Michael John Ackerman

1991

Two novel cardiac atrial K⁺ channels, I_K.AA and I_K.PC

Wallert, M. A., Ackerman, M. J., Kim, D. & Clapham, D. E., Nov 1 1991, In : Journal of General Physiology. 98, 5, p. 921-939 19 p.

Research output: Contribution to journal › Article

Open Access

25 Scopus citations

1992

New mammalian chloride channel identified by expression cloning

Paulmichl, M., Li, Y., Wickman, K., Ackerman, M., Peralta, E. & Clapham, D., Jan 1 1992, In : Nature. 356, 6366, p. 238-241 4 p.

Research output: Contribution to journal › Article

298 Scopus citations

1993

Cardiac chloride channels

Ackerman, M. J. & Clapham, D. E., Jan 1 1993, In : Trends in cardiovascular medicine. 3, 1, p. 23-28 6 p.

Research output: Contribution to journal › Short survey

52 Scopus citations

1994

Characterization of a native swelling-induced chloride current, ICl.swell, and its regulatory protein, pICln, in Xenopus oocytes.

Ackerman, M. J., Krapivinsky, G. B., Gordon, E., Krapivinsky, L. & Clapham, D. C., 1994, In : The Japanese journal of physiology. 44 Suppl 2, p. S17-24

Research output: Contribution to journal › Article

14 Scopus citations

Hypotonicity activates a native chloride current in Xenopus oocytes

Ackerman, M. J., Wickman, K. D. & Clapham, D. E., Feb 1 1994, In : Journal of General Physiology. 103, 2, p. 153-179 27 p.

Research output: Contribution to journal › Article

Open Access

202 Scopus citations

Molecular characterization of a swelling-induced chloride conductance regulatory protein, pl_CIn

Krapivinsky, G. B., Ackerman, M. J., Gordon, E. A., Krapivinsky, L. D. & Clapham, D. E., Feb 11 1994, In : Cell. 76, 3, p. 439-448 10 p.

Research output: Contribution to journal › Article

183 Scopus citations

1997

Mechanisms of disease: Ion channels - Basic science and clinical disease

Ackerman, M. J. & Clapham, D. E., Jun 14 1997, In : New England Journal of Medicine. 336, 22, p. 1575-1586 12 p.

Research output: Contribution to journal › Review article

287 Scopus citations

1998

A novel mutation in KVLQT1 is the molecular basis of inherited long QT syndrome in a near-drowning patient's family

Ackerman, M. J., Schroeder, J. J., Berry, R., Schaid, D. J., Porter, C. B. J., Michels, V. V. & Thibodeau, S. N., Aug 1998, In : Pediatric Research. 44, 2, p. 148-153 6 p.

Research output: Contribution to journal › Article

Open Access

41 Scopus citations

Identification of a family with inherited long QT syndrome after a pediatric near-drowning

Ackerman, M. J. & Porter, C. B. J., Feb 1998, In : Pediatrics. 101, 2, p. 306-308 3 p.

Research output: Contribution to journal › Article

26 Scopus citations

Long QT syndrome [1] (multiple letters)

Allan, W. C., Ackerman, M. J. & Porter, C. B. J., Jan 1 1998, In : Pediatrics. 102, 5, p. 1220-1221 2 p.

Research output: Contribution to journal › Letter

3 Scopus citations

The long QT syndrome: Ion channel diseases of the heart

Ackerman, M. J., Jan 1 1998, In : Mayo Clinic proceedings. 73, 3, p. 250-269 20 p.

Research output: Contribution to journal › Review article

Open Access

251 Scopus citations

The long QT syndrome.

Ackerman, M. J., Jul 1998, In : Pediatrics in review / American Academy of Pediatrics. 19, 7, p. 232-238 7 p.

Research output: Contribution to journal › Review article

38 Scopus citations

1999

Molecular diagnosis of the inherited long-QT syndrome in a woman who died after near-drowning

Ackerman, M. J., Tester, D. J., Porter, C. B. J. & Edwards, W. D., Oct 7 1999, In : New England Journal of Medicine. 341, 15, p. 1121-1125 5 p.

Research output: Contribution to journal › Article

110 Scopus citations

Swimming, a gene-specific arrhythmogenic trigger for inherited long QT syndrome

Ackerman, M. J., Tester, D. J. & Porter, B. J., Jan 1 1999, In : Mayo Clinic proceedings. 74, 11, p. 1088-1094 7 p.

Research output: Contribution to journal › Article

197 Scopus citations

2000

Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy

Olson, T. M., Doan, T. P., Kishimoto, N. Y., Whitby, F. G., Ackerman, M. J. & Fananapazir, L., Jan 1 2000, In : Journal of Molecular and Cellular Cardiology. 32, 9, p. 1687-1694 8 p.

Research output: Contribution to journal › Article

166 Scopus citations

The long-QT syndrome [2] (multiple letters)

Allan, W. C., Ackerman, M. J. & Porter, C. B. J., Feb 17 2000, In : New England Journal of Medicine. 342, 7, p. 514-515 2 p.

Research output: Contribution to journal › Letter

1 Scopus citations

2001

Cardiac sodium channel gene mutations and sudden infant death syndrome: Confirmation of proof of concept?

Towbin, J. A. & Ackerman, M. J., Sep 4 2001, In : Circulation. 104, 10, p. 1092-1093 2 p.

Research output: Contribution to journal › Editorial

12 Scopus citations

Diagnostic accuracy of screening electrocardiograms in long QT syndrome I

Miller, M. D., Porter, C. B. J. & Ackerman, M. J., Jul 11 2001, In : Pediatrics. 108, 1, p. 8-12 5 p.

Research output: Contribution to journal › Article

38 Scopus citations

Molecular autopsy of sudden unexplained death in the young

Ackerman, M. J., Tester, D. J. & Driscoll, D. J., Jun 11 2001, In : American Journal of Forensic Medicine and Pathology. 22, 2, p. 105-111 7 p.

Research output: Contribution to journal › Article

109 Scopus citations

Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome

Ackerman, M. J., Siu, B. L., Sturner, W. Q., Tester, D. J., Valdivia, C. R., Makielski, J. C. & Towbin, J. A., Nov 14 2001, In : Journal of the American Medical Association. 286, 18, p. 2264-2269 6 p.

Research output: Contribution to journal › Article

Open Access

381 Scopus citations

Pulmonary atresia with ventricular septal defect and persistent airway hyperresponsiveness

Ackerman, M. J., Wylam, M. E., Feldt, R. H., Porter, C. B. J., Dewald, G., Scanlon, P. D. & Driscoll, D. J., Jul 1 2001, In : Journal of Thoracic and Cardiovascular Surgery. 122, 1, p. 169-177 9 p.

Research output: Contribution to journal › Article

19 Scopus citations

2002

A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine

Valdivia, C. R., Ackerman, M. J., Tester, D. J., Wada, T., McCormack, J., Ye, B. & Makielski, J. C., Jul 25 2002, In : Cardiovascular research. 55, 2, p. 279-289 11 p.

Research output: Contribution to journal › Article

75 Scopus citations

A novel TPM1 mutation in a family with hypertrophic cardiomyopathy and sudden cardiac death in childhood

Van Driest, S. L., Will, M. L., Atkins, D. L. & Ackerman, M. J., Nov 15 2002, In : American Journal of Cardiology. 90, 10, p. 1123-1127 5 p.

Research output: Contribution to journal › Article

28 Scopus citations

Cardiac phenotype in the chromosome 22q11.2 microdeletion syndrome

Earing, M., Ackerman, M. J. & Driscoll, D. J., Jan 1 2002, In : Progress in Pediatric cardiology. 15, 2, p. 119-123 5 p.

Research output: Contribution to journal › Article

6 Scopus citations

Diagnostic accuracy of screening electrocardiograms in the long QT syndrome [1] (multiple letters)

Jerome Krovetz, L., Ackerman, M. J. & Porter, C. B. J., May 20 2002, In : Pediatrics. 109, 5, 1 p.

Research output: Contribution to journal › Letter

Epinephrine-induced QT interval prolongation: A gene-specific paradoxical response in congenital long QT syndrome

Ackerman, M. J., Khositseth, A., Tester, D. J., Hejlik, J. B., Shen, W. K. & Porter, C. B. J., Jan 1 2002, In : Mayo Clinic proceedings. 77, 5, p. 413-421 9 p., 62209.

Research output: Contribution to journal › Article

164 Scopus citations

Interaction with GM130 during HERG ion channel trafficking: Disruption by type 2 congenital long QT syndrome mutations

Roti Roti, E. C., Myers, C. D., Ayers, R. A., Boatman, D. E., Delfosse, S. A., Chan, E. K. L., Ackerman, M. J., January, C. T. & Robertson, G. A., Dec 6 2002, In : Journal of Biological Chemistry. 277, 49, p. 47779-47785 7 p.

Research output: Contribution to journal › Article

61 Scopus citations

Prevalence and age-dependence of malignant mutations in the beta-myosin heavy chain and troponin T genes in hypertrophic cardiomyopathy: A comprehensive outpatient perspective

Ackerman, M. J., VanDriest, S. L., Ommen, S. R., Will, M. L., Nishimura, R. A., Tajik, A. J. & Gersh, B. J., Jun 19 2002, In : Journal of the American College of Cardiology. 39, 12, p. 2042-2048 7 p.

Research output: Contribution to journal › Article

198 Scopus citations

Prevalence and severity of "benign" mutations in the β-myosin heavy chain, cardiac troponin T, and α-tropomyosin genes in hypertrophic cardiomyopathy

Van Driest, S. L., Ackerman, M. J., Ommen, S. R., Shakur, R., Will, M. L., Nishimura, R. A., Tajik, A. J. & Gersh, B. J., Dec 10 2002, In : Circulation. 106, 24, p. 3085-3090 6 p.

Research output: Contribution to journal › Article

151 Scopus citations

Role of transvenous implantable cardioverter-defibrillators in preventing sudden cardiac death in children, adolescents, and young adults

Chatrath, R., Porter, C. B. J. & Ackerman, M. J., Jan 1 2002, In : Mayo Clinic proceedings. 77, 3, p. 226-231 6 p., 62353.

Research output: Contribution to journal › Article

66 Scopus citations

SCN5A is expressed in human jejunal circular smooth muscle cells

Ou, Y., Gibbons, S. J., Miller, S. M., Strege, P. R., Rich, A., Distad, M. A., Ackerman, M. J., Rae, J. L., Szurszewski, J. H. & Farrugia, G., Nov 6 2002, In : Neurogastroenterology and Motility. 14, 5, p. 477-486 10 p.

Research output: Contribution to journal › Article

60 Scopus citations

Sex-selective QT prolongation during rapid eye movement sleep

Lanfranchi, P. A., Shamsuzzaman, A. S. M., Ackerman, M. J., Kara, T., Jurak, P., Wolk, R. & Somers, V. K., Sep 17 2002, In : Circulation. 106, 12, p. 1488-1492 5 p.

Research output: Contribution to journal › Article

36 Scopus citations

2003

A common human SCN5A polymorphism modifies expression of an arrhythmia causing mutation

Ye, B., Valdivia, C. R., Ackerman, M. J. & Makielski, J. C., Apr 2003, In : Physiological Genomics. 12, p. 187-193 7 p.

Research output: Contribution to journal › Article

142 Scopus citations

A Ubiquitous Splice Variant and a Common Polymorphism Affect Heterologous Expression of Recombinant Human SCN5A Heart Sodium Channels

Makielski, J. C., Ye, B., Valdivia, C. R., Pagel, M. D., Pu, J., Tester, D. J. & Ackerman, M. J., Oct 31 2003, In : Circulation research. 93, 9, p. 821-828 8 p.

Research output: Contribution to journal › Article

183 Scopus citations

Catecholamine-induced T-wave lability in congenital long QT syndrome: A novel phenomenon associated with syncope and cardiac arrest

Nemec, J., Hejlik, J. B., Shen, W. K. & Ackerman, M. J., Jan 1 2003, In : Mayo Clinic proceedings. 78, 1, p. 40-50 11 p.

Research output: Contribution to journal › Article

47 Scopus citations

Catecholamine-provoked microvoltage T wave alternans in genotyped long QT syndrome

Nemec, J., Ackerman, M. J., Tester, D. J., Hejlik, J. & Shen, W. K., Aug 1 2003, In : PACE - Pacing and Clinical Electrophysiology. 26, 8, p. 1660-1667 8 p.

Research output: Contribution to journal › Article

22 Scopus citations

Diastolic Ventricular Dysfunction as a Marker for Hypertrophic Cardiomyopathy in a Family with a Novel Alpha-Tropomyosin Mutation

Earing, M. G., Ackerman, M. J. & O'Leary, P. W., Jun 2003, In : Journal of the American Society of Echocardiography. 16, 6, p. 698-702 5 p.

Research output: Contribution to journal › Article

6 Scopus citations

Effect of phenylephrine provocation on dispersion of repolarization in congenital long QT syndrome

Khositseth, A., Nemec, J., Hejlik, J., Shen, W. K. & Ackerman, M. J., Jul 1 2003, In : Annals of Noninvasive Electrocardiology. 8, 3, p. 208-214 7 p.

Research output: Contribution to journal › Article

11 Scopus citations

Ethnic Differences in Cardiac Potassium Channel Variants: Implications for Genetic Susceptibility to Sudden Cardiac Death and Genetic Testing for Congenital Long QT Syndrome

Ackerman, M. J., Tester, D. J., Jones, G. S., Will, M. L., Burrow, C. R. & Curran, M. E., Dec 2003, In : Mayo Clinic proceedings. 78, 12, p. 1479-1487 9 p.

Research output: Contribution to journal › Article

249 Scopus citations

Management of ventricular fibrillation or unstable ventricular tachycardia in patients with congenital long-QT syndrome: A suggested modification to ACLS guidelines

Homme, J. H., White, R. D. & Ackerman, M. J., Oct 2003, In : Resuscitation. 59, 1, p. 111-115 5 p.

Research output: Contribution to journal › Article

6 Scopus citations

Prevalence and spectrum of thin filament mutations in an outpatient referral population with hypertrophic cardiomyopathy

Van Driest, S. L., Ellsworth, E. G., Ommen, S. R., Tajik, A. J., Gersh, B. J. & Ackerman, M. J., Jul 29 2003, In : Circulation. 108, 4, p. 445-451 7 p.

Research output: Contribution to journal › Article

170 Scopus citations

Primer on medical genomics part VI: Genomics and molecular genetics in clinical practice

Ansell, S. M., Ackerman, M. J., Black, J. L., Roberts, L. R. & Tefferi, A., Mar 1 2003, In : Mayo Clinic proceedings. 78, 3, p. 307-317 11 p.

Research output: Contribution to journal › Article

16 Scopus citations

Primer on medical genomics part VIII: Essentials of medical genetics for the practicing physician

Ensenauer, R. E., Reinke, S. S., Ackerman, M. J., Tester, D. J., Whiteman, D. A. H. & Tefferi, A., Jul 1 2003, In : Mayo Clinic proceedings. 78, 7, p. 846-857 12 p.

Research output: Contribution to journal › Review article

14 Scopus citations

Sudden unexplained death: Evaluation of those left behind

Lee, A. & Ackerman, M. J., Nov 1 2003, In : Lancet. 362, 9394, p. 1429-1431 3 p.

Research output: Contribution to journal › Comment/debate

11 Scopus citations

Sympathetic nerve activity in the congenital long-QT syndrome

Shamsuzzaman, A. S. M., Ackerman, M. J., Kara, T., Lanfranchi, P. & Somers, V. K., Apr 15 2003, In : Circulation. 107, 14, p. 1844-1847 4 p.

Research output: Contribution to journal › Article

16 Scopus citations

Syncope in children and adolescents and the congenital long QT syndrome

Khositseth, A., Martinez, M. W., Driscoll, D. J. & Ackerman, M. J., Sep 15 2003, In : American Journal of Cardiology. 92, 6, p. 746-749 4 p.

Research output: Contribution to journal › Article

10 Scopus citations

Syntrophin γ2 regulates SCN5A gating by a PDZ domain-mediated interaction

Ou, Y., Strege, P., Miller, S. M., Makielski, J., Ackerman, M., Gibbons, S. J. & Farrugia, G., Jan 17 2003, In : Journal of Biological Chemistry. 278, 3, p. 1915-1923 9 p.

Research output: Contribution to journal › Article

91 Scopus citations

The immeasurable value of the "breath of life".

Ackerman, M. J., Jan 1 2003, In : La Pediatria medica e chirurgica : Medical and surgical pediatrics. 25, 6, 1 p.

Research output: Contribution to journal › Article

2004

A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs

Valdivia, C. R., Tester, D. J., Rok, B. A., Porter, C. B. J., Munger, T. M., Jahangir, A., Makielski, J. C. & Ackerman, M. J., Apr 1 2004, In : Cardiovascular research. 62, 1, p. 53-62 10 p.

Research output: Contribution to journal › Article

103 Scopus citations

Cardiac channelopathies: It's in the genes

Ackerman, M. J., May 1 2004, In : Nature Medicine. 10, 5, p. 463-464 2 p.

Research output: Contribution to journal › Short survey

130 Scopus citations

Michael John Ackerman, MD, PhD, FACC