Michael John Ackerman, MD, PhD, FACC

  • 37409 Citations
  • 106 Scopus h-Index
1991 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk

Musa, H., Marcou, C. A., Herron, T. J., Makara, M. A., Tester, D. J., O'Connell, R. P., Rosinski, B., Guerrero-Serna, G., Milstein, M. L., Da Rocha, A. M., Ye, D., Crotti, L., Nesterenko, V. V., Castelletti, S., Torchio, M., Kotta, M. C., Dagradi, F., Antzelevitch, C., Mohler, P. J., Schwartz, P. J. & 2 others, Ackerman, M. J. & Anumonwo, J. M., Jun 2020, In : American Journal of Physiology - Heart and Circulatory Physiology. 318, 6, p. H1357-H1370

Research output: Contribution to journalArticle

An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome

Adler, A., Novelli, V., Amin, A. S., Abiusi, E., Care, M., Nannenberg, E. A., Feilotter, H., Amenta, S., Mazza, D., Bikker, H., Sturm, A. C., Garcia, J., Ackerman, M. J., Hershberger, R. E., Perez, M. V., Zareba, W., Ware, J. S., Wilde, A. A. M. & Gollob, M. H., Feb 11 2020, In : Circulation. p. 418-428 11 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition

Roberts, J. D., Asaki, S. Y., Mazzanti, A., Bos, J. M., Tuleta, I., Muir, A. R., Crotti, L., Krahn, A. D., Kutyifa, V., Shoemaker, M. B., Johnsrude, C. L., Aiba, T., Marcondes, L., Baban, A., Udupa, S., Dechert, B., Fischbach, P., Knight, L. M., Vittinghoff, E., Kukavica, D. & 39 others, Stallmeyer, B., Giudicessi, J. R., Spazzolini, C., Shimamoto, K., Tadros, R., Cadrin-Tourigny, J., Duff, H. J., Simpson, C. S., Roston, T. M., Wijeyeratne, Y. D., El Hajjaji, I., Yousif, M. D., Gula, L. J., Leong-Sit, P., Chavali, N., Landstrom, A. P., Marcus, G. M., Dittmann, S., Wilde, A. A. M., Behr, E. R., Tfelt-Hansen, J., Scheinman, M. M., Perez, M. V., Kaski, J. P., Gow, R. M., Drago, F., Aziz, P. F., Abrams, D. J., Gollob, M. H., Skinner, J. R., Shimizu, W., Kaufman, E. S., Roden, D. M., Zareba, W., Schwartz, P. J., Schulze-Bahr, E., Etheridge, S. P., Priori, S. G. & Ackerman, M. J., 2020, (Accepted/In press) In : Circulation. p. 429-439 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cardiac Magnetic Resonance Imaging Features in Hypertrophic Cardiomyopathy Diagnosed at <21 Years of Age

Bonura, E. D., Bos, J. M., Abdelsalam, M. A., Araoz, P. A., Ommen, S. R., Ackerman, M. J. & Geske, J. B., Apr 15 2020, In : American Journal of Cardiology. 125, 8, p. 1249-1255 7 p.

Research output: Contribution to journalArticle

Clinical and functional reappraisal of alleged type 5 long QT syndrome: Causative genetic variants in the KCNE1-encoded minK β-subunit

Garmany, R., Giudicessi, J. R., Ye, D., Zhou, W., Tester, D. J. & Ackerman, M. J., Jun 2020, In : Heart rhythm. 17, 6, p. 937-944 8 p.

Research output: Contribution to journalArticle

Detection of Hypertrophic Cardiomyopathy Using a Convolutional Neural Network-Enabled Electrocardiogram

Ko, W. Y., Siontis, K. C., Attia, Z. I., Carter, R. E., Kapa, S., Ommen, S. R., Demuth, S. J., Ackerman, M. J., Gersh, B. J., Arruda-Olson, A. M., Geske, J. B., Asirvatham, S. J., Lopez-Jimenez, F., Nishimura, R. A., Friedman, P. A. & Noseworthy, P. A., Feb 25 2020, In : Journal of the American College of Cardiology. 75, 7, p. 722-733 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
1 Scopus citations

Established Loss-of-Function Variants in ANK2 -Encoded Ankyrin-B Rarely Cause a concerning Cardiac Phenotype in Humans

Giudicessi, J. R. & Ackerman, M. J., Jan 1 2020, (Accepted/In press) In : Circulation: Genomic and Precision Medicine. p. 80-82 3 p.

Research output: Contribution to journalLetter

Genetic susceptibility for COVID-19–associated sudden cardiac death in African Americans

Giudicessi, J. R., Roden, D. M., Wilde, A. A. M. & Ackerman, M. J., 2020, (Accepted/In press) In : Heart rhythm.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Heart Rate Recovery after Exercise Is Associated with Arrhythmic Events in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia

Lieve, K. V. V., Dusi, V., Van Der Werf, C., Bos, J. M., Lane, C. M., Stokke, M. K., Roston, T. M., Djupsjöbacka, A., Wada, Y., Denjoy, I., Bundgaard, H., Noguer, F. R. I., Semsarian, C., Robyns, T., Hofman, N., Tanck, M. W., Van Den Berg, M. P., Kammeraad, J. A. E., Krahn, A. D., Clur, S. A. B. & 14 others, Sacher, F., Till, J., Skinner, J. R., Tfelt-Hansen, J., Probst, V., Leenhardt, A., Horie, M., Swan, H., Roberts, J. D., Sanatani, S., Haugaa, K. H., Schwartz, P. J., Ackerman, M. J. & Wilde, A. A. M., 2020, (Accepted/In press) In : Circulation: Arrhythmia and Electrophysiology. e007471.

Research output: Contribution to journalArticle

Identification of a Novel Homozygous Multi-Exon Duplication in RYR2 among Children with Exertion-Related Unexplained Sudden Deaths in the Amish Community

Tester, D. J., Bombei, H. M., Fitzgerald, K. K., Giudicessi, J. R., Pitel, B. A., Thorland, E. C., Russell, B. G., Hamrick, S. K., Kim, C. S. J., Haglund-Turnquist, C. M., Johnsrude, C. L., Atkins, D. L., Ochoa Nunez, L. A., Law, I., Temple, J. & Ackerman, M. J., Mar 2020, In : JAMA cardiology. 5, 3, p. 340-345 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Intentional nontherapy in long QT syndrome

MacIntyre, C. J., Rohatgi, R. K., Sugrue, A. M., Bos, J. M. & Ackerman, M. J., Jul 2020, In : Heart rhythm. 17, 7, p. 1147-1150 4 p.

Research output: Contribution to journalArticle

Open Access

Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2–Mediated COVID-19

Bos, J. M., Hebl, V. B., Oberg, A. L., Sun, Z., Herman, D. S., Teekakirikul, P., Seidman, J. G., Seidman, C. E., dos Remedios, C. G., Maleszewski, J. J., Schaff, H. V., Dearani, J. A., Noseworthy, P. A., Friedman, P. A., Ommen, S. R., Brozovich, F. V. & Ackerman, M. J., Jul 2020, In : Mayo Clinic proceedings. 95, 7, p. 1354-1368 15 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Prevalence and electrophysiological phenotype of rare SCN5A genetic variants identified in unexplained sudden cardiac arrest survivors

Giudicessi, J. R., Ye, D., Stutzman, M. J., Zhou, W., Tester, D. J. & Ackerman, M. J., Apr 1 2020, In : Europace. 22, 4, p. 622-631 10 p.

Research output: Contribution to journalArticle

Systematic Review of the Genetics of Sudden Unexpected Death in Epilepsy: Potential Overlap With Sudden Cardiac Death and Arrhythmia-Related Genes

Chahal, C. A. A., Salloum, M. N., Alahdab, F., Gottwald, J. A., Tester, D. J., Anwer, L. A., So, E. L., Murad, M. H., St Louis, E. K., Ackerman, M. J. & Somers, V. K., Jan 7 2020, In : Journal of the American Heart Association. 9, 1, p. e012264

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Time to Redefine the Natural History and Clinical Management of Type 1 Andersen-Tawil Syndrome?

Ackerman, M. J. & Giudicessi, J. R., Apr 21 2020, In : Journal of the American College of Cardiology. 75, 15, p. 1785-1787 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Triadin Knockout Syndrome Is Absent in a Multi-Center Molecular Autopsy Cohort of Sudden Infant Death Syndrome and Sudden Unexplained Death in the Young and Is Extremely Rare in the General Population

Clemens, D. J., Gray, B., Bagnall, R. D., Tester, D. J., Dotzler, S. M., Giudicessi, J. R., Matthews, E., Semsarian, C., Behr, E. R. & Ackerman, M. J., 2020, (Accepted/In press) In : Circulation: Genomic and Precision Medicine. p. 52-58 7 p., 002731.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations

Variant Frequency and Clinical Phenotype Call into Question the Nature of Minor, Nonsyndromic Long-QT Syndrome-Susceptibility Gene-Disease Associations

Giudicessi, J. R., Rohatgi, R. K., Tester, D. J. & Ackerman, M. J., Feb 11 2020, In : Circulation. p. 495-497 3 p.

Research output: Contribution to journalLetter

1 Scopus citations
2019

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary

Towbin, J. A., McKenna, W. J., Abrams, D. J., Ackerman, M. J., Calkins, H., Darrieux, F. C. C., Daubert, J. P., de Chillou, C., DePasquale, E. C., Desai, M. Y., Estes, N. A. M., Hua, W., Indik, J. H., Ingles, J., James, C. A., John, R. M., Judge, D. P., Keegan, R., Krahn, A. D., Link, M. S. & 10 others, Marcus, F. I., McLeod, C. J., Mestroni, L., Priori, S. G., Saffitz, J. E., Sanatani, S., Shimizu, W., van Tintelen, J. P., Wilde, A. A. M. & Zareba, W., Nov 2019, In : Heart rhythm. 16, 11, p. e373-e407

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy

Towbin, J. A., McKenna, W. J., Abrams, D. J., Ackerman, M. J., Calkins, H., Darrieux, F. C. C., Daubert, J. P., de Chillou, C., DePasquale, E. C., Desai, M. Y., Estes, N. A. M., Hua, W., Indik, J. H., Ingles, J., James, C. A., John, R. M., Judge, D. P., Keegan, R., Krahn, A. D., Link, M. S. & 10 others, Marcus, F. I., McLeod, C. J., Mestroni, L., Priori, S. G., Saffitz, J. E., Sanatani, S., Shimizu, W., van Tintelen, J. P., Wilde, A. A. M. & Zareba, W., Nov 2019, In : Heart rhythm. 16, 11, p. e301-e372

Research output: Contribution to journalArticle

Open Access
42 Scopus citations
6 Scopus citations
7 Scopus citations

Assessment and Validation of a Phenotype-Enhanced Variant Classification Framework to Promote or Demote RYR2 Missense Variants of Uncertain Significance

Giudicessi, J. R., Lieve, K. V. V., Rohatgi, R. K., Koca, F., Tester, D. J., van der Werf, C., Martijn Bos, J., Wilde, A. A. M. & Ackerman, M. J., May 1 2019, In : Circulation. Genomic and precision medicine. 12, 5, p. e002510

Research output: Contribution to journalArticle

6 Scopus citations

Calmodulin mutations and life-threatening cardiac arrhythmias: Insights from the International Calmodulinopathy Registry

Crotti, L., Spazzolini, C., Tester, D. J., Ghidoni, A., Baruteau, A. E., Beckmann, B. M., Behr, E. R., Bennett, J. S., Bezzina, C. R., Bhuiyan, Z. A., Celiker, A., Cerrone, M., Dagradi, F., De Ferrari, G. M., Etheridge, S. P., Fatah, M., Garcia-Pavia, P., Al-Ghamdi, S., Hamilton, R. M., Al-Hassnan, Z. N. & 21 others, Horie, M., Jimenez-Jaimez, J., Kanter, R. J., Kaski, J. P., Kotta, M. C., Lahrouchi, N., Makita, N., Norrish, G., Odland, H. H., Ohno, S., Papagiannis, J., Parati, G., Sekarski, N., Tveten, K., Vatta, M., Webster, G., Wilde, A. A. M., Wojciak, J., George, A. L., Ackerman, M. J. & Schwartz, P. J., Sep 14 2019, In : European heart journal. 40, 35, p. 2964-2975A

Research output: Contribution to journalArticle

14 Scopus citations

Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2

Alvarado, F. J., Martijn Bos, J., Yuchi, Z., Valdivia, C. R., Hernández, J. J., Zhao, Y. T., Henderlong, D. S., Chen, Y., Booher, T. R., Marcou, C. A., Van Petegem, F., Ackerman, M. J. & Valdivia, H. H., 2019, In : JCI Insight. 4, 7, e126544.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

Cost Efficacy of α-Galactosidase A Enzyme Screening for Fabry Disease

Newman, D. B., Miranda, W. R., Matern, D., Peck, D. S., Geske, J. B., Maleszewski, J. J., Ommen, S. R. & Ackerman, M. J., Jan 1 2019, In : Mayo Clinic Proceedings. 94, 1, p. 84-88 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Development and Validation of a Deep-Learning Model to Screen for Hyperkalemia from the Electrocardiogram

Galloway, C. D., Valys, A. V., Shreibati, J. B., Treiman, D. L., Petterson, F. L., Gundotra, V. P., Albert, D. E., Attia, Z. I., Carter, R. E., Asirvatham, S. J., Ackerman, M. J., Noseworthy, P. A., Dillon, J. J. & Friedman, P. A., May 2019, In : JAMA cardiology. 4, 5, p. 428-436 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Effective Use of Percutaneous Stellate Ganglion Blockade in Patients with Electrical Storm

Tian, Y., Wittwer, E. D., Kapa, S., McLeod, C. J., Xiao, P., Noseworthy, P. A., Mulpuru, S. K., Deshmukh, A. J., Lee, H. C., Ackerman, M. J., Asirvatham, S. J., Munger, T. M., Liu, X. P., Friedman, P. A. & Cha, Y. M., Sep 1 2019, In : Circulation: Arrhythmia and Electrophysiology. 12, 9

Research output: Contribution to journalArticle

4 Scopus citations

Electrophysiologic effects and outcomes of sympatholysis in patients with recurrent ventricular arrhythmia and structural heart disease

Cai, C., Dai, M. Y., Tian, Y., Zhang, P., Wittwer, E. D., Rho, R. H., Kapa, S., McLeod, C. J., Mulpuru, S. K., Lee, H. C., Ackerman, M. J., Asirvatham, S. J., Munger, T. M., Chen, M. L., Friedman, P. A. & Cha, Y. M., Sep 1 2019, In : Journal of cardiovascular electrophysiology. 30, 9, p. 1499-1507 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Establishment of Specialized Clinical Cardiovascular Genetics Programs: Recognizing the Need and Meeting Standards: A Scientific Statement From the American Heart Association

Ahmad, F., McNally, E. M., Ackerman, M. J., Baty, L. C., Day, S. M., Kullo, I. J., Madueme, P. C., Maron, M. S., Martinez, M. W., Salberg, L., Taylor, M. R. & Wilcox, J. E., Jun 1 2019, In : Circulation. Genomic and precision medicine. 12, 6, p. e000054

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Evaluation After Sudden Death in the Young: A Global Approach

Gray, B., Ackerman, M. J., Semsarian, C. & Behr, E. R., Aug 1 2019, In : Circulation: Arrhythmia and Electrophysiology. 12, 8, 007453.

Research output: Contribution to journalReview article

2 Scopus citations
5 Scopus citations

Findings of Uncertain Significance and a Family History of Sudden Death: Worth the FUSs?

Ackerman, M. J. & Giudicessi, J. R., Aug 13 2019, In : Journal of the American College of Cardiology. 74, 6, p. 771-773 3 p.

Research output: Contribution to journalEditorial

Heritability in genetic heart disease: The role of genetic background

Jansweijer, J. A., Van Spaendonck-Zwarts, K. Y., Tanck, M. W. T., Peter Van Tintelen, J., Christiaans, I., Van Der Smagt, J., Vermeer, A., Bos, J. M., Moss, A. J., Swan, H., Priori, S., Rydberg, A., Tfelt-Hansen, J., Ackerman, M., Olivotto, I., Charron, P., Gimeno, J. R., Van Den Berg, M., Wilde, A. & Pinto, Y. M., May 1 2019, In : Open Heart. 6, 1, e000929.

Research output: Contribution to journalArticle

Open Access

Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions

Gandhi, J. K., Knudsen, T., Hill, M., Roy, B., Bachman, L., Pfannkoch-Andrews, C., Schmidt, K. N., Metko, M. M., Ackerman, M. J., Resch, Z., Pulido, J. S. & Marmorstein, A. D., Jun 2019, In : Stem Cells Translational Medicine. 8, 6, p. 512-521 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest

Van Der Werf, C., Lieve, K. V., Bos, J. M., Lane, C. M., Denjoy, I., Roses-Noguer, F., Aiba, T., Wada, Y., Ingles, J., Leren, I. S., Rudic, B., Schwartz, P. J., Maltret, A., Sacher, F., Skinner, J. R., Krahn, A. D., Roston, T. M., Tfelt-Hansen, J., Swan, H., Robyns, T. & 17 others, Ohno, S., Roberts, J. D., Van Den Berg, M. P., Kammeraad, J. A., Probst, V., Kannankeril, P. J., Blom, N. A., Behr, E. R., Borggrefe, M., Haugaa, K. H., Semsarian, C., Horie, M., Shimizu, W., Till, J. A., Leenhardt, A., Ackerman, M. J. & Wilde, A. A., Sep 14 2019, In : European heart journal. 40, 35, p. 2953-2961 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Induced Pluripotent Stem Cell–Derived Cardiomyocytes from a Patient with MYL2-R58Q-Mediated Apical Hypertrophic Cardiomyopathy Show Hypertrophy, Myofibrillar Disarray, and Calcium Perturbations

Zhou, W., Bos, J. M., Ye, D., Tester, D. J., Hrstka, S., Maleszewski, J. J., Ommen, S. R., Nishimura, R. A., Schaff, H. V., Kim, C. S. & Ackerman, M. J., Oct 1 2019, In : Journal of cardiovascular translational research. 12, 5, p. 394-403 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

International Triadin Knockout Syndrome Registry: The Clinical Phenotype and Treatment Outcomes of Patients with Triadin Knockout Syndrome

Clemens, D. J., Tester, D. J., Giudicessi, J. R., Bos, J. M., Rohatgi, R. K., Abrams, D. J., Balaji, S., Crotti, L., Faure, J., Napolitano, C., Priori, S. G., Probst, V., Rooryck-Thambo, C., Roux-Buisson, N., Sacher, F., Schwartz, P. J., Silka, M. J., Walsh, M. A. & Ackerman, M. J., Feb 1 2019, In : Circulation: Genomic and Precision Medicine. 12, 2, p. 65-75 11 p., e002419.

Research output: Contribution to journalArticle

6 Scopus citations

Left cardiac sympathetic denervation for recurrent ventricular tachyarrhythmias in children with congenital heart disease

Bonura, E. D., Moir, C., Ackerman, M. J. & Wackel, P., Jan 1 2019, In : HeartRhythm Case Reports.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia

Lieve, K. V. V., Verhagen, J. M. A., Wei, J., Bos, J. M., van der Werf, C., Rosés i Noguer, F., Mancini, G. M. S., Guo, W., Wang, R., van den Heuvel, F., Frohn-Mulder, I. M. E., Shimizu, W., Nogami, A., Horigome, H., Roberts, J. D., Leenhardt, A., Crijns, H. J. G., Blank, A. C., Aiba, T., Wiesfeld, A. C. P. & 7 others, Blom, N. A., Sumitomo, N., Till, J., Ackerman, M. J., Chen, S. R. W., van de Laar, I. M. B. H. & Wilde, A. A. M., Feb 2019, In : Heart rhythm. 16, 2, p. 220-228 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Long QT syndrome caveolin-3 mutations differentially modulate K v 4 and Ca v 1.2 channels to contribute to action potential prolongation

Tyan, L., Foell, J. D., Vincent, K. P., Woon, M. T., Mesquitta, W. T., Lang, D., Best, J. M., Ackerman, M. J., McCulloch, A. D., Glukhov, A. V., Balijepalli, R. C. & Kamp, T. J., Mar 15 2019, In : Journal of Physiology. 597, 6, p. 1531-1551 21 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mexiletine Shortens the QT Interval in Patients With Potassium Channel-Mediated Type 2 Long QT Syndrome

Bos, J. M., Crotti, L., Rohatgi, R. K., Castelletti, S., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., May 1 2019, In : Circulation. Arrhythmia and electrophysiology. 12, 5, p. e007280

Research output: Contribution to journalArticle

10 Scopus citations

Mothers with long QT syndrome are at increased risk for fetal death: findings from a multicenter international study

Fetal LQTS Consortium, Jan 1 2019, (Accepted/In press) In : American journal of obstetrics and gynecology.

Research output: Contribution to journalArticle

2 Scopus citations

Noncardiac genetic predisposition in sudden infant death syndrome

Gray, B., Tester, D. J., Wong, L. C., Chanana, P., Jaye, A., Evans, J. M., Baruteau, A. E., Evans, M., Fleming, P., Jeffrey, I., Cohen, M., Tfelt-Hansen, J., Simpson, M. A., Ackerman, M. J. & Behr, E. R., Mar 1 2019, In : Genetics in Medicine. 21, 3, p. 641-649 9 p.

Research output: Contribution to journalArticle

3 Scopus citations