Michael John Ackerman, MD, PhD, FACC

  • 35918 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2011

Risk of syncope in family members who are genotype-negative for a family-associated Long-QT syndrome mutation

Barsheshet, A., Moss, A. J., McNitt, S., Polonsky, S., Lopes, C. M., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Towbin, J. A., Vincent, G. M., Qi, M. & Goldenberg, I., Oct 2011, In : Circulation: Cardiovascular Genetics. 4, 5, p. 491-499 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Role of genetic testing for sudden death predisposing heart conditions in athletes

Landstrom, A. P., Tester, D. J. & Ackerman, M. J., 2011, Sports Cardiology Essentials: Evaluation, Management and Case Studies. Springer New York, p. 85-100 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Slow QT interval adaptation to heart rate changes in normal ambulatory subjects

Razak, E., Buncová, M., Shusterman, V., Winter, B., Shen, W. K., Ackerman, M. J., Donovan, T., Lampert, R. & Němec, J., Apr 2011, In : Annals of Noninvasive Electrocardiology. 16, 2, p. 148-155 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
18 Scopus citations

The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680h to increase late Na current

Cheng, J., Tester, D. J., Tan, B. H., Valdivia, C. R., Kroboth, S., Ye, B., January, C. T., Ackerman, M. J. & Makielski, J. C., May 2011, In : Physiological Genomics. 43, 9, p. 461-466 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

The diagnostic utility of recovery phase QTc during treadmill exercise stress testing in the evaluation of long QT syndrome

Horner, J. M., Horner, M. M. & Ackerman, M. J., Nov 2011, In : Heart Rhythm. 8, 11, p. 1698-1704 7 p.

Research output: Contribution to journalArticle

71 Scopus citations

Transient outward current (I to) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome

Giudicessi, J. R., Ye, D., Tester, D. J., Crotti, L., Mugione, A., Nesterenko, V. V., Albertson, R. M., Antzelevitch, C., Schwartz, P. J. & Ackerman, M. J., Jul 2011, In : Heart Rhythm. 8, 7, p. 1024-1032 9 p.

Research output: Contribution to journalArticle

165 Scopus citations

Unexplained drownings and the cardiac channelopathies: A molecular autopsy series

Tester, D. J., Medeiros-Domingo, A., Will, M. L. & Ackerman, M. J., 2011, In : Mayo Clinic Proceedings. 86, 10, p. 941-947 7 p.

Research output: Contribution to journalArticle

54 Scopus citations
2010
13 Scopus citations

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

Kapplinger, J. D., Tester, D. J., Alders, M., Benito, B., Berthet, M., Brugada, J., Brugada, P., Fressart, V., Guerchicoff, A., Harris-Kerr, C., Kamakura, S., Kyndt, F., Koopmann, T. T., Miyamoto, Y., Pfeiffer, R., Pollevick, G. D., Probst, V., Zumhagen, S., Vatta, M., Towbin, J. A. & 9 others, Shimizu, W., Schulze-Bahr, E., Antzelevitch, C., Salisbury, B. A., Guicheney, P., Wilde, A. A. M., Brugada, R., Schott, J. J. & Ackerman, M. J., Jan 2010, In : Heart Rhythm. 7, 1, p. 33-46 14 p.

Research output: Contribution to journalArticle

403 Scopus citations

A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy

Li, Z., Ai, T., Samani, K., Xi, Y., Tzeng, H. P., Xie, M., Wu, S., Ge, S., Taylor, M. D., Dong, J. W., Cheng, J., Ackerman, M. J., Kimura, A., Sinagra, G., Brunelli, L., Faulkner, G. & Vatta, M., Dec 2010, In : Circulation: Arrhythmia and Electrophysiology. 3, 6, p. 646-656 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cardiac channel molecular autopsy for sudden unexpected death in epilepsy

Johnson, J. N., Tester, D. J., Bass, N. E. & Ackerman, M. J., 2010, In : Journal of Child Neurology. 25, 7, p. 916-921 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Rubinshtein, R., Glockner, J., Ommen, S. R., Araoz, P. A., Ackerman, M. J., Sorajja, P., Bos, J. M., Tajik, A. J., Valeti, U. S., Nishimura, R. A. & Gersh, B. J., Jan 2010, In : Circulation: Heart Failure. 3, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

274 Scopus citations

Clinical Features and Outcome of Hypertrophic Cardiomyopathy Associated With Triple Sarcomere Protein Gene Mutations

Girolami, F., Ho, C. Y., Semsarian, C., Baldi, M., Will, M. L., Baldini, K., Torricelli, F., Yeates, L., Cecchi, F., Ackerman, M. J. & Olivotto, I., Apr 6 2010, In : Journal of the American College of Cardiology. 55, 14, p. 1444-1453 10 p.

Research output: Contribution to journalArticle

174 Scopus citations
55 Scopus citations

Epidemiologic, molecular, and functional evidence suggest A572D-SCN5A should not be considered an independent LQT3-susceptibility mutation

Tester, D. J., Valdivia, C., Harris-Kerr, C., Alders, M., Salisbury, B. A., Wilde, A. A. M., Makielski, J. C. & Ackerman, M. J., Jul 2010, In : Heart Rhythm. 7, 7, p. 912-919 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Exercise extreme caution when calling rare genetic variants novel arrhythmia syndrome susceptibility mutations

Wilde, A. A. M. & Ackerman, M. J., Dec 2010, In : Heart Rhythm. 7, 12, p. 1883-1885 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K ATP channel Kir6.1 as a pathogenic substrate for J-wave syndromes

Medeiros-Domingo, A., Tan, B. H., Crotti, L., Tester, D. J., Eckhardt, L., Cuoretti, A., Kroboth, S. L., Song, C., Zhou, Q., Kopp, D., Schwartz, P. J., Makielski, J. C. & Ackerman, M. J., Oct 2010, In : Heart Rhythm. 7, 10, p. 1466-1471 6 p.

Research output: Contribution to journalArticle

198 Scopus citations

Gene-specific paradoxical QT responses during rapid eye movement sleep in women with congenital long QT syndrome

Lanfranchi, P. A., Ackerman, M. J., Kara, T., Shamsuzzaman, A. S. M., Wolk, R., Jurak, P., Amin, R. & Somers, V., 2010, In : Heart Rhythm. 7, 8, p. 1067-1074 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetics and Genomics of Hypertrophic Cardiomyopathy

Martijn Bos, J., Ommen, S. R. & Ackerman, M. J., 2010, Essentials of Genomic and Personalized Medicine. Elsevier Inc., p. 336-349 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetics of Heart Failure and Sudden Death

Vatta, M. & Ackerman, M. J., Oct 2010, In : Heart Failure Clinics. 6, 4, p. 507-514 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Genomic risk factors in sudden infant death syndrome

Van Norstrand, D. W. & Ackerman, M. J., 2010, In : Genome Medicine. 2, 11, 86.

Research output: Contribution to journalArticle

34 Scopus citations

Implantable cardioverter defibrillator therapy for congenital long QT syndrome: A single-center experience

Horner, J. M., Kinoshita, M., Webster, T. L., Haglund, C. M., Friedman, P. A. & Ackerman, M. J., Nov 2010, In : Heart Rhythm. 7, 11, p. 1616-1622 7 p.

Research output: Contribution to journalArticle

65 Scopus citations

Loss-of-function mutation of the SCN3B-encoded sodium channel 3 subunit associated with a case of idiopathic ventricular fibrillation

Valdivia, C. R., Medeiros-Domingo, A., Ye, B., Shen, W. K., Algiers, T. J., Ackerman, M. J. & Makielski, J. C., Jun 2010, In : Cardiovascular Research. 86, 3, p. 392-400 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Mutation-Specific Risk in Two Genetic Forms of Type 3 Long QT Syndrome

Liu, J. F., Moss, A. J., Jons, C., Benhorin, J., Schwartz, P. J., Spazzolini, C., Crotti, L., Ackerman, M. J., McNitt, S., Robinson, J. L., Qi, M., Goldenberg, I. & Zareba, W., Jan 15 2010, In : American Journal of Cardiology. 105, 2, p. 210-213 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mutation type is not clinically useful in predicting prognosis in hypertrophic cardiomyopathy

Landstrom, A. P. & Ackerman, M. J., Dec 7 2010, In : Circulation. 122, 23, p. 2441-2449 9 p.

Research output: Contribution to journalArticle

96 Scopus citations

Prevalence and spectrum of large deletions or duplications in the major long QT syndrome-susceptibility genes and implications for long QT syndrome genetic testing

Tester, D. J., Benton, A. J., Train, L., Deal, B., Baudhuin, L. M. & Ackerman, M. J., Oct 15 2010, In : American Journal of Cardiology. 106, 8, p. 1124-1128 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Prevention of torsade de pointes in hospital settings: A scientific statement from the American heart association and the American college of cardiology foundation

Drew, B. J., Ackerman, M. J., Funk, M., Gibler, W. B., Kligfield, P., Menon, V., Philippides, G. J., Roden, D. M. & Zareba, W., Mar 2010, In : Circulation. 121, 8, p. 1047-1060 14 p.

Research output: Contribution to journalArticle

265 Scopus citations
171 Scopus citations

Properties of WT and mutant hERG K+ channels expressed in neonatal mouse cardiomyocytes

Lin, E. C., Holzem, K. M., Anson, B. D., Moungey, B. M., Balijepalli, S. Y., Tester, D. J., Ackerman, M. J., Delisle, B. P., Balijepalli, R. C. & January, C. T., Jun 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 6

Research output: Contribution to journalArticle

13 Scopus citations

Response to Ho

Landstrom, A. P. & Ackerman, M. J., Dec 7 2010, In : Circulation. 122, 23, p. 2440 1 p.

Research output: Contribution to journalArticle

Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals

Goldenberg, I., Horr, S., Moss, A. J., Lopes, C. M., Barsheshet, A., McNitt, S., Zareba, W., Andrews, M. L., Robinson, J. L., Locati, E. H., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Napolitano, C., Platonov, P. G., Priori, S. G., Qi, M., Schwartz, P. J., Shimizu, W., Towbin, J. A. & 3 others, Vincent, G. M., Wilde, A. A. M. & Zhang, L., Dec 28 2010, In : Journal of the American College of Cardiology. 57, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

164 Scopus citations

Role of family history of sudden death in risk stratification and prevention of sudden death with implantable defibrillators in hypertrophic cardiomyopathy

Bos, J. M., Maron, B. J., Ackerman, M. J., Haas, T. S., Sorajja, P., Nishimura, R. A., Gersh, B. J. & Ommen, S. R., Nov 15 2010, In : American Journal of Cardiology. 106, 10, p. 1481-1486 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

SCN5A allelic expression imbalance in African-Americans heterozygous for the common variant p.Ser1103Tyr

Killen, S. A. S., Kunic, J., Wang, L., Lewis, A., Levy, B. P., Ackerman, M. J. & George, A. L., May 14 2010, In : BMC Medical Genetics. 11, 1, 74.

Research output: Contribution to journalArticle

7 Scopus citations

Sudden infant death syndrome-associated mutations in the sodium channel beta subunits

Tan, B. H., Pundi, K. N., Van Norstrand, D. W., Valdivia, C. R., Tester, D. J., Medeiros-Domingo, A., Makielski, J. C. & Ackerman, M. J., Jun 2010, In : Heart Rhythm. 7, 6, p. 771-778 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

The prevalence and diagnostic/prognostic utility of sinus arrhythmia in the evaluation of congenital long QT syndrome

Johnson, J. N. & Ackerman, M. J., Dec 2010, In : Heart Rhythm. 7, 12, p. 1785-1789 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Transient QT interval prolongation in an infant with Simpson-Golabi-Behmel syndrome

Gertsch, E., Kirmani, S., Ackerman, M. J. & Babovic-Vuksanovic, D., Sep 2010, In : American Journal of Medical Genetics, Part A. 152, 9, p. 2379-2382 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Trigger-specific risk factors and response to therapy in long QT syndrome type 2

Kim, J. A., Lopes, C. M., Moss, A. J., McNitt, S., Barsheshet, A., Robinson, J. L., Zareba, W., Ackerman, M. J., Kaufman, E. S., Towbin, J. A., Vincent, M. & Goldenberg, I., Dec 2010, In : Heart Rhythm. 7, 12, p. 1797-1805 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Z-Disc Genes in Hypertrophic Cardiomyopathy. Stretching the Cardiomyopathies?

Bos, J. M. & Ackerman, M. J., Mar 16 2010, In : Journal of the American College of Cardiology. 55, 11, p. 1136-1138 3 p.

Research output: Contribution to journalArticle

25 Scopus citations
2009

A functional and structural study of tropon in C mutations related to hypertrophic cardiomyopathy

Pinto, J. R., Parvatiyar, M. S., Jones, M. A., Liang, J., Ackerman, M. J. & Potter, J. D., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19090-19100 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Cardiac Ankyrin Repeat Protein Gene (ANKRD1) Mutations in Hypertrophic Cardiomyopathy

Arimura, T., Bos, J. M., Sato, A., Kubo, T., Okamoto, H., Nishi, H., Harada, H., Koga, Y., Moulik, M., Doi, Y. L., Towbin, J. A., Ackerman, M. J. & Kimura, A., Jul 21 2009, In : Journal of the American College of Cardiology. 54, 4, p. 334-342 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Cardiomyopathic and channelopathic causes of sudden unexplained death in infants and children

Tester, D. J. & Ackerman, M. J., 2009, In : Annual Review of Medicine. 60, p. 69-84 16 p.

Research output: Contribution to journalArticle

87 Scopus citations

Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy

Spazzolini, C., Mullally, J., Moss, A. J., Schwartz, P. J., McNitt, S., Ouellet, G., Fugate, T., Goldenberg, I., Jons, C., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Crotti, L., Kaufman, E. S., Locati, E. H., Qi, M., Napolitano, C., Priori, S. G., Towbin, J. A. & 1 others, Vincent, G. M., Aug 25 2009, In : Journal of the American College of Cardiology. 54, 9, p. 832-837 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Device complications and inappropriate implantable cardioverter defibrillator shocks in patients with hypertrophic cardiomyopathy

Lin, G. D., Nishimura, R. A., Gersh, B. J., Phil, D., Ommen, S. R., Ackerman, M. J. & Brady, P. A., May 2009, In : Heart. 95, 9, p. 709-714 6 p.

Research output: Contribution to journalArticle

98 Scopus citations

Diagnostic, Prognostic, and Therapeutic Implications of Genetic Testing for Hypertrophic Cardiomyopathy

Bos, J. M., Towbin, J. A. & Ackerman, M. J., Jul 14 2009, In : Journal of the American College of Cardiology. 54, 3, p. 201-211 11 p.

Research output: Contribution to journalArticle

240 Scopus citations

Diastolic Dysfunction and Its Histopathological Correlation in Obstructive Hypertrophic Cardiomyopathy in Children and Adolescents

Menon, S. C., Eidem, B. W., Dearani, J. A., Ommen, S. R., Ackerman, M. J. & Miller, D., Dec 2009, In : Journal of the American Society of Echocardiography. 22, 12, p. 1327-1334 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Expression patterns of cardiac myofilament proteins

Theis, J. L., Bos, J. M., Theis, J. D., Miller, D. V., Dearani, J. A., Schaff, H. V., Gersh, B. J., Ommen, S. R., Moss, R. L. & Ackerman, M. J., Jul 2009, In : Circulation: Heart Failure. 2, 4, p. 325-333 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic testing for long-qt syndrome: Distinguishing pathogenic mutations from benign variants

Kapa, S., Tester, D. J., Salisbury, B. A., Harris-Kerr, C., Pungliya, M. S., Alders, M., Wilde, A. A. M. & Ackerman, M. J., Nov 2009, In : Circulation. 120, 18, p. 1752-1760 9 p.

Research output: Contribution to journalArticle

242 Scopus citations

Genotype-Phenotype Aspects of Type 2 Long QT Syndrome

Shimizu, W., Moss, A. J., Wilde, A. A. M., Towbin, J. A., Ackerman, M. J., January, C. T., Tester, D. J., Zareba, W., Robinson, J. L., Qi, M., Vincent, G. M., Kaufman, E. S., Hofman, N., Noda, T., Kamakura, S., Miyamoto, Y., Shah, S., Amin, V., Goldenberg, I., Andrews, M. L. & 1 others, McNitt, S., Nov 24 2009, In : Journal of the American College of Cardiology. 54, 22, p. 2052-2062 11 p.

Research output: Contribution to journalArticle

168 Scopus citations
74 Scopus citations