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Michael John Ackerman, MD, PhD, FACC

  • 33922 Citations
  • 101 Scopus h-Index
1991 …2020
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  • 13 Similar Profiles
Long QT Syndrome Medicine & Life Sciences
Hypertrophic Cardiomyopathy Medicine & Life Sciences
Mutation Medicine & Life Sciences
Sudden Cardiac Death Medicine & Life Sciences
Cardiac Arrhythmias Medicine & Life Sciences
Genetic Testing Medicine & Life Sciences
Channelopathies Medicine & Life Sciences
Sudden Death Medicine & Life Sciences

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Projects 2002 2020

Exercise in Genetic Cardiovascular Conditions

Day, S., Lampert, R. & Ackerman, M. J.

National Institutes of Health

2/1/15 → 1/31/20

Project: Research project

Exercise
Quality of Life
Long QT Syndrome
Sports
Patient Advocacy

Cardiac Channel Mutations in SIDS

Ackerman, M. J.

National Institutes of Health

6/7/02 → 5/31/18

Project: Research project

Sudden Infant Death
Mutation
Autonomic Nervous System
Genes
Macromolecular Substances

Research Output 1991 2019

1 Citation (Scopus)

A Novel Truncating Variant in FLNC-Encoded Filamin C May Serve as a Proarrhythmic Genetic Substrate for Arrhythmogenic Bileaflet Mitral Valve Prolapse Syndrome

Bains, S., Tester, D. J., Asirvatham, S. J., Noseworthy, P., Ackerman, M. J. & Giudicessi, J. R., Jan 1 2019, In : Mayo Clinic proceedings.

Research output: Contribution to journal › Article

Filamins
Mitral Valve Prolapse
Mothers
Exome
Ambulatory Monitoring
2 Citations (Scopus)

A pore-localizing CACNA1C-E1115K missense mutation, identified in a patient with idiopathic QT prolongation, bradycardia, and autism spectrum disorder, converts the L-type calcium channel into a hybrid nonselective monovalent cation channel

Ye, D., Tester, D. J., Zhou, W., Papagiannis, J. & Ackerman, M. J., Feb 1 2019, In : Heart Rhythm. 16, 2, p. 270-278 9 p.

Research output: Contribution to journal › Article

Monovalent Cations
L-Type Calcium Channels
Missense Mutation
Nifedipine
Bradycardia

Assessment and Validation of a Phenotype-Enhanced Variant Classification Framework to Promote or Demote RYR2 Missense Variants of Uncertain Significance

Giudicessi, J. R., Lieve, K. V. V., Rohatgi, R. K., Koca, F., Tester, D. J., van der Werf, C., Martijn Bos, J., Wilde, A. A. M. & Ackerman, M. J., May 1 2019, In : Circulation. Genomic and precision medicine. 12, 5, p. e002510

Research output: Contribution to journal › Article

Phenotype
Genetic Testing
Multicenter Studies
Retrospective Studies
Guidelines
1 Citation (Scopus)

Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2

Alvarado, F. J., Bos, J. M., Yuchi, Z., Valdivia, C. R., Hernandez, J. J., Zhao, Y. T., Henderlong, D. S., Chen, Y., Booher, T. R., Marcou, C. A., Van Petegem, F., Ackerman, M. J. & Valdivia, H. H., Mar 5 2019, In : JCI insight. 5

Research output: Contribution to journal › Article

Ryanodine Receptor Calcium Release Channel
Cardiomegaly
Cardiac Arrhythmias
Mutation
Hypertrophic Cardiomyopathy

Characterization of the CACNA1C-R518C Missense Mutation in the Pathobiology of Long-QT Syndrome Using Human Induced Pluripotent Stem Cell Cardiomyocytes Shows Action Potential Prolongation and L-Type Calcium Channel Perturbation

Estes, S. I., Ye, D., Zhou, W., Dotzler, S. M., Tester, D. J., Bos, J. M., Kim, C. S. J. & Ackerman, M. J., Aug 1 2019, In : Circulation. Genomic and precision medicine. 12, 8, p. e002534

Research output: Contribution to journal › Article

Long QT Syndrome
Induced Pluripotent Stem Cells
L-Type Calcium Channels
Missense Mutation
Cardiac Myocytes