Michael John Ackerman, MD, PhD, FACC

  • 35999 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2018

2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., Gillis, A. M., Granger, C. B., Hammill, S. C., Hlatky, M. A., Joglar, J. A., Kay, G. N., Matlock, D. D., Myerburg, R. J. & Page, R. L., Oct 2 2018, In : Journal of the American College of Cardiology. 72, 14, p. e91-e220

Research output: Contribution to journalArticle

117 Scopus citations

Adaptation and validation of the ACMG/AMP variant classification framework for MYH7-associated inherited cardiomyopathies: Recommendations by ClinGen's Inherited Cardiomyopathy Expert Panel

ClinGen Cardiovascular Clinical Domain Working Group, Mar 1 2018, In : Genetics in Medicine. 20, 3, p. 351-359 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis

Chatterjee, D., Fatah, M., Akdis, D., Spears, D. A., Koopmann, T. T., Mittal, K., Rafiq, M. A., Cattanach, B. M., Zhao, Q., Healey, J. S., Ackerman, M. J., Bos, J. M., Sun, Y., Maynes, J. T., Brunckhorst, C., Medeiros-Domingo, A., Duru, F., Saguner, A. M. & Hamilton, R. M., Nov 21 2018, In : European Heart Journal. 39, 44, p. 3932-3944 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Beyond the length and look of repolarization: Defining the non-QTc electrocardiographic profiles of patients with congenital long QT syndrome

Lane, C. M., Bos, J. M., Rohatgi, R. K. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

2 Scopus citations

Cardiac Genetic Predisposition in Sudden Infant Death Syndrome

Tester, D. J., Wong, L. C. H., Chanana, P., Jaye, A., Evans, J. M., FitzPatrick, D. R., Evans, M. J., Fleming, P., Jeffrey, I., Cohen, M. C., Tfelt-Hansen, J., Simpson, M. A., Behr, E. R. & Ackerman, M. J., Mar 20 2018, In : Journal of the American College of Cardiology. 71, 11, p. 1217-1227 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cardiovascular safety of prokinetic agents: A focus on drug-induced arrhythmias

Giudicessi, J. R., Ackerman, M. J. & Camilleri, M., Jun 1 2018, In : Neurogastroenterology and Motility. 30, 6, e13302.

Research output: Contribution to journalReview article

11 Scopus citations

Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing

Giudicessi, J. R., Roden, D. M., Wilde, A. A. M. & Ackerman, M. J., Feb 6 2018, In : Circulation. 137, 6, p. 619-630 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Clinical Significance of Early Repolarization in Long QT Syndrome

Sugrue, A., Rohatgi, R. K., Bos, M., Vaidya, V. R., Asirvatham, S. J., Noseworthy, P. & Ackerman, M. J., Sep 1 2018, In : JACC: Clinical Electrophysiology. 4, 9, p. 1238-1244 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Common Phenotype in Patients With Mitral Valve Prolapse Who Experienced Sudden Cardiac Death

Hourdain, J., Clavel, M. A., Deharo, J. C., Asirvatham, S. J., Avierinos, J. F., Habib, G., Franceschi, F., Probst, V., Sadoul, N., Martins, R., Leclercq, C., Chauvin, M., Pasquie, J. L., Maury, P., Laurent, G., Ackerman, M. J., Hodge, D. O. & Sarano, M. E., Sep 4 2018, In : Circulation. 138, 10, p. 1067-1069 3 p.

Research output: Contribution to journalLetter

3 Scopus citations

Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study

Männikkö, R., Wong, L., Tester, D. J., Thor, M. G., Sud, R., Kullmann, D. M., Sweeney, M. G., Leu, C., Sisodiya, S. M., FitzPatrick, D. R., Evans, M. J., Jeffrey, I. J. M., Tfelt-Hansen, J., Cohen, M. C., Fleming, P. J., Jaye, A., Simpson, M. A., Ackerman, M. J., Hanna, M. G., Behr, E. R. & 1 others, Matthews, E., Apr 14 2018, In : The Lancet. 391, 10129, p. 1483-1492 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Effect of Ascertainment Bias on Estimates of Patient Mortality in Inherited Cardiac Diseases

Nannenberg, E. A., van Rijsingen, I. A. W., van der Zwaag, P. A., van den Berg, M. P., van Tintelen, J. P., Tanck, M. W. T., Ackerman, M. J., Wilde, A. A. M. & Christiaans, I., Oct 1 2018, In : Circulation. Genomic and precision medicine. 11, 10, p. e001797

Research output: Contribution to journalArticle

2 Scopus citations

Effect of Body Mass Index on Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

Larsen, C. M., Ball, C. A., Hebl, V. B., Ong, K. C., Siontis, K. C., Olson, T. P., Ackerman, M. J., Ommen, S. R., Allison, T. G. & Geske, J. B., Jan 1 2018, In : American Journal of Cardiology. 121, 1, p. 100-106 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Exome-Wide Rare Variant Analyses in Sudden Infant Death Syndrome

Tester, D. J., Wong, L. C. H., Chanana, P., Gray, B., Jaye, A., Evans, J. M., Evans, M., Fleming, P., Jeffrey, I., Cohen, M., Tfelt-Hansen, J., Simpson, M. A., Behr, E. R. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : Journal of Pediatrics.

Research output: Contribution to journalArticle

3 Scopus citations

Functional Invalidation of Putative Sudden Infant Death Syndrome-Associated Variants in the KCNH2-Encoded Kv11.1 Channel

Smith, J. L., Tester, D. J., Hall, A. R., Burgess, D. E., Hsu, C. C., Elayi, S. C., Anderson, C. L., January, C. T., Luo, J. Z., Hartzel, D. N., Mirshahi, U. L., Murray, M. F., Mirshahi, T., Ackerman, M. J. & Delisle, B. P., May 1 2018, In : Circulation. Arrhythmia and electrophysiology. 11, 5, p. e005859

Research output: Contribution to journalArticle

1 Scopus citations

Genetic testing in athletes

Tester, D. J. & Ackerman, M. J., Apr 20 2018, Exercise Risks, Cardiac Arrhythmias and Unusual Problems in Athletes. World Scientific Publishing Co. Pte Ltd, Vol. 3-3. p. 41-74 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Idiopathic Restrictive Cardiomyopathy in Children and Young Adults

Anderson, H. N., Cetta, F., Driscoll, D. J., Olson, T. M., Ackerman, M. J. & Johnson, J. N., Jan 1 2018, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

2 Scopus citations

Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: A systematic review

Roston, T. M., Jones, K., Hawkins, N. M., Bos, J. M., Schwartz, P. J., Perry, F., Ackerman, M. J., Laksman, Z. W. M., Kaul, P., Lieve, K. V. V., Atallah, J., Krahn, A. D. & Sanatani, S., Dec 1 2018, In : Heart Rhythm. 15, 12, p. 1791-1799 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Importance of Variant Interpretation in Whole-Exome Molecular Autopsy: Population-Based Case Series

Shanks, G. W., Tester, D. J., Ackerman, J. P., Simpson, M. A., Behr, E. R., White, S. M. & Ackerman, M. J., Jun 19 2018, In : Circulation. 137, 25, p. 2705-2715 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

International recommendations for electrocardiographic interpretation in athletes

Sharma, S., Drezner, J. A., Baggish, A., Papadakis, M., Wilson, M. G., Prutkin, J. M., La Gerche, A., Ackerman, M. J., Borjesson, M., Salerno, J. C., Asif, I. M., Owens, D. S., Chung, E. H., Emery, M. S., Froelicher, V. F., Heidbuchel, H., Adamuz, C., Asplund, C. A., Cohen, G., Harmon, K. G. & 13 others, Marek, J. C., Molossi, S., Niebauer, J., Pelto, H. F., Perez, M. V., Riding, N. R., Saarel, T., Schmied, C. M., Shipon, D. M., Stein, R., Vetter, V. L., Pelliccia, A. & Corrado, D., Apr 21 2018, In : European Heart Journal. 39, 16, p. 1466-1480 15 p.

Research output: Contribution to journalArticle

59 Scopus citations

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Nav1.5 current and mechanosensitivity

Strege, P. R., Mazzone, A., Bernard, C. E., Neshatian, L., Gibbons, S. J., Saito Loftus, Y. A., Tester, D. J., Calvert, M. L., Mayer, E. A., Chang, L., Ackerman, M. J., Beyder, A. & Farrugia, G., Apr 1 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 4, p. G494-G503

Research output: Contribution to journalArticle

9 Scopus citations

Left axis deviation in children without previously known heart disease

Schneider, A. E., Cannon, B. C., Johnson, J. N., Ackerman, M. J. & Wackel, P. L., Mar 1 2018, In : Pediatrics. 141, 3, e20171970.

Research output: Contribution to journalArticle

1 Scopus citations

Left Ventricular Isovolumetric Relaxation Time Is Prolonged in Fetal Long-QT Syndrome

Clur, S. A. B., Vink, A. S., Etheridge, S. P., Robles De Medina, P. G., Rydberg, A., Ackerman, M. J., Wilde, A. A., Blom, N. A., Benson, D. W., Herberg, U., Donofrio, M. T. & Cuneo, B. F., Apr 1 2018, In : Circulation: Arrhythmia and Electrophysiology. 11, 4, e005797.

Research output: Contribution to journalArticle

1 Scopus citations

Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart

Jones, D. K., Johnson, A. C., Roti, E. C. R., Liu, F., Uelmen, R., Ayers, R. A., Baczko, I., Tester, D. J., Ackerman, M. J., Trudeau, M. C. & Robertson, G. A., Mar 1 2018, In : Journal of Cell Science. 131, 6, jcs206730.

Research output: Contribution to journalArticle

3 Scopus citations

Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death

Haïssaguerre, M., Hocini, M., Cheniti, G., Duchateau, J., Sacher, F., Puyo, S., Cochet, H., Takigawa, M., Denis, A., Martin, R., Derval, N., Bordachar, P., Ritter, P., Ploux, S., Pambrun, T., Klotz, N., Massoullié, G., Pillois, X., Dallet, C., Schott, J. J. & 19 others, Scouarnec, S., Ackerman, M. J., Tester, D., Piot, O., Pasquié, J. L., Leclerc, C., Hermida, J. S., Gandjbakhch, E., Maury, P., Labrousse, L., Coronel, R., Jais, P., Benoist, D., Vigmond, E., Potse, M., Walton, R., Nademanee, K., Bernus, O. & Dubois, R., Jul 1 2018, In : Circulation: Arrhythmia and Electrophysiology. 11, 7, e006120.

Research output: Contribution to journalArticle

11 Scopus citations

Long QT syndrome type 5-Lite: Defining the clinical phenotype associated with the potentially proarrhythmic p.Asp85Asn-KCNE1 common genetic variant

Lane, C. M., Giudicessi, J. R., Ye, D., Tester, D. J., Rohatgi, R. K., Bos, J. M. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

5 Scopus citations

Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5a mutation, N406K, found in LQT3 patients

Hu, R. M., Tester, D. J., Li, R., Sun, T., Peterson, B. Z., Ackerman, M. J., Makielski, J. C. & Tan, B. H., Jan 1 2018, In : Channels. 12, 1, p. 176-186 11 p.

Research output: Contribution to journalArticle

Noncardiac genetic predisposition in sudden infant death syndrome

Gray, B., Tester, D. J., Wong, L. C., Chanana, P., Jaye, A., Evans, J. M., Baruteau, A. E., Evans, M., Fleming, P., Jeffrey, I., Cohen, M., Tfelt-Hansen, J., Simpson, M. A., Ackerman, M. J. & Behr, E. R., Jan 1 2018, (Accepted/In press) In : Genetics in Medicine.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

Perioperative management of patients with congenital or acquired disorders of the QT interval

O'Hare, M., Maldonado, Y., Munro, J., Ackerman, M. J., Ramakrishna, H. & Sorajja, D., Apr 1 2018, In : British Journal of Anaesthesia. 120, 4, p. 629-644 16 p.

Research output: Contribution to journalReview article

2 Scopus citations

Platelet Function Analyzer 100 and Brain Natriuretic Peptide as Biomarkers in Obstructive Hypertrophic Cardiomyopathy

Blackshear, J. L., Safford, R. E., Thomas, C. S., Bos, J. M., Ackerman, M. J., Geske, J. B., Ommen, S. R., Shapiro, B. P. & Johns, G. S., Mar 15 2018, In : American Journal of Cardiology. 121, 6, p. 768-774 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Potentially modifiable factors of dofetilide-associated risk of torsades de pointes among hospitalized patients with atrial fibrillation

Naksuk, N., Sugrue, A. M., Padmanabhan, D., Kella, D., DeSimone, C. V., Kapa, S., Asirvatham, S. J., Lee, H. C., Ackerman, M. J. & Noseworthy, P., Jan 1 2018, (Accepted/In press) In : Journal of Interventional Cardiac Electrophysiology.

Research output: Contribution to journalArticle

1 Scopus citations

Prevalence and clinical phenotype of concomitant long QT syndrome and arrhythmogenic bileaflet mitral valve prolapse

Giudicessi, J. R., Rohatgi, R. K., Bos, J. M. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

1 Scopus citations

QT prolongation and sudden cardiac death risk in hypertrophic cardiomyopathy

Patel, S. I., Ackerman, M. J., Shamoun, F. E., Geske, J. B., Ommen, S. R., Love, W. T., Cha, S. S., Bos, J. M. & Lester, S. J., Mar 6 2018, (Accepted/In press) In : Acta Cardiologica. p. 1-6 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Reappraisal of Reported Genes for Sudden Arrhythmic Death

National Institutes of Health Clinical Genome Resource Consortium, Sep 18 2018, In : Circulation. 138, 12, p. 1195-1205 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Return-to-play for athletes with genetic heart diseases

Turkowski, K. L., Martijn Bos, J., Ackerman, N. C., Rohatgi, R. K. & Ackerman, M. J., Mar 1 2018, In : Circulation. 137, 10, p. 1086-1088 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Role of genetic heart disease in sentinel sudden cardiac arrest survivors across the age spectrum

Giudicessi, J. R. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

5 Scopus citations

Safety of Sports for Young Patients With Implantable Cardioverter-Defibrillators

Saarel, E. V., Law, I., Berul, C. I., Ackerman, M. J., Kanter, R. J., Sanatani, S., Cohen, M. I., Berger, S., Fischbach, P. S., Burton, D. A., Dziura, J., Brandt, C., Simone, L., Li, F., Olshansky, B., Cannom, D. S. & Lampert, R. J., Nov 1 2018, In : Circulation. Arrhythmia and electrophysiology. 11, 11, p. e006305

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

SCN5A mutations in 442 neonates and children: Genotype-phenotype correlation and identification of higher-risk subgroups

Baruteau, A. E., Kyndt, F., Behr, E. R., Vink, A. S., Lachaud, M., Joong, A., Schott, J. J., Horie, M., Denjoy, I., Crotti, L., Shimizu, W., Bos, J. M., Stephenson, E. A., Wong, L., Abrams, D. J., Davis, A. M., Winbo, A., Dubin, A. M., Sanatani, S., Liberman, L. & 31 others, Kaski, J. P., Rudic, B., Kwok, S. Y., Rieubland, C., Tfelt-Hansen, J., Van Hare, G. F., Guyomarc'h-Delasalle, B., Blom, N. A., Wijeyeratne, Y. D., Gourraud, J. B., Marec, H. L., Ozawa, J., Fressart, V., Lupoglazoff, J. M., Dagradi, F., Spazzolini, C., Aiba, T., Tester, D. J., Zahavich, L. A., Beauséjour-Ladouceur, V., Jadhav, M., Skinner, J. R., Franciosi, S., Krahn, A. D., Abdelsayed, M., Ruben, P. C., Yung, T. C., Ackerman, M. J., Wilde, A. A., Schwartz, P. J. & Probst, V., Aug 1 2018, In : European Heart Journal. 39, 31, p. 2879-2887 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Supraventricular tachycardias, conduction disease, and cardiomyopathy in 3 families with the same rare variant in TNNI3K (p.Glu768Lys)

Podliesna, S., Delanne, J., Miller, L., Tester, D. J., Uzunyan, M., Yano, S., Klerk, M., Cannon, B. C., Khongphatthanayothin, A., Laurent, G., Bertaux, G., Falcon-Eicher, S., Wu, S., Yen, H. Y., Gao, H., Wilde, A. A. M., Faivre, L., Ackerman, M. J., Lodder, E. M. & Bezzina, C. R., Jan 1 2018, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

2 Scopus citations

The genetic architecture of long QT syndrome: A critical reappraisal

Giudicessi, J. R., Wilde, A. A. M. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : Trends in Cardiovascular Medicine.

Research output: Contribution to journalArticle

17 Scopus citations

Using the genome aggregation database, computational pathogenicity prediction tools, and patch clamp heterologous expression studies to demote previously published long QT syndrome type 1 mutations from pathogenic to benign

Clemens, D. J., Lentino, A. R., Kapplinger, J. D., Ye, D., Zhou, W., Tester, D. J. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

8 Scopus citations

Wearable cardioverter defibrillators for patients with long QT syndrome

Owen, H. J., Bos, J. M. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

6 Scopus citations

Yield of the RYR2 Genetic Test in Suspected Catecholaminergic Polymorphic Ventricular Tachycardia and Implications for Test Interpretation

Kapplinger, J. D., Pundi, K. N., Larson, N., Callis, T. E., Tester, D. J., Bikker, H., Wilde, A. A. M. & Ackerman, M. J., Feb 1 2018, In : Circulation. Genomic and precision medicine. 11, 2, p. e001424

Research output: Contribution to journalArticle

10 Scopus citations
2017

A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene

Ding, Y., Long, P. A., Bos, J. M., Shih, Y. H., Ma, X., Sundsbak, R. S., Chen, J., Jiang, Y., Zhao, L., Hu, X., Wang, J., Shi, Y., Ackerman, M. J., Lin, X., Ekker, S. C., Redfield, M. M., Olson, T. M. & Xu, X. H., Apr 20 2017, In : JCI insight. 2, 8

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome

Limpitikul, W. B., Dick, I. E., Tester, D. J., Boczek, N. J., Limphong, P., Yang, W., Choi, M. H., Babich, J., Disilvestre, D., Kanter, R. J., Tomaselli, G. F., Ackerman, M. J. & Yue, D. T., Jan 6 2017, In : Circulation Research. 120, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Architectural T-Wave Analysis and Identification of On-Therapy Breakthrough Arrhythmic Risk in Type 1 and Type 2 Long-QT Syndrome

Sugrue, A., Rohatgi, R. K., Noseworthy, P., Kremen, V., Bos, J. M., Qiang, B., Sapir, Y., Attia, Z. I., Scott, C. G., Brady, P., Asirvatham, S. J., Friedman, P. A. & Ackerman, M. J., Nov 1 2017, In : Circulation. Arrhythmia and electrophysiology. 10, 11

Research output: Contribution to journalArticle

1 Scopus citations

Automated T-wave analysis can differentiate acquired QT prolongation from congenital long QT syndrome

Sugrue, A., Noseworthy, P., Kremen, V., Bos, J. M., Qiang, B., Rohatgi, R. K., Sapir, Y., Attia, Z. I., Brady, P., Caraballo, P., Asirvatham, S. J., Friedman, P. A. & Ackerman, M. J., 2017, (Accepted/In press) In : Annals of Noninvasive Electrocardiology.

Research output: Contribution to journalArticle

2 Scopus citations