• 40590 Citations
  • 102 Scopus h-Index
1976 …2021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Comment/debate

Personalising osteoporosis treatment for patients at high risk of fracture

Khosla, S., Oct 1 2019, In : The Lancet Diabetes and Endocrinology. 7, 10, p. 739-741 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Placebo-controlled fracture trials in osteoporosis - Comment on the article by Stein and Ray

Rosen, C. J. & Khosla, S., Sep 30 2010, In : New England Journal of Medicine. 363, 14, p. e21

Research output: Contribution to journalComment/debate

1 Scopus citations

Skeletal considerations in the medical treatment of transgender people

Khosla, S. & Davidge-Pitts, C., Dec 2019, In : The Lancet Diabetes and Endocrinology. 7, 12, p. 893-895 3 p.

Research output: Contribution to journalComment/debate

The assembly of the adult skeleton during growth and maturation: Implications for senile osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., Jan 1 1999, In : Journal of Clinical Investigation. 104, 6, p. 671-672 2 p.

Research output: Contribution to journalComment/debate

Open Access
39 Scopus citations
Chapter

Bone quality in type 2 diabetes mellitus

Farr, J. & Khosla, S., Jan 1 2016, Diabetic Bone Disease: Basic and Translational Research and Clinical Applications. Springer International Publishing, p. 211-224 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Estrogen, Bone Homeostasis, and Osteoporosis

Riggs, B. L., Khosla, S. & Melton, L. J., Dec 1 2008, Osteoporosis, Two-Volume Set. Elsevier Inc., p. 1011-1039 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Estrogen Deficiency, Postmenopausal Osteoporosis, and Age-Related Bone Loss

Khosla, S. & Pacifici, R., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1113-1136 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Estrogen Effects on Bone in the Male Skeleton

Gennari, L., Khosla, S. & Bilezikian, J. P., Dec 1 2008, Principles of Bone Biology, Two-Volume Set. Elsevier Inc., Vol. 2. p. 1801-1818 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Estrogens and progestins

Monroe, D. G. & Khosla, S., Jan 1 2019, Principles of Bone Biology. Elsevier, p. 827-837 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Osteonecrosis of the Jaw and Atypical Femoral Fractures

Shane, E., Khosla, S. & Burr, D., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1873-1908 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Parathyroid Hormone in the Pathophysiology of Osteoporosis

Khosla, S., Sep 5 2014, The Parathyroids: Basic and Clinical Concepts: Third Edition. Elsevier Inc., p. 827-835 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Role of Sex Steroids in the Pathogenesis of Osteoporosis

Drake, M. T. & Khosla, S., Dec 23 2009, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition. John Wiley & Sons, Inc., p. 208-213 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Seeding Open Innovation Drug Discovery and Translational Collaborations to Leverage Government Funding: A Case Study of Strategic Partnership between Sanford-Burnham and Mayo Clinic

Chung, T. D. Y., Khosla, S., Badley, A. D. & Jackson, M. R., Apr 14 2014, Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships. Wiley Blackwell, p. 451-486 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Sex Steroid Effects on Bone Metabolism

Monroe, D. G., Spelsberg, T. C. & Khosla, S., Dec 1 2006, Dynamics of Bone and Cartilage Metabolism. Elsevier Inc., p. 327-343 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Sex steroids and the pathogenesis of osteoporosis

Drake, M. M. & Khosla, S., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 412-418 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

The Role of Androgens and Estrogens in the Male Skeleton

Khosla, S. & Bilezikian, J. P., Dec 1 2004, Principles of Gender-Specific Medicine. Elsevier Inc., Vol. 2. p. 1021-1032 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The Role of Sex Steroids in the Pathogenesis of Osteoporosis

Drake, M. M. & Khosla, S., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 367-375 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations
Article

{A figure is presented} Long-term fracture risk among women with proven endometriosis

Melton, L. J., Leibson, C. L., Good, A. E., Achenbach, S. J., Oberg, A. L. & Khosla, S., Dec 1 2006, In : Fertility and Sterility. 86, 6, p. 1576-1583 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Abdominal aortic calcification, BMD, and bone microstructure: A population-based study

Chow, J. T., Khosla, S., Melton, L. J., Atkinson, E. J., Camp, J. J. & Kearns, A. E., Oct 1 2008, In : Journal of Bone and Mineral Research. 23, 10, p. 1601-1612 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Ability of circulating human hematopoietic lineage negative cells to support hematopoiesis

Peris, P., Roforth, M. M., Nicks, K. M., Fraser, D., Fujita, K., Jilka, R. L., Khosla, S. & McGregor, U., Jan 1 2015, In : Journal of Cellular Biochemistry. 116, 1, p. 58-66 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Abnormalities of parathyroid hormone secretion in elderly women that are reversible by short term therapy with 1,25-dihydroxyvitamin D3

Ledger, G. A., Burritt, M. F., Kao, P. C., O’fallon, W. M., Riggs, B. L. & Khosla, S., Jul 1994, In : Journal of Clinical Endocrinology and Metabolism. 79, 1, p. 211-216 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

A bone structural basis for fracture risk in diabetes

Melton, L. J., Riggs, B. L., Leibson, C. L., Achenbach, S. J., Camp, J. J., Bouxsein, M. L., Atkinson, E. J., Robb, R. A. & Khosla, S., Dec 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 12, p. 4804-4809 6 p.

Research output: Contribution to journalArticle

109 Scopus citations

Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

Eckhardt, B. A., Rowsey, J. L., Thicke, B. S., Fraser, D. G., O'Grady, K. L., Bondar, O. P., Hines, J. M., Singh, R. J., Thoreson, A. R., Rakshit, K., Lagnado, A. B., Passos, J. F., Vella, A., Matveyenko, A. V., Khosla, S., Monroe, D. G. & Farr, J. N., May 7 2020, In : JCI Insight. 5, 9

Research output: Contribution to journalArticle

Open Access

ACTH AND INDOMETHACIN‐INDUCED ANTIDIURESIS IN LOW SALT BRATTLEBORO STRAIN RATS: INDUCTION AND ESCAPE

Khosla, S., Kinter, L. B., Zusman, R. & Beeuwkes, R., Oct 1982, In : Annals of the New York Academy of Sciences. 394, 1, p. 265-269 5 p.

Research output: Contribution to journalArticle

Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward

Khosla, S., Cauley, J. A., Compston, J., Kiel, D. P., Rosen, C., Saag, K. G. & Shane, E., Mar 1 2017, In : Journal of Bone and Mineral Research. 32, 3, p. 424-430 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

A defect in renal calcium conservation may contribute to the pathogenesis of postmenopausal osteoporosis

Heshmati, H. M., Khosla, S., Burritt, M. F., O'fallon, W. M. & Riggs, B. L., Nov 11 1998, In : Journal of Clinical Endocrinology and Metabolism. 83, 6, p. 1916-1920 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women

Amin, S., Melton, L. J., Achenbach, S. J., Atkinson, E. J., Dekutoski, M. B., Kirmani, S., Fischer, P. R. & Khosla, S., Aug 13 2013, In : Journal of Bone and Mineral Research. 28, 8, p. 1751-1759 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

A DNA binding mutation in estrogen receptor-α Leads to suppression of Wnt signaling via β-catenin destabilization in osteoblasts

Mödder, U. I., Rudnik, V., Liu, G., Khosla, S. & Monroe, D. G., Jul 1 2012, In : Journal of cellular biochemistry. 113, 7, p. 2248-2255 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Adrenal crisis in the setting of high-dose ketoconazole therapy

Khosla, S., Wolfson, J. S., Demerjian, Z. & Godine, J. E., Jan 1 1989, In : Archives of internal medicine. 149, 4, p. 802-804 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel

Sampson, U. K. A., McGlynn, E. A., Perlin, J. B., Frisse, M. E., Arnold, S. B., Benz, E. J., Brennan, T., Briss, P., Beeuwkes Buntin, M. J., Khosla, S., King, R. G., Kuntz, R., Leider, H., Ling, S. M., Macrae, J., Murray, R., Thrailkill, E., Wager, C., Witchey, D. & Jacobson, H. R., Jan 1 2018, (Accepted/In press) In : Global Heart.

Research output: Contribution to journalArticle

A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors

Nagel, D. E., Khosla, S., Sanyal, A., Rosen, D. M., Kumagai, Y. & Riggs, B. L., Dec 1 2004, In : Journal of cellular biochemistry. 93, 6, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Age- and sex-specific differences in the factor of risk for vertebral fracture: A population-based study using QCT

Bouxsein, M. L., Melton, L. J., Riggs, B. L., Muller, J., Atkinson, E. J., Oberg, A. L., Robb, R. A., Camp, J. J., Rouleau, P. A., McCollough, C. H. & Khosla, S., Sep 1 2006, In : Journal of Bone and Mineral Research. 21, 9, p. 1475-1482 8 p.

Research output: Contribution to journalArticle

117 Scopus citations

Age-dependence of femoral strength in white women and men

Keaveny, T. M., Kopperdahl, D. L., Melton, L. J., Hoffmann, P. F., Amin, S., Riggs, B. L. & Khosla, S., May 1 2010, In : Journal of Bone and Mineral Research. 25, 5, p. 994-1001 8 p.

Research output: Contribution to journalArticle

114 Scopus citations

Age-dependent renal cortical microvascular loss in female mice

Urbieta-Caceres, V. H., Syed, F. A., Lin, J., Zhu, X. Y., Jordan, K. L., Bell, C. C., Bentley, M. D., Lerman, A., Khosla, S. & Lerman, L. O., Apr 15 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 8, p. E979-E986

Research output: Contribution to journalArticle

20 Scopus citations

Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study

Lee, T. H., Setty, P. T., Parthasarathy, G., Bailey, K. R., Wood-Wentz, C. M., Fletcher, J. G., Takahashi, N. M., Khosla, S., Moynagh, M. R., Zinsmeister, A. R. & Bharucha, A. E., Sep 1 2018, In : Mayo Clinic Proceedings. 93, 9, p. 1256-1265 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
1 Scopus citations

Androgens and bone

Clarke, B. L. & Khosla, S., Mar 1 2009, In : Steroids. 74, 3, p. 296-305 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

A population-based assessment of rates of bone loss at multiple skeletal sites: Evidence for substantial trabecular bone loss in young adult women and men

Riggs, B. L., Melton, L. J., Robb, R. A., Camp, J. J., Atkinson, E. J., McDaniel, L., Amin, S., Rouleau, P. A. & Khosla, S., Feb 1 2008, In : Journal of Bone and Mineral Research. 23, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

336 Scopus citations

A potentially deleterious role of IGFBP-2 on bone density in aging men and women

Amin, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Melton, L. J. & Khosla, S., Jul 1 2004, In : Journal of Bone and Mineral Research. 19, 7, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Applications of a new handheld reference point indentation instrument measuring bone material strength

Randall, C., Bridges, D., Guerri, R., Nogues, X., Puig, L., Torres, E., Mellibovsky, L., Hoffseth, K., Stalbaum, T., Srikanth, A., Weaver, J. C., Rosen, S., Barnard, H., Brimer, D., Proctor, A., Candy, J., Saldana, C., Chandrasekar, S., Lescun, T., Nielson, C. M. & 9 others, Orwoll, E., Herthel, D., Kopeikin, H., Yang, H. T. Y., Farr, J. N., McCready, L., Khosla, S., Diez-Perez, A. & Hansma, P. K., Sep 24 2013, In : Journal of Medical Devices, Transactions of the ASME. 7, 4, 041005.

Research output: Contribution to journalArticle

39 Scopus citations

A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy

ASPREE Investigator Group, Aug 2016, In : Injury Prevention. 22, 4, p. 297-301 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
6 Scopus citations

Aromatase inhibitor-associated bone fractures: A case-cohort GWAS and functional genomics

Liu, M., Goss, P. E., Ingle, J. N., Kubo, M., Furukawa, Y., Batzler, A., Jenkins, G. D., Carlson, E. E., Nakamura, Y., Schaid, D. J., Chapman, J. A. W., Shepherd, L. E., Ellis, M. J., Khosla, S., Wang, L. & Weinshilboum, R. M., Oct 1 2014, In : Molecular Endocrinology. 28, 10, p. 1740-1751 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Aspirin and fracture risk: A systematic review and exploratory meta-analysis of observational studies

Barker, A. L., Soh, S. E., Sanders, K. M., Pasco, J., Khosla, S., Ebeling, P. R., Ward, S. A., Peeters, G., Talevski, J., Cumming, R. G., Seeman, E. & McNeil, J. J., Feb 20 2020, In : BMJ open. 10, 2, 026876.

Research output: Contribution to journalArticle

Open Access

Assessing forearm fracture risk in postmenopausal women

Melton, L. J., Christen, D., Riggs, B. L., Achenbach, S. J., Müller, R., Van Lenthe, G. H., Amin, S., Atkinson, E. J. & Khosla, S., Jul 1 2010, In : Osteoporosis International. 21, 7, p. 1161-1169 9 p.

Research output: Contribution to journalArticle

86 Scopus citations

Assessing fracture risk using gradient boosting machine (GBM) models

Atkinson, E. J., Therneau, T. M., Melton, L. J., Camp, J. J., Achenbach, S. J., Amin, S. & Khosla, S., Jun 1 2012, In : Journal of Bone and Mineral Research. 27, 6, p. 1397-1404 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology

Locklin, R. M., Riggs, B. L., Hicok, K. C., Horton, H. F., Byrne, M. C. & Khosla, S., Jan 1 2001, In : Journal of Bone and Mineral Research. 16, 12, p. 2192-2204 13 p.

Research output: Contribution to journalArticle

72 Scopus citations

Association of hip strength estimates by finite-element analysis with fractures in women and men

Amin, S., Kopperdhal, D. L., Melton, L. J., Achenbach, S. J., Therneau, T. M., Riggs, B. L., Keaveny, T. M. & Khosla, S., Jul 1 2011, In : Journal of Bone and Mineral Research. 26, 7, p. 1593-1600 8 p.

Research output: Contribution to journalArticle

74 Scopus citations
849 Scopus citations

Beta-lactamase inactivation by mechanism-based reagents.

Fisher, J., Belasco, J. G., Charnas, R. L., Khosla, S. & Knowles, J. R., May 16 1980, In : Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 289, 1036, p. 309-319 11 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations