Michael John Ackerman, MD, PhD, FACC

  • 37462 Citations
  • 106 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2011

Genetic testing for potentially lethal, highly treatable inherited cardiomyopathies/channelopathies in clinical practice

Tester, D. J. & Ackerman, M. J., Mar 8 2011, In : Circulation. 123, 9, p. 1021-1037 17 p.

Research output: Contribution to journalArticle

146 Scopus citations

Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome

Barsheshet, A., Peterson, D. R., Moss, A. J., Schwartz, P. J., Kaufman, E. S., McNitt, S., Polonsky, S., Buber, J., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Towbin, J. A., Vincent, G. M., Zhang, L. & Goldenberg, I., Aug 1 2011, In : Heart rhythm. 8, 8, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Holter monitoring in the evaluation of congenital long QT syndrome

Mauriello, D. A., Johnson, J. N. & Ackerman, M. J., Sep 1 2011, In : PACE - Pacing and Clinical Electrophysiology. 34, 9, p. 1100-1104 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 2 others, Zipes, D. P. & Olson, S., Aug 2011, In : Europace. 13, 8, p. 1077-1109 33 p.

Research output: Contribution to journalArticle

455 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA)

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 1 others, Zipes, D. P., Aug 1 2011, In : Heart rhythm. 8, 8, p. 1308-1339 32 p.

Research output: Contribution to journalArticle

615 Scopus citations

HRS policy statement: Clinical cardiac electrophysiology fellowship curriculum: Update 2011

Link, M. S., Exner, D. V., Anderson, M., Ackerman, M., Al-Ahmad, A., Knight, B. P., Markowitz, S. M., Kaufman, E. S., Haines, D., Asirvatham, S. J., Callans, D. J., Mounsey, J. P., Bogun, F., Narayan, S. M., Krahn, A. D., Mittal, S., Singh, J., Fisher, J. D. & Chugh, S. S., Aug 2011, In : Heart rhythm. 8, 8, p. 1340-1356 17 p.

Research output: Contribution to journalArticle

9 Scopus citations

Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling

Landstrom, A. P., Kellen, C. A., Dixit, S. S., Van Oort, R. J., Garbino, A., Weisleder, N., Ma, J., Wehrens, X. H. T. & Ackerman, M. J., Mar 1 2011, In : Circulation: Heart Failure. 4, 2, p. 214-223 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Left cardiac sympathetic denervation in a pediatric patient with hypertrophic cardiomyopathy and recurrent ventricular fibrillation

Johnson, J. N., Harris, K. M., Moir, C., Lau, Y. R. & Ackerman, M. J., Oct 1 2011, In : Heart rhythm. 8, 10, p. 1591-1594 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Left ventricular noncompaction syndrome masquerading or misdiagnosed as congenital long QT syndrome: Remember QT prolongation does not equal long QT syndrome

Coleman, M. A., Bos, J. M., Phillips, S. D., Souza, J. J. & Ackerman, M. J., Sep 1 2011, In : Congenital Heart Disease. 6, 5, p. 492-498 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss-of-function mutations in the KCNJ8-Encoded Kir6.1 KATP channel and sudden infant death syndrome

Tester, D. J., Tan, B. H., Medeiros-Domingo, A., Song, C., Makielski, J. C. & Ackerman, M. J., Oct 1 2011, In : Circulation: Cardiovascular Genetics. 4, 5, p. 510-515 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations

Olivotto, I., Girolami, F., Sciagr, R., Ackerman, M. J., Sotgia, B., Bos, J. M., Nistri, S., Sgalambro, A., Grifoni, C., Torricelli, F., Camici, P. G. & Cecchi, F., Aug 16 2011, In : Journal of the American College of Cardiology. 58, 8, p. 839-848 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome

Migdalovich, D., Moss, A. J., Lopes, C. M., Costa, J., Ouellet, G., Barsheshet, A., McNitt, S., Polonsky, S., Robinson, J. L., Zareba, W., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Platonov, P. G., Shimizu, W., Towbin, J. A., Vincent, G. M., Wilde, A. A. M. & Goldenberg, I., Oct 2011, In : Heart rhythm. 8, 10, p. 1537-1543 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: Summary of the literature and implications for genetic testing

Landstrom, A. P., Adekola, B. A., Bos, J. M., Ommen, S. R. & Ackerman, M. J., Jan 1 2011, In : American Heart Journal. 161, 1, p. 165-171 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Prevalence and clinical correlates of QT prolongation in patients with hypertrophic cardiomyopathy

Johnson, J. N., Grifoni, C., Bos, J. M., Saber-Ayad, M., Ommen, S. R., Nistri, S., Cecchi, F., Olivotto, I. & Ackerman, M. J., May 2011, In : European heart journal. 32, 9, p. 1114-1120 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

QTc values among children and adolescents presenting to the emergency department

Van Dorn, C. S., Johnson, J. N., Taggart, N. W., Thorkelson, L. & Ackerman, M. J., Dec 2011, In : Pediatrics. 128, 6, p. e1395-e1401

Research output: Contribution to journalArticle

31 Scopus citations

R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation

Bartos, D. C., Duchatelet, S., Burgess, D. E., Klug, D., Denjoy, I., Peat, R., Lupoglazoff, J. M., Fressart, V., Berthet, M., Ackerman, M. J., January, C. T., Guicheney, P. & Delisle, B. P., Jan 2011, In : Heart rhythm. 8, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Risk factors for recurrent syncope and subsequent fatal or near-fatal events in children and adolescents with long QT syndrome

Liu, J. F., Jons, C., Moss, A. J., McNitt, S., Peterson, D. R., Qi, M., Zareba, W., Robinson, J. L., Barsheshet, A., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J., Vincent, M., Zhang, L. & Goldenberg, I., Feb 22 2011, In : Journal of the American College of Cardiology. 57, 8, p. 941-950 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals

Goldenberg, I., Horr, S., Moss, A. J., Lopes, C. M., Barsheshet, A., McNitt, S., Zareba, W., Andrews, M. L., Robinson, J. L., Locati, E. H., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Napolitano, C., Platonov, P. G., Priori, S. G., Qi, M., Schwartz, P. J., Shimizu, W., Towbin, J. A. & 3 others, Vincent, G. M., Wilde, A. A. M. & Zhang, L., Jan 4 2011, In : Journal of the American College of Cardiology. 57, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Open Access
169 Scopus citations

Risk of recurrent cardiac events after onset of menopause in women with congenital long-QT syndrome types 1 and 2

Buber, J., Mathew, J., Moss, A. J., Hall, W. J., Barsheshet, A., McNitt, S., Robinson, J. L., Zareba, W., Ackerman, M. J., Kaufman, E. S., Luria, D., Eldar, M., Towbin, J. A., Vincent, M. & Goldenberg, I., Jun 21 2011, In : Circulation. 123, 24, p. 2784-2791 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Risk of syncope in family members who are genotype-negative for a family-associated Long-QT syndrome mutation

Barsheshet, A., Moss, A. J., McNitt, S., Polonsky, S., Lopes, C. M., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Towbin, J. A., Vincent, G. M., Qi, M. & Goldenberg, I., Oct 1 2011, In : Circulation: Cardiovascular Genetics. 4, 5, p. 491-499 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Role of genetic testing for sudden death predisposing heart conditions in athletes

Landstrom, A. P., Tester, D. J. & Ackerman, M. J., Dec 1 2011, Sports Cardiology Essentials: Evaluation, Management and Case Studies. Springer New York, p. 85-100 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Slow QT interval adaptation to heart rate changes in normal ambulatory subjects

Razak, E., Buncová, M., Shusterman, V., Winter, B., Shen, W. K., Ackerman, M. J., Donovan, T., Lampert, R. & Němec, J., Apr 1 2011, In : Annals of Noninvasive Electrocardiology. 16, 2, p. 148-155 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

The achilles heel of cardiovascular genetic testing: Distinguishing pathogenic mutations from background genetic noise

Landstrom, A. P. & Ackerman, M. J., Oct 1 2011, In : Clinical pharmacology and therapeutics. 90, 4, p. 496-499 4 p.

Research output: Contribution to journalReview article

18 Scopus citations

The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680h to increase late Na current

Cheng, J., Tester, D. J., Tan, B. H., Valdivia, C. R., Kroboth, S., Ye, B., January, C. T., Ackerman, M. J. & Makielski, J. C., May 1 2011, In : Physiological Genomics. 43, 9, p. 461-466 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

The diagnostic utility of recovery phase QTc during treadmill exercise stress testing in the evaluation of long QT syndrome

Horner, J. M., Horner, M. M. & Ackerman, M. J., Nov 1 2011, In : Heart rhythm. 8, 11, p. 1698-1704 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

Transient outward current (I to) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome

Giudicessi, J. R., Ye, D., Tester, D. J., Crotti, L., Mugione, A., Nesterenko, V. V., Albertson, R. M., Antzelevitch, C., Schwartz, P. J. & Ackerman, M. J., Jul 1 2011, In : Heart rhythm. 8, 7, p. 1024-1032 9 p.

Research output: Contribution to journalArticle

168 Scopus citations

Unexplained drownings and the cardiac channelopathies: A molecular autopsy series

Tester, D. J., Medeiros-Domingo, A., Will, M. L. & Ackerman, M. J., Oct 2011, In : Mayo Clinic proceedings. 86, 10, p. 941-947 7 p.

Research output: Contribution to journalArticle

54 Scopus citations
2010
13 Scopus citations

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

Kapplinger, J. D., Tester, D. J., Alders, M., Benito, B., Berthet, M., Brugada, J., Brugada, P., Fressart, V., Guerchicoff, A., Harris-Kerr, C., Kamakura, S., Kyndt, F., Koopmann, T. T., Miyamoto, Y., Pfeiffer, R., Pollevick, G. D., Probst, V., Zumhagen, S., Vatta, M., Towbin, J. A. & 9 others, Shimizu, W., Schulze-Bahr, E., Antzelevitch, C., Salisbury, B. A., Guicheney, P., Wilde, A. A. M., Brugada, R., Schott, J. J. & Ackerman, M. J., Jan 2010, In : Heart rhythm. 7, 1, p. 33-46 14 p.

Research output: Contribution to journalArticle

419 Scopus citations

A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy

Li, Z., Ai, T., Samani, K., Xi, Y., Tzeng, H. P., Xie, M., Wu, S., Ge, S., Taylor, M. D., Dong, J. W., Cheng, J., Ackerman, M. J., Kimura, A., Sinagra, G., Brunelli, L., Faulkner, G. & Vatta, M., Dec 1 2010, In : Circulation: Arrhythmia and Electrophysiology. 3, 6, p. 646-656 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Cardiac channel molecular autopsy for sudden unexpected death in epilepsy

Johnson, J. N., Tester, D. J., Bass, N. E. & Ackerman, M. J., Jul 2010, In : Journal of child neurology. 25, 7, p. 916-921 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Rubinshtein, R., Glockner, J. F., Ommen, S. R., Araoz, P. A., Ackerman, M. J., Sorajja, P., Bos, J. M., Tajik, A. J., Valeti, U. S., Nishimura, R. A. & Gersh, B. J., Jan 1 2010, In : Circulation: Heart Failure. 3, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

279 Scopus citations

Clinical Features and Outcome of Hypertrophic Cardiomyopathy Associated With Triple Sarcomere Protein Gene Mutations

Girolami, F., Ho, C. Y., Semsarian, C., Baldi, M., Will, M. L., Baldini, K., Torricelli, F., Yeates, L., Cecchi, F., Ackerman, M. J. & Olivotto, I., Apr 6 2010, In : Journal of the American College of Cardiology. 55, 14, p. 1444-1453 10 p.

Research output: Contribution to journalArticle

176 Scopus citations
56 Scopus citations

Epidemiologic, molecular, and functional evidence suggest A572D-SCN5A should not be considered an independent LQT3-susceptibility mutation

Tester, D. J., Valdivia, C., Harris-Kerr, C., Alders, M., Salisbury, B. A., Wilde, A. A. M., Makielski, J. C. & Ackerman, M. J., Jul 1 2010, In : Heart rhythm. 7, 7, p. 912-919 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Exercise extreme caution when calling rare genetic variants novel arrhythmia syndrome susceptibility mutations

Wilde, A. A. M. & Ackerman, M. J., Dec 2010, In : Heart rhythm. 7, 12, p. 1883-1885 3 p.

Research output: Contribution to journalEditorial

17 Scopus citations

Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K ATP channel Kir6.1 as a pathogenic substrate for J-wave syndromes

Medeiros-Domingo, A., Tan, B. H., Crotti, L., Tester, D. J., Eckhardt, L., Cuoretti, A., Kroboth, S. L., Song, C., Zhou, Q., Kopp, D., Schwartz, P. J., Makielski, J. C. & Ackerman, M. J., Oct 1 2010, In : Heart rhythm. 7, 10, p. 1466-1471 6 p.

Research output: Contribution to journalArticle

199 Scopus citations

Gene-specific paradoxical QT responses during rapid eye movement sleep in women with congenital long QT syndrome

Lanfranchi, P. A., Ackerman, M. J., Kara, T., Shamsuzzaman, A. S. M., Wolk, R., Jurak, P., Amin, R. & Somers, V. K., Sep 24 2010, In : Heart rhythm. 7, 8, p. 1067-1074 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetics and Genomics of Hypertrophic Cardiomyopathy

Martijn Bos, J., Ommen, S. R. & Ackerman, M. J., Dec 1 2010, Essentials of Genomic and Personalized Medicine. Elsevier Inc., p. 336-349 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetics of Heart Failure and Sudden Death

Vatta, M. & Ackerman, M. J., Oct 1 2010, In : Heart Failure Clinics. 6, 4, p. 507-514 8 p.

Research output: Contribution to journalReview article

3 Scopus citations

Genomic risk factors in sudden infant death syndrome

Van Norstrand, D. W. & Ackerman, M. J., Dec 1 2010, In : Genome medicine. 2, 11, 86.

Research output: Contribution to journalReview article

34 Scopus citations

Implantable cardioverter defibrillator therapy for congenital long QT syndrome: A single-center experience

Horner, J. M., Kinoshita, M., Webster, T. L., Haglund, C. M., Friedman, P. A. & Ackerman, M. J., Nov 1 2010, In : Heart rhythm. 7, 11, p. 1616-1622 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Loss-of-function mutation of the SCN3B-encoded sodium channel 3 subunit associated with a case of idiopathic ventricular fibrillation

Valdivia, C. R., Medeiros-Domingo, A., Ye, B., Shen, W. K., Algiers, T. J., Ackerman, M. J. & Makielski, J. C., Jun 1 2010, In : Cardiovascular research. 86, 3, p. 392-400 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Mutation-Specific Risk in Two Genetic Forms of Type 3 Long QT Syndrome

Liu, J. F., Moss, A. J., Jons, C., Benhorin, J., Schwartz, P. J., Spazzolini, C., Crotti, L., Ackerman, M. J., McNitt, S., Robinson, J. L., Qi, M., Goldenberg, I. & Zareba, W., Jan 15 2010, In : American Journal of Cardiology. 105, 2, p. 210-213 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mutation type is not clinically useful in predicting prognosis in hypertrophic cardiomyopathy

Landstrom, A. P. & Ackerman, M. J., Dec 7 2010, In : Circulation. 122, 23, p. 2441-2449 9 p.

Research output: Contribution to journalComment/debate

99 Scopus citations

Prevalence and spectrum of large deletions or duplications in the major long QT syndrome-susceptibility genes and implications for long QT syndrome genetic testing

Tester, D. J., Benton, A. J., Train, L., Deal, B., Baudhuin, L. M. & Ackerman, M. J., Oct 15 2010, In : American Journal of Cardiology. 106, 8, p. 1124-1128 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Prevention of torsade de pointes in hospital settings: A scientific statement from the American heart association and the American college of cardiology foundation

Drew, B. J., Ackerman, M. J., Funk, M., Gibler, W. B., Kligfield, P., Menon, V., Philippides, G. J., Roden, D. M. & Zareba, W., Mar 2010, In : Circulation. 121, 8, p. 1047-1060 14 p.

Research output: Contribution to journalReview article

288 Scopus citations
185 Scopus citations

Properties of WT and mutant hERG K+ channels expressed in neonatal mouse cardiomyocytes

Lin, E. C., Holzem, K. M., Anson, B. D., Moungey, B. M., Balijepalli, S. Y., Tester, D. J., Ackerman, M. J., Delisle, B. P., Balijepalli, R. C. & January, C. T., Jun 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 6, p. H1842-H1849

Research output: Contribution to journalArticle

13 Scopus citations

Response to Ho

Landstrom, A. P. & Ackerman, M. J., Dec 7 2010, In : Circulation. 122, 23, 1 p.

Research output: Contribution to journalComment/debate