Michael John Ackerman, MD, PhD, FACC

  • 35918 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2012

Drowning

Tester, D. J. & Ackerman, M. J., Aug 23 2012, In : New England Journal of Medicine. 367, 8, 1 p.

Research output: Contribution to journalLetter

1 Scopus citations

Epinephrine test for sudden cardiac death - Is it too early?

Bos, J. M. & Ackerman, M. J., Dec 1 2012, In : Nature Reviews Cardiology. 9, 12, p. 675-676 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Erratum: HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies (Europace (2011) 13 (1077-1109) DOI: 10.1093/europace/eur245)

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 1 others, Zipes, D. P., Feb 1 2012, In : Europace. 14, 2, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K+ permeation

Burgess, D. E., Bartos, D. C., Reloj, A. R., Campbell, K. S., Johnson, J. N., Tester, D. J., Ackerman, M. J., Fressart, V., Denjoy, I., Guicheney, P., Moss, A. J., Ohno, S., Horie, M. & Delisle, B. P., Nov 13 2012, In : Biochemistry. 51, 45, p. 9076-9085 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction

Xi, Y., Ai, T., De Lange, E., Li, Z., Wu, G., Brunelli, L., Kyle, W. B., Turker, I., Cheng, J., Ackerman, M. J., Kimura, A., Weiss, J. N., Qu, Z., Kim, J. J., Faulkner, G. & Vatta, M., Oct 1 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 5, p. 1017-1026 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: Interaction of trafficking and gating

Balijepalli, S. Y., Lim, E., Concannon, S. P., Chew, C. L., Holzem, K. E., Tester, D. J., Ackerman, M. J., Delisle, B. P., Balijepalli, R. C. & January, C. T., Dec 11 2012, In : Circulation. 126, 24, p. 2809-2818 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations

Purevjav, E., Arimura, T., Augustin, S., Huby, A. C., Takagi, K., Nunoda, S., Kearney, D. L., Taylor, M. D., Terasaki, F., Bos, J. M., Ommen, S. R., Shibata, H., Takahashi, M., Itoh-satoh, M., Mckenna, W. J., Murphy, R. T., Labeit, S., Yamanaka, Y., Machida, N., Park, J. E. & 6 others, Alexander, P. M. A., Weintraub, R. G., Kitaura, Y., Ackerman, M. J., Kimura, A. & Towbin, J. A., May 1 2012, In : Human molecular genetics. 21, 9, p. 2039-2053 15 p., dds022.

Research output: Contribution to journalArticle

49 Scopus citations

Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: Implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome

Barsheshet, A., Goldenberg, I., O-Uchi, J., Moss, A. J., Jons, C., Shimizu, W., Wilde, A. A., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Ackerman, M. J., Cypress, M., Gray, D. A., Hofman, N., Kanters, J. K., Kaufman, E. S., Platonov, P. G., Qi, M., Towbin, J. A. & 2 others, Vincent, G. M. & Lopes, C. M., Apr 24 2012, In : Circulation. 125, 16, p. 1988-1996 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: Higher recurrence of events under metoprolol

Chockalingam, P., Crotti, L., Girardengo, G., Johnson, J. N., Harris, K. M., Van Der Heijden, J. F., Hauer, R. N. W., Beckmann, B. M., Spazzolini, C., Rordorf, R., Rydberg, A., Clur, S. A. B., Fischer, M., Van Den Heuvel, F., Kääb, S., Blom, N. A., Ackerman, M. J., Schwartz, P. J. & Wilde, A. A. M., Nov 13 2012, In : Journal of the American College of Cardiology. 60, 20, p. 2092-2099 8 p.

Research output: Contribution to journalArticle

118 Scopus citations

Novel Mutations in the KCND3-Encoded Kv4.3 K+ Channel Associated with Autopsy-Negative Sudden Unexplained Death

Giudicessi, J. R., Ye, D., Kritzberger, C. J., Nesterenko, V. V., Tester, D. J., Antzelevitch, C. & Ackerman, M. J., Jun 1 2012, In : Human mutation. 33, 6, p. 989-997 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pediatric sudden cardiac arrest

Campbell, R., Berger, S., Ackerman, M. J., Morrow, W. R., Jenkins, K., Minich, L. L. A., Rosenthal, G. L., Snyder, C. S. & Twedell, J., Apr 2012, In : Pediatrics. 129, 4, p. e1094-e1102

Research output: Contribution to journalReview article

29 Scopus citations

Phylogenetic and physicochemical analyses enhance the classification of rare nonsynonymous single nucleotide variants in type 1 and 2 long-QT syndrome

Giudicessi, J. R., Kapplinger, J. D., Tester, D. J., Alders, M., Salisbury, B. A., Wilde, A. A. M. & Ackerman, M. J., Oct 1 2012, In : Circulation: Cardiovascular Genetics. 5, 5, p. 519-528 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Potassium-channel mutations and cardiac arrhythmias - Diagnosis and therapy

Giudicessi, J. R. & Ackerman, M. J., Jun 1 2012, In : Nature Reviews Cardiology. 9, 6, p. 319-332 14 p.

Research output: Contribution to journalReview article

58 Scopus citations

Potential depot medroxyprogesterone acetate-triggered torsades de pointes in a case of congenital type 2 long QT syndrome

Giudicessi, J. R., Brost, B. C., Traynor, K. D. & Ackerman, M. J., Jul 1 2012, In : Heart rhythm. 9, 7, p. 1143-1147 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: A novel mechanism of drug action

Beyder, A., Strege, P. R., Reyes, S., Bernard, C. E., Terzic, A., Makielski, J., Ackerman, M. J. & Farrugia, G., Jun 5 2012, In : Circulation. 125, 22, p. 2698-2706 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells

Strege, P., Beyder, A., Bernard, C., Crespo-Diaz, R., Behfar, A., Terzic, A., Ackerman, M. & Farrugia, G., Jan 1 2012, In : Channels. 6, 6, p. 457-462 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Repeat long QT syndrome genetic testing of phenotype-positive cases: Prevalence and etiology of detection misses

Medlock, M. M., Tester, D. J., Will, M. L., Bos, J. M. & Ackerman, M. J., Dec 1 2012, In : Heart rhythm. 9, 12, p. 1977-1982 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Restricting sports for athletes with heart disease: Are we saving lives, avoiding lawsuits, or just promoting obesity and sedentary living?

Vaseghi, M., Ackerman, M. J. & Mandapati, R., Mar 2012, In : Pediatric Cardiology. 33, 3, p. 407-416 10 p.

Research output: Contribution to journalReview article

14 Scopus citations

Spectrum and prevalence of mutations involving BrS1- Through BrS12-susceptibility genes in a cohort of unrelated patients referred for brugada syndrome genetic testing: Implications for genetic testing

Crotti, L., Marcou, C. A., Tester, D. J., Castelletti, S., Giudicessi, J. R., Torchio, M., Medeiros-Domingo, A., Simone, S., Will, M. L., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., Oct 9 2012, In : Journal of the American College of Cardiology. 60, 15, p. 1410-1418 9 p.

Research output: Contribution to journalArticle

130 Scopus citations

Surprise, surprise: Idiopathic, isolated complete atrioventricular block may be heritable

Cannon, B. C. & Ackerman, M. J., Sep 18 2012, In : Circulation. 126, 12, p. 1434-1435 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations

TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy

Bos, J. M., Subramaniam, M., Hawse, J. R., Christiaans, I., Rajamannan, N. M., Maleszewski, J. J., Edwards, W. D., Wilde, A. A. M., Spelsberg, T. C. & Ackerman, M. J., Jun 1 2012, In : Journal of cellular biochemistry. 113, 6, p. 1896-1903 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

The molecular autopsy: Should the evaluation continue after the funeral?

Tester, D. J. & Ackerman, M. J., Mar 1 2012, In : Pediatric Cardiology. 33, 3, p. 461-470 10 p.

Research output: Contribution to journalReview article

64 Scopus citations

The molecular autopsy: An indispensable step following sudden cardiac death in the young?

Boczek, N. J., Tester, D. J. & Ackerman, M. J., Sep 1 2012, In : Herzschrittmachertherapie und Elektrophysiologie. 23, 3, p. 167-173 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome

Goldenberg, I., Thottathil, P., Lopes, C. M., Moss, A. J., McNitt, S., Jin, O. U., Robinson, J. L., Zareba, W., Ackerman, M. J., Kaufman, E. S., Towbin, J. A., Vincent, M. & Barsheshet, A., Jan 1 2012, In : Heart rhythm. 9, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Truncations of titin causing dilated cardiomyopathy

Herman, D. S., Lam, L., Taylor, M. R. G., Wang, L., Teekakirikul, P., Christodoulou, D., Conner, L., DePalma, S. R., McDonough, B., Sparks, E., Teodorescu, D. L., Cirino, A. L., Banner, N. R., Pennell, D. J., Graw, S., Merlo, M., Di Lenarda, A., Sinagra, G., Bos, J. M., Ackerman, M. J. & 9 others, Mitchell, R. N., Murry, C. E., Lakdawala, N. K., Ho, C. Y., Barton, P. J. R., Cook, S. A., Mestroni, L., Seidman, J. G. & Seidman, C. E., Feb 16 2012, In : New England Journal of Medicine. 366, 7, p. 619-628 10 p.

Research output: Contribution to journalArticle

600 Scopus citations

Variants in the 3′ untranslated region of the KCNQ1-encoded K v7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner

Amin, A. S., Giudicessi, J. R., Tijsen, A. J., Spanjaart, A. M., Reckman, Y. J., Klemens, C. A., Tanck, M. W., Kapplinger, J. D., Hofman, N., Sinner, M. F., Mller, M., Wijnen, W. J., Tan, H. L., Bezzina, C. R., Creemers, E. E., Wilde, A. A. M., Ackerman, M. J. & Pinto, Y. M., Mar 1 2012, In : European heart journal. 33, 6, p. 714-723 10 p.

Research output: Contribution to journalArticle

99 Scopus citations
2011

Anesthetic management of patients with Brugada syndrome: A case series and literature review

Kloesel, B., Ackerman, M. J., Sprung, J., Narr, B. J. & Weingarten, T. N., Sep 1 2011, In : Canadian Journal of Anesthesia. 58, 9, p. 824-836 13 p.

Research output: Contribution to journalReview article

36 Scopus citations

Clinical spectrum in a family with tropomyosin-mediated hypertrophic cardiomyopathy and sudden death in childhood

Makhoul, M., Ackerman, M. J., Atkins, D. L. & Law, I. H., Feb 1 2011, In : Pediatric Cardiology. 32, 2, p. 215-220 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice

Van Oort, R. J., Garbino, A., Wang, W., Dixit, S. S., Landstrom, A. P., Gaur, N., De Almeida, A. C., Skapura, D. G., Rudy, Y., Burns, A. R., Ackerman, M. J. & Wehrens, X. H. T., Mar 8 2011, In : Circulation. 123, 9, p. 979-988 10 p.

Research output: Contribution to journalArticle

149 Scopus citations

Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia- associated mutations from background genetic noise

Kapplinger, J. D., Landstrom, A. P., Salisbury, B. A., Callis, T. E., Pollevick, G. D., Tester, D. J., Cox, M. G. P. J., Bhuiyan, Z., Bikker, H., Wiesfeld, A. C. P., Hauer, R. N. W., Van Tintelen, J. P., Jongbloed, J. D. H., Calkins, H., Judge, D. P., Wilde, A. A. M. & Ackerman, M. J., Jun 7 2011, In : Journal of the American College of Cardiology. 57, 23, p. 2317-2327 11 p.

Research output: Contribution to journalArticle

197 Scopus citations

Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch

Waddell, L. B., Lemckert, F. A., Zheng, X. F., Tran, J., Evesson, F. J., Hawkes, J. M., Lek, A., Street, N. E., Lin, P., Clarke, N. F., Landstrom, A. P., Ackerman, M. J., Weisleder, N., Ma, J., North, K. N. & Cooper, S. T., Apr 1 2011, In : Journal of Neuropathology and Experimental Neurology. 70, 4, p. 302-313 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Electrocardiographic and oximetric changes during partial complex and generalized seizures

Moseley, B. D., Wirrell, E. C., Nickels, K., Johnson, J. N., Ackerman, M. J. & Britton, J., Aug 1 2011, In : Epilepsy Research. 95, 3, p. 237-245 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Electrocardiographic changes and arrhythmias following percutaneous atrial septal defect and patent foramen ovale device closure

Johnson, J. N., Marquardt, M. L., Ackerman, M. J., Asirvatham, S. J., Reeder, G. S., Cabalka, A. K., Cetta, F. & Hagler, D. J., Aug 1 2011, In : Catheterization and Cardiovascular Interventions. 78, 2, p. 254-261 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Genetic testing for potentially lethal, highly treatable inherited cardiomyopathies/channelopathies in clinical practice

Tester, D. J. & Ackerman, M. J., Mar 8 2011, In : Circulation. 123, 9, p. 1021-1037 17 p.

Research output: Contribution to journalArticle

142 Scopus citations

Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome

Barsheshet, A., Peterson, D. R., Moss, A. J., Schwartz, P. J., Kaufman, E. S., McNitt, S., Polonsky, S., Buber, J., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Towbin, J. A., Vincent, G. M., Zhang, L. & Goldenberg, I., Aug 1 2011, In : Heart rhythm. 8, 8, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Holter monitoring in the evaluation of congenital long QT syndrome

Mauriello, D. A., Johnson, J. N. & Ackerman, M. J., Sep 1 2011, In : PACE - Pacing and Clinical Electrophysiology. 34, 9, p. 1100-1104 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 2 others, Zipes, D. P. & Olson, S., Aug 2011, In : Europace. 13, 8, p. 1077-1109 33 p.

Research output: Contribution to journalArticle

436 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA)

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 1 others, Zipes, D. P., Aug 1 2011, In : Heart rhythm. 8, 8, p. 1308-1339 32 p.

Research output: Contribution to journalArticle

602 Scopus citations

HRS policy statement: Clinical cardiac electrophysiology fellowship curriculum: Update 2011

Link, M. S., Exner, D. V., Anderson, M., Ackerman, M., Al-Ahmad, A., Knight, B. P., Markowitz, S. M., Kaufman, E. S., Haines, D., Asirvatham, S. J., Callans, D. J., Mounsey, J. P., Bogun, F., Narayan, S. M., Krahn, A. D., Mittal, S., Singh, J., Fisher, J. D. & Chugh, S. S., Aug 1 2011, In : Heart rhythm. 8, 8, p. 1340-1356 17 p.

Research output: Contribution to journalArticle

9 Scopus citations

Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling

Landstrom, A. P., Kellen, C. A., Dixit, S. S., Van Oort, R. J., Garbino, A., Weisleder, N., Ma, J., Wehrens, X. H. T. & Ackerman, M. J., Mar 1 2011, In : Circulation: Heart Failure. 4, 2, p. 214-223 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Left cardiac sympathetic denervation in a pediatric patient with hypertrophic cardiomyopathy and recurrent ventricular fibrillation

Johnson, J. N., Harris, K. M., Moir, C., Lau, Y. R. & Ackerman, M. J., Oct 1 2011, In : Heart rhythm. 8, 10, p. 1591-1594 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Left ventricular noncompaction syndrome masquerading or misdiagnosed as congenital long QT syndrome: Remember QT prolongation does not equal long QT syndrome

Coleman, M. A., Bos, J. M., Phillips, S. D., Souza, J. J. & Ackerman, M. J., Sep 1 2011, In : Congenital Heart Disease. 6, 5, p. 492-498 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss-of-function mutations in the KCNJ8-Encoded Kir6.1 KATP channel and sudden infant death syndrome

Tester, D. J., Tan, B. H., Medeiros-Domingo, A., Song, C., Makielski, J. C. & Ackerman, M. J., Oct 1 2011, In : Circulation: Cardiovascular Genetics. 4, 5, p. 510-515 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations

Olivotto, I., Girolami, F., Sciagr, R., Ackerman, M. J., Sotgia, B., Bos, J. M., Nistri, S., Sgalambro, A., Grifoni, C., Torricelli, F., Camici, P. G. & Cecchi, F., Aug 16 2011, In : Journal of the American College of Cardiology. 58, 8, p. 839-848 10 p.

Research output: Contribution to journalArticle

85 Scopus citations

Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome

Migdalovich, D., Moss, A. J., Lopes, C. M., Costa, J., Ouellet, G., Barsheshet, A., McNitt, S., Polonsky, S., Robinson, J. L., Zareba, W., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Platonov, P. G., Shimizu, W., Towbin, J. A., Vincent, G. M., Wilde, A. A. M. & Goldenberg, I., Oct 2011, In : Heart rhythm. 8, 10, p. 1537-1543 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: Summary of the literature and implications for genetic testing

Landstrom, A. P., Adekola, B. A., Bos, J. M., Ommen, S. R. & Ackerman, M. J., Jan 1 2011, In : American Heart Journal. 161, 1, p. 165-171 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Prevalence and clinical correlates of QT prolongation in patients with hypertrophic cardiomyopathy

Johnson, J. N., Grifoni, C., Bos, J. M., Saber-Ayad, M., Ommen, S. R., Nistri, S., Cecchi, F., Olivotto, I. & Ackerman, M. J., May 1 2011, In : European heart journal. 32, 9, p. 1114-1120 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

QTc values among children and adolescents presenting to the emergency department

Van Dorn, C. S., Johnson, J. N., Taggart, N. W., Thorkelson, L. & Ackerman, M. J., Dec 2011, In : Pediatrics. 128, 6, p. e1395-e1401

Research output: Contribution to journalArticle

31 Scopus citations

R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation

Bartos, D. C., Duchatelet, S., Burgess, D. E., Klug, D., Denjoy, I., Peat, R., Lupoglazoff, J. M., Fressart, V., Berthet, M., Ackerman, M. J., January, C. T., Guicheney, P. & Delisle, B. P., Jan 2011, In : Heart rhythm. 8, 1, p. 48-55 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Risk factors for recurrent syncope and subsequent fatal or near-fatal events in children and adolescents with long QT syndrome

Liu, J. F., Jons, C., Moss, A. J., McNitt, S., Peterson, D. R., Qi, M., Zareba, W., Robinson, J. L., Barsheshet, A., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J., Vincent, M., Zhang, L. & Goldenberg, I., Feb 22 2011, In : Journal of the American College of Cardiology. 57, 8, p. 941-950 10 p.

Research output: Contribution to journalArticle

81 Scopus citations