• 20568 Citations
  • 82 Scopus h-Index
1976 …2019

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2019

Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice

Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., Evans, C. H., Gambotto, A., Niedernhofer, L. J. & Robbins, P. D., Aug 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 8, p. 9505-9515 11 p.

Research output: Contribution to journalArticle

An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis in Vitro and in Vivo

Zhang, W., De La Vega, R. E., Coenen, M. J., Müller, S. A., Peniche Silva, C. J., Aneja, M. K., Plank, C., Van Griensven, M., Evans, C. H. & Balmayor, E. R., Jan 1 2019, In : Tissue Engineering - Part A. 25, 1-2, p. 131-144 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Paracrine effects of living human bone particles on the osteogenic differentiation of mesenchymal stem cells

Atasoy-Zeybek, A., Ivkovic, A., Beyzadeoglu, T., Onal, A., Evans, C. H. & Kose, G. T., Dec 2019, In : European Cells and Materials. 38, p. 14-22 9 p.

Research output: Contribution to journalArticle

Open Access

Regenerative rehabilitation: The role of mechanotransduction in orthopaedic regenerative medicine

Glatt, V., Evans, C. H. & Stoddart, M. J., Jan 1 2019, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

2 Scopus citations

Response of the Injured Tendon to Growth Factors in the Presence or Absence of the Paratenon

Müller, S. A., Quirk, N. P., Müller-Lebschi, J. A., Heisterbach, P. E., Dürselen, L., Majewski, M. & Evans, C. H., Feb 1 2019, In : American Journal of Sports Medicine. 47, 2, p. 462-467 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Specific, sensitive, and stable reporting of human mesenchymal stromal cell chondrogenesis

De La Vega, R. E., Scheu, M., Brown, L. A., Evans, C. H., Ferreira, E. & Porter, R. M., Mar 1 2019, In : Tissue Engineering - Part C: Methods. 25, 3, p. 176-190 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Arthritis Gene Therapy Approved in Korea

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 15 2018, In : Journal of the American Academy of Orthopaedic Surgeons. 26, 2, p. e36-e38

Research output: Contribution to journalArticle

6 Scopus citations

Arthritis gene therapy is becoming a reality

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., May 9 2018, (Accepted/In press) In : Nature Reviews Rheumatology. p. 1-2 2 p.

Research output: Contribution to journalArticle

7 Scopus citations

Catering to chondrocytes

Evans, C. H., Nov 28 2018, In : Science Translational Medicine. 10, 469, eaav7043.

Research output: Contribution to journalArticle

2 Scopus citations

Effects of freeze-thaw on the biomechanical and structural properties of the rat Achilles tendon

Quirk, N. P., Lopez De Padilla, C., De La Vega, R. E., Coenen, M. J., Tovar, A., Evans, C. H. & Müller, S. A., Nov 16 2018, In : Journal of Biomechanics. 81, p. 52-57 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Gene therapy for osteoarthritis: Pharmacokinetics of intra-articular self-complementary adeno-associated virus interleukin-1 receptor antagonist delivery in an equine model

Watson Levings, R. S., Broome, T. A., Smith, A. D., Rice, B. L., Gibbs, E. P., Myara, D. A., Hyddmark, E. V., Nasri, E., Zarezadeh, A., Levings, P. P., Lu, Y., White, M. E., Dacanay, E. A., Foremny, G. B., Evans, C. H., Morton, A. J., Winter, M., Dark, M. J., Nickerson, D. M., Colahan, P. T. & 1 others, Ghivizzani, S. C., Jun 1 2018, In : Human Gene Therapy Clinical Development. 29, 2, p. 90-100 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Image Analysis Software as a Strategy to Improve the Radiographic Determination of Fracture Healing

Duryea, J., Evans, C. H. & Glatt, V., Sep 1 2018, In : Journal of orthopaedic trauma. 32, 9, p. e354-e358

Research output: Contribution to journalArticle

Improved tendon healing using bFGF, BMP-12 and TGFβ1 in a rat model

Majewski, M., Heisterbach, P., Jaquiéry, C., Dürselen, L., Todorov, A., Martin, I., Evans, C. H. & Müller, S. A., Jan 1 2018, In : European Cells and Materials. 35, p. 318-334 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Self-complementary adeno-associated virus-mediated interleukin-1 receptor antagonist gene delivery for the treatment of osteoarthritis: Test of efficacy in an equine model

Watson Levings, R. S., Smith, A. D., Broome, T. A., Rice, B. L., Gibbs, E. P., Myara, D. A., Hyddmark, E. V., Nasri, E., Zarezadeh, A., Levings, P. P., Lu, Y., White, M. E., Dacanay, E. A., Foremny, G. B., Evans, C. H., Morton, A. J., Winter, M., Dark, M. J., Nickerson, D. M., Colahan, P. T. & 1 others, Ghivizzani, S. C., Jun 1 2018, In : Human Gene Therapy Clinical Development. 29, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

State of art and limitations in genetic engineering to induce stable chondrogenic phenotype

Graceffa, V., Vinatier, C., Guicheux, J., Evans, C. H., Stoddart, M., Alini, M. & Zeugolis, D. I., Jan 1 2018, (Accepted/In press) In : Biotechnology Advances.

Research output: Contribution to journalArticle

3 Scopus citations

The Role of the Paratenon in Achilles Tendon Healing: A Study in Rats

Müller, S. A., Evans, C. H., Heisterbach, P. E. & Majewski, M., Apr 1 2018, In : American Journal of Sports Medicine. 46, 5, p. 1214-1219 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Contribution of Implanted, Genetically Modified Muscle Progenitor Cells Expressing BMP-2 to New Bone Formation in a Rat Osseous Defect

De La Vega, R. E., De Padilla, C. L., Trujillo, M., Quirk, N., Porter, R. M., Evans, C. H. & Ferreira, E., 2017, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

5 Scopus citations

Extended release of proteins following encapsulation in hydroxyapatite/chitosan composite scaffolds for bone tissue engineering applications

Devine, D. M., Hoctor, E., Hayes, J. S., Sheehan, E. & Evans, C. H., Jan 1 2017, (Accepted/In press) In : Materials Science and Engineering C.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Drug delivery to chondrocytes

Evans, C. H., Jan 1 2016, In : Osteoarthritis and Cartilage. 24, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effect of a Simple Collagen Type i Sponge for Achilles Tendon Repair in a Rat Model

Müller, S. A., Dürselen, L., Heisterbach, P., Evans, C. H. & Majewski, M., Aug 1 2016, In : American Journal of Sports Medicine. 44, 8, p. 1998-2004 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Improving translation success of cell-based therapies in orthopaedics

Bara, J. J., Herrmann, M., Evans, C. H., Miclau, T., Ratcliffe, A. & Richards, R. G., Jan 1 2016, In : Journal of Orthopaedic Research. 34, 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Interaction between living bone particles and rhBMP-2 in large segmental defect healing in the rat femur

Liu, F., Wells, J. W., Porter, R. M., Glatt, V., Shen, Z., Schinhan, M., Ivkovic, A., Vrahas, M. S., Evans, C. H. & Ferreira, E., 2016, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

7 Scopus citations

Reverse dynamization influence of fixator stiffness on the mode and efficiency of large-bone-defect healing at different doses of rhBMP-2

Glatt, V., Bartnikowski, N., Quirk, N., Schuetz, M. & Evans, C. H., Apr 20 2016, In : Journal of Bone and Joint Surgery - American Volume. 98, 8, p. 677-687 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Safety and biodistribution assessment of sc-rAAV2.5IL-1Ra administered via intra-articular injection in a mono-iodoacetate-induced osteoarthritis rat model

Wang, G., Evans, C. H., Benson, J. M., Hutt, J. A., Seagrave, J. C., Wilder, J. A., Grieger, J. C., Samulski, R. J. & Terse, P. S., Mar 16 2016, In : Molecular Therapy - Methods and Clinical Development. 3, p. 15052 1 p.

Research output: Contribution to journalArticle

13 Scopus citations

Tissue engineering and regenerative approaches to improving the healing of large bone defects

Verrier, S., Alini, M., Alsberg, E., Buchman, S. R., Kelly, D., Laschke, M. W., Menger, M. D., Murphy, W. L., Stegemann, J. P., Schütz, M., Miclau, T., Stoddart, M. J. & Evans, C. H., Jul 1 2016, In : European Cells and Materials. 32, p. 87-110 24 p.

Research output: Contribution to journalArticle

36 Scopus citations

Why does bone have TERM limits?

Evans, C. H. & Stoddart, M. J., Jun 1 2016, In : Injury. 47, 6, p. 1159-1161 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Biologics for tendon repair

Docheva, D., Müller, S. A., Majewski, M. & Evans, C. H., Apr 1 2015, In : Advanced Drug Delivery Reviews. 84, p. 222-239 18 p.

Research output: Contribution to journalArticle

193 Scopus citations

Gene therapy approaches to regenerating the musculoskeletal system

Evans, C. H. & Huard, J., Apr 1 2015, In : Nature Reviews Rheumatology. 11, 4, p. 234-242 9 p.

Research output: Contribution to journalArticle

103 Scopus citations

Native, Living Tissues as Cell Seeded Scaffolds

Evans, C. H., Mar 1 2015, In : Annals of Biomedical Engineering. 43, 3, p. 787-795 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle

Liu, F., Ferreira, E., Porter, R. M., Glatt, V., Schinhan, M., Shen, Z., Randolph, M. A., Kirker-Head, C. A., Wehling, C., Vrahas, M. S., Evans, C. H. & Wells, J. W., 2015, In : European Cells and Materials. 30, p. 118-131 14 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols

Madry, H., Alini, M., Stoddart, M. J., Evans, C. H., Miclau, T. & Steiner, S., May 6 2014, In : European Cells and Materials. 27, SUPPL, p. 17-21 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

On the shoulders of giants: The future of the Journal of Orthopaedic Research

Alman, B. & Evans, C. H., 2014, In : Journal of Orthopaedic Research. 32, 9, p. 1095-1096 2 p.

Research output: Contribution to journalArticle

Preclinical toxicity evaluation of AAV for pain: Evidence from human AAV studies and from the pharmacology of analgesic drugs

Pleticha, J., Heilmann, L. F., Evans, C. H., Asokan, A., Samulski, R. J. & Beutler, A. S., 2014, In : Molecular Pain. 10, 1, Article 54.

Research output: Contribution to journalArticle

11 Scopus citations

Progress in intra-articular therapy

Evans, C. H., Kraus, V. B. & Setton, L. A., Jan 2014, In : Nature Reviews Rheumatology. 10, 1, p. 11-22 12 p.

Research output: Contribution to journalArticle

148 Scopus citations

TNFα and IL-1β influence the differentiation and migration of murine MSCs independently of the NF-κB pathway

Sullivan, C. B., Porter, R. M., Evans, C. H., Ritter, T., Shaw, G., Barry, F. & Murphy, J. M., Aug 27 2014, In : Stem Cell Research and Therapy. 5, 4, 104.

Research output: Contribution to journalArticle

28 Scopus citations

Using genes to facilitate the endogenous repair and regeneration of orthopaedic tissues

Evans, C. H., 2014, In : International Orthopaedics. 38, 9, p. 1761-1769 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2013

Advances in regenerative orthopedics

Evans, C. H., 2013, In : Mayo Clinic Proceedings. 88, 11, p. 1323-1329 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints

Vo, N., Niedernhofer, L. J., Nasto, L. A., Jacobs, L., Robbins, P. D., Kang, J. & Evans, C. H., Jun 2013, In : Journal of Orthopaedic Research. 31, 6, p. 831-837 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Arginase Treatment Prevents the Recovery of Canine Lymphoma and Osteosarcoma Cells Resistant to the Toxic Effects of Prolonged Arginine Deprivation

Wells, J. W., Evans, C. H., Scott, M. C., Rütgen, B. C., O'Brien, T. D., Modiano, J. F., Cvetkovic, G. & Tepic, S., Jan 30 2013, In : PLoS One. 8, 1, e54464.

Research output: Contribution to journalArticle

4 Scopus citations

Arthritis gene therapy and its tortuous path into the clinic

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Apr 2013, In : Translational Research. 161, 4, p. 205-216 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds

Florine, E. M., Miller, R. E., Porter, R. M., Evans, C. H., Kurz, B. & Grodzinsky, A. J., Jan 2013, In : Cartilage. 4, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow

Ferreira, E., Porter, R. M., Wehling, N., O'Sullivan, R. P., Liu, F., Boskey, A., Estok, D. M., Harris, M. B., Vrahas, M. S., Evans, C. H. & Wells, J. W., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29494-29505 12 p.

Research output: Contribution to journalArticle

42 Scopus citations
2012

Design, characterisation and in vivo testing of a new, adjustable stiffness, external fixator for the rat femur

Glatt, V., Evans, C. H. & Matthys, R., Jan 2012, In : European Cells and Materials. 23, p. 289-299 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of BMP-12, TGF-β1 and autologous conditioned serum on growth factor expression in Achilles tendon healing

Heisterbach, P. E., Todorov, A., Flückiger, R., Evans, C. H. & Majewski, M., 2012, In : Knee Surgery, Sports Traumatology, Arthroscopy. 20, 10, p. 1907-1914 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair

Liu, F., Porter, R. M., Wells, J., Glatt, V., Pilapil, C. & Evans, C. H., Jul 2012, In : Journal of Orthopaedic Research. 30, 7, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors

Evans, C. H., Liu, F., Porter, R. M., O'Sullivan, R. P., Merghoub, T., Lunsford, E. P., Robichaud, K., Van Valen, F., Lessnick, S. L., Gebhardt, M. C. & Wells, J. W., Oct 1 2012, In : Clinical Cancer Research. 18, 19, p. 5341-5351 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Gene delivery to bone

Evans, C. H., Sep 2012, In : Advanced Drug Delivery Reviews. 64, 12, p. 1331-1340 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

Genetic mismatch affects the immunosuppressive properties of mesenchymal stem cells in vitro and their ability to influence the course of collagen-induced arthritis

Sullivan, C., Murphy, J. M., Griffin, M. D., Porter, R. M., Evans, C. H., O'Flatharta, C., Shaw, G. & Barry, F., Jul 19 2012, In : Arthritis Research and Therapy. 14, 4, R167.

Research output: Contribution to journalArticle

28 Scopus citations

Improved healing of large segmental defects in the rat femur by reverse dynamization in the presence of bone morphogenetic protein-2

Glatt, V., Miller, M., Ivkovic, A., Liu, F., Parry, N., Griffin, D., Vrahas, M. & Evans, C. H., Nov 21 2012, In : Journal of Bone and Joint Surgery - Series A. 94, 22, p. 2063-2073 11 p.

Research output: Contribution to journalArticle

31 Scopus citations