Research Output 1976 2020

2020
1 Citation (Scopus)

Aberrant Accumulation of BRCA1 in Alzheimer Disease and Other Tauopathies

Nakamura, M., Kaneko, S., Dickson, D. W. & Kusaka, H., Jan 1 2020, In : Journal of Neuropathology and Experimental Neurology. 79, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

Tauopathies
Alzheimer Disease
Pick Disease of the Brain
DNA Damage
Progressive Supranuclear Palsy

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Park, J. H., Burgess, J. D., Faroqi, A. H., Demeo, N. N., Fiesel, F. C., Springer, W., Delenclos, M. & McLean, P. J., Jan 13 2020, In : Molecular neurodegeneration. 15, 1, 5.

Research output: Contribution to journalArticle

Open Access
Sirtuin 3
alpha-Synuclein
Synucleins
Parkinson Disease
Mitochondrial Dynamics

ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components

Yamazaki, Y., Shinohara, M., Yamazaki, A., Ren, Y., Asmann, Y. W., Kanekiyo, T. & Bu, G., Jan 1 2020, In : Arteriosclerosis, thrombosis, and vascular biology. 40, 1, p. 128-144 17 p.

Research output: Contribution to journalArticle

Open Access
Apolipoprotein E4
Pericytes
Apolipoproteins E
Basement Membrane
Protein Isoforms
4 Citations (Scopus)

Association between contact sports participation and chronic traumatic encephalopathy: a retrospective cohort study

Bieniek, K. F., Blessing, M. M., Heckman, M. G., Diehl, N. N., Serie, A. M., Paolini, M. A., Boeve, B. F., Savica, R., Reichard, R. R. & Dickson, D. W., Jan 1 2020, In : Brain Pathology. 30, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Open Access
Sports
Cohort Studies
Retrospective Studies
Pathology
Athletes

Aβ Puts the Alpha in Synuclein

Cook, C. & Petrucelli, L., Jan 22 2020, In : Neuron. 105, 2, p. 205-206 2 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Synucleins
Pathology
Neurodegenerative Diseases
Parkinson Disease

Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants

Whitwell, J. L., Tosakulwong, N., Botha, H., Ali, F., Clark, H. M., Duffy, J. R., Utianski, R. L., Stevens, C. A., Weigand, S. D., Schwarz, C. G., Senjem, M. L., Jack, C. R., Lowe, V. J., Ahlskog, J. E., Dickson, D. W. & Josephs, K. A., 2020, In : NeuroImage: Clinical. 25, 102152.

Research output: Contribution to journalArticle

Open Access
Progressive Supranuclear Palsy
Brain
Subthalamic Nucleus
Globus Pallidus
Motor Cortex

Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes

Vu, L., An, J., Kovalik, T., Gendron, T., Petrucelli, L. & Bowser, R., Jan 1 2020, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry. 321916.

Research output: Contribution to journalArticle

Open Access
Chitinases
Amyotrophic Lateral Sclerosis
Astrocytes
Cerebrospinal Fluid
Proteins

Functional Analysis of the SIM1 Variant p.G715V in 2 Patients With Obesity

Blackburn, P. R., Sullivan, A. E., Gerassimou, A. G., Kleinendorst, L., Bersten, D. C., Cooiman, M., Harris, K. G., Wierenga, K. J., Klee, E. W., van Gerpen, J. A., Ross, O. A., van Haelst, M. M., Whitelaw, M. L., Caulfield, T. R. & Atwal, P. S., Jan 1 2020, In : The Journal of clinical endocrinology and metabolism. 105, 1

Research output: Contribution to journalArticle

Functional analysis
Intellectual Disability
Obesity
Doxycycline
Body Mass Index

Molecular inhibitor of QSOX1 suppresses tumor growth in vivo

Fifield, A. L., Hanavan, P. D., Faigel, D. O., Sergienko, E., Bobkov, A., Meurice, N., Petit, J. L., Polito, A., Caulfield, T. R., Castle, E. P., Copland, J. A., Mukhopadhyay, D., Pal, K., Dutta, S. K., Luo, H., Ho, T. H. & Lake, D. F., Jan 1 2020, In : Molecular cancer therapeutics. 19, 1, p. 112-122 11 p.

Research output: Contribution to journalArticle

Growth
Neoplasms
sulfhydryl oxidase
Enzyme Assays
Renal Cell Carcinoma

Trajectory of lobar atrophy in asymptomatic and symptomatic GRN mutation carriers: a longitudinal MRI study

Chen, Q., Boeve, B. F., Senjem, M., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J., Forsberg, L., Gavrilova, R., Gearhart, D., Graff-Radford, J., Graff-Radford, N., Jack, C. R., Jones, D., Knopman, D., Kremers, W. K., Lapid, M., Rademakers, R., Ramos, E. M. & 5 others, Syrjanen, J., Boxer, A. L., Rosen, H., Wszolek, Z. K. & Kantarci, K., Jan 1 2020, (Accepted/In press) In : Neurobiology of aging.

Research output: Contribution to journalArticle

Atrophy
Longitudinal Studies
Mutation
Temporal Lobe
Frontotemporal Lobar Degeneration
2019
2 Citations (Scopus)

4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration

Saijo, E., Metrick, M. A., Koga, S., Parchi, P., Litvan, I., Spina, S., Boxer, A., Rojas, J. C., Galasko, D., Kraus, A., Rossi, M., Newell, K., Zanusso, G., Grinberg, L. T., Seeley, W. W., Ghetti, B., Dickson, D. W. & Caughey, B., Jan 1 2019, (Accepted/In press) In : Acta neuropathologica.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Tauopathies
Progressive Supranuclear Palsy
Cerebrospinal Fluid
Seeds

5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway

Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C-C., Kanekiyo, T. & Bu, G. D., Mar 2 2019, In : International Journal of Molecular Sciences. 20, 6, 1488.

Research output: Contribution to journalArticle

Open Access
Serotonin 5-HT3 Receptor Antagonists
Ondansetron
secretions
Apolipoproteins E
liver

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

Aikawa, T., Ren, Y., Yamazaki, Y., Tachibana, M., Johnson, M. R., Anderson, C. T., Martens, Y. A., Holm, M. L., Asmann, Y. W., Saito, T., Saido, T. C., Fitzgerald, M. L., Bu, G. & Kanekiyo, T., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23790-23796 7 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Amyloid
Brain
Nonsense Codon
Microglia
10 Citations (Scopus)

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Chew, J., Cook, C., Gendron, T. D., Jansen-West, K., Del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., Fryer, J. D., Zhang, Y. & Petrucelli, L., Feb 15 2019, In : Molecular neurodegeneration. 14, 1, 1 p.

Research output: Contribution to journalArticle

TDP-43 Proteinopathies
Dipeptides
RNA
Proteins
Antisense RNA

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II

Zhao, S., Li, Z., Zhang, M., Zhang, L., Zheng, H., Ning, J., Wang, Y., Wang, F., Zhang, X., Gan, H., Wang, Y., Zhang, X., Luo, H., Bu, G. D., Xu, H., Yao, Y. & Zhang, Y. W., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 84.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Brain
Mutation
Electroencephalography
Neurons
2 Citations (Scopus)

A comprehensive screening of copy number variability in dementia with Lewy bodies

Kun-Rodrigues, C., Orme, T., Carmona, S., Hernandez, D. G., Ross, O. A., Eicher, J. D., Shepherd, C., Parkkinen, L., Darwent, L., Heckman, M. G., Scholz, S. W., Troncoso, J. C., Pletnikova, O., Dawson, T., Rosenthal, L., Ansorge, O., Clarimon, J., Lleo, A., Morenas-Rodriguez, E., Clark, L. & 48 others, Honig, L. S., Marder, K., Lemstra, A., Rogaeva, E., St. George-Hyslop, P., Londos, E., Zetterberg, H., Barber, I., Braae, A., Brown, K., Morgan, K., Troakes, C., Al-Sarraj, S., Lashley, T., Holton, J., Compta, Y., Van Deerlin, V., Serrano, G. E., Beach, T. G., Lesage, S., Galasko, D., Masliah, E., Santana, I., Pastor, P., Diez-Fairen, M., Aguilar, M., Tienari, P. J., Myllykangas, L., Oinas, M., Revesz, T., Lees, A., Boeve, B. F., Petersen, R. C., Ferman, T. J., Escott-Price, V., Graff Radford, N. R., Cairns, N. J., Morris, J. C., Pickering-Brown, S., Mann, D., Halliday, G. M., Hardy, J., Trojanowski, J. Q., Dickson, D. W., Singleton, A., Stone, D. J., Guerreiro, R. & Bras, J., Mar 1 2019, In : Neurobiology of Aging. 75, p. 223.e1-223.e10

Research output: Contribution to journalArticle

Lewy Body Disease
Genome
Neurodegenerative Diseases
Genes
Dementia
7 Citations (Scopus)

ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD

Moore, S., Alsop, E., Lorenzini, I., Starr, A., Rabichow, B. E., Mendez, E., Levy, J. L., Burciu, C., Reiman, R., Chew, J., Belzil, V., W. Dickson, D., Robertson, J., Staats, K. A., Ichida, J. K., Petrucelli, L., Van Keuren-Jensen, K. & Sattler, R., Jan 1 2019, In : Acta neuropathologica.

Research output: Contribution to journalArticle

RNA Editing
Adenosine Deaminase
RNA
Amyotrophic Lateral Sclerosis
Eukaryotic Initiation Factor-2
3 Citations (Scopus)

Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease

Luo, S., Kang, S. S., Wang, Z. H., Liu, X., Day, J. X., Wu, Z., Peng, J., Xiang, D., Springer, W. & Ye, K., Sep 11 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 37, p. 7291-7305 15 p.

Research output: Contribution to journalArticle

Parkinson Disease
Oxidoreductases
Ubiquitin-Protein Ligases
Dopamine
Oxidative Stress
9 Citations (Scopus)

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB) & The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Aug 1 2019, In : Acta neuropathologica. 138, 2, p. 237-250 14 p.

Research output: Contribution to journalArticle

Open Access
Lewy Body Disease
Frontotemporal Dementia
Alzheimer Disease
Mutation
Neurodegenerative Diseases
1 Citation (Scopus)

Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

Bejanin, A., Murray, M. E., Martin, P., Botha, H., Tosakulwong, N., Schwarz, C. G., Senjem, M. L., Chételat, G., Kantarci, K., Jack, C. R., Boeve, B. F., Knopman, D. S., Petersen, R. C., Giannini, C., Parisi, J. E., Dickson, D. W., Whitwell, J. L. & Josephs, K. A., Nov 1 2019, In : Brain : a journal of neurology. 142, 11, p. 3621-3635 15 p.

Research output: Contribution to journalArticle

Temporal Lobe
Pathology
Alzheimer Disease
Frontotemporal Lobar Degeneration
Lewy Bodies

ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles

Dos Santos Rodrigues, B., Kanekiyo, T. & Singh, J., Sep 16 2019, In : Pharmaceutical research. 36, 11, 1 p.

Research output: Contribution to journalArticle

Gene therapy
Apolipoproteins E
Transferrin
Liposomes
Genetic Therapy
5 Citations (Scopus)

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Tachibana, M., Holm, M. L., Liu, C-C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. D. & Kanekiyo, T., Mar 1 2019, In : Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

Research output: Contribution to journalArticle

LDL Receptors
Amyloid
Apolipoprotein E4
Pathology
Alzheimer Disease
8 Citations (Scopus)

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yamazaki, Y., Zhao, N., Caulfield, T., Liu, C-C. & Bu, G. D., Sep 1 2019, In : Nature Reviews Neurology. 15, 9, p. 501-518 18 p.

Research output: Contribution to journalReview article

Apolipoproteins E
Alzheimer Disease
Apolipoprotein E4
Alleles
Pathology
Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Executive Function
Dementia
Clinical Trials
1 Citation (Scopus)

Association of MAPT H1 subhaplotypes with neuropathology of lewy body disease

Heckman, M. G., Kasanuki, K., Brennan, R. R., Labbé, C., Vargas, E. R., Soto, A. I., Murray, M. E., Koga, S., Dickson, D. W. & Ross, O. A., Jan 1 2019, In : Movement Disorders.

Research output: Contribution to journalArticle

Lewy Body Disease
Microtubule-Associated Proteins
Haplotypes
Tyrosine 3-Monooxygenase
Lewy Bodies
6 Citations (Scopus)

Association of MAPT Subhaplotypes with Risk of Progressive Supranuclear Palsy and Severity of Tau Pathology

Heckman, M. G., Brennan, R. R., Labbé, C., Soto, A. I., Koga, S., Deture, M., Murray, M. E., Petersen, R. C., Boeve, B. F., Van Gerpen, J. A., Uitti, R. J., Wszolek, Z. K., Rademakers, R. V., Dickson, D. W. & Ross, O. A., Jan 1 2019, In : JAMA neurology.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Microtubule-Associated Proteins
Pathology
Haplotypes
Odds Ratio
1 Citation (Scopus)

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model (Nature Communications, (2019), 10, 1, (1365), 10.1038/s41467-019-09118-9)

Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., Chen, K., Wang, N., Zhu, L., Can, D., Marten, Y., Shinohara, M., Liu, C-C., Du, D., Sun, H., Wen, L. & 3 others, Xu, H., Bu, G. D. & Chen, X. F., Dec 1 2019, In : Nature communications. 10, 1, 2923.

Research output: Contribution to journalComment/debate

Open Access
document markup languages
phenotype
HTML
Alzheimer Disease
communication
3 Citations (Scopus)
Tauopathies
DNA-Binding Proteins
Atrophy
Brain
Amygdala

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

Chen, Q., Boeve, B. F., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J. A., Forsberg, L., Gavrilova, R. M., Gearhart, D., Haley, D., Gunter, J. L., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff Radford, N. R., Kraft, R., Lapid, M. I., Rademakers, R. V., Wszolek, Z. K. & 3 others, Rosen, H., Boxer, A. L. & Kantarci, K. M., Jan 1 2019, In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Magnetic Resonance Spectroscopy
Mutation
Brain
Gyrus Cinguli
1 Citation (Scopus)

C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy

Cali, C. P., Patino, M., Tai, Y. K., Ho, W. Y., McLean, C. A., Morris, C. M., Seeley, W. W., Miller, B. L., Gaig, C., Vonsattel, J. P. G., White, C. L., Roeber, S., Kretzschmar, H., Troncoso, J. C., Troakes, C., Gearing, M., Ghetti, B., Van Deerlin, V. M., Lee, V. M. Y., Trojanowski, J. Q. & 6 others, Mok, K. Y., Ling, H., Dickson, D. W., Schellenberg, G. D., Ling, S. C. & Lee, E. B., Nov 1 2019, In : Acta neuropathologica. 138, 5, p. 795-811 17 p.

Research output: Contribution to journalArticle

Autophagy
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Autopsy
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Cellular models of alpha-synuclein toxicity and aggregation

Delenclos, M., Burgess, J. D., Lamprokostopoulou, A., Outeiro, T. F., Vekrellis, K. & McLean, P. J., Jan 1 2019, In : Journal of neurochemistry. 150, 5, p. 566-576 11 p.

Research output: Contribution to journalReview article

Open Access
Synucleins
alpha-Synuclein
Toxicity
Agglomeration
Neurons
1 Citation (Scopus)

Cerebrovascular pathology presenting as corticobasal syndrome: An autopsy case series of “vascular CBS”

Koga, S., Roemer, S. F., Kasanuki, K. & Dickson, D. W., Nov 2019, In : Parkinsonism and Related Disorders. 68, p. 79-84 6 p.

Research output: Contribution to journalArticle

Blood Vessels
Autopsy
Pathology
Frontal Lobe
Pyramidal Tracts
2 Citations (Scopus)

Clinicopathologic correlations in a family with a TBK1 mutation presenting as primary progressive aphasia and primary lateral sclerosis

Hirsch-Reinshagen, V., Alfaify, O. A., Hsiung, G. Y. R., Pottier, C., Baker, M., Perkerson, R. B., Rademakers, R. V., Briemberg, H., Foti, D. J. & Mackenzie, I. R., Jan 1 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Motor Neuron Disease
Phosphotransferases
Mutation
Motor Neurons
1 Citation (Scopus)

Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome

Sakae, N., Josephs, K. A., Litvan, I., Murray, M. E., Duara, R., Uitti, R. J., Wszolek, Z. K., van Gerpen, J., Graff Radford, N. R. & Dickson, D. W., Sep 1 2019, In : Alzheimer's and Dementia. 15, 9, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Substantia Nigra
Pathology
Extremities
Apraxias
5 Citations (Scopus)

CNS small vessel disease: A clinical review

Cannistraro, R. J., Badi, M., Eidelman, B. H., Dickson, D. W., Middlebrooks, E. H. & Meschia, J. F., Jun 11 2019, In : Neurology. 92, 24, p. 1146-1156 11 p.

Research output: Contribution to journalReview article

Dementia
Cerebral Amyloid Angiopathy
Hypertension
Inborn Genetic Diseases
Diffusion Tensor Imaging

Coexistence of Progressive Supranuclear Palsy with Pontocerebellar Atrophy and Myotonic Dystrophy Type 1

Koga, S., Eric Ahlskog, J., DeTure, M. A., Baker, M., Roemer, S. F., Konno, T., Rademakers, R., Ross, O. A. & Dickson, D. W., Jan 1 2019, In : Journal of Neuropathology and Experimental Neurology. 78, 8, p. 756-762 7 p.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Myotonic Dystrophy
Atrophy
Multiple System Atrophy
Cerebellar Ataxia
1 Citation (Scopus)

Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy

Koller, E. J., Gonzalez De La Cruz, E., Machula, T., Ibanez, K. R., Lin, W. L., Williams, T., Riffe, C. J., Ryu, D., Strang, K. H., Liu, X., Janus, C., Golde, T. E., Dickson, D., Giasson, B. I. & Chakrabarty, P., Oct 1 2019, In : Human molecular genetics. 28, 19, p. 3255-3269 15 p.

Research output: Contribution to journalArticle

Tauopathies
Alzheimer Disease
Frontotemporal Dementia
Pick Disease of the Brain
Pathology

Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD (Acta Neuropathologica, (2019), 138, 1, (49-65), 10.1007/s00401-019-01999-w)

Moore, S., Alsop, E., Lorenzini, I., Starr, A., Rabichow, B. E., Mendez, E., Levy, J. L., Burciu, C., Reiman, R., Chew, J., Belzil, V. V., Dickson, D., Robertson, J., Staats, K. A., Ichida, J. K., Petrucelli, L., Van Keuren-Jensen, K. & Sattler, R., Nov 1 2019, In : Acta neuropathologica. 138, 5, p. 883-884 2 p.

Research output: Contribution to journalComment/debate

Open Access
RNA Editing

Correction to: 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration (Acta Neuropathologica, (2019), 10.1007/s00401-019-02080-2)

Saijo, E., Metrick, M. A., Koga, S., Parchi, P., Litvan, I., Spina, S., Boxer, A., Rojas, J. C., Galasko, D., Kraus, A., Rossi, M., Newell, K., Zanusso, G., Grinberg, L. T., Seeley, W. W., Ghetti, B., Dickson, D. W. & Caughey, B., Jan 1 2019, (Accepted/In press) In : Acta neuropathologica.

Research output: Contribution to journalComment/debate

Open Access
Frontotemporal Lobar Degeneration
Seeds
Biomarkers
Brain

Corrigendum: Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes

Russo, A., Scardigli, R., La Regina, F., Murray, M. E., Romano, N., Dickson, D. W., Wolozin, B., Cattaneo, A. & Ceci, M., Apr 1 2019, In : Human molecular genetics. 28, 7, 1 p.

Research output: Contribution to journalArticle

Open Access
Polyribosomes
Proteins
corrigendum
Open Access
Brain
Alzheimer Disease
Animals
Animal Models
Modulation
8 Citations (Scopus)

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Sun, J., Carlson-Stevermer, J., Das, U., Shen, M., Delenclos, M., Snead, A. M., Koo, S. Y., Wang, L., Qiao, D., Loi, J., Petersen, A. J., Stockton, M., Bhattacharyya, A., Jones, M. V., Zhao, X., McLean, P. J., Sproul, A. A., Saha, K. & Roy, S., Dec 1 2019, In : Nature Communications. 10, 1, 53.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
editing
Amyloid beta-Protein Precursor
Protein C
Amyloid
3 Citations (Scopus)

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V. J., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M. K., Murray, M. E., Kantarci, K., Jones, D. T., Vemuri, P., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

Entorhinal Cortex
Temporal Lobe
Cognition
Amyloid
Brain
3 Citations (Scopus)

Crosstalk of Local Translation and Mitochondria: Powering Plasticity in Axons and Dendrites

Rossol, W. & Bassell, G. J., Jan 16 2019, In : Neuron. 101, 2, p. 204-206 3 p.

Research output: Contribution to journalShort survey

Dendrites
Axons
Mitochondria
Endosomes
Protein Biosynthesis

CSF1R mutation presenting as dementia with Lewy bodies

Sharma, R., Graff-Radford, J., Rademakers, R. V., Boeve, B. F., Petersen, R. C. & Jones, D. T., Jan 1 2019, In : Neurocase.

Research output: Contribution to journalArticle

Lewy Body Disease
Mutation
Colony-Stimulating Factor Receptors
Leukoencephalopathies
Macrophage Colony-Stimulating Factor
Open Access
Frontotemporal Lobar Degeneration
Neurites
Inclusion Bodies
Mutation
Blood Vessels

Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma

Madamsetty, V. S., Pal, K., Dutta, S. K., Wang, E., Thompson, J. R., Banerjee, R. K., Caulfield, T. R., Mody, K., Yen, Y., Mukhopadhyay, D. & Huang, H. S., Oct 16 2019, In : Bioconjugate Chemistry. 30, 10, p. 2703-2713 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
gemcitabine
Adenocarcinoma
Chemotherapy
Protein-Tyrosine Kinases

Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties

Santos Rodrigues, B. D., Lakkadwala, S., Kanekiyo, T. & Singh, J., Jan 1 2019, In : International journal of nanomedicine. 14, p. 6497-6517 21 p.

Research output: Contribution to journalArticle

Open Access
Liposomes
Nanoparticles
Lipids
Brain
Screening
1 Citation (Scopus)

Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer

Madamsetty, V. S., Pal, K., Keshavan, S., Caulfield, T. R., Dutta, S. K., Wang, E., Fadeel, B. & Mukhopadhyay, D., Dec 7 2019, In : Nanoscale. 11, 45, p. 22006-22018 13 p.

Research output: Contribution to journalArticle

Nanodiamonds
irinotecan
Tumors
Curcumin
Drug delivery

Diffuse Lewy Body Disease and Alzheimer Disease: Neuropathologic Phenotype Associated With the PSEN1 p.A396T Mutation

Gondim, D. D., Oblak, A., Murrell, J. R., Richardson, R., Epperson, F., Ross, O. A. & Ghetti, B., Jul 1 2019, In : Journal of neuropathology and experimental neurology. 78, 7, p. 585-594 10 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Body Disease
Alzheimer Disease
Phenotype
Mutation