Research Output

2017

Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments

Mukherjee, S., Russell, J. C., Carr, D. T., Burgess, J. D., Allen, M., Serie, D. J., Boehme, K. L., Kauwe, J. S. K., Naj, A. C., Fardo, D. W., Dickson, D. W., Montine, T. J., Ertekin-Taner, N., Kaeberlein, M. R. & Crane, P. K., Oct 2017, In : Alzheimer's and Dementia. 13, 10, p. 1133-1142 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
57 Scopus citations

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Moujalled, D., Grubman, A., Acevedo, K., Yang, S., Ke, Y. D., Moujalled, D. M., Duncan, C., Caragounis, A., Perera, N. D., Turner, B. J., Prudencio, M., Petrucelli, L., Blair, I., Ittner, L. M., Crouch, P. J., Liddell, J. R. & White, A. R., May 1 2017, In : Human Molecular Genetics. 26, 9, p. 1732-1746 15 p., ddx093.

Research output: Contribution to journalArticle

18 Scopus citations

The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion

von Einem, B., Eschbach, J., Kiechle, M., Wahler, A., Thal, D. R., McLean, P. J., Weishaupt, J. H., Ludolph, A. C., von Arnim, C. A. F. & Danzer, K. M., Jul 1 2017, In : Aging. 9, 7, p. 1677-1697 21 p.

Research output: Contribution to journalArticle

5 Scopus citations

The lysosomal protein cathepsin L is a progranulin protease

Lee, C. W., Stankowski, J. N., Chew, J., Cook, C. N., Lam, Y. W., Almeida, S., Carlomagno, Y., Lau, K. F., Prudencio, M., Gao, F. B., Bogyo, M., Dickson, D. W. & Petrucelli, L., Jul 25 2017, In : Molecular neurodegeneration. 12, 1, 55.

Research output: Contribution to journalArticle

17 Scopus citations

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Ando, M., Fiesel, F. C., Hudec, R., Caulfield, T. R., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V. L., Dawson, T. M., Bu, G., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In : Molecular neurodegeneration. 12, 1, 32.

Research output: Contribution to journalArticle

19 Scopus citations

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

Mackenzie, I. R., Nicholson, A. M., Sarkar, M., Messing, J., Purice, M. D., Pottier, C., Annu, K., Baker, M., Perkerson, R. B., Kurti, A., Matchett, B. J., Mittag, T., Temirov, J., Hsiung, G. Y. R., Krieger, C., Murray, M. E., Kato, M., Fryer, J. D., Petrucelli, L., Zinman, L. & 22 others, Weintraub, S., Mesulam, M., Keith, J., Zivkovic, S. A., Hirsch-Reinshagen, V., Roos, R. P., Züchner, S., Graff-Radford, N. R., Petersen, R. C., Caselli, R. J., Wszolek, Z. K., Finger, E., Lippa, C., Lacomis, D., Stewart, H., Dickson, D. W., Kim, H. J., Rogaeva, E., Bigio, E., Boylan, K. B., Taylor, J. P. & Rademakers, R., Aug 16 2017, In : Neuron. 95, 4, p. 808-816.e9

Research output: Contribution to journalArticle

182 Scopus citations

TMEM106B and myelination: Rare leukodystrophy families reveal unexpected connections

Zhou, X. & Rademakers, R. V., Dec 1 2017, In : Brain. 140, 12, p. 3069-3072 4 p.

Research output: Contribution to journalArticle

Transethnic genome-wide scan identifies novel Alzheimer's disease loci

Alzheimer's Disease Genetics Consortium, Jul 2017, In : Alzheimer's and Dementia. 13, 7, p. 727-738 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

TREM2/DAP12 complex regulates inflammatory responses in Microglia via the JNK signaling pathway

Zhong, L., Zhang, Z. L., Li, X., Liao, C., Mou, P., Wang, T., Wang, Z., Wang, Z., Wei, M., Xu, H., Bu, G. & Chen, X. F., Jun 21 2017, In : Frontiers in Aging Neuroscience. 9, JUN, 204.

Research output: Contribution to journalArticle

18 Scopus citations

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Zheng, H., Jia, L., Liu, C-C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H. & Bu, G. D., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1772-1784 13 p.

Research output: Contribution to journalArticle

70 Scopus citations

Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans

Alzheimer's Disease Genetics Consortium, Feb 1 2017, In : Alzheimer's and Dementia. 13, 2, p. 119-129 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Unlocking the Mystery of ALS

Petrucelli, L. & Gitler, A. D., May 16 2017, In : Scientific American. 316, 6, p. 46-51 6 p.

Research output: Contribution to journalArticle

Uptake of AV-1451 in meningiomas

Bruinsma, T. J., Johnson, D. R., Fang, P., Senjem, M., Josephs, K. A., Whitwell, J. L., Boeve, B. F., Pandey, M. K., Kantarci, K., Jones, D. T., Vemuri, P., Murray, M., Graff-Radford, J., Schwarz, C. G., Knopman, D. S., Petersen, R. C., Jack, C. R. & Lowe, V. J., Dec 1 2017, In : Annals of Nuclear Medicine. 31, 10, p. 736-743 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
19 Scopus citations

White-matter integrity on DTI and the pathologic staging of Alzheimer's disease

Kantarci, K. M., Murray, M. E., Schwarz, C., Reid, R. I., Przybelski, S. A., Lesnick, T., Zuk, S. M., Raman, M. R., Senjem, M. L., Gunter, J. L., Boeve, B. F., Knopman, D. S., Parisi, J. E., Petersen, R. C., Jack, C. R. J. & Dickson, D. W., Aug 1 2017, In : Neurobiology of Aging. 56, p. 172-179 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; The Atherosclerosis Risk in Communities-Neurocognitive Study

Simino, J., Wang, Z., Bressler, J., Chouraki, V., Yang, Q., Younkin, S. G., Seshadri, S., Fornage, M., Boerwinkle, E. & Mosley, T. H., Jul 2017, In : PloS one. 12, 7, e0180046.

Research output: Contribution to journalArticle

1 Scopus citations

α-synuclein astrogliopathy: A possible specific feature in α-synucleinopathy

Koga, S., Kasanuki, K. & Dickson, D. W., 2017, (Accepted/In press) In : Neuropathology.

Research output: Contribution to journalArticle

3 Scopus citations
2016

[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration

Josephs, K. A., Whitwell, J. L., Tacik, P., Duffy, J. R., Senjem, M. L., Tosakulwong, N., Jack, C. R. J., Lowe, V., Dickson, D. W. & Murray, M. E., Sep 19 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-3 3 p.

Research output: Contribution to journalArticle

69 Scopus citations

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

ABCA7 loss-of-function variants, expression, and neurologic disease risk

Allen, M., Lincoln, S. J., Corda, M., Watzlawik, J. O., Carrasquillo, M. M., Reddy, J. S., Burgess, J. D., Nguyen, T., Malphrus, K., Petersen, R. C., Graff Radford, N. R., Dickson, D. W. & Taner, N., Jan 1 2016, In : Neurology: Genetics. 3, 1, e126.

Research output: Contribution to journalArticle

13 Scopus citations

Adult-onset cerebello-brainstem dominant form of X-linked adrenoleukodystrophy presenting as multiple system atrophy: Case report and literature review

Ogaki, K., Koga, S., Aoki, N., Lin, W., Suzuki, K., Ross, O. A. & Dickson, D. W., Feb 1 2016, In : Neuropathology. 36, 1, p. 64-76 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

A genome-wide association study in multiple system atrophy

On behalf of the European Multiple System Atrophy Study Group & the UK Multiple System Atrophy Study Group, Oct 11 2016, In : Neurology. 87, 15, p. 1591-1598 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., Halliday, G. M., Ironside, J. W., Love, S., Mackenzie, I. R., Munoz, D. G., Murray, M. E., Nelson, P. T., Takahashi, H., Trojanowski, J. Q., Ansorge, O. & 52 others, Arzberger, T., Baborie, A., Beach, T. G., Bieniek, K. F., Bigio, E. H., Bodi, I., Dugger, B. N., Feany, M., Gelpi, E., Gentleman, S. M., Giaccone, G., Hatanpaa, K. J., Heale, R., Hof, P. R., Hofer, M., Hortobágyi, T., Jellinger, K., Jicha, G. A., Ince, P., Kofler, J., Kövari, E., Kril, J. J., Mann, D. M., Matej, R., McKee, A. C., McLean, C., Milenkovic, I., Montine, T. J., Murayama, S., Lee, E. B., Rahimi, J., Rodriguez, R. D., Rozemüller, A., Schneider, J. A., Schultz, C., Seeley, W., Seilhean, D., Smith, C., Tagliavini, F., Takao, M., Thal, D. R., Toledo, J. B., Tolnay, M., Troncoso, J. C., Vinters, H. V., Weis, S., Wharton, S. B., White, C. L., Wisniewski, T., Woulfe, J. M., Yamada, M. & Dickson, D. W., Jan 1 2016, In : Acta neuropathologica. 131, 1, p. 87-102 16 p.

Research output: Contribution to journalArticle

165 Scopus citations

A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

Preininger, M. K., Jha, R., Maxwell, J. T., Wu, Q., Singh, M., Wang, B., Dalal, A., McEachin, Z. T., Rossoll, W., Hales, C. M., Fischbach, P. S., Wagner, M. B. & Xu, C., Sep 1 2016, In : DMM Disease Models and Mechanisms. 9, 9, p. 927-939 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

A large-scale comparison of cortical thickness and volume methods for measuring Alzheimer's disease severity

Schwarz, C. G., Gunter, J. L., Wiste, H. J., Przybelski, S. A., Weigand, S. D., Ward, C. P., Senjem, M. L., Vemuri, P., Murray, M. E., Dickson, D. W., Parisi, J. E., Kantarci, K., Weiner, M. W., Petersen, R. C. & Jack, C. R., 2016, In : NeuroImage: Clinical. 11, p. 802-812 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

ALS and FTD: an epigenetic perspective

Belzil, V., Katzman, R. B. & Petrucelli, L., Jun 9 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journalArticle

36 Scopus citations

Alzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci

Alzheimer's Disease Genetics Consortium (ADGC), Feb 2016, In : PloS one. 11, 2, e0148717.

Research output: Contribution to journalArticle

35 Scopus citations

A mercaptoacetamide-based Class II histone deacetylase inhibitor increases dendritic spine density via RasGRF1/ERK pathway

Song, J. M., Sung, Y. M., Nam, J. H., Yoon, H., Chung, A., Moffat, E., Jung, M., Pak, D. T. S., Kim, J. & Hoe, H. S., Mar 15 2016, In : Journal of Alzheimer's Disease. 51, 2, p. 591-604 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

An acrobatic substrate metamorphosis reveals a requirement for substrate conformational dynamics in trypsin proteolysis

Kayode, O., Wang, R., Pendlebury, D. F., Cohen, I., Henin, R. D., Hockla, A., Soares, A. S., Papo, N., Caulfield, T. R. & Radisky, E. S., Dec 16 2016, In : Journal of Biological Chemistry. 291, 51, p. 26304-26319 16 p.

Research output: Contribution to journalArticle

11 Scopus citations
195 Scopus citations

A neurotensin analog blocks cocaine-conditioned place preference and reinstatement

Boules, M., Netz, R., Fredrickson, P. A. & Richelson, E., Apr 2016, In : Behavioural Pharmacology. 27, 2-3, p. 236-239 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer's disease

Sarro, L., Tosakulwong, N., Schwarz, C., Graff-Radford, J., Przybelski, S. A., Lesnick, T. G., Zuk, S. M., Reid, R. I., Raman, M. R., Boeve, B. F., Ferman, T. J., Knopman, D. S., Comi, G., Filippi, M., Murray, M. E., Parisi, J. E., Dickson, D. W., Petersen, R. C., Jack, C. R. J. & Kantarci, K. M., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

15 Scopus citations
2 Scopus citations

A novel Alzheimer disease locus located near the gene encoding tau protein

Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J. C., Chung, J., Naj, A. C., Kunkle, B. W., Wang, L. S., Bis, J. C., Bellenguez, C., Harold, D., Lunetta, K. L., Destefano, A. L., Grenier-Boley, B., Sims, R., Beecham, G. W., Smith, A. V., Chouraki, V., Hamilton-Nelson, K. L., Ikram, M. A. & 332 others, Fievet, N., Denning, N., Martin, E. R., Schmidt, H., Kamatani, Y., Dunstan, M. L., Valladares, O., Laza, A. R., Zelenika, D., Ramirez, A., Foroud, T. M., Choi, S. H., Boland, A., Becker, T., Kukull, W. A., Van Der Lee, S. J., Pasquier, F., Cruchaga, C., Beekly, D., Fitzpatrick, A. L., Hanon, O., Gill, M., Barber, R., Gudnason, V., Campion, D., Love, S., Bennett, D. A., Amin, N., Berr, C., Tsolaki, M., Buxbaum, J. D., Lopez, O. L., Deramecourt, V., Fox, N. C., Cantwell, L. B., Tárraga, L., Dufouil, C., Hardy, J., Crane, P. K., Eiriksdottir, G., Hannequin, D., Clarke, R., Evans, D., Mosley, T. H., Letenneur, L., Brayne, C., Maier, W., De Jager, P., Emilsson, V., Dartigues, J. F., Hampel, H., Kamboh, M. I., De Bruijn, R. F. A. G., Tzourio, C., Pastor, P., Larson, E. B., Rotter, J. I., O'Donovan, M. C., Montine, T. J., Nalls, M. A., Mead, S., Reiman, E. M., Jonsson, P. V., Holmes, C., St George-Hyslop, P. H., Boada, M., Passmore, P., Wendland, J. R., Schmidt, R., Morgan, K., Winslow, A. R., Powell, J. F., Carasquillo, M., Younkin, S. G., Jakobsdóttir, J., Kauwe, J. S. K., Wilhelmsen, K. C., Rujescu, D., Nöthen, M. M., Hofman, A., Jones, L., Haines, J. L., Psaty, B. M., Van Broeckhoven, C., Holmans, P., Launer, L. J., Mayeux, R., Lathrop, M., Goate, A. M., Escott-Price, V., Seshadri, S., Pericak-Vance, M. A., Amouyel, P., Williams, J., Van Duijn, C. M., Schellenberg, G. D., Farrer, L. A., Adams, P. M., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Asthana, S., Atwood, C. S., Baldwin, C. T., Barmada, M. M., Barnes, L. L., Beach, T. G., Bigio, E. H., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Cairns, N. J., Cao, C., Carlson, C. S., Carlsson, C. M., Carney, R. M., Carrasquillo, M. M., Carroll, S. L., Chui, H. C., Clark, D. G., Corneveaux, J., Cribbs, D. H., Crocco, E. A., DeCarli, C., DeKosky, S. T., Yesim Demirci, F., Dick, M., Dickson, D. W., Doody, R. S., Duara, R., Ertekin-Taner, N., Faber, K. M., Fairchild, T. J., Fallon, K. B., Farlow, M. R., Ferris, S., Frosch, M. P., Galasko, D. R., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Glass, J. D., Graff-Radford, N. R., Green, R. C., Growdon, J. H., Hakonarson, H., Hamilton, R. L., Harrell, L. E., Head, E., Honig, L. S., Huebinger, R. M., Huentelman, M. J., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Jicha, G. A., Jin, L. W., Karydas, A., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., LaFerla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lin, C. F., Lyketsos, C. G., Mack, W. J., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Morris, J. C., Mukherjee, S., Murrell, J. R., Myers, A. J., O'Bryant, S., Olichney, J. M., Pankratz, V. S., Parisi, J. E., Partch, A., Paulson, H. L., Perry, W., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reisberg, B., Reisch, J. S., Reitz, C., Ringman, J. M., Roberson, E. D., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Royall, D. R., Sager, M. A., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Tsuang, D. W., Van Deerlin, V. M., Van Eldik, L. J., Vardarajan, B. N., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Wishnek, S., Woltjer, R. L., Wright, C. B., Wu, C. K., Yu, C. E., Yu, L., Thomas, C., Gerrish, A., Chapman, J., Stretton, A., Morgan, A., Oldham, H., Owen, M. J., Kehoe, P. G., Medway, C., Brown, K., Lord, J., Turton, J., Hooper, N. M., Vardy, E., Warren, J. D., Schott, J. M., Uphill, J., Hollingworth, P., Ryan, N., Rossor, M., Collinge, J., Ben-Shlomo, Y., Makrina, D., Gkatzima, O., Lupton, M., Koutroumani, M., Avramidou, D., Germanou, A., Jessen, F., Riedel-Heller, S., Dichgans, M., Heun, R., Kölsch, H., Schürmann, B., Herold, C., Lacour, A., Drichel, D., Hoffmann, P., Kornhuber, J., Gu, W., Feulner, T., Mayhaus, M., Pichler, S., Riemenschneider, M., van den Bussche, H., Lawlor, B., Lynch, A., Mann, D., Smith, A. D., Warden, D., Wilcock, G., Heuser, I., Wiltfang, J., Frölich, L., Hüll, M., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Russo, G., Jöckel, K. H., Moebus, S., Klopp, N., Wichmann, H. E., Ma, L., Bisceglio, G., Fisher, E., Warner, N., Pickering-Brown, S., Craig, D., Johnston, J. A., McGuinness, B., Todd, S., Rubinsztein, D. C., Lovestone, S., Bayer, A., Gallacher, J., Proitsi, P. & Ortega-Cubero, S., Jan 1 2016, In : Molecular Psychiatry. 21, 1, p. 108-117 10 p.

Research output: Contribution to journalArticle

89 Scopus citations

A novel ANO3 variant identified in a 53-year-old woman presenting with hyperkinetic dysarthria, blepharospasm, hyperkinesias, and complex motor tics

Blackburn, P. R., Zimmermann, M. T., Gass, J. M., Harris, K. G., Cousin, M. A., Boczek, N. J., Ross, O. A., Klee, E. W., Brazis, P. W., Van Gerpen, J. A. & Atwal, P. S., Dec 5 2016, In : BMC Medical Genetics. 17, 1, 93.

Research output: Contribution to journalArticle

5 Scopus citations

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G. D., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

36 Scopus citations

Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer's Disease

Kanekiyo, T. & Bu, G. D., 2016, Genes, Environment and Alzheimer's Disease. Elsevier Inc., p. 171-196 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Yamazaki, Y., Painter, M. M., Bu, G. D. & Kanekiyo, T., Jun 21 2016, (Accepted/In press) In : CNS Drugs. p. 1-17 17 p.

Research output: Contribution to journalArticle

36 Scopus citations

Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population

Kang, R., Li, P., Wang, T., Li, X., Wei, Z., Zhang, Z., Zhong, L., Cao, L., Heckman, M. G., Zhang, Y. W., Xu, H., Huang, C., Bu, G. D. & Chen, X. F., Jan 28 2016, In : Scientific Reports. 6, 19930.

Research output: Contribution to journalArticle

11 Scopus citations

Apolipoprotein e lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Fu, Y., Zhao, J., Atagi, Y., Nielsen, H. M., Liu, C. C., Zheng, H., Shinohara, M., Kanekiyo, T. & Bu, G., May 5 2016, In : Molecular neurodegeneration. 11, 1, 99.

Research output: Contribution to journalArticle

23 Scopus citations

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology

Zhang, C., Shi, Z., Zhang, L., Zhou, Z., Zheng, X., Liu, G., Bu, G., Fraser, P. E., Xu, H. & Zhang, Y. W., 2016, In : Journal of cell science. 129, 5, p. 994-1002 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

A rapid, semi-quantitative assay to screen for modulators of Alpha-synuclein oligomerization ex vivo

Delenclos, M., Trendafilova, T., Jones, D. R., Moussaud, S., Baine, A. M., Yue, M., Hirst, W. D. & McLean, P. J., 2016, In : Frontiers in Neuroscience. 9, JAN, 511.

Research output: Contribution to journalArticle

3 Scopus citations

A rapid and cost-effective method for genotyping apolipoprotein e gene polymorphism

Zhong, L., Xie, Y. Z., Cao, T. T., Wang, Z., Wang, T., Li, X., Shen, R. C., Xu, H., Bu, G. & Chen, X. F., Jan 12 2016, In : Molecular neurodegeneration. 11, 1, 2.

Research output: Contribution to journalArticle

18 Scopus citations

Arguing against the proposed definition changes of PD

Boeve, B. F., Dickson, D. W., Duda, J. E., Ferman, T. J., Galasko, D. R., Galvin, J. E., Goldman, J. G., Growdon, J. H., Hurtig, H. I., Kaufer, D. I., Kantarci, K., Leverenz, J. B., Lippa, C. F., Lopez, O. L., McKeith, I. G., Singleton, A. B., Taylor, A., Tsuang, D., Weintraub, D. & Zabetian, C. P., Nov 1 2016, In : Movement Disorders. 31, 11, p. 1619-1622 4 p.

Research output: Contribution to journalReview article

33 Scopus citations

Assessment of olfactory function in MAPT-associated neurodegenerative disease reveals odor-identification irreproducibility as a non-disease-specific, general characteristic of olfactory dysfunction

Markopoulou, K., Chase, B. A., Robowski, P., Strongosky, A., Narozańska, E., Sitek, E. J., Berdynski, M., Barcikowska, M., Baker, M. C., Rademakers, R., Sławek, J., Klein, C., Hückelheim, K., Kasten, M. & Wszolek, Z. K., Nov 2016, In : PloS one. 11, 11, e0165112.

Research output: Contribution to journalArticle

6 Scopus citations

Assessment of the genetic variance of late-onset Alzheimer's disease

Alzheimer's Disease Genetics Consortium (ADGC), May 1 2016, In : Neurobiology of aging. 41, p. 200.e13-200.e20

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Association of GBA mutations and the E326K polymorphism with motor and cognitive progression in parkinson disease

Davis, M. Y., Johnson, C. O., Leverenz, J. B., Weintraub, D., Trojanowski, J. Q., Chen-Plotkin, A., Van Deerlin, V. M., Quinn, J. F., Chung, K. A., Peterson-Hiller, A. L., Rosenthal, L. S., Dawson, T. M., Albert, M. S., Goldman, J. G., Stebbins, G. T., Bernard, B., Wszolek, Z. K., Ross, O. A., Dickson, D. W., Eidelberg, D. & 10 others, Mattis, P. J., Niethammer, M., Yearout, D., Hu, S. C., Cholerton, B. A., Smith, M., Mata, I. F., Montine, T. J., Edwards, K. L. & Zabetian, C. P., Oct 1 2016, In : JAMA Neurology. 73, 10, p. 1217-1224 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Association of Parkinson disease age of onset with DRD2, DRD3 and GRIN2B polymorphisms

Hassan, A., Heckman, M. G., Ahlskog, J. E., Wszolek, Z. K., Serie, D. J., Uitti, R. J., Van Gerpen, J. A., Okun, M. S., Rayaprolu, S. & Ross, O. A., Jan 1 2016, In : Parkinsonism and Related Disorders. 22, p. 102-105 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Autosomal dominant Parkinson's disease caused by SNCA duplications

Konno, T., Ross, O. A., Puschmann, A., Dickson, D. W. & Wszolek, Z. K., Jan 1 2016, In : Parkinsonism and Related Disorders. 22, p. S1-S6

Research output: Contribution to journalArticle

59 Scopus citations