• 3325 Citations
  • 31 Scopus h-Index
19962019
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Research Output 1996 2019

2010
31 Citations (Scopus)

Protein Misfolding Diseases: Current and Emerging Principles and Therapies

Ramirez-Alvarado, M., Kelly, J. W. & Dobson, C. M., Jul 2 2010, John Wiley and Sons.

Research output: Book/ReportBook

Proteostasis Deficiencies
Amyloid
Proteins
Therapeutics
Research Personnel
24 Citations (Scopus)

Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease

Lorenz, E. C., Sethi, S. M., Poshusta, T. L., Ramirez-Alvarado, M., Kumar, S. K., Lager, D. J., Fervenza, F. C. & Leung, N., Apr 2010, In : Nephrology Dialysis Transplantation. 25, 4, p. 1340-1343 4 p.

Research output: Contribution to journalArticle

Amyloidosis
Renal Insufficiency
Multiple Myeloma
Kidney
Light
104 Citations (Scopus)

Serum immunoglobulin free light-chain measurement in primary amyloidosis: Prognostic value and correlations with clinical features

Kumar, S. K., Dispenzieri, A., Katzmann, J. A., Larson, D. R., Colby, C. L., Lacy, M., Hayman, S. R., Buadi, F. K., Leung, N., Zeldenrust, S. R., Ramirez-Alvarado, M., Clark, R. J., Kyle, R. A., Rajkumar, S. V. & Gertz, M., Dec 9 2010, In : Blood. 116, 24, p. 5126-5129 4 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloidosis
Immunoglobulins
Light
Serum

Systemic Amyloidoses

Ramirez-Alvarado, M. & Buxbaum, J. N., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 325-345 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloidosis
2009
26 Citations (Scopus)
Amyloidosis
Amyloid
Disulfides
Light
Immunoglobulin Light Chains
33 Citations (Scopus)

Light chain amyloidosis - Current findings and future prospects

Baden, E. M., Sikkink, L. A. & Ramirez-Alvarado, M., 2009, In : Current Protein and Peptide Science. 10, 5, p. 500-508 9 p.

Research output: Contribution to journalArticle

Amyloidosis
Light
Amyloid
Amyloidogenic Proteins
Proteins
47 Citations (Scopus)

Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis

Poshusta, T. L., Sikkink, L. A., Leung, N., Clark, R. J., Dispenzieri, A. & Ramirez-Alvarado, M., Apr 13 2009, In : PLoS One. 4, 4, e5169.

Research output: Contribution to journalArticle

immunoglobulin light chains
Immunoglobulin Light Chains
amyloidosis
Amyloidosis
amyloid
29 Citations (Scopus)

Structural Alterations within Native Amyloidogenic Immunoglobulin Light Chains

Randles, E. G., Thompson, J. R., Martin, D. J. & Ramirez-Alvarado, M., May 29 2009, In : Journal of Molecular Biology. 389, 1, p. 199-210 12 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloidosis
Amyloid
Proteins
Protein Precursors
25 Citations (Scopus)

Structural and functional studies of truncated hemolysin A from Proteus mirabilis

Weaver, T. M., Hocking, J. M., Bailey, L. J., Wawrzyn, G. T., Howard, D. R., Sikkink, L. A., Ramirez-Alvarado, M. & Thompson, J. R., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22297-22309 13 p.

Research output: Contribution to journalArticle

Proteus mirabilis
Hemolysin Proteins
Secretory Pathway
Hemolysis
Molecules
5 Citations (Scopus)

The Pneumocystis meiotic PCRan1p kinase exhibits unique temperature-regulated activity

Burgess, J. W., Kottom, T. J., Villegas, L. R., Lamont, J. D., Baden, E. M., Ramirez-Alvarado, M. & Limper, A. H., Dec 1 2009, In : American Journal of Respiratory Cell and Molecular Biology. 41, 6, p. 714-721 8 p.

Research output: Contribution to journalArticle

Pneumocystis
Phosphotransferases
Life Cycle Stages
Life cycle
Temperature
2008
76 Citations (Scopus)

Altered dimer interface decreases stability in an amyloidogenic protein

Baden, E. M., Owen, B. A. L., Peterson, F. C., Volkman, B. F., Ramirez-Alvarado, M. & Thompson, J. R., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 15853-15860 8 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Amyloidosis
Dimers
Light
Amyloid
33 Citations (Scopus)

Biochemical and aggregation analysis of Bence Jones proteins from different light chain diseases

Sikkink, L. A. & Ramirez-Alvarado, M., 2008, In : Amyloid. 15, 1, p. 29-39 11 p.

Research output: Contribution to journalArticle

Bence Jones Protein
Light
Multiple Myeloma
Amyloidosis
Immunoglobulin Light Chains
44 Citations (Scopus)

Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2

Arendt, B. K., Ramirez-Alvarado, M., Sikkink, L. A., Keats, J. J., Ahmann, G. J., Dispenzieri, A., Fonseca, R., Ketterling, R. P., Knudson, R. A., Mulvihill, E. M., Tschumper, R. C., Wu, X., Zeldenrust, S. R. & Jelinek, D. F., Sep 1 2008, In : Blood. 112, 5, p. 1931-1941 11 p.

Research output: Contribution to journalArticle

Cells
Light
Cell Line
Amyloid
Amyloidosis
3 Citations (Scopus)

Chapter 4 Principles of Protein Misfolding

Ramirez-Alvarado, M., 2008, In : Progress in Molecular Biology and Translational Science. 84, C, p. 115-160 46 p.

Research output: Contribution to journalArticle

Proteins
20 Citations (Scopus)
Amyloidosis
Multiple Myeloma
Plasmas
Light
Isoelectric Focusing
37 Citations (Scopus)

Salts enhance both protein stability and amyloid formation of an immunoglobulin light chain

Sikkink, L. A. & Ramirez-Alvarado, M., Jun 2008, In : Biophysical Chemistry. 135, 1-3, p. 25-31 7 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Protein Stability
Amyloid
Salts
A73025
38 Citations (Scopus)

Selective contrast enhancement of individual Alzheimer's disease amyloid plaques using a polyamine and Gd-DOTA conjugated antibody fragment against fibrillar Aβ42 for magnetic resonance molecular imaging

Ramakrishnan, M., Wengenack, T. M., Kandimalla, K. K., Curran, G. L., Gilles, E. J., Ramirez-Alvarado, M., Lin, J., Garwood, M., Jack, C. R. J. & Poduslo, J. F., Aug 2008, In : Pharmaceutical Research. 25, 8, p. 1861-1872 12 p.

Research output: Contribution to journalArticle

Molecular imaging
Immunoglobulin Fragments
Molecular Imaging
Amyloid Plaques
Polyamines
44 Citations (Scopus)

Structural insights into the role of mutations in amyloidogenesis

Baden, E. M., Randles, E. G., Aboagye, A. K., Thompson, J. R. & Ramirez-Alvarado, M., Nov 7 2008, In : Journal of Biological Chemistry. 283, 45, p. 30950-30956 7 p.

Research output: Contribution to journalArticle

Dimers
Mutation
Proteins
Immunoglobulin Light Chains
Germ-Line Mutation
2007
64 Citations (Scopus)

In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques

Poduslo, J. F., Ramakrishnan, M., Holasek, S. S., Ramirez-Alvarado, M., Kandimalla, K. K., Gilles, E. J., Curran, G. L. & Wengenack, T. M., Jul 2007, In : Journal of Neurochemistry. 102, 2, p. 420-433 14 p.

Research output: Contribution to journalArticle

Molecular imaging
Immunoglobulin Fragments
Molecular Imaging
Amyloid Plaques
Neurology
12 Citations (Scopus)

RNA-p53 interactions in vitro

Riley, K. J. L., Ramirez-Alvarado, M. & Maher III, L. J., Mar 6 2007, In : Biochemistry. 46, 9, p. 2480-2487 8 p.

Research output: Contribution to journalArticle

RNA
Peptides
In Vitro Techniques
Tumor Suppressor Protein p53
Circular dichroism spectroscopy
2006
38 Citations (Scopus)

Domain: domain interactions within Hop, the Hsp70/Hsp90 organizing protein, are required for protein stability and structure

Carrigan, P. E., Sikkink, L. A., Smith, D. F. & Ramirez-Alvarado, M., Mar 2006, In : Protein Science. 15, 3, p. 522-532 11 p.

Research output: Contribution to journalArticle

Protein Stability
Heat-Shock Proteins
Protein Conformation
Point Mutation
Protein Binding
9 Citations (Scopus)

Physiological and biophysical factors that influence Alzheimer's disease amyloid plaque targeting of native and putrescine modified human amyloid β40

Kandimalla, K. K., Curran, G. L., Holasek, S. S., Gilles, E. J., Wengenack, T. M., Ramirez-Alvarado, M. & Poduslo, J. F., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Putrescine
Amyloid Plaques
Amyloid
Alzheimer Disease
Brain
60 Citations (Scopus)

The effects of sodium sulfate, glycosaminoglycans, and Congo red on the structure, stability, and amyloid formation of an immunoglobulin light-chain protein

Mclaughlin, R. W., De Stigter, J. K., Sikkink, L. A., Baden, E. M. & Ramirez-Alvarado, M., 2006, In : Protein Science. 15, 7, p. 1710-1722 13 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Congo Red
Amyloidosis
Glycosaminoglycans
Amyloid
2005
28 Citations (Scopus)

A twisted four-sheeted model for an amyloid fibril

Wang, J., Gülich, S., Bradford, C., Ramirez-Alvarado, M. & Regan, L., Sep 2005, In : Structure. 13, 9, p. 1279-1288 10 p.

Research output: Contribution to journalArticle

Amyloid
Structural Models
Periodicity
X-Ray Diffraction
78 Citations (Scopus)
thiopurine methyltransferase
Isoenzymes
Pharmacogenetics
Alleles
Proteins
2004

Aggressive light chain amyloidosis cases have unstable immunoglobulin light chains

Sikkink, L. A., Baden, E. M., Vance, S. R., Riley, K. J. L., Moch, A. T. & Ramirez-Alvarado, M., Jan 1 2004, Amyloid and Amyloidosis. CRC Press, p. 55-57 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunoglobulin Light Chains
Amyloidosis
Light
17 Citations (Scopus)

Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL)

Abraham, R. S., Geyer, S. M., Ramirez-Alvarado, M., Price-Troska, T. L., Gertz, M. & Fonseca, R., Jul 2004, In : Journal of Clinical Immunology. 24, 4, p. 340-353 14 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloidosis
Amyloid
B-Lymphocytes
Proteostasis Deficiencies
2003
231 Citations (Scopus)

A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy

Khurana, R., Ionescu-Zanetti, C., Pope, M., Li, J., Nielson, L., Ramirez-Alvarado, M., Regan, L., Fink, A. L. & Carter, S. A., Aug 1 2003, In : Biophysical Journal. 85, 2, p. 1135-1144 10 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Amyloid
Synucleins
Immunoglobulin Light Chains
Proteins
14 Citations (Scopus)

Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro

Ramirez-Alvarado, M., Cocco, M. J. & Regan, L., Mar 1 2003, In : Protein Science. 12, 3, p. 567-576 10 p.

Research output: Contribution to journalArticle

Amyloid
Mutation
Kinetics
Proteins
Light scattering
2002
22 Citations (Scopus)

Does the location of a mutation determine the ability to form amyloid fibrils?

Ramirez-Alvarado, M. & Regan, L., 2002, In : Journal of Molecular Biology. 323, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Amyloid
Mutation
Protein Stability
Freezing
Seeds
2001
78 Citations (Scopus)

Computer-aided design of β-sheet peptides

López, M., Lacroix, E., Ramirez-Alvarado, M. & Serrano, L., Sep 7 2001, In : Journal of Molecular Biology. 312, 1, p. 229-246 18 p.

Research output: Contribution to journalArticle

Computer-Aided Design
Peptides
Protein Engineering
Proteins
Circular Dichroism
17 Citations (Scopus)

Conformational exchange on the microsecond time scale in α-helix and β-hairpin peptides measured by 13C NMR transverse relaxation

Nesmelova, I., Krushelnitsky, A., Idiyatullin, D., Blanco, F., Ramirez-Alvarado, M., Daragan, V. A., Serrano, L. & Mayo, K. H., Mar 6 2001, In : Biochemistry. 40, 9, p. 2844-2853 10 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Peptides
Trifluoroethanol
Chemical shift
Water
44 Citations (Scopus)

Elongation of the BH8 β-hairpin peptide: Electrostatic interactions in β-hairpin formation and stability

Ramirez-Alvarado, M., Blanco, F. J. & Serrano, L., 2001, In : Protein Science. 10, 7, p. 1381-1392 12 p.

Research output: Contribution to journalArticle

Coulomb interactions
Static Electricity
Elongation
Peptides
Salts
2000
176 Citations (Scopus)
Protein Stability
Amyloid
Proteins
Amyloidogenic Proteins
Amyloidosis
1999
116 Citations (Scopus)

β-hairpin and β-sheet formation in designed linear peptides

Ramirez-Alvarado, M., Kortemme, T., Blanco, F. J. & Serrano, L., Jan 1999, In : Bioorganic and Medicinal Chemistry. 7, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

Peptides
Structural Models
Mutant Proteins
Hydrophobic and Hydrophilic Interactions
Structural analysis
1998
297 Citations (Scopus)

Design of a 20-amino acid, three-stranded β-sheet protein

Kortemme, T., Ramirez-Alvarado, M. & Serrano, L., Jul 10 1998, In : Science. 281, 5374, p. 253-256 4 p.

Research output: Contribution to journalArticle

Amino Acids
Proteins
Amyloid
134 Citations (Scopus)

Formation and stability of β-hairpin structures in polypeptides

Blanco, F., Ramirez-Alvarado, M. & Serrano, L., Feb 1998, In : Current Opinion in Structural Biology. 8, 1, p. 107-111 5 p.

Research output: Contribution to journalArticle

Peptides
Proteins
21 Citations (Scopus)

Motional dynamics of residues in a β-hairpin peptide measured by 13C- NMR relaxation

Ramirez-Alvarado, M., Daragan, V. A., Serrano, L. & Mayo, K. H., Mar 1998, In : Protein Science. 7, 3, p. 720-729 10 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Peptides
Protein folding
Protein Unfolding
Carbon-13 Magnetic Resonance Spectroscopy
1997
42 Citations (Scopus)
Secondary Protein Structure
Peptides
Trifluoroethanol
Proteins
Nuclear magnetic resonance spectroscopy
122 Citations (Scopus)

Role of β-turn residues in β-hairpin formation and stability in designed peptides

Ramirez-Alvarado, M., Blanco, F. J., Niemann, H. & Serrano, L., Nov 7 1997, In : Journal of Molecular Biology. 273, 4, p. 898-912 15 p.

Research output: Contribution to journalArticle

Peptides
Protein Databases
Population
Mutation
1996
270 Citations (Scopus)

De novo design and structural analysis of a model β-hairpin peptide system

Ramirez-Alvarado, M., Blanco, F. J. & Serrano, L., Jul 1996, In : Nature Structural Biology. 3, 7, p. 604-612 9 p.

Research output: Contribution to journalArticle

Structural analysis
Peptides
Alanine
Conformations
Linear Models