• 3275 Citations
  • 30 Scopus h-Index
19962019
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Research Output 1996 2019

230 Citations (Scopus)

A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy

Khurana, R., Ionescu-Zanetti, C., Pope, M., Li, J., Nielson, L., Ramirez-Alvarado, M., Regan, L., Fink, A. L. & Carter, S. A., Aug 1 2003, In : Biophysical Journal. 85, 2, p. 1135-1144 10 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Amyloid
Synucleins
Immunoglobulin Light Chains
Proteins

Aggressive light chain amyloidosis cases have unstable immunoglobulin light chains

Sikkink, L. A., Baden, E. M., Vance, S. R., Riley, K. J. L., Moch, A. T. & Ramirez-Alvarado, M., Jan 1 2004, Amyloid and Amyloidosis. CRC Press, p. 55-57 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunoglobulin Light Chains
Amyloidosis
Light
76 Citations (Scopus)

Altered dimer interface decreases stability in an amyloidogenic protein

Baden, E. M., Owen, B. A. L., Peterson, F. C., Volkman, B. F., Ramirez-Alvarado, M. & Thompson, J. R., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 15853-15860 8 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Amyloidosis
Dimers
Light
Amyloid
16 Citations (Scopus)

Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils

Poduslo, J. F., Howell, K. G., Olson, N. C., Ramirez-Alvarado, M. & Kandimalla, K. K., May 15 2012, In : Biochemistry. 51, 19, p. 3993-4003 11 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Sequence Deletion
Alzheimer Disease
Rigidity
Neurons
31 Citations (Scopus)

Amyloid formation in light chain amyloidosis

Ramirez-Alvarado, M., 2012, In : Current Topics in Medicinal Chemistry. 12, 22, p. 2523-2533 11 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Light
Thermodynamics
Immunoglobulin Light Chains
17 Citations (Scopus)

Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL)

Abraham, R. S., Geyer, S. M., Ramirez-Alvarado, M., Price-Troska, T. L., Gertz, M. & Fonseca, R., Jul 2004, In : Journal of Clinical Immunology. 24, 4, p. 340-353 14 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloidosis
Amyloid
B-Lymphocytes
Proteostasis Deficiencies
2 Citations (Scopus)

A reappraisal of immunoglobulin variable gene primers and its impact on assessing clonal relationships between PB B cells and BM plasma cells in AL amyloidosis

Katoh, N., Poshusta, T. L., Manske, M. K., Dispenzieri, A., Gertz, M., Abraham, R. S. & Ramirez-Alvarado, M., Dec 2011, In : Journal of Clinical Immunology. 31, 6, p. 1029-1037 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Genes
Amyloidosis
Plasma Cells
Bone Marrow Cells
Blood Cells
29 Citations (Scopus)

A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface

Peterson, F. C., Baden, E. M., Owen, B. A. L., Volkman, B. F. & Ramirez-Alvarado, M., May 2010, In : Structure. 18, 5, p. 563-570 8 p.

Research output: Contribution to journalArticle

Light
Mutation
Amyloid
Proteostasis Deficiencies
Proteins

Assays for light chain amyloidosis formation and cytotoxicity

Blancas-Mejia, L. M., Misra, P., Dick, C. J., Marin-Argany, M., Redhage, K. R., Cooper, S. A. & Ramirez-Alvarado, M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 123-153 31 p. (Methods in Molecular Biology; vol. 1873).

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloidosis
Immunoglobulin Light Chains
Light
Fluorescence Spectrometry
Fluorescence Microscopy
4 Citations (Scopus)

Assay to rapidly screen for immunoglobulin light chain glycosylation: a potential path to earlier AL diagnosis for a subset of patients

Kumar, S., Murray, D., Dasari, S., Milani, P., Barnidge, D., Madden, B., Kourelis, T., Arendt, B., Merlini, G., Ramirez-Alvarado, M. & Dispenzieri, A., Jul 6 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Glycosylation
Early Diagnosis
5 Citations (Scopus)

Assessment of renal response with urinary exosomes in patients with AL amyloidosis: A proof of concept

Ramirez-Alvarado, M., Barnidge, D. R., Murray, D. L., Dispenzieri, A., Marin-Argany, M., Dick, C. J., Cooper, S. A., Nasr, S. H., Ward, C. J., Dasari, S., Jiménez-Zepeda, V. H. & Leung, N., Jun 1 2017, In : American Journal of Hematology. 92, 6, p. 536-541 6 p.

Research output: Contribution to journalArticle

Exosomes
Amyloidosis
Kidney
Amyloid
Immunoglobulin Light Chains
173 Citations (Scopus)
Protein Stability
Amyloid
Proteins
Amyloidogenic Proteins
Amyloidosis
28 Citations (Scopus)

A twisted four-sheeted model for an amyloid fibril

Wang, J., Gülich, S., Bradford, C., Ramirez-Alvarado, M. & Regan, L., Sep 2005, In : Structure. 13, 9, p. 1279-1288 10 p.

Research output: Contribution to journalArticle

Amyloid
Structural Models
Periodicity
X-Ray Diffraction
33 Citations (Scopus)

Biochemical and aggregation analysis of Bence Jones proteins from different light chain diseases

Sikkink, L. A. & Ramirez-Alvarado, M., 2008, In : Amyloid. 15, 1, p. 29-39 11 p.

Research output: Contribution to journalArticle

Bence Jones Protein
Light
Multiple Myeloma
Amyloidosis
Immunoglobulin Light Chains
44 Citations (Scopus)

Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2

Arendt, B. K., Ramirez-Alvarado, M., Sikkink, L. A., Keats, J. J., Ahmann, G. J., Dispenzieri, A., Fonseca, R., Ketterling, R. P., Knudson, R. A., Mulvihill, E. M., Tschumper, R. C., Wu, X., Zeldenrust, S. R. & Jelinek, D. F., Sep 1 2008, In : Blood. 112, 5, p. 1931-1941 11 p.

Research output: Contribution to journalArticle

Cells
Light
Cell Line
Amyloid
Amyloidosis
2 Citations (Scopus)

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease

Holditch, S. J., Schreiber, C. A., Harris, P. C., La Russo, N. F., Ramirez-Alvarado, M., Cataliotti, A., Torres, V. & Ikeda, Y. H., Jul 22 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Brain Natriuretic Peptide
Vasopressins
Disease Progression
Kidney
17 Citations (Scopus)

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
HIV
T-Lymphocytes
Caspase 8
Cell Death
54 Citations (Scopus)

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the co-chaperone p23

Chadli, A., Felts, S. J., Wang, Q., Sullivan, W. P., Botuyan, M. V., Fauq, A., Ramirez-Alvarado, M. & Mer, G., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 4224-4231 8 p.

Research output: Contribution to journalArticle

Steroid Receptors
Adenosine Triphosphate
Dissection
Molecules
Molecular Chaperones
18 Citations (Scopus)

Cell damage in light chain amyloidosis fibril internalization, toxicity and cell-mediated seeding

Marin-Argany, M., Lin, Y., Misra, P., Williams, A., Wall, J. S., Howell, K. G., Elsbernd, L. R., McClure, M. & Ramirez-Alvarado, M., Sep 16 2016, In : Journal of Biological Chemistry. 291, 38, p. 19813-19825 13 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Toxicity
Cells
Immunoglobulin Light Chains
3 Citations (Scopus)

Chapter 4 Principles of Protein Misfolding

Ramirez-Alvarado, M., 2008, In : Progress in Molecular Biology and Translational Science. 84, C, p. 115-160 46 p.

Research output: Contribution to journalArticle

Proteins
26 Citations (Scopus)

Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry

Kourelis, T., Dasari, S., Theis, J. D., Ramirez-Alvarado, M., Kurtin, P. J., Gertz, M., Zeldenrust, S. R., Zenka, R. M., Dogan, A. & Dispenzieri, A., Jan 19 2017, In : Blood. 129, 3, p. 299-306 8 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Immunoglobulin Genes
Amyloidosis
Mass spectrometry
Immunoglobulins
2 Citations (Scopus)

Clinical features, laboratory characteristics and outcomes of patients with renal versus cardiac light chain amyloidosis

Sidana, S., Tandon, N., Gertz, M., Dispenzieri, A., Ramirez-Alvarado, M., Murray, D. L., Kourelis, T., Buadi, F. K., Kapoor, P., Gonsalves, W., Warsame, R., Lacy, M., Kyle, R. A., Rajkumar, S. V., Kumar, S. K. & Leung, N., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

Amyloidosis
Kidney
Light
Plasma Cells
Bone Marrow Cells
20 Citations (Scopus)

Clonotypic light chain peptides identified for monitoring minimal residual disease in multiple myeloma without bone marrow aspiration

Bergen, H. R. B. III., Dasari, S., Dispenzieri, A., Mills, J. R., Ramirez-Alvarado, M., Tschumper, R. C., Jelinek, D. F., Barnidge, D. R. & Murray, D. L., Jan 1 2016, In : Clinical Chemistry. 62, 1, p. 243-251 9 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Multiple Myeloma
Bone
Bone Marrow
Light
20 Citations (Scopus)

Comparison of amyloid fibril formation by two closely related immunoglobulin light chain variable domains

Martin, D. J. & Ramirez-Alvarado, M., Sep 2010, In : Amyloid. 17, 3-4, p. 129-136 8 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloid
Amyloidosis
Phenotype
Light
78 Citations (Scopus)

Computer-aided design of β-sheet peptides

López, M., Lacroix, E., Ramirez-Alvarado, M. & Serrano, L., Sep 7 2001, In : Journal of Molecular Biology. 312, 1, p. 229-246 18 p.

Research output: Contribution to journalArticle

Computer-Aided Design
Peptides
Protein Engineering
Proteins
Circular Dichroism
42 Citations (Scopus)
Secondary Protein Structure
Peptides
Trifluoroethanol
Proteins
Nuclear magnetic resonance spectroscopy
17 Citations (Scopus)

Conformational exchange on the microsecond time scale in α-helix and β-hairpin peptides measured by 13C NMR transverse relaxation

Nesmelova, I., Krushelnitsky, A., Idiyatullin, D., Blanco, F., Ramirez-Alvarado, M., Daragan, V. A., Serrano, L. & Mayo, K. H., Mar 6 2001, In : Biochemistry. 40, 9, p. 2844-2853 10 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Peptides
Trifluoroethanol
Chemical shift
Water
Open Access
Immunoglobulin Light Chains
Glycosylation
Publications
Early Diagnosis
Leukemia
1 Citation (Scopus)

Correction to Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation [Journal of Cell Biology, 206, 7, (2014), 867-876]

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Wei Meng, X., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 207, 1, p. 159 1 p.

Research output: Contribution to journalArticle

HIV Protease
Cell Biology
T-Lymphocytes
30 Citations (Scopus)

Cytotoxicity of amyloidogenic immunoglobulin light chains in cell culture

Sikkink, L. A. & Ramirez-Alvarado, M., Nov 2010, In : Cell Death and Disease. 1, 11, e98.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloidosis
Poisons
Proteostasis Deficiencies
Cell Culture Techniques
270 Citations (Scopus)

De novo design and structural analysis of a model β-hairpin peptide system

Ramirez-Alvarado, M., Blanco, F. J. & Serrano, L., Jul 1996, In : Nature Structural Biology. 3, 7, p. 604-612 9 p.

Research output: Contribution to journalArticle

Structural analysis
Peptides
Alanine
Conformations
Linear Models
297 Citations (Scopus)

Design of a 20-amino acid, three-stranded β-sheet protein

Kortemme, T., Ramirez-Alvarado, M. & Serrano, L., Jul 10 1998, In : Science. 281, 5374, p. 253-256 4 p.

Research output: Contribution to journalArticle

Amino Acids
Proteins
Amyloid
2 Citations (Scopus)

Detection of ALECT2 amyloidosis by positron emission tomography–computed tomography imaging with florbetapir

Leung, N., Ramirez-Alvarado, M., Nasr, S. H., Kemp, B. J. & Johnson, G. B., Apr 1 2017, In : British Journal of Haematology. 177, 1, p. 12 1 p.

Research output: Contribution to journalComment/debate

Amyloidosis
Positron Emission Tomography Computed Tomography
florbetapir
26 Citations (Scopus)

Differences in immunoglobulin light chain species found in urinary exosomes in light chain amyloidosis (AL)

Ramirez-Alvarado, M., Ward, C. J., Huang, B. Q., Gong, X., Hogan, M. C., Madden, B. J., Charlesworth, M. C. & Leung, N., Jun 18 2012, In : PLoS One. 7, 6, e38061.

Research output: Contribution to journalArticle

immunoglobulin light chains
exosomes
Exosomes
Immunoglobulin Light Chains
amyloidosis
11 Citations (Scopus)

Differences in Protein Concentration Dependence for Nucleation and Elongation in Light Chain Amyloid Formation

Blancas-Mejía, L. M., Misra, P. & Ramirez-Alvarado, M., Feb 7 2017, In : Biochemistry. 56, 5, p. 757-766 10 p.

Research output: Contribution to journalArticle

Amyloid
Elongation
Nucleation
Light
Proteins
21 Citations (Scopus)

Differential effects on light chain amyloid formation depend on mutations and type of glycosaminoglycans

Blancas-Mejía, L. M., Hammernik, J., Marin-Argany, M. & Ramirez-Alvarado, M., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 4953-4965 13 p.

Research output: Contribution to journalArticle

Glycosaminoglycans
Amyloid
Light
Mutation
Proteins
3 Citations (Scopus)

Differential recruitment efficacy of patientderived amyloidogenic and myeloma light chain proteins by synthetic fibrilsA metric for predicting amyloid propensity

Martin, E. B., Williams, A., Wooliver, C., Heidel, R. E., Adams, S., Dunlap, J., Ramirez-Alvarado, M., Blancas-Mejia, L. M., Lands, R. H., Kennel, S. J. & Wall, J. S., Mar 1 2017, In : PLoS One. 12, 3, e0174152.

Research output: Contribution to journalArticle

myeloma
amyloid
Amyloid
Light
amyloidosis
22 Citations (Scopus)

Does the location of a mutation determine the ability to form amyloid fibrils?

Ramirez-Alvarado, M. & Regan, L., 2002, In : Journal of Molecular Biology. 323, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Amyloid
Mutation
Protein Stability
Freezing
Seeds
38 Citations (Scopus)

Domain: domain interactions within Hop, the Hsp70/Hsp90 organizing protein, are required for protein stability and structure

Carrigan, P. E., Sikkink, L. A., Smith, D. F. & Ramirez-Alvarado, M., Mar 2006, In : Protein Science. 15, 3, p. 522-532 11 p.

Research output: Contribution to journalArticle

Protein Stability
Heat-Shock Proteins
Protein Conformation
Point Mutation
Protein Binding
44 Citations (Scopus)

Elongation of the BH8 β-hairpin peptide: Electrostatic interactions in β-hairpin formation and stability

Ramirez-Alvarado, M., Blanco, F. J. & Serrano, L., 2001, In : Protein Science. 10, 7, p. 1381-1392 12 p.

Research output: Contribution to journalArticle

Coulomb interactions
Static Electricity
Elongation
Peptides
Salts
1 Citation (Scopus)

Erratum: Structural and functional studies of truncated hemolysin A from Proteus mirabilis (Journal of Biological Chemistry)

Weaver, T. M., Smith, J. A., Hocking, J. M., Bailey, L. J., Wawrzyn, G. T., Howard, D. R., Sikkink, L. A., Ramirez-Alvarado, M. & Thompson, J. R., Apr 5 2013, In : Journal of Biological Chemistry. 288, 14, p. 10092 1 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Evaluation of the BH3-only protein Puma as a direct Bak activator

Dai, H., Pang, Y-P., Ramirez-Alvarado, M. & Kaufmann, S. H., Jan 3 2014, In : Journal of Biological Chemistry. 289, 1, p. 89-99 11 p.

Research output: Contribution to journalArticle

Puma
Oligomerization
Noxae
Proteins
Membranes
134 Citations (Scopus)

Formation and stability of β-hairpin structures in polypeptides

Blanco, F., Ramirez-Alvarado, M. & Serrano, L., Feb 1998, In : Current Opinion in Structural Biology. 8, 1, p. 107-111 5 p.

Research output: Contribution to journalArticle

Peptides
Proteins
26 Citations (Scopus)
Amyloidosis
Amyloid
Disulfides
Light
Immunoglobulin Light Chains
16 Citations (Scopus)
Immunoglobulin Light Chains
Glycosaminoglycans
Amyloidogenic Proteins
Amyloid
Protein Precursors
78 Citations (Scopus)
thiopurine methyltransferase
Isoenzymes
Pharmacogenetics
Alleles
Proteins
3 Citations (Scopus)

Immunoglobulin light chain amyloid aggregation

Blancas-Mejia, L. M., Misra, P., Dick, C. J., Cooper, S. A., Redhage, K. R., Bergman, M. R., Jordan, T. L., Maar, K. & Ramirez-Alvarado, M., Jan 1 2018, In : Chemical Communications. 54, 76, p. 10664-10674 11 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloid
Agglomeration
Proteins
Cells
10 Citations (Scopus)

Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini

Piehl, D. W., Blancas-Mejía, L. M., Wall, J. S., Kennel, S. J., Ramirez-Alvarado, M. & Rienstra, C. M., Feb 28 2017, In : ACS Omega. 2, 2, p. 712-720 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Proteins
Rigidity
Nuclear magnetic resonance spectroscopy
Conformations
64 Citations (Scopus)

In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques

Poduslo, J. F., Ramakrishnan, M., Holasek, S. S., Ramirez-Alvarado, M., Kandimalla, K. K., Gilles, E. J., Curran, G. L. & Wengenack, T. M., Jul 2007, In : Journal of Neurochemistry. 102, 2, p. 420-433 14 p.

Research output: Contribution to journalArticle

Molecular imaging
Immunoglobulin Fragments
Molecular Imaging
Amyloid Plaques
Neurology
20 Citations (Scopus)
Amyloidosis
Multiple Myeloma
Plasmas
Light
Isoelectric Focusing