Michael John Ackerman, MD, PhD, FACC

  • 34761 Citations
  • 103 Scopus h-Index
1991 …2020
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Research Output 1991 2019

2015
77 Citations (Scopus)
Cardiovascular Abnormalities
Arrhythmogenic Right Ventricular Dysplasia
Hypertrophic Cardiomyopathy
Myocarditis
Advisory Committees
54 Citations (Scopus)
Channelopathies
Cardiovascular Abnormalities
Brugada Syndrome
Long QT Syndrome
Advisory Committees
33 Citations (Scopus)

Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 10: The Cardiac Channelopathies: A Scientific Statement from the American Heart Association and American College of Cardiology

on behalf of the American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology & American College of Cardiology, Dec 1 2015, In : Circulation. 132, 22, p. e326-e329

Research output: Contribution to journalArticle

Channelopathies
Cardiovascular Abnormalities
Brugada Syndrome
Long QT Syndrome
Advisory Committees
50 Citations (Scopus)
Cardiovascular Abnormalities
Advisory Committees
Athletes
Cardiac Arrhythmias
46 Citations (Scopus)

Enhanced Classification of Brugada Syndrome-Associated and Long-QT Syndrome-Associated Genetic Variants in the SCN5A -Encoded Na<inf>v</inf>1.5 Cardiac Sodium Channel

Kapplinger, J. D., Giudicessi, J. R., Ye, D., Tester, D. J., Callis, T. E., Valdivia, C. R., Makielski, J. C., Wilde, A. A. & Ackerman, M. J., Aug 25 2015, In : Circulation: Cardiovascular Genetics. 8, 4, p. 582-595 14 p.

Research output: Contribution to journalArticle

Brugada Syndrome
Long QT Syndrome
Sodium Channels
Nucleotides
Computer Simulation
10 Citations (Scopus)

Enhancing the Predictive Power of Mutations in the C-Terminus of the KCNQ1-Encoded Kv7.1 Voltage-Gated Potassium Channel

Kapplinger, J. D., Tseng, A. S., Salisbury, B. A., Tester, D. J., Callis, T. E., Alders, M., Wilde, A. A. M. & Ackerman, M. J., Apr 1 2015, In : Journal of Cardiovascular Translational Research. 8, 3, p. 187-197 11 p.

Research output: Contribution to journalArticle

KCNQ1 Potassium Channel
Voltage-Gated Potassium Channels
Romano-Ward Syndrome
Long QT Syndrome
Mutation
5 Citations (Scopus)

Frequency and Cause of Transient QT Prolongation after Surgery

Joyce, D. D., Bos, J. M., Haugaa, K. H., Tarrell, R. F., Morlan, B. W., Caraballo, P. & Ackerman, M. J., Nov 15 2015, In : American Journal of Cardiology. 116, 10, p. 1605-1609 5 p.

Research output: Contribution to journalArticle

Electrolytes
Electrocardiography
Pharmaceutical Preparations
13 Citations (Scopus)

Frequency and severity of hypoglycemia in children with beta-blocker-treated long QT syndrome

Poterucha, J. T., Bos, J. M., Cannon, B. C. & Ackerman, M. J., Aug 1 2015, In : Heart Rhythm. 12, 8, p. 1815-1819 5 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Hypoglycemia
Hypoglycemic Agents
Romano-Ward Syndrome
Nadolol
74 Citations (Scopus)

Genetic purgatory and the cardiac channelopathies: Exposing the variants of uncertain/unknown significance issue

Ackerman, M. J., Nov 1 2015, In : Heart Rhythm. 12, 11, p. 2325-2331 7 p.

Research output: Contribution to journalArticle

Channelopathies
Psychological Stress
Mutation
Punishment
Genetic Testing
8 Citations (Scopus)

Genotype-Phenotype Correlations in Apical Variant Hypertrophic Cardiomyopathy

Towe, E. C., Bos, J. M., Ommen, S. R., Gersh, B. J. & Ackerman, M. J., May 1 2015, In : Congenital Heart Disease. 10, 3, p. E139-E145

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Genetic Association Studies
Genotype
Genetic Testing
Mutation
7 Citations (Scopus)

Genotype-phenotype Correlations of Hypertrophic Cardiomyopathy When Diagnosed in Children, Adolescents, and Young Adults

Loar, R. W., Bos, J. M., Will, M. L., Ommen, S. R. & Ackerman, M. J., Nov 1 2015, In : Congenital Heart Disease. 10, 6, p. 529-536 8 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Genetic Association Studies
Young Adult
Genotype
Genetic Testing
12 Citations (Scopus)

Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin i (K206I)

Warren, C. M., Karam, C. N., Wolska, B. M., Kobayashi, T., De Tombe, P. P., Arteaga, G. M., Bos, J. M., Ackerman, M. J. & Solaro, R. J., Dec 1 2015, In : Circulation: Cardiovascular Genetics. 8, 6, p. 765-773 9 p.

Research output: Contribution to journalArticle

Troponin
Catechin
Myofibrils
Hypertrophic Cardiomyopathy
Tea
37 Citations (Scopus)

Homozygous/compound heterozygous triadin mutations associated with autosomal-recessive long-QT syndrome and pediatric sudden cardiac arrest elucidation of the triadin knockout syndrome

Altmann, H. M., Tester, D. J., Will, M. L., Middha, S., Evans, J. M., Eckloff, B. W. & Ackerman, M. J., 2015, In : Circulation. 131, 23, p. 2051-2060 10 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Sudden Cardiac Death
Pediatrics
Mutation
Exome
2 Citations (Scopus)

Hypertrophic cardiomyopathy, athlete's heart, or both: A case of hypertrophic cardiomyopathy regression

Kebed, K. Y., Bos, J. M., Anavekar, N. S., Mulvagh, S. L., Ackerman, M. J. & Ommen, S. R., May 1 2015, In : Circulation: Cardiovascular Imaging. 8, 7, e003312.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Athletes
30 Citations (Scopus)

Identification and Functional Characterization of a Novel CACNA1C -Mediated Cardiac Disorder Characterized by Prolonged QT Intervals with Hypertrophic Cardiomyopathy, Congenital Heart Defects, and Sudden Cardiac Death

Boczek, N. J., Ye, D., Jin, F., Tester, D. J., Huseby, A., Bos, J. M., Johnson, A. J., Kanter, R. & Ackerman, M. J., Oct 1 2015, In : Circulation: Arrhythmia and Electrophysiology. 8, 5, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

Congenital Heart Defects
Hypertrophic Cardiomyopathy
Sudden Cardiac Death
Long QT Syndrome
Pedigree
17 Citations (Scopus)

Impact of clinical decision support preventing the use of QT-prolonging medications for patients at risk for torsade de pointes

Sorita, A., Bos, J. M., Morlan, B. W., Tarrell, R. F., Ackerman, M. J. & Caraballo, P., 2015, In : Journal of the American Medical Informatics Association. 22, e1, p. e21-e27

Research output: Contribution to journalArticle

Medical Order Entry Systems
Clinical Decision Support Systems
Torsades de Pointes
8 Citations (Scopus)

Impact of Genotype on the Occurrence of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy

Bongini, C., Ferrantini, C., Girolami, F., Coppini, R., Arretini, A., Targetti, M., Bardi, S., Castelli, G., Torricelli, F., Cecchi, F., Ackerman, M. J., Padeletti, L., Poggesi, C. & Olivotto, I., Sep 22 2015, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Atrial Fibrillation
Genotype
Genes
Genetic Testing
158 Citations (Scopus)

Incidence, cause, and comparative frequency of sudden cardiac death in national collegiate athletic association athletes a decade in review

Harmon, K. G., Asif, I. M., Maleszewski, J., Owens, D. S., Prutkin, J. M., Salerno, J. C., Zigman, M. L., Ellenbogen, R., Rao, A. L., Ackerman, M. J. & Drezner, J. A., 2015, In : Circulation. 132, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

Sudden Cardiac Death
Athletes
Sports
Incidence
Autopsy
22 Citations (Scopus)

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

Martins, A. S., Parvatiyar, M. S., Feng, H. Z., Bos, J. M., Gonzalez-Martinez, D., Vukmirovic, M., Turna, R. S., Sanchez-Gonzalez, M. A., Badger, C. D., Zorio, D. A. R., Singh, R. K., Wang, Y., Jin, J. P., Ackerman, M. J. & Pinto, J. R., Oct 1 2015, In : Circulation: Cardiovascular Genetics. 8, 5, p. 653-664 12 p.

Research output: Contribution to journalArticle

Troponin C
Hypertrophic Cardiomyopathy
Mutation
Genes
Gene Knock-In Techniques
5 Citations (Scopus)
Long QT Syndrome
Athletes
Sports
Oils
Water
8 Citations (Scopus)

MY APPROACH to treatment of the congenital long QT syndromes

Ackerman, M. J., Jan 1 2015, In : Trends in Cardiovascular Medicine. 25, 1, p. 67-69 3 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Adrenergic beta-Antagonists
Sympathectomy
Implantable Defibrillators
5 Citations (Scopus)

Neonatal ECG screening: Opinions and facts

Saul, J. P., Schwartz, P. J., Ackerman, M. J. & Triedman, J. K., Mar 1 2015, In : Heart Rhythm. 12, 3, p. 610-611 2 p.

Research output: Contribution to journalArticle

Neonatal Screening
Electrocardiography
16 Citations (Scopus)

Noninvasive potassium determination using a mathematically processed ECG: Proof of concept for a novel "blood-less, blood test"

Dillon, J. J., Desimone, C. V., Sapir, Y., Somers, V., Dugan, J. L., Bruce, C. J., Ackerman, M. J., Asirvatham, S. J., Striemer, B. L., Bukartyk, J., Scott, C. G., Bennet, K. E., Mikell, S. B., Ladewig, D. J., Gilles, E. J., Geva, A., Sadot, D. & Friedman, P. A., Jan 1 2015, In : Journal of Electrocardiology. 48, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

Gravitation
Hematologic Tests
Potassium
Electrocardiography
Feasibility Studies
37 Citations (Scopus)

Novel Timothy syndrome mutation leading to increase in CACNA1C window current

Boczek, N. J., Miller, E. M., Ye, D., Nesterenko, V. V., Tester, D. J., Antzelevitch, C., Czosek, R. J., Ackerman, M. J. & Ware, S. M., Jan 1 2015, In : Heart Rhythm. 12, 1, p. 211-219 9 p.

Research output: Contribution to journalArticle

Mutation
Exome
Action Potentials
Exons
Syndactyly
22 Citations (Scopus)

Obstructive sleep apnea in patients with congenital long QT syndrome: Implications for increased risk of sudden cardiac death

Shamsuzzaman, A. S., Somers, V., Knilans, T. K., Ackerman, M. J., Wang, Y. & Amin, R. S., Jul 1 2015, In : Sleep. 38, 7, p. 1113-1119 7 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Sudden Cardiac Death
Obstructive Sleep Apnea
Apnea
Electrocardiography
2 Citations (Scopus)

Phenotype of Children with QT Prolongation Identified Using an Institution-Wide QT Alert System

Anderson, H. N., Bos, J. M., Haugaa, K. H., Morlan, B. W., Tarrell, R. F., Caraballo, P. & Ackerman, M. J., Oct 22 2015, In : Pediatric Cardiology. 36, 7, p. 1350-1356 7 p.

Research output: Contribution to journalArticle

Pediatrics
Phenotype
Long QT Syndrome
Electrocardiography
Polypharmacy
21 Citations (Scopus)

Population-based study of QT interval prolongation in patients with rheumatoid arthritis

Chauhan, K., Ackerman, M. J., Crowson, C., Matteson, E. L. & Gabriel, S. E., 2015, In : Clinical and Experimental Rheumatology. 33, 1, p. 84-89 6 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Population
Mortality
Electrocardiography
Arthritis
38 Citations (Scopus)

Post-mortem Whole Exome Sequencing with Gene-Specific Analysis for Autopsy-Negative Sudden Unexplained Death in the Young: A Case Series

Narula, N., Tester, D. J., Paulmichl, A., Maleszewski, J. & Ackerman, M. J., 2015, In : Pediatric Cardiology. 36, 4, p. 768-778 11 p.

Research output: Contribution to journalArticle

Exome
Sudden Death
Autopsy
Genes
Channelopathies
3 Citations (Scopus)
Brugada Syndrome
Implantable Defibrillators
Sudden Cardiac Death
Syncope
Electric Stimulation
1 Citation (Scopus)

Reply to the editor - Detection of long QT syndrome in the community

Saul, J. P., Schwartz, P. J., Ackerman, M. J. & Triedman, J. K., Jul 1 2015, In : Heart Rhythm. 12, 7, p. e67-e68

Research output: Contribution to journalArticle

Attitude of Health Personnel
Neonatal Screening
Long QT Syndrome
Patient Safety
Electrocardiography
59 Citations (Scopus)

Role of common and rare variants in SCN10A: Results from the Brugada syndrome QRS locus gene discovery collaborative study

Behr, E. R., Savio-Galimberti, E., Barc, J., Holst, A. G., Petropoulou, E., Prins, B. P., Jabbari, J., Torchio, M., Berthet, M., Mizusawa, Y., Yang, T., Nannenberg, E. A., Dagradi, F., Weeke, P., Bastiaenan, R., Ackerman, M. J., Haunso, S., Leenhardt, A., Kääb, S., Probst, V. & 12 others, Redon, R., Sharma, S., Wilde, A., Tfelt-Hansen, J., Schwartz, P., Roden, D. M., Bezzina, C. R., Olesen, M., Darbar, D., Guicheney, P., Crotti, L. & Jamshidi, Y., Jun 1 2015, In : Cardiovascular Research. 106, 3, p. 520-529 10 p.

Research output: Contribution to journalArticle

Brugada Syndrome
Genetic Association Studies
Mutation
Sudden Death
Genes
7 Citations (Scopus)

Stimulant therapy in children with attention-deficit/hyperactivity disorder and concomitant long QT syndrome: A safe combination?

Rohatgi, R. K., Bos, J. M. & Ackerman, M. J., Aug 1 2015, In : Heart Rhythm. 12, 8, p. 1807-1812 6 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Attention Deficit Disorder with Hyperactivity
Therapeutics
Channelopathies
Electronic Health Records
5 Citations (Scopus)
Sudden Cardiac Death
Long QT Syndrome
Syncope
Channelopathies
Implantable Defibrillators
13 Citations (Scopus)

Sudden cardiac death in athletes

Semsarian, C., Sweeting, J. & Ackerman, M. J., Mar 18 2015, In : BMJ (Online). 350, h1218.

Research output: Contribution to journalArticle

Mass Screening
Physical Education and Training
Sudden Cardiac Death
Athletes
Cost-Benefit Analysis
6 Citations (Scopus)

Sudden cardiac death in athletes

Semsarian, C., Sweeting, J. & Ackerman, M. J., Aug 1 2015, In : British Journal of Sports Medicine. 49, 15, p. 1017-1023 7 p.

Research output: Contribution to journalArticle

Exercise-Induced Cardiomegaly
Sudden Cardiac Death
Health Promotion
Athletes
Physical Examination
12 Citations (Scopus)

Surgical Ventricular Septal Myectomy for Patients with Noonan Syndrome and Symptomatic Left Ventricular Outflow Tract Obstruction

Poterucha, J. T., Johnson, J. N., O'Leary, P. W., Connolly, H. M., Niaz, T., Maleszewski, J., Ackerman, M. J., Cetta, F., Dearani, J. A. & Eidem, B. W., Oct 1 2015, In : American Journal of Cardiology. 116, 7, p. 1116-1121 6 p.

Research output: Contribution to journalArticle

Noonan Syndrome
Ventricular Outflow Obstruction
Hypertrophic Cardiomyopathy
Left Ventricular Hypertrophy
Dilatation
1 Citation (Scopus)

Ventricular fibrillation after elective surgery in an adolescent with long QT syndrome

Kim, S. J., Pundi, K. N., Bos, J. M. & Ackerman, M. J., Nov 26 2015, In : BMJ Case Reports. 2015, A1719.

Research output: Contribution to journalArticle

Long QT Syndrome
Ventricular Fibrillation
Channelopathies
Sympathectomy
Implantable Defibrillators
9 Citations (Scopus)
Q-Type Calcium Channels
P-Type Calcium Channels
Exome
Muscle Hypotonia
Electrophysiology
2014
21 Citations (Scopus)

A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis

Hennessey, J. A., Boczek, N. J., Jiang, Y. H., Miller, J. D., Patrick, W., Pfeiffer, R., Sutphin, B. S., Tester, D. J., Barajas-Martinez, H., Ackerman, M. J., Antzelevitch, C., Kanter, R. & Pitt, G. S., 2014, In : PLoS One. 9, 9, e106982.

Research output: Contribution to journalArticle

Cardiac Arrhythmias
inactivation
Genes
arrhythmia
Long QT Syndrome
14 Citations (Scopus)

A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation

Bartos, D. C., Giudicessi, J. R., Tester, D. J., Ackerman, M. J., Ohno, S., Horie, M., Gollob, M. H., Burgess, D. E. & Delisle, B. P., Mar 2014, In : Heart Rhythm. 11, 3, p. 459-468 10 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Phosphorylation
Action Potentials
Phenotype
Mutation
7 Citations (Scopus)

Association of common variants in NOS1AP gene with sudden unexplained nocturnal death syndrome in the southern Chinese Han population

Huang, L., Yu, Y., Chen, Y., Tester, D. J., Tang, S., Ackerman, M. J., Yuan, Z. & Cheng, J., Nov 1 2014, In : International Journal of Legal Medicine. 128, 6, p. 933-938 6 p.

Research output: Contribution to journalArticle

Brugada Syndrome
Population
Genes
Haplotypes
Alleles

Atypical atrioventricular nodal reentry tachycardia in a child with polyvalvular dysplasia

Johnson, J. N., Ackerman, M. J. & Cannon, B. C., May 9 2014, In : Cardiology in the Young. 96

Research output: Contribution to journalArticle

Atrioventricular Nodal Reentry Tachycardia
Ambulatory Monitoring
Cryosurgery
Tricuspid Valve
Electrophysiology
14 Citations (Scopus)

Beta-blockers in the treatment of congenital long QT syndrome: Is one beta-blocker superior to another?

Wilde, A. A. M. & Ackerman, M. J., Sep 30 2014, In : Journal of the American College of Cardiology. 64, 13, p. 1359-1361 3 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Adrenergic beta-Antagonists
Sudden Cardiac Death
Cardiac Arrhythmias
1 Citation (Scopus)

Cardiac channelopathies and the molecular autopsy

Tester, D. J. & Ackerman, M. J., Mar 1 2014, Forensic Pathology of Infancy and Childhood. Springer New York, p. 899-942 44 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Channelopathies
Autopsy
Sudden Infant Death
Brugada Syndrome
Long QT Syndrome
60 Citations (Scopus)

Characterization of a phenotype-based genetic test prediction score for unrelated patients with hypertrophic cardiomyopathy

Bos, J. M., Will, M. L., Gersh, B. J., Kruisselbrink, T. M., Ommen, S. R. & Ackerman, M. J., 2014, In : Mayo Clinic Proceedings. 89, 6, p. 727-737 11 p.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Phenotype
Genetic Testing
Genotype
Mutation
26 Citations (Scopus)

Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome

Boczek, N. J., Ye, D., Johnson, E. K., Wang, W., Crotti, L., Tester, D. J., Dagradi, F., Mizusawa, Y., Torchio, M., Alders, M., Giudicessi, J. R., Wilde, A. A. M., Schwartz, P. J., Nerbonne, J. M. & Ackerman, M. J., Aug 1 2014, In : Circulation Research. 115, 4, p. 460-469 10 p.

Research output: Contribution to journalArticle

Semaphorin-3A
Semaphorins
Brugada Syndrome
Proteins
Voltage-Gated Potassium Channels
8 Citations (Scopus)

Compound heterozygous mutations in the SCN5A-encoded Nav1.5 cardiac sodium channel resulting in atrial standstill and His-Purkinje system disease

Baskar, S., Ackerman, M. J., Clements, D., Mayuga, K. A. & Aziz, P. F., Nov 1 2014, In : Journal of Pediatrics. 165, 5, p. 1050-1052 3 p.

Research output: Contribution to journalArticle

Sick Sinus Syndrome
Sodium Channels
Syncope
Mutation
Genes
1 Citation (Scopus)
Clinical Decision Support Systems
Electronic Health Records
Electrocardiography
Myocardial Infarction
Pediatrics
40 Citations (Scopus)

Confirmation of cause and manner of death via a comprehensive cardiac autopsy including whole exome next-generation sequencing

Loporcaro, C. G., Tester, D. J., Maleszewski, J., Kruisselbrink, T. & Ackerman, M. J., 2014, In : Archives of Pathology and Laboratory Medicine. 138, 8, p. 1083-1089 7 p.

Research output: Contribution to journalArticle

Exome
Cause of Death
Autopsy
Channelopathies
Sudden Death

Congenital long QT syndrome and concomitant early repolarization pattern: A benign association or an ICD-worthy one?

Desimone, C. V. & Ackerman, M. J., 2014, In : Heart Rhythm. 11, 9, p. 1639-1640 2 p.

Research output: Contribution to journalArticle

Romano-Ward Syndrome
Heart Conduction System
Long QT Syndrome
Electrocardiography
Heart Rate