• 20302 Citations
  • 81 Scopus h-Index
1976 …2019
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Research Output 1976 2019

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Article
2019

Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice

Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., Evans, C. H., Gambotto, A., Niedernhofer, L. J. & Robbins, P. D., Aug 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 8, p. 9505-9515 11 p.

Research output: Contribution to journalArticle

Gene transfer
Interleukin-23
Inbred NOD Mouse
Psoriatic Arthritis
Genes
4 Citations (Scopus)

An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis in Vitro and in Vivo

Zhang, W., De La Vega, R. E., Coenen, M. J., Müller, S. A., Peniche Silva, C. J., Aneja, M. K., Plank, C., Van Griensven, M., Evans, C. H. & Balmayor, E. R., Jan 1 2019, In : Tissue Engineering - Part A. 25, 1-2, p. 131-144 14 p.

Research output: Contribution to journalArticle

Untranslated Regions
RNA
Osteogenesis
Messenger RNA
Stem cells

Paracrine effects of living human bone particles on the osteogenic differentiation of mesenchymal stem cells

Atasoy-Zeybek, A., Ivkovic, A., Beyzadeoglu, T., Onal, A., Evans, C. H. & Kose, G. T., Dec 2019, In : European Cells and Materials. 38, p. 14-22 9 p.

Research output: Contribution to journalArticle

Open Access
Stem cells
Mesenchymal Stromal Cells
Bone
Bone and Bones
Autografts
2 Citations (Scopus)

Regenerative rehabilitation: The role of mechanotransduction in orthopaedic regenerative medicine

Glatt, V., Evans, C. H. & Stoddart, M. J., Jan 1 2019, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

Regenerative Medicine
Orthopedics
Rehabilitation
Medicine
Bone and Bones

Response of the Injured Tendon to Growth Factors in the Presence or Absence of the Paratenon

Müller, S. A., Quirk, N. P., Müller-Lebschi, J. A., Heisterbach, P. E., Dürselen, L., Majewski, M. & Evans, C. H., Feb 1 2019, In : American Journal of Sports Medicine. 47, 2, p. 462-467 6 p.

Research output: Contribution to journalArticle

Achilles Tendon
Tendons
Intercellular Signaling Peptides and Proteins
Platelet-Rich Plasma
Histology

Specific, sensitive, and stable reporting of human mesenchymal stromal cell chondrogenesis

De La Vega, R. E., Scheu, M., Brown, L. A., Evans, C. H., Ferreira, E. & Porter, R. M., Mar 1 2019, In : Tissue Engineering - Part C: Methods. 25, 3, p. 176-190 15 p.

Research output: Contribution to journalArticle

Chondrogenesis
Stem cells
Mesenchymal Stromal Cells
Cartilage
Cell culture
2018
5 Citations (Scopus)

Arthritis Gene Therapy Approved in Korea

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 15 2018, In : Journal of the American Academy of Orthopaedic Surgeons. 26, 2, p. e36-e38

Research output: Contribution to journalArticle

Korea
Genetic Therapy
Arthritis
Cartilage
6 Citations (Scopus)

Arthritis gene therapy is becoming a reality

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., May 9 2018, (Accepted/In press) In : Nature Reviews Rheumatology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Genetic Therapy
Arthritis
Republic of Korea
Osteoarthritis
Genes
2 Citations (Scopus)

Catering to chondrocytes

Evans, C. H., Nov 28 2018, In : Science Translational Medicine. 10, 469, eaav7043.

Research output: Contribution to journalArticle

Chondrocytes
Cartilage
Osteoarthritis
Technology
2 Citations (Scopus)

Effects of freeze-thaw on the biomechanical and structural properties of the rat Achilles tendon

Quirk, N. P., Lopez De Padilla, C., De La Vega, R. E., Coenen, M. J., Tovar, A., Evans, C. H. & Müller, S. A., Nov 16 2018, In : Journal of Biomechanics. 81, p. 52-57 6 p.

Research output: Contribution to journalArticle

Achilles Tendon
Tendons
Rats
Structural properties
Freezing
5 Citations (Scopus)

Gene therapy for osteoarthritis: Pharmacokinetics of intra-articular self-complementary adeno-associated virus interleukin-1 receptor antagonist delivery in an equine model

Watson Levings, R. S., Broome, T. A., Smith, A. D., Rice, B. L., Gibbs, E. P., Myara, D. A., Hyddmark, E. V., Nasri, E., Zarezadeh, A., Levings, P. P., Lu, Y., White, M. E., Dacanay, E. A., Foremny, G. B., Evans, C. H., Morton, A. J., Winter, M., Dark, M. J., Nickerson, D. M., Colahan, P. T. & 1 others, Ghivizzani, S. C., Jun 1 2018, In : Human Gene Therapy Clinical Development. 29, 2, p. 90-100 11 p.

Research output: Contribution to journalArticle

Dependovirus
Interleukin-1 Receptors
Osteoarthritis
Genetic Therapy
Horses

Image Analysis Software as a Strategy to Improve the Radiographic Determination of Fracture Healing

Duryea, J., Evans, C. H. & Glatt, V., Sep 1 2018, In : Journal of orthopaedic trauma. 32, 9, p. e354-e358

Research output: Contribution to journalArticle

Fracture Healing
Software
Tomography
X-Rays
Bone and Bones
2 Citations (Scopus)

Improved tendon healing using bFGF, BMP-12 and TGFβ1 in a rat model

Majewski, M., Heisterbach, P., Jaquiéry, C., Dürselen, L., Todorov, A., Martin, I., Evans, C. H. & Müller, S. A., Jan 1 2018, In : European Cells and Materials. 35, p. 318-334 17 p.

Research output: Contribution to journalArticle

Tendons
Fibroblast Growth Factor 2
Fibroblasts
Transforming Growth Factor beta
Rats
2 Citations (Scopus)

Self-complementary adeno-associated virus-mediated interleukin-1 receptor antagonist gene delivery for the treatment of osteoarthritis: Test of efficacy in an equine model

Watson Levings, R. S., Smith, A. D., Broome, T. A., Rice, B. L., Gibbs, E. P., Myara, D. A., Hyddmark, E. V., Nasri, E., Zarezadeh, A., Levings, P. P., Lu, Y., White, M. E., Dacanay, E. A., Foremny, G. B., Evans, C. H., Morton, A. J., Winter, M., Dark, M. J., Nickerson, D. M., Colahan, P. T. & 1 others, Ghivizzani, S. C., Jun 1 2018, In : Human Gene Therapy Clinical Development. 29, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

Dependovirus
Interleukin-1 Receptors
Osteoarthritis
Horses
Joints
2 Citations (Scopus)

State of art and limitations in genetic engineering to induce stable chondrogenic phenotype

Graceffa, V., Vinatier, C., Guicheux, J., Evans, C. H., Stoddart, M., Alini, M. & Zeugolis, D. I., Jan 1 2018, (Accepted/In press) In : Biotechnology Advances.

Research output: Contribution to journalArticle

Genetic engineering
Genetic Engineering
Stem cells
Chondrocytes
Cartilage
9 Citations (Scopus)

The Role of the Paratenon in Achilles Tendon Healing: A Study in Rats

Müller, S. A., Evans, C. H., Heisterbach, P. E. & Majewski, M., Apr 1 2018, In : American Journal of Sports Medicine. 46, 5, p. 1214-1219 6 p.

Research output: Contribution to journalArticle

Achilles Tendon
Tendons
Tears
Collagen
Hematoxylin
2017
5 Citations (Scopus)

Contribution of Implanted, Genetically Modified Muscle Progenitor Cells Expressing BMP-2 to New Bone Formation in a Rat Osseous Defect

De La Vega, R. E., De Padilla, C. L., Trujillo, M., Quirk, N., Porter, R. M., Evans, C. H. & Ferreira, E., 2017, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Osteogenesis
Muscle Cells
Stem Cells
Muscles
Osteocytes
3 Citations (Scopus)

Extended release of proteins following encapsulation in hydroxyapatite/chitosan composite scaffolds for bone tissue engineering applications

Devine, D. M., Hoctor, E., Hayes, J. S., Sheehan, E. & Evans, C. H., Jan 1 2017, (Accepted/In press) In : Materials Science and Engineering C.

Research output: Contribution to journalArticle

Compressive Strength
Biomimetics
Differential Scanning Calorimetry
Chitosan
Biocompatible Materials
2016
8 Citations (Scopus)

Drug delivery to chondrocytes

Evans, C. H., Jan 1 2016, In : Osteoarthritis and Cartilage. 24, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Drug Delivery Systems
Tissue Engineering
Chondrocytes
Drug delivery
Tissue engineering
13 Citations (Scopus)

Effect of a Simple Collagen Type i Sponge for Achilles Tendon Repair in a Rat Model

Müller, S. A., Dürselen, L., Heisterbach, P., Evans, C. H. & Majewski, M., Aug 1 2016, In : American Journal of Sports Medicine. 44, 8, p. 1998-2004 7 p.

Research output: Contribution to journalArticle

Achilles Tendon
Porifera
Tendons
Collagen
Collagen Type I
7 Citations (Scopus)

Improving translation success of cell-based therapies in orthopaedics

Bara, J. J., Herrmann, M., Evans, C. H., Miclau, T., Ratcliffe, A. & Richards, R. G., Jan 1 2016, In : Journal of Orthopaedic Research. 34, 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Orthopedics
Education
Research Personnel
Cell Engineering
7 Citations (Scopus)

Interaction between living bone particles and rhBMP-2 in large segmental defect healing in the rat femur

Liu, F., Wells, J. W., Porter, R. M., Glatt, V., Shen, Z., Schinhan, M., Ivkovic, A., Vrahas, M. S., Evans, C. H. & Ferreira, E., 2016, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

Femur
Bone and Bones
Autografts
Osteogenesis
Immunosuppressive Agents
12 Citations (Scopus)

Reverse dynamization influence of fixator stiffness on the mode and efficiency of large-bone-defect healing at different doses of rhBMP-2

Glatt, V., Bartnikowski, N., Quirk, N., Schuetz, M. & Evans, C. H., Apr 20 2016, In : Journal of Bone and Joint Surgery - American Volume. 98, 8, p. 677-687 11 p.

Research output: Contribution to journalArticle

External Fixators
Bone and Bones
Bony Callus
Porifera
Thigh
13 Citations (Scopus)

Safety and biodistribution assessment of sc-rAAV2.5IL-1Ra administered via intra-articular injection in a mono-iodoacetate-induced osteoarthritis rat model

Wang, G., Evans, C. H., Benson, J. M., Hutt, J. A., Seagrave, J. C., Wilder, J. A., Grieger, J. C., Samulski, R. J. & Terse, P. S., Mar 16 2016, In : Molecular Therapy - Methods and Clinical Development. 3, p. 15052 1 p.

Research output: Contribution to journalArticle

Iodoacetates
Intra-Articular Injections
Osteoarthritis
Interleukin-1 Receptors
Knee
32 Citations (Scopus)

Tissue engineering and regenerative approaches to improving the healing of large bone defects

Verrier, S., Alini, M., Alsberg, E., Buchman, S. R., Kelly, D., Laschke, M. W., Menger, M. D., Murphy, W. L., Stegemann, J. P., Schütz, M., Miclau, T., Stoddart, M. J. & Evans, C. H., Jul 1 2016, In : European Cells and Materials. 32, p. 87-110 24 p.

Research output: Contribution to journalArticle

Tissue Engineering
Tissue engineering
Bone
Bone and Bones
Gene therapy
1 Citation (Scopus)

Why does bone have TERM limits?

Evans, C. H. & Stoddart, M. J., Jun 1 2016, In : Injury. 47, 6, p. 1159-1161 3 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Bone Regeneration
Regenerative Medicine
Tissue Engineering
2015
166 Citations (Scopus)

Biologics for tendon repair

Docheva, D., Müller, S. A., Majewski, M. & Evans, C. H., Apr 1 2015, In : Advanced Drug Delivery Reviews. 84, p. 222-239 18 p.

Research output: Contribution to journalArticle

Biological Products
Tendons
Tendon Injuries
Autografts
Biocompatible Materials
96 Citations (Scopus)

Gene therapy approaches to regenerating the musculoskeletal system

Evans, C. H. & Huard, J., Apr 1 2015, In : Nature Reviews Rheumatology. 11, 4, p. 234-242 9 p.

Research output: Contribution to journalArticle

Musculoskeletal System
Genetic Therapy
Genes
Regeneration
Untranslated RNA
2 Citations (Scopus)

Native, Living Tissues as Cell Seeded Scaffolds

Evans, C. H., Mar 1 2015, In : Annals of Biomedical Engineering. 43, 3, p. 787-795 9 p.

Research output: Contribution to journalArticle

Scaffolds (biology)
Tissue
Orthopedics
Cartilage
Biomimetics
17 Citations (Scopus)

Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle

Liu, F., Ferreira, E., Porter, R. M., Glatt, V., Schinhan, M., Shen, Z., Randolph, M. A., Kirker-Head, C. A., Wehling, C., Vrahas, M. S., Evans, C. H. & Wells, J. W., 2015, In : European Cells and Materials. 30, p. 118-131 14 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Muscle
Sheep
Bone
Rats
2014
20 Citations (Scopus)

Barriers and strategies for the clinical translation of advanced orthopaedic tissue engineering protocols

Madry, H., Alini, M., Stoddart, M. J., Evans, C. H., Miclau, T. & Steiner, S., May 6 2014, In : European Cells and Materials. 27, SUPPL, p. 17-21 5 p.

Research output: Contribution to journalArticle

Orthopedics
Tissue Engineering
Tissue engineering
Health Care Sector
Translational Medical Research

On the shoulders of giants: The future of the Journal of Orthopaedic Research

Alman, B. & Evans, C. H., 2014, In : Journal of Orthopaedic Research. 32, 9, p. 1095-1096 2 p.

Research output: Contribution to journalArticle

Orthopedics
Research
11 Citations (Scopus)

Preclinical toxicity evaluation of AAV for pain: Evidence from human AAV studies and from the pharmacology of analgesic drugs

Pleticha, J., Heilmann, L. F., Evans, C. H., Asokan, A., Samulski, R. J. & Beutler, A. S., 2014, In : Molecular Pain. 10, 1, Article 54.

Research output: Contribution to journalArticle

Dependovirus
Analgesics
Pharmacology
Pain
Transgenes
138 Citations (Scopus)

Progress in intra-articular therapy

Evans, C. H., Kraus, V. B. & Setton, L. A., Jan 2014, In : Nature Reviews Rheumatology. 10, 1, p. 11-22 12 p.

Research output: Contribution to journalArticle

Joints
Therapeutics
Intra-Articular Injections
Lymphatic System
Drug Costs
25 Citations (Scopus)

TNFα and IL-1β influence the differentiation and migration of murine MSCs independently of the NF-κB pathway

Sullivan, C. B., Porter, R. M., Evans, C. H., Ritter, T., Shaw, G., Barry, F. & Murphy, J. M., Aug 27 2014, In : Stem Cell Research and Therapy. 5, 4, 104.

Research output: Contribution to journalArticle

NF-kappa B
Stem cells
Mesenchymal Stromal Cells
Interleukin-1
Tumor Necrosis Factor-alpha
18 Citations (Scopus)

Using genes to facilitate the endogenous repair and regeneration of orthopaedic tissues

Evans, C. H., 2014, In : International Orthopaedics. 38, 9, p. 1761-1769 9 p.

Research output: Contribution to journalArticle

Orthopedics
Regeneration
Genes
Technology Transfer
Veterinary Medicine
2013
40 Citations (Scopus)

Advances in regenerative orthopedics

Evans, C. H., 2013, In : Mayo Clinic Proceedings. 88, 11, p. 1323-1329 7 p.

Research output: Contribution to journalArticle

Orthopedics
Mesenchymal Stromal Cells
Intercellular Signaling Peptides and Proteins
Articular Ligaments
Biological Phenomena
52 Citations (Scopus)

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints

Vo, N., Niedernhofer, L. J., Nasto, L. A., Jacobs, L., Robbins, P. D., Kang, J. & Evans, C. H., Jun 2013, In : Journal of Orthopaedic Research. 31, 6, p. 831-837 7 p.

Research output: Contribution to journalArticle

Osteoarthritis
Spine
Animal Models
Joints
Multipotent Stem Cells
4 Citations (Scopus)

Arginase Treatment Prevents the Recovery of Canine Lymphoma and Osteosarcoma Cells Resistant to the Toxic Effects of Prolonged Arginine Deprivation

Wells, J. W., Evans, C. H., Scott, M. C., Rütgen, B. C., O'Brien, T. D., Modiano, J. F., Cvetkovic, G. & Tepic, S., Jan 30 2013, In : PLoS One. 8, 1, e54464.

Research output: Contribution to journalArticle

Arginase
arginase
osteosarcoma
Poisons
Osteosarcoma
57 Citations (Scopus)

Arthritis gene therapy and its tortuous path into the clinic

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Apr 2013, In : Translational Research. 161, 4, p. 205-216 12 p.

Research output: Contribution to journalArticle

Gene therapy
Osteoarthritis
Genetic Therapy
Arthritis
Joints
29 Citations (Scopus)

Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds

Florine, E. M., Miller, R. E., Porter, R. M., Evans, C. H., Kurz, B. & Grodzinsky, A. J., Jan 2013, In : Cartilage. 4, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Chondrogenesis
Scaffolds (biology)
Hydrogels
Mesenchymal Stromal Cells
Sepharose
40 Citations (Scopus)

Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow

Ferreira, E., Porter, R. M., Wehling, N., O'Sullivan, R. P., Liu, F., Boskey, A., Estok, D. M., Harris, M. B., Vrahas, M. S., Evans, C. H. & Wells, J. W., Oct 11 2013, In : Journal of Biological Chemistry. 288, 41, p. 29494-29505 12 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Bone
Durapatite
Bone Marrow
7 Citations (Scopus)
Angiotensin II Type 1 Receptor Blockers
Transforming Growth Factor beta1
Platelet-Rich Plasma
Losartan
Contusions
2012
12 Citations (Scopus)

Design, characterisation and in vivo testing of a new, adjustable stiffness, external fixator for the rat femur

Glatt, V., Evans, C. H. & Matthys, R., Jan 2012, In : European Cells and Materials. 23, p. 289-299 11 p.

Research output: Contribution to journalArticle

External Fixators
Thigh
Femur
Rats
Stiffness
33 Citations (Scopus)

Effect of BMP-12, TGF-β1 and autologous conditioned serum on growth factor expression in Achilles tendon healing

Heisterbach, P. E., Todorov, A., Flückiger, R., Evans, C. H. & Majewski, M., 2012, In : Knee Surgery, Sports Traumatology, Arthroscopy. 20, 10, p. 1907-1914 8 p.

Research output: Contribution to journalArticle

Achilles Tendon
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Tendons
Serum
23 Citations (Scopus)

Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair

Liu, F., Porter, R. M., Wells, J., Glatt, V., Pilapil, C. & Evans, C. H., Jul 2012, In : Journal of Orthopaedic Research. 30, 7, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Transplants
Muscles
Bone and Bones
Genes
23 Citations (Scopus)

EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors

Evans, C. H., Liu, F., Porter, R. M., O'Sullivan, R. P., Merghoub, T., Lunsford, E. P., Robichaud, K., Van Valen, F., Lessnick, S. L., Gebhardt, M. C. & Wells, J. W., Oct 1 2012, In : Clinical Cancer Research. 18, 19, p. 5341-5351 11 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Cytotoxic T-Lymphocytes
T-Lymphocytes
Peptides
Neoplasms
70 Citations (Scopus)

Gene delivery to bone

Evans, C. H., Sep 2012, In : Advanced Drug Delivery Reviews. 64, 12, p. 1331-1340 10 p.

Research output: Contribution to journalArticle

Bone and Bones
Genes
Mesenchymal Stromal Cells
Transgenes
Osteogenesis Imperfecta
27 Citations (Scopus)

Genetic mismatch affects the immunosuppressive properties of mesenchymal stem cells in vitro and their ability to influence the course of collagen-induced arthritis

Sullivan, C., Murphy, J. M., Griffin, M. D., Porter, R. M., Evans, C. H., O'Flatharta, C., Shaw, G. & Barry, F., Jul 19 2012, In : Arthritis Research and Therapy. 14, 4, R167.

Research output: Contribution to journalArticle

Experimental Arthritis
Immunosuppressive Agents
Mesenchymal Stromal Cells
Interleukin-17
Interleukin-4
31 Citations (Scopus)

Improved healing of large segmental defects in the rat femur by reverse dynamization in the presence of bone morphogenetic protein-2

Glatt, V., Miller, M., Ivkovic, A., Liu, F., Parry, N., Griffin, D., Vrahas, M. & Evans, C. H., Nov 21 2012, In : Journal of Bone and Joint Surgery - Series A. 94, 22, p. 2063-2073 11 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Femur
Bone and Bones
X-Ray Microtomography
External Fixators