Michael John Ackerman, MD, PhD, FACC

  • 35999 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2020

An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome

Adler, A., Novelli, V., Amin, A. S., Abiusi, E., Care, M., Nannenberg, E. A., Feilotter, H., Amenta, S., Mazza, D., Bikker, H., Sturm, A. C., Garcia, J., Ackerman, M. J., Hershberger, R. E., Perez, M. V., Zareba, W., Ware, J. S., Wilde, A. A. M. & Gollob, M. H., Feb 11 2020, In : Circulation. 141, 6, p. 418-428 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cardiac Magnetic Resonance Imaging Features in Hypertrophic Cardiomyopathy Diagnosed at <21 Years of Age

Bonura, E. D., Bos, J. M., Abdelsalam, M. A., Araoz, P. A., Ommen, S. R., Ackerman, M. J. & Geske, J. B., Jan 1 2020, (Accepted/In press) In : American Journal of Cardiology. 125, 8, p. 1249-1255 7 p.

Research output: Contribution to journalArticle

Detection of Hypertrophic Cardiomyopathy Using a Convolutional Neural Network-Enabled Electrocardiogram

Ko, W. Y., Siontis, K. C., Attia, Z. I., Carter, R. E., Kapa, S., Ommen, S. R., Demuth, S. J., Ackerman, M. J., Gersh, B. J., Arruda-Olson, A. M., Geske, J. B., Asirvatham, S. J., Lopez-Jimenez, F., Nishimura, R. A., Friedman, P. A. & Noseworthy, P. A., Feb 25 2020, In : Journal of the American College of Cardiology. 75, 7, p. 722-733 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Systematic Review of the Genetics of Sudden Unexpected Death in Epilepsy: Potential Overlap With Sudden Cardiac Death and Arrhythmia-Related Genes

Chahal, C. A. A., Salloum, M. N., Alahdab, F., Gottwald, J. A., Tester, D. J., Anwer, L. A., So, E. L., Murad, M. H., St Louis, E. K., Ackerman, M. J. & Somers, V. K., Jan 7 2020, In : Journal of the American Heart Association. 9, 1, p. e012264

Research output: Contribution to journalArticle

Open Access

Variant Frequency and Clinical Phenotype Call Into Question the Nature of Minor, Nonsyndromic Long-QT Syndrome-Susceptibility Gene-Disease Associations

Giudicessi, J. R., Rohatgi, R. K., Tester, D. J. & Ackerman, M. J., Feb 11 2020, In : Circulation. 141, 6, p. 495-497 3 p.

Research output: Contribution to journalLetter

2019

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary

Towbin, J. A., McKenna, W. J., Abrams, D. J., Ackerman, M. J., Calkins, H., Darrieux, F. C. C., Daubert, J. P., de Chillou, C., DePasquale, E. C., Desai, M. Y., Estes, N. A. M., Hua, W., Indik, J. H., Ingles, J., James, C. A., John, R. M., Judge, D. P., Keegan, R., Krahn, A. D., Link, M. S. & 10 others, Marcus, F. I., McLeod, C. J., Mestroni, L., Priori, S. G., Saffitz, J. E., Sanatani, S., Shimizu, W., van Tintelen, J. P., Wilde, A. A. M. & Zareba, W., Nov 2019, In : Heart rhythm. 16, 11, p. e373-e407

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy

Towbin, J. A., McKenna, W. J., Abrams, D. J., Ackerman, M. J., Calkins, H., Darrieux, F. C. C., Daubert, J. P., de Chillou, C., DePasquale, E. C., Desai, M. Y., Estes, N. A. M., Hua, W., Indik, J. H., Ingles, J., James, C. A., John, R. M., Judge, D. P., Keegan, R., Krahn, A. D., Link, M. S. & 10 others, Marcus, F. I., McLeod, C. J., Mestroni, L., Priori, S. G., Saffitz, J. E., Sanatani, S., Shimizu, W., van Tintelen, J. P., Wilde, A. A. M. & Zareba, W., Nov 2019, In : Heart rhythm. 16, 11, p. e301-e372

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
1 Scopus citations
3 Scopus citations

Assessment and Validation of a Phenotype-Enhanced Variant Classification Framework to Promote or Demote RYR2 Missense Variants of Uncertain Significance

Giudicessi, J. R., Lieve, K. V. V., Rohatgi, R. K., Koca, F., Tester, D. J., van der Werf, C., Martijn Bos, J., Wilde, A. A. M. & Ackerman, M. J., May 1 2019, In : Circulation. Genomic and precision medicine. 12, 5, p. e002510

Research output: Contribution to journalArticle

4 Scopus citations

Calmodulin mutations and life-threatening cardiac arrhythmias: Insights from the International Calmodulinopathy Registry

Crotti, L., Spazzolini, C., Tester, D. J., Ghidoni, A., Baruteau, A. E., Beckmann, B. M., Behr, E. R., Bennett, J. S., Bezzina, C. R., Bhuiyan, Z. A., Celiker, A., Cerrone, M., Dagradi, F., De Ferrari, G. M., Etheridge, S. P., Fatah, M., Garcia-Pavia, P., Al-Ghamdi, S., Hamilton, R. M., Al-Hassnan, Z. N. & 21 others, Horie, M., Jimenez-Jaimez, J., Kanter, R. J., Kaski, J. P., Kotta, M. C., Lahrouchi, N., Makita, N., Norrish, G., Odland, H. H., Ohno, S., Papagiannis, J., Parati, G., Sekarski, N., Tveten, K., Vatta, M., Webster, G., Wilde, A. A. M., Wojciak, J., George, A. L., Ackerman, M. J. & Schwartz, P. J., Sep 14 2019, In : European heart journal. 40, 35, p. 2964-2975A

Research output: Contribution to journalArticle

8 Scopus citations

Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2

Alvarado, F. J., Martijn Bos, J., Yuchi, Z., Valdivia, C. R., Hernández, J. J., Zhao, Y. T., Henderlong, D. S., Chen, Y., Booher, T. R., Marcou, C. A., Van Petegem, F., Ackerman, M. J. & Valdivia, H. H., Jan 1 2019, In : JCI Insight. 4, 7, e126544.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Cost Efficacy of α-Galactosidase A Enzyme Screening for Fabry Disease

Newman, D. B., Miranda, W. R., Matern, D., Peck, D. S., Geske, J. B., Maleszewski, J., Ommen, S. R. & Ackerman, M. J., Jan 1 2019, In : Mayo Clinic Proceedings. 94, 1, p. 84-88 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Development and Validation of a Deep-Learning Model to Screen for Hyperkalemia from the Electrocardiogram

Galloway, C. D., Valys, A. V., Shreibati, J. B., Treiman, D. L., Petterson, F. L., Gundotra, V. P., Albert, D. E., Attia, Z. I., Carter, R. E., Asirvatham, S. J., Ackerman, M. J., Noseworthy, P., Dillon, J. J. & Friedman, P. A., Jan 1 2019, In : JAMA cardiology.

Research output: Contribution to journalArticle

13 Scopus citations

Effective Use of Percutaneous Stellate Ganglion Blockade in Patients with Electrical Storm

Tian, Y., Wittwer, E. D., Kapa, S., McLeod, C. J., Xiao, P., Noseworthy, P. A., Mulpuru, S. K., Deshmukh, A. J., Lee, H. C., Ackerman, M. J., Asirvatham, S. J., Munger, T. M., Liu, X. P., Friedman, P. A. & Cha, Y. M., Sep 1 2019, In : Circulation: Arrhythmia and Electrophysiology. 12, 9

Research output: Contribution to journalArticle

2 Scopus citations

Electrophysiologic effects and outcomes of sympatholysis in patients with recurrent ventricular arrhythmia and structural heart disease

Cai, C., Dai, M. Y., Tian, Y., Zhang, P., Wittwer, E. D., Rho, R. H., Kapa, S., McLeod, C. J., Mulpuru, S., Lee, H. C., Ackerman, M. J., Asirvatham, S. J., Munger, T. M., Chen, M. L., Friedman, P. A. & Cha, Y-M., Sep 1 2019, In : Journal of cardiovascular electrophysiology. 30, 9, p. 1499-1507 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Establishment of Specialized Clinical Cardiovascular Genetics Programs: Recognizing the Need and Meeting Standards: A Scientific Statement From the American Heart Association

Ahmad, F., McNally, E. M., Ackerman, M. J., Baty, L. C., Day, S. M., Kullo, I. J., Madueme, P. C., Maron, M. S., Martinez, M. W., Salberg, L., Taylor, M. R. & Wilcox, J. E., Jun 1 2019, In : Circulation. Genomic and precision medicine. 12, 6, p. e000054

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Evaluation After Sudden Death in the Young

Gray, B., Ackerman, M. J., Semsarian, C. & Behr, E. R., Aug 1 2019, In : Circulation. Arrhythmia and electrophysiology. 12, 8, p. e007453

Research output: Contribution to journalArticle

1 Scopus citations
3 Scopus citations

Findings of Uncertain Significance and a Family History of Sudden Death: Worth the FUSs?

Ackerman, M. J. & Giudicessi, J. R., Aug 13 2019, In : Journal of the American College of Cardiology. 74, 6, p. 771-773 3 p.

Research output: Contribution to journalEditorial

Heritability in genetic heart disease: The role of genetic background

Jansweijer, J. A., Van Spaendonck-Zwarts, K. Y., Tanck, M. W. T., Peter Van Tintelen, J., Christiaans, I., Van Der Smagt, J., Vermeer, A., Bos, J. M., Moss, A. J., Swan, H., Priori, S., Rydberg, A., Tfelt-Hansen, J., Ackerman, M. J., Olivotto, I., Charron, P., Gimeno, J. R., Van Den Berg, M., Wilde, A. & Pinto, Y. M., May 1 2019, In : Open Heart. 6, 1, e000929.

Research output: Contribution to journalArticle

Open Access

Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions

Gandhi, J. K., Knudsen, T., Hill, M., Roy, B., Bachman, L., Pfannkoch-Andrews, C., Schmidt, K. N., Metko, M. M., Ackerman, M. J., Resch, Z., Pulido, J. S. & Marmorstein, A. D., Jan 1 2019, In : Stem Cells Translational Medicine.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Identification of a Novel Homozygous Multi-Exon Duplication in RYR2 among Children with Exertion-Related Unexplained Sudden Deaths in the Amish Community

Tester, D. J., Bombei, H. M., Fitzgerald, K. K., Giudicessi, J. R., Pitel, B. A., Thorland, E. C., Russell, B. G., Hamrick, S. K., Kim, C. S. J., Haglund-Turnquist, C. M., Johnsrude, C. L., Atkins, D. L., Ochoa Nunez, L. A., Law, I., Temple, J. & Ackerman, M. J., Jan 1 2019, (Accepted/In press) In : JAMA cardiology. p. E1-E6

Research output: Contribution to journalArticle

Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest

Van Der Werf, C., Lieve, K. V., Bos, J. M., Lane, C. M., Denjoy, I., Roses-Noguer, F., Aiba, T., Wada, Y., Ingles, J., Leren, I. S., Rudic, B., Schwartz, P. J., Maltret, A., Sacher, F., Skinner, J. R., Krahn, A. D., Roston, T. M., Tfelt-Hansen, J., Swan, H., Robyns, T. & 17 others, Ohno, S., Roberts, J. D., Van Den Berg, M. P., Kammeraad, J. A., Probst, V., Kannankeril, P. J., Blom, N. A., Behr, E. R., Borggrefe, M., Haugaa, K. H., Semsarian, C., Horie, M., Shimizu, W., Till, J. A., Leenhardt, A., Ackerman, M. J. & Wilde, A. A., Sep 14 2019, In : European heart journal. 40, 35, p. 2953-2961 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2 Scopus citations

International Triadin Knockout Syndrome Registry

Clemens, D. J., Tester, D. J., Giudicessi, J. R., Bos, J. M., Rohatgi, R. K., Abrams, D. J., Balaji, S., Crotti, L., Faure, J., Napolitano, C., Priori, S. G., Probst, V., Rooryck-Thambo, C., Roux-Buisson, N., Sacher, F., Schwartz, P. J., Silka, M. J., Walsh, M. A. & Ackerman, M. J., Feb 1 2019, In : Circulation. Genomic and precision medicine. 12, 2, p. e002419

Research output: Contribution to journalArticle

3 Scopus citations

Left cardiac sympathetic denervation for recurrent ventricular tachyarrhythmias in children with congenital heart disease

Bonura, E. D., Moir, C., Ackerman, M. J. & Wackel, P., Jan 1 2019, In : HeartRhythm Case Reports.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia

Lieve, K. V. V., Verhagen, J. M. A., Wei, J., Bos, J. M., van der Werf, C., Rosés i Noguer, F., Mancini, G. M. S., Guo, W., Wang, R., van den Heuvel, F., Frohn-Mulder, I. M. E., Shimizu, W., Nogami, A., Horigome, H., Roberts, J. D., Leenhardt, A., Crijns, H. J. G., Blank, A. C., Aiba, T., Wiesfeld, A. C. P. & 7 others, Blom, N. A., Sumitomo, N., Till, J., Ackerman, M. J., Chen, S. R. W., van de Laar, I. M. B. H. & Wilde, A. A. M., Feb 1 2019, In : Heart Rhythm. 16, 2, p. 220-228 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Long QT syndrome caveolin-3 mutations differentially modulate Kv4 and Cav1.2 channels to contribute to action potential prolongation

Tyan, L., Foell, J. D., Vincent, K. P., Woon, M. T., Mesquitta, W. T., Lang, D., Best, J. M., Ackerman, M. J., McCulloch, A. D., Glukhov, A. V., Balijepalli, R. C. & Kamp, T. J., Jan 1 2019, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

1 Scopus citations

Mexiletine Shortens the QT Interval in Patients With Potassium Channel-Mediated Type 2 Long QT Syndrome

Bos, J. M., Crotti, L., Rohatgi, R. K., Castelletti, S., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., May 1 2019, In : Circulation. Arrhythmia and electrophysiology. 12, 5, p. e007280

Research output: Contribution to journalArticle

7 Scopus citations

Mothers with long QT syndrome are at increased risk for fetal death: findings from a multicenter international study

Fetal LQTS Consortium, Jan 1 2019, (Accepted/In press) In : American journal of obstetrics and gynecology.

Research output: Contribution to journalArticle

Open Access

Pediatric-Onset Arrhythmogenic Cardiomyopathy: Look Right, Look Left, Look Both Ways

Ackerman, M. J. & Giudicessi, J. R., Jul 23 2019, In : Journal of the American College of Cardiology. 74, 3, p. 359-361 3 p.

Research output: Contribution to journalEditorial

Plakophilin-2 Truncation Variants in Patients Clinically Diagnosed With Catecholaminergic Polymorphic Ventricular Tachycardia and Decedents With Exercise-Associated Autopsy Negative Sudden Unexplained Death in the Young

Tester, D. J., Ackerman, J. P., Giudicessi, J. R., Ackerman, N. C., Cerrone, M., Delmar, M. & Ackerman, M. J., Jan 1 2019, In : JACC: Clinical Electrophysiology. 5, 1, p. 120-127 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

QT prolongation in patients with acute leukemia or high-risk myelodysplastic syndrome prescribed antifungal prophylaxis during chemotherapy-induced neutropenia

Barreto, J. N., Cullen, M. W., Mara, K. C., Grove, M. E., Sierzchulski, A. G., Dahl, N. J., Tosh, P. K., Dierkhising, R. A., Patnaik, M. M. & Ackerman, M. J., Jan 1 2019, In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

Shared decision making for athletes with cardiovascular disease: Practical considerations

Baggish, A. L., Ackerman, M. J., Putukian, M. & Lampert, R., Mar 1 2019, In : Current Sports Medicine Reports. 18, 3, p. 76-81 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
1 Scopus citations

Stellate ganglion block and cardiac sympathetic denervation in patients with inappropriate sinus tachycardia

Cha, Y. M., Li, X., Yang, M., Han, J., Wu, G., Kapa, S. C., McLeod, C. J., Noseworthy, P. A., Mulpuru, S. K., Asirvatham, S. J., Brady, P. A., Rho, R. H., Friedman, P. A., Lee, H. C., Tian, Y., Zhou, S., Munger, T. M., Ackerman, M. J. & Shen, W. K., Jan 1 2019, (Accepted/In press) In : Journal of cardiovascular electrophysiology.

Research output: Contribution to journalArticle

Open Access

Survival After Myectomy for Obstructive Hypertrophic Cardiomyopathy: What Causes Late Mortality?

Nguyen, A., Schaff, H. V., Nishimura, R. A., Geske, J. B., Ackerman, M. J., Bos, J. M., Dearani, J. A. & Ommen, S. R., Jan 1 2019, In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

3 Scopus citations

The Effect of Left Cardiac Sympathetic Denervation on Exercise in Patients With Long QT Syndrome

Anderson, H. N., Bos, J. M., Rohatgi, R. K. & Ackerman, M. J., Sep 1 2019, In : JACC: Clinical Electrophysiology. 5, 9, p. 1084-1090 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

The QT Interval

Giudicessi, J. R., Noseworthy, P. & Ackerman, M. J., Jun 11 2019, In : Circulation. 139, 24, p. 2711-2713 3 p.

Research output: Contribution to journalArticle

Utilization of the genome aggregation database, in silico tools, and heterologous expression patch-clamp studies to identify and demote previously published type 2 long QT syndrome: Causative variants from pathogenic to likely benign

Mattivi, C. L., Ye, D., Tester, D. J., Clemens, D. J., Zhou, W., Giudicessi, J. R. & Ackerman, M. J., Jan 1 2019, (Accepted/In press) In : Heart rhythm.

Research output: Contribution to journalArticle

2018

2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., Gillis, A. M., Granger, C. B., Hammill, S. C., Hlatky, M. A., Joglar, J. A., Kay, G. N., Matlock, D. D., Myerburg, R. J. & Page, R. L., Oct 1 2018, In : Heart Rhythm. 15, 10, p. e190-e252

Research output: Contribution to journalArticle

114 Scopus citations

2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., Gillis, A. M., Granger, C. B., Hammill, S. C., Hlatky, M. A., Joglar, J. A., Kay, G. N., Matlock, D. D., Myerburg, R. J. & Page, R. L., Oct 1 2018, In : Heart Rhythm. 15, 10, p. e73-e189

Research output: Contribution to journalArticle

58 Scopus citations

2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., Gillis, A. M., Granger, C. B., Hammill, S. C., Hlatky, M. A., Joglar, J. A., Kay, G. N., Matlock, D. D., Myerburg, R. J. & Page, R. L., Sep 25 2018, In : Circulation. 138, 13, p. e272-e391

Research output: Contribution to journalArticle

95 Scopus citations

2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., Gillis, A. M., Granger, C. B., Hammill, S. C., Hlatky, M. A., Joglar, J. A., Kay, G. N., Matlock, D. D., Myerburg, R. J. & Page, R. L., Oct 2 2018, In : Journal of the American College of Cardiology. 72, 14, p. 1677-1749 73 p.

Research output: Contribution to journalArticle

64 Scopus citations

2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary

Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., Gillis, A. M., Granger, C. B., Hammill, S. C., Hlatky, M. A., Joglar, J. A., Kay, G. N., Matlock, D. D., Myerburg, R. J. & Page, R. L., Sep 25 2018, In : Circulation. 138, 13, p. e210-e271

Research output: Contribution to journalArticle

71 Scopus citations