Chow, J. T., Khosla, S., Melton, L. J., Atkinson, E. J., Camp, J. J. & Kearns, A. E., Oct 2008, In : Journal of Bone and Mineral Research. 23, 10, p. 1601-1612 12 p.

Research output: Contribution to journalArticle

Social Adjustment
Bone and Bones
Population
Vascular Calcification
Femur Neck
107 Citations (Scopus)

A bone structural basis for fracture risk in diabetes

Melton, L. J., Riggs, B. L., Leibson, C. L., Achenbach, S. J., Camp, J. J., Bouxsein, M. L., Atkinson, E. J., Robb, R. A. & Khosla, S., Dec 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 12, p. 4804-4809 6 p.

Research output: Contribution to journalArticle

Medical problems
Bone
Bone and Bones
Bone Density
Pelvic Bones
322 Citations (Scopus)

A population-based assessment of rates of bone loss at multiple skeletal sites: Evidence for substantial trabecular bone loss in young adult women and men

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., McDaniel, L., Amin, S., Rouleau, P. A. & Khosla, S., Feb 2008, In : Journal of Bone and Mineral Research. 23, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

Young Adult
Bone and Bones
Population
Tibia
Perimenopause
599 Citations (Scopus)

Bisphosphonates: Mechanism of action and role in clinical practice

Drake, M. M., Clarke, B. & Khosla, S., 2008, In : Mayo Clinic Proceedings. 83, 9, p. 1032-1045 14 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoclasts
Osteitis Deformans
Bone and Bones
Osteogenesis Imperfecta
24 Citations (Scopus)

Bone growth and turnover in progesterone receptor knockout mice

Rickard, D. J., Iwaniec, U. T., Evans, G., Hefferan, T. E., Hunter, J. C., Waters, K. M., Lydon, J. P., O'Malley, B. W., Khosla, S., Spelsberg, T. C. & Turner, R. T., May 2008, In : Endocrinology. 149, 5, p. 2383-2390 8 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone Development
Progesterone Receptors
Knockout Mice
Tibia
5 Citations (Scopus)

Bone-targeted replacement therapy for hypophosphatasia

Drake, M. M. & Khosla, S., Jun 2008, In : Journal of Bone and Mineral Research. 23, 6, p. 775-776 2 p.

Research output: Contribution to journalArticle

Hypophosphatasia
Biological Therapy
Alkaline Phosphatase
Bone and Bones
Therapeutics
266 Citations (Scopus)

Building bone to reverse osteoporosis and repair fractures

Khosla, S., Westendorf, J. J. & Oursler, M. J., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 421-428 8 p.

Research output: Contribution to journalArticle

Osteoporosis
Fracture Healing
Bone and Bones
Spinal Fractures
Bone Morphogenetic Protein 2
148 Citations (Scopus)

Canadian consensus practice guidelines for bisphosphonate associated osteonecrosis of the jaw

Khan, A. A., Sándor, G. K. B., Dore, E., Morrison, A. D., Alsahli, M., Amin, F., Peters, E., Hanley, D. A., Chaudry, S. R., Dempster, D. W., Glorieux, F. H., Neville, A. J., Talwar, R. M., Clokie, C. M., Al Mardini, M., Paul, T., Khosla, S., Josse, R. G., Sutherland, S., Lam, D. K. & 9 others, Carmichael, R. P., Blanas, N., Kendler, D., Petak, S., St.-Marie, L. G., Brown, J., Evans, A. W., Rios, L. & Compston, J. E., Jul 2008, In : Journal of Rheumatology. 35, 7, p. 1391-1397 7 p.

Research output: Contribution to journalArticle

Bisphosphonate-Associated Osteonecrosis of the Jaw
Osteonecrosis
Diphosphonates
Jaw
Practice Guidelines
56 Citations (Scopus)
Immunoassay
Bone Density
Mass Spectrometry
Steroids
Serum
313 Citations (Scopus)

Cost-effective osteoporosis treatment thresholds: The United States perspective

Tosteson, A. N. A., Melton, L. J., Dawson-Hughes, B., Baim, S., Favus, M. J., Khosla, S. & Lindsay, R. L., Apr 2008, In : Osteoporosis International. 19, 4, p. 437-447 11 p.

Research output: Contribution to journalArticle

Hip Fractures
Osteoporosis
Health Care Costs
Costs and Cost Analysis
Quality-Adjusted Life Years

Cost-effective osteoporosis treatment thresholds: The United States perspective

Tosteson, A. N. A., Melton, L. J., Dawson-Hughes, B., Bairn, S., Favus, M. J., Khosla, S. & Lindsay, R. L., Aug 2008, In : Obstetrical and Gynecological Survey. 63, 8, p. 516-517 2 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women

Syed, F. A., Oursler, M. J., Hefferanm, T. E., Peterson, J. M., Riggs, B. L. & Khosla, S., Sep 2008, In : Osteoporosis International. 19, 9, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

Adipocytes
Estrogens
Bone Marrow
Therapeutics
Placebos
8 Citations (Scopus)

Estrogen, Bone Homeostasis, and Osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., 2008, Osteoporosis, Two-Volume Set. Elsevier Inc., p. 1011-1039 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone
Estrogens
36 Citations (Scopus)

Estrogen and bone: Insights from estrogen-resistant, aromatase-deficient, and normal men

Khosla, S., Sep 2008, In : Bone. 43, 3, p. 414-417 4 p.

Research output: Contribution to journalArticle

Aromatase
Estrogens
Bone and Bones
Bone Remodeling
Skeleton
26 Citations (Scopus)

Estrogen and fracture risk in men

Gennari, L., Khosla, S. & Bilezikian, J. P., Oct 2008, In : Journal of Bone and Mineral Research. 23, 10, p. 1548-1551 4 p.

Research output: Contribution to journalArticle

Bone Fractures
Bone Density
Estrogens
3 Citations (Scopus)

Estrogen Effects on Bone in the Male Skeleton

Gennari, L., Khosla, S. & Bilezikian, J. P., 2008, Principles of Bone Biology, Two-Volume Set. Elsevier Inc., Vol. 2. p. 1801-1818 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Skeleton
Bone
Estrogens
Bone and Bones
Androgens
35 Citations (Scopus)
Transforming Growth Factors
Osteoblasts
Estrogen Receptors
Protein Isoforms
Genes
217 Citations (Scopus)

Fracture risk in type 2 diabetes: Update of a population-based study

Melton, L. J., Leibson, C. L., Achenbach, S. J., Therneau, T. M. & Khosla, S., Aug 2008, In : Journal of Bone and Mineral Research. 23, 8, p. 1334-1342 9 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Hip Fractures
Population
Incidence
Osteoporosis
302 Citations (Scopus)

Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA

Dawson-Hughes, B., Tosteson, A. N. A., Melton, L. J., Baim, S., Favus, M. J., Khosla, S. & Lindsay, R. L., Apr 2008, In : Osteoporosis International. 19, 4, p. 449-458 10 p.

Research output: Contribution to journalArticle

Practice Guidelines
Osteoporosis
Hip Fractures
Health Care Costs
Economics
1 Citation (Scopus)

Insulin-like growth factor binding protein-2: A novel regulator of skeletal gender differences?

Khosla, S., May 2008, In : Endocrinology. 149, 5, p. 2048-2050 3 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Biological Models
Organ Size
Bone Development
Knockout Mice
15 Citations (Scopus)

Loss of ERE binding activity by estrogen receptor-α alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells

Rudnik, V., Sanyal, A., Syed, F. A., Monroe, D. G., Spelsberg, T. C., Oursler, M. J. & Khosla, S., Feb 15 2008, In : Journal of Cellular Biochemistry. 103, 3, p. 896-907 12 p.

Research output: Contribution to journalArticle

Response Elements
Gene expression
Estrogen Receptors
Bone
Estrogens
45 Citations (Scopus)
Jaw Diseases
Bisphosphonate-Associated Osteonecrosis of the Jaw
Bone Density Conservation Agents
Osteonecrosis
Diphosphonates
116 Citations (Scopus)

Osteocalcin Expression by Circulating Endothelial Progenitor Cells in Patients With Coronary Atherosclerosis

Gössl, M., Mödder, U. I., Atkinson, E. J., Lerman, A. & Khosla, S., Oct 14 2008, In : Journal of the American College of Cardiology. 52, 16, p. 1314-1325 12 p.

Research output: Contribution to journalArticle

Osteocalcin
Coronary Artery Disease
Vascular Endothelial Growth Factor Receptor-2
Coronary Vessels
Endothelial Progenitor Cells
233 Citations (Scopus)

Osteoporosis in men

Khosla, S., Amin, S. & Orwoll, E., Jun 2008, In : Endocrine Reviews. 29, 4, p. 441-464 24 p.

Research output: Contribution to journalArticle

Osteoporosis
Reference Values
Hip Fractures
Diphosphonates
Osteoblasts
509 Citations (Scopus)

Receptor activator of nuclear factor κB ligand and osteoprotegerin regulation of bone remodeling in health and disease

Kearns, A. E., Khosla, S. & Kostenuik, P. J., Apr 2008, In : Endocrine Reviews. 29, 2, p. 155-192 38 p.

Research output: Contribution to journalArticle

RANK Ligand
Bone Remodeling
Cytoplasmic and Nuclear Receptors
Bone and Bones
Health
308 Citations (Scopus)
Osteoclasts
Chemokines
Osteogenesis
Osteoblasts
Bone and Bones
21 Citations (Scopus)

Regulation of bone turnover by sex steroids in men

Sanyal, A., Hoey, K. A., Mödder, U. I., Lamsam, J. L., McCready, L. K., Peterson, J. M., Achenbach, S. J., Oursler, M. J. & Khosla, S., May 2008, In : Journal of Bone and Mineral Research. 23, 5, p. 705-714 10 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone Resorption
Steroids
Follicle Stimulating Hormone
Interleukin-1
40 Citations (Scopus)

Serum biomarker profile associated with high bone turnover and BMD in postmenopausal women

Bhattacharyya, S., Siegel, E. R., Achenbach, S. J., Khosla, S. & Suva, L. J., Jul 2008, In : Journal of Bone and Mineral Research. 23, 7, p. 1106-1117 12 p.

Research output: Contribution to journalArticle

Bone Remodeling
Biomarkers
Serum
Dermatoglyphics
Plasma Kallikrein
50 Citations (Scopus)
Bone Remodeling
Stem cells
Bone
Stem Cells
Osteoblasts
18 Citations (Scopus)

The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice

Mödder, U. I., Sanyal, A., Xu, J., O'Malley, B. W., Spelsberg, T. C. & Khosla, S., Feb 2008, In : Bone. 42, 2, p. 414-421 8 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 1
Knockout Mice
Estrogens
Bone Remodeling
Bone and Bones
9 Citations (Scopus)

Use of renal function measurements for assessing fracture risk in postmenopausal women

McCarthy, J. T., Rule, A. D., Achenbach, S. J., Bergstralh, E. J., Khosla, S. & Melton, L. J., 2008, In : Mayo Clinic Proceedings. 83, 11, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

Creatinine
Kidney
Bone Density
Body Weight
Glomerular Filtration Rate