Research Output

2017

Identifying therapeutic targets for Alzheimer's disease with big data

Taner, N., Apr 1 2017, In : Neurodegenerative disease management. 7, 2, p. 101-105 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

Jiang, P., Gan, M., Yen, S. H., McLean, P. J. & Dickson, D. W., Dec 1 2017, In : Scientific Reports. 7, 1, 7690.

Research output: Contribution to journalArticle

18 Scopus citations

Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with Rack1 on polyribosomes

Russo, A., Scardigli, R., Regina, F. L., Murray, M. E., Romano, N., Dickson, D. W., Wolozin, B., Cattaneo, A. & Ceci, M., Apr 15 2017, In : Human Molecular Genetics. 26, 8, p. 1407-1418 12 p., ddx035.

Research output: Contribution to journalArticle

19 Scopus citations

In-depth clinico-pathological examination of RNA foci in a large cohort of C9ORF72 expansion carriers

DeJesus-Hernandez, M., Finch, N. C. A., Wang, X., Gendron, T. F., Bieniek, K. F., Heckman, M. G., Vasilevich, A., Murray, M. E., Rousseau, L., Weesner, R., Lucido, A., Parsons, M., Chew, J., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C., Boeve, B. F., Graff-Radford, N. R., de Boer, J. & 6 others, Asmann, Y. W., Petrucelli, L., Boylan, K. B., Dickson, D. W., van Blitterswijk, M. & Rademakers, R., Aug 1 2017, In : Acta neuropathologica. 134, 2, p. 255-269 15 p.

Research output: Contribution to journalArticle

27 Scopus citations

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

Volta, M., Beccano-Kelly, D. A., Paschall, S. A., Cataldi, S., Macisaac, S. E., Kuhlmann, N., Kadgien, C. A., Tatarnikov, I., Fox, J., Khinda, J., Mitchell, E., Bergeron, S., Melrose, H., Farrer, M. J. & Milnerwood, A. J., Sep 20 2017, In : eLife. 6, e28377.

Research output: Contribution to journalArticle

20 Scopus citations

Intra-and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery

Yoon, H., Belmonte, K. C., Kasten, T., Bateman, R. & Kim, J., Dec 1 2017, In : Scientific Reports. 7, 1, 12720.

Research output: Contribution to journalArticle

3 Scopus citations

Investigation of endocytic pathways for the internalization of exosome-associated oligomeric alpha-synuclein

Delenclos, M., Trendafilova, T., Mahesh, D., Baine, A. M., Moussaud, S., Yan, I. K., Patel, T. & McLean, P. J., Mar 30 2017, In : Frontiers in Neuroscience. 11, MAR, 172.

Research output: Contribution to journalArticle

28 Scopus citations

Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience

for the Alzheimer's Disease Neuroimaging Initative, Nov 29 2017, In : Genome medicine. 9, 1, 100.

Research output: Contribution to journalArticle

17 Scopus citations

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

Evers, B. M., Rodriguez-Navas, C., Tesla, R. J., Prange-Kiel, J., Wasser, C. R., Yoo, K. S., McDonald, J., Cenik, B., Ravenscroft, T. A., Plattner, F., Rademakers, R. V., Yu, G., White, C. L. & Herz, J., Sep 12 2017, In : Cell Reports. 20, 11, p. 2565-2574 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Lipocalin-2 protects the brain during inflammatory conditions

Kang, S., Ren, Y., Liu, C-C., Kurti, A., Baker, K. E., Bu, G. D., Asmann, Y. & Fryer, J. D., Jan 10 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

31 Scopus citations

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Wojtas, A. M., Kang, S. S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C. C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G., Carare, R. O. & Fryer, J. D., Aug 15 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

Research output: Contribution to journalArticle

33 Scopus citations

LRRK2 mouse models: Dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis

Volta, M. & Melrose, H. L., Feb 8 2017, In : Biochemical Society Transactions. 45, 1, p. 113-122 10 p.

Research output: Contribution to journalReview article

14 Scopus citations

Mitochondrial membrane protein-associated neurodegeneration

Deutschländer, A., Konno, T. & Ross, O. A., 2017, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

4 Scopus citations

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

Fiesel, F. C., James, E. D., Hudec, R. & Springer, W., 2017, In : Oncotarget. 8, 63, p. 106233-106248 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Multifaceted peptide assisted one-pot synthesis of gold nanoparticles for plectin-1 targeted gemcitabine delivery in pancreatic cancer

Pal, K., Al-Suraih, F., Gonzalez-Rodriguez, R., Dutta, S. K., Wang, E., Kwak, H. S., Caulfield, T. R., Coffer, J. L. & Bhattacharya, S., Oct 28 2017, In : Nanoscale. 9, 40, p. 15622-15634 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Multisite assessment of aging-related tau astrogliopathy (ARTAG)

Kovacs, G. G., Xie, S. X., Lee, E. B., Robinson, J. L., Caswell, C., Irwin, D. J., Toledo, J. B., Johnson, V. E., Smith, D. H., Alafuzoff, I., Attems, J., Bencze, J., Bieniek, K. F., Bigio, E. H., Bodi, I., Budka, H., Dickson, D. W., Dugger, B. N., Duyckaerts, C., Ferrer, I. & 42 others, Forrest, S. L., Gelpi, E., Gentleman, S. M., Giaccone, G., Grinberg, L. T., Halliday, G. M., Hatanpaa, K. J., Hof, P. R., Hofer, M., Hortobágyi, T., Ironside, J. W., King, A., Kofler, J., Kövari, E., Kril, J. J., Love, S., Mackenzie, I. R., Mao, Q., Matej, R., McLean, C., Munoz, D. G., Murray, M. E., Neltner, J., Nelson, P. T., Ritchie, D., Rodriguez, R. D., Rohan, Z., Rozemuller, A., Sakai, K., Schultz, C., Seilhean, D., Smith, V., Tacik, P., Takahashi, H., Takao, M., Thal, D. R., Weis, S., Wharton, S. B., White, C. L., Woulfe, J. M., Yamada, M. & Trojanowski, J. Q., 2017, In : Journal of Neuropathology and Experimental Neurology. 76, 7, p. 605-619 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

Yuan, H., Jiang, W., von Roemeling, C. A., Qie, Y., Liu, X., Chen, Y., Wang, Y., Wharen, R. E., Yun, K., Bu, G. D., Knutson, K. L. & Kim, Y. S. B., May 1 2017, (Accepted/In press) In : Nature Nanotechnology.

Research output: Contribution to journalArticle

52 Scopus citations

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

Kawamata, H., Peixoto, P., Konrad, C., Palomo, G., Bredvik, K., Gerges, M., Valsecchi, F., Petrucelli, L., Ravits, J. M., Starkov, A. & Manfredi, G., May 8 2017, In : Molecular neurodegeneration. 12, 1, 37.

Research output: Contribution to journalArticle

16 Scopus citations

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Delenclos, M., Faroqi, A. H., Yue, M., Kurti, A., Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Fryer, J. D. & McLean, P. J., Jun 23 2017, In : Acta Neuropathologica Communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

5 Scopus citations

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers

Lee, S. E., Sias, A. C., Mandelli, M. L., Brown, J. A., Brown, A. B., Khazenzon, A. M., Vidovszky, A. A., Zanto, T. P., Karydas, A. M., Pribadi, M., Dokuru, D., Coppola, G., Geschwind, D. H., Rademakers, R., Gorno-Tempini, M. L., Rosen, H. J., Miller, B. L. & Seeley, W. W., 2017, In : NeuroImage: Clinical. 14, p. 286-297 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Neuropathology of Parkinson disease

Dickson, D. W., 2017, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

77 Scopus citations

Occurrence of Crohn's disease with Parkinson's disease

Fujioka, S., Curry, S. E., Kennelly, K., Tacik, P., Heckman, M. G., Tsuboi, Y., Strongosky, A. J., Van Gerpen, J. A., Uitti, R. J., Ross, O. A., Ikezu, T. & Wszolek, Z. K., Apr 1 2017, In : Parkinsonism and Related Disorders. 37, p. 116-117 2 p.

Research output: Contribution to journalLetter

13 Scopus citations
4 Scopus citations

P62 pathology model in the rat substantia nigra with filamentous inclusions and progressive neurodegeneration

Jackson, K. L., Lin, W. L., Miriyala, S., Dayton, R. D., Panchatcharam, M., McCarthy, K. J., Castanedes-Casey, M., Dickson, D. W. & Klein, R. L., Jan 2017, In : PloS one. 12, 1, e0169291.

Research output: Contribution to journalArticle

8 Scopus citations

Parkinson's disease susceptibility variants and severity of Lewy body pathology

Heckman, M. G., Kasanuki, K., Diehl, N. N., Koga, S., Soto, A., Murray, M. E., Dickson, D. W. & Ross, O. A., 2017, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

5 Scopus citations

Parkinson’s disease: experimental models and reality

Jiang, P. & Dickson, D. W., Nov 18 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-20 20 p.

Research output: Contribution to journalArticle

35 Scopus citations

Pathology of neurodegenerative diseases

Dugger, B. N. & Dickson, D. W., Jan 1 2017, In : Cold Spring Harbor perspectives in biology. 9, 7, a028035.

Research output: Contribution to journalReview article

64 Scopus citations

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

Nielsen, H. M., Chen, K., Lee, W., Chen, Y., Bauer, R. J., Reiman, E., Caselli, R. & Bu, G., Jan 30 2017, In : Alzheimer's Research and Therapy. 9, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy

Mishima, T., Koga, S., Lin, W. L., Kasanuki, K., Castanedes-Casey, M., Wszolek, Z. K., Oh, S. J., Tsuboi, Y. & Dickson, D. W., Jul 21 2017, (Accepted/In press) In : Journal of Neuropathology and Experimental Neurology.

Research output: Contribution to journalArticle

15 Scopus citations

Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis

C9ORF72 Neurofilament Study Group, Jul 2017, In : Annals of neurology. 82, 1, p. 139-146 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
72 Scopus citations

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S. U., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G. E., Kang, H., Ham, S., Kam, T. I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F., Springer, W., Dawson, V. L., Shin, J. H. & 1 others, Dawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journalArticle

54 Scopus citations

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Gendron, T. F., Chew, J., Stankowski, J. N., Hayes, L. R., Zhang, Y. J., Prudencio, M., Carlomagno, Y., Daughrity, L. M., Jansen-West, K., Perkerson, E. A., O'Raw, A., Cook, C., Pregent, L., Belzil, V., Van Blitterswijk, M., Tabassian, L. J., Lee, C. W., Yue, M., Tong, J., Song, Y. & 59 others, Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Rademakers, R., Fryer, J. D., Rush, B. K., Pedraza, O., Caputo, A. M., Desaro, P., Palmucci, C., Robertson, A., Heckman, M. G., Diehl, N. N., Wiggs, E., Tierney, M., Braun, L., Farren, J., Lacomis, D., Ladha, S., Fournier, C. N., McCluskey, L. F., Elman, L. B., Toledo, J. B., McBride, J. D., Tiloca, C., Morelli, C., Poletti, B., Solca, F., Prelle, A., Wuu, J., Jockel-Balsarotti, J., Rigo, F., Ambrose, C., Datta, A., Yang, W., Raitcheva, D., Antognetti, G., McCampbell, A., Van Swieten, J. C., Miller, B. L., Boxer, A. L., Brown, R. H., Bowser, R., Miller, T. M., Trojanowski, J. Q., Grossman, M., Berry, J. D., Hu, W. T., Ratti, A., Traynor, B. J., Disney, M. D., Benatar, M., Silani, V., Glass, J. D., Floeter, M. K., Rothstein, J. D., Boylan, K. B. & Petrucelli, L., Mar 29 2017, In : Science translational medicine. 9, 383, eaai7866.

Research output: Contribution to journalArticle

58 Scopus citations

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

Coyne, A. N., Lorenzini, I., Chou, C. C., Torvund, M., Rogers, R. S., Starr, A., Zaepfel, B. L., Levy, J., Johannesmeyer, J., Schwartz, J. C., Nishimune, H., Zinsmaier, K., Rossoll, W., Sattler, R. & Zarnescu, D. C., Oct 3 2017, In : Cell reports. 21, 1, p. 110-125 16 p.

Research output: Contribution to journalArticle

26 Scopus citations

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

Valdez, C., Wong, Y. C., Schwake, M., Bu, G. D., Wszolek, Z. K. & Krainc, D., Dec 1 2017, In : Human Molecular Genetics. 26, 24, p. 4861-4872 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sims, R., Van Der Lee, S. J., Naj, A. C., Bellenguez, C., Badarinarayan, N., Jakobsdottir, J., Kunkle, B. W., Boland, A., Raybould, R., Bis, J. C., Martin, E. R., Grenier-Boley, B., Heilmann-Heimbach, S., Chouraki, V., Kuzma, A. B., Sleegers, K., Vronskaya, M., Ruiz, A., Graham, R. R., Olaso, R. & 426 others, Hoffmann, P., Grove, M. L., Vardarajan, B. N., Hiltunen, M., Nöthen, M. M., White, C. C., Hamilton-Nelson, K. L., Epelbaum, J., Maier, W., Choi, S. H., Beecham, G. W., Dulary, C., Herms, S., Smith, A. V., Funk, C. C., Derbois, C., Forstner, A. J., Ahmad, S., Li, H., Bacq, D., Harold, D., Satizabal, C. L., Valladares, O., Squassina, A., Thomas, R., Brody, J. A., Qu, L., Sánchez-Juan, P., Morgan, T., Wolters, F. J., Zhao, Y., Garcia, F. S., Denning, N., Fornage, M., Malamon, J., Naranjo, M. C. D., Majounie, E., Mosley, T. H., Dombroski, B., Wallon, D., Lupton, M. K., Dupuis, J., Whitehead, P., Fratiglioni, L., Medway, C., Jian, X., Mukherjee, S., Keller, L., Brown, K., Lin, H., Cantwell, L. B., Panza, F., McGuinness, B., Moreno-Grau, S., Burgess, J. D., Solfrizzi, V., Proitsi, P., Adams, H. H., Allen, M., Seripa, D., Pastor, P., Cupples, L. A., Price, N. D., Hannequin, D., Frank-García, A., Levy, D., Chakrabarty, P., Caffarra, P., Giegling, I., Beiser, A. S., Giedraitis, V., Hampel, H., Garcia, M. E., Wang, X., Lannfelt, L., Mecocci, P., Eiriksdottir, G., Crane, P. K., Pasquier, F., Boccardi, V., Henández, I., Barber, R. C., Scherer, M., Tarraga, L., Adams, P. M., Leber, M., Chen, Y., Albert, M. S., Riedel-Heller, S., Emilsson, V., Beekly, D., Braae, A., Schmidt, R., Blacker, D., Masullo, C., Schmidt, H., Doody, R. S., Spalletta, G., Longstreth, W. T., Fairchild, T. J., Bossù, P., Lopez, O. L., Frosch, M. P., Sacchinelli, E., Ghetti, B., Yang, Q., Huebinger, R. M., Jessen, F., Li, S., Kamboh, M. I., Morris, J. C., Sotolongo-Grau, O., Katz, M. J., Corcoran, C., Dunstan, M., Braddel, A., Thomas, C., Meggy, A., Marshall, R., Gerrish, A., Chapman, J., Aguilar, M., Taylor, S., Hill, M., Fairén, M. D., Hodges, A., Vellas, B., Soininen, H., Kloszewska, I., Daniilidou, M., Uphill, J., Patel, Y., Hughes, J. T., Lord, J., Turton, J., Hartmann, A. M., Cecchetti, R., Fenoglio, C., Serpente, M., Arcaro, M., Caltagirone, C., Orfei, M. D., Ciaramella, A., Pichler, S., Mayhaus, M., Gu, W., Lleó, A., Fortea, J., Blesa, R., Barber, I. S., Brookes, K., Cupidi, C., Maletta, R. G., Carrell, D., Sorbi, S., Moebus, S., Urbano, M., Pilotto, A., Kornhuber, J., Bosco, P., Todd, S., Craig, D., Johnston, J., Gill, M., Lawlor, B., Lynch, A., Fox, N. C., Hardy, J., Albin, R. L., Apostolova, L. G., Arnold, S. E., Asthana, S., Atwood, C. S., Baldwin, C. T., Barnes, L. L., Barral, S., Beach, T. G., Becker, J. T., Bigio, E. H., Bird, T. D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Burns, J. M., Buxbaum, J. D., Cairns, N. J., Cao, C., Carlson, C. S., Carlsson, C. M., Carney, R. M., Carrasquillo, M. M., Carroll, S. L., Diaz, C. C., Chui, H. C., Clark, D. G., Cribbs, D. H., Crocco, E. A., Decarli, C., Dick, M., Duara, R., Evans, D. A., Faber, K. M., Fallon, K. B., Fardo, D. W., Farlow, M. R., Ferris, S., Foroud, T. M., Galasko, D. R., Gearing, M., Geschwind, D. H., Gilbert, J. R., Graff-Radford, N. R., Green, R. C., Growdon, J. H., Hamilton, R. L., Harrell, L. E., Honig, L. S., Huentelman, M. J., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Abner, E., Jin, L. W., Jun, G., Karydas, A., Kaye, J. A., Kim, R., Kowall, N. W., Kramer, J. H., Laferla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lunetta, K. L., Lyketsos, C. G., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Murrell, J. R., Myers, A. J., O'Bryant, S., Olichney, J. M., Pankratz, V. S., Parisi, J. E., Paulson, H. L., Perry, W., Peskind, E., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reisberg, B., Reitz, C., Ringman, J. M., Roberson, E. D., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Sager, M. A., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Swerdlow, R. H., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Van Deerlin, V. M., Van Eldik, L. J., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Wilhelmsen, K. C., Williamson, J., Wingo, T. S., Woltjer, R. L., Wright, C. B., Yu, C. E., Yu, L., Garzia, F., Golamaully, F., Septier, G., Engelborghs, S., Vandenberghe, R., De Deyn, P. P., Fernadez, C. M., Benito, Y. A., Thonberg, H., Forsell, C., Lilius, L., Kinhult-Stählbom, A., Kilander, L., Brundin, R., Concari, L., Helisalmi, S., Koivisto, A. M., Haapasalo, A., Dermecourt, V., Fievet, N., Hanon, O., Dufouil, C., Brice, A., Ritchie, K., Dubois, B., Himali, J. J., Keene, C. D., Tschanz, J., Fitzpatrick, A. L., Kukull, W. A., Norton, M., Aspelund, T., Larson, E. B., Munger, R., Rotter, J. I., Lipton, R. B., Bullido, M. J., Hofman, A., Montine, T. J., Coto, E., Boerwinkle, E., Petersen, R. C., Alvarez, V., Rivadeneira, F., Reiman, E. M., Gallo, M., O'Donnell, C. J., Reisch, J. S., Bruni, A. C., Royall, D. R., Dichgans, M., Sano, M., Galimberti, D., St George-Hyslop, P., Scarpini, E., Tsuang, D. W., Mancuso, M., Bonuccelli, U., Winslow, A. R., Daniele, A., Wu, C. K., Peters, O., Nacmias, B., Riemenschneider, M., Heun, R., Brayne, C., Rubinsztein, D. C., Bras, J., Guerreiro, R., Al-Chalabi, A., Shaw, C. E., Collinge, J., Mann, D., Clarimón, J., Sussams, R., Lovestone, S., O'Donovan, M. C., Owen, M. J., Behrens, T. W., Mead, S., Uitterlinden, A. G., Uitterlinden, A. G., Cruchaga, C., Ingelsson, M., Bennett, D. A., Powell, J., Golde, T. E., Graff, C., De Jager, P. L., Morgan, K., Ertekin-Taner, N., Combarros, O., Psaty, B. M., Passmore, P., Younkin, S. G., Berr, C., Gudnason, V., Rujescu, D., Dickson, D. W., Dartigues, J. F., Destefano, A. L., Ortega-Cubero, S., Hakonarson, H., Campion, D., Boada, M., Kauwe, J. K., Farrer, L. A., Van Broeckhoven, C., Ikram, M. A., Jones, L., Haines, J. L., Tzourio, C., Launer, L. J., Escott-Price, V., Mayeux, R., Deleuze, J. F., Amin, N., Goate, A. M., Pericak-Vance, M. A., Holmans, P. A., Van Duijn, C. M., Ramirez, A., Wang, L. S., Lambert, J. C., Seshadri, S., Williams, J. & Schellenberg, G. D., Sep 1 2017, In : Nature Genetics. 49, 9, p. 1373-1384 12 p.

Research output: Contribution to journalArticle

241 Scopus citations

Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: A longitudinal retrospective study

Josephs, K. A., Dickson, D. W., Tosakulwong, N., Weigand, S. D., Murray, M. E., Petrucelli, L., Liesinger, A. M., Senjem, M. L., Spychalla, A. J., Knopman, D. S., Parisi, J. E., Petersen, R. C., Jack, C. R. J. & Whitwell, J. L., 2017, (Accepted/In press) In : The Lancet Neurology.

Research output: Contribution to journalArticle

48 Scopus citations

Reduced orexin immunoreactivity in Perry syndrome and multiple system atrophy

Mishima, T., Kasanuki, K., Koga, S., Castanedes-Casey, M., Wszolek, Z. K., Tsuboi, Y. & Dickson, D. W., Mar 7 2017, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

3 Scopus citations

Regional analysis and genetic association of nigrostriatal degeneration in Lewy body disease

Kasanuki, K., Heckman, M. G., Diehl, N. N., Murray, M. E., Koga, S., Soto, A., Ross, O. A. & Dickson, D. W., Nov 1 2017, In : Movement Disorders. 32, 11, p. 1584-1593 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients

Prudencio, M., Gonzales, P. K., Cook, C., Gendron, T. D., Daughrity, L. M., Song, Y., Ebbert, M. T. W., Van Blitterswijk, M., Zhang, Y., Jansen-West, K., Baker, M. C., Deture, M., Rademakers, R. V., Boylan, K. B., Dickson, D. W., Petrucelli, L. & Link, C. D., Sep 1 2017, In : Human Molecular Genetics. 26, 17, p. 3421-3431 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder

Puschmann, A., Fiesel, F. C., Caulfield, T. R., Hudec, R., Ando, M., Truban, D., Hou, X., Ogaki, K., Heckman, M. G., James, E. D., Swanberg, M., Jimenez-Ferrer, I., Hansson, O., Opala, G., Siuda, J., Boczarska-Jedynak, M., Friedman, A., Koziorowski, D., Rudzińska-Bar, M., Aasly, J. O. & 13 others, Lynch, T., Mellick, G. D., Mohan, M., Silburn, P. A., Sanotsky, Y., Vilarinõ-Güell, C., Farrer, M. J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A. & Springer, W., Jan 1 2017, In : Brain. 140, 6, p. e33

Research output: Contribution to journalLetter

1 Scopus citations

Reply re: "Profile of cognitive impairment and underlying pathology in multiple system atrophy"

Koga, S., Parks, A. & Dickson, D. W., 2017, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

3 Scopus citations

Role of LRP1 in the pathogenesis of Alzheimer's disease: Evidence from clinical and preclinical studies

Shinohara, M., Tachibana, M., Kanekiyo, T. & Bu, G., Jan 1 2017, In : Journal of Lipid Research. 58, 7, p. 1267-1281 15 p.

Research output: Contribution to journalReview article

42 Scopus citations

Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia

International FTD-Genomics Consortium (IFGC), May 1 2017, In : Acta neuropathologica. 133, 5, p. 825-837 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Small molecule inhibitors of mesotrypsin from a structurebased docking screen

Kayode, O., Huang, Z., Soares, A. S., Caulfield, T. R., Dong, Z., Bode, A. M. & Radisky, E. S., May 2017, In : PloS one. 12, 5, e0176694.

Research output: Contribution to journalArticle

2 Scopus citations

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C. C., Zhang, Y. W., Fryer, J. D., Xu, H. & Bu, G., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 597-607 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

Schludi, M. H., Becker, L., Garrett, L., Gendron, T. F., Zhou, Q., Schreiber, F., Popper, B., Dimou, L., Strom, T. M., Winkelmann, J., von Thaden, A., Rentzsch, K., May, S., Michaelsen, M., Schwenk, B. M., Tan, J., Schoser, B., Dieterich, M., Petrucelli, L., Hölter, S. M. & 7 others, Wurst, W., Fuchs, H., Gailus-Durner, V., de Angelis, M. H., Klopstock, T., Arzberger, T. & Edbauer, D., Aug 1 2017, In : Acta neuropathologica. 134, 2, p. 241-254 14 p.

Research output: Contribution to journalArticle

36 Scopus citations

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS

Taskesen, E., Mishra, A., van der Sluis, S., Ferrari, R., Veldink, J. H., van Es, M. A., Smit, A. B., Posthuma, D., Pijnenburg, Y., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Schofield, P. R., Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L. & 142 others, Thompson, E., Haan, E., Hernández, I., Ruiz, A., Boada, M., Borroni, B., Padovani, A., Cruchaga, C., Cairns, N. J., Benussi, L., Binetti, G., Ghidoni, R., Forloni, G., Albani, D., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Clarimón, J., Lleó, A., Blesa, R., Waldö, M. L., Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G. Y. R., Mann, D. M. A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., McKeith, I. G., Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Pastor, P., Razquin, C., Ortega-Cubero, S., Alonso, E., Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M., Uphill, J., Collinge, J., Mead, S., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., van der Zee, J., Van Broeckhoven, C., Cappa, S. F., Leber, I., Hannequin, D., Golfier, V., Vercelletto, M., Brice, A., Nacmias, B., Sorbi, S., Bagnoli, S., Piaceri, I., Nielsen, J. E., Hjermind, L. E., Riemenschneider, M., Mayhaus, M., Ibach, B., Gasparoni, G., Pichler, S., Gu, W., Rossor, M. N., Fox, N. C., Warren, J. D., Spillantini, M. G., Morris, H. R., Rizzu, P., Heutink, P., Snowden, J. S., Rollinson, S., Richardson, A., Gerhard, A., Bruni, A. C., Maletta, R., Frangipane, F., Cupidi, C., Bernardi, L., Anfossi, M., Gallo, M., Conidi, M. E., Smirne, N., Rademakers, R., Baker, M., Dickson, D. W., Graff-Radford, N. R., Petersen, R. C., Knopman, D., Josephs, K. A., Boeve, B. F., Parisi, J. E., Seeley, W. W., Miller, B. L., Karydas, A. M., Rosen, H., van Swieten, J. C., Dopper, E. G. P., Seelaar, H., Scheltens, P., Logroscino, G., Capozzo, R., Novelli, V., Puca, A. A., Franceschi, M., Postiglione, A., Milan, G., Sorrentino, P., Kristiansen, M., Chiang, H. H., Graff, C., Pasquier, F., Rollin, A., Deramecourt, V., Lebouvier, T., Kapogiannis, D., Ferrucci, L., Pickering-Brown, S., Singleton, A. B., Hardy, J. & Momeni, P., Dec 1 2017, In : Scientific reports. 7, 1, 8899.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer’s disease

Li, Y., Chen, Z., Gao, Y., Pan, G., Zheng, H., Zhang, Y., Xu, H., Bu, G. D. & Zheng, H., Sep 20 2017, In : Journal of Neuroscience. 37, 38, p. 9259-9268 10 p.

Research output: Contribution to journalArticle

8 Scopus citations