• 20782 Citations
  • 82 Scopus h-Index
1976 …2020

Research output per year

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Research Output

1999

Joint efforts: Tackling arthritis using gene therapy

Evans, C. H., Rediske, J. J., Abramson, S. B. & Robbins, P. D., Jan 1 1999, In : Molecular Medicine Today. 5, 4, p. 148-151 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Lessons learned from gene transfer approaches

Evans, C. H., Ghivizzani, S. C., Lechman, E. R., Mi, Z., Jaffurs, D. & Robbins, P. D., Dec 1 1999, In : Arthritis Research. 1, 1, p. 21-24 4 p.

Research output: Contribution to journalReview article

13 Scopus citations

Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: An in vivo study of adenovirus-mediated transfer of the human transforming growth factor β1 encoding gene

Nishida, K., Kang, J. D., Gilbertson, L. G., Moon, S. H., Suh, J. K., Vogt, M. T., Robbins, P. D. & Evans, C. H., Dec 1 1999, In : Spine. 24, 23, p. 2419-2425 7 p.

Research output: Contribution to journalArticle

265 Scopus citations

Nitric oxide in osteoarthritis

Studer, R., Jaffurs, D., Stefanovic-Racic, M., Robbins, P. D. & Evans, C. H., Jul 1999, In : Osteoarthritis and Cartilage. 7, 4, p. 377-379 3 p.

Research output: Contribution to journalArticle

151 Scopus citations

Potential treatment of osteoarthritis by gene therapy

Evans, C. H. & Robbins, P. D., Jan 1 1999, In : Rheumatic Disease Clinics of North America. 25, 2, p. 333-344 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging

Oyama, M., Tatlock, A., Fukuta, S., Kavalkovich, K., Nishimura, K., Johnstone, B., Robbins, P. D., Evans, C. H. & Niyibizi, C., Mar 1 1999, In : Gene Therapy. 6, 3, p. 321-329 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

The role of gene therapy: Fact or fiction?

Muzzonigro, T. S., Ghivizzani, S. C., Robbins, P. D. & Evans, C. H., Jan 1 1999, In : Clinics in Sports Medicine. 18, 1, p. 223-239 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Transfer of LacZ marker gene to the meniscus

Goto, H., Shuler, F. D., Lamsam, C., Moller, H. D., Niyibizi, C., Fu, F. H., Robbins, P. D. & Evans, C. H., Jul 1 1999, In : Journal of Bone and Joint Surgery - Series A. 81, 7, p. 918-925 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Trisomy 7 in synovial fibroblasts obtained from arthritic joints

Weiss, K. R., Georgescu, H. I., Gollin, S. M., Kang, R. & Evans, C. H., Jan 1 1999, In : Inflammation Research. 48, SUPPL. 2, p. S132-S133

Research output: Contribution to journalArticle

3 Scopus citations
1998

A 1998 status report on orthopedic gene therapy

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 1 1998, In : Current Opinion in Orthopaedics. 9, 6, p. 75-80 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Adenovirus-mediated gene transfer to nucleus pulposus cells implications for the treatment of intervertebral disc degeneration

Nishida, K., Kang, J. D., Suh, J. K., Robbins, P. D., Evans, C. H. & Gilbertson, L. G., Nov 15 1998, In : Spine. 23, 22, p. 2437-2443 7 p.

Research output: Contribution to journalArticle

132 Scopus citations

Blocking cytokines with genes

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jul 1998, In : Journal of Leukocyte Biology. 64, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Differences in nitric oxide production by superficial and deep human articular chondrocytes: Implications for proteoglycan turnover in inflammatory joint diseases

Häuselmann, H. J., Stefanovic-Racic, M., Michel, B. A. & Evans, C. H., Feb 1 1998, In : Journal of Immunology. 160, 3, p. 1444-1448 5 p.

Research output: Contribution to journalArticle

66 Scopus citations
270 Scopus citations

Generation of nitric oxide by lapine meniscal cells and its effect on matrix metabolism: Stimulation of collagen production by arginine

Cao, M., Stefanovic-Racic, M., Georgescu, H. I., Miller, L. A. & Evans, C. H., Jan 1 1998, In : Journal of Orthopaedic Research. 16, 1, p. 104-111 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Gene therapy for rheumatoid arthritis

Robbins, P. D., Evans, C. H. & Chernajovsky, Y., Jan 1 1998, In : Springer Seminars in Immunopathology. 20, 1-2, p. 197-209 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Gene therapy in arthritis

Whalen, J. D., Robbins, P. D. & Evans, C. H., Nov 1 1998, In : IDrugs. 1, 7, p. 802-806 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Gene therapy in autoimmune diseases

Evans, C. H., Whalen, J. D., Ghivizzani, S. C. & Robbins, P. D., Jan 1 1998, In : Annals of the rheumatic diseases. 57, 3, p. 125-127 3 p.

Research output: Contribution to journalShort survey

Open Access
23 Scopus citations

Gene therapy in sports medicine

Lamsam, C., Fu, F. H., Robbins, P. D. & Evans, C. H., Mar 19 1998, In : Sports Medicine. 25, 2, p. 73-77 5 p.

Research output: Contribution to journalReview article

15 Scopus citations

Gene therapy in sports medicine

Lattermann, C., Baltzer, A. W. A., Whalen, J. D., Evans, C. H., Robbins, P. D. & Fu, F. H., Jan 1 1998, In : Sports medicine and arthroscopy review. 6, 2, p. 83-88 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Potential role for gene therapy in the enhancement of fracture healing

Niyibizi, C., Baltzer, A., Lattermann, C., Oyama, M., Whalen, J. D., Robbins, P. D. & Evans, C. H., Jan 1 1998, In : Clinical orthopaedics and related research. 355 SUPPL., p. S148-S153

Research output: Contribution to journalArticle

76 Scopus citations

The Human Genome Project: implications for the treatment of musculoskeletal disease.

Jaffurs, D. & Evans, C. H., Jan 1 1998, In : The Journal of the American Academy of Orthopaedic Surgeons. 6, 1, p. 1-14 14 p.

Research output: Contribution to journalReview article

6 Scopus citations
1997

Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10

Doughty, L. A., Patrene, K. D., Evans, C. H., Boggs, S. S. & Robbins, P. D., Jan 1 1997, In : Gene Therapy. 4, 3, p. 252-257 6 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: Implications for arthritis gene therapy

Ghivizzani, S. C., Lechman, E. R., Tio, C., Mule, K. M., Chada, S., McCormack, J. E., Evans, C. H. & Robbins, P. D., Jan 1 1997, In : Gene Therapy. 4, 9, p. 977-982 6 p.

Research output: Contribution to journalArticle

Open Access
88 Scopus citations

Effect of growth factors on the proliferation of ligament fibroblasts from skeletally mature rabbits

Scherping, S. C., Schmidt, C. C., Georgescu, H. I., Kwoh, C. K., Evans, C. H. & Woo, S. L. Y., 1997, In : Connective Tissue Research. 36, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

102 Scopus citations

Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse

Balk, M. L., Bray, J., Day, C., Epperly, M., Greenberger, J., Evans, C. H. & Niyibizi, C., Jul 1 1997, In : Bone. 21, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: A feasibility study

Kang, R., Marui, T., Ghivizzani, S. C., Nita, I. M., Georgescu, H. I., Suh, J. K., Robbins, P. D. & Evans, C. H., Jan 1 1997, In : Osteoarthritis and Cartilage. 5, 2, p. 139-143 5 p.

Research output: Contribution to journalArticle

118 Scopus citations

Gene therapy for arthritis

Evans, C. H. & Robbins, P. D., Jul 23 1997, In : Expert Opinion on Investigational Drugs. 6, 7, p. 837-840 4 p.

Research output: Contribution to journalReview article

3 Scopus citations

Gene therapy for arthritis: Principles and clinical practice

Kang, R., Ghivizzani, S. C., Herndon, J. H., Robbinst, P. D. & Evans, C. H., Jan 1 1997, In : Biochemical Society Transactions. 25, 2, p. 533-537 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Gene transfer to joints

Robbins, P. D., Ghivizzani, S. C. & Evans, C. H., Jan 1 1997, In : Drug News and Perspectives. 10, 5, p. 283-292 10 p.

Research output: Contribution to journalReview article

5 Scopus citations

Gene transfer to the patellar tendon

Gerich, T. G., Kang, R., Fu, F. H., Robbins, P. D. & Evans, C. H., Jan 1 1997, In : Knee Surgery, Sports Traumatology, Arthroscopy. 5, 2, p. 118-123 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Gentransfer in die Patellarsehne von Kaninchen: Eine vorbereitende Studie zur lokoregionaren Expression von Wachstumsfaktoren

Translated title of the contribution: Gene transfer to the patellar tendon - An experimental study in rabbitsGerich, T. G., Ghivizani, S., Fu, F. H., Robbins, P. D. & Evans, C. H., Jul 16 1997, In : Wiener Klinische Wochenschrift. 109, 11, p. 384-389 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Getting genes into human synovium.

Evans, C. H. & Robbins, P. D., Nov 1 1997, In : The Journal of rheumatology. 24, 11, p. 2061-2063 3 p.

Research output: Contribution to journalComment/debate

12 Scopus citations

Human IL-1Ra Gene Transfer into Human Synovial Fibroblasts Is Chondroprotective

Müller-Ladner, U., Roberts, C. R., Franklin, B. N., Gay, R. E., Robbins, P. D., Evans, C. H. & Gay, S., Apr 1 1997, In : Journal of Immunology. 158, 7, p. 3492-3498 7 p.

Research output: Contribution to journalArticle

141 Scopus citations

Identification of inducible nitric oxide synthase in human macrophages surrounding loosened hip prostheses

Watkins, S. C., Macaulay, W., Turner, D., Kang, R., Rubash, H. E. & Evans, C. H., Apr 19 1997, In : American Journal of Pathology. 150, 4, p. 1199-1206 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Interleukin-1α as an autocrine regulator in rabbit synovial fibroblasts

Engle, J. M., Georgescu, H. I. & Evans, C. H., Jan 1 1997, In : Inflammation Research. 46, SUPPL. 2, p. S175-S176

Research output: Contribution to journalArticle

3 Scopus citations

In vitro transfer von genen in spinale gewebe

Translated title of the contribution: In vitro transfer of genes into spinal tissuesReinecke, J. A., Wehling, P., Robbins, P., Evans, C. H., Sager, M., Schulze-Allen, G. & Koch, H., Jan 1 1997, In : Zeitschrift fur Orthopadie und Ihre Grenzgebiete. 135, 5, p. 412-416 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

In vivo suppression of early experimental osteoarthritis by interleukin- 1 receptor antagonist using gene therapy

Pelletier, J. P., Caron, J. P., Evans, C., Robbins, P. D., Georgescu, H. I., Jovanovic, D., Fernandes, J. C. & Martel-Pelletier, J., Jun 20 1997, In : Arthritis and rheumatism. 40, 6, p. 1012-1019 8 p.

Research output: Contribution to journalArticle

304 Scopus citations

Moglichkeiten der Gentherapie bei traumatischen und degenerativen Gelenklasionen. Aktueller Stand experimenteller und erster klinischer Anwendungen

Translated title of the contribution: Possibilities of gene therapy in traumatic and degenerative lesions of the joints. Current experimental status and preliminary clinical applicationsGerich, T. G., Lobenhoffer, P., Fu, F. H., Robbins, P. D. & Evans, C. H., Jan 1 1997, In : Orthopade. 26, 5, p. 450-458 9 p.

Research output: Contribution to journalReview article

7 Scopus citations

Nitric oxide and proteoglycan turnover in rabbit articular cartilage

Stefanovic-Racic, M., Mollers, M. O., Miller, L. A. & Evans, C. H., May 1 1997, In : Journal of Orthopaedic Research. 15, 3, p. 442-449 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: Prolyl hydroxylase as a possible target

Cao, M., Westerhausen-Larson, A., Niyibizi, C., Kavalkovich, K., Georgescu, H. I., Rizzo, C. F., Hebda, P. A., Stefanovic-Racic, M. & Evans, C. H., May 15 1997, In : Biochemical Journal. 324, 1, p. 305-310 6 p.

Research output: Contribution to journalArticle

149 Scopus citations

Progress in development of herpes simplex virus gene vectors for treatment of rheumatoid arthritis

Glorioso, J. C., Krisky, D., Marconi, P., Oligino, T., Ghivizzani, S. C., Robbins, P. D., Schmidt, M. C., Goins, W. F. & Evans, C., Aug 11 1997, In : Advanced Drug Delivery Reviews. 27, 1, p. 41-57 17 p.

Research output: Contribution to journalReview article

26 Scopus citations

The natural history of the anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokine and keratan sulfate concentrations

Cameron, M., Buchgraber, A., Passler, H., Vogt, M., Thonar, E., Fu, F. & Evans, C. H., Jan 1 1997, In : American Journal of Sports Medicine. 25, 6, p. 751-754 4 p.

Research output: Contribution to journalArticle

166 Scopus citations

Toward a biochemical understanding of human intervertebral disc degeneration and herniation: Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases

Kang, J. D., Stefanovic-Racic, M., McIntyre, L. A., Georgescu, H. I. & Evans, C. H., May 15 1997, In : Spine. 22, 10, p. 1065-1073 9 p.

Research output: Contribution to journalArticle

333 Scopus citations

Transfer of genes to chondrocytic cells of the lumbar spine: Proposal for a treatment strategy of spinal disorders by local gene therapy

Wehling, P., Schulitz, K. P., Robbins, P. D., Evans, C. H. & Reinecke, J. A., May 15 1997, In : Spine. 22, 10, p. 1092-1097 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Virusvermittelter Gentransfer in die Patellarsehne. Eine experimentelle Studie am Kaninchen

Translated title of the contribution: Virally mediated gene transfer to the patellar tendon. An experimental study on rabbitsGerich, T. G., Lobenhoffer, H. P., Fu, F. H., Robbins, P. D. & Evans, C. H., May 1 1997, In : Unfallchirurg. 100, 5, p. 354-362 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
1996

Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis

Evans, C. H., Mankin, H. J., Ferguson, J., Robbins, P. D., Ghivizzani, S. C., Herndon, J. H., Kang, R., Bahnson, A. B., Barranger, J. A., Elders, E. M., Gay, S., Tomaino, M. M., Wasko, M. C., Watkins, S. C., Whiteside, T. L., Glorioso, J. C., Lotze, M. T. & Wright, T. M., Jun 20 1996, In : Human gene therapy. 7, 10, p. 1261-1306 46 p.

Research output: Contribution to journalReview article

208 Scopus citations

Direct gene delivery to synovium: An evaluation of potential vectors in vitro and in vivo

Nita, I., Ghivizzani, S. C., Galea-Lauri, J., Bandara, G., Georgescu, H. I., Robbins, P. D. & Evans, C. H., May 1 1996, In : Arthritis and rheumatism. 39, 5, p. 820-828 9 p.

Research output: Contribution to journalArticle

163 Scopus citations

Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts

Lin, C. W., Robbins, P. D., Georgescu, H. I. & Evans, C. H., Feb 25 1996, In : Experimental Cell Research. 223, 1, p. 117-126 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Gene transfer to the rabbit patellar tendon: Potential for genetic enhancement of tendon and ligament healing

Gerich, T. G., Kang, R., Fu, F. H., Robbins, P. D. & Evans, C. H., Dec 1 1996, In : Gene Therapy. 3, 12, p. 1089-1093 5 p.

Research output: Contribution to journalArticle

88 Scopus citations