• 3406 Citations
  • 31 Scopus h-Index
19962020

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Article
2020

IgM AL amyloidosis: delineating disease biology and outcomes with clinical, genomic and bone marrow morphological features

Sidana, S., Larson, D. P., Greipp, P. T., He, R., McPhail, E. D., Dispenzieri, A., Murray, D. L., Dasari, S., Ansell, S. M., Muchtar, E., Gonsalves, W. I., Kourelis, T. V., Ramirez-Alvarado, M., Kapoor, P., Rajkumar, S. V., Lacy, M. Q., Buadi, F. K., Leung, N., Kyle, R. A., Kumar, S. K. & 2 others, King, R. L. & Gertz, M. A., May 1 2020, In : Leukemia. 34, 5, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Light chain amyloidosis induced inflammatory changes in cardiomyocytes and adipose-derived mesenchymal stromal cells

Jordan, T. L., Maar, K., Redhage, K. R., Misra, P., Blancas-Mejia, L. M., Dick, C. J., Wall, J. S., Williams, A., Dietz, A. B., van Wijnen, A. J., Lin, Y. & Ramirez-Alvarado, M., May 1 2020, In : Leukemia. 34, 5, p. 1383-1393 11 p.

Research output: Contribution to journalArticle

2019

Clinical features, laboratory characteristics and outcomes of patients with renal versus cardiac light chain amyloidosis

Sidana, S., Tandon, N., Gertz, M., Dispenzieri, A., Ramirez-Alvarado, M., Murray, D. L., Kourelis, T., Buadi, F. K., Kapoor, P., Gonsalves, W., Warsame, R., Lacy, M., Kyle, R. A., Rajkumar, S. V., Kumar, S. K. & Leung, N., Jan 1 2019, In : British journal of haematology.

Research output: Contribution to journalArticle

3 Scopus citations

Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains

Misra, P., Blancas-Mejia, L. M. & Ramirez-Alvarado, M., Jun 25 2019, In : Biochemistry. 58, 29, p. 3155-3168 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Assay to rapidly screen for immunoglobulin light chain glycosylation: a potential path to earlier AL diagnosis for a subset of patients

Kumar, S., Murray, D., Dasari, S., Milani, P., Barnidge, D., Madden, B., Kourelis, T., Arendt, B., Merlini, G., Ramirez-Alvarado, M. & Dispenzieri, A., Jul 6 2018, (Accepted/In press) In : Leukemia. p. 1-4 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Immunoglobulin light chain amyloid aggregation

Blancas-Mejia, L. M., Misra, P., Dick, C. J., Cooper, S. A., Redhage, K. R., Bergman, M. R., Jordan, T. L., Maar, K. & Ramirez-Alvarado, M., Jan 1 2018, In : Chemical Communications. 54, 76, p. 10664-10674 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

MASS-FIX may allow identification of patients at risk for light chain amyloidosis before the onset of symptoms

Kourelis, T., Murray, D. L., Dasari, S., Kumar, S., Barnidge, D., Madden, B., Arendt, B., Milani, P., Merlini, G., Ramirez-Alvarado, M., Kyle, R. A. & Dispenzieri, A., Jan 1 2018, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Assessment of renal response with urinary exosomes in patients with AL amyloidosis: A proof of concept

Ramirez-Alvarado, M., Barnidge, D. R., Murray, D. L., Dispenzieri, A., Marin-Argany, M., Dick, C. J., Cooper, S. A., Nasr, S. H., Ward, C. J., Dasari, S., Jiménez-Zepeda, V. H. & Leung, N., Jun 1 2017, In : American Journal of Hematology. 92, 6, p. 536-541 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry

Kourelis, T., Dasari, S., Theis, J. D., Ramirez-Alvarado, M., Kurtin, P. J., Gertz, M., Zeldenrust, S. R., Zenka, R. M., Dogan, A. & Dispenzieri, A., Jan 19 2017, In : Blood. 129, 3, p. 299-306 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Differences in Protein Concentration Dependence for Nucleation and Elongation in Light Chain Amyloid Formation

Blancas-Mejía, L. M., Misra, P. & Ramirez-Alvarado, M., Feb 7 2017, In : Biochemistry. 56, 5, p. 757-766 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Differential recruitment efficacy of patientderived amyloidogenic and myeloma light chain proteins by synthetic fibrilsA metric for predicting amyloid propensity

Martin, E. B., Williams, A., Wooliver, C., Heidel, R. E., Adams, S., Dunlap, J., Ramirez-Alvarado, M., Blancas-Mejia, L. M., Lands, R. H., Kennel, S. J. & Wall, J. S., Mar 1 2017, In : PLoS One. 12, 3, e0174152.

Research output: Contribution to journalArticle

3 Scopus citations

Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini

Piehl, D. W., Blancas-Mejía, L. M., Wall, J. S., Kennel, S. J., Ramirez-Alvarado, M. & Rienstra, C. M., Feb 28 2017, In : ACS Omega. 2, 2, p. 712-720 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients

Blancas-Mejía, L. M., Martin, E. B., Williams, A., Wall, J. S. & Ramirez-Alvarado, M., 2017, (Accepted/In press) In : Biophysical Chemistry.

Research output: Contribution to journalArticle

2 Scopus citations

Mesenchymal stromal cells protect human cardiomyocytes from amyloid fibril damage

Lin, Y., Marin-Argany, M., Dick, C. J., Redhage, K. R., Blancas-Mejia, L. M., Bulur, P., Butler, G. W., Deeds, M. C., Madden, B. J., Williams, A., Wall, J. S., Dietz, A. B. & Ramirez-Alvarado, M., 2017, (Accepted/In press) In : Cytotherapy.

Research output: Contribution to journalArticle

5 Scopus citations

ThT 101: a primer on the use of thioflavin T to investigate amyloid formation

Gade Malmos, K., Blancas-Mejia, L. M., Weber, B., Buchner, J., Ramirez-Alvarado, M., Naiki, H. & Otzen, D., Mar 27 2017, (Accepted/In press) In : Amyloid. p. 1-16 16 p.

Research output: Contribution to journalArticle

44 Scopus citations
2016

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease

Holditch, S. J., Schreiber, C. A., Harris, P. C., La Russo, N. F., Ramirez-Alvarado, M., Cataliotti, A., Torres, V. & Ikeda, Y. H., Jul 22 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

4 Scopus citations

Cell damage in light chain amyloidosis fibril internalization, toxicity and cell-mediated seeding

Marin-Argany, M., Lin, Y., Misra, P., Williams, A., Wall, J. S., Howell, K. G., Elsbernd, L. R., McClure, M. & Ramirez-Alvarado, M., Sep 16 2016, In : Journal of Biological Chemistry. 291, 38, p. 19813-19825 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Clonotypic light chain peptides identified for monitoring minimal residual disease in multiple myeloma without bone marrow aspiration

Bergen, H. R. B. III., Dasari, S., Dispenzieri, A., Mills, J. R., Ramirez-Alvarado, M., Tschumper, R. C., Jelinek, D. F., Barnidge, D. R. & Murray, D. L., Jan 1 2016, In : Clinical Chemistry. 62, 1, p. 243-251 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Monosialoganglioside-containing nanoliposomes restore endothelial function impaired by AL amyloidosis light chain proteins

Franco, D. A., Truran, S., Weissig, V., Guzman-Villanueva, D., Karamanova, N., Senapati, S., Burciu, C., Ramirez-Alvarado, M., Blancas-Mejia, L. M., Lindsay, S., Hari, P. & Migrino, R. Q., Jun 1 2016, In : Journal of the American Heart Association. 5, 6, e003318.

Research output: Contribution to journalArticle

3 Scopus citations

Recruitment of Light Chains by Homologous and Heterologous Fibrils Shows Distinctive Kinetic and Conformational Specificity

Blancas-Mejía, L. M. & Ramirez-Alvarado, M., May 31 2016, In : Biochemistry. 55, 21, p. 2967-2978 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Solid-state NMR chemical shift assignments for AL-09 VL immunoglobulin light chain fibrils

Piehl, D. W., Blancas-Mejía, L. M., Ramirez-Alvarado, M. & Rienstra, C. M., Oct 22 2016, (Accepted/In press) In : Biomolecular NMR Assignments. p. 1-6 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Differential effects on light chain amyloid formation depend on mutations and type of glycosaminoglycans

Blancas-Mejía, L. M., Hammernik, J., Marin-Argany, M. & Ramirez-Alvarado, M., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 4953-4965 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Light chain amyloid fibrils cause metabolic dysfunction in human cardiomyocytes

McWilliams-Koeppen, H. P., Foster, J. S., Hackenbrack, N., Ramirez-Alvarado, M., Donohoe, D., Williams, A., Macy, S., Wooliver, C., Wortham, D., Morrell-Falvey, J., Foster, C. M., Kennel, S. J. & Wall, J. S., Sep 22 2015, In : PLoS One. 10, 9, e0137716.

Research output: Contribution to journalArticle

34 Scopus citations

Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils

Marin-Argany, M., Güell-Bosch, J., Blancas-Mejía, L. M., Villegas, S. & Ramirez-Alvarado, M., 2015, In : Protein Science. p. 1829-1840 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding

Blancas-Mejía, L. M., Horn, T. J., Marin-Argany, M., Auton, M., Tischer, A. & Ramirez-Alvarado, M., Aug 12 2015, In : Biophysical Chemistry. 207, p. 13-20 8 p., 5846.

Research output: Contribution to journalArticle

22 Scopus citations
2014

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y. P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., Jan 1 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Evaluation of the BH3-only protein Puma as a direct Bak activator

Dai, H., Pang, Y. P., Ramirez-Alvarado, M. & Kaufmann, S. H., Jan 3 2014, In : Journal of Biological Chemistry. 289, 1, p. 89-99 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations

Blancas-Mejía, L. M., Tischer, A., Thompson, J. R., Tai, J., Wang, L., Auton, M. & Ramirez-Alvarado, M., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 347-361 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Nanoliposomes protect against AL amyloid light chain protein-induced endothelial injury

Truran, S., Weissig, V., Ramirez-Alvarado, M., Franco, D. A., Burciu, C., Georges, J., Murarka, S., Okoth, W. A., Schwab, S., Hari, P. & Migrino, R. Q., Mar 1 2014, In : Journal of Liposome Research. 24, 1, p. 69-73 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Phenotyping polyclonal kappa and lambda light chain molecular mass distributions in patient serum using mass spectrometry

Barnidge, D. R., Dasari, S., Ramirez-Alvarado, M., Fontan, A., Willrich, M. A. V., Tschumper, R. C., Jelinek, D. F., Snyder, M. R., Dispenzieri, A., Katzmann, J. A. & Murray, D. L., Nov 7 2014, In : Journal of Proteome Research. 13, 11, p. 5198-5205 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes

Levinson, R. T., Olatoye, O. O., Randles, E. G., Howell, K. G., DiCostanzo, A. C. & Ramirez-Alvarado, M., Mar 1 2013, In : Scientific reports. 3, 1278.

Research output: Contribution to journalArticle

23 Scopus citations

Thermal stability threshold for amyloid formation in light chain amyloidosis

Poshusta, T. L., Katoh, N., Gertz, M. A., Dispenzieri, A. & Ramirez-Alvarado, M., Nov 15 2013, In : International journal of molecular sciences. 14, 11, p. 22604-22617 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
2012

Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils

Poduslo, J. F., Howell, K. G., Olson, N. C., Ramirez-Alvarado, M. & Kandimalla, K. K., May 15 2012, In : Biochemistry. 51, 19, p. 3993-4003 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Amyloid formation in light chain amyloidosis

Ramirez-Alvarado, M., Dec 1 2012, In : Current Topics in Medicinal Chemistry. 12, 22, p. 2523-2533 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Differences in immunoglobulin light chain species found in urinary exosomes in light chain amyloidosis (AL)

Ramirez-Alvarado, M., Ward, C. J., Huang, B. Q., Gong, X., Hogan, M. C., Madden, B. J., Charlesworth, M. C. & Leung, N., Jun 18 2012, In : PloS one. 7, 6, e38061.

Research output: Contribution to journalArticle

26 Scopus citations

Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface

DiCostanzo, A. C., Thompson, J. R., Peterson, F. C., Volkman, B. F. & Ramirez-Alvarado, M., Aug 10 2012, In : Journal of Biological Chemistry. 287, 33, p. 27997-28006 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
Open Access
42 Scopus citations
2011

A reappraisal of immunoglobulin variable gene primers and its impact on assessing clonal relationships between PB B cells and BM plasma cells in AL amyloidosis

Katoh, N., Poshusta, T. L., Manske, M. K., Dispenzieri, A., Gertz, M. A., Abraham, R. S. & Ramirez-Alvarado, M., Dec 1 2011, In : Journal of Clinical Immunology. 31, 6, p. 1029-1037 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Glycosaminoglycans promote fibril formation by amyloidogenic immunoglobulin light chains through a transient interaction

Martin, D. J. & Ramirez-Alvarado, M., Sep 1 2011, In : Biophysical Chemistry. 158, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2010

A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface

Peterson, F. C., Baden, E. M., Owen, B. A. L., Volkman, B. F. & Ramirez-Alvarado, M., May 1 2010, In : Structure. 18, 5, p. 563-570 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the co-chaperone p23

Chadli, A., Felts, S. J., Wang, Q., Sullivan, W. P., Botuyan, M. V., Fauq, A., Ramirez-Alvarado, M. & Mer, G., Feb 5 2010, In : Journal of Biological Chemistry. 285, 6, p. 4224-4231 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Comparison of amyloid fibril formation by two closely related immunoglobulin light chain variable domains

Martin, D. J. & Ramirez-Alvarado, M., Sep 1 2010, In : Amyloid. 17, 3-4, p. 129-136 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cytotoxicity of amyloidogenic immunoglobulin light chains in cell culture

Sikkink, L. A. & Ramirez-Alvarado, M., Nov 1 2010, In : Cell Death and Disease. 1, 11, e98.

Research output: Contribution to journalArticle

35 Scopus citations

Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease

Lorenz, E. C., Sethi, S., Poshusta, T. L., Ramirez-Alvarado, M., Kumar, S., Lager, D. J., Fervenza, F. C. & Leung, N., Apr 1 2010, In : Nephrology Dialysis Transplantation. 25, 4, p. 1340-1343 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Serum immunoglobulin free light-chain measurement in primary amyloidosis: Prognostic value and correlations with clinical features

Kumar, S., Dispenzieri, A., Katzmann, J. A., Larson, D. R., Colby, C. L., Lacy, M. Q., Hayman, S. R., Buadi, F. K., Leung, N., Zeldenrust, S. R., Ramirez-Alvarado, M., Clark, R. J., Kyle, R. A., Rajkumar, S. V. & Gertz, M. A., Dec 9 2010, In : Blood. 116, 24, p. 5126-5129 4 p.

Research output: Contribution to journalArticle

106 Scopus citations
2009
26 Scopus citations

Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis

Poshusta, T. L., Sikkink, L. A., Leung, N., Clark, R. J., Dispenzieri, A. & Ramirez-Alvarado, M., Apr 13 2009, In : PloS one. 4, 4, e5169.

Research output: Contribution to journalArticle

48 Scopus citations

Structural Alterations within Native Amyloidogenic Immunoglobulin Light Chains

Randles, E. G., Thompson, J. R., Martin, D. J. & Ramirez-Alvarado, M., May 29 2009, In : Journal of Molecular Biology. 389, 1, p. 199-210 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Structural and functional studies of truncated hemolysin A from Proteus mirabilis

Weaver, T. M., Hocking, J. M., Bailey, L. J., Wawrzyn, G. T., Howard, D. R., Sikkink, L. A., Ramirez-Alvarado, M. & Thompson, J. R., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22297-22309 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

The Pneumocystis meiotic PCRan1p kinase exhibits unique temperature-regulated activity

Burgess, J. W., Kottom, T. J., Villegas, L. R., Lamont, J. D., Baden, E. M., Ramirez-Alvarado, M. & Limper, A. H., Dec 1 2009, In : American journal of respiratory cell and molecular biology. 41, 6, p. 714-721 8 p.

Research output: Contribution to journalArticle

5 Scopus citations