Michael John Ackerman, MD, PhD, FACC

  • 37462 Citations
  • 106 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2013

The long QT syndrome: A transatlantic clinical approach to diagnosis and therapy

Schwartz, P. J. & Ackerman, M. J., Oct 21 2013, In : European heart journal. 34, 40, p. 3109-3116 8 p.

Research output: Contribution to journalReview article

152 Scopus citations

Treatment and prevention modalities

Powell, B. D., Shen, W. K., Ackerman, M. J. & Gussak, I., Jan 1 2013, In : Unknown Journal. p. 494-496 3 p.

Research output: Contribution to journalArticle

2012

A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation

Parvatiyar, M. S., Landstrom, A. P., Figueiredo-Freitas, C., Potter, J. D., Ackerman, M. J. & Pinto, J. R., Sep 14 2012, In : Journal of Biological Chemistry. 287, 38, p. 31845-31855 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

A novel disease gene for Brugada syndrome: Sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5

Ishikawa, T., Sato, A., Marcou, C. A., Tester, D. J., Ackerman, M. J., Crotti, L., Schwartz, P. J., On, Y. K., Park, J. E., Nakamura, K., Hiraoka, M., Nakazawa, K., Sakurada, H., Arimura, T., Makita, N. & Kimura, A., Dec 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 6, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Nav1.5 and Kv4.3 channel currents

Hu, D., Barajas-Martínez, H., Medeiros-Domingo, A., Crotti, L., Veltmann, C., Schimpf, R., Urrutia, J., Alday, A., Casis, O., Pfeiffer, R., Burashnikov, E., Caceres, G., Tester, D. J., Wolpert, C., Borggrefe, M., Schwartz, P., Ackerman, M. J. & Antzelevitch, C., May 1 2012, In : Heart rhythm. 9, 5, p. 760-769 10 p.

Research output: Contribution to journalArticle

78 Scopus citations
25 Scopus citations

Call for a sudden cardiac death registry: Should reporting of sudden cardiac death be mandatory?

Campbell, R. M., Berger, S., Ackerman, M. J. & Batra, A. S., Mar 1 2012, In : Pediatric Cardiology. 33, 3, p. 471-473 3 p.

Research output: Contribution to journalReview article

2 Scopus citations

Cardiac channel molecular autopsy: Insights from 173 consecutive cases of autopsy-negative sudden unexplained death referred for postmortem genetic testing

Tester, D. J., Medeiros-Domingo, A., Will, M. L., Haglund, C. M. & Ackerman, M. J., Jun 2012, In : Mayo Clinic proceedings. 87, 6, p. 524-539 16 p.

Research output: Contribution to journalArticle

154 Scopus citations

Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome

Costa, J., Lopes, C. M., Barsheshet, A., Moss, A. J., Migdalovich, D., Ouellet, G., McNitt, S., Polonsky, S., Robinson, J. L., Zareba, W., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Platonov, P. G., Shimizu, W., Towbin, J. A., Vincent, G. M., Wilde, A. A. M. & Goldenberg, I., Jun 1 2012, In : Heart rhythm. 9, 6, p. 892-898 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Competitive sports participation in athletes with congenital long QT syndrome

Johnson, J. N. & Ackerman, M. J., Aug 22 2012, In : JAMA - Journal of the American Medical Association. 308, 8, p. 764-765 2 p.

Research output: Contribution to journalLetter

64 Scopus citations

Concealed long QT syndrome and intractable partial epilepsy: A case report

Anderson, J. H., Bos, J. M., Meyer, F. B., Cascino, G. D. & Ackerman, M. J., Nov 2012, In : Mayo Clinic proceedings. 87, 11, p. 1128-1131 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Congenital type 1 long QT syndrome unmasked by a highly caffeinated energy drink

Dufendach, K. A., Horner, J. M., Cannon, B. C. & Ackerman, M. J., Feb 1 2012, In : Heart rhythm. 9, 2, p. 285-288 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death

Van Norstrand, D. W., Asimaki, A., Rubinos, C., Dolmatova, E., Srinivas, M., Tester, D. J., Saffitz, J. E., Duffy, H. S. & Ackerman, M. J., Jan 24 2012, In : Circulation. 125, 3, p. 474-481 8 p.

Research output: Contribution to journalReview article

57 Scopus citations

Considerations on safety concerns about citalopram prescribing

Sheeler, R. D., Ackerman, M. J., Richelson, E., Nelson, T. K., Staab, J. P., Tangalos, E. G., Dieser, L. M. & Cunningham, J. L., Nov 2012, In : Mayo Clinic proceedings. 87, 11, p. 1042-1045 4 p.

Research output: Contribution to journalShort survey

20 Scopus citations

Denervation videoscopic left cardiac sympathetic denervation for patients with recurrent ventricular fibrillation/malignant ventricular arrhythmia syndromes besides congenital long-QT syndrome

Coleman, M. A., Bos, J. M., Johnson, J. N., Owen, H. J., Deschamps, C., Moir, C. & Ackerman, M. J., Oct 11 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 4, p. 782-788 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Drowning

Tester, D. J. & Ackerman, M. J., Aug 23 2012, In : New England Journal of Medicine. 367, 8, 1 p.

Research output: Contribution to journalLetter

1 Scopus citations

Epinephrine test for sudden cardiac death - Is it too early?

Bos, J. M. & Ackerman, M. J., Dec 1 2012, In : Nature Reviews Cardiology. 9, 12, p. 675-676 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Erratum: HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies (Europace (2011) 13 (1077-1109) DOI: 10.1093/europace/eur245)

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 1 others, Zipes, D. P., Feb 1 2012, In : Europace. 14, 2, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K+ permeation

Burgess, D. E., Bartos, D. C., Reloj, A. R., Campbell, K. S., Johnson, J. N., Tester, D. J., Ackerman, M. J., Fressart, V., Denjoy, I., Guicheney, P., Moss, A. J., Ohno, S., Horie, M. & Delisle, B. P., Nov 13 2012, In : Biochemistry. 51, 45, p. 9076-9085 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction

Xi, Y., Ai, T., De Lange, E., Li, Z., Wu, G., Brunelli, L., Kyle, W. B., Turker, I., Cheng, J., Ackerman, M. J., Kimura, A., Weiss, J. N., Qu, Z., Kim, J. J., Faulkner, G. & Vatta, M., Oct 1 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 5, p. 1017-1026 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: Interaction of trafficking and gating

Balijepalli, S. Y., Lim, E., Concannon, S. P., Chew, C. L., Holzem, K. E., Tester, D. J., Ackerman, M. J., Delisle, B. P., Balijepalli, R. C. & January, C. T., Dec 11 2012, In : Circulation. 126, 24, p. 2809-2818 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations

Purevjav, E., Arimura, T., Augustin, S., Huby, A. C., Takagi, K., Nunoda, S., Kearney, D. L., Taylor, M. D., Terasaki, F., Bos, J. M., Ommen, S. R., Shibata, H., Takahashi, M., Itoh-satoh, M., Mckenna, W. J., Murphy, R. T., Labeit, S., Yamanaka, Y., Machida, N., Park, J. E. & 6 others, Alexander, P. M. A., Weintraub, R. G., Kitaura, Y., Ackerman, M. J., Kimura, A. & Towbin, J. A., May 2012, In : Human molecular genetics. 21, 9, p. 2039-2053 15 p., dds022.

Research output: Contribution to journalArticle

49 Scopus citations

Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: Implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome

Barsheshet, A., Goldenberg, I., O-Uchi, J., Moss, A. J., Jons, C., Shimizu, W., Wilde, A. A., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Ackerman, M. J., Cypress, M., Gray, D. A., Hofman, N., Kanters, J. K., Kaufman, E. S., Platonov, P. G., Qi, M., Towbin, J. A. & 2 others, Vincent, G. M. & Lopes, C. M., Apr 24 2012, In : Circulation. 125, 16, p. 1988-1996 9 p.

Research output: Contribution to journalArticle

119 Scopus citations

Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: Higher recurrence of events under metoprolol

Chockalingam, P., Crotti, L., Girardengo, G., Johnson, J. N., Harris, K. M., Van Der Heijden, J. F., Hauer, R. N. W., Beckmann, B. M., Spazzolini, C., Rordorf, R., Rydberg, A., Clur, S. A. B., Fischer, M., Van Den Heuvel, F., Kääb, S., Blom, N. A., Ackerman, M. J., Schwartz, P. J. & Wilde, A. A. M., Nov 13 2012, In : Journal of the American College of Cardiology. 60, 20, p. 2092-2099 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

Novel Mutations in the KCND3-Encoded Kv4.3 K+ Channel Associated with Autopsy-Negative Sudden Unexplained Death

Giudicessi, J. R., Ye, D., Kritzberger, C. J., Nesterenko, V. V., Tester, D. J., Antzelevitch, C. & Ackerman, M. J., Jun 1 2012, In : Human mutation. 33, 6, p. 989-997 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pediatric sudden cardiac arrest

Campbell, R., Berger, S., Ackerman, M. J., Morrow, W. R., Jenkins, K., Minich, L. L. A., Rosenthal, G. L., Snyder, C. S. & Twedell, J., Apr 2012, In : Pediatrics. 129, 4, p. e1094-e1102

Research output: Contribution to journalReview article

31 Scopus citations

Phylogenetic and physicochemical analyses enhance the classification of rare nonsynonymous single nucleotide variants in type 1 and 2 long-QT syndrome

Giudicessi, J. R., Kapplinger, J. D., Tester, D. J., Alders, M., Salisbury, B. A., Wilde, A. A. M. & Ackerman, M. J., Oct 1 2012, In : Circulation: Cardiovascular Genetics. 5, 5, p. 519-528 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Potassium-channel mutations and cardiac arrhythmias - Diagnosis and therapy

Giudicessi, J. R. & Ackerman, M. J., Jun 1 2012, In : Nature Reviews Cardiology. 9, 6, p. 319-332 14 p.

Research output: Contribution to journalReview article

58 Scopus citations

Potential depot medroxyprogesterone acetate-triggered torsades de pointes in a case of congenital type 2 long QT syndrome

Giudicessi, J. R., Brost, B. C., Traynor, K. D. & Ackerman, M. J., Jul 1 2012, In : Heart rhythm. 9, 7, p. 1143-1147 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: A novel mechanism of drug action

Beyder, A., Strege, P. R., Reyes, S., Bernard, C. E., Terzic, A., Makielski, J., Ackerman, M. J. & Farrugia, G., Jun 5 2012, In : Circulation. 125, 22, p. 2698-2706 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells

Strege, P., Beyder, A., Bernard, C., Crespo-Diaz, R., Behfar, A., Terzic, A., Ackerman, M. & Farrugia, G., Jan 1 2012, In : Channels. 6, 6, p. 457-462 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Repeat long QT syndrome genetic testing of phenotype-positive cases: Prevalence and etiology of detection misses

Medlock, M. M., Tester, D. J., Will, M. L., Bos, J. M. & Ackerman, M. J., Dec 1 2012, In : Heart rhythm. 9, 12, p. 1977-1982 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Restricting sports for athletes with heart disease: Are we saving lives, avoiding lawsuits, or just promoting obesity and sedentary living?

Vaseghi, M., Ackerman, M. J. & Mandapati, R., Mar 2012, In : Pediatric Cardiology. 33, 3, p. 407-416 10 p.

Research output: Contribution to journalReview article

14 Scopus citations

Spectrum and prevalence of mutations involving BrS1- Through BrS12-susceptibility genes in a cohort of unrelated patients referred for brugada syndrome genetic testing: Implications for genetic testing

Crotti, L., Marcou, C. A., Tester, D. J., Castelletti, S., Giudicessi, J. R., Torchio, M., Medeiros-Domingo, A., Simone, S., Will, M. L., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., Oct 9 2012, In : Journal of the American College of Cardiology. 60, 15, p. 1410-1418 9 p.

Research output: Contribution to journalArticle

131 Scopus citations

Surprise, surprise: Idiopathic, isolated complete atrioventricular block may be heritable

Cannon, B. C. & Ackerman, M. J., Sep 18 2012, In : Circulation. 126, 12, p. 1434-1435 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations

TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy

Bos, J. M., Subramaniam, M., Hawse, J. R., Christiaans, I., Rajamannan, N. M., Maleszewski, J. J., Edwards, W. D., Wilde, A. A. M., Spelsberg, T. C. & Ackerman, M. J., Jun 1 2012, In : Journal of cellular biochemistry. 113, 6, p. 1896-1903 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

The molecular autopsy: An indispensable step following sudden cardiac death in the young?

Boczek, N. J., Tester, D. J. & Ackerman, M. J., Sep 1 2012, In : Herzschrittmachertherapie und Elektrophysiologie. 23, 3, p. 167-173 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

The molecular autopsy: Should the evaluation continue after the funeral?

Tester, D. J. & Ackerman, M. J., Mar 1 2012, In : Pediatric Cardiology. 33, 3, p. 461-470 10 p.

Research output: Contribution to journalReview article

64 Scopus citations

Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome

Goldenberg, I., Thottathil, P., Lopes, C. M., Moss, A. J., McNitt, S., Jin, O. U., Robinson, J. L., Zareba, W., Ackerman, M. J., Kaufman, E. S., Towbin, J. A., Vincent, M. & Barsheshet, A., Jan 1 2012, In : Heart rhythm. 9, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Truncations of titin causing dilated cardiomyopathy

Herman, D. S., Lam, L., Taylor, M. R. G., Wang, L., Teekakirikul, P., Christodoulou, D., Conner, L., DePalma, S. R., McDonough, B., Sparks, E., Teodorescu, D. L., Cirino, A. L., Banner, N. R., Pennell, D. J., Graw, S., Merlo, M., Di Lenarda, A., Sinagra, G., Bos, J. M., Ackerman, M. J. & 9 others, Mitchell, R. N., Murry, C. E., Lakdawala, N. K., Ho, C. Y., Barton, P. J. R., Cook, S. A., Mestroni, L., Seidman, J. G. & Seidman, C. E., Feb 16 2012, In : New England Journal of Medicine. 366, 7, p. 619-628 10 p.

Research output: Contribution to journalArticle

624 Scopus citations

Variants in the 3′ untranslated region of the KCNQ1-encoded K v7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner

Amin, A. S., Giudicessi, J. R., Tijsen, A. J., Spanjaart, A. M., Reckman, Y. J., Klemens, C. A., Tanck, M. W., Kapplinger, J. D., Hofman, N., Sinner, M. F., Mller, M., Wijnen, W. J., Tan, H. L., Bezzina, C. R., Creemers, E. E., Wilde, A. A. M., Ackerman, M. J. & Pinto, Y. M., Mar 2012, In : European heart journal. 33, 6, p. 714-723 10 p.

Research output: Contribution to journalArticle

99 Scopus citations
2011

Anesthetic management of patients with Brugada syndrome: A case series and literature review

Kloesel, B., Ackerman, M. J., Sprung, J., Narr, B. J. & Weingarten, T. N., Sep 1 2011, In : Canadian Journal of Anesthesia. 58, 9, p. 824-836 13 p.

Research output: Contribution to journalReview article

38 Scopus citations

Clinical spectrum in a family with tropomyosin-mediated hypertrophic cardiomyopathy and sudden death in childhood

Makhoul, M., Ackerman, M. J., Atkins, D. L. & Law, I. H., Feb 1 2011, In : Pediatric Cardiology. 32, 2, p. 215-220 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice

Van Oort, R. J., Garbino, A., Wang, W., Dixit, S. S., Landstrom, A. P., Gaur, N., De Almeida, A. C., Skapura, D. G., Rudy, Y., Burns, A. R., Ackerman, M. J. & Wehrens, X. H. T., Mar 8 2011, In : Circulation. 123, 9, p. 979-988 10 p.

Research output: Contribution to journalArticle

151 Scopus citations

Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia- associated mutations from background genetic noise

Kapplinger, J. D., Landstrom, A. P., Salisbury, B. A., Callis, T. E., Pollevick, G. D., Tester, D. J., Cox, M. G. P. J., Bhuiyan, Z., Bikker, H., Wiesfeld, A. C. P., Hauer, R. N. W., Van Tintelen, J. P., Jongbloed, J. D. H., Calkins, H., Judge, D. P., Wilde, A. A. M. & Ackerman, M. J., Jun 7 2011, In : Journal of the American College of Cardiology. 57, 23, p. 2317-2327 11 p.

Research output: Contribution to journalArticle

201 Scopus citations

Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch

Waddell, L. B., Lemckert, F. A., Zheng, X. F., Tran, J., Evesson, F. J., Hawkes, J. M., Lek, A., Street, N. E., Lin, P., Clarke, N. F., Landstrom, A. P., Ackerman, M. J., Weisleder, N., Ma, J., North, K. N. & Cooper, S. T., Apr 1 2011, In : Journal of Neuropathology and Experimental Neurology. 70, 4, p. 302-313 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Electrocardiographic and oximetric changes during partial complex and generalized seizures

Moseley, B. D., Wirrell, E. C., Nickels, K., Johnson, J. N., Ackerman, M. J. & Britton, J., Aug 1 2011, In : Epilepsy Research. 95, 3, p. 237-245 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Electrocardiographic changes and arrhythmias following percutaneous atrial septal defect and patent foramen ovale device closure

Johnson, J. N., Marquardt, M. L., Ackerman, M. J., Asirvatham, S. J., Reeder, G. S., Cabalka, A. K., Cetta, F. & Hagler, D. J., Aug 1 2011, In : Catheterization and Cardiovascular Interventions. 78, 2, p. 254-261 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Genetic testing for potentially lethal, highly treatable inherited cardiomyopathies/channelopathies in clinical practice

Tester, D. J. & Ackerman, M. J., Mar 8 2011, In : Circulation. 123, 9, p. 1021-1037 17 p.

Research output: Contribution to journalArticle

146 Scopus citations

Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome

Barsheshet, A., Peterson, D. R., Moss, A. J., Schwartz, P. J., Kaufman, E. S., McNitt, S., Polonsky, S., Buber, J., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Towbin, J. A., Vincent, G. M., Zhang, L. & Goldenberg, I., Aug 1 2011, In : Heart rhythm. 8, 8, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

15 Scopus citations