Michael John Ackerman, MD, PhD, FACC

  • 37409 Citations
  • 106 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2016

Spectrum and prevalence of CALM1-, CALM2-, and CALM3-encoded calmodulin variants in long QT syndrome and functional characterization of a novel long QT syndrome-associated calmodulin missense variant, E141G

Boczek, N. J., Gomez-Hurtado, N., Ye, D., Calvert, M. L., Tester, D. J., Kryshtal, D. O., Hwang, H. S., Johnson, C. N., Chazin, W. J., Loporcaro, C. G., Shah, M., Papez, A. L., Lau, Y. R., Kanter, R., Knollmann, B. C. & Ackerman, M. J., Apr 1 2016, In : Circulation: Cardiovascular Genetics. 9, 2, p. 136-146 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Sudden cardiac death in the young

Ackerman, M., Atkins, D. L. & Triedman, J. K., Mar 8 2016, In : Circulation. 133, 10, p. 1006-1026 21 p.

Research output: Contribution to journalReview article

40 Scopus citations

The effect of mitral valve surgery on ventricular arrhythmia in patients with bileaflet mitral valve prolapse

Naksuk, N., Syed, F. F., Krittanawong, C., Anderson, M. J., Ebrille, E., DeSimone, C. V., Vaidya, V. R., Ponamgi, S. P., Suri, R. M., Ackerman, M. J., Nkomo, V. T., Asirvatham, S. J. & Noseworthy, P., Nov 1 2016, In : Indian Pacing and Electrophysiology Journal. 16, 6, p. 187-191 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

The Natural History of Nonobstructive Hypertrophic Cardiomyopathy

Hebl, V. B., Miranda, W. R., Ong, K. C., Hodge, D. O., Bos, J. M., Gentile, F., Klarich, K. W., Nishimura, R. A., Ackerman, M. J., Gersh, B. J., Ommen, S. R. & Geske, J. B., Mar 1 2016, In : Mayo Clinic Proceedings. 91, 3, p. 279-287 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

The Promise and Peril of Precision Medicine: Phenotyping Still Matters Most

Ackerman, J. P., Bartos, D. C., Kapplinger, J. D., Tester, D. J., Delisle, B. P. & Ackerman, M. J., Nov 1 2016, In : Mayo Clinic proceedings. 91, 11, p. 1606-1616 11 p.

Research output: Contribution to journalReview article

53 Scopus citations

Treating obstructive hypertrophic cardiomyopathy—what's best, what's next?

Dearani, J. A. & Ackerman, M. J., Oct 1 2016, In : Journal of Thoracic and Cardiovascular Surgery. 152, 4, p. 988-990 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Ventricular premature contraction associated with mitral valve prolapse

Hong-TaoYuan, Yang, M., Zhong, L., Lee, Y. H., Vaidya, V. R., Asirvatham, S. J., Ackerman, M. J., Pislaru, S. V., Suri, R. M., Slusser, J. P., Hodge, D. O., Wang, Y. T. & Cha, Y-M., Oct 15 2016, In : International Journal of Cardiology. 221, p. 1144-1149 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Whole-exome molecular autopsy after exertion-related sudden unexplained death in the young

Anderson, J. H., Tester, D. J., Will, M. L. & Ackerman, M. J., Jun 1 2016, In : Circulation: Cardiovascular Genetics. 9, 3, p. 259-265 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Whole Exome Sequencing, Familial Genomic Triangulation, and Systems Biology Converge to Identify a Novel Nonsense Mutation in TAB2-encoded TGF-beta Activated Kinase 1 in a Child with Polyvalvular Syndrome

Ackerman, J. P., Smestad, J. A., Tester, D. J., Qureshi, M. Y., Crabb, B. A., Mendelsohn, N. J. & Ackerman, M. J., Sep 1 2016, In : Congenital Heart Disease. 11, 5, p. 452-461 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Arrhythmogenic biophysical phenotype for SCN5A mutation S1787N depends upon splice variant background and intracellular acidosis

Hu, R. M., Tan, B. H., Tester, D. J., Song, C., He, Y., Dovat, S., Peterson, B. Z., Ackerman, M. J. & Makielski, J. C., Apr 29 2015, In : PloS one. 10, 4, e0124921.

Research output: Contribution to journalArticle

11 Scopus citations

Athletes with Implantable Cardioverter Defibrillators

Ponamgi, S. P., DeSimone, C. V. & Ackerman, M. J., Jul 1 2015, In : Clinics in Sports Medicine. 34, 3, p. 473-487 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Automated external defibrillator rescues among children with diagnosed and treated long QT syndrome

Pundi, K. N., Bos, J. M., Cannon, B. C. & Ackerman, M. J., Apr 1 2015, In : Heart rhythm. 12, 4, p. 776-781 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Breath Holding Spells in Children with Long QT Syndrome

Robinson, J. A., Bos, J. M., Etheridge, S. P. & Ackerman, M. J., Jul 1 2015, In : Congenital Heart Disease. 10, 4, p. 354-361 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

CALM3 mutation associated with long QT syndrome

Reed, G. J., Boczek, N. J., Etheridge, S. P. & Ackerman, M. J., Feb 1 2015, In : Heart rhythm. 12, 2, p. 419-422 4 p.

Research output: Contribution to journalArticle

54 Scopus citations

Clinical management of catecholaminergic polymorphic ventricular tachycardia the role of left cardiac sympathetic denervation

De Ferrari, G. M., Dusi, V., Spazzolini, C., Bos, J. M., Abrams, D. J., Berul, C. I., Crotti, L., Davis, A. M., Eldar, M., Kharlap, M., Khoury, A., Krahn, A. D., Leenhardt, A., Moir, C. R., Odero, A., Nordkamp, L. O., Paul, T., Rosés I Noguer, F., Shkolnikova, M., Till, J. & 3 others, Wilde, A. A. M., Ackerman, M. J. & Schwartz, P. J., 2015, In : Circulation. 131, 25, p. 2185-2193 9 p.

Research output: Contribution to journalArticle

126 Scopus citations

Effects on repolarization using dynamic QT interval monitoring in long-QT patients following left cardiac sympathetic denervation

Desimone, C. V., Bos, J. M., Bos, K. M., Liang, J. J., Patel, N. A., Hodge, D. O., Noheria, A., Asirvatham, S. J. & Ackerman, M. J., Apr 1 2015, In : Journal of Cardiovascular Electrophysiology. 26, 4, p. 434-439 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Electrocardiographic Predictors of Torsadogenic Risk During Dofetilide or Sotalol Initiation: Utility of a Novel T Wave Analysis Program

Sugrue, A., Kremen, V., Qiang, B., Sheldon, S. H., DeSimone, C. V., Sapir, Y., Striemer, B. L., Brady, P., Asirvatham, S. J., Ackerman, M. J., Friedman, P. A. & Noseworthy, P., Sep 28 2015, In : Cardiovascular Drugs and Therapy. 29, 5, p. 433-441 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Electromechanical window negativity in genotyped long-QT syndrome patients: Relation to arrhythmia risk

Ter Bekke, R. M. A., Haugaa, K. H., Van Den Wijngaard, A., Bos, J. M., Ackerman, M. J., Edvardsen, T. & Volders, P. G. A., Jan 14 2015, In : European heart journal. 36, 3, p. 179-186 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 4: Congenital Heart Disease: A Scientific Statement from the American Heart Association and American College of Cardiology

Van Hare, G. F., Ackerman, M. J., Evangelista, J. A. K., Kovacs, R. J., Myerburg, R. J., Shafer, K. M., Warnes, C. A. & Washington, R. L., 2015, In : Journal of the American College of Cardiology. 66, 21, p. 2372-2384 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 10: The Cardiac Channelopathies: A Scientific Statement from the American Heart Association and American College of Cardiology

on behalf of the American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology & American College of Cardiology, Dec 1 2015, In : Circulation. 132, 22, p. e326-e329

Research output: Contribution to journalArticle

36 Scopus citations

Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 4: Congenital Heart Disease: A Scientific Statement from the American Heart Association and American College of Cardiology

on behalf of the American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology & American College of Cardiology, Dec 1 2015, In : Circulation. 132, 22, p. e281-e291

Research output: Contribution to journalArticle

56 Scopus citations

Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 3: Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy and Other Cardiomyopathies, and Myocarditis: A Scientific Statement from the American Heart Association and American College of Cardiology

on behalf of the American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology & American College of Cardiology, Dec 1 2015, In : Circulation. 132, 22, p. e273-e280

Research output: Contribution to journalArticle

96 Scopus citations

Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Task Force 9: Arrhythmias and Conduction Defects: A Scientific Statement from the American Heart Association and American College of Cardiology

on behalf of the American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology & American College of Cardiology, Dec 1 2015, In : Circulation. 132, 22, p. e315-e325

Research output: Contribution to journalArticle

50 Scopus citations

Enhanced Classification of Brugada Syndrome-Associated and Long-QT Syndrome-Associated Genetic Variants in the SCN5A -Encoded Nav1.5 Cardiac Sodium Channel

Kapplinger, J. D., Giudicessi, J. R., Ye, D., Tester, D. J., Callis, T. E., Valdivia, C. R., Makielski, J. C., Wilde, A. A. & Ackerman, M. J., Aug 25 2015, In : Circulation: Cardiovascular Genetics. 8, 4, p. 582-595 14 p.

Research output: Contribution to journalArticle

52 Scopus citations

Enhancing the Predictive Power of Mutations in the C-Terminus of the KCNQ1-Encoded Kv7.1 Voltage-Gated Potassium Channel

Kapplinger, J. D., Tseng, A. S., Salisbury, B. A., Tester, D. J., Callis, T. E., Alders, M., Wilde, A. A. M. & Ackerman, M. J., Apr 1 2015, In : Journal of cardiovascular translational research. 8, 3, p. 187-197 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Frequency and Cause of Transient QT Prolongation after Surgery

Joyce, D. D., Bos, J. M., Haugaa, K. H., Tarrell, R. F., Morlan, B. W., Caraballo, P. & Ackerman, M. J., Nov 15 2015, In : American Journal of Cardiology. 116, 10, p. 1605-1609 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Frequency and severity of hypoglycemia in children with beta-blocker-treated long QT syndrome

Poterucha, J. T., Bos, J. M., Cannon, B. C. & Ackerman, M. J., Aug 1 2015, In : Heart Rhythm. 12, 8, p. 1815-1819 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Genetic purgatory and the cardiac channelopathies: Exposing the variants of uncertain/unknown significance issue

Ackerman, M. J., Nov 1 2015, In : Heart Rhythm. 12, 11, p. 2325-2331 7 p.

Research output: Contribution to journalArticle

88 Scopus citations

Genotype-Phenotype Correlations in Apical Variant Hypertrophic Cardiomyopathy

Towe, E. C., Bos, J. M., Ommen, S. R., Gersh, B. J. & Ackerman, M. J., May 1 2015, In : Congenital Heart Disease. 10, 3, p. E139-E145

Research output: Contribution to journalArticle

10 Scopus citations

Genotype-phenotype Correlations of Hypertrophic Cardiomyopathy When Diagnosed in Children, Adolescents, and Young Adults

Loar, R. W., Bos, J. M., Will, M. L., Ommen, S. R. & Ackerman, M. J., Nov 1 2015, In : Congenital Heart Disease. 10, 6, p. 529-536 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin i (K206I)

Warren, C. M., Karam, C. N., Wolska, B. M., Kobayashi, T., De Tombe, P. P., Arteaga, G. M., Bos, J. M., Ackerman, M. J. & Solaro, R. J., Dec 1 2015, In : Circulation: Cardiovascular Genetics. 8, 6, p. 765-773 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Homozygous/compound heterozygous triadin mutations associated with autosomal-recessive long-QT syndrome and pediatric sudden cardiac arrest elucidation of the triadin knockout syndrome

Altmann, H. M., Tester, D. J., Will, M. L., Middha, S., Evans, J. M., Eckloff, B. W. & Ackerman, M. J., 2015, In : Circulation. 131, 23, p. 2051-2060 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Hypertrophic cardiomyopathy, athlete's heart, or both: A case of hypertrophic cardiomyopathy regression

Kebed, K. Y., Bos, J. M., Anavekar, N. S., Mulvagh, S. L., Ackerman, M. J. & Ommen, S. R., May 1 2015, In : Circulation: Cardiovascular Imaging. 8, 7, e003312.

Research output: Contribution to journalComment/debate

2 Scopus citations

Identification and Functional Characterization of a Novel CACNA1C -Mediated Cardiac Disorder Characterized by Prolonged QT Intervals with Hypertrophic Cardiomyopathy, Congenital Heart Defects, and Sudden Cardiac Death

Boczek, N. J., Ye, D., Jin, F., Tester, D. J., Huseby, A., Bos, J. M., Johnson, A. J., Kanter, R. & Ackerman, M. J., Oct 1 2015, In : Circulation: Arrhythmia and Electrophysiology. 8, 5, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Impact of clinical decision support preventing the use of QT-prolonging medications for patients at risk for torsade de pointes

Sorita, A., Bos, J. M., Morlan, B. W., Tarrell, R. F., Ackerman, M. J. & Caraballo, P., 2015, In : Journal of the American Medical Informatics Association. 22, e1, p. e21-e27

Research output: Contribution to journalArticle

17 Scopus citations

Impact of Genotype on the Occurrence of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy

Bongini, C., Ferrantini, C., Girolami, F., Coppini, R., Arretini, A., Targetti, M., Bardi, S., Castelli, G., Torricelli, F., Cecchi, F., Ackerman, M. J., Padeletti, L., Poggesi, C. & Olivotto, I., Sep 22 2015, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

8 Scopus citations

Incidence, cause, and comparative frequency of sudden cardiac death in national collegiate athletic association athletes a decade in review

Harmon, K. G., Asif, I. M., Maleszewski, J. J., Owens, D. S., Prutkin, J. M., Salerno, J. C., Zigman, M. L., Ellenbogen, R., Rao, A. L., Ackerman, M. J. & Drezner, J. A., Jan 1 2015, In : Circulation. 132, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

195 Scopus citations

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

Martins, A. S., Parvatiyar, M. S., Feng, H. Z., Bos, J. M., Gonzalez-Martinez, D., Vukmirovic, M., Turna, R. S., Sanchez-Gonzalez, M. A., Badger, C. D., Zorio, D. A. R., Singh, R. K., Wang, Y., Jin, J. P., Ackerman, M. J. & Pinto, J. R., Oct 1 2015, In : Circulation: Cardiovascular Genetics. 8, 5, p. 653-664 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
6 Scopus citations

MY APPROACH to treatment of the congenital long QT syndromes

Ackerman, M. J., Jan 1 2015, In : Trends in cardiovascular medicine. 25, 1, p. 67-69 3 p.

Research output: Contribution to journalComment/debate

8 Scopus citations

Neonatal ECG screening: Opinions and facts

Saul, J. P., Schwartz, P. J., Ackerman, M. J. & Triedman, J. K., Mar 1 2015, In : Heart rhythm. 12, 3, p. 610-611 2 p.

Research output: Contribution to journalEditorial

5 Scopus citations

Noninvasive potassium determination using a mathematically processed ECG: Proof of concept for a novel "blood-less, blood test"

Dillon, J. J., Desimone, C. V., Sapir, Y., Somers, V. K., Dugan, J. L., Bruce, C. J., Ackerman, M. J., Asirvatham, S. J., Striemer, B. L., Bukartyk, J., Scott, C. G., Bennet, K. E., Mikell, S. B., Ladewig, D. J., Gilles, E. J., Geva, A., Sadot, D. & Friedman, P. A., Jan 1 2015, In : Journal of Electrocardiology. 48, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Novel Timothy syndrome mutation leading to increase in CACNA1C window current

Boczek, N. J., Miller, E. M., Ye, D., Nesterenko, V. V., Tester, D. J., Antzelevitch, C., Czosek, R. J., Ackerman, M. J. & Ware, S. M., Jan 1 2015, In : Heart rhythm. 12, 1, p. 211-219 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Obstructive sleep apnea in patients with congenital long QT syndrome: Implications for increased risk of sudden cardiac death

Shamsuzzaman, A. S., Somers, V., Knilans, T. K., Ackerman, M. J., Wang, Y. & Amin, R. S., Jul 1 2015, In : Sleep. 38, 7, p. 1113-1119 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Phenotype of Children with QT Prolongation Identified Using an Institution-Wide QT Alert System

Anderson, H. N., Bos, J. M., Haugaa, K. H., Morlan, B. W., Tarrell, R. F., Caraballo, P. & Ackerman, M. J., Oct 22 2015, In : Pediatric Cardiology. 36, 7, p. 1350-1356 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Population-based study of QT interval prolongation in patients with rheumatoid arthritis

Chauhan, K., Ackerman, M. J., Crowson, C., Matteson, E. L. & Gabriel, S. E., 2015, In : Clinical and Experimental Rheumatology. 33, 1, p. 84-89 6 p.

Research output: Contribution to journalArticle

25 Scopus citations