Michael John Ackerman, MD, PhD, FACC

  • 37409 Citations
  • 106 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2010

Sudden infant death syndrome-associated mutations in the sodium channel beta subunits

Tan, B. H., Pundi, K. N., Van Norstrand, D. W., Valdivia, C. R., Tester, D. J., Medeiros-Domingo, A., Makielski, J. C. & Ackerman, M. J., Jun 1 2010, In : Heart rhythm. 7, 6, p. 771-778 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

The prevalence and diagnostic/prognostic utility of sinus arrhythmia in the evaluation of congenital long QT syndrome

Johnson, J. N. & Ackerman, M. J., Dec 1 2010, In : Heart rhythm. 7, 12, p. 1785-1789 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Transient QT interval prolongation in an infant with Simpson-Golabi-Behmel syndrome

Gertsch, E., Kirmani, S., Ackerman, M. J. & Babovic-Vuksanovic, D., Sep 1 2010, In : American Journal of Medical Genetics, Part A. 152, 9, p. 2379-2382 4 p.

Research output: Contribution to journalLetter

7 Scopus citations

Trigger-specific risk factors and response to therapy in long QT syndrome type 2

Kim, J. A., Lopes, C. M., Moss, A. J., McNitt, S., Barsheshet, A., Robinson, J. L., Zareba, W., Ackerman, M. J., Kaufman, E. S., Towbin, J. A., Vincent, M. & Goldenberg, I., Dec 1 2010, In : Heart rhythm. 7, 12, p. 1797-1805 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Z-Disc Genes in Hypertrophic Cardiomyopathy. Stretching the Cardiomyopathies?

Bos, J. M. & Ackerman, M. J., Mar 16 2010, In : Journal of the American College of Cardiology. 55, 11, p. 1136-1138 3 p.

Research output: Contribution to journalEditorial

26 Scopus citations
2009

A functional and structural study of tropon in C mutations related to hypertrophic cardiomyopathy

Pinto, J. R., Parvatiyar, M. S., Jones, M. A., Liang, J., Ackerman, M. J. & Potter, J. D., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19090-19100 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

Cardiac Ankyrin Repeat Protein Gene (ANKRD1) Mutations in Hypertrophic Cardiomyopathy

Arimura, T., Bos, J. M., Sato, A., Kubo, T., Okamoto, H., Nishi, H., Harada, H., Koga, Y., Moulik, M., Doi, Y. L., Towbin, J. A., Ackerman, M. J. & Kimura, A., Jul 21 2009, In : Journal of the American College of Cardiology. 54, 4, p. 334-342 9 p.

Research output: Contribution to journalArticle

106 Scopus citations

Cardiomyopathic and channelopathic causes of sudden unexplained death in infants and children

Tester, D. J. & Ackerman, M. J., Jul 24 2009, In : Annual Review of Medicine. 60, p. 69-84 16 p.

Research output: Contribution to journalReview article

87 Scopus citations

Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy

Spazzolini, C., Mullally, J., Moss, A. J., Schwartz, P. J., McNitt, S., Ouellet, G., Fugate, T., Goldenberg, I., Jons, C., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Crotti, L., Kaufman, E. S., Locati, E. H., Qi, M., Napolitano, C., Priori, S. G., Towbin, J. A. & 1 others, Vincent, G. M., Aug 25 2009, In : Journal of the American College of Cardiology. 54, 9, p. 832-837 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Device complications and inappropriate implantable cardioverter defibrillator shocks in patients with hypertrophic cardiomyopathy

Lin, G., Nishimura, R. A., Gersh, B. J., Phil, D., Ommen, S. R., Ackerman, M. J. & Brady, P. A., May 1 2009, In : Heart. 95, 9, p. 709-714 6 p.

Research output: Contribution to journalArticle

100 Scopus citations

Diagnostic, Prognostic, and Therapeutic Implications of Genetic Testing for Hypertrophic Cardiomyopathy

Bos, J. M., Towbin, J. A. & Ackerman, M. J., Jul 14 2009, In : Journal of the American College of Cardiology. 54, 3, p. 201-211 11 p.

Research output: Contribution to journalReview article

243 Scopus citations

Diastolic Dysfunction and Its Histopathological Correlation in Obstructive Hypertrophic Cardiomyopathy in Children and Adolescents

Menon, S. C., Eidem, B. W., Dearani, J. A., Ommen, S. R., Ackerman, M. J. & Miller, D., Dec 2009, In : Journal of the American Society of Echocardiography. 22, 12, p. 1327-1334 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Expression patterns of cardiac myofilament proteins

Theis, J. L., Bos, J. M., Theis, J. D., Miller, D. V., Dearani, J. A., Schaff, H. V., Gersh, B. J., Ommen, S. R., Moss, R. L. & Ackerman, M. J., Jul 1 2009, In : Circulation: Heart Failure. 2, 4, p. 325-333 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Genetic testing for long-qt syndrome: Distinguishing pathogenic mutations from benign variants

Kapa, S., Tester, D. J., Salisbury, B. A., Harris-Kerr, C., Pungliya, M. S., Alders, M., Wilde, A. A. M. & Ackerman, M. J., Nov 1 2009, In : Circulation. 120, 18, p. 1752-1760 9 p.

Research output: Contribution to journalArticle

248 Scopus citations

Genotype-Phenotype Aspects of Type 2 Long QT Syndrome

Shimizu, W., Moss, A. J., Wilde, A. A. M., Towbin, J. A., Ackerman, M. J., January, C. T., Tester, D. J., Zareba, W., Robinson, J. L., Qi, M., Vincent, G. M., Kaufman, E. S., Hofman, N., Noda, T., Kamakura, S., Miyamoto, Y., Shah, S., Amin, V., Goldenberg, I., Andrews, M. L. & 1 others, McNitt, S., Nov 24 2009, In : Journal of the American College of Cardiology. 54, 22, p. 2052-2062 11 p.

Research output: Contribution to journalArticle

172 Scopus citations

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A

Valdivia, C. R., Ueda, K., Ackerman, M. J. & Makielski, J. C., Oct 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 4, p. H1446-H1452

Research output: Contribution to journalArticle

76 Scopus citations

GWAS or Gee Whiz, PSAS or Pshaw: Elucidating the biologic and clinical significance of genetic variation in cardiovascular disease

Landstrom, A. P. & Ackerman, M. J., Dec 1 2009, In : Heart rhythm. 6, 12, p. 1751-1753 3 p.

Research output: Contribution to journalEditorial

5 Scopus citations

Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations

McLeod, C. J., Bos, J. M., Theis, J. L., Edwards, W. D., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., Nov 1 2009, In : American heart journal. 158, 5, p. 799-805 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hypertrophic Cardiomyopathy in the Era of Genomic Medicine

Bos, J. M., Ommen, S. R. & Ackerman, M. J., Dec 1 2009, Genomic and Personalized Medicine, Two-Vol Set. Elsevier Inc., p. 716-728 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy

Johnson, J. N., Hofman, N., Haglund, C. M., Cascino, G. D., Wilde, A. A. M. & Ackerman, M. J., Jan 20 2009, In : Neurology. 72, 3, p. 224-231 8 p.

Research output: Contribution to journalArticle

170 Scopus citations

Left cardiac sympathetic denervation for the treatment of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia using video-assisted thoracic surgery

Collura, C. A., Johnson, J. N., Moir, C. & Ackerman, M. J., Jun 1 2009, In : Heart rhythm. 6, 6, p. 752-759 8 p.

Research output: Contribution to journalArticle

231 Scopus citations

Long QT syndrome due to a novel mutation in SCN5A: Treatment with ICD placement at 1 month and left cardiac sympathetic denervation at 3 months of age

Silver, E. S., Liberman, L., Chung, W. K., Spotnitz, H. M., Chen, J. M., Ackerman, M. J., Moir, C., Hordof, A. J. & Pass, R. H., Oct 1 2009, In : Journal of Interventional Cardiac Electrophysiology. 26, 1, p. 41-45 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Molecular evolution of the junctophilin gene family

Garbino, A., Van Oort, R. J., Dixit, S. S., Landstrom, A. P., Ackerman, M. J. & Wehrens, X. H. T., May 2009, In : Physiological Genomics. 37, 3, p. 175-186 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome

Jons, C., Moss, A. J., Lopes, C. M., McNitt, S., Zareba, W., Goldenberg, I., Qi, M., Wilde, A. A. M., Shimizu, W., Kanters, J. K., Towbin, J. A., Ackerman, M. J. & Robinson, J. L., Aug 1 2009, In : Journal of cardiovascular electrophysiology. 20, 8, p. 859-865 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
17 Scopus citations

Outcome of Patients With Hypertrophic Cardiomyopathy and a Normal Electrocardiogram

McLeod, C. J., Ackerman, M. J., Nishimura, R. A., Tajik, A. J., Gersh, B. J. & Ommen, S. R., Jul 14 2009, In : Journal of the American College of Cardiology. 54, 3, p. 229-233 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

Protein kinase a-Dependent biophysical phenotype for V227F-KCNJ2 mutation in catecholaminergic polymorphic ventricular tachycardia

Makielski, J. C., Vega, A. L., Tester, D. J. & Ackerman, M. J., Oct 1 2009, In : Circulation: Arrhythmia and Electrophysiology. 2, 5, p. 540-547 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

QTc: How long is too long?

Johnson, J. N. & Ackerman, M. J., Sep 1 2009, In : British journal of sports medicine. 43, 9, p. 657-662 6 p.

Research output: Contribution to journalReview article

124 Scopus citations

QT interval variability and adaptation to heart rate changes in patients with long QT syndrome

Němec, J., Buncová, M., Shusterman, V., Winter, B., Shen, W. K. & Ackerman, M. J., Jan 1 2009, In : PACE - Pacing and Clinical Electrophysiology. 32, 1, p. 72-81 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Response to Elliott and McKenna

Maron, B. J., Seidman, C. E., Ackerman, M. J., Towbin, J. A., Maron, M. S., Ommen, S. R., Nishimura, R. A. & Gersh, B. J., Feb 1 2009, In : Circulation: Cardiovascular Genetics. 2, 1, 1 p.

Research output: Contribution to journalComment/debate

Response to letter regarding article, prevalence, clinical significance, and natural history of left ventricular apical aneurysms in hypertrophic cardiomyopathy

Maron, M. S., Finley, J. J., Udelson, J. E., Bos, J. M., Ackerman, M. J., Hauser, T. H., Manning, W. J., Haas, T. S., Lesser, J. R. & Maron, B. J., Jun 9 2009, In : Circulation. 119, 22, p. e558

Research output: Contribution to journalLetter

Sodium channel mutation in irritable bowel syndrome: Evidence for an ion channelopathy

Saito, Y. A., Strege, P. R., Tester, D. J., Locke, G. R., Talley, N. J., Bernard, C. E., Rae, J. L., Makielski, J. C., Ackerman, M. J. & Farrugia, G., Feb 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 2, p. G211-G218

Research output: Contribution to journalArticle

86 Scopus citations

Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION® long QT syndrome genetic test

Kapplinger, J. D., Tester, D. J., Salisbury, B. A., Carr, J. L., Harris-Kerr, C., Pollevick, G. D., Wilde, A. A. M. & Ackerman, M. J., Sep 2009, In : Heart rhythm. 6, 9, p. 1297-1303 7 p.

Research output: Contribution to journalArticle

263 Scopus citations
47 Scopus citations

Subacute perforation of the st. jude riata implantable cardioverter- defibrillator lead: A report of two pediatric cases

Morrison, T. B., Ackerman, M. J. & Rea, R. F., Aug 1 2009, In : Pediatric Cardiology. 30, 6, p. 834-836 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Sudden infant death syndrome: Do ion channels play a role?

Van Norstrand, D. W. & Ackerman, M. J., Feb 1 2009, In : Heart rhythm. 6, 2, p. 272-278 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome. A Comprehensive Open Reading Frame Mutational Analysis

Medeiros-Domingo, A., Bhuiyan, Z. A., Tester, D. J., Hofman, N., Bikker, H., van Tintelen, J. P., Mannens, M. M. A. M., Wilde, A. A. M. & Ackerman, M. J., Nov 24 2009, In : Journal of the American College of Cardiology. 54, 22, p. 2065-2074 10 p.

Research output: Contribution to journalArticle

196 Scopus citations

Unique mixed phenotype and unexpected functional effect revealed by novel compound heterozygosity mutations involving SCN5A

Medeiros-Domingo, A., Tan, B. H., Iturralde-Torres, P., Tester, D. J., Tusié-Luna, T., Makielski, J. C. & Ackerman, M. J., Aug 1 2009, In : Heart rhythm. 6, 8, p. 1170-1175 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

What's in a name? Dilemmas in nomenclature characterizing hypertrophic cardiomyopathy and left ventricular hypertrophy

Maron, B. J., Seidman, C. E., Ackerman, M. J., Towbin, J. A., Maron, M. S., Ommen, S. R., Nishimura, R. A. & Gersh, B. J., Feb 1 2009, In : Circulation: Cardiovascular Genetics. 2, 1, p. 81-85 5 p.

Research output: Contribution to journalComment/debate

42 Scopus citations

α1-Syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current

Ackerman, M. J., Cheng, J., Van Norstrand, D. W., Medeiros-Domingo, A., Valdivia, C., Tan, B. H., Ye, B., Kroboth, S., Vatta, M., Tester, D. J., January, C. T. & Makielski, J. C., Dec 1 2009, In : Circulation: Arrhythmia and Electrophysiology. 2, 6, p. 667-676 10 p.

Research output: Contribution to journalArticle

64 Scopus citations
2008

alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption.

Wu, G., Ai, T., Kim, J. J., Mohapatra, B., Xi, Y., Li, Z., Abbasi, S., Purevjav, E., Samani, K., Ackerman, M. J., Qi, M., Moss, A. J., Shimizu, W., Towbin, J. A., Cheng, J. & Vatta, M., Aug 2008, In : Circulation. Arrhythmia and electrophysiology. 1, 3, p. 193-201 9 p.

Research output: Contribution to journalArticle

94 Scopus citations

A mutation in telethonin alters Nav1.5 function

Mazzone, A., Strege, P. R., Tester, D. J., Bernard, C. E., Faulkner, G., De Giorgio, R., Makielski, J. C., Stanghellini, V., Gibbons, S. J., Ackerman, M. J. & Farrugia, G., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16537-16544 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

A mutation in telethonin alters Nav1.5 function (Journal of Biological Chemistry (2008) 283 (16537-16544))

Mazzone, A., Strege, P. R., Tester, D. J., Bernard, C. E., Faulkner, G., De Giorgio, R., Makielski, J. C., Stanghellini, V., Gibbons, S. J., Ackerman, M. J. & Farrugia, G., Aug 8 2008, In : Journal of Biological Chemistry. 283, 32, 1 p.

Research output: Contribution to journalComment/debate

Arrhythmogenic malignancies in hypertrophic cardiomyopathy

Menon, S. C., Bos, J. M., Ommen, S. R. & Ackerman, M. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 610-626 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome

Gong, Q., Zhang, L., Moss, A. J., Vincent, G. M., Ackerman, M. J., Robinson, J. C., Jones, M. A., Tester, D. J. & Zhou, Z., Mar 1 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 502-509 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Congenital long QT syndrome

Ackerman, M. J., Khositseth, A., Tester, D. J. & Schwartz, P. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 462-482 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms

Chen, Z., Huang, W., Dahme, T., Rottbauer, W., Ackerman, M. J. & Xu, X., Jul 1 2008, In : Cardiovascular research. 79, 1, p. 97-108 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Electrical diseases of the heart: Genetics, mechanisms, treatment, prevention

Gussak, I., Antzelevitch, C., Wilde, A. A. M., Friedman, P. A., Ackerman, M. J. & Shen, W. K., Dec 1 2008, Springer London. 968 p.

Research output: Book/ReportBook

12 Scopus citations

Genetic testing

Tester, D. J. & Ackerman, M. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 444-458 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Impact of Septal Myectomy on Left Atrial Volume and Left Ventricular Diastolic Filling Patterns: An Echocardiographic Study of Young Patients with Obstructive Hypertrophic Cardiomyopathy

Menon, S. C., Ackerman, M. J., Ommen, S. R., Cabalka, A. K., Hagler, D. J., O'Leary, P. W., Dearani, J. A., Cetta, F. & Eidem, B. W., Jun 1 2008, In : Journal of the American Society of Echocardiography. 21, 6, p. 684-688 5 p.

Research output: Contribution to journalArticle

25 Scopus citations