• 3384 Citations
  • 31 Scopus h-Index
19962019

Research output per year

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Research Output

20 Scopus citations

Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations

Blancas-Mejía, L. M., Tischer, A., Thompson, J. R., Tai, J., Wang, L., Auton, M. & Ramirez-Alvarado, M., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 347-361 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients

Blancas-Mejía, L. M., Martin, E. B., Williams, A., Wall, J. S. & Ramirez-Alvarado, M., 2017, (Accepted/In press) In : Biophysical Chemistry.

Research output: Contribution to journalArticle

2 Scopus citations

Light chain amyloid fibrils cause metabolic dysfunction in human cardiomyocytes

McWilliams-Koeppen, H. P., Foster, J. S., Hackenbrack, N., Ramirez-Alvarado, M., Donohoe, D., Williams, A., Macy, S., Wooliver, C., Wortham, D., Morrell-Falvey, J., Foster, C. M., Kennel, S. J. & Wall, J. S., Sep 22 2015, In : PLoS One. 10, 9, e0137716.

Research output: Contribution to journalArticle

34 Scopus citations

Light chain amyloidosis - Current findings and future prospects

Baden, E. M., Sikkink, L. A. & Ramirez-Alvarado, M., Oct 2 2009, In : Current Protein and Peptide Science. 10, 5, p. 500-508 9 p.

Research output: Contribution to journalReview article

34 Scopus citations

MASS-FIX may allow identification of patients at risk for light chain amyloidosis before the onset of symptoms

Kourelis, T., Murray, D. L., Dasari, S., Kumar, S., Barnidge, D., Madden, B., Arendt, B., Milani, P., Merlini, G., Ramirez-Alvarado, M., Kyle, R. A. & Dispenzieri, A., Jan 1 2018, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

5 Scopus citations

Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains

Misra, P., Blancas-Mejia, L. M. & Ramirez-Alvarado, M., Jun 25 2019, In : Biochemistry. 58, 29, p. 3155-3168 14 p.

Research output: Contribution to journalArticle

Mesenchymal stromal cells protect human cardiomyocytes from amyloid fibril damage

Lin, Y., Marin-Argany, M., Dick, C. J., Redhage, K. R., Blancas-Mejia, L. M., Bulur, P., Butler, G. W., Deeds, M. C., Madden, B. J., Williams, A., Wall, J. S., Dietz, A. B. & Ramirez-Alvarado, M., 2017, (Accepted/In press) In : Cytotherapy.

Research output: Contribution to journalArticle

5 Scopus citations

Monosialoganglioside-containing nanoliposomes restore endothelial function impaired by AL amyloidosis light chain proteins

Franco, D. A., Truran, S., Weissig, V., Guzman-Villanueva, D., Karamanova, N., Senapati, S., Burciu, C., Ramirez-Alvarado, M., Blancas-Mejia, L. M., Lindsay, S., Hari, P. & Migrino, R. Q., Jun 1 2016, In : Journal of the American Heart Association. 5, 6, e003318.

Research output: Contribution to journalArticle

3 Scopus citations

Motional dynamics of residues in a β-hairpin peptide measured by 13C- NMR relaxation

Ramirez-Alvarado, M., Daragan, V. A., Serrano, L. & Mayo, K. H., Mar 1998, In : Protein Science. 7, 3, p. 720-729 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils

Marin-Argany, M., Güell-Bosch, J., Blancas-Mejía, L. M., Villegas, S. & Ramirez-Alvarado, M., 2015, In : Protein Science. p. 1829-1840 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis

Poshusta, T. L., Sikkink, L. A., Leung, N., Clark, R. J., Dispenzieri, A. & Ramirez-Alvarado, M., Apr 13 2009, In : PloS one. 4, 4, e5169.

Research output: Contribution to journalArticle

48 Scopus citations

Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro

Ramírez-Alvarado, M., Cocco, M. J. & Regan, L., Mar 1 2003, In : Protein Science. 12, 3, p. 567-576 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Nanoliposomes protect against AL amyloid light chain protein-induced endothelial injury

Truran, S., Weissig, V., Ramirez-Alvarado, M., Franco, D. A., Burciu, C., Georges, J., Murarka, S., Okoth, W. A., Schwab, S., Hari, P. & Migrino, R. Q., Mar 1 2014, In : Journal of Liposome Research. 24, 1, p. 69-73 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Phenotyping polyclonal kappa and lambda light chain molecular mass distributions in patient serum using mass spectrometry

Barnidge, D. R., Dasari, S., Ramirez-Alvarado, M., Fontan, A., Willrich, M. A. V., Tschumper, R. C., Jelinek, D. F., Snyder, M. R., Dispenzieri, A., Katzmann, J. A. & Murray, D. L., Nov 7 2014, In : Journal of Proteome Research. 13, 11, p. 5198-5205 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Physiological and biophysical factors that influence Alzheimer's disease amyloid plaque targeting of native and putrescine modified human amyloid β40

Kandimalla, K. K., Curran, G. L., Holasek, S. S., Gilles, E. J., Wengenack, T. M., Ramirez-Alvarado, M. & Poduslo, J. F., Jun 27 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Preface

Ramirez-Alvarado, M., Kelly, J. W. & Dobson, C. M., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. xxv-xxvi

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

1 Scopus citations

Protein Misfolding Diseases: Current and Emerging Principles and Therapies

Ramirez-Alvarado, M., Kelly, J. W. & Dobson, C. M., Jul 2 2010, John Wiley and Sons.

Research output: Book/ReportBook

31 Scopus citations

Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity

Martin, E. B., Williams, A., Wooliver, C., Heidel, R. E., Adams, S., Dunlap, J., Ramirez-Alvarado, M., Blancas-Mejia, L., Kennel, S. J. & Wall, J. S., Mar 16 2017, In : Amyloid. 24, p. 24-25 2 p.

Research output: Contribution to journalLetter

Recruitment of Light Chains by Homologous and Heterologous Fibrils Shows Distinctive Kinetic and Conformational Specificity

Blancas-Mejía, L. M. & Ramirez-Alvarado, M., May 31 2016, In : Biochemistry. 55, 21, p. 2967-2978 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease

Lorenz, E. C., Sethi, S., Poshusta, T. L., Ramirez-Alvarado, M., Kumar, S., Lager, D. J., Fervenza, F. C. & Leung, N., Apr 1 2010, In : Nephrology Dialysis Transplantation. 25, 4, p. 1340-1343 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

RNA-p53 interactions in vitro

Riley, K. J. L., Ramirez-Alvarado, M. & Maher, L. J., Mar 6 2007, In : Biochemistry. 46, 9, p. 2480-2487 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes

Levinson, R. T., Olatoye, O. O., Randles, E. G., Howell, K. G., DiCostanzo, A. C. & Ramirez-Alvarado, M., Mar 1 2013, In : Scientific reports. 3, 1278.

Research output: Contribution to journalArticle

22 Scopus citations

Role of β-turn residues in β-hairpin formation and stability in designed peptides

Ramírez-Alvarado, M., Blanco, F. J., Niemann, H. & Serrano, L., Nov 7 1997, In : Journal of Molecular Biology. 273, 4, p. 898-912 15 p.

Research output: Contribution to journalArticle

122 Scopus citations

Salts enhance both protein stability and amyloid formation of an immunoglobulin light chain

Sikkink, L. A. & Ramirez-Alvarado, M., Jun 1 2008, In : Biophysical Chemistry. 135, 1-3, p. 25-31 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Selective contrast enhancement of individual Alzheimer's disease amyloid plaques using a polyamine and Gd-DOTA conjugated antibody fragment against fibrillar Aβ42 for magnetic resonance molecular imaging

Ramakrishnan, M., Wengenack, T. M., Kandimalla, K. K., Curran, G. L., Gilles, E. J., Ramirez-Alvarado, M., Lin, J., Garwood, M., Jack, C. R. & Poduslo, J. F., Aug 1 2008, In : Pharmaceutical research. 25, 8, p. 1861-1872 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Serum immunoglobulin free light-chain measurement in primary amyloidosis: Prognostic value and correlations with clinical features

Kumar, S., Dispenzieri, A., Katzmann, J. A., Larson, D. R., Colby, C. L., Lacy, M. Q., Hayman, S. R., Buadi, F. K., Leung, N., Zeldenrust, S. R., Ramirez-Alvarado, M., Clark, R. J., Kyle, R. A., Rajkumar, S. V. & Gertz, M. A., Dec 9 2010, In : Blood. 116, 24, p. 5126-5129 4 p.

Research output: Contribution to journalArticle

106 Scopus citations

Solid-state NMR chemical shift assignments for AL-09 VL immunoglobulin light chain fibrils

Piehl, D. W., Blancas-Mejía, L. M., Ramirez-Alvarado, M. & Rienstra, C. M., Oct 22 2016, (Accepted/In press) In : Biomolecular NMR Assignments. p. 1-6 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Structural Alterations within Native Amyloidogenic Immunoglobulin Light Chains

Randles, E. G., Thompson, J. R., Martin, D. J. & Ramirez-Alvarado, M., May 29 2009, In : Journal of Molecular Biology. 389, 1, p. 199-210 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Structural and functional studies of truncated hemolysin A from Proteus mirabilis

Weaver, T. M., Hocking, J. M., Bailey, L. J., Wawrzyn, G. T., Howard, D. R., Sikkink, L. A., Ramirez-Alvarado, M. & Thompson, J. R., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22297-22309 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Structural insights into the role of mutations in amyloidogenesis

Baden, E. M., Randles, E. G., Aboagye, A. K., Thompson, J. R. & Ramirez-Alvarado, M., Nov 7 2008, In : Journal of Biological Chemistry. 283, 45, p. 30950-30956 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Systemic amyloidoses

Blancas-Mejía, L. M. & Ramirez-Alvarado, M., Jun 1 2013, In : Annual Review of Biochemistry. 82, p. 745-774 30 p.

Research output: Contribution to journalReview article

107 Scopus citations

Systemic Amyloidoses

Ramirez-Alvarado, M. & Buxbaum, J. N., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 325-345 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The effects of sodium sulfate, glycosaminoglycans, and Congo red on the structure, stability, and amyloid formation of an immunoglobulin light-chain protein

Mclaughlin, R. W., De Stigter, J. K., Sikkink, L. A., Baden, E. M. & Ramirez-Alvarado, M., Jul 12 2006, In : Protein Science. 15, 7, p. 1710-1722 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

The Pneumocystis meiotic PCRan1p kinase exhibits unique temperature-regulated activity

Burgess, J. W., Kottom, T. J., Villegas, L. R., Lamont, J. D., Baden, E. M., Ramirez-Alvarado, M. & Limper, A. H., Dec 1 2009, In : American journal of respiratory cell and molecular biology. 41, 6, p. 714-721 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Thermal stability threshold for amyloid formation in light chain amyloidosis

Poshusta, T. L., Katoh, N., Gertz, M. A., Dispenzieri, A. & Ramirez-Alvarado, M., Nov 15 2013, In : International journal of molecular sciences. 14, 11, p. 22604-22617 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding

Blancas-Mejía, L. M., Horn, T. J., Marin-Argany, M., Auton, M., Tischer, A. & Ramirez-Alvarado, M., Aug 12 2015, In : Biophysical Chemistry. 207, p. 13-20 8 p., 5846.

Research output: Contribution to journalArticle

22 Scopus citations

ThT 101: a primer on the use of thioflavin T to investigate amyloid formation

Gade Malmos, K., Blancas-Mejia, L. M., Weber, B., Buchner, J., Ramirez-Alvarado, M., Naiki, H. & Otzen, D., Mar 27 2017, (Accepted/In press) In : Amyloid. p. 1-16 16 p.

Research output: Contribution to journalArticle

44 Scopus citations

Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface

DiCostanzo, A. C., Thompson, J. R., Peterson, F. C., Volkman, B. F. & Ramirez-Alvarado, M., Aug 10 2012, In : Journal of Biological Chemistry. 287, 33, p. 27997-28006 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface (The Journal of Biological Chemistry (2012) 287 (27997-28006))

DiCostanzo, A. C., Thompson, J. R., Peterson, F. C., Volkman, B. F. & Ramirez-Alvarado, M., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, 1 p.

Research output: Contribution to journalComment/debate

Open Access
42 Scopus citations

β-hairpin and β-sheet formation in designed linear peptides

Ramírez-Alvarado, M., Kortemme, T., Blanco, F. J. & Serrano, L., Jan 1 1999, In : Bioorganic and Medicinal Chemistry. 7, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

116 Scopus citations