Michael John Ackerman, MD, PhD, FACC

  • 34801 Citations
  • 103 Scopus h-Index
1991 …2020
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Research Output 1991 2019

1991
25 Citations (Scopus)

Two novel cardiac atrial K+ channels, IK.AA and IK.PC

Wallert, M. A., Ackerman, M. J., Kim, D. & Clapham, D. E., Nov 1991, In : Journal of General Physiology. 98, 5, p. 921-939 19 p.

Research output: Contribution to journalArticle

Arachidonic Acid
Fatty Acids
Choline
Phosphatidylcholines
Detergents
1992
296 Citations (Scopus)

New mammalian chloride channel identified by expression cloning

Paulmichl, M., Li, Y., Wickman, K., Ackerman, M. J., Peralta, E. & Clapham, D., Mar 19 1992, In : Nature. 356, 6366, p. 238-241 4 p.

Research output: Contribution to journalArticle

Chloride Channels
Organism Cloning
Chlorides
Nucleotides
Complementary DNA
1993
52 Citations (Scopus)

Cardiac chloride channels

Ackerman, M. J. & Clapham, D. E., 1993, In : Trends in Cardiovascular Medicine. 3, 1, p. 23-28 6 p.

Research output: Contribution to journalArticle

Chloride Channels
Protein Transport
Ion Channels
Action Potentials
1994
14 Citations (Scopus)

Characterization of a native swelling-induced chloride current, ICl.swell, and its regulatory protein, pICln, in Xenopus oocytes.

Ackerman, M. J., Krapivinsky, G. B., Gordon, E., Krapivinsky, L. & Clapham, D. C., 1994, In : Japanese Journal of Physiology. 44 Suppl 2

Research output: Contribution to journalArticle

Xenopus
Oocytes
Chlorides
Proteins
Chloride Channels
200 Citations (Scopus)

Hypotonicity activates a native chloride current in Xenopus oocytes

Ackerman, M. J., Wickman, K. D. & Clapham, D. E., Feb 1994, In : Journal of General Physiology. 103, 2, p. 153-179 27 p.

Research output: Contribution to journalArticle

Xenopus
Oocytes
Chlorides
Chloride Channels
Lanthanoid Series Elements
182 Citations (Scopus)

Molecular characterization of a swelling-induced chloride conductance regulatory protein, plCln

Krapivinsky, G. B., Ackerman, M. J., Gordon, E. A., Krapivinsky, L. D. & Clapham, D. E., 1994, In : Cell. 76, 3, p. 439-448 10 p.

Research output: Contribution to journalArticle

Xenopus
Swelling
Chlorides
Oocytes
Proteins
1997
281 Citations (Scopus)

Mechanisms of disease: Ion channels - Basic science and clinical disease

Ackerman, M. J. & Clapham, D. E., 1997, In : New England Journal of Medicine. 336, 22, p. 1575-1586 12 p.

Research output: Contribution to journalArticle

Purinergic P2 Receptors
Long QT Syndrome
Potassium Channels
Cell Surface Receptors
Molecular Cloning
1998
41 Citations (Scopus)

A novel mutation in KVLQT1 is the molecular basis of inherited long QT syndrome in a near-drowning patient's family

Ackerman, M. J., Schroeder, J. J., Berry, R., Schaid, D. J., Porter, C. B. J., Michels, V. V. & Thibodeau, S. N., Aug 1998, In : Pediatric Research. 44, 2, p. 148-153 6 p.

Research output: Contribution to journalArticle

Near Drowning
Long QT Syndrome
Mutation
Electrocardiography
Genotype
26 Citations (Scopus)

Identification of a family with inherited long QT syndrome after a pediatric near-drowning

Ackerman, M. J. & Porter, C. B. J., 1998, In : Pediatrics. 101, 2, p. 306-308 3 p.

Research output: Contribution to journalArticle

Near Drowning
Long QT Syndrome
Pediatrics
3 Citations (Scopus)

Long QT syndrome [1] (multiple letters)

Allan, W. C., Ackerman, M. J. & Porter, C. B. J., 1998, In : Pediatrics. 102, 5, p. 1220-1221 2 p.

Research output: Contribution to journalArticle

Romano-Ward Syndrome
248 Citations (Scopus)

The long QT syndrome: Ion channel diseases of the heart

Ackerman, M. J., 1998, In : Mayo Clinic Proceedings. 73, 3, p. 250-269 20 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Ion Channels
Heart Diseases
Genes
Action Potentials
38 Citations (Scopus)

The long QT syndrome.

Ackerman, M. J., Jul 1998, In : Pediatrics in review / American Academy of Pediatrics. 19, 7, p. 232-238 7 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Jervell-Lange Nielsen Syndrome
Incidence
Romano-Ward Syndrome
Consanguinity
1999
108 Citations (Scopus)

Molecular diagnosis of the inherited long-QT syndrome in a woman who died after near-drowning

Ackerman, M. J., Tester, D. J., Porter, C. B. J. & Edwards, W. D., Oct 7 1999, In : New England Journal of Medicine. 341, 15, p. 1121-1125 5 p.

Research output: Contribution to journalArticle

KCNQ Potassium Channels
KCNQ1 Potassium Channel
Near Drowning
Voltage-Gated Potassium Channels
Long QT Syndrome
193 Citations (Scopus)

Swimming, a gene-specific arrhythmogenic trigger for inherited long QT syndrome

Ackerman, M. J., Tester, D. J. & Porter, B. J., 1999, In : Mayo Clinic Proceedings. 74, 11, p. 1088-1094 7 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Near Drowning
Mutation
Genes
RNA Splice Sites
2000
161 Citations (Scopus)

Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy

Olson, T. M., Doan, T. P., Kishimoto, N. Y., Whitby, F. G., Ackerman, M. J. & Fananapazir, L., 2000, In : Journal of Molecular and Cellular Cardiology. 32, 9, p. 1687-1694 8 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Actins
Mutation
Genes
Missense Mutation
1 Citation (Scopus)

The long-QT syndrome [2] (multiple letters)

Allan, W. C., Ackerman, M. J. & Porter, C. B. J., Feb 17 2000, In : New England Journal of Medicine. 342, 7, p. 514-515 2 p.

Research output: Contribution to journalArticle

Near Drowning
False Positive Reactions
Long QT Syndrome
Adrenergic beta-Antagonists
Genetic Testing
2001
12 Citations (Scopus)

Cardiac sodium channel gene mutations and sudden infant death syndrome: Confirmation of proof of concept?

Towbin, J. A. & Ackerman, M. J., Sep 4 2001, In : Circulation. 104, 10, p. 1092-1093 2 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Sudden Infant Death
Sodium Channels
Sudden Death
Ion Channels
37 Citations (Scopus)

Diagnostic accuracy of screening electrocardiograms in long QT syndrome I

Miller, M. D., Porter, C. B. J. & Ackerman, M. J., 2001, In : Pediatrics. 108, 1, p. 8-12 5 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Electrocardiography
Syncope
Sudden Death
Ion Channels
105 Citations (Scopus)

Molecular autopsy of sudden unexplained death in the young

Ackerman, M. J., Tester, D. J. & Driscoll, D. J., 2001, In : American Journal of Forensic Medicine and Pathology. 22, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Sudden Death
Autopsy
death
Genes
374 Citations (Scopus)

Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome

Ackerman, M. J., Siu, B. L., Sturner, W. Q., Tester, D. J., Valdivia, C. R., Makielski, J. C. & Towbin, J. A., Nov 14 2001, In : Journal of the American Medical Association. 286, 18, p. 2264-2269 6 p.

Research output: Contribution to journalArticle

Sudden Infant Death
Mutation
Sodium Channels
Long QT Syndrome
Missense Mutation
19 Citations (Scopus)

Pulmonary atresia with ventricular septal defect and persistent airway hyperresponsiveness

Ackerman, M. J., Wylam, M., Feldt, R. H., Porter, C. B. J., Dewald, G., Scanlon, P. D. & Driscoll, D. J., Jul 1 2001, In : Journal of Thoracic and Cardiovascular Surgery. 122, 1, p. 169-177 9 p.

Research output: Contribution to journalArticle

Pulmonary Atresia
Haploinsufficiency
Chromosomes
Ventricular Heart Septal Defects
Asthma
2002
74 Citations (Scopus)

A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine

Valdivia, C. R., Ackerman, M. J., Tester, D. J., Wada, T., McCormack, J., Ye, B. & Makielski, J. C., 2002, In : Cardiovascular Research. 55, 2, p. 279-289 11 p.

Research output: Contribution to journalArticle

Mexiletine
Cardiac Arrhythmias
Sodium Channels
Mutation
Sodium
28 Citations (Scopus)

A novel TPM1 mutation in a family with hypertrophic cardiomyopathy and sudden cardiac death in childhood

Van Driest, S. L., Will, M. L., Atkins, D. L. & Ackerman, M. J., Nov 15 2002, In : American Journal of Cardiology. 90, 10, p. 1123-1127 5 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Sudden Cardiac Death
Mutation
Tropomyosin
Missense Mutation
6 Citations (Scopus)

Cardiac phenotype in the chromosome 22q11.2 microdeletion syndrome

Earing, M., Ackerman, M. J. & Driscoll, D. J., 2002, In : Progress in Pediatric Cardiology. 15, 2, p. 119-123 5 p.

Research output: Contribution to journalArticle

DiGeorge Syndrome
Chromosomes
Chromosome Deletion
Phenotype
Heart Diseases

Diagnostic accuracy of screening electrocardiograms in the long QT syndrome [1] (multiple letters)

Jerome Krovetz, L., Ackerman, M. J. & Porter, C. B. J., 2002, In : Pediatrics. 109, 5, p. 985 1 p.

Research output: Contribution to journalArticle

Romano-Ward Syndrome
Computer-Assisted Diagnosis
Predictive Value of Tests
Long QT Syndrome
Electrocardiography
162 Citations (Scopus)

Epinephrine-induced QT interval prolongation: A gene-specific paradoxical response in congenital long QT syndrome

Ackerman, M. J., Khositseth, A., Tester, D. J., Hejlik, J. B., Shen, W. K. & Porter, C. B. J., 2002, In : Mayo Clinic Proceedings. 77, 5, p. 413-421 9 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Epinephrine
Genes
Romano-Ward Syndrome
Heart Rate
60 Citations (Scopus)

Interaction with GM130 during HERG ion channel trafficking: Disruption by type 2 congenital long QT syndrome mutations

Roti Roti, E. C., Myers, C. D., Ayers, R. A., Boatman, D. E., Delfosse, S. A., Chan, E. K. L., Ackerman, M. J., January, C. T. & Robertson, G. A., Dec 6 2002, In : Journal of Biological Chemistry. 277, 49, p. 47779-47785 7 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Ion Channels
Ether
Genes
Mutation
195 Citations (Scopus)

Prevalence and age-dependence of malignant mutations in the beta-myosin heavy chain and troponin T genes in hypertrophic cardiomyopathy: A comprehensive outpatient perspective

Ackerman, M. J., VanDriest, S. L., Ommen, S. R., Will, M. L., Nishimura, R. A., Tajik, A. J. & Gersh, B. J., Jun 19 2002, In : Journal of the American College of Cardiology. 39, 12, p. 2042-2048 7 p.

Research output: Contribution to journalArticle

Ventricular Myosins
Troponin T
Myosin Heavy Chains
Hypertrophic Cardiomyopathy
Outpatients
149 Citations (Scopus)

Prevalence and severity of "benign" mutations in the β-myosin heavy chain, cardiac troponin T, and α-tropomyosin genes in hypertrophic cardiomyopathy

Van Driest, S. L., Ackerman, M. J., Ommen, S. R., Shakur, R., Will, M. L., Nishimura, R. A., Tajik, A. J. & Gersh, B. J., Dec 10 2002, In : Circulation. 106, 24, p. 3085-3090 6 p.

Research output: Contribution to journalArticle

Tropomyosin
Troponin T
Myosin Heavy Chains
Hypertrophic Cardiomyopathy
Mutation
66 Citations (Scopus)

Role of transvenous implantable cardioverter-defibrillators in preventing sudden cardiac death in children, adolescents, and young adults

Chatrath, R., Porter, C. B. J. & Ackerman, M. J., 2002, In : Mayo Clinic Proceedings. 77, 3, p. 226-231 6 p.

Research output: Contribution to journalArticle

Implantable Defibrillators
Sudden Cardiac Death
Young Adult
Secondary Prevention
Long QT Syndrome
57 Citations (Scopus)

SCN5A is expressed in human jejunal circular smooth muscle cells

Ou, Y., Gibbons, S. J., Miller, S. M., Strege, P. R., Rich, A., Distad, M. A., Ackerman, M. J., Rae, J. L., Szurszewski, J. H. & Farrugia, G., 2002, In : Neurogastroenterology and Motility. 14, 5, p. 477-486 10 p.

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Tetrodotoxin
Reverse Transcriptase Polymerase Chain Reaction
Complementary DNA
Laser Capture Microdissection
35 Citations (Scopus)

Sex-selective QT prolongation during rapid eye movement sleep

Lanfranchi, P. A., Shamsuzzaman, A. S. M., Ackerman, M. J., Kara, T., Jurak, P., Wolk, R. & Somers, V., Sep 17 2002, In : Circulation. 106, 12, p. 1488-1492 5 p.

Research output: Contribution to journalArticle

Wakefulness
Sleep Stages
REM Sleep
Sleep
Healthy Volunteers
2003
140 Citations (Scopus)

A common human SCN5A polymorphism modifies expression of an arrhythmia causing mutation

Ye, B., Valdivia, C. R., Ackerman, M. J. & Makielski, J. C., Apr 2003, In : Physiological Genomics. 12, p. 187-193 7 p.

Research output: Contribution to journalArticle

Cardiac Arrhythmias
Clone Cells
Mutation
Gene Library
Ion Channels
181 Citations (Scopus)

A Ubiquitous Splice Variant and a Common Polymorphism Affect Heterologous Expression of Recombinant Human SCN5A Heart Sodium Channels

Makielski, J. C., Ye, B., Valdivia, C. R., Pagel, M. D., Pu, J., Tester, D. J. & Ackerman, M. J., Oct 31 2003, In : Circulation Research. 93, 9, p. 821-828 8 p.

Research output: Contribution to journalArticle

Sodium Channels
Clone Cells
Myocardium
HEK293 Cells
Nucleic Acid Databases
46 Citations (Scopus)

Catecholamine-induced T-wave lability in congenital long QT syndrome: A novel phenomenon associated with syncope and cardiac arrest

Nemec, J., Hejlik, J. B., Shen, W. K. & Ackerman, M. J., Jan 1 2003, In : Mayo Clinic Proceedings. 78, 1, p. 40-50 11 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Syncope
Heart Arrest
Catecholamines
Dobutamine
22 Citations (Scopus)

Catecholamine-provoked microvoltage T wave alternans in genotyped long QT syndrome

Nemec, J., Ackerman, M. J., Tester, D. J., Hejlik, J. & Shen, W. K., Aug 1 2003, In : PACE - Pacing and Clinical Electrophysiology. 26, 8, p. 1660-1667 8 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Catecholamines
Heart Rate
Dobutamine
Out-of-Hospital Cardiac Arrest
6 Citations (Scopus)
Ventricular Dysfunction
Tropomyosin
Hypertrophic Cardiomyopathy
Familial Hypertrophic Cardiomyopathy
Mutation
11 Citations (Scopus)

Effect of phenylephrine provocation on dispersion of repolarization in congenital long QT syndrome

Khositseth, A., Nemec, J., Hejlik, J., Shen, W. K. & Ackerman, M. J., Jul 2003, In : Annals of Noninvasive Electrocardiology. 8, 3, p. 208-214 7 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Phenylephrine
Syncope
Bradycardia
Sudden Death
244 Citations (Scopus)

Ethnic Differences in Cardiac Potassium Channel Variants: Implications for Genetic Susceptibility to Sudden Cardiac Death and Genetic Testing for Congenital Long QT Syndrome

Ackerman, M. J., Tester, D. J., Jones, G. S., Will, M. L., Burrow, C. R. & Curran, M. E., 2003, In : Mayo Clinic Proceedings. 78, 12, p. 1479-1487 9 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Potassium Channels
Sudden Cardiac Death
Genetic Testing
Genetic Predisposition to Disease
6 Citations (Scopus)
Advanced Cardiac Life Support
Long QT Syndrome
Ventricular Fibrillation
Ventricular Tachycardia
Guidelines
164 Citations (Scopus)

Prevalence and spectrum of thin filament mutations in an outpatient referral population with hypertrophic cardiomyopathy

Van Driest, S. L., Ellsworth, E. G., Ommen, S. R., Tajik, A. J., Gersh, B. J. & Ackerman, M. J., Jul 29 2003, In : Circulation. 108, 4, p. 445-451 7 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Outpatients
Referral and Consultation
Mutation
Population
16 Citations (Scopus)

Primer on medical genomics part VI: Genomics and molecular genetics in clinical practice

Ansell, S. M., Ackerman, M. J., Black, J. L., Roberts, L. R. & Tefferi, A., Mar 1 2003, In : Mayo Clinic Proceedings. 78, 3, p. 307-317 11 p.

Research output: Contribution to journalArticle

Genomics
Molecular Biology
Genes
Forensic Anthropology
Modern 1601-history
14 Citations (Scopus)

Primer on medical genomics part VIII: Essentials of medical genetics for the practicing physician

Ensenauer, R. E., Reinke, S. S., Ackerman, M. J., Tester, D. J., Whiteman, D. A. H. & Tefferi, A., Jul 1 2003, In : Mayo Clinic Proceedings. 78, 7, p. 846-857 12 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Medical Genetics
Genomics
Physicians
Medicine
11 Citations (Scopus)

Sudden unexplained death: Evaluation of those left behind

Lee, A. & Ackerman, M. J., Nov 1 2003, In : Lancet. 362, 9394, p. 1429-1431 3 p.

Research output: Contribution to journalArticle

Sudden Death
16 Citations (Scopus)

Sympathetic nerve activity in the congenital long-QT syndrome

Shamsuzzaman, A. S. M., Ackerman, M. J., Kara, T., Lanfranchi, P. & Somers, V., Apr 15 2003, In : Circulation. 107, 14, p. 1844-1847 4 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Muscles
Skin
Blood Vessels
Heart Rate
10 Citations (Scopus)

Syncope in children and adolescents and the congenital long QT syndrome

Khositseth, A., Martinez, M. W., Driscoll, D. J. & Ackerman, M. J., Sep 15 2003, In : American Journal of Cardiology. 92, 6, p. 746-749 4 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Syncope
Electrocardiography
Heart Rate
Population
88 Citations (Scopus)

Syntrophin γ2 regulates SCN5A gating by a PDZ domain-mediated interaction

Ou, Y., Strege, P., Miller, S. M., Makielski, J., Ackerman, M. J., Gibbons, S. J. & Farrugia, G., Jan 17 2003, In : Journal of Biological Chemistry. 278, 3, p. 1915-1923 9 p.

Research output: Contribution to journalArticle

PDZ Domains
Muscle
Microdissection
Availability
Laser Capture Microdissection

The immeasurable value of the "breath of life".

Ackerman, M. J., Nov 2003, In : La Pediatria medica e chirurgica : Medical and surgical pediatrics. 25, 6, p. 468 1 p.

Research output: Contribution to journalArticle

Altruism
Value of Life
Religion
Cooperative Behavior
2004
100 Citations (Scopus)

A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs

Valdivia, C. R., Tester, D. J., Rok, B. A., Porter, C. B. J., Munger, T. M., Jahangir, A., Makielski, J. C. & Ackerman, M. J., Apr 1 2004, In : Cardiovascular Research. 62, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

Brugada Syndrome
Mutation
Mexiletine
Pharmaceutical Preparations
Sodium Channels
125 Citations (Scopus)

Cardiac channelopathies: It's in the genes

Ackerman, M. J., May 2004, In : Nature Medicine. 10, 5, p. 463-464 2 p.

Research output: Contribution to journalArticle

Channelopathies
Cardiology
Long QT Syndrome
Dissection
Molecular Models